Identification
NameSt. John's Wort
Accession NumberDB01323
TypeSmall Molecule
GroupsNutraceutical
DescriptionNot Available
Structure
Thumb
Synonyms
Common st johnswort flowering top
Common st. john's wort flowering top
Common st. john's wort herb
Common st. johnswort flowering top
Guanyejinsitao
Hyperici herba
Hypericum nachitschevanicum flowering top
Hypericum perforatum flowering top
Hypoxis hemerocallidea root extract
Klamath weed flowering top
Klamathweed flowering top
Saint johns wort
St john's wort
St Johns Wort
St. johns wort
St. johnswort flowering top
External IDs Not Available
Product Ingredients Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Categories
UNIIUFH8805FKA
CAS number84082-80-4
WeightNot Available
Chemical FormulaNot Available
InChI KeyNot Available
InChINot Available
IUPAC NameNot Available
SMILESNot Available
Pharmacology
IndicationNot Available
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of actionNot Available
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe metabolism of 1,10-Phenanthroline can be increased when combined with St. John's Wort.Experimental
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with St. John's Wort.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with St. John's Wort.Experimental, Illicit
3,4-DichloroisocoumarinThe metabolism of 3,4-Dichloroisocoumarin can be increased when combined with St. John's Wort.Experimental
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe metabolism of 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE can be increased when combined with St. John's Wort.Experimental
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with St. John's Wort.Experimental, Illicit
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with St. John's Wort.Approved
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with St. John's Wort.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with St. John's Wort.Approved
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with St. John's Wort.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with St. John's Wort.Approved
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with St. John's Wort.Approved
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with St. John's Wort.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with St. John's Wort.Experimental
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with St. John's Wort.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with St. John's Wort.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with St. John's Wort.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with St. John's Wort.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with St. John's Wort.Approved
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with St. John's Wort.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be increased when combined with St. John's Wort.Approved
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with St. John's Wort.Approved, Withdrawn
Alpha-1-proteinase inhibitorThe metabolism of Alpha-1-proteinase inhibitor can be increased when combined with St. John's Wort.Approved
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with St. John's Wort.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with St. John's Wort.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with St. John's Wort.Approved
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with St. John's Wort.Approved
AmineptineThe metabolism of Amineptine can be increased when combined with St. John's Wort.Illicit, Withdrawn
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with St. John's Wort.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with St. John's Wort.Approved
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with St. John's Wort.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be increased when combined with St. John's Wort.Approved
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with St. John's Wort.Approved
AmprenavirThe metabolism of Amprenavir can be increased when combined with St. John's Wort.Approved
AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with St. John's Wort.Experimental, Illicit
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with St. John's Wort.Approved
Antithrombin III humanThe metabolism of Antithrombin III human can be increased when combined with St. John's Wort.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with St. John's Wort.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with St. John's Wort.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with St. John's Wort.Approved, Investigational
AprotininThe metabolism of Aprotinin can be increased when combined with St. John's Wort.Approved, Withdrawn
ArgatrobanThe metabolism of Argatroban can be increased when combined with St. John's Wort.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with St. John's Wort.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with St. John's Wort.Approved, Investigational
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with St. John's Wort resulting in a loss in efficacy.Approved
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with St. John's Wort.Approved
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with St. John's Wort.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with St. John's Wort.Approved, Investigational
AtenololThe serum concentration of Atenolol can be decreased when it is combined with St. John's Wort.Approved
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with St. John's Wort.Approved
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with St. John's Wort.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with St. John's Wort.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with St. John's Wort.Approved
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with St. John's Wort.Approved
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with St. John's Wort.Investigational
BatimastatThe metabolism of Batimastat can be increased when combined with St. John's Wort.Experimental
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with St. John's Wort.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with St. John's Wort.Approved
BenazeprilThe metabolism of Benazepril can be increased when combined with St. John's Wort.Approved, Investigational
BenzamidineThe metabolism of Benzamidine can be increased when combined with St. John's Wort.Experimental
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with St. John's Wort.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with St. John's Wort.Approved
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
BexaroteneThe serum concentration of Bexarotene can be decreased when it is combined with St. John's Wort.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with St. John's Wort.Approved
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with St. John's Wort.Approved
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with St. John's Wort.Approved
BivalirudinThe metabolism of Bivalirudin can be increased when combined with St. John's Wort.Approved, Investigational
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with St. John's Wort.Approved, Investigational
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with St. John's Wort.Approved, Investigational
BosentanThe serum concentration of Bosentan can be decreased when it is combined with St. John's Wort.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with St. John's Wort.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with St. John's Wort.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with St. John's Wort.Approved
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with St. John's Wort.Approved
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with St. John's Wort.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with St. John's Wort.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with St. John's Wort.Approved
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with St. John's Wort.Approved
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with St. John's Wort.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with St. John's Wort.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be decreased when it is combined with St. John's Wort.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with St. John's Wort.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with St. John's Wort.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with St. John's Wort.Approved
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with St. John's Wort.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with St. John's Wort.Approved
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with St. John's Wort.Approved
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with St. John's Wort.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with St. John's Wort.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with St. John's Wort.Approved
CandoxatrilThe metabolism of Candoxatril can be increased when combined with St. John's Wort.Experimental
CandoxatrilatThe metabolism of Candoxatrilat can be increased when combined with St. John's Wort.Experimental
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with St. John's Wort.Approved, Investigational
CaptoprilThe metabolism of Captopril can be increased when combined with St. John's Wort.Approved
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with St. John's Wort.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with St. John's Wort.Approved
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with St. John's Wort.Approved
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with St. John's Wort.Approved
CarisoprodolThe serum concentration of the active metabolites of Carisoprodol can be increased when Carisoprodol is used in combination with St. John's Wort.Approved
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with St. John's Wort.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with St. John's Wort.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with St. John's Wort.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with St. John's Wort.Approved
CerivastatinThe metabolism of Cerivastatin can be increased when combined with St. John's Wort.Withdrawn
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with St. John's Wort.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with St. John's Wort.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with St. John's Wort.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
ChlorotrianiseneThe therapeutic efficacy of Chlorotrianisene can be decreased when used in combination with St. John's Wort.Withdrawn
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with St. John's Wort.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with St. John's Wort.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with St. John's Wort.Approved, Nutraceutical
ChymostatinThe metabolism of Chymostatin can be increased when combined with St. John's Wort.Experimental
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with St. John's Wort.Approved, Investigational
CilastatinThe metabolism of Cilastatin can be increased when combined with St. John's Wort.Approved
CilazaprilThe metabolism of Cilazapril can be increased when combined with St. John's Wort.Approved
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with St. John's Wort.Approved
CimetidineThe serum concentration of Cimetidine can be decreased when it is combined with St. John's Wort.Approved
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with St. John's Wort.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with St. John's Wort.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with St. John's Wort.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with St. John's Wort.Approved
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with St. John's Wort.Approved
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with St. John's Wort.Approved
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with St. John's Wort.Approved, Illicit
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with St. John's Wort.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with St. John's Wort.Approved
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with St. John's Wort.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with St. John's Wort.Approved
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with St. John's Wort.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be increased when combined with St. John's Wort.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with St. John's Wort.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with St. John's Wort.Approved
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with St. John's Wort.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with St. John's Wort.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with St. John's Wort.Approved, Illicit
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with St. John's Wort.Approved
CobicistatThe serum concentration of Cobicistat can be decreased when it is combined with St. John's Wort.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with St. John's Wort.Approved
CocaineThe serum concentration of Cocaine can be decreased when it is combined with St. John's Wort.Approved, Illicit
CodeineThe serum concentration of Codeine can be decreased when it is combined with St. John's Wort.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with St. John's Wort.Approved
ConivaptanThe serum concentration of Conivaptan can be decreased when it is combined with St. John's Wort.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with St. John's Wort.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with St. John's Wort.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with St. John's Wort.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with St. John's Wort.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with St. John's Wort.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with St. John's Wort.Approved, Investigational
Dabigatran etexilateThe metabolism of Dabigatran etexilate can be increased when combined with St. John's Wort.Approved
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with St. John's Wort.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with St. John's Wort.Approved
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with St. John's Wort.Approved
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with St. John's Wort.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with St. John's Wort.Approved
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with St. John's Wort.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with St. John's Wort.Approved, Investigational
DarunavirThe metabolism of Darunavir can be increased when combined with St. John's Wort.Approved
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with St. John's Wort.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with St. John's Wort.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with St. John's Wort.Approved
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with St. John's Wort.Approved
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with St. John's Wort.Approved
DesipramineThe metabolism of Desipramine can be increased when combined with St. John's Wort.Approved
DesogestrelThe therapeutic efficacy of Desogestrel can be decreased when used in combination with St. John's Wort.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with St. John's Wort.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with St. John's Wort.Experimental, Vet Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with St. John's Wort.Approved
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with St. John's Wort.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with St. John's Wort.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with St. John's Wort.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be increased when combined with St. John's Wort.Approved
DienestrolThe therapeutic efficacy of Dienestrol can be decreased when used in combination with St. John's Wort.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with St. John's Wort.Approved
DiethylstilbestrolThe therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with St. John's Wort.Approved
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with St. John's Wort.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with St. John's Wort.Approved
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with St. John's Wort.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with St. John's Wort.Approved
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with St. John's Wort.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with St. John's Wort.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with St. John's Wort.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with St. John's Wort.Illicit
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with St. John's Wort.Approved
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with St. John's Wort.Approved
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with St. John's Wort.Approved
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with St. John's Wort.Approved
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with St. John's Wort.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with St. John's Wort.Approved
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with St. John's Wort.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with St. John's Wort.Approved
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with St. John's Wort.Approved
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with St. John's Wort.Approved
DosulepinThe metabolism of Dosulepin can be increased when combined with St. John's Wort.Approved
DoxepinThe metabolism of Doxepin can be increased when combined with St. John's Wort.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with St. John's Wort.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with St. John's Wort.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with St. John's Wort.Approved
DrospirenoneThe therapeutic efficacy of Drospirenone can be decreased when used in combination with St. John's Wort.Approved
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with St. John's Wort.Approved, Investigational
EcabetThe metabolism of Ecabet can be increased when combined with St. John's Wort.Approved, Investigational
EdoxabanThe metabolism of Edoxaban can be increased when combined with St. John's Wort.Approved
EfavirenzThe serum concentration of Efavirenz can be decreased when it is combined with St. John's Wort.Approved, Investigational
ElafinThe metabolism of Elafin can be increased when combined with St. John's Wort.Investigational
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with St. John's Wort.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with St. John's Wort.Approved
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with St. John's Wort.Approved
EnalaprilThe metabolism of Enalapril can be increased when combined with St. John's Wort.Approved, Vet Approved
EnalaprilatThe metabolism of Enalaprilat can be increased when combined with St. John's Wort.Approved
EnalkirenThe metabolism of Enalkiren can be increased when combined with St. John's Wort.Experimental
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with St. John's Wort.Approved
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with St. John's Wort.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with St. John's Wort.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with St. John's Wort.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with St. John's Wort.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with St. John's Wort.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with St. John's Wort.Approved
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with St. John's Wort.Approved
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with St. John's Wort.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with St. John's Wort.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with St. John's Wort.Approved, Investigational
EsmirtazapineThe metabolism of Esmirtazapine can be increased when combined with St. John's Wort.Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with St. John's Wort.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with St. John's Wort.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with St. John's Wort.Approved
EstriolThe serum concentration of Estriol can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
Estrogens, esterifiedThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with St. John's Wort.Approved
EstroneThe serum concentration of Estrone can be decreased when it is combined with St. John's Wort.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with St. John's Wort.Approved
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with St. John's Wort.Approved
EthanolThe serum concentration of Ethanol can be decreased when it is combined with St. John's Wort.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with St. John's Wort.Approved
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with St. John's Wort.Approved
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be increased when combined with St. John's Wort.Withdrawn
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with St. John's Wort.Approved, Illicit
Ethynodiol diacetateThe therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with St. John's Wort.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with St. John's Wort.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with St. John's Wort.Approved
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with St. John's Wort.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with St. John's Wort.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with St. John's Wort.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with St. John's Wort.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with St. John's Wort.Approved
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with St. John's Wort.Approved
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with St. John's Wort.Approved
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with St. John's Wort.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with St. John's Wort.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with St. John's Wort.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with St. John's Wort.Approved
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with St. John's Wort.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with St. John's Wort.Approved
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with St. John's Wort.Approved
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with St. John's Wort.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with St. John's Wort.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with St. John's Wort.Approved
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with St. John's Wort.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with St. John's Wort.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with St. John's Wort.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with St. John's Wort.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with St. John's Wort.Approved
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with St. John's Wort.Approved, Withdrawn
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with St. John's Wort.Approved
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with St. John's Wort.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with St. John's Wort.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with St. John's Wort.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with St. John's Wort.Approved
FluvastatinThe metabolism of Fluvastatin can be increased when combined with St. John's Wort.Approved
FormestaneThe serum concentration of Formestane can be decreased when it is combined with St. John's Wort.Approved, Investigational, Withdrawn
FosamprenavirThe metabolism of Fosamprenavir can be increased when combined with St. John's Wort.Approved
FosinoprilThe metabolism of Fosinopril can be increased when combined with St. John's Wort.Approved
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with St. John's Wort.Approved, Investigational
GabexateThe metabolism of Gabexate can be increased when combined with St. John's Wort.Investigational
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with St. John's Wort.Approved
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with St. John's Wort.Approved, Investigational
GeldanamycinThe metabolism of Geldanamycin can be increased when combined with St. John's Wort.Experimental
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with St. John's Wort.Approved
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with St. John's Wort.Approved
GestodeneThe therapeutic efficacy of Gestodene can be decreased when used in combination with St. John's Wort.Approved
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with St. John's Wort.Approved
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with St. John's Wort.Approved
GM6001The metabolism of GM6001 can be increased when combined with St. John's Wort.Experimental
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with St. John's Wort.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with St. John's Wort.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with St. John's Wort.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with St. John's Wort.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with St. John's Wort.Approved
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with St. John's Wort.Approved
HalothaneThe serum concentration of Halothane can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with St. John's Wort.Investigational
HexestrolThe therapeutic efficacy of Hexestrol can be decreased when used in combination with St. John's Wort.Withdrawn
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with St. John's Wort.Approved
HistamineThe serum concentration of Histamine Phosphate can be decreased when it is combined with St. John's Wort.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with St. John's Wort.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with St. John's Wort.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with St. John's Wort.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with St. John's Wort.Approved
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with St. John's Wort.Approved
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with St. John's Wort.Approved
IfosfamideThe serum concentration of Ifosfamide can be decreased when it is combined with St. John's Wort.Approved
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with St. John's Wort.Approved
ImatinibThe metabolism of Imatinib can be increased when combined with St. John's Wort.Approved
ImipramineThe metabolism of Imipramine can be increased when combined with St. John's Wort.Approved
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with St. John's Wort.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with St. John's Wort.Approved
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with St. John's Wort.Approved
IndinavirThe metabolism of Indinavir can be increased when combined with St. John's Wort.Approved
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with St. John's Wort.Approved, Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with St. John's Wort.Approved
IrinotecanThe therapeutic efficacy of Irinotecan can be decreased when used in combination with St. John's Wort.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with St. John's Wort resulting in a loss in efficacy.Approved, Investigational
IsoflurophateThe metabolism of Isoflurophate can be increased when combined with St. John's Wort.Approved, Withdrawn
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with St. John's Wort.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with St. John's Wort.Approved
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with St. John's Wort.Approved
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with St. John's Wort.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with St. John's Wort.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with St. John's Wort.Approved
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with St. John's Wort.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with St. John's Wort.Approved
KetamineThe serum concentration of Ketamine can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with St. John's Wort.Approved
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with St. John's Wort.Approved
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with St. John's Wort.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with St. John's Wort.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with St. John's Wort.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with St. John's Wort.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with St. John's Wort.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with St. John's Wort.Investigational
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with St. John's Wort.Approved
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with St. John's Wort.Approved
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with St. John's Wort.Approved
LepirudinThe metabolism of Lepirudin can be increased when combined with St. John's Wort.Approved
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with St. John's Wort.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with St. John's Wort.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with St. John's Wort.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with St. John's Wort.Approved
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with St. John's Wort.Approved
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with St. John's Wort.Approved, Investigational
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with St. John's Wort.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with St. John's Wort.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with St. John's Wort.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with St. John's Wort.Approved
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
LinagliptinThe metabolism of Linagliptin can be increased when combined with St. John's Wort.Approved
LisinoprilThe metabolism of Lisinopril can be increased when combined with St. John's Wort.Approved, Investigational
LisurideThe serum concentration of Lisuride can be decreased when it is combined with St. John's Wort.Approved
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with St. John's Wort.Approved
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with St. John's Wort.Approved
LopinavirThe metabolism of Lopinavir can be increased when combined with St. John's Wort.Approved
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with St. John's Wort.Approved
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with St. John's Wort.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with St. John's Wort.Approved
LovastatinThe metabolism of Lovastatin can be increased when combined with St. John's Wort.Approved, Investigational
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with St. John's Wort.Approved
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with St. John's Wort.Approved
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with St. John's Wort.Approved
MannitolThe serum concentration of Mannitol can be decreased when it is combined with St. John's Wort.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with St. John's Wort.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with St. John's Wort.Investigational
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with St. John's Wort.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with St. John's Wort.Approved
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with St. John's Wort.Approved
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
MestranolThe therapeutic efficacy of Mestranol can be decreased when used in combination with St. John's Wort.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with St. John's Wort.Approved
MethallenestrilThe therapeutic efficacy of Methallenestril can be decreased when used in combination with St. John's Wort.Experimental
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with St. John's Wort.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with St. John's Wort.Approved
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with St. John's Wort.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with St. John's Wort.Approved
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with St. John's Wort.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with St. John's Wort.Approved
MevastatinThe metabolism of Mevastatin can be increased when combined with St. John's Wort.Experimental
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with St. John's Wort.Approved
MianserinThe serum concentration of Mianserin can be decreased when it is combined with St. John's Wort.Approved
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with St. John's Wort.Withdrawn
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with St. John's Wort.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with St. John's Wort.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with St. John's Wort.Approved
MirtazapineThe metabolism of Mirtazapine can be increased when combined with St. John's Wort.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with St. John's Wort.Approved, Investigational
ModafinilThe serum concentration of Modafinil can be decreased when it is combined with St. John's Wort.Approved, Investigational
MoexiprilThe metabolism of Moexipril can be increased when combined with St. John's Wort.Approved
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with St. John's Wort.Approved
MorphineThe serum concentration of Morphine can be decreased when it is combined with St. John's Wort.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with St. John's Wort.Approved, Investigational
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe metabolism of N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline can be increased when combined with St. John's Wort.Experimental
NadololThe serum concentration of Nadolol can be decreased when it is combined with St. John's Wort.Approved
NafamostatThe metabolism of Nafamostat can be increased when combined with St. John's Wort.Approved, Investigational
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with St. John's Wort.Approved
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with St. John's Wort.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with St. John's Wort.Investigational
NCX 4016The metabolism of NCX 4016 can be increased when combined with St. John's Wort.Investigational
NefazodoneThe serum concentration of Nefazodone can be decreased when it is combined with St. John's Wort.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be increased when combined with St. John's Wort.Approved
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with St. John's Wort.Approved
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with St. John's Wort.Approved
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with St. John's Wort.Approved
NicotineThe serum concentration of Nicotine can be decreased when it is combined with St. John's Wort.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with St. John's Wort.Approved
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with St. John's Wort.Approved, Investigational
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with St. John's Wort.Approved
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with St. John's Wort.Approved
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with St. John's Wort.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with St. John's Wort.Approved
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with St. John's Wort.Approved
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with St. John's Wort.Approved
NizatidineThe serum concentration of Nizatidine can be decreased when it is combined with St. John's Wort.Approved
NorelgestrominThe therapeutic efficacy of Norelgestromin can be decreased when used in combination with St. John's Wort.Approved
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with St. John's Wort.Approved
NorgestimateThe therapeutic efficacy of Norgestimate can be decreased when used in combination with St. John's Wort.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with St. John's Wort.Approved
NortriptylineThe metabolism of Nortriptyline can be increased when combined with St. John's Wort.Approved
OlanzapineThe serum concentration of Olanzapine can be decreased when it is combined with St. John's Wort.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with St. John's Wort.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be decreased when it is combined with St. John's Wort.Investigational
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with St. John's Wort.Approved
OmapatrilatThe metabolism of Omapatrilat can be increased when combined with St. John's Wort.Investigational
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with St. John's Wort.Approved
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with St. John's Wort.Approved
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with St. John's Wort.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with St. John's Wort.Approved
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with St. John's Wort.Approved
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with St. John's Wort.Approved
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with St. John's Wort.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with St. John's Wort.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with St. John's Wort.Approved
PaliperidoneThe serum concentration of Paliperidone can be decreased when it is combined with St. John's Wort.Approved
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with St. John's Wort.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with St. John's Wort.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with St. John's Wort.Approved
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with St. John's Wort.Approved
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with St. John's Wort.Approved
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with St. John's Wort.Approved
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with St. John's Wort.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with St. John's Wort.Approved
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with St. John's Wort.Approved
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with St. John's Wort.Approved
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with St. John's Wort.Approved
PergolideThe serum concentration of Pergolide can be decreased when it is combined with St. John's Wort.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with St. John's Wort.Approved
PerindoprilThe metabolism of Perindopril can be increased when combined with St. John's Wort.Approved
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with St. John's Wort.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with St. John's Wort.Approved
PethidineThe serum concentration of Pethidine can be decreased when it is combined with St. John's Wort.Approved
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with St. John's Wort.Withdrawn
PhenindioneThe metabolism of Phenindione can be increased when combined with St. John's Wort.Approved
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with St. John's Wort.Approved
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with St. John's Wort.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with St. John's Wort.Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
PhosphoramidonThe metabolism of Phosphoramidon can be increased when combined with St. John's Wort.Experimental
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with St. John's Wort.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with St. John's Wort.Approved, Investigational
PimozideThe serum concentration of Pimozide can be decreased when it is combined with St. John's Wort.Approved
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with St. John's Wort.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with St. John's Wort.Approved
PitavastatinThe metabolism of Pitavastatin can be increased when combined with St. John's Wort.Approved
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with St. John's Wort.Approved
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with St. John's Wort.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with St. John's Wort.Approved
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be decreased when it is combined with St. John's Wort.Approved, Nutraceutical
Prasterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with St. John's Wort.Investigational
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with St. John's Wort.Approved
PravastatinThe metabolism of Pravastatin can be increased when combined with St. John's Wort.Approved
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with St. John's Wort.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with St. John's Wort.Approved
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with St. John's Wort.Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with St. John's Wort.Experimental
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with St. John's Wort.Approved
PrinomastatThe metabolism of Prinomastat can be increased when combined with St. John's Wort.Investigational
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with St. John's Wort.Approved
PromazineThe serum concentration of Promazine can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with St. John's Wort.Approved
PropofolThe serum concentration of Propofol can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be decreased when it is combined with St. John's Wort.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be increased when combined with St. John's Wort.Approved
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with St. John's Wort.Approved
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with St. John's Wort.Approved, Illicit
QuetiapineQuetiapine may increase the serotonergic activities of St. John's Wort.Approved
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with St. John's Wort.Approved
QuinaprilThe metabolism of Quinapril can be increased when combined with St. John's Wort.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with St. John's Wort.Approved
QuinineThe serum concentration of Quinine can be decreased when it is combined with St. John's Wort.Approved
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with St. John's Wort.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with St. John's Wort.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with St. John's Wort.Approved, Investigational
RamiprilThe metabolism of Ramipril can be increased when combined with St. John's Wort.Approved
RanitidineThe serum concentration of Ranitidine can be decreased when it is combined with St. John's Wort.Approved
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with St. John's Wort.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with St. John's Wort.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with St. John's Wort.Approved
RemikirenThe metabolism of Remikiren can be increased when combined with St. John's Wort.Approved
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with St. John's Wort.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be decreased when it is combined with St. John's Wort.Approved
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with St. John's Wort.Approved
RifabutinThe serum concentration of Rifabutin can be decreased when it is combined with St. John's Wort.Approved
RifampicinThe serum concentration of Rifampicin can be decreased when it is combined with St. John's Wort.Approved
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with St. John's Wort.Approved
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with St. John's Wort.Approved
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with St. John's Wort.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with St. John's Wort.Approved
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with St. John's Wort.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be increased when combined with St. John's Wort.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with St. John's Wort.Approved
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with St. John's Wort.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with St. John's Wort.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with St. John's Wort.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with St. John's Wort.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with St. John's Wort.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with St. John's Wort.Approved
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with St. John's Wort.Approved
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with St. John's Wort.Approved
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with St. John's Wort.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with St. John's Wort.Approved
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with St. John's Wort.Approved
SaquinavirThe metabolism of Saquinavir can be increased when combined with St. John's Wort.Approved, Investigational
SaxagliptinThe metabolism of Saxagliptin can be increased when combined with St. John's Wort.Approved
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with St. John's Wort.Approved
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with St. John's Wort.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be decreased when it is combined with St. John's Wort.Approved
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with St. John's Wort.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with St. John's Wort.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with St. John's Wort.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with St. John's Wort.Approved
SimvastatinThe metabolism of Simvastatin can be increased when combined with St. John's Wort.Approved
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with St. John's Wort.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be increased when combined with St. John's Wort.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with St. John's Wort.Approved
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with St. John's Wort.Approved
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with St. John's Wort.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with St. John's Wort.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with St. John's Wort.Approved
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with St. John's Wort.Experimental
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with St. John's Wort.Approved
SpiraprilThe metabolism of Spirapril can be increased when combined with St. John's Wort.Approved
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with St. John's Wort.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with St. John's Wort.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with St. John's Wort.Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with St. John's Wort.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with St. John's Wort.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with St. John's Wort.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with St. John's Wort.Approved
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with St. John's Wort.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with St. John's Wort.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with St. John's Wort.Approved
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with St. John's Wort.Approved, Investigational
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with St. John's Wort.Approved
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with St. John's Wort.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with St. John's Wort.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with St. John's Wort.Approved
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with St. John's Wort.Withdrawn
TelithromycinThe serum concentration of Telithromycin can be decreased when it is combined with St. John's Wort.Approved
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with St. John's Wort.Approved
TemocaprilThe metabolism of Temocapril can be increased when combined with St. John's Wort.Experimental, Investigational
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with St. John's Wort.Approved
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with St. John's Wort.Approved
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with St. John's Wort.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with St. John's Wort.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with St. John's Wort.Investigational
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with St. John's Wort.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with St. John's Wort.Approved
ThiorphanThe metabolism of Thiorphan can be increased when combined with St. John's Wort.Experimental
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with St. John's Wort.Approved
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with St. John's Wort.Approved
TianeptineThe metabolism of Tianeptine can be increased when combined with St. John's Wort.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with St. John's Wort resulting in a loss in efficacy.Approved
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with St. John's Wort.Approved
TimololThe serum concentration of Timolol can be decreased when it is combined with St. John's Wort.Approved
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with St. John's Wort.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with St. John's Wort.Approved
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with St. John's Wort.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with St. John's Wort.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with St. John's Wort.Approved, Investigational
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with St. John's Wort.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with St. John's Wort.Approved
TopotecanThe serum concentration of Topotecan can be decreased when it is combined with St. John's Wort.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with St. John's Wort.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with St. John's Wort.Approved, Investigational
TramadolThe serum concentration of Tramadol can be decreased when it is combined with St. John's Wort.Approved, Investigational
TrandolaprilThe metabolism of Trandolapril can be increased when combined with St. John's Wort.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with St. John's Wort.Approved
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with St. John's Wort.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with St. John's Wort.Approved
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with St. John's Wort.Approved
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be increased when combined with St. John's Wort.Approved
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with St. John's Wort.Withdrawn
UbenimexThe metabolism of Ubenimex can be increased when combined with St. John's Wort.Experimental
UbidecarenoneThe metabolism of Coenzyme Q10 can be increased when combined with St. John's Wort.Experimental
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with St. John's Wort.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with St. John's Wort.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with St. John's Wort.Approved
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with St. John's Wort.Investigational, Withdrawn
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with St. John's Wort.Approved
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with St. John's Wort.Investigational
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with St. John's Wort.Approved
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with St. John's Wort.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with St. John's Wort.Approved
VenetoclaxThe serum concentration of Venetoclax can be decreased when it is combined with St. John's Wort.Approved
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with St. John's Wort.Approved
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with St. John's Wort.Approved
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with St. John's Wort.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with St. John's Wort.Approved
VildagliptinThe metabolism of Vildagliptin can be increased when combined with St. John's Wort.Approved, Investigational
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with St. John's Wort.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with St. John's Wort.Approved, Investigational
VindesineThe serum concentration of Vindesine can be decreased when it is combined with St. John's Wort.Approved
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with St. John's Wort.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with St. John's Wort.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with St. John's Wort.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with St. John's Wort.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with St. John's Wort.Approved
WarfarinThe metabolism of Warfarin can be increased when combined with St. John's Wort.Approved
XimelagatranThe metabolism of Ximelagatran can be increased when combined with St. John's Wort.Approved, Investigational, Withdrawn
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with St. John's Wort.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with St. John's Wort.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with St. John's Wort.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with St. John's Wort.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with St. John's Wort.Approved
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with St. John's Wort.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with St. John's Wort.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with St. John's Wort.Approved
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with St. John's Wort.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with St. John's Wort.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with St. John's Wort.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with St. John's Wort.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

Trevor Percival Castor, Theodore Abraham Tyler, Richard Joseph Student, "Methods for making Hypericum fractions and St. John's Wort products." U.S. Patent US6291241, issued December, 1998.

US6291241
General References
  1. Lecrubier Y, Clerc G, Didi R, Kieser M: Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial. Am J Psychiatry. 2002 Aug;159(8):1361-6. [PubMed:12153829 ]
  2. Randlov C, Mehlsen J, Thomsen CF, Hedman C, von Fircks H, Winther K: The efficacy of St. John's Wort in patients with minor depressive symptoms or dysthymia--a double-blind placebo-controlled study. Phytomedicine. 2006 Mar;13(4):215-21. Epub 2006 Jan 19. [PubMed:16423519 ]
  3. Authors unspecified: Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial. JAMA. 2002 Apr 10;287(14):1807-14. [PubMed:11939866 ]
External Links
ATC CodesN06AX25
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableVA Drug Interactions [VA Drug Interaction]1
1CompletedPreventionChronic Hepatitis C Infection1
2CompletedTreatmentAnxiety Disorder / Major Depressive Disorder (MDD)1
2CompletedTreatmentAttention Deficit Hyperactivity Disorder (ADHD)1
2CompletedTreatmentIrritable Bowel Syndrome (IBS)1
2CompletedTreatmentNicotine Dependence / Smoking1
2TerminatedSupportive CareCancer, Breast / Menopausal Hot Flushes1
2, 3CompletedTreatmentAnxiety Disorder / Mental Health1
3CompletedTreatmentRaynaud's Disease1
3Not Yet RecruitingDiagnosticPeritoneal Carcinomatosis1
4CompletedDiagnosticPain1
4CompletedTreatmentHealthy Volunteers1
Not AvailableCompletedNot AvailableVA Drug Interactions [VA Drug Interaction]1
Not AvailableCompletedTreatmentDepressive State1
Not AvailableCompletedTreatmentMajor Depressive Disorder (MDD)1
Not AvailableTerminatedTreatmentAcute Coronary Syndromes (ACS)1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted PropertiesNot Available
Predicted ADMET featuresNot Available
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Taxonomy
ClassificationNot classified

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Wenk M, Todesco L, Krahenbuhl S: Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females. Br J Clin Pharmacol. 2004 Apr;57(4):495-9. [PubMed:15025748 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Durr D, Stieger B, Kullak-Ublick GA, Rentsch KM, Steinert HC, Meier PJ, Fattinger K: St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin Pharmacol Ther. 2000 Dec;68(6):598-604. [PubMed:11180019 ]
Drug created on June 30, 2007 11:20 / Updated on February 24, 2017 09:25