Tuberculosis

Also known as: Tuberculosis NOS / Infection TBC / Infection tuberculosis / TB / Tuberculous infections / Tuberculosis (A15-A19)

DrugDrug NameDrug Description
DB00479AmikacinAmikacin is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A. Similar to other aminoglycosides, amikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and tRNA acceptor sites leading to the production of non-functional or toxic peptides. Other mechanisms not fully understood may confer the bactericidal effects of amikacin. Amikacin is also nephrotoxic and ototoxic.
DB00233Aminosalicylic AcidAn antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid.
DB10343Bacillus calmette-guerin substrain tice live antigenBacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis.
DB00314CapreomycinCyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. [PubChem]
DB01380Cortisone acetateCortisone acetate is a steroid hormone that has both glucocoriticoid and mineral corticoid activities. Corticosteroids are used to provide relief for inflamed areas of the body. They lessen swelling, redness, itching, and allergic reactions. They are often used as part of the treatment for a number of different diseases, such as severe allergies or skin problems, asthma, or arthritis. Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called CBG, corticosteroid-binding protein), whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor.
DB01234DexamethasoneAn anti-inflammatory 9-fluoro-glucocorticoid. [PubChem]
DB01137LevofloxacinA synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. [PubChem]
DB00959MethylprednisoloneA prednisolone derivative with similar anti-inflammatory action. [PubChem]
DB00860PrednisoloneA glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. [PubChem]
DB00615RifabutinA broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. [PubChem]
DB01082StreptomycinStreptomycin is an aminoglycoside antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by binding to the 30S ribosomal subunit of susceptible organisms and disrupting the initiation and elongation steps in protein synthesis. It is bactericidal due to effects that are not fully understood.
DrugDrug NameTargetType
DB00479Amikacin30S ribosomal protein S12target
DB00479Amikacin16S rRNAtarget
DB00233Aminosalicylic Acid2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasetarget
DB00233Aminosalicylic AcidGroup IIE secretory phospholipase A2target
DB00233Aminosalicylic AcidProstaglandin G/H synthase 2target
DB00233Aminosalicylic AcidArachidonate 5-lipoxygenasetarget
DB00233Aminosalicylic AcidInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00233Aminosalicylic AcidMyeloperoxidaseenzyme
DB00314Capreomycin70S ribosometarget
DB01380Cortisone acetateGlucocorticoid receptortarget
DB01380Cortisone acetateCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneCytochrome P450 2C9enzyme
DB01234DexamethasoneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 19A1enzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 1B1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2D6enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneMultidrug resistance protein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinMultidrug resistance protein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB00959MethylprednisoloneGlucocorticoid receptortarget
DB00959MethylprednisoloneCytochrome P450 3A4enzyme
DB00959MethylprednisoloneMultidrug resistance protein 1transporter
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneMultidrug resistance protein 1transporter
DB00860PrednisoloneCytochrome P450 2A6enzyme
DB00615RifabutinDNA-directed RNA polymerase subunit alphatarget
DB00615RifabutinHeat shock protein HSP 90-alphatarget
DB00615RifabutinEndoplasmintarget
DB00615RifabutinCytochrome P450 3A4enzyme
DB00615RifabutinDNA-directed RNA polymerase subunit betatarget
DB00615RifabutinDNA-directed RNA polymerase subunit beta'target
DB00615RifabutinCytochrome P450 1A2enzyme
DB01082Streptomycin30S ribosomal protein S12target
DB01082Streptomycin16S rRNAtarget
DB01082StreptomycinSolute carrier family 22 member 6transporter
DB01082StreptomycinProtein-arginine deiminase type-4target
DrugDrug NamePhaseStatusCount
DB12768BCG vaccine0Completed1
DB12768BCG vaccine0Recruiting1
DB08903Bedaquiline0Completed1
DB00437Allopurinol1Completed1
DB01060Amoxicillin1Completed1
DB12768BCG vaccine1Completed7
DB12768BCG vaccine1Recruiting1
DB12386Bacillus calmette-guerin substrain danish 1331 live antigen1Completed1
DB08903Bedaquiline1Completed4
DB01156Bupropion1Recruiting1
DB00482Celecoxib1Completed1
DB00766Clavulanate1Completed1
DB08930Dolutegravir1Not Yet Recruiting1
DB00625Efavirenz1Completed4
DB00879Emtricitabine1Completed1
DB00330Ethambutol1Completed1
DB00330Ethambutol1Recruiting1
DB01628Etoricoxib1Recruiting1
DB12190Faropenem1Completed1
DB00117Histidine1Recruiting1
DB00951Isoniazid1Completed6
DB00951Isoniazid1Recruiting1
DB01172Kanamycin1Completed1
DB00125L-Arginine1Recruiting1
DB00709Lamivudine1Completed1
DB01137Levofloxacin1Completed1
DB00601Linezolid1Completed1
DB01601Lopinavir1Completed1
DB01601Lopinavir1Terminated1
DB00683Midazolam1Completed2
DB00683Midazolam1Recruiting1
DB00218Moxifloxacin1Completed2
DB00218Moxifloxacin1Withdrawn1
DB00220Nelfinavir1Completed1
DB00339Pyrazinamide1Completed4
DB00339Pyrazinamide1Recruiting1
DB00165Pyridoxine1Completed1
DB06817Raltegravir1Completed1
DB00615Rifabutin1Completed2
DB00615Rifabutin1Terminated1
DB01045Rifampicin1Completed11
DB01045Rifampicin1Not Yet Recruiting1
DB01045Rifampicin1Recruiting1
DB01045Rifampicin1Suspended1
DB01201Rifapentine1Completed4
DB00503Ritonavir1Completed1
DB00503Ritonavir1Terminated1
DB05186SQ-1091Completed2
DB05186SQ-1091Withdrawn1
DB09153Sodium Chloride1Recruiting1
DB00649Stavudine1Completed1
DB11905Sutezolid1Completed3
DB00300Tenofovir disoproxil1Completed1
DB00495Zidovudine1Completed1
DB06361rsPSMA Vaccine1Not Yet Recruiting1
DB12768BCG vaccine1 / 2Active Not Recruiting1
DB12768BCG vaccine1 / 2Not Yet Recruiting1
DB08903Bedaquiline1 / 2Recruiting1
DB11637Delamanid1 / 2Recruiting1
DB00224Indinavir1 / 2Completed1
DB00951Isoniazid1 / 2Recruiting1
DB06817Raltegravir1 / 2Recruiting1
DB01201Rifapentine1 / 2Recruiting1
DB00503Ritonavir1 / 2Completed1
DB01060Amoxicillin2Recruiting1
DB00995Auranofin2Recruiting1
DB12768BCG vaccine2Active Not Recruiting1
DB12768BCG vaccine2Completed2
DB12386Bacillus calmette-guerin substrain danish 1331 live antigen2Completed1
DB08903Bedaquiline2Active Not Recruiting1
DB08903Bedaquiline2Completed3
DB08903Bedaquiline2Not Yet Recruiting1
DB08903Bedaquiline2Recruiting1
DB10429Candida albicans2Completed3
DB00169Cholecalciferol2Recruiting1
DB00766Clavulanate2Recruiting1
DB11637Delamanid2Completed1
DB11637Delamanid2Recruiting1
DB08930Dolutegravir2Recruiting1
DB00254Doxycycline2Completed2
DB00625Efavirenz2Completed2
DB00625Efavirenz2Unknown Status1
DB00879Emtricitabine2Unknown Status1
DB00330Ethambutol2Completed1
DB00330Ethambutol2Not Yet Recruiting1
DB00330Ethambutol2Terminated1
DB00330Ethambutol2Unknown Status1
DB01590Everolimus2Recruiting1
DB12190Faropenem2Recruiting1
DB01050Ibuprofen2Enrolling by Invitation1
DB00951Isoniazid2Active Not Recruiting1
DB00951Isoniazid2Completed3
DB00951Isoniazid2Not Yet Recruiting1
DB00951Isoniazid2Recruiting3
DB00951Isoniazid2Suspended1
DB00951Isoniazid2Terminated1
DB00951Isoniazid2Unknown Status1
DB00125L-Arginine2Completed1
DB01601Lopinavir2Completed1
DB01601Lopinavir2Recruiting1
DB00916Metronidazole2Completed1
DB00218Moxifloxacin2Active Not Recruiting1
DB00218Moxifloxacin2Completed6
DB00218Moxifloxacin2Not Yet Recruiting1
DB00218Moxifloxacin2Unknown Status1
DB00507Nitazoxanide2Recruiting1
DB11768O-(2,4-dichlorophenyl)-O-methyl-isopropylphosphoramidothioate2Completed1
DB04850Posizolid2Completed1
DB09032Posizolid2Completed1
DB00860Prednisolone2Completed1
DB05154Pretomanid2Not Yet Recruiting1
DB01839Propylene glycol2Completed2
DB00339Pyrazinamide2Active Not Recruiting1
DB00339Pyrazinamide2Completed2
DB00339Pyrazinamide2Not Yet Recruiting1
DB00339Pyrazinamide2Recruiting1
DB00339Pyrazinamide2Terminated1
DB00339Pyrazinamide2Unknown Status1
DB06817Raltegravir2Completed1
DB06817Raltegravir2Terminated1
DB00615Rifabutin2Completed1
DB00615Rifabutin2Recruiting1
DB00615Rifabutin2Terminated1
DB00615Rifabutin2Unknown Status1
DB01045Rifampicin2Active Not Recruiting1
DB01045Rifampicin2Completed5
DB01045Rifampicin2Not Yet Recruiting1
DB01045Rifampicin2Terminated1
DB01045Rifampicin2Unknown Status1
DB01201Rifapentine2Completed2
DB01201Rifapentine2Unknown Status1
DB09153Sodium Chloride2Completed1
DB10286Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen2Completed1
DB01015Sulfamethoxazole2Completed1
DB11905Sutezolid2Completed1
DB00300Tenofovir disoproxil2Unknown Status1
DB01041Thalidomide2Completed1
DB00440Trimethoprim2Completed1
DB11601Tuberculin Purified Protein Derivative2Completed1
DB01076Atorvastatin2 / 3Withdrawn1
DB08903Bedaquiline2 / 3Recruiting1
DB06774Capsaicin2 / 3Withdrawn1
DB11131Capsicum oleoresin2 / 3Withdrawn1
DB01234Dexamethasone2 / 3Withdrawn1
DB00609Ethionamide2 / 3Recruiting1
DB00951Isoniazid2 / 3Completed1
DB00951Isoniazid2 / 3Not Yet Recruiting1
DB00951Isoniazid2 / 3Recruiting1
DB00951Isoniazid2 / 3Terminated1
DB01172Kanamycin2 / 3Recruiting1
DB01137Levofloxacin2 / 3Recruiting1
DB00281Lidocaine2 / 3Completed1
DB00601Linezolid2 / 3Recruiting1
DB00825Menthol2 / 3Withdrawn1
DB09543Methyl salicylate2 / 3Withdrawn1
DB00218Moxifloxacin2 / 3Recruiting1
DB00788Naproxen2 / 3Withdrawn1
DB00339Pyrazinamide2 / 3Recruiting1
DB00615Rifabutin2 / 3Completed1
DB01201Rifapentine2 / 3Not Yet Recruiting1
DB01015Sulfamethoxazole2 / 3Terminated1
DB12954Terizidone2 / 3Recruiting1
DB00440Trimethoprim2 / 3Terminated1
DB01048Abacavir3Completed1
DB12768BCG vaccine3Completed1
DB08903Bedaquiline3Recruiting1
DB11121Chloroxylenol3Recruiting1
DB00169Cholecalciferol3Unknown Status1
DB01234Dexamethasone3Not Yet Recruiting1
DB01234Dexamethasone3Recruiting1
DB00900Didanosine3Unknown Status1
DB00625Efavirenz3Completed2
DB00625Efavirenz3Recruiting1
DB00625Efavirenz3Unknown Status1
DB00879Emtricitabine3Completed1
DB00153Ergocalciferol3Unknown Status1
DB00330Ethambutol3Completed3
DB00330Ethambutol3Recruiting1
DB00330Ethambutol3Unknown Status1
DB00951Isoniazid3Completed9
DB00951Isoniazid3Recruiting3
DB00951Isoniazid3Unknown Status2
DB00167L-Isoleucine3Completed1
DB00167L-Isoleucine3Recruiting1
DB00172L-Proline3Completed1
DB00709Lamivudine3Completed1
DB00709Lamivudine3Recruiting1
DB00709Lamivudine3Unknown Status1
DB01137Levofloxacin3Completed1
DB00601Linezolid3Recruiting1
DB00218Moxifloxacin3Recruiting2
DB00238Nevirapine3Completed1
DB00238Nevirapine3Unknown Status1
DB00635Prednisone3Completed2
DB05154Pretomanid3Recruiting1
DB00339Pyrazinamide3Completed4
DB00339Pyrazinamide3Recruiting1
DB00339Pyrazinamide3Unknown Status1
DB00165Pyridoxine3Completed1
DB06817Raltegravir3Recruiting1
DB01045Rifampicin3Completed6
DB01045Rifampicin3Recruiting1
DB01045Rifampicin3Unknown Status1
DB01201Rifapentine3Completed3
DB01201Rifapentine3Recruiting4
DB00300Tenofovir disoproxil3Completed1
DB00300Tenofovir disoproxil3Recruiting1
DB11094Vitamin D3Unknown Status1
DB00495Zidovudine3Completed1
DB01593Zinc3Completed1
DB01048Abacavir4Completed1
DB01048Abacavir4Unknown Status1
DB06697Artemether4Unknown Status1
DB12768BCG vaccine4Completed1
DB00250Dapsone4Completed1
DB00625Efavirenz4Terminated3
DB00625Efavirenz4Unknown Status1
DB00442Entecavir4Unknown Status1
DB00330Ethambutol4Completed1
DB00951Isoniazid4Active Not Recruiting1
DB00951Isoniazid4Completed2
DB00951Isoniazid4Not Yet Recruiting1
DB00951Isoniazid4Recruiting1
DB00951Isoniazid4Unknown Status1
DB00709Lamivudine4Completed1
DB00709Lamivudine4Terminated1
DB00709Lamivudine4Unknown Status1
DB01601Lopinavir4Completed3
DB01601Lopinavir4Recruiting1
DB06708Lumefantrine4Unknown Status1
DB00333Methadone4Not Yet Recruiting1
DB00218Moxifloxacin4Terminated1
DB00704Naltrexone4Not Yet Recruiting1
DB00220Nelfinavir4Completed1
DB00238Nevirapine4Completed1
DB00238Nevirapine4Terminated1
DB00238Nevirapine4Unknown Status1
DB00339Pyrazinamide4Completed1
DB00165Pyridoxine4Recruiting1
DB06817Raltegravir4Unknown Status1
DB00615Rifabutin4Completed1
DB01045Rifampicin4Unknown Status1
DB01201Rifapentine4Not Yet Recruiting1
DB01201Rifapentine4Recruiting1
DB00503Ritonavir4Completed3
DB00503Ritonavir4Recruiting1
DB01015Sulfamethoxazole4Completed1
DB00300Tenofovir disoproxil4Terminated1
DB00440Trimethoprim4Completed1
DB00495Zidovudine4Completed1
DB00518AlbendazoleNot AvailableCompleted1
DB00479AmikacinNot AvailableCompleted1
DB00233Aminosalicylic AcidNot AvailableCompleted1
DB01072AtazanavirNot AvailableCompleted1
DB12768BCG vaccineNot AvailableTerminated1
DB12386Bacillus calmette-guerin substrain danish 1331 live antigenNot AvailableCompleted2
DB08903BedaquilineNot AvailableApproved for Marketing1
DB00314CapreomycinNot AvailableCompleted1
DB00314CapreomycinNot AvailableRecruiting1
DB00169CholecalciferolNot AvailableWithdrawn1
DB00845ClofazimineNot AvailableCompleted1
DB00260CycloserineNot AvailableCompleted1
DB00900DidanosineNot AvailableCompleted1
DB00625EfavirenzNot AvailableCompleted2
DB00625EfavirenzNot AvailableTerminated1
DB00625EfavirenzNot AvailableUnknown Status1
DB00879EmtricitabineNot AvailableTerminated1
DB00153ErgocalciferolNot AvailableCompleted1
DB00330EthambutolNot AvailableCompleted3
DB00609EthionamideNot AvailableCompleted1
DB10989Hepatitis A VaccineNot AvailableRecruiting1
DB00951IsoniazidNot AvailableCompleted8
DB00951IsoniazidNot AvailableRecruiting1
DB00951IsoniazidNot AvailableTerminated1
DB00951IsoniazidNot AvailableUnknown Status2
DB00709LamivudineNot AvailableCompleted2
DB01137LevofloxacinNot AvailableCompleted1
DB00281LidocaineNot AvailableUnknown Status1
DB00601LinezolidNot AvailableRecruiting1
DB00218MoxifloxacinNot AvailableRecruiting1
DB00704NaltrexoneNot AvailableCompleted1
DB00750PrilocaineNot AvailableUnknown Status1
DB00339PyrazinamideNot AvailableCompleted5
DB00165PyridoxineNot AvailableCompleted5
DB00615RifabutinNot AvailableActive Not Recruiting1
DB00615RifabutinNot AvailableCompleted2
DB00615RifabutinNot AvailableRecruiting1
DB00615RifabutinNot AvailableUnknown Status1
DB01045RifampicinNot AvailableCompleted6
DB01045RifampicinNot AvailableRecruiting1
DB01201RifapentineNot AvailableCompleted1
DB00503RitonavirNot AvailableCompleted1
DB01001SalbutamolNot AvailableUnknown Status1
DB09153Sodium ChlorideNot AvailableUnknown Status1
DB01082StreptomycinNot AvailableCompleted1
DB00300Tenofovir disoproxilNot AvailableTerminated1
DB11601Tuberculin Purified Protein DerivativeNot AvailableCompleted1
DB00495ZidovudineNot AvailableCompleted1