Hemoglobin subunit alpha

Details

Name
Hemoglobin subunit alpha
Synonyms
  • Alpha-globin
  • Hemoglobin alpha chain
Gene Name
HBA1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0036956|Hemoglobin subunit alpha
MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHG
KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP
AVHASLDKFLASVSTVLTSKYR
Number of residues
142
Molecular Weight
15257.405
Theoretical pI
9.09
GO Classification
Functions
heme binding / iron ion binding / oxygen binding / oxygen transporter activity
Processes
bicarbonate transport / hydrogen peroxide catabolic process / oxidation-reduction process / oxygen transport / positive regulation of cell death / protein heterooligomerization / receptor-mediated endocytosis / response to hydrogen peroxide / small molecule metabolic process
Components
blood microparticle / cytosol / cytosolic small ribosomal subunit / endocytic vesicle lumen / extracellular exosome / extracellular region / haptoglobin-hemoglobin complex / hemoglobin complex / membrane
General Function
Oxygen transporter activity
Specific Function
Involved in oxygen transport from the lung to the various peripheral tissues.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0010173|Hemoglobin subunit alpha (HBA1)
ATGGTGCTGTCTCCTGCCGACAAGACCAACGTCAAGGCCGCCTGGGGTAAGGTCGGCGCG
CACGCTGGCGAGTATGGTGCGGAGGCCCTGGAGAGGATGTTCCTGTCCTTCCCCACCACC
AAGACCTACTTCCCGCACTTCGACCTGAGCCACGGCTCTGCCCAGGTTAAGGGCCACGGC
AAGAAGGTGGCCGACGCGCTGACCAACGCCGTGGCGCACGTGGACGACATGCCCAACGCG
CTGTCCGCCCTGAGCGACCTGCACGCGCACAAGCTTCGGGTGGACCCGGTCAACTTCAAG
CTCCTAAGCCACTGCCTGCTGGTGACCCTGGCCGCCCACCTCCCCGCCGAGTTCACCCCT
GCGGTGCACGCCTCCCTGGACAAGTTCCTGGCTTCTGTGAGCACCGTGCTGACCTCCAAA
TACCGTTAA
Chromosome Location
16
Locus
16p13.3
External Identifiers
ResourceLink
UniProtKB IDP69905
UniProtKB Entry NameHBA_HUMAN
GenBank Protein ID386764
GenBank Gene IDJ00153
GenAtlas IDHBA1
HGNC IDHGNC:4823
General References
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  12. HILL RJ, KONIGSBERG W: The structure of human hemoglobin. IV. The chymotryptic digestion of the alpha chain of human hemoglobin. J Biol Chem. 1962 Oct;237:3151-6. [PubMed:13954546]
  13. SCHROEDER WA, SHELTON JR, SHELTON JB, CORMICK J: THE AMINO ACID SEQUENCE OF THE ALPHA CHAIN OF HUMAN FETAL HEMOGLOBIN. Biochemistry. 1963 Nov-Dec;2:1353-7. [PubMed:14093912]
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  15. Webber BB, Wilson JB, Gu LH, Huisman TH: Hb Ethiopia or alpha 2(140)(HC2)Tyr----His beta 2. Hemoglobin. 1992;16(5):441-3. [PubMed:1428951]
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  19. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569]
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  21. Fermi G: Three-dimensional fourier synthesis of human deoxyhaemoglobin at 2-5 A resolution: refinement of the atomic model. J Mol Biol. 1975 Sep 15;97(2):237-56. [PubMed:1177322]
  22. Baldwin JM: The structure of human carbonmonoxy haemoglobin at 2.7 A resolution. J Mol Biol. 1980 Jan 15;136(2):103-28. [PubMed:7373648]
  23. Silva MM, Rogers PH, Arnone A: A third quaternary structure of human hemoglobin A at 1.7-A resolution. J Biol Chem. 1992 Aug 25;267(24):17248-56. [PubMed:1512262]
  24. Sutherland-Smith AJ, Baker HM, Hofmann OM, Brittain T, Baker EN: Crystal structure of a human embryonic haemoglobin: the carbonmonoxy form of gower II (alpha2 epsilon2) haemoglobin at 2.9 A resolution. J Mol Biol. 1998 Jul 17;280(3):475-84. [PubMed:9665850]
  25. Kavanaugh JS, Moo-Penn WF, Arnone A: Accommodation of insertions in helices: the mutation in hemoglobin Catonsville (Pro 37 alpha-Glu-Thr 38 alpha) generates a 3(10)-->alpha bulge. Biochemistry. 1993 Mar 16;32(10):2509-13. [PubMed:8448109]
  26. Botha MC, Beale D, Isaacs WA, Lehmann H: Hemoglobin J Cape Town-alpha-2 92 arginine replaced by glutamine beta-2. Nature. 1966 Nov 19;212(5064):792-5. [PubMed:5988206]
  27. Smith LL, Barton BP, Huisman TH: Subunit dissociation of the unstable hemoglobin Bibba (alpha 2-136Pro(H19)beta 2). J Biol Chem. 1970 Apr 25;245(8):2185-8. [PubMed:5440849]
  28. Nagel RL, Gibson QH, Jenkins T: Ligand binding in hemoglobin J Capetown. J Mol Biol. 1971 Jun 28;58(3):643-50. [PubMed:5091982]
  29. Charache S, Ostertag W, von Ehrenstein G: Clinical studies and physiological properties of Hopkins-2 haemoglobin. Nat New Biol. 1971 Dec 22;234(51):248-51. [PubMed:5288820]
  30. Wiltshire BG, Clark KG, Lorkin PA, Lehmann H: Haemoglobin Denmark Hill 95 (G2) Pro-Ala, a variant with unusual electrophoretic and oxygen-binding properties. Biochim Biophys Acta. 1972 Oct 31;278(3):459-64. [PubMed:5085669]
  31. Wajcman H, Belkhodja O, Labie D: Hb Setif: G1 (94) Asp-Tyr. A new chain hemoglobin variant with substitution of the residue involved in hydrogen bond between unlike subunits. FEBS Lett. 1972 Nov 1;27(2):298-300. [PubMed:4667378]
  32. Adams JG 3rd, Winter WP, Rucknagel DL, Spencer HH: Biosynthesis of hemoglobin Ann Arbor: evidence for catabolic and feedback regulation. Science. 1972 Jun 30;176(4042):1427-9. [PubMed:5033650]
  33. Sumida I, Ota Y, Imamura T, Yanase T: Hemoglobin Sawara: alpha 6(A4) aspartic acid leads to alanine. Biochim Biophys Acta. 1973 Sep 21;322(1):23-6. [PubMed:4744335]
  34. Pulsinelli PD, Perutz MF, Nagel RL: Structure of hemoglobin M Boston, a variant with a five-coordinated ferric heme. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3870-4. [PubMed:4521212]
  35. Alberti R, Mariuzzi GM, Artibani L, Bruni E, Tentori L: A new haemoglobin variant: J-Rovigo alpha 53 (E-2) alanine leads to aspartic acid. Biochim Biophys Acta. 1974 Mar 14;342(1):1-4. [PubMed:4824923]
  36. Ohba Y, Miyaji T, Matsuoka M, Yokoyama M, Numakura H: Hemoglobin Hirosaki (alpha 43 [CE 1] Phe replaced by Leu), a new unstable variant. Biochim Biophys Acta. 1975 Sep 9;405(1):155-60. [PubMed:1182166]
  37. Thillet J, Blouquit Y, Perrone F, Rosa J: Hemoglobin Pontoise alpha63 Ala replaced by Asp(E12). A new fast moving variant. Biochim Biophys Acta. 1977 Mar 28;491(1):16-22. [PubMed:849454]
  38. Sasaki J, Imamura T, Sumida I, Yanase T, Ohya M: Increased oxygen affinity for hemoglobin Sawara: alphaA4(6) aspartic acid replaced by alanine. Biochim Biophys Acta. 1977 Nov 25;495(1):183-6. [PubMed:20980]
  39. Brennan SO, Tauro GP, Melrose W: Haemoglobin Port Phillip alpha91 (FG3) Leu replaced by Pro, a new unstable haemoglobin. FEBS Lett. 1977 Sep 1;81(1):115-7. [PubMed:902765]
  40. Knuth A, Pribilla W, Marti HR, Winterhalter KH: Hemoglobin Moabit: alpha 86 (F7) Leu leads to Arg: a new unstable abnormal hemoglobin. Acta Haematol. 1979;61(3):121-4. [PubMed:108887]
  41. Marinucci M, Mavilio F, Massa A, Gabbianelli M, Fontanarosa PP, Camagna A, Ignesti C, Tentori L: A new abnormal human hemoglobin: Hb Prato (alpha 2 31 (B12) Arg leads to Ser beta 2). Biochim Biophys Acta. 1979 Jun 19;578(2):534-40. [PubMed:486536]
  42. Jue DL, Johnson MH, Patchen LC, Moo-Penn WF: Hemoglobin Dunn: alpha 6 (A4) aspartic acid replaced by asparagine. Hemoglobin. 1979;3(2-3):137-43. [PubMed:478975]
  43. Charache S, Brimhall B, Zaatari G: Oxygen affinity and stability of hemoglobin Dunn alpha 6(A4)Asp replaced by Asn): use of isoelectric focusing in recognition of a new abnormal hemoglobin. Am J Hematol. 1980;9(2):151-60. [PubMed:7435503]
  44. Honig GR, Vida LN, Shamsuddin M, Mason RG, Schlumpf HW, Luke RA: Hemoglobin Milledgeville (alpha 44 (CD2) Pro leads to Leu): a new variant with increased oxygen affinity. Biochim Biophys Acta. 1980 Dec 16;626(2):424-31. [PubMed:7213661]
  45. Giuliani A, Maffi D, Cappabianca MP, Tentori L: Hemoglobin Legnano (alpha 2 141 (HC3) Arg leads to Leu beta2) a new high oxygen affinity variant. Functional and structural studies. J Biochem. 1980 Nov;88(5):1233-7. [PubMed:7462179]
  46. Poyart C, Bursaux E, Arnone A, Bonaventura J, Bonaventura C: Structural and functional studies of hemoglobin Suresnes (arg 141 alpha 2 replaced by His beta 2). Consequences of disrupting an oxygen-linked anion-binding site. J Biol Chem. 1980 Oct 10;255(19):9465-73. [PubMed:7410435]
  47. Lee-Potter JP, Deacon-Smith RA, Lehmann H, Robb L: Haemoglobin Ferndown (alpha 6 [A4] aspartic acid replaced by valine). FEBS Lett. 1981 Apr 6;126(1):117-9. [PubMed:7238857]
  48. Nakatsuji T, Miwa S, Ohba Y, Miyaji T, Matsumoto N, Matsuoka I: Hemoglobin Tottori (alpha 59[E8] glycine replaced by valine). Hemoglobin. 1981;5(5):427-39. [PubMed:7275660]
  49. Harano T, Harano K, Ueda S, Shibata S, Imai K, Ohba Y, Shinohara T, Horio S, Nishioka K, Shirotani H: Hemoglobin Kawachi [alpha 44 (CE2) Pro leads to Arg]: a new hemoglobin variant of high oxygen affinity with amino acid substitution at alpha 1 beta 2 contact. Hemoglobin. 1982;6(1):43-9. [PubMed:7068434]
  50. Ohba Y, Hattori Y, Matsuoka M, Miyaji T, Fuyuno K: HB Kokura [alpha 47 (CE 5) Asp leads to Gly]: a slightly unstable variant. Hemoglobin. 1982;6(1):69-74. [PubMed:7068437]
  51. Moo-Penn WF, Baine RM, Jue DL, Johnson MH, McGuffey JE, Benson JM: Hemoglobin Evanston: alpha 14(A12) Trp leads to Arg. A variant hemoglobin associated with alpha-thalassemia-2. Biochim Biophys Acta. 1983 Sep 14;747(1-2):65-70. [PubMed:6882779]
  52. Harano T, Harano K, Shibata S, Ueda S, Imai K, Seki M: Hemoglobin Tokoname [alpha 139 (HC 1) Lys leads to Thr]: a new hemoglobin variant with a slightly increased oxygen affinity. Hemoglobin. 1983;7(1):85-90. [PubMed:6188720]
  53. Liu GY, Zhang GX, Nie SY, Luo HY, Teng YQ, Liu SP, Song M, Son L, Chen SS, Jia PC, Liang CC: A case of hemoglobin Iwata [alpha 87(F8)His leads to Arg] in China. Hemoglobin. 1983;7(3):279-82. [PubMed:6874376]
  54. Headlee MG, Nakatsuji T, Lam H, Wrightstone RN, Huisman TH: Hb Etobicoke, alpha 85(F5) Ser leads to Arg found in a newborn of French-Indian-English descent. Hemoglobin. 1983;7(3):285-7. [PubMed:6874377]
  55. Harano T, Harano K, Shibata S, Ueda S, Mori H, Seki M: Hemoglobin Aichi [alpha 50(CE8) His----Arg]: a new slightly unstable hemoglobin variant discovered in Japan. FEBS Lett. 1984 Apr 24;169(2):297-9. [PubMed:6714429]
  56. Nakatsuji T, Wilson JB, Huisman TH: Hb Cordele alpha(2)47 (CE5)Asp----Ala beta 2. A mildly unstable variant observed in black twins. Hemoglobin. 1984;8(1):37-46. [PubMed:6547117]
  57. Sciarratta GV, Ivaldi G, Molaro GL, Sansone G, Salkie ML, Wilson JB, Reese AL, Huisman TH: The characterization of hemoglobin Manitoba or alpha (2)102(G9)Ser----Arg beta 2 and hemoglobin Contaldo or alpha (2)103(G10)His----Arg beta 2 by high performance liquid chromatography. Hemoglobin. 1984;8(2):169-81. [PubMed:6547932]
  58. Honig GR, Shamsuddin M, Vida LN, Mompoint M, Valcourt E, Bowie LJ, Jones EC, Powers PA, Spritz RA, Guis M, et al.: Hemoglobin Evanston (alpha 14 Trp----Arg). An unstable alpha-chain variant expressed as alpha-thalassemia. J Clin Invest. 1984 Jun;73(6):1740-9. [PubMed:6725558]
  59. Shimasaki S: A new hemoglobin variant, hemoglobin Nunobiki [alpha 141 (HC3) Arg----Cys]. Notable influence of the carboxy-terminal cysteine upon various physico-chemical characteristics of hemoglobin. J Clin Invest. 1985 Feb;75(2):695-701. [PubMed:3973024]
  60. Baklouti F, Baudin-Chich V, Kister J, Marden M, Teyssier G, Poyart C, Delaunay J, Wajcman H: Increased oxygen affinity with normal heterotropic effects in hemoglobin Loire [alpha 88(F9)Ala----Ser]. Eur J Biochem. 1988 Nov 1;177(2):307-12. [PubMed:3142772]
  61. Groff P, Galacteros F, Kalmes G, Blouquit Y, Wajcman H: Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant. Hemoglobin. 1989;13(5):429-36. [PubMed:2599879]
  62. Ohba Y, Imai K, Uenaka R, Ami M, Fujisawa K, Itoh K, Hirakawa K, Miyaji T: Hb Miyano or alpha 41(C6)Thr----Ser: a new high oxygen affinity alpha chain variant found in an erythremic blood donor. Hemoglobin. 1989;13(7-8):637-47. [PubMed:2634665]
  63. Bardakdjian-Michau J, Rosa J, Galacteros F, Lancelot M, Marquart FX: Hb Reims [alpha 2(23)(B4)Glu----Gly beta 2]: a new alpha chain variant with slightly decreased stability. Hemoglobin. 1989;13(7-8):733-5. [PubMed:2634669]
  64. McDonald MJ, Michalski LA, Turci SM, Guillette RA, Jue DL, Johnson MH, Moo-Penn WF: Structural, functional, and subunit assembly properties of hemoglobin Attleboro [alpha 138 (H21) Ser----Pro], a variant possessing a site maturation at a critical C-terminal residue. Biochemistry. 1990 Jan 9;29(1):173-8. [PubMed:2108715]
  65. Hidaka K, Iuchi I, Kobayashi T, Katoh K, Yaguchi K: Hb Fukutomi [alpha 126(H9)Asp----Val]: a new hemoglobin variant with high oxygen affinity. Hemoglobin. 1990;14(5):499-509. [PubMed:2079432]
  66. Lendaro E, Ippoliti R, Brancaccio A, Bellelli A, Vallone B, Ivaldi G, Sciarratta GV, Castello C, Tomova S, Brunori M, et al.: Hemoglobin Dallas (alpha 97(G4)Asn-->Lys): functional characterization of a high oxygen affinity natural mutant. Biochim Biophys Acta. 1992 Oct 13;1180(1):15-20. [PubMed:1390940]
  67. Wajcman H, Kister J, Marden M, Lahary A, Monconduit M, Galacteros F: Hemoglobin Rouen (alpha-140 (HC2) Tyr-->His): alteration of the alpha-chain C-terminal region and moderate increase in oxygen affinity. Biochim Biophys Acta. 1992 Oct 13;1180(1):53-7. [PubMed:1390944]
  68. Abbes S, M'Rad A, Fitzgerald PA, Dormer P, Blouquit Y, Kister J, Galacteros F, Wajcman H: HB Al-Ain Abu Dhabi [alpha 18(A16)Gly----Asp]: a new hemoglobin variant discovered in an Emiratee family. Hemoglobin. 1992;16(5):355-62. [PubMed:1428941]
  69. Wajcman H, Vasseur C, Blouquit Y, Rosa J, Labie D, Najman A, Reman O, Leporrier M, Galacteros F: Unstable alpha-chain hemoglobin variants with factitious beta-thalassemia biosynthetic ratio: Hb Questembert (alpha 131[H14]Ser-->Pro) and Hb Caen (alpha 132[H15]Val-->Gly). Am J Hematol. 1993 Apr;42(4):367-74. [PubMed:8493987]
  70. Curuk MA, Dimovski AJ, Baysal E, Gu LH, Kutlar F, Molchanova TP, Webber BB, Altay C, Gurgey A, Huisman TH: Hb Adana or alpha 2(59)(E8)Gly-->Asp beta 2, a severely unstable alpha 1-globin variant, observed in combination with the -(alpha)20.5 Kb alpha-thal-1 deletion in two Turkish patients. Am J Hematol. 1993 Dec;44(4):270-5. [PubMed:8237999]
  71. Wajcman H, Kister J, Galacteros F, Spielvogel A, Lin MJ, Vidugiris GJ, Hirsch RE, Friedman JM, Nagel RL: Hb Montefiore (126(H9)Asp-->Tyr). High oxygen affinity and loss of cooperativity secondary to C-terminal disruption. J Biol Chem. 1996 Sep 20;271(38):22990-8. [PubMed:8798486]
  72. Fujiwara N, Maekawa T, Matsuda G: Hemoglobin Atago (alpha2-85Tyr beta-2) a new abnormal human hemoglobin found in Nagasaki. Biochemical studies on hemoglobins and myoglobins. VI. Int J Protein Res. 1971;3(1):35-9. [PubMed:5115619]
  73. Brennan SO, Matthews JR: Hb Auckland [alpha 87(F8) His-->Asn]: a new mutation of the proximal histidine identified by electrospray mass spectrometry. Hemoglobin. 1997 Sep;21(5):393-403. [PubMed:9322075]
  74. Wajcman H, Kister J, M'Rad A, Soummer AM, Galacteros F: Hb Cemenelum [alpha 92 (FG4) Arg-->Trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity. Ann Hematol. 1994 Feb;68(2):73-6. [PubMed:8148419]
  75. Zeng YT, Huang SZ, Qiu XK, Cheng GC, Ren ZR, Jin QC, Chen CY, Jiao CT, Tang ZG, Liu RH, et al.: Hemoglobin Chongqing [alpha 2(NA2)Leu----Arg] and hemoglobin Harbin [alpha 16(A14)Lys----Met] found in China. Hemoglobin. 1984;8(6):569-81. [PubMed:6526652]
  76. Ayala S, Colomer D, Gelpi JL, Corrons JL: alpha-Thalassaemia due to a single codon deletion in the alpha1-globin gene. Computational structural analysis of the new alpha-chain variant. Mutations in brief no. 132. Online. Hum Mutat. 1998;11(5):412. [PubMed:10206681]
  77. Wilson JB, Webber BB, Plaseska D, de Alarcon PA, McMillan SK, Huisman TH: Hb Davenport or alpha 2(78)(EF7)Asn----His beta 2. Hemoglobin. 1990;14(6):599-605. [PubMed:2101836]
  78. Wilson JB, Webber BB, Kutlar A, Reese AL, McKie VC, Lutcher CL, Felice AE, Huisman TH: Hb Evans or alpha 262(E11)Val----Met beta 2; an unstable hemoglobin causing a mild hemolytic anemia. Hemoglobin. 1989;13(6):557-66. [PubMed:2606724]
  79. Cash FE, Monplaisir N, Goossens M, Liebhaber SA: Locus assignment of two alpha-globin structural mutants from the Caribbean basin: alpha Fort de France (alpha 45 Arg) and alpha Spanish Town (alpha 27 Val). Blood. 1989 Aug 1;74(2):833-5. [PubMed:2752146]
  80. Wajcman H, Kister J, Riou J, Galacteros F, Girot R, Maier-Redelsperger M, Nayudu NV, Giordano PC: Hb Godavari [alpha 95(G2)Pro-->Thr]: a neutral amino acid substitution in the alpha 1 beta 2 interface that modifies the electrophoretic mobility of hemoglobin. Hemoglobin. 1998 Jan;22(1):11-22. [PubMed:9494044]
  81. Huisman TH, Wilson JB, Gravely M, Hubbard M: Hemoglobin Grady: the first example of a variant with elongated chains due to an insertion of residues. Proc Natl Acad Sci U S A. 1974 Aug;71(8):3270-3. [PubMed:4528583]
  82. Orisaka M, Tajima T, Harano T, Harano K, Kushida Y, Imai K: A new alpha chain variant, Hb Hanamaki or alpha 2(139)(HC1)Lys----Glu beta 2, found in a Japanese family. Hemoglobin. 1992;16(1-2):67-71. [PubMed:1634363]
  83. Harano T, Harano K, Shibata S, Ueda S, Imai K, Seki M: HB Handa [alpha 90 (FG 2) Lys replaced by Met]: structure and biosynthesis of a new slightly higher oxygen affinity variant. Hemoglobin. 1982;6(4):379-89. [PubMed:6815131]
  84. Charache S, Mondzac AM, Gessner U: Hemoglobin Hasharon (alpha-2-47 his(CD5)beta-2): a hemoglobin found in low concentration. J Clin Invest. 1969 May;48(5):834-47. [PubMed:5780195]
  85. Fleming PJ, Sumner DR, Wyatt K, Hughes WG, Melrose WD, Jupe DM, Baikie MJ: Hemoglobin Hobart or alpha 20(Bl)His----Arg: a new alpha chain hemoglobin variant. Hemoglobin. 1987;11(3):211-20. [PubMed:3654264]
  86. Reed RE, Winter WP, Rucknagel DL: Haemoglobin inkster (alpha2 85aspartic acid leads to valine beta2) coexisting with beta-thalassaemia in a Caucasian family. Br J Haematol. 1974 Mar;26(3):475-84. [PubMed:4212045]
  87. Miyashita H, Hashimoto K, Mohri H, Ohokubo T, Harano T, Harano K, Imai K: Hb Kanagawa [alpha 40(C5)Lys----Met]: a new alpha chain variant with an increased oxygen affinity. Hemoglobin. 1992;16(1-2):1-10. [PubMed:1634355]
  88. Giordano PC, Harteveld CL, Streng H, Oosterwijk JC, Heister JG, Amons R, Bernini LF: Hb Kurdistan [alpha 47(CE5)Asp-->Tyr], a new alpha chain variant in combination with beta (0)-thalassemia. Hemoglobin. 1994 Jan;18(1):11-8. [PubMed:8195005]
  89. Harano T, Harano K, Imai K, Murakami T, Matsubara H: Hb Kurosaki [alpha 7(A5)Lys-->Glu]: a new alpha chain variant found in a Japanese woman. Hemoglobin. 1995 May-Jul;19(3-4):197-201. [PubMed:7558876]
  90. Yalcin A, Avcu F, Beyan C, Gurgey A, Ural AU: A case of HB J-Meerut (or Hb J-Birmingham) [alpha 120(H3)Ala-->Glu]. Hemoglobin. 1994 Nov;18(6):433-5. [PubMed:7713747]
  91. Wajcman H, Kalmes G, Groff P, Prome D, Riou J, Galacteros F: Hb Melusine [alpha 114(GH2)Pro-->Ser]: a new neutral hemoglobin variant. Hemoglobin. 1993 Oct;17(5):397-405. [PubMed:8294199]
  92. Brimhall B, Jones RT, Schneider RG, Hosty TS, Tomlin G, Atkins R: Two new hemoglobins. Hemoglobin Alabama (beta39(C5)Gln leads to Lys) and hemoglobin Montgomery (alpha 48(CD 6) Leu leads to Arg). Biochim Biophys Acta. 1975 Jan 30;379(1):28-32. [PubMed:1115799]
  93. Honig GR, Shamsuddin M, Zaizov R, Steinherz M, Solar I, Kirschmann C: Hemoglobin Petah Tikva (alpha 110 ala replaced by asp): a new unstable variant with alpha-thalassemia-like expression. Blood. 1981 Apr;57(4):705-11. [PubMed:7470621]
  94. Wajcman H, Prehu MO, Prehu C, Blouquit Y, Prome D, Galacteros F: Hemoglobin Phnom Penh [alpha117Phe(H1)-Ile-alpha118Thr(H2)]; evidence for a hotspot for insertion of residues in the third exon of the alpha1-globin gene. Hum Mutat. 1998;Suppl 1:S20-2. [PubMed:9452028]
  95. Zwerdling T, Williams S, Nasr SA, Rucknagel DL: Hb Port Huron [alpha 56 (E5)Lys----ARG]: a new alpha chain variant. Hemoglobin. 1991;15(5):381-91. [PubMed:1802882]
  96. Zeng YT, Huang SZ, Zhou XD, Qiu XK, Dong QY, Li MY, Bai JH: Hb Shenyang (alpha 26 (B7) Ala replaced by Glu): a new unstable variant found in China. Hemoglobin. 1982;6(6):625-8. [PubMed:7161109]
  97. Sanguansermsri T, Matragoon S, Changloah L, Flatz G: Hemoglobin Suan-Dok (alpha 2 109 (G16) Leu replaced by Arg beta 2): an unstable variant associated with alpha-thalassemia. Hemoglobin. 1979;3(2-3):161-74. [PubMed:478977]
  98. Ohba Y, Yamamoto K, Hattori Y, Kawata R, Miyaji T: Hyperunstable hemoglobin Toyama [alpha 2 136(H19)Leu----Arg beta 2]: detection and identification by in vitro biosynthesis with radioactive amino acids. Hemoglobin. 1987;11(6):539-56. [PubMed:2833478]
  99. Harkness M, Harkness DR, Kutlar F, Kutlar A, Wilson JB, Webber BB, Codrington JF, Huisman TH: Hb Sun Prairie or alpha(2)130(H13)Ala----Pro beta 2, a new unstable variant occurring in low quantities. Hemoglobin. 1990;14(5):479-89. [PubMed:2079430]
  100. Harano T, Harano K, Imai K, Terunuma S: HB Swan River [alpha 6(A4)ASP-->Gly] observed in a Japanese man. Hemoglobin. 1996 Feb;20(1):75-8. [PubMed:8745434]
  101. Vasseur C, Blouquit Y, Kister J, Prome D, Kavanaugh JS, Rogers PH, Guillemin C, Arnone A, Galacteros F, Poyart C, et al.: Hemoglobin Thionville. An alpha-chain variant with a substitution of a glutamate for valine at NA-1 and having an acetylated methionine NH2 terminus. J Biol Chem. 1992 Jun 25;267(18):12682-91. [PubMed:1618774]
  102. Darbellay R, Mach-Pascual S, Rose K, Graf J, Beris P: Haemoglobin Tunis-Bizerte: a new alpha 1 globin 129 Leu-->Pro unstable variant with thalassaemic phenotype. Br J Haematol. 1995 May;90(1):71-6. [PubMed:7786798]
  103. Langdown JV, Davidson RJ, Williamson D: A new alpha chain variant, Hb Turriff [alpha 99(G6)Lys----Glu]: the interference of abnormal hemoglobins in Hb A1c determination. Hemoglobin. 1992;16(1-2):11-7. [PubMed:1634357]
  104. Wajcman H, Kister J, M'Rad A, Marden MC, Riou J, Galacteros F: Hb Val de Marne [alpha 133(H16)Ser-->Arg]: a new hemoglobin variant with moderate increase in oxygen affinity. Hemoglobin. 1993 Oct;17(5):407-17. [PubMed:8294200]
  105. Jiang NH, Liang S, Wen XJ, Liang R, Su C, Tang Z: Hb Westmead: an alpha 2-globin gene mutation detected by polymerase chain reaction and Stu I cleavage. Hemoglobin. 1991;15(4):291-5. [PubMed:1686260]
  106. Como PF, Barber S, Sage RE, Trent RJ, Kronenberg H: Hemoglobin Woodville: alpha (2)6(A4) aspartic acid----tyrosine. Hemoglobin. 1986;10(2):135-41. [PubMed:3754246]
  107. Fujisawa K, Hattori Y, Ohba Y, Ando S: Hb Yuda or alpha 130(H13)Ala----Asp; a new alpha chain variant with low oxygen affinity. Hemoglobin. 1992;16(5):435-9. [PubMed:1428950]
  108. Wajcman H, Blouquit Y, Vasseur C, Le Querrec A, Laniece M, Melevendi C, Rasore A, Galacteros F: Two new human hemoglobin variants caused by unusual mutational events: Hb Zaire contains a five residue repetition within the alpha-chain and Hb Duino has two residues substituted in the beta-chain. Hum Genet. 1992 Aug;89(6):676-80. [PubMed:1511986]
  109. Traeger-Synodinos J, Harteveld CL, Kanavakis E, Giordano PC, Kattamis C, Bernini LF: Hb Aghia Sophia [alpha62(E11)Val-->0 (alpha1)], an "in-frame" deletion causing alpha-thalassemia. Hemoglobin. 1999 Nov;23(4):317-24. [PubMed:10569720]
  110. Lacan P, Francina A, Souillet G, Aubry M, Couprie N, Dementhon L, Becchi M: Two new alpha chain variants: Hb Boghe [alpha58(E7)His-->Gln, alpha2], a variant on the distal histidine, and Hb CHarolles [alpha103(G10)His-Tyr, alpha1]. Hemoglobin. 1999 Nov;23(4):345-52. [PubMed:10569723]
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  112. Abdulmalik O, Safo MK, Lerner NB, Ochotorena J, Daikhin E, Lakka V, Santacroce R, Abraham DJ, Asakura T: Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity. Am J Hematol. 2004 Nov;77(3):268-76. [PubMed:15495251]
  113. Martin G, Villegas A, Gonzalez FA, Ropero P, Hojas R, Polo M, Mateo M, Salvador M, Benavente C: A novel mutation of the alpha2-globin causing alpha(+)-thalassemia: Hb Plasencia [alpha125(H8)Leu--Arg (alpha2). Hemoglobin. 2005;29(2):113-7. [PubMed:15921163]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00358Mefloquineapproved, investigationalyesantagonistDetails
DB00893Iron Dextranapproved, vet_approvedyesactivatorDetails
DB074272-[(2-methoxy-5-methylphenoxy)methyl]pyridineexperimentalunknownDetails
DB074284-[(5-methoxy-2-methylphenoxy)methyl]pyridineexperimentalunknownDetails
DB021264-Carboxycinnamic AcidexperimentalunknownDetails
DB07645SEBACIC ACIDexperimentalunknownDetails
DB080772-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACIDexperimentalunknownDetails
DB082622,6-dicarboxynaphthaleneexperimentalunknownDetails
DB08486EfaproxiralinvestigationalunknownDetails
DB086321,3,5-BENZENETRICARBOXYLIC ACIDexperimentalunknownDetails
DB09146Iron sucroseapprovedyescomponent ofDetails
DB09517Sodium ferric gluconate complexapprovedunknownbindingDetails
DB09112Nitrous acidapproved, investigationalyesoxidizerDetails
DB09140Oxygenapproved, vet_approvedunknownDetails
DB01592IronapprovedunknownDetails
DB09130Copperapproved, investigationalunknownDetails
DB01593Zincapproved, investigationalunknownDetails
DB09147Ferric pyrophosphateexperimentalyesbinderDetails
DB13995Ferric pyrophosphate citrateapproved, investigationalyesbinderDetails
DB06154Pentaerythritol tetranitrateapprovedyesagonistDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14488Ferrous gluconateapprovedunknownDetails
DB14489Ferrous succinateapprovedunknownDetails
DB14490Ferrous ascorbateapprovedunknownDetails
DB14491Ferrous fumarateapprovedunknownDetails
DB14501Ferrous glycine sulfateapprovedunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownDetails