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Displaying drugs 76 - 100 of 103 in total

Lubiprostone

Lubiprostone is a medication used in the management of idiopathic chronic constipation. A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. Activation of these channels promotes the secretion of a chloride-rich fluid that soften...
Approved
Investigational
Matched Description: … gastrointestinal motility, and induce spontaneous bowel movements (SBM). ... A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels ... Activation of these channels promotes the secretion of a chloride-rich fluid that soften the stool, increase …
Matched Categories: … Chloride Channel Agonists ... Alimentary Tract and Metabolism …

Magnesium

Magnesium is classified as an alkaline earth metal and has 2 hydration shells. The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate. Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy...
Approved
Experimental
Investigational
Matched Description: … and magnesium carbonate. ... [A32810] Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein ... Magnesium is classified as an alkaline earth metal and has 2 hydration shells. …
Matched Mixtures name: … CALCIUM AND MAGNESIUM PLUS C,POTASSIUM AND ZINC TABLET ... Calcium & Magnesium Plus Potassium & Zinc ... Calcium & Magnesium With Potassium & Zinc …

Glyburide

Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. It is typically given to patients who cannot be managed with the standard first line therapy, metformin. Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and...
Approved
Matched Description: … on beta cells, raising intracellular potassium and calcium ion concentrations. ... [L8123] Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels …
Matched Mixtures name: … Glyburide and Metformin ... Glyburide and Metformin ... Glyburide and Metformin …
Matched Categories: … Alimentary Tract and Metabolism …

Loperamide

Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as diphenoxylate and haloperidol. Due to...
Approved
Matched Description: … withdrawal symptoms and to induce euphoria. ... [L42785] The drug was first synthesized in 1969 and used medically in 1976. ... [A6249] Due to pharmacological properties, loperamide has been misused and abused to self-manage opioid …
Matched Mixtures name: … Anti Diarrheal and Anti Gas ... Anti Diarrheal and Anti Gas ... Up and Up Anti Diarrheal Anti Gas …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Up and Up anti diarrheal ... Berkley and Jensen Anti Diarrheal ... Foster and Thrive Anti-diarrheal …

Halothane

A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Approved
Vet approved

Isoflurane

A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Approved
Vet approved

Plasma protein fraction (human)

The plasma protein fraction human (PPFh) is defined as a sterile solution of proteins composed mainly of albumin and globulin derived from human plasma. It is already reviewed under the category of biologics by the FDA where the processing, required tests, requirements and labeling are incorporated. This biologic should come...
Approved
Matched Description: … some electrolytes such as sodium, potassium and chloride. ... [L2262] The proteins in PPFh are stabilized with sodium caprylate and acetyltryptophan and it contains ... protein fraction human (PPFh) is defined as a sterile solution of proteins composed mainly of albumin and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Magnesium gluconate

Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used...
Approved
Investigational
Matched Description: … Although magnesium is available in the form of sulphates, lactate, hydroxide, oxide and chloride, only ... and laxatives) [L2601]. ... It demonstrates the highest oral bioavailability of magnesium salts [L2608] and is used as a mineral …
Matched Mixtures name: … NUTROPLEX LIQUID WITH IRON AND LYSINE …
Matched Categories: … Alimentary Tract and Metabolism …

Clonidine

Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.
Approved
Matched Description: … [A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD. …
Matched Categories: … clonidine and diuretics ... Antiglaucoma Preparations and Miotics ... clonidine and diuretics, combinations with other drugs …

Baclofen

Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and...
Approved
Matched Description: … [A245338] Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the ... [L39429] Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence ... used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Lofexidine

Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment...
Approved
Investigational
Matched Description: … [T209] Lofexidine was developed by US Woldmeds LLC and it was approved by the FDA on May 16, 2018. ... Lofexidine was then repurposed for the treatment of opioid withdrawal, as it was seen to be more economical and …

Prucalopride

Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC...
Approved
Matched Description: … A40250] in Canada on December 7, 2011 and by the FDA on December 17, 2018. ... [A40254] Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009,[ ... dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and …
Matched Categories: … Alimentary Tract and Metabolism …

Lysine

Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as...
Approved
Nutraceutical
Matched Description: … Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. ... The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. ... posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and …
Matched Mixtures name: … Effervescent Potassium Chloride ... Aminosyn II and Dextrose ... Aminosyn II and Dextrose …
Matched Categories: … arginine and lysine ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins ... Blood Substitutes and Perfusion Solutions …

Calcium magnesium potassium carbonate chloride hydroxide

Experimental
Matched Name: … Calcium magnesium potassium carbonate chloride hydroxide …
Matched Iupac: … calcium magnesium(2+) dipotassium(2+) chloride trihydroxide carbonate …

Tetraethylammonium

Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. As an experimental agent, tetraethylammonium is used in its salt forms such as tetraethylammonium chloride and tetraethylammonium bromide....
Experimental
Investigational
Matched Description: … voltage- activated potassium channels, and nicotinic acetylcholine receptors. ... Structurally, tetraethylammonium is positively charged due to its central quaternary ammonium. ... As an experimental agent, tetraethylammonium is used in its salt forms such as tetraethylammonium chloride …
Matched Salts name: … Tetraethylammonium chloride ... Tetraethylammonium iodide …
Matched Categories: … Potassium Channel Blockers ... Quaternary Ammonium Compounds …

Epitizide

Epitizide is an agent, commonly found in combination triamterene, used to produce diuresis.
Experimental
Matched Categories: … epitizide and potassium-sparing agents ... Low-Ceiling Diuretics and Potassium-Sparing Agents ... Sodium Chloride Symporter Inhibitors …

Tridihexethyl

Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug. Tridihexethyl is no longer available in the US market.
Withdrawn
Matched Description: … Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical ... studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. …
Matched Salts name: … Tridihexethyl chloride …
Matched Categories: … Alimentary Tract and Metabolism ... Ammonium Compounds ... Synthetic Anticholinergics, Quaternary Ammonium Compounds …

Methyclothiazide

A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
Withdrawn
Matched Categories: … methyclothiazide and potassium ... Sodium Chloride Symporter Inhibitors …

Azosemide

Azosemide is a loop diuretic used to treat hypertension, edema, and ascites.
Investigational
Matched Description: … Azosemide is a loop diuretic used to treat hypertension, edema, and ascites. …
Matched Categories: … Sodium Potassium Chloride Symporter Inhibitors …

Tripamide

Experimental
Matched Categories: … Sodium Potassium Chloride Symporter Inhibitors …

Bamocaftor

Bamocaftor (VX-659) is under investigation in clinical trial NCT03224351 (A Study Evaluating the Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis).
Investigational
Matched Description: … Bamocaftor (VX-659) is under investigation in clinical trial NCT03224351 (A Study Evaluating the Safety and …
Matched Salts name: … Bamocaftor potassium …
Matched Categories: … Chloride Channel Agonists …

Mebutizide

Experimental
Matched Categories: … mebutizide and potassium-sparing agents ... Low-Ceiling Diuretics and Potassium-Sparing Agents …

Clofenamide

Experimental
Matched Categories: … clofenamide and potassium …

Calcium

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the...
Nutraceutical
Matched Description: … Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, ... Calcium gluconate and calcium lactate are absorbed well by pregnant women. ... Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. …
Matched Mixtures name: … Magnesium Chloride ... CALCIUM AND MAGNESIUM PLUS C,POTASSIUM AND ZINC TABLET ... Calcium & Magnesium Plus Potassium & Zinc …
Matched Categories: … Antacids and Adsorbents ... Alimentary Tract and Metabolism ... multivitamins and calcium ... ascorbic acid (vit C) and calcium ... Calcium-Regulating Hormones and Agents …

Mefruside

Experimental
Matched Categories: … mefruside and potassium …
Displaying drugs 76 - 100 of 103 in total