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Displaying drugs 126 - 150 of 8047 in total

Medrogestone

Medrogestone (INN), also known as 6,17α-dimethyl-6-dehydroprogesterone, is a progestational agent derived from 17-methylprogesterone. It was conceived as an alternative for an orally effective contraceptive option. It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing. It was never approved by the FDA.
Approved
Withdrawn
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Acetyl sulfisoxazole

Sulfisoxazole acetyl is an ester of sulfisoxazole, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, dihydropteroate synthase, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. This process causes...
Approved
Vet approved
Matched Description: … This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines ... of para-aminobenzoic acid (PABA) with antibacterial activity. ... PABA into dihydrofolic acid, which is the precursor of folic acid. …
Matched Categories: … combinations of sulfonamides …

Ribavirin

Producing a broad-spectrum activity against several RNA and DNA viruses, Ribavirin is a synthetic guanosine nucleoside and antiviral agent that interferes with the synthesis of viral mRNA. It is primarily indicated for use in treating hepatitis C and viral hemorrhagic fevers. HCV is a single-stranded RNA virus that is categorized...
Approved
Matched Description: … Combination therapy of ribavirin and [DB00008] results in the SVR of 44% in patients with genotype 1 ... Additionally, including ribavirin in the regimen can increase the risk of anemia. ... Ribavirin is a synthetic guanosine nucleoside and antiviral agent that interferes with the synthesis of …
Matched Categories: … Antivirals for treatment of HCV infections …

Butalbital

Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervous system (CNS) depression that ranges from...
Approved
Illicit
Matched Description: … [A177754] Butalbital has a low degree of selectivity and a narrow therapeutic index. ... Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens ... It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety …
Matched Categories: … combinations of barbiturates …

Diethylpropion

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
Approved
Illicit
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Ioxitalamic acid

Ioxitalamate is an ionic iodinated contrast medium. It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg. Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995. Until the...
Approved
Matched Description: … [A27209] It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of ... [A33006] Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem …
Matched Categories: … Diagnostic Uses of Chemicals …

Follitropin

Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78...
Approved
Matched Description: … Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural ... Follitropin is important in the development of follicles produced by the ovaries. ... Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Tryptophan

An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit...
Approved
Nutraceutical
Withdrawn
Matched Description: … It is a precursor of indole alkaloids in plants. ... It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Silver sulfadiazine

Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.
Approved
Vet approved
Matched Categories: … combinations of sulfonamides …

Gadoxetic acid

Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. Gadoxetate is a...
Approved
Matched Description: … contrast of enhancement and therefore heightening the liver parenchyma-liver tumours contrast. ... anion-transporting polypeptides (OATPs) and liver tumor cells lack OATPs, liver tumors show a lack of …
Matched Categories: … Diagnostic Uses of Chemicals …

Tedizolid phosphate

Drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus penumoniae, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved linezolid and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the...
Approved
Matched Description: … [A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the ... Tedizolid is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Milnacipran

Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the additional indication of...
Approved
Investigational
Matched Description: … robust evidence of efficacy, insufficient demonstration of maintenance of effect, and other concerns ... category was originally developed for and continues to be approved and indicated for the treatment of ... somewhat increased preference for noradrenaline reuptake inhibition - which is potentially a point of …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sumatriptan

Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. Sumatriptan was granted FDA approval on 28 December 1992.
Approved
Investigational
Matched Description: … [L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available …
Matched Categories: … combinations of sulfonamides ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Benzocaine

Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.
Approved
Investigational
Matched Description: … Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve …
Matched Mixtures name: … MK Sting Relief Pads …
Matched Categories: … Esters of Aminobenzoic Acid ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Sulfadoxine

A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.
Approved
Investigational
Matched Categories: … combinations of sulfonamides …

Estriol

A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is...
Approved
Investigational
Vet approved
Matched Description: … Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement ... During pregnancy, large amount of estriol is produced by the placenta. ... Isomers with inversion of the hydroxyl group or groups are called epiestriol. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Mafenide

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder...
Approved
Vet approved
Withdrawn
Matched Description: … It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep ... In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA …
Matched Categories: … combinations of sulfonamides …

Isatuximab

Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic antibody targeted against CD38, a glycoprotein found on the...
Approved
Investigational
Matched Description: … [L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains ... [L12099] It is a cytolytic antibody targeted against CD38, a glycoprotein found on the surface of some ... ] isatuximab was granted Orphan Drug designation and approved on March 2nd, 2020, for the treatment of …
Matched Categories: … CD38 (Clusters of Differentiation 38) inhibitors …

Cloxacillin

A semi-synthetic penicillin antibiotic which is a chlorinated derivative of oxacillin.
Approved
Investigational
Vet approved
Matched Description: … A semi-synthetic penicillin antibiotic which is a chlorinated derivative of [oxacillin]. …
Matched Categories: … combinations of penicillins …

Iopromide

Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can cause several serious adverse effects, including...
Approved
Matched Description: … It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, ... permitting radiographic visualization of the internal structures until significant hemodilution occurs ... intrathecally inadvertently, it is still deemed to have a favorable safety profile, with only 0.7% of …
Matched Categories: … Diagnostic Uses of Chemicals …

Pramocaine

Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications...
Approved
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Mephentermine

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra...
Approved
Matched Description: … Although the central stimulant effects of mephentermine are much less than those of amphetamine, its …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sulfamerazine

A sulfanilamide that is used as an antibacterial agent.
Approved
Vet approved
Matched Categories: … combinations of sulfonamides …

Gepirone

Gepirone, an azapirone, is a pharmacologic analog of buspirone that acts selectively on the pre- and post-synaptic 5HT1A receptors. Although earlier clinical trials showed promising results for gepirone, its formulation as an immediate-release tablet necessitates frequent administration due to the short half-lives. It was not until an extended-release formulation of...
Approved
Investigational
Matched Description: … side effects as that of the placebo. ... Gepirone, an azapirone, is a pharmacologic analog of [buspirone] that acts selectively on the pre- and ... It was not until an extended-release formulation of gepirone was made available that gepirone became …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Menotropins

Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women. It is used as a fertility medication that is injected either subcutaneously or intramuscularly. It is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with...
Approved
Matched Description: … Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of ... It is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Displaying drugs 126 - 150 of 8047 in total