Gastro-esophageal Reflux Disease (GERD)

Also known as: Esophageal Reflux / Gastroesophageal Reflux Disease / Gastrooesophageal reflux disease / Gastro-Oesophageal Reflux Disease / Gastro-esophageal Reflux Disease / Gastro-esophageal Reflux Diseases / GERD Gastroesophageal Reflux Disease / GERD (Gastroesophageal Reflux Disease) / GERD / GERD - Gastro-Esophageal Reflux Disease / Gastroesophageal Reflux Disease (GERD) / Oesophageal reflux / Esophagitis / Gastrooesophageal reflux / Gastroesophageal reflux / Esophageal reflux NOS

DrugDrug NameDrug Description
DB00501CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
DB00736EsomeprazoleA proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion.
DB00927FamotidineA histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome.
DB00448LansoprazoleA proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
DB00585NizatidineAn H2 receptor antagonist used to treat GERD and a variety of ulcers.
DB00338OmeprazoleA proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection.
DB00213PantoprazoleA proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid.
DB01129RabeprazoleA proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
DB00863RanitidineA histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis.
DB00364SucralfateA gastro-duodenal protective agent used in the treatment of gastric and duodenal ulcers and to prevent duodenal ulcer recurrence.
DrugDrug NameTargetType
DB00501CimetidineHistamine H2 receptortarget
DB00501CimetidineCytochrome P450 1A2enzyme
DB00501CimetidineCytochrome P450 2D6enzyme
DB00501CimetidineCytochrome P450 2C19enzyme
DB00501CimetidineCytochrome P450 3A4enzyme
DB00501CimetidineCytochrome P450 3A5enzyme
DB00501CimetidineP-glycoprotein 1transporter
DB00501CimetidineSolute carrier family 22 member 2transporter
DB00501CimetidineSolute carrier family 22 member 1transporter
DB00501CimetidineSolute carrier family 22 member 3transporter
DB00501CimetidineSolute carrier family 22 member 5transporter
DB00501CimetidineSolute carrier family 22 member 6transporter
DB00501CimetidineSolute carrier family 22 member 8transporter
DB00501CimetidineMultidrug and toxin extrusion protein 1transporter
DB00501CimetidineSolute carrier family 22 member 4transporter
DB00501CimetidineSolute carrier family 22 member 11transporter
DB00501CimetidineSolute carrier family 22 member 7transporter
DB00501CimetidineCytochrome P450 11B1, mitochondrialenzyme
DB00501CimetidineCytochrome P450 2C8enzyme
DB00501CimetidineCytochrome P450 2C9enzyme
DB00501CimetidineCytochrome P450 2E1enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00501CimetidineBile salt export pumptransporter
DB00501CimetidineMultidrug and toxin extrusion protein 2transporter
DB00736EsomeprazolePotassium-transporting ATPase alpha chain 1target
DB00736EsomeprazoleCytochrome P450 2C19enzyme
DB00736EsomeprazoleCytochrome P450 3A4enzyme
DB00736EsomeprazoleN(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
DB00736EsomeprazoleP-glycoprotein 1transporter
DB00736EsomeprazoleSolute carrier family 22 member 8transporter
DB00927FamotidineHistamine H2 receptortarget
DB00927FamotidineSolute carrier family 22 member 2transporter
DB00927FamotidineSolute carrier family 22 member 8transporter
DB00448LansoprazolePotassium-transporting ATPase alpha chain 1target
DB00448LansoprazoleCytochrome P450 2C19enzyme
DB00448LansoprazoleCytochrome P450 2C9enzyme
DB00448LansoprazoleCytochrome P450 3A4enzyme
DB00448LansoprazoleP-glycoprotein 1transporter
DB00448LansoprazoleATP-binding cassette sub-family G member 2transporter
DB00448LansoprazoleCytochrome P450 1A1enzyme
DB00448LansoprazoleCytochrome P450 1B1enzyme
DB00448LansoprazoleCytochrome P450 2C18enzyme
DB00448LansoprazoleCytochrome P450 2C8enzyme
DB00448LansoprazoleCytochrome P450 2D6enzyme
DB00448LansoprazoleMicrotubule-associated protein tautarget
DB00448LansoprazoleSolute carrier family 22 member 8transporter
DB00448LansoprazoleSolute carrier family 22 member 1transporter
DB00448LansoprazoleSolute carrier family 22 member 2transporter
DB00448LansoprazoleSolute carrier family 22 member 3transporter
DB00585NizatidineHistamine H2 receptortarget
DB00585NizatidineP-glycoprotein 1transporter
DB00585NizatidineCholinesteraseenzyme
DB00338OmeprazolePotassium-transporting ATPase alpha chain 1target
DB00338OmeprazoleCytochrome P450 2C19enzyme
DB00338OmeprazoleCytochrome P450 3A4enzyme
DB00338OmeprazoleCytochrome P450 2C9enzyme
DB00338OmeprazoleCytochrome P450 1A2enzyme
DB00338OmeprazoleCanalicular multispecific organic anion transporter 2transporter
DB00338OmeprazoleP-glycoprotein 1transporter
DB00338OmeprazoleATP-binding cassette sub-family G member 2transporter
DB00338OmeprazoleCytochrome P450 1A1enzyme
DB00338OmeprazoleCytochrome P450 1B1enzyme
DB00338OmeprazoleCytochrome P450 2C18enzyme
DB00338OmeprazoleCytochrome P450 2C8enzyme
DB00338OmeprazoleCytochrome P450 2D6enzyme
DB00338OmeprazoleAryl hydrocarbon receptortarget
DB00213PantoprazolePotassium-transporting ATPase alpha chain 1target
DB00213PantoprazoleCytochrome P450 2C19enzyme
DB00213PantoprazoleCytochrome P450 3A4enzyme
DB00213PantoprazoleP-glycoprotein 1transporter
DB00213PantoprazoleATP-binding cassette sub-family G member 2transporter
DB00213PantoprazoleSolute carrier family 22 member 8transporter
DB00213PantoprazoleN(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
DB01129RabeprazolePotassium-transporting ATPase alpha chain 1target
DB01129RabeprazoleCytochrome P450 3A4enzyme
DB01129RabeprazoleCytochrome P450 2C19enzyme
DB01129RabeprazoleATP-binding cassette sub-family G member 2transporter
DB01129RabeprazoleCytochrome P450 1A1enzyme
DB01129RabeprazoleCytochrome P450 1A2enzyme
DB01129RabeprazoleCytochrome P450 2C9enzyme
DB01129RabeprazoleCytochrome P450 2D6enzyme
DB01129RabeprazoleCytochrome P450 2C8enzyme
DB00863RanitidineHistamine H2 receptortarget
DB00863RanitidineCytochrome P450 1A2enzyme
DB00863RanitidineCytochrome P450 2D6enzyme
DB00863RanitidineSolute carrier family 22 member 1transporter
DB00863RanitidineP-glycoprotein 1transporter
DB00863RanitidineSolute carrier family 22 member 8transporter
DB00863RanitidineCytochrome P450 3A4enzyme
DB00863RanitidineAcetylcholinesterasetarget
DB00863RanitidineSolute carrier family 22 member 2transporter
DB00863RanitidineCholinesterasetarget
DB00863RanitidineCholinesteraseenzyme
DB00364SucralfateFibrinogentarget
DB00364SucralfatePepsin A-5target
DB00364SucralfatePro-epidermal growth factortarget
DB00364SucralfateFibroblast growth factor 2target
DrugDrug NamePhaseStatusCount
DB00693Fluorescein0Terminated1
DB01123Proflavine0Terminated1
DB06723Aluminum hydroxide1Completed1
DB06723Aluminum hydroxide1Recruiting1
DB00594Amiloride1Completed1
DB05351Dexlansoprazole1Completed2
DB00736Esomeprazole1Completed4
DB00736Esomeprazole1Not Yet Recruiting1
DB00448Lansoprazole1Completed2
DB12884Lavoltidine1Completed1
DB11920Lesogaberan1Completed2
DB09481Magnesium carbonate1Completed1
DB09481Magnesium carbonate1Recruiting1
DB13004Mavoglurant1Completed1
DB15325ONO-85391Completed1
DB00213Pantoprazole1Completed2
DB04216Quercetin1Completed1
DB01129Rabeprazole1Completed3
DB05351Dexlansoprazole1 / 2Withdrawn1
DB00736Esomeprazole1 / 2Unknown Status1
DB00448Lansoprazole1 / 2Unknown Status1
DB01065Melatonin1 / 2Unknown Status1
DB00338Omeprazole1 / 2Unknown Status1
DB05269Activated charcoal2Terminated1
DB09278Activated charcoal2Terminated1
DB06723Aluminum hydroxide2Completed1
DB12031Ammonio methacrylate copolymer type A2Completed1
DB08891Arbaclofen2Completed1
DB05031Arbaclofen Placarbil2Completed1
DB08892Arbaclofen Placarbil2Completed2
DB01373Calcium2Completed1
DB14531Carbonate ion2Completed1
DB05351Dexlansoprazole2Completed2
DB11074Dimethicone2Completed1
DB00736Esomeprazole2Completed3
DB00736Esomeprazole2Not Yet Recruiting1
DB00736Esomeprazole2Terminated1
DB00736Esomeprazole2Unknown Status1
DB11964Ilaprazole2Unknown Status1
DB12884Lavoltidine2Completed1
DB11920Lesogaberan2Active Not Recruiting1
DB11920Lesogaberan2Completed4
DB09104Magnesium hydroxide2Completed1
DB14158Microcrystalline cellulose2Terminated1
DB00338Omeprazole2Completed1
DB12402Pumosetrag2Completed1
DB01129Rabeprazole2Completed3
DB00863Ranitidine2Completed1
DB11132Silicon dioxide2Completed1
DB13518Alginic acid2 / 3Completed1
DB06723Aluminum hydroxide2 / 3Completed1
DB01222Budesonide2 / 3Completed1
DB00736Esomeprazole2 / 3Completed1
DB00736Esomeprazole2 / 3Unknown Status1
DB09481Magnesium carbonate2 / 3Completed1
DB00540Nortriptyline2 / 3Completed1
DB00213Pantoprazole2 / 3Completed1
DB01129Rabeprazole2 / 3Completed1
DB13518Alginic acid3Completed4
DB13518Alginic acid3Recruiting1
DB13518Alginic acid3Terminated1
DB06723Aluminum hydroxide3Completed3
DB06723Aluminum hydroxide3Terminated1
DB00181Baclofen3Completed1
DB01151Desipramine3Completed1
DB05351Dexlansoprazole3Completed5
DB01184Domperidone3Recruiting2
DB01184Domperidone3Withdrawn1
DB00736Esomeprazole3Completed11
DB00736Esomeprazole3Unknown Status1
DB00736Esomeprazole3Withdrawn1
DB11964Ilaprazole3Completed2
DB00458Imipramine3Completed1
DB00448Lansoprazole3Completed2
DB00448Lansoprazole3Unknown Status1
DB00281Lidocaine3Completed1
DB11845Lucitanib3Completed1
DB09481Magnesium carbonate3Completed3
DB09481Magnesium carbonate3Terminated1
DB01065Melatonin3Withdrawn1
DB00585Nizatidine3Completed1
DB00540Nortriptyline3Completed1
DB00338Omeprazole3Completed2
DB00338Omeprazole3Recruiting1
DB00338Omeprazole3Unknown Status1
DB00213Pantoprazole3Completed5
DB00213Pantoprazole3Unknown Status2
DB00213Pantoprazole3Withdrawn1
DB01129Rabeprazole3Completed8
DB01129Rabeprazole3Unknown Status1
DB01129Rabeprazole3Withdrawn1
DB00980Ramelteon3Unknown Status1
DB00863Ranitidine3Completed2
DB01390Sodium bicarbonate3Withdrawn1
DB09372Tannic acid3Completed1
DB01079Tegaserod3Completed2
DB00945Acetylsalicylic acid4Not Yet Recruiting1
DB13518Alginic acid4Unknown Status1
DB06723Aluminum hydroxide4Completed1
DB01060Amoxicillin4Not Yet Recruiting1
DB00181Baclofen4Withdrawn1
DB11695Carnosine4Recruiting1
DB00215Citalopram4Recruiting1
DB01211Clarithromycin4Not Yet Recruiting1
DB05351Dexlansoprazole4Completed2
DB05351Dexlansoprazole4Enrolling by Invitation1
DB13762Dexrabeprazole4Completed1
DB11074Dimethicone4Completed1
DB01184Domperidone4Completed2
DB01184Domperidone4Not Yet Recruiting1
DB01184Domperidone4Unknown Status1
DB00736Esomeprazole4Completed21
DB00736Esomeprazole4Unknown Status1
DB12545Indobufen4Not Yet Recruiting1
DB00448Lansoprazole4Completed3
DB00448Lansoprazole4Enrolling by Invitation1
DB00448Lansoprazole4Not Yet Recruiting1
DB00448Lansoprazole4Terminated1
DB00448Lansoprazole4Unknown Status1
DB09104Magnesium hydroxide4Completed1
DB09281Magnesium trisilicate4Completed1
DB00540Nortriptyline4Completed1
DB00338Omeprazole4Completed5
DB00338Omeprazole4Recruiting2
DB00338Omeprazole4Unknown Status1
DB00213Pantoprazole4Completed4
DB00213Pantoprazole4Recruiting1
DB00213Pantoprazole4Terminated1
DB11097Plantago seed4Completed1
DB06480Prucalopride4Recruiting1
DB01129Rabeprazole4Completed5
DB01129Rabeprazole4Not Yet Recruiting1
DB11132Silicon dioxide4Completed1
DB11739Vonoprazan4Recruiting1
DB01593Zinc4Recruiting1
DB00181BaclofenNot AvailableCompleted1
DB00501CimetidineNot AvailableCompleted1
DB00215CitalopramNot AvailableNot Yet Recruiting1
DB05351DexlansoprazoleNot AvailableWithdrawn1
DB01184DomperidoneNot AvailableAvailable1
DB01184DomperidoneNot AvailableNot Yet Recruiting1
DB01184DomperidoneNot AvailableTerminated1
DB05265EcabetNot AvailableCompleted1
DB00736EsomeprazoleNot AvailableCompleted5
DB00736EsomeprazoleNot AvailableNot Yet Recruiting2
DB00927FamotidineNot AvailableCompleted1
DB00875FlupentixolNot AvailableNot Yet Recruiting1
DB05381HistamineNot AvailableCompleted1
DB12770LafutidineNot AvailableCompleted1
DB00448LansoprazoleNot AvailableCompleted2
DB00448LansoprazoleNot AvailableNot Yet Recruiting1
DB00448LansoprazoleNot AvailableTerminated1
DB00448LansoprazoleNot AvailableWithdrawn1
DB00281LidocaineNot AvailableRecruiting1
DB13384MelitracenNot AvailableNot Yet Recruiting1
DB11675MosaprideNot AvailableNot Yet Recruiting2
DB13760NiperotidineNot AvailableCompleted1
DB00585NizatidineNot AvailableCompleted1
DB00338OmeprazoleNot AvailableCompleted5
DB00338OmeprazoleNot AvailableNot Yet Recruiting1
DB00338OmeprazoleNot AvailableWithdrawn1
DB00213PantoprazoleNot AvailableCompleted5
DB00213PantoprazoleNot AvailableNot Yet Recruiting1
DB01129RabeprazoleNot AvailableActive Not Recruiting1
DB01129RabeprazoleNot AvailableCompleted2
DB01129RabeprazoleNot AvailableNot Yet Recruiting1
DB01129RabeprazoleNot AvailableUnknown Status1
DB00863RanitidineNot AvailableCompleted1
DB08806Roxatidine acetateNot AvailableCompleted1
DB09512SimethiconeNot AvailableCompleted1
DB00364SucralfateNot AvailableWithdrawn1
DB01586Ursodeoxycholic acidNot AvailableCompleted1