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Identification
NameLoperamide
Accession NumberDB00836  (APRD00275)
TypeSmall Molecule
GroupsApproved
DescriptionOne of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally. [PubChem]
Structure
Thumb
Synonyms
Loperamid
Loperamida
Lopéramide
Loperamidum
External Identifiers
  • PJ 185
  • R 18553
Approved Prescription ProductsNot Available
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Loperamide HydrochlorideCapsule2 mg/1OralCardinal Health1991-09-182015-12-29Us
Loperamide HydrochlorideCapsule2 mg/1OralUnit Dose Services2012-10-12Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-10-12Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralClinical Solutions Wholesale1993-05-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralA S Medication Solutions1993-05-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralREMEDYREPACK INC.2011-11-162016-11-29Us
Loperamide HydrochlorideCapsule2 mg/1OralPd Rx Pharmaceuticals, Inc.2011-09-23Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralAphena Pharma Solutions Tennessee, Llc2012-10-12Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralMylan Institutional Inc.1997-10-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralA S Medication Solutions1993-05-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralSTAT Rx USA LLC1993-05-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralDIRECT RX2014-01-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralNu Care Pharmaceuticals, Inc.1993-05-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralPhysicians Total Care, Inc.1996-06-20Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralREMEDYREPACK INC.2013-03-18Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralPd Rx Pharmaceuticals, Inc.2012-10-12Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralPreferred Pharmaceuticals, Inc.2011-01-28Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralNorthwind Pharmaceuticals, LLC2014-10-22Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralTeva Pharmaceuticals Usa, Inc.1993-05-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralRebel Distributors Corp1992-04-30Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1Oralbryant ranch prepack1993-05-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralRed Pharm Drug, Inc.2016-04-13Not applicableUs
Loperamide HydrochlorideSolution2 mg/10mLOralCardinal Health1992-04-30Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralPd Rx Pharmaceuticals, Inc.1993-05-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralLake Erie Medical DBA Quality Care Products LLC2010-10-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralMc Kesson Contract Packaging2012-01-26Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralREMEDYREPACK INC.2013-02-11Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralMylan Pharmaceuticals Inc.1991-09-18Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralAidarex Pharmaceuticals LLC1993-05-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralDispensing Solutions, Inc.2011-09-23Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralRed Pharm Drug, Inc.2011-01-01Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralCardinal Health2011-07-27Not applicableUs
Loperamide HydrochlorideCapsule2 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs1993-05-01Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select Anti DiarrhealTablet, film coated2 mg/1Oral7 Eleven2014-08-05Not applicableUs
A DTablet, film coated2 mg/1OralWestern Family Foods Inc2003-04-10Not applicableUs
A DTablet, film coated2 mg/1OralWestern Family Foods Inc2003-02-25Not applicableUs
Alti-loperamide - 2mg CapletTablet2 mgOralAltimed Pharma Inc.1995-12-311997-08-14Canada
Anti DiarrhealTablet, film coated2 mg/1OralMajor Pharmaceuticals2003-02-24Not applicableUs
Anti DiarrhealSolution1 mg/5mLOralRebel Distributors Corp1992-07-13Not applicableUs
Anti DiarrhealSolution1 mg/5mLOralRite Aid Corporation1992-07-13Not applicableUs
Anti DiarrhealCapsule2 mg/1OralWal Mart Stores Inc2005-05-032015-12-29Us
Anti DiarrhealTablet, film coated2 mg/1OralH E B2014-05-01Not applicableUs
Anti DiarrhealTablet2 mg/1OralHarmon Store Inc.2005-05-03Not applicableUs
Anti DiarrhealTablet2 mg/1OralL.N.K. International, Inc.2005-05-03Not applicableUs
Anti DiarrhealTablet2 mg/1OralBedrock Brands, Llc2005-05-032019-07-08Us
Anti DiarrhealTablet, film coated2 mg/1OralShopko Stores Operating Co., LLC2003-03-07Not applicableUs
Anti DiarrhealTablet, film coated2 mg/1OralPreferred Pharmaceuticals Inc.2015-11-20Not applicableUs
Anti DiarrhealTablet, film coated2 mg/1OralCVS Pharmacy2003-04-21Not applicableUs
Anti DiarrhealTablet, film coated2 mg/1OralREMEDYREPACK INC.2016-05-17Not applicableUs
Anti DiarrhealTablet, film coated2 mg/1OralKroger Company2003-03-31Not applicableUs
Anti DiarrhealTablet, film coated2 mg/1OralPublix Super Markets Inc2003-03-19Not applicableUs
Anti DiarrhealTablet, film coated2 mg/1OralMeijer Distribution Inc2003-03-05Not applicableUs
Anti DiarrhealTablet, film coated2 mg/1OralHy Vee Inc2003-03-21Not applicableUs
Anti DiarrhealTablet2 mg/1OralArmy and Air Force Exchange Service2005-05-03Not applicableUs
Anti DiarrhealTablet, film coated2 mg/1OralCVS Pharmacy2003-02-24Not applicableUs
Anti DiarrhealTablet, film coated2 mg/1OralKroger Company2003-02-21Not applicableUs
Anti DiarrhealSolution1 mg/5mLOralMeijer Distribution Inc1992-04-17Not applicableUs
Anti DiarrhealTablet2 mg/1OralSam's West Inc2005-05-03Not applicableUs
Anti DiarrhealCapsule2 mg/1OralNash Finch Company2005-05-03Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralQUALITY CHOICE (Chain Drug Marketing Association)2013-05-31Not applicableUs
Anti-diarrhealTablet2 mg/1OralPreferred Pharmaceuticals Inc.2016-08-25Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralASSURED / DOLLAR TREE (Greenbrier International, Inc.)2013-11-20Not applicableUs
Anti-diarrhealTablet2 mg/1OralWalgreen Company2005-05-03Not applicableUs
Anti-diarrhealTablet2 mg/1OralFamily Dollar Services Inc2005-05-03Not applicableUs
Anti-diarrhealTablet2 mg/1OralSam's West Inc2005-05-03Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralGood Sense (Geiss, Destin & Dunn, Inc.)2010-07-15Not applicableUs
Anti-diarrhealTablet2 mg/1OralL&R Distributors, Inc.2005-05-03Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralCVS Pharmacy2010-07-08Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralBest Choice (Valu Merchandisers Company)2010-08-30Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralWalgreens2012-05-30Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2011-11-10Not applicableUs
Anti-diarrhealTablet2 mg/1OralBetter Living Brands, Llc2005-05-03Not applicableUs
Anti-diarrhealTablet2 mg/1OralSUPERVALU INC.2005-05-03Not applicableUs
Anti-diarrhealTablet2 mg/1OralL.N.K. International, Inc.2005-05-03Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralHy Vee2016-06-30Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralCare One (American Sales Company)2010-08-05Not applicableUs
Anti-diarrhealTablet2 mg/1OralGreenbrier International, Inc.2005-05-03Not applicableUs
Anti-diarrhealTablet2 mg/1OralREMEDYREPACK INC.2016-09-01Not applicableUs
Anti-diarrhealTablet2 mg/1OralGeri Care Pharmaceutical Corp2006-01-01Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralAmerisource Bergen (Good Neighbor Pharmacy) 461222013-06-07Not applicableUs
Anti-diarrhealTablet2 mg/1OralChain Drug Consortium2005-05-03Not applicableUs
Anti-diarrhealTablet2 mg/1OralCVS Pharmacy2005-05-032018-11-30Us
Anti-diarrhealTablet2 mg/1OralH E B2005-05-03Not applicableUs
Anti-diarrhealTablet2 mg/1OralRite Aid Corporation2005-05-03Not applicableUs
Anti-diarrhealTablet2 mg/1OralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.2005-05-03Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralFreds Inc2010-07-08Not applicableUs
Anti-diarrhealCapsule, liquid filled2 mg/1OralMEIJER, INC.2016-08-31Not applicableUs
Anti-diarrheal Caplets - 2mgTablet2 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1995-12-312007-08-01Canada
Anti-diarrheal Loperamide HClCapsule, liquid filled2 mg/1OralTOP CARE (Topco Associates LLC)2010-07-16Not applicableUs
Anti-diarrheal Loperamide HClCapsule, liquid filled2 mg/1OralMc Kesson (Sunmark)2010-07-09Not applicableUs
Anti-diarrheal Loperamide HClCapsule, liquid filled2 mg/1OralEQUATE (Walmart Stores, Inc.)2013-01-15Not applicableUs
Anti-diarrheal Loperamide HClCapsule, liquid filled2 mg/1OralWestern Family Foods, Inc.2010-07-05Not applicableUs
Antidiarrheal ReliefTablet2 mg/1OralNorth Safety Products LLC2013-04-29Not applicableUs
Apo-loperamide - Tab 2mgTablet2 mgOralApotex Inc1996-12-31Not applicableCanada
Berkley and Jensen Anti DiarrhealTablet, film coated2 mg/1OralBJWC2003-04-19Not applicableUs
Care One Anti DiarrhealTablet, film coated2 mg/1OralAmerican Sales Company2004-01-23Not applicableUs
Care One Anti Diarrheal Loperamide HydrochlorideTablet, film coated2 mg/1OralAmerican Sales Company2004-01-23Not applicableUs
Careone Diarrhea ControlSuspension1 mg/7.5mLOralAmerican Sales Company2016-09-20Not applicableUs
Careone Diarrhea ControlTablet, film coated2 mg/1OralAmerican Sales Company2016-09-14Not applicableUs
Careone Diarrhea ControlSuspension1 mg/7.5mLOralAmerican Sales Company2016-11-23Not applicableUs
Careone Loperamide HydrochlorideSuspension1 mg/7.5mLOralAmerican Sales Company2014-05-10Not applicableUs
Careone Loperamide HydrochlorideSuspension1 mg/7.5mLOralAmerican Sales Company2012-05-21Not applicableUs
Circle K Anti-diarrhealTablet2 mg/1OralLil' Drug Store Products, Inc2014-11-01Not applicableUs
Dg Health Anti DiarrhealSuspension1 mg/7.5mLOralDolgencorp, LLC2015-11-19Not applicableUs
Dg Health Anti DiarrhealTablet, film coated2 mg/1OralDolgencorp, LLC2009-12-28Not applicableUs
Dg Health Loperamide HydrochlorideLiquid1 mg/7.5mLOralDolgencorp Inc2012-07-26Not applicableUs
Diahalt Caplets - 2mgTablet2 mgOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1997-04-112006-08-25Canada
Diarr-ezeTablet2 mgOralPharmascience Inc1997-02-18Not applicableCanada
Diarr-eze - Liq Orl 0.2mg/mlSolution.2 mgOralPharmascience Inc1997-02-25Not applicableCanada
Diarrhea ReliefTablet2 mgOralTeva Canada Limited2014-01-24Not applicableCanada
Diarrhea ReliefTablet2 mgOralPharmascience Inc2004-06-11Not applicableCanada
Diarrhea ReliefTablet2 mgOralVita Health Products Inc2004-12-19Not applicableCanada
Diarrhea ReliefTablet2 mgOralLaboratoire Riva Inc2016-09-20Not applicableCanada
Diarrhea Relief - Caplets 2mgTablet2 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1995-12-312002-07-31Canada
Diarrhea Relief Liquid GelsCapsule2 mgOralPharmascience IncNot applicableNot applicableCanada
Dom-loperamide Caplets 2mgTablet2 mgOralDominion Pharmacal2001-06-20Not applicableCanada
Dom-loperamide Hydrochloride Solution-orlSolution.2 mgOralDominion Pharmacal1995-12-31Not applicableCanada
Equaline Anti DiarrhealTablet, film coated2 mg/1OralSupervalu Inc2004-09-03Not applicableUs
Equaline Loperamide HydrochlorideSuspension1 mg/7.5mLOralSupervalu Inc2012-02-06Not applicableUs
Equate Anti DiarrhealTablet, film coated2 mg/1OralWal Mart Stores Inc2003-02-14Not applicableUs
Equate Loperamide HydrochlorideSuspension1 mg/7.5mLOralWal Mart Stores Inc2011-10-07Not applicableUs
Fad First Aid Direct Anti-diarrhealTablet, film coated2 mg/1OralFirst Aid Direct2014-10-15Not applicableUs
Family Wellness Anti DiarrhealTablet, film coated2 mg/1OralFamily Dollar Services Inc2003-02-26Not applicableUs
Good Neighbor Pharmacy Anti DiarrhealSolution1 mg/5mLOralAmerisource Bergen2003-09-19Not applicableUs
Good Neighbor Pharmacy Anti DiarrhealTablet, film coated2 mg/1OralAmerisource Bergen2008-06-26Not applicableUs
Good Neighbor Pharmacy Anti DiarrhealTablet, film coated2 mg/1OralAmerisource Bergen2003-05-12Not applicableUs
Good Neighbor Pharmacy Loperamide HydrochlorideLiquid1 mg/7.5mLOralAmerisource Bergen2012-02-17Not applicableUs
Good Neighbor Pharmacy Loperamide HydrochlorideSuspension1 mg/7.5mLOralAmerisource Bergen2014-01-31Not applicableUs
Good Sense Anti DiarrhealTablet, film coated2 mg/1OralL Perrigo Company2003-02-25Not applicableUs
Good Sense Anti DiarrhealSolution1 mg/5mLOralL. Perrigo Company1992-03-30Not applicableUs
Good Sense Loperamide HydrochlorideSuspension1 mg/7.5mLOralL Perrigo Company2012-01-31Not applicableUs
Handy Solutions Anti-diarrhealTablet2 mg/1OralNavajo Manufacturing Company Inc.2016-09-21Not applicableUs
Harmon Face Values Anti DiarrhealTablet, film coated2 mg/1OralHarmon Stores Inc.2011-12-18Not applicableUs
Harris Teeter Anti DiarrhealTablet, film coated2 mg/1OralHarris Teeter, LLC2015-03-30Not applicableUs
Harris Teeter Loperamide HydrochlorideSuspension1 mg/7.5mLOralHarris Teeter, LLC2015-03-30Not applicableUs
Health Mart Anti DiarrhealTablet, film coated2 mg/1OralMc Kesson2012-03-20Not applicableUs
Health Mart Loperamide HydrochlorideLiquid1 mg/7.5mLOralMc Kesson2012-03-20Not applicableUs
Health Mart Loperamide HydrochlorideSuspension1 mg/7.5mLOralMc Kesson2014-06-11Not applicableUs
Healthy Accents Anti DiarrhealTablet, film coated2 mg/1OralDZA Brands LLC2008-02-04Not applicableUs
Imodium - Caplet 2mgTablet2 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1996-09-09Not applicableCanada
Imodium A-DSolution1 mg/7.5mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2005-01-01Not applicableUs
Imodium A-DTablet, film coated2 mg/1OralREMEDYREPACK INC.2015-10-20Not applicableUs
Imodium A-DTablet, film coated2 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2015-07-13Not applicableUs
Imodium A-DCapsule, liquid filled2 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2016-07-11Not applicableUs
Imodium AdTablet, coated2 mg/1OralLil' Drug Store Products, Inc.2010-05-10Not applicableUs
Imodium Calming LiquidSolution2 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2007-07-11Not applicableCanada
Imodium Cap 2mgCapsule2 mgOralJanssen Pharmaceutica, Division Of Janssen Ortho Inc.1983-12-311997-07-03Canada
Imodium Caplets 2mgTablet2 mgOralJanssen Pharmaceutica, Division Of Janssen Ortho Inc.1990-12-311999-06-16Canada
Imodium Liqui-gelsCapsule2 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2013-07-02Not applicableCanada
Imodium Oral Sol 0.2mg/mlLiquid.2 mgOralJanssen Pharmaceutica, Division Of Janssen Ortho Inc.1984-12-311996-09-10Canada
Imodium Quick DissolveTablet2 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1997-09-24Not applicableCanada
Kirkland Signature Anti DiarrhealTablet, film coated2 mg/1OralCostco Wholesale Company2003-02-26Not applicableUs
Leader Anti DiarrhealSolution1 mg/5mLOralCardinal Health1997-10-28Not applicableUs
Leader Anti DiarrhealTablet, film coated2 mg/1OralCardinal Health2003-04-02Not applicableUs
Leader Anti-diarrhealTablet, film coated2 mg/1OralCardinal Health2014-09-25Not applicableUs
Leader LoperamideSuspension1 mg/7.5mLOralCardinal Health2014-05-30Not applicableUs
Leader Loperamide HydrochlorideLiquid1 mg/7.5mLOralCardinal Health2012-03-28Not applicableUs
Leader Loperamide HydrochlorideSuspension1 mg/7.5mLOralCardinal Health2014-04-23Not applicableUs
Lil Drug Store Anti-diarrhealTablet2 mg/1OralLil' Drug Store Products, Inc.2012-09-012015-12-30Us
LoperacapTablet2 mgOralValeant Canada Lp Valeant Canada S.E.C.1996-09-24Not applicableCanada
LoperamideTablet2 mgOralApotex IncNot applicableNot applicableCanada
LoperamideTablet2 mgOralLaboratoires Trianon Inc2005-07-15Not applicableCanada
LoperamideTablet2 mgOralD.C. Labs Limited2001-07-062005-07-19Canada
Loperamide HClCapsule, liquid filled2 mg/1OralChain Drug Consortium, LLC2012-12-04Not applicableUs
Loperamide HClCapsule, liquid filled2 mg/1OralTarget Corporation2011-10-01Not applicableUs
Loperamide HClCapsule, liquid filled2 mg/1OralMc Kesson (Health Mart)2012-06-25Not applicableUs
Loperamide HCl Anti-diarrhealCapsule, liquid filled2 mg/1OralP & L Development, LLC2011-08-30Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralPrecision Dose Inc.2014-02-26Not applicableUs
Loperamide HydrochlorideTablet, film coated2 mg/1OralCVS Pharmacy2015-10-06Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralAurohealth LLC2015-12-15Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralShopko Stores Operating Co., LLC1993-02-01Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralMeijer Distribution Inc2012-05-11Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralREMEDYREPACK INC.2016-04-05Not applicableUs
Loperamide HydrochlorideTablet, film coated2 mg/1OralInternational Laboratories, Inc.2016-06-01Not applicableUs
Loperamide HydrochlorideSolution1 mg/5mLOralHi Tech Pharmacal Co., Inc.1995-11-17Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralFamily Dollar Services, Inc.1993-02-01Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralKroger Company2013-08-06Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralChain Drug Consortium, LLC1993-02-01Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralZee Medical Inc2014-01-16Not applicableUs
Loperamide HydrochlorideSolution2 mg/10mLOralPrecision Dose Inc.2009-08-182016-01-30Us
Loperamide HydrochlorideTablet2 mg/1OralFred's Inc.1993-02-01Not applicableUs
Loperamide HydrochlorideTablet, film coated2 mg/1OralCVS Pharmacy2015-12-04Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralCVS Pharmacy2012-02-28Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralRite Aid Corporation2012-05-23Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralValu Merchandisers Company1993-02-01Not applicableUs
Loperamide HydrochlorideTablet, film coated2 mg/1OralCentral Texas Community Health Centers2003-06-27Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralH E B2012-03-05Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralAmerisource Bergen1993-02-01Not applicableUs
Loperamide HydrochlorideSolution1 mg/5mLOralPrecision Dose Inc.2009-09-012016-01-30Us
Loperamide HydrochlorideTablet2 mg/1OralMedline Industries, Inc.1993-02-01Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralProficient Rx LP1993-02-01Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralWin Co Foods, Llc1993-02-01Not applicableUs
Loperamide HydrochlorideLiquid1 mg/7.5mLOralPreferred Pharmaceuticals, Inc.2013-03-08Not applicableUs
Loperamide HydrochlorideTablet2 mgOralVita Health Products Inc2000-06-012007-07-30Canada
Loperamide HydrochlorideLiquid1 mg/7.5mLOralWestern Family Foods Inc2012-05-19Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralSelect Brand1993-02-01Not applicableUs
Loperamide HydrochlorideLiquid1 mg/7.5mLOralShopko Stores Operating Co., LLC2013-08-08Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralPrecision Dose Inc.2014-02-26Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralOhm Laboratories Inc.1993-02-01Not applicableUs
Loperamide HydrochlorideLiquid1 mg/7.5mLOralMajor Pharmaceuticals2012-03-14Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralPhysicians Total Care, Inc.2011-09-24Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralChain Drug Marketing Association Inc.1993-02-01Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralWalgreen Company2012-05-18Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralHy Vee Inc2012-04-30Not applicableUs
Loperamide HydrochlorideTablet2 mg/1OralWin Co Foods, Llc1993-02-01Not applicableUs
Loperamide HydrochlorideSolution1 mg/5mLOralPreferred Pharmaceuticals, Inc.2012-07-27Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralWestern Family Foods Inc2014-05-21Not applicableUs
Loperamide HydrochlorideSuspension1 mg/7.5mLOralCVS Pharmacy2014-02-04Not applicableUs
Loperamide HydrochlorideSolution1 mg/5mLOralAtlantic Biologicals Corps1995-11-17Not applicableUs
Loperamide-2Tablet2 mgOralPro Doc Limitee1997-11-05Not applicableCanada
Medex Anti-diarrheal ReliefTablet2 mg/1OralMedex Merchandising, Llc2015-10-20Not applicableUs
Medique DiamodeTablet2 mg/1OralUnifirst First Aid Corporation2008-12-30Not applicableUs
Novo-loperamide Tablets-2mgTablet2 mgOralTeva Canada Limited1995-12-31Not applicableCanada
PHL-loperamideTablet2 mgOralPharmel Inc2007-08-13Not applicableCanada
PMS-loperamide - Caplet 2mgTablet2 mgOralPharmascience Inc1996-09-12Not applicableCanada
PMS-loperamide Hydrochloride Solution.2mg/mlSolution0.2 mgOralPharmascience Inc1993-12-31Not applicableCanada
Preferred Plus LoperamideSuspension1 mg/7.5mLOralKinray2014-05-27Not applicableUs
Preferred Plus Loperamide HydrochlorideTablet, film coated2 mg/1OralKinray2014-05-27Not applicableUs
Preferred Plus Loperamide HydrochlorideSuspension1 mg/7.5mLOralKinray2014-06-09Not applicableUs
Rexall Anti DiarrhealTablet, film coated2 mg/1OralDolgencorp, LLC2010-08-15Not applicableUs
Rexall Anti DiarrhealSolution1 mg/5mLOralDolgencorp, LLC2010-08-09Not applicableUs
Rhoxal-loperamideTablet2 mgOralRhoxalpharma Inc1997-12-022009-11-24Canada
Riva-loperamideTablet2 mgOralLaboratoire Riva Inc1998-08-27Not applicableCanada
Rx Act Anti DiarrhealSolution1 mg/5mLOralH E B1992-05-14Not applicableUs
Rx Act Anti DiarrhealTablet, film coated2 mg/1OralH E B2003-03-24Not applicableUs
Sandoz LoperamideTablet2 mgOralSandoz Canada Incorporated2004-11-10Not applicableCanada
Shoprite Anti DiarrhealTablet, film coated2 mg/1OralWakefern Food Corporation2013-09-17Not applicableUs
Simply Right Anti DiarrhealTablet, film coated2 mg/1OralSam's West Inc2003-04-29Not applicableUs
Smart Sense Anti DiarrhealTablet, film coated2 mg/1OralKmart Corporation2011-01-09Not applicableUs
Smart Sense Anti DiarrhealSuspension1 mg/7.5mLOralKmart Corporation2016-01-26Not applicableUs
Smart Sense Anti DiarrhealSolution1 mg/5mLOralKmart Corporation2011-02-03Not applicableUs
Smart Sense Loperamide HydrochlorideSuspension1 mg/7.5mLOralKmart Corporation2012-05-14Not applicableUs
Stomach Relief Anti DiarrhealTablet2 mg/1OralSelect Corporation2012-10-15Not applicableUs
Sunmark Anti DiarrhealTablet, film coated2 mg/1OralMc Kesson2003-06-27Not applicableUs
Sunmark Anti DiarrhealSolution1 mg/5mLOralMc Kesson2003-09-19Not applicableUs
Sunmark Loperamide HydrochlorideSuspension1 mg/7.5mLOralMc Kesson2014-02-18Not applicableUs
Topcare Anti DiarrhealTablet, film coated2 mg/1OralTopco Associates LLC2003-02-26Not applicableUs
Topcare Loperamide HydrochlorideSuspension1 mg/7.5mLOralTopco Associates LLC2012-06-05Not applicableUs
Up and Up Anti DiarrhealTablet2 mg/1OralTarget Corporation2009-07-20Not applicableUs
Up and Up Anti DiarrhealSuspension1 mg/7.5mLOralTarget Corporation2016-02-26Not applicableUs
Up and Up Anti DiarrhealSolution1 mg/5mLOralTarget Corporation2009-07-31Not applicableUs
Vaprino A-DTablet2 mg/1OralBoehringer Ingelheim Pharmaceuticals, Inc.2013-09-02Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Gadavyt Loperamide HClLiquid1 mg/5mLOralGadal Laboratories Inc2013-05-01Not applicableUs
International Brands
NameCompany
DimorNordic Drugs
FortasecEsteve
ImodiumJohnson & Johnson
Kaopectate IIChattem, Inc.
LopediumSandoz
Lopedium expressSandoz
LopexOrion
Maalox Anti-DiarrhealNovartis International AG
Pepto Diarrhea ControlProcter & Gamble
Brand mixtures
NameLabellerIngredients
Imodium Complete CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Imodium Complete Chewable TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Salts
Name/CASStructureProperties
Loperamide hydrochloride
Thumb
  • InChI Key: PGYPOBZJRVSMDS-UHFFFAOYSA-N
  • Monoisotopic Mass: 512.199733756
  • Average Mass: 513.498
DBSALT000709
Loperamide oxide
106900-12-3
Thumb
  • InChI Key: KXVSBTJVTUVNPM-UHFFFAOYSA-N
  • Monoisotopic Mass: 492.2179706
  • Average Mass: 493.04
DBSALT001714
Categories
UNII6X9OC3H4II
CAS number53179-11-6
WeightAverage: 477.038
Monoisotopic: 476.223056017
Chemical FormulaC29H33ClN2O2
InChI KeyRDOIQAHITMMDAJ-UHFFFAOYSA-N
InChI
InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
IUPAC Name
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
SMILES
CN(C)C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1=CC=CC=C1)C1=CC=CC=C1
Pharmacology
IndicationFor the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
Structured Indications
PharmacodynamicsLoperamide is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Loperamide is also indicated for reducing the volume of discharge from ileostomies. In man, Loperamide prolongs the transit time of the intestinal contents. It reduces the daily fecal volume, increases the viscosity and bulk density, and diminishes the loss of fluid and electrolytes. Tolerance to the antidiarrheal effect has not been observed. Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids. It works specifically by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.
Mechanism of actionIn vitro and animal studies show that Loperamide acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Loperamide inhibits peristaltic activity by a direct effect on the circular and longitudinal muscles of the intestinal wall. It is a non-selective calcium channel blocker and binds to opioid mu-receptors. Evidence also suggests that at higher concentrations it binds to calmodulin.
TargetKindPharmacological actionActionsOrganismUniProt ID
Mu-type opioid receptorProteinyes
agonist
HumanP35372 details
Delta-type opioid receptorProteinyes
agonist
HumanP41143 details
Kappa-type opioid receptorProteinyes
agonist
HumanP41145 details
Voltage-dependent P/Q-type calcium channel subunit alpha-1AProteinunknown
inhibitor
HumanO00555 details
Pro-opiomelanocortinProteinunknown
modulator
HumanP01189 details
CalmodulinProteinunknown
inhibitor
HumanP62158 details
Related Articles
AbsorptionNot significantly absorbed from the gut
Volume of distributionNot Available
Protein binding97%
Metabolism

Hepatic

Route of eliminationExcretion of the unchanged loperamide and its metabolites mainly occurs through the feces.
Half life9.1 to 14.4 hours (average 10.8 hours)
ClearanceNot Available
ToxicityOral, mouse: LD50 = 105 mg/kg. Symptoms of overdose include constipation, drowsiness, lethargy, and nausea.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbirateroneThe serum concentration of Loperamide can be increased when it is combined with Abiraterone.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Loperamide.Approved
AcetaminophenThe serum concentration of Loperamide can be increased when it is combined with Acetaminophen.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Loperamide.Approved, Vet Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Loperamide.Approved
AlbendazoleThe serum concentration of Loperamide can be increased when it is combined with Albendazole.Approved, Vet Approved
AldosteroneThe serum concentration of Loperamide can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Loperamide can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Loperamide can be increased when it is combined with Alfentanil.Approved, Illicit
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Loperamide.Approved, Investigational
AmantadineThe serum concentration of Loperamide can be increased when it is combined with Amantadine.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Loperamide.Approved, Investigational
Aminohippuric acidThe serum concentration of Loperamide can be increased when it is combined with Aminohippuric acid.Approved
AmiodaroneThe metabolism of Loperamide can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Loperamide.Approved
AmlodipineThe serum concentration of Loperamide can be increased when it is combined with Amlodipine.Approved
AmprenavirThe serum concentration of Loperamide can be decreased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Loperamide can be increased when it is combined with Amsacrine.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Loperamide.Approved
AprepitantThe serum concentration of Loperamide can be increased when it is combined with Aprepitant.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Loperamide.Approved, Investigational
ArtemetherThe metabolism of Loperamide can be decreased when combined with Artemether.Approved
AstemizoleThe serum concentration of Loperamide can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe metabolism of Loperamide can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Loperamide can be increased when it is combined with Atenolol.Approved
AtomoxetineThe metabolism of Loperamide can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Loperamide can be increased when it is combined with Atorvastatin.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Loperamide.Approved, Investigational
AzelastineThe serum concentration of Loperamide can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Loperamide can be increased when it is combined with Azithromycin.Approved
BenzocaineThe serum concentration of Loperamide can be increased when it is combined with Benzocaine.Approved
BepridilThe serum concentration of Loperamide can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Loperamide.Approved, Vet Approved
BetaxololThe metabolism of Loperamide can be decreased when combined with Betaxolol.Approved
BexaroteneThe serum concentration of Loperamide can be decreased when it is combined with Bexarotene.Approved, Investigational
BiperidenThe serum concentration of Loperamide can be increased when it is combined with Biperiden.Approved
BoceprevirThe metabolism of Loperamide can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Loperamide can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Loperamide can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Loperamide.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Loperamide.Approved
BromocriptineThe serum concentration of Loperamide can be increased when it is combined with Bromocriptine.Approved, Investigational
BuprenorphineThe serum concentration of Loperamide can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Loperamide can be decreased when combined with Bupropion.Approved
BuspironeThe serum concentration of Loperamide can be increased when it is combined with Buspirone.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Loperamide.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Loperamide.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Loperamide.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Loperamide.Approved
CandesartanThe serum concentration of Loperamide can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Loperamide can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Loperamide can be increased when combined with Carbamazepine.Approved, Investigational
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Loperamide.Approved
CarvedilolThe serum concentration of Loperamide can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Loperamide can be increased when it is combined with Caspofungin.Approved
CelecoxibThe metabolism of Loperamide can be decreased when combined with Celecoxib.Approved, Investigational
CeritinibThe serum concentration of Loperamide can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Loperamide.Withdrawn
ChloroquineThe serum concentration of Loperamide can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorpromazineThe serum concentration of Loperamide can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Loperamide can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Loperamide can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
CholecalciferolThe metabolism of Loperamide can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CholesterolThe serum concentration of Loperamide can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Loperamide can be decreased when it is combined with Cholic Acid.Approved
CilazaprilThe serum concentration of Loperamide can be increased when it is combined with Cilazapril.Approved
CimetidineThe serum concentration of Loperamide can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Loperamide can be decreased when combined with Cinacalcet.Approved
CiprofloxacinThe serum concentration of Loperamide can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Loperamide.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Loperamide.Approved
ClarithromycinThe metabolism of Loperamide can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Loperamide can be decreased when combined with Clemastine.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Loperamide.Approved, Illicit
ClofazimineThe serum concentration of Loperamide can be increased when it is combined with Clofazimine.Approved, Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Loperamide.Approved, Investigational
ClomipramineThe serum concentration of Loperamide can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Loperamide.Approved
ClopidogrelThe metabolism of Loperamide can be decreased when combined with Clopidogrel.Approved, Nutraceutical
ClotrimazoleThe metabolism of Loperamide can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Loperamide.Approved
CobicistatThe serum concentration of Loperamide can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Loperamide.Approved
CocaineThe metabolism of Loperamide can be decreased when combined with Cocaine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Loperamide.Approved
ColforsinThe serum concentration of Loperamide can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Loperamide can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Loperamide.Approved
CrizotinibThe metabolism of Loperamide can be decreased when combined with Crizotinib.Approved
CyclophosphamideThe serum concentration of Loperamide can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe metabolism of Loperamide can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Loperamide.Approved
DabrafenibThe serum concentration of Loperamide can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Loperamide can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Loperamide can be increased when it is combined with Dactinomycin.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Loperamide.Approved
DarifenacinThe metabolism of Loperamide can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Loperamide can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Loperamide can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Loperamide can be decreased when it is combined with Daunorubicin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Loperamide.Approved
DeferasiroxThe serum concentration of Loperamide can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Loperamide can be decreased when combined with Delavirdine.Approved
DesipramineThe serum concentration of Loperamide can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Loperamide can be increased when it is combined with Desloratadine.Approved, Investigational
DexamethasoneThe serum concentration of Loperamide can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Loperamide can be increased when it is combined with Dextromethorphan.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Loperamide.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Loperamide can be increased when it is combined with Diclofenac.Approved, Vet Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Loperamide.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Loperamide.Approved
DigoxinThe serum concentration of Loperamide can be decreased when it is combined with Digoxin.Approved
DihydroergotamineThe metabolism of Loperamide can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Loperamide.Illicit
DiltiazemThe metabolism of Loperamide can be decreased when combined with Diltiazem.Approved
DiphenhydramineThe metabolism of Loperamide can be decreased when combined with Diphenhydramine.Approved
DipyridamoleThe serum concentration of Loperamide can be increased when it is combined with Dipyridamole.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Loperamide.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Loperamide.Approved, Investigational, Vet Approved
DoxazosinThe serum concentration of Loperamide can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Loperamide can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Loperamide.Approved, Investigational
DoxorubicinThe serum concentration of Loperamide can be decreased when it is combined with Doxorubicin.Approved, Investigational
DoxycyclineThe metabolism of Loperamide can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Loperamide can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe metabolism of Loperamide can be decreased when combined with Dronedarone.Approved
DuloxetineThe metabolism of Loperamide can be decreased when combined with Duloxetine.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Loperamide.Approved
EfavirenzThe serum concentration of Loperamide can be decreased when it is combined with Efavirenz.Approved, Investigational
ElbasvirThe serum concentration of Loperamide can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Loperamide.Approved, Investigational
EliglustatThe metabolism of Loperamide can be decreased when combined with Eliglustat.Approved
EnalaprilThe serum concentration of Loperamide can be increased when it is combined with Enalapril.Approved, Vet Approved
EnzalutamideThe serum concentration of Loperamide can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Loperamide.Approved, Investigational
ErgonovineThe serum concentration of Loperamide can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Loperamide can be increased when it is combined with Ergotamine.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Loperamide.Approved, Investigational
ErythromycinThe metabolism of Loperamide can be decreased when combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of Loperamide can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Loperamide.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Loperamide can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Loperamide can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Loperamide can be decreased when it is combined with Estrone.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Loperamide.Approved
EtoposideThe serum concentration of Loperamide can be increased when it is combined with Etoposide.Approved
EtravirineThe serum concentration of Loperamide can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Loperamide.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Loperamide.Approved
FelodipineThe serum concentration of Loperamide can be increased when it is combined with Felodipine.Approved, Investigational
FentanylThe serum concentration of Loperamide can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Loperamide.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Loperamide.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Loperamide.Approved
FluconazoleThe metabolism of Loperamide can be decreased when combined with Fluconazole.Approved
FluoxetineThe metabolism of Loperamide can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Loperamide can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Loperamide can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Loperamide can be increased when it is combined with Flurazepam.Approved, Illicit
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Loperamide.Approved
FluvoxamineThe metabolism of Loperamide can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Loperamide can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Loperamide can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Loperamide can be increased when combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Loperamide can be increased when it is combined with Fusidic Acid.Approved
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Loperamide.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Loperamide.Approved
GemfibrozilThe metabolism of Loperamide can be decreased when combined with Gemfibrozil.Approved
GenisteinThe serum concentration of Loperamide can be increased when it is combined with Genistein.Investigational
GlyburideThe serum concentration of Loperamide can be increased when it is combined with Glyburide.Approved
GlycerolThe serum concentration of Loperamide can be increased when it is combined with Glycerol.Experimental
Gramicidin DThe serum concentration of Loperamide can be increased when it is combined with Gramicidin D.Approved
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Loperamide.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Loperamide.Withdrawn
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Loperamide.Approved
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Loperamide.Approved, Vet Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Loperamide.Approved
IdelalisibThe serum concentration of Loperamide can be increased when it is combined with Idelalisib.Approved
ImatinibThe metabolism of Loperamide can be decreased when combined with Imatinib.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Loperamide.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Loperamide.Approved
IndinavirThe metabolism of Loperamide can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Loperamide can be increased when it is combined with Indomethacin.Approved, Investigational
IrbesartanThe metabolism of Loperamide can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Loperamide.Approved, Investigational
IsavuconazoniumThe metabolism of Loperamide can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoniazidThe metabolism of Loperamide can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Loperamide can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Loperamide can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Loperamide can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Loperamide.Approved, Vet Approved
KetamineThe serum concentration of Loperamide can be increased when it is combined with Ketamine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Loperamide.Approved
KetoconazoleThe metabolism of Loperamide can be decreased when combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Loperamide.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Loperamide.Approved, Investigational
LansoprazoleThe serum concentration of Loperamide can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Loperamide can be increased when it is combined with Lapatinib.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Loperamide.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Loperamide.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Loperamide.Approved
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Loperamide.Approved, Investigational
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Loperamide.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Loperamide.Approved
LevothyroxineThe serum concentration of Loperamide can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Loperamide can be increased when it is combined with Lidocaine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Loperamide.Approved
LiothyronineThe serum concentration of Loperamide can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Loperamide can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Loperamide can be increased when it is combined with Lisinopril.Approved, Investigational
LomitapideThe serum concentration of Loperamide can be increased when it is combined with Lomitapide.Approved
LopinavirThe metabolism of Loperamide can be decreased when combined with Lopinavir.Approved
LoratadineThe serum concentration of Loperamide can be increased when it is combined with Loratadine.Approved
LorcaserinThe metabolism of Loperamide can be decreased when combined with Lorcaserin.Approved
LosartanThe serum concentration of Loperamide can be increased when it is combined with Losartan.Approved
LovastatinThe metabolism of Loperamide can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Loperamide can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Loperamide can be increased when it is combined with Lumacaftor.Approved
LumefantrineThe metabolism of Loperamide can be decreased when combined with Lumefantrine.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Loperamide.Approved, Investigational
MaprotilineThe serum concentration of Loperamide can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Loperamide can be increased when it is combined with Mebendazole.Approved, Vet Approved
MefloquineThe serum concentration of Loperamide can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Loperamide can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MeprobamateThe serum concentration of Loperamide can be increased when it is combined with Meprobamate.Approved, Illicit
MethadoneThe serum concentration of Loperamide can be increased when it is combined with Methadone.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Loperamide.Approved
MethotrimeprazineThe metabolism of Loperamide can be decreased when combined with Methotrimeprazine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Loperamide.Approved, Vet Approved
MetoprololThe serum concentration of Loperamide can be increased when it is combined with Metoprolol.Approved, Investigational
MibefradilThe serum concentration of Loperamide can be increased when it is combined with Mibefradil.Withdrawn
MiconazoleThe serum concentration of Loperamide can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Loperamide can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Loperamide can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Loperamide.Approved
MitomycinThe serum concentration of Loperamide can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Loperamide can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Loperamide can be decreased when it is combined with Mitoxantrone.Approved, Investigational
ModafinilThe serum concentration of Loperamide can be decreased when it is combined with Modafinil.Approved, Investigational
MorphineThe serum concentration of Morphine can be increased when it is combined with Loperamide.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Loperamide.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Loperamide.Approved
NafcillinThe serum concentration of Loperamide can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Loperamide.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Loperamide.Approved, Vet Approved
NaltrexoneThe serum concentration of Loperamide can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Loperamide can be increased when it is combined with Naringenin.Experimental
NefazodoneThe metabolism of Loperamide can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Loperamide can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Loperamide can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Loperamide can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Loperamide can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Loperamide can be increased when it is combined with Nicardipine.Approved
NifedipineThe serum concentration of Loperamide can be decreased when it is combined with Nifedipine.Approved
NilotinibThe metabolism of Loperamide can be decreased when combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Loperamide.Approved
NisoldipineThe serum concentration of Loperamide can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Loperamide can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Loperamide can be increased when it is combined with Nitrendipine.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Loperamide.Approved
NorethisteroneThe serum concentration of Loperamide can be decreased when it is combined with Norethisterone.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Loperamide.Approved, Investigational
OlaparibThe metabolism of Loperamide can be decreased when combined with Olaparib.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Loperamide.Approved
OmeprazoleThe serum concentration of Loperamide can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OsimertinibThe serum concentration of Loperamide can be increased when it is combined with Osimertinib.Approved
P-NitrophenolThe serum concentration of Loperamide can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Loperamide can be increased when it is combined with Paclitaxel.Approved, Vet Approved
PalbociclibThe serum concentration of Loperamide can be increased when it is combined with Palbociclib.Approved
Palmitic AcidThe serum concentration of Loperamide can be increased when it is combined with Palmitic Acid.Experimental
PanobinostatThe serum concentration of Loperamide can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe serum concentration of Loperamide can be increased when it is combined with Pantoprazole.Approved
ParoxetineThe metabolism of Loperamide can be decreased when combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Loperamide.Approved
Peginterferon alfa-2bThe serum concentration of Loperamide can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentobarbitalThe metabolism of Loperamide can be increased when combined with Pentobarbital.Approved, Vet Approved
PerindoprilThe serum concentration of Loperamide can be increased when it is combined with Perindopril.Approved
PhenobarbitalThe metabolism of Loperamide can be increased when combined with Phenobarbital.Approved
PhenytoinThe metabolism of Loperamide can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe serum concentration of Loperamide can be increased when it is combined with Pimozide.Approved
PioglitazoneThe metabolism of Loperamide can be decreased when combined with Pioglitazone.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Loperamide.Approved
Platelet Activating FactorThe serum concentration of Loperamide can be decreased when it is combined with Platelet Activating Factor.Experimental
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Loperamide.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Loperamide.Approved
PosaconazoleThe metabolism of Loperamide can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Loperamide.Approved
PrazosinThe serum concentration of Loperamide can be increased when it is combined with Prazosin.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Loperamide.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Loperamide.Approved, Vet Approved
PrimidoneThe metabolism of Loperamide can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Loperamide can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Loperamide can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromazineThe metabolism of Loperamide can be decreased when combined with Promazine.Approved, Vet Approved
PromethazineThe serum concentration of Loperamide can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Loperamide can be increased when it is combined with Propafenone.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Loperamide.Approved, Investigational
ProtriptylineThe serum concentration of Loperamide can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Loperamide.Approved
QuazepamThe serum concentration of Loperamide can be increased when it is combined with Quazepam.Approved, Illicit
QuercetinThe serum concentration of Loperamide can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Loperamide.Approved
QuinacrineThe serum concentration of Loperamide can be increased when it is combined with Quinacrine.Approved
QuinidineThe metabolism of Loperamide can be decreased when combined with Quinidine.Approved
QuinineThe serum concentration of Loperamide can be increased when it is combined with Quinine.Approved
RabeprazoleThe metabolism of Loperamide can be decreased when combined with Rabeprazole.Approved, Investigational
RamosetronLoperamide may increase the constipating activities of Ramosetron.Approved
RanitidineThe serum concentration of Loperamide can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Loperamide.Approved, Investigational
ReboxetineThe serum concentration of Loperamide can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Loperamide can be increased when it is combined with Regorafenib.Approved
ReserpineThe serum concentration of Loperamide can be decreased when it is combined with Reserpine.Approved
RifabutinThe metabolism of Loperamide can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Loperamide can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Loperamide can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Loperamide.Approved, Investigational
RilpivirineThe serum concentration of Loperamide can be increased when it is combined with Rilpivirine.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Loperamide.Approved, Investigational
RitonavirThe metabolism of Loperamide can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Loperamide.Approved
RolapitantThe serum concentration of Loperamide can be increased when it is combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Loperamide.Approved, Investigational
RopiniroleThe metabolism of Loperamide can be decreased when combined with Ropinirole.Approved, Investigational
RosiglitazoneThe metabolism of Loperamide can be decreased when combined with Rosiglitazone.Approved, Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Loperamide.Approved, Vet Approved
SaquinavirThe metabolism of Loperamide can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe serum concentration of Loperamide can be increased when it is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Loperamide can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe serum concentration of Loperamide can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Loperamide.Approved
SertralineThe serum concentration of Loperamide can be increased when it is combined with Sertraline.Approved
SildenafilThe metabolism of Loperamide can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Loperamide.Approved
SiltuximabThe serum concentration of Loperamide can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Loperamide can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Loperamide can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Loperamide can be decreased when it is combined with Sirolimus.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Loperamide.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Loperamide.Approved
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Loperamide.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Loperamide.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Loperamide.Experimental
SpironolactoneThe serum concentration of Loperamide can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Loperamide can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Loperamide can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Loperamide can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Loperamide can be decreased when it is combined with Streptozocin.Approved
SulfamethoxazoleThe metabolism of Loperamide can be decreased when combined with Sulfamethoxazole.Approved
SulfinpyrazoneThe serum concentration of Loperamide can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleThe metabolism of Loperamide can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Loperamide can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Loperamide can be increased when it is combined with Sunitinib.Approved, Investigational
TacrineThe serum concentration of Loperamide can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Loperamide can be decreased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of Loperamide can be decreased when it is combined with Tamoxifen.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Loperamide.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Loperamide.Approved
TelaprevirThe metabolism of Loperamide can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Loperamide can be decreased when combined with Telithromycin.Approved
TelmisartanThe serum concentration of Loperamide can be increased when it is combined with Telmisartan.Approved, Investigational
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Loperamide.Approved
TerazosinThe serum concentration of Loperamide can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Loperamide can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Loperamide can be increased when it is combined with Terfenadine.Withdrawn
TeriflunomideThe metabolism of Loperamide can be decreased when combined with Teriflunomide.Approved
TesmilifeneThe serum concentration of Loperamide can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Loperamide can be increased when it is combined with Testosterone.Approved, Investigational
ThioridazineThe metabolism of Loperamide can be decreased when combined with Thioridazine.Approved
ThiotepaThe metabolism of Loperamide can be decreased when combined with Thiotepa.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Loperamide.Approved
TiclopidineThe metabolism of Loperamide can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Loperamide.Approved
TipranavirThe metabolism of Loperamide can be decreased when combined with Tipranavir.Approved, Investigational
TocilizumabThe serum concentration of Loperamide can be decreased when it is combined with Tocilizumab.Approved
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Loperamide.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Loperamide.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Loperamide.Approved, Investigational
TranylcypromineThe metabolism of Loperamide can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Loperamide.Approved
TrazodoneThe serum concentration of Loperamide can be decreased when it is combined with Trazodone.Approved, Investigational
TrifluoperazineThe serum concentration of Loperamide can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Loperamide can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Loperamide can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Loperamide can be increased when it is combined with Trimipramine.Approved
TroleandomycinThe serum concentration of Loperamide can be increased when it is combined with Troleandomycin.Approved
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Loperamide.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Loperamide.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Loperamide.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Loperamide.Approved
VenlafaxineThe metabolism of Loperamide can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Loperamide can be decreased when combined with Verapamil.Approved
VinblastineThe serum concentration of Loperamide can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Loperamide.Approved, Investigational
VincristineThe serum concentration of Loperamide can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Loperamide can be increased when it is combined with Vinorelbine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Loperamide.Approved
VoriconazoleThe metabolism of Loperamide can be decreased when combined with Voriconazole.Approved, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Loperamide.Approved
ZimelidineThe serum concentration of Loperamide can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Loperamide can be decreased when combined with Ziprasidone.Approved
Food Interactions
  • Take without regard to meals. Increase liquid intake.
References
Synthesis Reference

Tsutomu Awamura, Hisanobu Nishikawa, Toshio Inagi, “FILM PREPARATION CONTAINING LOPERAMIDE HYDROCHLORIDE.” U.S. Patent US20110159058, issued June 30, 2011.

US20110159058
General ReferencesNot Available
External Links
ATC CodesA07DA53A07DA03A07DA05
AHFS Codes
  • 56:08.00
PDB EntriesNot Available
FDA labelDownload (55.5 KB)
MSDSDownload (73.8 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9878
Blood Brain Barrier+0.7709
Caco-2 permeable+0.5875
P-glycoprotein substrateSubstrate0.7476
P-glycoprotein inhibitor IInhibitor0.8277
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterInhibitor0.5059
CYP450 2C9 substrateNon-substrate0.8057
CYP450 2D6 substrateNon-substrate0.5315
CYP450 3A4 substrateSubstrate0.7918
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9154
CYP450 2D6 inhibitorInhibitor0.8933
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9207
Ames testNon AMES toxic0.768
CarcinogenicityNon-carcinogens0.8564
BiodegradationNot ready biodegradable0.9953
Rat acute toxicity3.6560 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9461
hERG inhibition (predictor II)Inhibitor0.7639
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Mcneil consumer healthcare
  • Mcneil pediatrics
  • Janssen pharmaceutica products lp
Packagers
Dosage forms
FormRouteStrength
Capsule, liquid filledOral2 mg/1
TabletOral2 mg/1
SolutionOral.2 mg
LiquidOral1 mg/5mL
SolutionOral1 mg/5mL
Tablet, film coatedOral2 mg/1
SuspensionOral1 mg/7.5mL
SolutionOral1 mg/7.5mL
Tablet, coatedOral2 mg/1
SolutionOral2 mg
TabletOral
Tablet, chewableOral
CapsuleOral2 mg
LiquidOral.2 mg
CapsuleOral2 mg/1
LiquidOral1 mg/7.5mL
SolutionOral2 mg/10mL
TabletOral2 mg
SolutionOral0.2 mg
Prices
Unit descriptionCostUnit
Loperamide hcl powder26.01USD g
Loperamide HCl 2 mg capsule0.64USD capsule
Imodium a-d 2 mg caplet0.49USD caplet
Imodium advanced caplet0.46USD caplet
Imodium ms relief caplet0.46USD caplet
Kaopectate 262 mg caplet0.37USD caplet
Loperamide 2 mg caplet0.37USD caplet
Qc anti-diarrheal adv caplet0.3USD caplet
Diamode 2 mg tablet0.28USD tablet
Kaopectate 240 mg softgel0.25USD softgel capsule
Anti-diarrheal 2 mg caplet0.18USD caplet
CVS Pharmacy anti-diarrheal 2 mg caplet0.14USD caplet
Kaopectate children's suspension0.02USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2134611 No2002-12-242014-10-28Canada
US6103260 No1997-07-172017-07-17Us
US6814978 No2001-08-262021-08-26Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point222.1U.S. Patent 3,714,159; 3,884,916.
water solubilitySlightNot Available
logP5.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00086 mg/mLALOGPS
logP4.44ALOGPS
logP4.77ChemAxon
logS-5.7ALOGPS
pKa (Strongest Acidic)13.96ChemAxon
pKa (Strongest Basic)9.41ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area43.78 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity139.32 m3·mol-1ChemAxon
Polarizability52.67 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-004i-0000900000-673950710672b433271cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-014i-0090000000-4b7b347a8b8e9dca406cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-02t9-0090000000-31f15df976e23e73330aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-004i-0000900000-d91d13c4e4665bd5fb5aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-004i-0020900000-f1be3181a6918c985ffdView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-014i-0090000000-e5e41346303f41f65688View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-014i-0090000000-acd8b87c1338e5d0fe25View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-014i-0090000000-81b85f788d14641430fdView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-014i-0090000000-3ce1a89454d777268799View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-03di-0090000000-f101d63ad0bf8e5d2178View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Phenylpiperidine
  • Phenylacetamide
  • Phenylpropylamine
  • Aralkylamine
  • Halobenzene
  • Chlorobenzene
  • Piperidine
  • N-acyl-amine
  • Aryl halide
  • Aryl chloride
  • Tertiary carboxylic acid amide
  • Tertiary alcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. DeHaven-Hudkins DL, Burgos LC, Cassel JA, Daubert JD, DeHaven RN, Mansson E, Nagasaka H, Yu G, Yaksh T: Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J Pharmacol Exp Ther. 1999 Apr;289(1):494-502. [PubMed:10087042 ]
  2. Tan-No K, Niijima F, Nakagawasai O, Sato T, Satoh S, Tadano T: Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice. Eur J Pharm Sci. 2003 Nov;20(3):357-63. [PubMed:14592702 ]
  3. Roge J, Baumer P, Berard H, Schwartz JC, Lecomte JM: The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide. Scand J Gastroenterol. 1993 Apr;28(4):352-4. [PubMed:8488368 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  5. Giagnoni G, Casiraghi L, Senini R, Revel L, Parolaro D, Sala M, Gori E: Loperamide: evidence of interaction with mu and delta opioid receptors. Life Sci. 1983;33 Suppl 1:315-8. [PubMed:6319884 ]
  6. di Bosco AM, Grieco P, Diurno MV, Campiglia P, Novellino E, Mazzoni O: Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors. Chem Biol Drug Des. 2008 Apr;71(4):328-35. doi: 10.1111/j.1747-0285.2008.00637.x. Epub 2008 Feb 12. [PubMed:18284554 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurot...
Gene Name:
OPRD1
Uniprot ID:
P41143
Molecular Weight:
40368.235 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Giagnoni G, Casiraghi L, Senini R, Revel L, Parolaro D, Sala M, Gori E: Loperamide: evidence of interaction with mu and delta opioid receptors. Life Sci. 1983;33 Suppl 1:315-8. [PubMed:6319884 ]
  3. di Bosco AM, Grieco P, Diurno MV, Campiglia P, Novellino E, Mazzoni O: Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors. Chem Biol Drug Des. 2008 Apr;71(4):328-35. doi: 10.1111/j.1747-0285.2008.00637.x. Epub 2008 Feb 12. [PubMed:18284554 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates th...
Gene Name:
OPRK1
Uniprot ID:
P41145
Molecular Weight:
42644.665 Da
References
  1. DeHaven-Hudkins DL, Burgos LC, Cassel JA, Daubert JD, DeHaven RN, Mansson E, Nagasaka H, Yu G, Yaksh T: Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J Pharmacol Exp Ther. 1999 Apr;289(1):494-502. [PubMed:10087042 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to...
Gene Name:
CACNA1A
Uniprot ID:
O00555
Molecular Weight:
282362.39 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Church J, Fletcher EJ, Abdel-Hamid K, MacDonald JF: Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons. Mol Pharmacol. 1994 Apr;45(4):747-57. [PubMed:8183255 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
modulator
General Function:
Type 4 melanocortin receptor binding
Specific Function:
ACTH stimulates the adrenal glands to release cortisol.MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.Beta-endorphin and Met-enkephalin are endogenous opiates.
Gene Name:
POMC
Uniprot ID:
P01189
Molecular Weight:
29423.72 Da
References
  1. Nomura A, Iwasaki Y, Aoki Y, Yamamori E, Mutsuga N, Yoshida M, Asai M, Oiso Y, Saito H: Effects of loperamide and other opioid-related substances on the transcriptional regulation of the rat pro-opiomelanocortin gene in AtT20 cells. Neuroendocrinology. 2001 Aug;74(2):87-94. [PubMed:11474216 ]
  2. Auernhammer CJ, Stalla GK, Lange M, Pfeiffer A, Muller OA: Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro. J Clin Endocrinol Metab. 1992 Aug;75(2):552-7. [PubMed:1322429 ]
  3. Ambrosi B, Bochicchio D, Ferrario R, Colombo P, Faglia G: Effects of the opiate agonist loperamide on pituitary-adrenal function in patients with suspected hypercortisolism. J Endocrinol Invest. 1989 Jan;12(1):31-5. [PubMed:2545766 ]
  4. Ambrosi B, Bochicchio D, Colombo P, Ferrario R, Faglia G: Loperamide modifies but does not block the corticotropin-releasing hormone-induced ACTH response in patients with Addison's disease. Horm Metab Res Suppl. 1987;16:74-5. [PubMed:2832297 ]
  5. Bochicchio D, Ambrosi B, Faglia G: Loperamide, an opiate analog, differently modifies the adrenocorticotropin responses to corticotropin-releasing hormone and lysine vasopressin in patients with Addison's disease. Neuroendocrinology. 1988 Dec;48(6):611-4. [PubMed:2855105 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Titin binding
Specific Function:
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Gene Name:
CALM1
Uniprot ID:
P62158
Molecular Weight:
16837.47 Da
References
  1. Daly JW, Harper J: Loperamide: novel effects on capacitative calcium influx. Cell Mol Life Sci. 2000 Jan 20;57(1):149-57. [PubMed:10949586 ]
  2. Suzuki T, Sakai H, Ikari A, Takeguchi N: Inhibition of thromboxane A(2)-induced Cl(-) secretion by antidiarrhea drug loperamide in isolated rat colon. J Pharmacol Exp Ther. 2000 Oct;295(1):233-8. [PubMed:10991984 ]
  3. Mellstrand T: Loperamide--an opiate receptor agonist with gastrointestinal motility effects. Scand J Gastroenterol Suppl. 1987;130:65-6. [PubMed:2820051 ]
  4. Stoll R, Ruppin H, Domschke W: Calmodulin-mediated effects of loperamide on chloride transport by brush border membrane vesicles from human ileum. Gastroenterology. 1988 Jul;95(1):69-76. [PubMed:2836258 ]
  5. Diener M, Knobloch SF, Rummel W: Action of loperamide on neuronally mediated and Ca2+- or cAMP-mediated secretion in rat colon. Eur J Pharmacol. 1988 Aug 2;152(3):217-25. [PubMed:2851449 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Baker DE: Loperamide: a pharmacological review. Rev Gastroenterol Disord. 2007;7 Suppl 3:S11-8. [PubMed:18192961 ]
  2. Kim KA, Chung J, Jung DH, Park JY: Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. Epub 2004 Sep 8. [PubMed:15365656 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Kim KA, Chung J, Jung DH, Park JY: Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. Epub 2004 Sep 8. [PubMed:15365656 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Kim KA, Chung J, Jung DH, Park JY: Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. Epub 2004 Sep 8. [PubMed:15365656 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Kim KA, Chung J, Jung DH, Park JY: Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. Epub 2004 Sep 8. [PubMed:15365656 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wandel C, Kim R, Wood M, Wood A: Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology. 2002 Apr;96(4):913-20. [PubMed:11964599 ]
  2. Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. [PubMed:11785684 ]
  3. Schinkel AH, Wagenaar E, Mol CA, van Deemter L: P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest. 1996 Jun 1;97(11):2517-24. [PubMed:8647944 ]
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Drug created on June 13, 2005 07:24 / Updated on December 07, 2016 02:38