Identification

Name
Prucalopride
Accession Number
DB06480
Type
Small Molecule
Groups
Approved
Description

Prucalopride (brand name Resolor, developed by Johnson & Johnson and licensed to Movetis) is a drug acting as a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalising bowel movements. Prucalopride was approved for use in Europe in 2009 and in Canada (named Resotran) on December 7, 2011 but it has not been approved by the Food and Drug Administration for use in the United States. The drug has also been tested for the treatment of chronic intestinal pseudo-obstruction.

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Prucalopride hydrochlorideM8IYX9Z79V179474-80-7KKMOQGWTJRGLNN-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ResotranTablet1 mgOralJanssen Pharmaceuticals2012-01-12Not applicableCanada
ResotranTablet2 mgOralJanssen Pharmaceuticals2012-01-12Not applicableCanada
International/Other Brands
Resolor
Categories
UNII
0A09IUW5TP
CAS number
179474-81-8
Weight
Average: 367.87
Monoisotopic: 367.1662694
Chemical Formula
C18H26ClN3O3
InChI Key
ZPMNHBXQOOVQJL-UHFFFAOYSA-N
InChI
InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
IUPAC Name
4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide
SMILES
COCCCN1CCC(CC1)NC(=O)C1=C2OCCC2=C(N)C(Cl)=C1

Pharmacology

Indication

Investigated for use/treatment in constipation, ileus, and pediatric indications.

Structured Indications
Pharmacodynamics
Not Available
Mechanism of action

Prucalopride (PRU) is a selective high affinity 5-HT4 agonist, which are involved in initiating peristalsis. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation.

TargetActionsOrganism
A5-hydroxytryptamine receptor 4
agonist
Human
Absorption

Prucalopride is rapidly absorbed (Cmax attained 2–3 hours after single 2 mg oral dose) and is extensively distributed.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

In vitro, human liver metabolism is very slow and only minor amounts of metabolites are found.

Route of elimination
Not Available
Half life

Terminal half-life is 24–30 hours.

Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AbemaciclibThe serum concentration of Prucalopride can be increased when it is combined with Abemaciclib.Approved
AcetaminophenThe serum concentration of Prucalopride can be increased when it is combined with Acetaminophen.Approved
AfatinibThe serum concentration of Prucalopride can be increased when it is combined with Afatinib.Approved
AlbendazoleThe serum concentration of Prucalopride can be increased when it is combined with Albendazole.Approved, Vet Approved
AlectinibThe serum concentration of Prucalopride can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Prucalopride can be increased when it is combined with Alfentanil.Approved, Illicit
AmantadineThe serum concentration of Prucalopride can be increased when it is combined with Amantadine.Approved
Aminohippuric acidThe serum concentration of Prucalopride can be increased when it is combined with Aminohippuric acid.Approved, Investigational
AmiodaroneThe serum concentration of Prucalopride can be increased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Prucalopride can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Prucalopride can be increased when it is combined with Amlodipine.Approved
AmprenavirThe serum concentration of Prucalopride can be increased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Prucalopride can be increased when it is combined with Amsacrine.Approved
AstemizoleThe serum concentration of Prucalopride can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe serum concentration of Prucalopride can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Prucalopride can be increased when it is combined with Atenolol.Approved
AtorvastatinThe serum concentration of Prucalopride can be increased when it is combined with Atorvastatin.Approved
AzelastineThe serum concentration of Prucalopride can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Prucalopride can be increased when it is combined with Azithromycin.Approved
BenzocaineThe serum concentration of Prucalopride can be increased when it is combined with Benzocaine.Approved
BepridilThe serum concentration of Prucalopride can be increased when it is combined with Bepridil.Approved, Withdrawn
BiperidenThe serum concentration of Prucalopride can be increased when it is combined with Biperiden.Approved, Investigational
BoceprevirThe serum concentration of Prucalopride can be increased when it is combined with Boceprevir.Approved, Withdrawn
BosutinibThe serum concentration of Prucalopride can be increased when it is combined with Bosutinib.Approved
BromocriptineThe serum concentration of Prucalopride can be increased when it is combined with Bromocriptine.Approved, Investigational
BuprenorphineThe serum concentration of Prucalopride can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Prucalopride can be increased when it is combined with Buspirone.Approved, Investigational
CabazitaxelThe serum concentration of Prucalopride can be increased when it is combined with Cabazitaxel.Approved
CaffeineThe serum concentration of Prucalopride can be increased when it is combined with Caffeine.Approved
CanagliflozinThe serum concentration of Prucalopride can be increased when it is combined with Canagliflozin.Approved
CandesartanThe serum concentration of Prucalopride can be increased when it is combined with Candesartan.Experimental
Candesartan cilexetilThe serum concentration of Prucalopride can be increased when it is combined with Candesartan cilexetil.Approved
CaptoprilThe serum concentration of Prucalopride can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Prucalopride can be increased when it is combined with Carbamazepine.Approved, Investigational
CarvedilolThe serum concentration of Prucalopride can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Prucalopride can be increased when it is combined with Caspofungin.Approved
ChloroquineThe serum concentration of Prucalopride can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Prucalopride.Investigational, Withdrawn
ChlorpromazineThe serum concentration of Prucalopride can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Prucalopride can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Prucalopride can be increased when it is combined with Chlorprothixene.Approved, Investigational, Withdrawn
CholesterolThe serum concentration of Prucalopride can be increased when it is combined with Cholesterol.Experimental, Investigational
CilazaprilThe serum concentration of Prucalopride can be increased when it is combined with Cilazapril.Approved
CimetidineThe serum concentration of Prucalopride can be increased when it is combined with Cimetidine.Approved
CiprofloxacinThe serum concentration of Prucalopride can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CitalopramThe serum concentration of Prucalopride can be increased when it is combined with Citalopram.Approved
ClarithromycinThe serum concentration of Prucalopride can be increased when it is combined with Clarithromycin.Approved
ClofazimineThe serum concentration of Prucalopride can be increased when it is combined with Clofazimine.Approved, Investigational
ClomipramineThe serum concentration of Prucalopride can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClotrimazoleThe serum concentration of Prucalopride can be increased when it is combined with Clotrimazole.Approved, Vet Approved
CobicistatThe serum concentration of Prucalopride can be increased when it is combined with Cobicistat.Approved
ColchicineThe serum concentration of Prucalopride can be increased when it is combined with Colchicine.Approved
ColforsinThe serum concentration of Prucalopride can be increased when it is combined with Colforsin.Experimental, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be decreased when it is combined with Prucalopride.Approved
CrizotinibThe serum concentration of Prucalopride can be increased when it is combined with Crizotinib.Approved
CyclophosphamideThe serum concentration of Prucalopride can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Prucalopride can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
DaclatasvirThe serum concentration of Prucalopride can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Prucalopride can be increased when it is combined with Dactinomycin.Approved
DasatinibThe serum concentration of Prucalopride can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Prucalopride can be increased when it is combined with Daunorubicin.Approved
DesipramineThe serum concentration of Prucalopride can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Prucalopride can be increased when it is combined with Desloratadine.Approved, Investigational
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Prucalopride.Approved
DexamethasoneThe serum concentration of Prucalopride can be increased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Prucalopride can be increased when it is combined with Dextromethorphan.Approved
DiclofenacThe serum concentration of Prucalopride can be increased when it is combined with Diclofenac.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Prucalopride.Approved, Investigational
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Prucalopride.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Prucalopride.Approved, Investigational
DigoxinThe serum concentration of Prucalopride can be increased when it is combined with Digoxin.Approved
DihydroergotamineThe serum concentration of Prucalopride can be increased when it is combined with Dihydroergotamine.Approved
DiltiazemThe serum concentration of Prucalopride can be increased when it is combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Prucalopride can be increased when it is combined with Dipyridamole.Approved
DoxazosinThe serum concentration of Prucalopride can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Prucalopride can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Prucalopride can be increased when it is combined with Doxorubicin.Approved, Investigational
DronabinolThe serum concentration of Prucalopride can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe serum concentration of Prucalopride can be increased when it is combined with Dronedarone.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Prucalopride.Approved
EnalaprilThe serum concentration of Prucalopride can be increased when it is combined with Enalapril.Approved, Vet Approved
EnasidenibThe serum concentration of Prucalopride can be increased when it is combined with Enasidenib.Approved
EnzalutamideThe serum concentration of Prucalopride can be increased when it is combined with Enzalutamide.Approved
ErgonovineThe serum concentration of Prucalopride can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Prucalopride can be increased when it is combined with Ergotamine.Approved
ErythromycinThe serum concentration of Prucalopride can be increased when it is combined with Erythromycin.Approved, Vet Approved
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Prucalopride.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Prucalopride.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Prucalopride.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Prucalopride.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Prucalopride.Approved
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Prucalopride.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Prucalopride.Approved, Investigational
EtoposideThe serum concentration of Prucalopride can be increased when it is combined with Etoposide.Approved
EtravirineThe serum concentration of Prucalopride can be increased when it is combined with Etravirine.Approved
FelodipineThe serum concentration of Prucalopride can be increased when it is combined with Felodipine.Approved, Investigational
FentanylThe serum concentration of Prucalopride can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe serum concentration of Prucalopride can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Prucalopride can be increased when it is combined with Fidaxomicin.Approved
FluconazoleThe serum concentration of Prucalopride can be increased when it is combined with Fluconazole.Approved
FluoxetineThe serum concentration of Prucalopride can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Prucalopride can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Prucalopride can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Prucalopride can be increased when it is combined with Flurazepam.Approved, Illicit
FluvoxamineThe serum concentration of Prucalopride can be increased when it is combined with Fluvoxamine.Approved, Investigational
GefitinibThe serum concentration of Prucalopride can be increased when it is combined with Gefitinib.Approved, Investigational
GenisteinThe serum concentration of Prucalopride can be increased when it is combined with Genistein.Investigational
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Prucalopride.Approved, Investigational
GlecaprevirThe serum concentration of Prucalopride can be increased when it is combined with Glecaprevir.Approved
GlyburideThe serum concentration of Prucalopride can be increased when it is combined with Glyburide.Approved
GlycerinThe serum concentration of Prucalopride can be increased when it is combined with Glycerin.Approved, Investigational
Gramicidin DThe serum concentration of Prucalopride can be increased when it is combined with Gramicidin D.Approved
GrepafloxacinThe serum concentration of Prucalopride can be increased when it is combined with Grepafloxacin.Investigational, Withdrawn
HaloperidolThe serum concentration of Prucalopride can be increased when it is combined with Haloperidol.Approved
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Prucalopride.Withdrawn
HydrocortisoneThe serum concentration of Prucalopride can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
IdelalisibThe serum concentration of Prucalopride can be increased when it is combined with Idelalisib.Approved
ImatinibThe serum concentration of Prucalopride can be increased when it is combined with Imatinib.Approved
ImipramineThe serum concentration of Prucalopride can be increased when it is combined with Imipramine.Approved
IndinavirThe serum concentration of Prucalopride can be increased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Prucalopride can be increased when it is combined with Indomethacin.Approved, Investigational
IsavuconazoniumThe serum concentration of Prucalopride can be increased when it is combined with Isavuconazonium.Approved, Investigational
ItraconazoleThe serum concentration of Prucalopride can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Prucalopride can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Prucalopride can be increased when it is combined with Ivermectin.Approved, Vet Approved
KetamineThe serum concentration of Prucalopride can be increased when it is combined with Ketamine.Approved, Vet Approved
KetoconazoleThe serum concentration of Prucalopride can be increased when it is combined with Ketoconazole.Approved, Investigational
LansoprazoleThe serum concentration of Prucalopride can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Prucalopride can be increased when it is combined with Lapatinib.Approved, Investigational
LetermovirThe serum concentration of Prucalopride can be increased when it is combined with Letermovir.Approved
LevofloxacinThe serum concentration of Prucalopride can be increased when it is combined with Levofloxacin.Approved, Investigational
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Prucalopride.Approved, Investigational
LidocaineThe serum concentration of Prucalopride can be increased when it is combined with Lidocaine.Approved, Vet Approved
LomitapideThe serum concentration of Prucalopride can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Prucalopride can be increased when it is combined with Loperamide.Approved
LopinavirThe serum concentration of Prucalopride can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Prucalopride can be increased when it is combined with Loratadine.Approved
LosartanThe serum concentration of Prucalopride can be increased when it is combined with Losartan.Approved
LovastatinThe serum concentration of Prucalopride can be increased when it is combined with Lovastatin.Approved, Investigational
LumacaftorThe serum concentration of Prucalopride can be increased when it is combined with Lumacaftor.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Prucalopride.Investigational
MaprotilineThe serum concentration of Prucalopride can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Prucalopride can be increased when it is combined with Mebendazole.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Prucalopride.Approved, Investigational
MefloquineThe serum concentration of Prucalopride can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Prucalopride can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MeprobamateThe serum concentration of Prucalopride can be increased when it is combined with Meprobamate.Approved, Illicit
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Prucalopride.Approved
MethadoneThe serum concentration of Prucalopride can be increased when it is combined with Methadone.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Prucalopride.Experimental
MetoprololThe serum concentration of Prucalopride can be increased when it is combined with Metoprolol.Approved, Investigational
MibefradilThe serum concentration of Prucalopride can be increased when it is combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe serum concentration of Prucalopride can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Prucalopride can be increased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Prucalopride can be increased when it is combined with Mifepristone.Approved, Investigational
MitomycinThe serum concentration of Prucalopride can be increased when it is combined with Mitomycin.Approved
MitoxantroneThe serum concentration of Prucalopride can be increased when it is combined with Mitoxantrone.Approved, Investigational
MorphineThe serum concentration of Prucalopride can be increased when it is combined with Morphine.Approved, Investigational
NaltrexoneThe serum concentration of Prucalopride can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Prucalopride can be increased when it is combined with Naringenin.Experimental
NelfinavirThe serum concentration of Prucalopride can be increased when it is combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Prucalopride can be increased when it is combined with Neostigmine.Approved, Vet Approved
NicardipineThe serum concentration of Prucalopride can be increased when it is combined with Nicardipine.Approved
NifedipineThe serum concentration of Prucalopride can be increased when it is combined with Nifedipine.Approved
NilotinibThe serum concentration of Prucalopride can be increased when it is combined with Nilotinib.Approved, Investigational
NisoldipineThe serum concentration of Prucalopride can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Prucalopride can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Prucalopride can be increased when it is combined with Nitrendipine.Approved, Investigational
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Prucalopride.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Prucalopride.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Prucalopride.Approved
OmeprazoleThe serum concentration of Prucalopride can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Prucalopride can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Prucalopride can be increased when it is combined with Paclitaxel.Approved, Vet Approved
Palmitic AcidThe serum concentration of Prucalopride can be increased when it is combined with Palmitic Acid.Approved, Experimental
PantoprazoleThe serum concentration of Prucalopride can be increased when it is combined with Pantoprazole.Approved
ParoxetineThe serum concentration of Prucalopride can be increased when it is combined with Paroxetine.Approved, Investigational
PerindoprilThe serum concentration of Prucalopride can be increased when it is combined with Perindopril.Approved
PibrentasvirThe serum concentration of Prucalopride can be increased when it is combined with Pibrentasvir.Approved
PimozideThe serum concentration of Prucalopride can be increased when it is combined with Pimozide.Approved
PonatinibThe serum concentration of Prucalopride can be increased when it is combined with Ponatinib.Approved
PosaconazoleThe serum concentration of Prucalopride can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PravastatinThe serum concentration of Prucalopride can be increased when it is combined with Pravastatin.Approved
PrazosinThe serum concentration of Prucalopride can be increased when it is combined with Prazosin.Approved
PrednisoneThe serum concentration of Prucalopride can be increased when it is combined with Prednisone.Approved, Vet Approved
ProbenecidThe serum concentration of Prucalopride can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Prucalopride can be increased when it is combined with Progesterone.Approved, Vet Approved
PromethazineThe serum concentration of Prucalopride can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Prucalopride can be increased when it is combined with Propafenone.Approved
PropranololThe serum concentration of Prucalopride can be increased when it is combined with Propranolol.Approved, Investigational
ProtriptylineThe serum concentration of Prucalopride can be increased when it is combined with Protriptyline.Approved
QuercetinThe serum concentration of Prucalopride can be increased when it is combined with Quercetin.Experimental, Investigational
QuinacrineThe serum concentration of Prucalopride can be increased when it is combined with Quinacrine.Approved, Investigational
QuinidineThe serum concentration of Prucalopride can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Prucalopride can be increased when it is combined with Quinine.Approved
RanitidineThe serum concentration of Prucalopride can be increased when it is combined with Ranitidine.Approved
ReboxetineThe serum concentration of Prucalopride can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Prucalopride can be increased when it is combined with Regorafenib.Approved
ReserpineThe serum concentration of Prucalopride can be increased when it is combined with Reserpine.Approved, Investigational
RifampicinThe serum concentration of Prucalopride can be increased when it is combined with Rifampicin.Approved
RilpivirineThe serum concentration of Prucalopride can be increased when it is combined with Rilpivirine.Approved
RitonavirThe serum concentration of Prucalopride can be increased when it is combined with Ritonavir.Approved, Investigational
RolapitantThe serum concentration of Prucalopride can be increased when it is combined with Rolapitant.Approved
SaquinavirThe serum concentration of Prucalopride can be increased when it is combined with Saquinavir.Approved, Investigational
ScopolamineThe serum concentration of Prucalopride can be increased when it is combined with Scopolamine.Approved
SelegilineThe serum concentration of Prucalopride can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SertralineThe serum concentration of Prucalopride can be increased when it is combined with Sertraline.Approved
SimeprevirThe serum concentration of Prucalopride can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Prucalopride can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Prucalopride can be increased when it is combined with Sirolimus.Approved, Investigational
SorafenibThe serum concentration of Prucalopride can be increased when it is combined with Sorafenib.Approved, Investigational
SpironolactoneThe serum concentration of Prucalopride can be increased when it is combined with Spironolactone.Approved
StaurosporineThe serum concentration of Prucalopride can be increased when it is combined with Staurosporine.Experimental
SulfinpyrazoneThe serum concentration of Prucalopride can be increased when it is combined with Sulfinpyrazone.Approved
SumatriptanThe serum concentration of Prucalopride can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Prucalopride can be increased when it is combined with Sunitinib.Approved, Investigational
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Prucalopride.Approved
TacrineThe serum concentration of Prucalopride can be increased when it is combined with Tacrine.Investigational, Withdrawn
TacrolimusThe serum concentration of Prucalopride can be increased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of Prucalopride can be increased when it is combined with Tamoxifen.Approved
Taurocholic AcidThe serum concentration of Prucalopride can be increased when it is combined with Taurocholic Acid.Experimental
TelaprevirThe serum concentration of Prucalopride can be increased when it is combined with Telaprevir.Approved, Withdrawn
TelmisartanThe serum concentration of Prucalopride can be increased when it is combined with Telmisartan.Approved, Investigational
TemsirolimusThe serum concentration of Prucalopride can be increased when it is combined with Temsirolimus.Approved
TerazosinThe serum concentration of Prucalopride can be increased when it is combined with Terazosin.Approved
TerfenadineThe serum concentration of Prucalopride can be increased when it is combined with Terfenadine.Withdrawn
TestosteroneThe serum concentration of Prucalopride can be increased when it is combined with Testosterone.Approved, Investigational
TicagrelorThe serum concentration of Prucalopride can be increased when it is combined with Ticagrelor.Approved
TolvaptanThe serum concentration of Prucalopride can be increased when it is combined with Tolvaptan.Approved
TrifluoperazineThe serum concentration of Prucalopride can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Prucalopride can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Prucalopride can be increased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Prucalopride can be increased when it is combined with Trimipramine.Approved
TroleandomycinThe serum concentration of Prucalopride can be increased when it is combined with Troleandomycin.Approved
VelpatasvirThe serum concentration of Prucalopride can be increased when it is combined with Velpatasvir.Approved
VenlafaxineThe serum concentration of Prucalopride can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Prucalopride can be increased when it is combined with Verapamil.Approved
VinblastineThe serum concentration of Prucalopride can be increased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Prucalopride can be increased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Prucalopride can be increased when it is combined with Vinorelbine.Approved, Investigational
VoxilaprevirThe serum concentration of Prucalopride can be increased when it is combined with Voxilaprevir.Approved
ZimelidineThe serum concentration of Prucalopride can be increased when it is combined with Zimelidine.Withdrawn
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
3052762
PubChem Substance
310264873
ChemSpider
2314539
BindingDB
50122872
ChEBI
135552
ChEMBL
CHEMBL117287
Wikipedia
Prucalopride
ATC Codes
A06AX05 — Prucalopride
AHFS Codes
  • 56:92.00 — Miscellaneous GI Drugs

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHealthy Volunteers1
1CompletedNot AvailableOccasional Constipation1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedTreatmentHealthy Volunteers1
1CompletedTreatmentHepatic Impairment1
1CompletedTreatmentOccasional Constipation4
1, 2CompletedNot AvailableFunctional Constipation1
2CompletedTreatmentChronic Constipation1
2CompletedTreatmentOccasional Constipation5
2CompletedTreatmentPostoperative paralytic ileus1
2Enrolling by InvitationTreatmentIneffective Esophageal Motility / Swallowing Disorders1
2, 3RecruitingTreatmentDiabetes Mellitus (DM) / Gastroparesis1
3CompletedDiagnosticBowel preparation therapy / Colon Capsule Completion Times1
3CompletedDiagnosticColon Capsule Completion Rates / Colon Capsule Polyp Detection / Quality of Bowel Preparation for the Colon Capsule1
3CompletedTreatmentChronic Constipation2
3CompletedTreatmentFunctional Constipation1
3CompletedTreatmentMale Subjects With Chronic Constipation1
3CompletedTreatmentOccasional Constipation8
3RecruitingPreventionPostoperative Complications / Postoperative paralytic ileus / Surgery, Colorectal1
3TerminatedTreatmentNon-cancer Pain / Opioid Induced Constipation (OIC)1
4CompletedOtherChronic Constipation1
4CompletedTreatmentChronic Constipation1
4CompletedTreatmentOccasional Constipation2
4Not Yet RecruitingTreatmentCrohn's Disease (CD) / Gluten Enteropathy / Hemorrhage, Gastrointestinal / Inflammatory Bowel Diseases (IBD) / Intestinal Diseases1
4RecruitingTreatmentGastroparesis1
4RecruitingTreatmentPostoperative paralytic ileus1
4WithdrawnNot AvailableChronic Constipation1
Not AvailableCompletedTreatmentOccasional Constipation1
Not AvailableSuspendedNot AvailableOccasional Constipation1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TabletOral1 mg
TabletOral2 mg
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.129 mg/mLALOGPS
logP2.09ALOGPS
logP0.74ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)14.64ChemAxon
pKa (Strongest Basic)8.98ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area76.82 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity100.67 m3·mol-1ChemAxon
Polarizability39.08 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as aminobenzamides. These are organic compounds containing a benzamide moiety with an amine group attached to the benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzoic acids and derivatives
Direct Parent
Aminobenzamides
Alternative Parents
Coumarans / Alkyl aryl ethers / Piperidines / Aryl chlorides / Trialkylamines / Secondary carboxylic acid amides / Amino acids and derivatives / Oxacyclic compounds / Dialkyl ethers / Azacyclic compounds
show 5 more
Substituents
Aminobenzamide / Coumaran / Alkyl aryl ether / Aryl chloride / Aryl halide / Piperidine / Amino acid or derivatives / Carboxamide group / Secondary carboxylic acid amide / Tertiary aliphatic amine
show 19 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Serotonin receptor activity
Specific Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor ...
Gene Name
HTR4
Uniprot ID
Q13639
Uniprot Name
5-hydroxytryptamine receptor 4
Molecular Weight
43760.975 Da
References
  1. Briejer MR, Bosmans JP, Van Daele P, Jurzak M, Heylen L, Leysen JE, Prins NH, Schuurkes JA: The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83. [PubMed:11438309]

Drug created on March 19, 2008 10:34 / Updated on November 19, 2017 20:34