5-hydroxytryptamine receptor 1B

Details

Name
5-hydroxytryptamine receptor 1B
Synonyms
  • 5-HT-1B
  • 5-HT-1D-beta
  • HTR1DB
  • S12
  • Serotonin 1D beta receptor
  • Serotonin receptor 1B
Gene Name
HTR1B
Organism
Humans
Amino acid sequence
>lcl|BSEQ0019014|5-hydroxytryptamine receptor 1B
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT
LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV
VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI
SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL
KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE
KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL
NSLINPIIYTMSNEDFKQAFHKLIRFKCTS
Number of residues
390
Molecular Weight
43567.535
Theoretical pI
8.82
GO Classification
Functions
drug binding / serotonin binding / serotonin receptor activity
Processes
adenylate cyclase-inhibiting serotonin receptor signaling pathway / bone remodeling / cellular response to alkaloid / cellular response to drug / cellular response to temperature stimulus / drinking behavior / G-protein coupled receptor internalization / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / negative regulation of cAMP biosynthetic process / negative regulation of serotonin secretion / negative regulation of synaptic transmission, GABAergic / negative regulation of synaptic transmission, glutamatergic / protein kinase C-activating G-protein coupled receptor signaling pathway / regulation of behavior / regulation of dopamine secretion / response to cocaine / response to ethanol / response to mineralocorticoid / synaptic transmission / vasoconstriction
Components
cytoplasm / integral component of plasma membrane / plasma membrane
General Function
Serotonin receptor activity
Specific Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Pfam Domain Function
Transmembrane Regions
50-75 85-110 124-145 166-187 206-228 316-336 350-371
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0019015|5-hydroxytryptamine receptor 1B (HTR1B)
ATGGAGGAACCGGGTGCTCAGTGCGCTCCACCGCCGCCCGCGGGCTCCGAGACCTGGGTT
CCTCAAGCCAACTTATCCTCTGCTCCCTCCCAAAACTGCAGCGCCAAGGACTACATTTAC
CAGGACTCCATCTCCCTACCCTGGAAAGTACTGCTGGTTATGCTATTGGCGCTCATCACC
TTGGCCACCACGCTCTCCAATGCCTTTGTGATTGCCACAGTGTACCGGACCCGGAAACTG
CACACCCCGGCTAACTACCTGATCGCCTCTCTGGCGGTCACCGACCTGCTTGTGTCCATC
CTGGTGATGCCCATCAGCACCATGTACACTGTCACCGGCCGCTGGACACTGGGCCAGGTG
GTCTGTGACTTCTGGCTGTCGTCGGACATCACTTGTTGCACTGCCTCCATCCTGCACCTC
TGTGTCATCGCCCTGGACCGCTACTGGGCCATCACGGACGCCGTGGAGTACTCAGCTAAA
AGGACTCCCAAGAGGGCGGCGGTCATGATCGCGCTGGTGTGGGTCTTCTCCATCTCTATC
TCGCTGCCGCCCTTCTTCTGGCGTCAGGCTAAGGCCGAAGAGGAGGTGTCGGAATGCGTG
GTGAACACCGACCACATCCTCTACACGGTCTACTCCACGGTGGGTGCTTTCTACTTCCCC
ACCCTGCTCCTCATCGCCCTCTATGGCCGCATCTACGTAGAAGCCCGCTCCCGGATTTTG
AAACAGACGCCCAACAGGACCGGCAAGCGCTTGACCCGAGCCCAGCTGATAACCGACTCC
CCCGGGTCCACGTCCTCGGTCACCTCTATTAACTCGCGGGTTCCCGACGTGCCCAGCGAA
TCCGGATCTCCTGTGTATGTGAACCAAGTCAAAGTGCGAGTCTCCGACGCCCTGCTGGAA
AAGAAGAAACTCATGGCCGCTAGGGAGCGCAAAGCCACCAAGACCCTAGGGATCATTTTG
GGAGCCTTTATTGTGTGTTGGCTACCCTTCTTCATCATCTCCCTAGTGATGCCTATCTGC
AAAGATGCCTGCTGGTTCCACCTAGCCATCTTTGACTTCTTCACATGGCTGGGCTATCTC
AACTCCCTCATCAACCCCATAATCTATACCATGTCCAATGAGGACTTTAAACAAGCATTC
CATAAACTGATACGTTTTAAGTGCACAAGTTGA
Chromosome Location
6
Locus
6q13
External Identifiers
ResourceLink
UniProtKB IDP28222
UniProtKB Entry Name5HT1B_HUMAN
GenBank Protein ID219679
GenBank Gene IDD10995
GenAtlas IDHTR1B
HGNC IDHGNC:5287
General References
  1. Hamblin MW, Metcalf MA, McGuffin RW, Karpells S: Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity. Biochem Biophys Res Commun. 1992 Apr 30;184(2):752-9. [PubMed:1315531]
  2. Mochizuki D, Yuyama Y, Tsujita R, Komaki H, Sagai H: Cloning and expression of the human 5-HT1B-type receptor gene. Biochem Biophys Res Commun. 1992 Jun 15;185(2):517-23. [PubMed:1610347]
  3. Jin H, Oksenberg D, Ashkenazi A, Peroutka SJ, Duncan AM, Rozmahel R, Yang Y, Mengod G, Palacios JM, O'Dowd BF: Characterization of the human 5-hydroxytryptamine1B receptor. J Biol Chem. 1992 Mar 25;267(9):5735-8. [PubMed:1348246]
  4. Levy FO, Gudermann T, Perez-Reyes E, Birnbaumer M, Kaumann AJ, Birnbaumer L: Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. J Biol Chem. 1992 Apr 15;267(11):7553-62. [PubMed:1559993]
  5. Weinshank RL, Zgombick JM, Macchi MJ, Branchek TA, Hartig PR: Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. [PubMed:1565658]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00216Eletriptanapproved, investigationalyesagonistDetails
DB00315Zolmitriptanapproved, investigationalyesagonistDetails
DB00952Naratriptanapproved, investigationalyesagonistDetails
DB00953RizatriptanapprovedyesagonistDetails
DB00998Frovatriptanapproved, investigationalyesagonistDetails
DB00320Dihydroergotamineapproved, investigationalyesagonistDetails
DB00669Sumatriptanapproved, investigationalyesagonistDetails
DB00696ErgotamineapprovedyesagonistDetails
DB00918Almotriptanapproved, investigationalunknownagonistDetails
DB00960Pindololapproved, investigationalunknownother/unknownDetails
DB04884DapoxetineinvestigationalunknownDetails
DB00571Propranololapproved, investigationalunknownother/unknownDetails
DB06096NXN-188investigationalunknownDetails
DB06216AsenapineapprovedunknownantagonistDetails
DB01186Pergolideapproved, investigational, vet_approved, withdrawnunknownagonistDetails
DB01200Bromocriptineapproved, investigationalunknownagonistDetails
DB00589Lisurideapproved, investigationalunknownagonistDetails
DB00248CabergolineapprovedunknownagonistDetails
DB00714Apomorphineapproved, investigationalunknownagonistDetails
DB00246ZiprasidoneapprovedunknownantagonistDetails
DB00363ClozapineapprovedunknownantagonistDetails
DB01238Aripiprazoleapproved, investigationalunknownantagonistDetails
DB01224Quetiapineapprovedunknownother/unknownDetails
DB01392Yohimbineapproved, investigational, vet_approvedunknownantagonistDetails
DB08807BopindololexperimentalunknownDetails
DB00904Ondansetronapprovedunknownother/unknownDetails
DB00408LoxapineapprovedunknownbinderDetails
DB00543AmoxapineapprovedunknownantagonistDetails
DB00247MethysergideapprovedunknownbinderDetails
DB00321AmitriptylineapprovedunknownbinderDetails
DB01359Penbutololapproved, investigationalunknownantagonistDetails
DB09068Vortioxetineapproved, investigationalyespartial agonistDetails
DB06153PizotifenapprovedunknownantagonistDetails
DB14185Aripiprazole lauroxilapproved, investigationalunknownDetails
DB13025TiaprideinvestigationalyesantagonistDetails
DB09304SetiptilineexperimentalunknownantagonistDetails
DB13345Dihydroergocristineapproved, experimentalyesantagonistDetails
DB01049Ergoloid mesylateapprovedyesantagonistagonistDetails
DB11273DihydroergocornineapprovedyesantagonistagonistDetails
DB12141Gilteritinibapproved, investigationalnoinhibitorDetails
DB01221Ketamineapproved, vet_approvedunknownantagonistDetails
DB00334Olanzapineapproved, investigationalunknowninhibitorDetails