Calcium gluconate


Calcium gluconate
Accession Number
Small Molecule
Approved, Vet approved

Calcium gluconate is a mineral supplement and medication. Supplementation is generally only required when there is not enough calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injection, USP is a sterile, nonpyrogenic supersaturated solution of calcium gluconate for intravenous use only. Each mL contains: Calcium gluconate 94 mg; calcium saccharate (tetrahydrate) 4.5 mg; water for injection q.s. Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (6.0 to 8.2). Calcium saccharate provides 6% of the total calcium and stabilizes the supersaturated solution of calcium gluconate. Each 10 mL of the injection provides 93 mg elemental calcium (Ca++) equivalent to 1 g of calcium gluconate.

  • Calcarea gluconica
  • Calcii gluconas
  • Calcio gluconato
  • Calcium di-gluconate
  • Calcium gluconate anhydrous
  • Calcium gluconate, anhydrous
  • D-gluconic acid, calcium salt (2:1)
External IDs
E-578 / INS NO.578 / INS-578
Product Ingredients
IngredientUNIICASInChI Key
Calcium gluconate monohydrateCZN0MI5R3166905-23-5XLNFVCRGJZBQGX-XRDLMGPZSA-L
Active Moieties
Calcium cationionic2M83C4R6ZB14127-61-8BHPQYMZQTOCNFJ-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Calcium GluconateInjection, solution98 mg/1mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2018-12-21Not applicableUs
Calcium GluconateInjection, solution20 mg/1mLIntravenousWG Critical Care, LLC2018-10-26Not applicableUs
Calcium GluconateInjection, solution98 mg/1mLIntravenousGeneral Injectables and Vaccines, Inc.2018-02-12Not applicableUs
Calcium GluconateInjection, solution20 mg/1mLIntravenousWG Critical Care, LLC2018-10-26Not applicableUs
Calcium GluconateInjection, solution98 mg/1mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2018-10-18Not applicableUs
Calcium GluconateInjection, solution98 mg/1mLIntravenousA-S Medication Solutions2017-06-15Not applicableUs
Calcium GluconateInjection, solution98 mg/1mLIntravenousFresenius Kabi USA, LLC2017-06-15Not applicableUs
Calcium Gluconate 10% Inj 100mg/mlLiquid100 mgIntravenousAstra Zeneca1986-12-312004-11-01Canada
Calcium Gluconate Inj 10%Solution100 mgIntravenousLyphomed, Division Of Fujisawa Canada Inc.1992-12-311996-09-10Canada
Calcium Gluconate Inj 100mg/mlSolution100 mgIntramuscular; IntravenousHospira, Inc.1981-12-312010-11-05Canada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Calcium Gluconate Tab 600mgTablet600 mgOralSwiss Herbal Remedies Ltd.1983-12-312003-09-10Canada
Calcium Gluconate Tab 648mgTablet648 mgOralPharmetics (2011) Inc.1973-12-312000-08-21Canada
Calcium Gluconate Tab 648mgTablet648 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Calcium Gluconate Tab 648mg USPTablet648 mgOralLab Gernetic Int Ltee1985-12-311997-02-21Canada
Calcium Gluconate Tab 650mgTablet650 mgOralVita Health Products Inc1972-12-312002-07-31Canada
Calcium Gluconate Tab 650mgTablet650 mgOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1979-12-311996-09-09Canada
Calcium Gluconate Tab 650mgTablet650 mgOralD.C. Labs Limited1969-12-312005-07-19Canada
Calcium Gluconate Tab 650mgTablet650 mgOralShoppers Drug Mart Inc.1978-12-311997-08-15Canada
Calcium Gluconate Tablets 648mg USPTablet648 mgOralVita Health Products Inc1988-12-312002-07-31Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Calcium Gluconate Injection, USP 10%Calcium gluconate (94 mg) + Calcium saccharate (4.5 mg)SolutionIntravenousFresenius Kabi1984-07-19Not applicableCanada
Calcium LiquidCalcium gluconate (112 mg) + Calcium glucoheptonate (132 mg)LiquidOralKsl Pharmaceuticals1994-12-311996-09-09Canada
Calcium LiquidCalcium gluconate (112 mg) + Calcium glucoheptonate (132 mg)LiquidOralShoppers Drug Mart Inc.1981-12-311997-08-15Canada
Calcium LiquidCalcium gluconate (112 mg) + Calcium glucoheptonate (132 mg)LiquidOralVita Health Products Inc1980-12-312002-07-31Canada
Calcium Magnesium Plus Vitamin D LiquidCalcium gluconate (6 mg) + Ergocalciferol (2 unit) + Inositol (.6 mg) + Magnesium citrate (3 mg)LiquidOralJamp Pharma Corporation2002-04-222003-02-05Canada
Dicalcine Tab No460Calcium gluconate (155 mg) + Calcium lactate (155 mg)TabletOralHerbes Universelles Inc.1976-12-312009-07-15Canada
Liquid CalciumCalcium gluconate (112 mg) + Calcium glucoheptonate (132 mg)LiquidOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1998-08-122000-07-06Canada
Multiple Electrolyte Additive InjCalcium gluconate (20.6 mg) + Magnesium sulfate (19.8 mg) + Potassium chloride (29.8 mg) + Sodium chloride (46.6 mg)LiquidIntravenousInternational Medication Systems, Limited1980-12-311997-08-15Canada
Proception Sperm Nutrient DoucheCalcium gluconate (2.55 %) + Dextrose, unspecified form (71 %) + Potassium chloride (.7 %) + Sodium chloride (25.75 %)DoucheVaginalMilex Products Ltd.1951-12-311997-07-16Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousRemedy Repack2015-10-082016-10-08Us
Calcium GluconateCalcium gluconate monohydrate (98 mg/1mL)Injection, solutionIntravenousAmerican Regent1992-12-01Not applicableUs
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousRemedy Repack2015-06-192017-07-25Us
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousGeneral Injectables & Vaccines2015-06-112017-07-31Us
Calcium GluconateCalcium gluconate monohydrate (98 mg/1mL)Injection, solutionIntravenousAmerican Regent1990-09-30Not applicableUs
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousCardinal Health2000-08-092016-01-31Us
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousA-S Medication Solutions2000-08-09Not applicableUs
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousFresenius Kabi2000-07-12Not applicableUs
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousRemedy Repack2015-03-162017-03-17Us
Calcium GluconateCalcium gluconate (0.465 meq/1mL)Injection, solutionIntravenousGeneral Injectables & Vaccines2010-04-012013-12-01Us
CAS number
Average: 430.372
Monoisotopic: 430.0635463
Chemical Formula
InChI Key
calcium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)



Oral calcium salts are used as dietary supplemental therapy for person who may not get enough calcium in their regular diet. Calcium gluconate is used as a cardioprotective agent in high blood potassium. Calcium gluconate is the antidote for magnesium sulfate toxicity.

Associated Conditions

Calcium Gluconate is the gluconate salt of calcium. An element or mineral necessary for normal nerve, muscle, and cardiac function, calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers.

Mechanism of action

Calcium is essential for the functional integrity of the nervous, muscular, and skeletal systems. It plays a role in normal cardiac function, renal function, respiration, blood coagulation, and cell membrane and capillary permeability. Also, calcium helps to regulate the release and storage of neurotransmitters and hormones, the uptake and binding of amino acids, absorption of vitamin B 12, and gastrin secretion. The major fraction (99%) of calcium is in the skeletal structure primarily as hydroxyapatite, Ca 10(PO 4) 6(OH) 2; small amounts of calcium carbonate and amorphous calcium phosphates are also present. The calcium of bone is in a constant exchange with the calcium of plasma. Since the metabolic functions of calcium are essential for life, when there is a disturbance in the calcium balance because of dietary deficiency or other causes, the stores of calcium in bone may be depleted to fill the body's more acute needs. Therefore, on a chronic basis, normal mineralization of bone depends on adequate amounts of total body calcium.


Approximately one-fifth to one-third of orally administered calcium is absorbed in the small intestine, depending on presence of vitamin D metabolites, pH in lumen, and on dietary factors, such as calcium binding to fiber or phytates. Calcium absorption is increased when a calcium deficiency is present or when a patient is on a low-calcium diet. In patients with achlorhydria or hypochlorhydria, calcium absorption, especially with the carbonate salt, may be reduced.

Volume of distribution

Not available

Protein binding

Moderate, approximately 45% in plasma.


Calcium gluconate does not require hepatic metabolism for the release of Ca++ and is as effective as calcium chloride in treating ionic hypocalcemia in the absence of hepatic function.

Route of elimination

Renal (20%) - The amount excreted in the urine varies with degree of calcium absorption and whether there is excessive bone loss or failure of renal conservation. Fecal (80%) - Consists mainly of nonabsorbed calcium, with only a small amount of endogenous fecal calcium excreted.

Half life
Not Available
Not Available

Infants : LDLo (Intramuscular ) : 10gm/kg ; Effects - Brain and coverings : meningeal changes Infants : TDLo ( Intramuscular ) : 143 mg/kg ; Effects - Dermatits Mouse: LD50 ( intravenous ) : 950mg/kg Mouse : LDLo (Oral ) : 10gm/kg

Affected organisms
Not Available
Not Available
Pharmacogenomic Effects/ADRs
Not Available


Drug Interactions
1alpha-Hydroxyvitamin D5The risk or severity of adverse effects can be increased when Calcium gluconate is combined with 1alpha-Hydroxyvitamin D5.
3-Aza-2,3-Dihydrogeranyl DiphosphateCalcium gluconate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
3,5-diiodothyropropionic acidThe therapeutic efficacy of 3,5-diiodothyropropionic acid can be decreased when used in combination with Calcium gluconate.
AbaloparatideThe therapeutic efficacy of Abaloparatide can be decreased when used in combination with Calcium gluconate.
AcebutololThe therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium gluconate.
AcetyldigitoxinCalcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
AcetyldigoxinCalcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigoxin.
Acetylsalicylic acidThe therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Calcium gluconate.
AgmatineThe therapeutic efficacy of Agmatine can be decreased when used in combination with Calcium gluconate.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium gluconate.
Food Interactions
Not Available


General References
  1. Martin TJ, Kang Y, Robertson KM, Virji MA, Marquez JM: Ionization and hemodynamic effects of calcium chloride and calcium gluconate in the absence of hepatic function. Anesthesiology. 1990 Jul;73(1):62-5. [PubMed:2360741]
  2. Wikipedia [Link]
  3. DRUGS.COM [Link]
  4. Pubchem [Link]
  5. ChemIDplus [Link]
  6. DRUGS.COM [Link]
External Links
KEGG Compound
PubChem Compound
PubChem Substance
ATC Codes
A12AA03 — Calcium gluconateD11AX03 — Calcium gluconate
AHFS Codes
  • 88:29.00* — Minerals
  • 40:12.00 — Replacement Preparations

Clinical Trials

Clinical Trials
1CompletedPreventionPaclitaxel-induced Neuropathy1
2CompletedSupportive CareArthralgia/joint pain / Musculoskeletal Complications / Pain NOS / Recurrent Breast Cancer / Stage I Breast Carcinoma / Stage II Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer1
3Active Not RecruitingSupportive CareOsteoporosis / Prostate Cancer1
3CompletedDiagnosticCancer, Breast / Osteoporosis1
3CompletedPreventionOvarian Hyperstimulation1
3CompletedSupportive CareChemotherapeutic Agent Toxicity / Colorectal Cancers / Neurologic toxicity / Neuropathy1
3CompletedSupportive CareColorectal Cancers / Neurologic toxicity1
3TerminatedSupportive CareNeuropathy / Pain NOS / Recurrent Breast Carcinoma / Stage IV Breast Cancer1
Not AvailableCompletedScreeningConotruncal Cardiac Defects / Heart Defects,Congenital / Parathyroid deficiency / Pulmonary Atresia / Pulmonary Valve Stenosis / Tetralogy Of Fallot1


Not Available
Not Available
Dosage forms
Injection, solutionIntravenous0.465 meq/1mL
Injection, solutionIntravenous20 mg/1mL
Injection, solutionIntravenous94 mg/1mL
Injection, solutionIntravenous98 mg/1mL
LiquidIntravenous100 mg
SolutionIntravenous100 mg
SolutionIntramuscular; Intravenous100 mg
SolutionIntravenous.465 meq
SolutionIntravenous94 mg
TabletOral600 mg
TabletOral648 mg
TabletOral650 mg
LiquidIntravenous10 %
Not Available
Patent NumberPediatric ExtensionApprovedExpires (estimated)


Not Available
Experimental Properties
Not Available
Predicted Properties
Water Solubility44.2 mg/mLALOGPS
pKa (Strongest Acidic)3.39ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area141.28 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity49.11 m3·mol-1ChemAxon
Polarizability16.62 Å3ChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available


Mass Spec (NIST)
Not Available
Not Available


This compound belongs to the class of organic compounds known as sugar acids and derivatives. These are compounds containing a saccharide unit which bears a carboxylic acid group.
Organic compounds
Super Class
Organic oxygen compounds
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
Sugar acids and derivatives
Alternative Parents
Medium-chain hydroxy acids and derivatives / Medium-chain fatty acids / Beta hydroxy acids and derivatives / Hydroxy fatty acids / Monosaccharides / Secondary alcohols / Carboxylic acid salts / Polyols / Carboxylic acids / Organic calcium salts
show 6 more
Gluconic_acid / Medium-chain hydroxy acid / Medium-chain fatty acid / Beta-hydroxy acid / Hydroxy fatty acid / Hydroxy acid / Fatty acyl / Fatty acid / Monosaccharide / Carboxylic acid salt
show 14 more
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on December 03, 2015 09:51 / Updated on March 18, 2019 22:40