Silicon dioxide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Silicon dioxide
Accession Number
DB11132
Type
Small Molecule
Groups
Approved
Description

Silicon dioxide, or silica, is an oxide of silicon with the chemical formula SiO2. It is found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite as transparent and tasteless crystals. Inhalation of fine crystals is toxic to humans leading to respiratory toxicity. In powdered food products and pharmaceutical tablets, silicon dioxide is added as a flow agent to absorb water. Colloidal silica is also used as a wine, beer, and juice fining agent or stabilizer.

Structure
Thumb
Synonyms
  • Colloidal silica
  • Colloidal silicon dioxide
  • Diatomaceous earth
  • Diatomaceous silica
  • Diatomite
  • Infusorial earth
  • Kieselsäureanhydrid
  • Silica
  • Silica gel
  • Silica, colloidal
  • Siliceous earth
  • Siliceous earth, purified
  • Silicon dioxide (amorphous)
  • Silicon dioxide, colloidal
  • Silicon dioxide, fumed
  • Silicon oxide
  • Siliziumdioxid
External IDs
E-551 / INS NO.551 / INS-551 / U 333
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
2080 Dentistry Night FreshPaste, dentifrice15 g/100gDentalAekyung Industrial Co., Ltd.2017-02-03Not applicableUs
2080 Dentistry Night RepairPaste, dentifrice15 g/100gDentalAekyung Industrial Co., Ltd.2017-02-03Not applicableUs
28tak Doux ToothPaste, dentifrice4.8 g/60gOralElmeditec Co.,Ltd2018-07-01Not applicableUs
Evertox Special Bath PreparationsPowder20 g/100gTopicalKmtr Co., Ltd.2015-01-11Not applicableUs
LubasPaste, dentifrice17 g/100gDentalLubasbio Co., Ltd2013-11-23Not applicableUs
Olea OlidentalPaste170 mg/1gOralAju Pharm Co., Ltd.2017-01-17Not applicableUs
Oprecare 12Gel1.71 g/60gDentalO'precare2017-10-12Not applicableUs
Oprecare 24Gel1.425 g/50gDentalO'precare2017-10-12Not applicableUs
Silica GelGel80 mgOralAbundance Marketing Ltd.1998-01-052004-06-30Canada
Sonatural All Kill Blackhead ClearStick0.88 g/11gTopicalSonatural Global Co.,ltd2017-10-01Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
28tak Clair ToothSilicon dioxide (4.8 g/60g) + Sodium fluorophosphate (0.13 g/60g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUs
Alegria NeoSilicon dioxide (2.80 g/20g) + Allantoin (0.008 g/20g)Paste, dentifriceTopicalSeowangmo Corporation2017-10-01Not applicableUs
BAMBOO SALT Eunganggo Jook YeomSilicon dioxide (20 g/100g) + Aminocaproic Acid (0.05 g/100g) + Curcuma xanthorrhiza oil (0.025 g/100g) + Glycyrrhizinate dipotassium (0.04 g/100g) + Sea salt (3 g/100g) + Sodium fluoride (0.22 g/100g) + Ursodeoxycholic acid (0.02 g/100g)PasteDentalLg Household & Health Care Ltd.2011-03-15Not applicableUs
BAMBOO SALT Eunganggo Jook Yeom ToothpasteSilicon dioxide (20 g/100g) + Aminocaproic Acid (0.05 g/100g) + Curcuma xanthorrhiza oil (0.025 g/100g) + Glycyrrhizinate dipotassium (0.04 g/100g) + Sea salt (3 g/100g) + Sodium fluoride (0.22 g/100g) + Ursodeoxycholic acid (0.02 g/100g)PasteDentalLg Household & Health Care Ltd.2010-05-25Not applicableUs
Calcium and Magnesium 1:1 Plus TabletsSilicon dioxide (5 mg) + Calcium (250 mg) + Cholecalciferol (100 unit) + Magnesium (250 mg) + Manganese (1 mg) + Potassium (20 mg) + Zinc (5 mg)TabletOralAlbi Naturals1998-02-202009-07-15Canada
Chunzam Silk Amino Acid ToothSilicon dioxide (4 g/100g) + Sodium fluorophosphate (0.33 g/100g) + alpha-Tocopherol acetate (0.1 g/100g)Paste, dentifriceDentalChunzam Bio Co Ltd2016-11-11Not applicableUs
Colgate Total Advanced Health Daily RepairSilicon dioxide (5 %) + Sodium fluoride (0.243 %) + Triclosan (0.3 %)Paste, dentifriceDentalColgate Palmolive2016-01-15Not applicableCanada
Colgate Total Advanced Health SensitiveSilicon dioxide (5 %) + Sodium fluoride (0.243 %) + Triclosan (0.3 %)Paste, dentifriceDentalColgate Palmolive2012-07-23Not applicableCanada
Colgate Total Clean MintSilicon dioxide (50 mg/1g) + Sodium fluoride (2.4 mg/1g) + Triclosan (3 mg/1g)Paste, dentifriceDentalColgate Palmolive2010-11-30Not applicableUs
Colgate Total Gum DefenseSilicon dioxide (50 mg/1g) + Sodium fluoride (2.4 mg/1g) + Triclosan (3 mg/1g)Paste, dentifriceDentalColgate-Palmolive2011-06-252013-12-10Us
Categories
UNII
ETJ7Z6XBU4
CAS number
7631-86-9
Weight
Average: 60.0843
Monoisotopic: 59.966755777
Chemical Formula
O2Si
InChI Key
VYPSYNLAJGMNEJ-UHFFFAOYSA-N
InChI
InChI=1S/O2Si/c1-3-2
IUPAC Name
silanedione
SMILES
O=[Si]=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UMacrophage receptor MARCONot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
Human Metabolome Database
HMDB0035659
PubChem Compound
22644374
PubChem Substance
347827911
ChemSpider
22683
ChEBI
30563
ChEMBL
CHEMBL3188292
Wikipedia
Silicon_dioxide
AHFS Codes
  • 88:29.00* — Minerals

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedNot AvailableAcid Reflux Disease / Gastro-esophageal Reflux Disease (GERD) / Heartburn / Regurgitation1
2CompletedTreatmentDepression1
2CompletedTreatmentDiarrhoea;Acute1
2CompletedTreatmentNegative Middle Ear Pressure / Otitis Media (OM)1
2, 3CompletedNot AvailableLesion of Stomach1
4CompletedDiagnosticGastric Mucosal Lesion1
4CompletedDiagnosticStomach Neoplasms1
4CompletedTreatmentColonoscopy1
4CompletedTreatmentIleus / Postoperative paralytic ileus1
4CompletedTreatmentInfantile Colics1
4TerminatedTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
Not AvailableRecruitingScreeningColorectal Cancers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Paste, dentifriceDental15 g/100g
Paste, dentifriceOral
Paste, dentifriceOral4.8 g/60g
Paste, dentifriceTopical
PasteDental
Paste, dentifriceDental
PowderTopical20 g/100g
PasteTopical
TabletOral
Paste, dentifriceDental17 g/100g
PowderTopical
Tablet, chewableOral
PasteOral
PasteOral170 mg/1g
GelDental1.71 g/60g
GelDental1.425 g/50g
Kit
LiquidOral
EmulsionOral
LiquidTopical
GelOral80 mg
Solution / dropsOral
StickTopical0.88 g/11g
PowderTopical51 kg/100kg
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.66ChemAxon
pKa (Strongest Basic)-8.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area34.14 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity2.89 m3·mol-1ChemAxon
Polarizability3.28 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
Specific Function
Scavenger receptor activity
Gene Name
MARCO
Uniprot ID
Q9UEW3
Uniprot Name
Macrophage receptor MARCO
Molecular Weight
52657.905 Da
References
  1. Thakur SA, Hamilton R Jr, Pikkarainen T, Holian A: Differential binding of inorganic particles to MARCO. Toxicol Sci. 2009 Jan;107(1):238-46. doi: 10.1093/toxsci/kfn210. Epub 2008 Oct 4. [PubMed:18836211]

Drug created on December 03, 2015 09:51 / Updated on November 17, 2018 07:25