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Identification
NameNaproxen
Accession NumberDB00788  (APRD01135, DB08298)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionAn anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
Structure
Thumb
Synonyms
(+)-(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid
(+)-(S)-Naproxen
(+)-2-(6-Methoxy-2-naphthyl)propionic acid
(+)-2-(Methoxy-2-naphthyl)-propionic acid
(+)-2-(Methoxy-2-naphthyl)-propionsäure
(+)-Naproxen
(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-(+)-Naproxen
(S)-2-(6-Methoxy-2-naphthyl)propanoic acid
(S)-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-Naproxen
Naprolag
Naproxen
Naproxène
Naproxeno
Naproxenum
External Identifiers
  • RS 3540
  • RS 3650
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AnaproxTablet275 mgOralAtnahs Pharma Uk Limited1995-12-31Not applicableCanada
AnaproxTablet275 mg/1OralGenentech, Inc.1980-09-04Not applicableUs
AnaproxTablet275 mgOralSyntex Inc.1980-12-311996-09-30Canada
Anaprox DSTablet550 mg/1OralCanton Laboratories2016-06-01Not applicableUs
Anaprox DSTablet550 mg/1OralGenentech, Inc.1980-09-04Not applicableUs
Anaprox DSTablet550 mgOralAtnahs Pharma Uk Limited1995-12-31Not applicableCanada
Anaprox DS Tab 550mgTablet550 mgOralSyntex Inc.1990-12-311996-09-30Canada
Ava-naproxen ECTablet, delayed release250 mgOralAvanstra Inc2011-10-112014-08-21Canada
Ava-naproxen ECTablet, delayed release500 mgOralAvanstra Inc2011-10-112014-08-21Canada
EC-naprosynTablet, delayed release500 mg/1OralGenentech, Inc.1994-10-14Not applicableUs
EC-naprosynTablet, delayed release375 mg/1OralCanton Laboratories2016-06-01Not applicableUs
EC-naprosynTablet, delayed release375 mg/1OralGenentech, Inc.1994-10-14Not applicableUs
EC-naprosynTablet, delayed release500 mg/1OralCanton Laboratories2016-06-01Not applicableUs
EC-naproxenTablet, delayed release375 mg/1OralCameron Pharmaceuticals, Llc2016-07-10Not applicableUs
EC-naproxenTablet, delayed release500 mg/1OralCameron Pharmaceuticals, Llc2016-07-10Not applicableUs
Mylan-naproxen ECTablet, delayed release375 mgOralMylan Pharmaceuticals Ulc2001-03-14Not applicableCanada
Mylan-naproxen ECTablet, delayed release500 mgOralMylan Pharmaceuticals Ulc1999-10-27Not applicableCanada
Mylan-naproxen ECTablet, delayed release250 mgOralMylan Pharmaceuticals Ulc2001-03-14Not applicableCanada
NaprelanTablet, film coated, extended release375 mg/1OralVictory Pharma, Inc.1996-01-052016-12-02Us
NaprelanTablet, film coated, extended release500 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-29Not applicableUs
NaprelanTablet, film coated, extended release375 mg/1OralALMATICA PHARMA INC.2014-01-17Not applicableUs
NaprelanTablet, film coated, extended release750 mg/1OralShionogi Inc.1996-04-01Not applicableUs
NaprelanTablet, film coated, extended release750 mg/1OralStat Rx USA2008-12-19Not applicableUs
NaprelanTablet, film coated, extended release750 mg/1OralVictory Pharma, Inc.2008-12-192016-12-02Us
NaprelanTablet, film coated, extended release750 mg/1OralPd Rx Pharmaceuticals, Inc.2008-12-19Not applicableUs
NaprelanTablet, film coated, extended release500 mg/1OralALMATICA PHARMA INC.2014-01-17Not applicableUs
NaprelanTablet, film coated, extended release500 mg/1OralShionogi Inc.1996-04-01Not applicableUs
NaprelanTablet, film coated, extended release375 mg/1OralRebel Distributors Corp1996-01-05Not applicableUs
NaprelanTablet, extended release375 mgOralAlkermes Inc2007-05-25Not applicableCanada
NaprelanTablet, film coated, extended release500 mg/1OralVictory Pharma, Inc.1996-01-052016-12-02Us
NaprelanTablet, film coated, extended release375 mg/1OralPhysicians Total Care, Inc.2005-08-19Not applicableUs
NaprelanTablet, film coated, extended release750 mg/1OralALMATICA PHARMA INC.2014-01-17Not applicableUs
NaprelanTablet, film coated, extended release375 mg/1Oralbryant ranch prepack1996-01-05Not applicableUs
NaprelanTablet, film coated, extended release500 mg/1OralRebel Distributors Corp1996-01-05Not applicableUs
NaprelanTablet, extended release500 mgOralAlkermes Inc2007-05-25Not applicableCanada
NaprelanKitOralVictory Pharma, Inc.2009-10-152016-12-02Us
NaprelanTablet, film coated, extended release375 mg/1OralShionogi Inc.1996-04-01Not applicableUs
NaprosynSuspension125 mg/5mLOralGenentech, Inc.1987-03-232016-05-31Us
NaprosynTablet375 mg/1OralGenentech, Inc.1976-03-112016-10-31Us
NaprosynTablet, extended release750 mgOralAtnahs Pharma Uk Limited1995-12-31Not applicableCanada
NaprosynTablet500 mg/1OralCanton Laboratories2016-06-01Not applicableUs
NaprosynTablet500 mg/1OralA S Medication Solutions Llc1976-03-11Not applicableUs
NaprosynTablet500 mg/1OralGenentech, Inc.1976-03-11Not applicableUs
NaprosynTablet, delayed release500 mgOralAtnahs Pharma Uk Limited1995-12-31Not applicableCanada
NaprosynTablet, delayed release375 mgOralAtnahs Pharma Uk Limited1995-12-31Not applicableCanada
NaprosynSuspension125 mg/5mLOralCanton Laboratories2016-05-20Not applicableUs
NaprosynTablet250 mg/1OralGenentech, Inc.1976-03-112016-11-30Us
Naprosyn 250mgTablet250 mgOralSyntex Inc.1975-12-311996-09-30Canada
Naprosyn 250mg TabletsTablet250 mgOralHoffmann La Roche Limited1995-12-312002-01-22Canada
Naprosyn 375mgTablet375 mgOralSyntex Inc.1983-12-311996-09-30Canada
Naprosyn 375mg TabletsTablet375 mgOralHoffmann La Roche Limited1996-12-312001-06-27Canada
Naprosyn 500 Mg SuppositoriesSuppository500 mgRectalHoffmann La Roche Limited1996-12-312002-11-18Canada
Naprosyn 500 Mg TabletsTablet500 mgOralHoffmann La Roche Limited1996-12-312002-07-09Canada
Naprosyn E 250mg Tablets - EctTablet, delayed release250 mgOralHoffmann La Roche Limited1995-12-312014-02-05Canada
Naprosyn E Tab 250mgTablet, delayed release250 mgOralSyntex Inc.1992-12-311996-09-30Canada
Naprosyn E Tab 375mgTablet, delayed release375 mgOralSyntex Inc.1992-12-311996-09-30Canada
Naprosyn E Tab 500mgTablet, delayed release500 mgOralSyntex Inc.1992-12-311996-09-30Canada
Naprosyn Sup 500mgSuppository500 mgRectalSyntex Inc.1984-12-311996-09-30Canada
Naprosyn Sus 25mg/mlSuspension25 mgOralSyntex Inc.1989-12-311996-09-30Canada
Naprosyn-SR Tab 750mgTablet, extended release750 mgOralSyntex Inc.1989-12-311996-09-30Canada
NaproxenSuspension125 mg/5mLOralKey Therapeutics, Llc2016-11-11Not applicableUs
NaproxenTablet250 mg/1OralCameron Pharmaceuticals, Llc2016-07-10Not applicableUs
NaproxenTablet250 mgOralSanis Health Inc2010-06-15Not applicableCanada
NaproxenTablet375 mg/1OralCameron Pharmaceuticals, Llc2016-07-10Not applicableUs
NaproxenTablet375 mgOralSanis Health Inc2010-06-15Not applicableCanada
NaproxenTablet500 mg/1OralCameron Pharmaceuticals, Llc2016-07-10Not applicableUs
NaproxenTablet500 mgOralSanis Health Inc2010-06-15Not applicableCanada
Naproxen 125 Tab 125mgTablet125 mgOralPro Doc Limitee1983-12-312009-07-23Canada
Naproxen 250 Tab 250mgTablet250 mgOralPro Doc Limitee1983-12-31Not applicableCanada
Naproxen 500 Tab 500mgTablet500 mgOralPro Doc Limitee1984-12-31Not applicableCanada
Naproxen ECTablet, delayed release250 mgOralSanis Health Inc2010-06-15Not applicableCanada
Naproxen ECTablet, delayed release375 mgOralSanis Health Inc2010-06-15Not applicableCanada
Naproxen ECTablet, delayed release500 mgOralSanis Health Inc2010-06-15Not applicableCanada
Naproxen SodiumTablet275 mgOralSanis Health Inc2010-06-15Not applicableCanada
Naproxen SodiumTablet275 mg/1OralCameron Pharmaceuticals, Llc2016-07-10Not applicableUs
Naproxen SodiumTablet, film coated, extended release750 mg/1OralAlvogen Inc.2015-03-11Not applicableUs
Naproxen SodiumTablet, film coated, extended release375 mg/1OralAlvogen Inc.2015-03-11Not applicableUs
Naproxen SodiumTablet, film coated, extended release500 mg/1OralAlvogen Inc.2015-03-11Not applicableUs
Naproxen Sodium DSTablet550 mgOralSanis Health Inc2010-06-15Not applicableCanada
Naproxen Sodium DSTablet550 mg/1OralCameron Pharmaceuticals, Llc2016-07-10Not applicableUs
Naproxen-375 Tab 375mgTablet375 mgOralPro Doc Limitee1985-12-31Not applicableCanada
Naproxen-NA Df -tab 550mgTablet550 mgOralPro Doc Limitee1999-09-15Not applicableCanada
Naproxen-NA Tab 275mgTablet275 mgOralPro Doc Limitee1995-12-31Not applicableCanada
Novo-naprox Tab 125mgTablet125 mgOralNovopharm Limited1982-12-312005-08-10Canada
Ntp-naproxenTablet500 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxenTablet250 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxenTablet375 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxen ECTablet, delayed release250 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxen ECTablet, delayed release375 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxen ECTablet, delayed release500 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxen SodiumTablet275 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxen Sodium DSTablet550 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Nu-napro-NATablet275 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-napro-NA DSTablet550 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-naprox ECTablet, delayed release250 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-naprox ECTablet, delayed release375 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-naprox ECTablet, delayed release500 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-naprox Tab 125mgTablet125 mgOralNu Pharm Inc1990-12-312012-09-04Canada
Nu-naprox Tab 250mgTablet250 mgOralNu Pharm Inc1990-12-312012-09-04Canada
Nu-naprox Tab 375mgTablet375 mgOralNu Pharm Inc1990-12-312012-09-04Canada
Nu-naprox Tab 500mgTablet500 mgOralNu Pharm Inc1990-12-312012-09-04Canada
Pediapharm Naproxen SuspensionSuspension25 mgOralPediapharm Inc1996-12-31Not applicableCanada
PMS-naproxenSuppository500 mgRectalPharmascience Inc1993-12-31Not applicableCanada
PMS-naproxen ECTablet, delayed release375 mgOralPharmascience Inc2007-10-01Not applicableCanada
PMS-naproxen ECTablet, delayed release500 mgOralPharmascience Inc2007-10-01Not applicableCanada
Pro-naproxen EC - 375Tablet, delayed release375 mgOralPro Doc Limitee2009-10-16Not applicableCanada
Pro-naproxen EC - 500Tablet, delayed release500 mgOralPro Doc Limitee2008-07-04Not applicableCanada
Ratio-naproxenTablet250 mgOralRatiopharm Inc Division Of Teva Canada Limited1984-12-312006-08-04Canada
Ratio-naproxenSuppository500 mgRectalRatiopharm Inc Division Of Teva Canada Limited1993-12-312006-08-04Canada
Ratio-naproxenTablet375 mgOralRatiopharm Inc Division Of Teva Canada Limited1984-12-312006-08-04Canada
Ratio-naproxenTablet500 mgOralRatiopharm Inc Division Of Teva Canada Limited1984-12-312006-08-04Canada
Ratio-naproxen ETablet, delayed release375 mgOralRatiopharm Inc Division Of Teva Canada LimitedNot applicableNot applicableCanada
Ratio-naproxen ETablet, delayed release500 mgOralRatiopharm Inc Division Of Teva Canada LimitedNot applicableNot applicableCanada
Ratio-naproxen ETablet, delayed release250 mgOralRatiopharm Inc Division Of Teva Canada LimitedNot applicableNot applicableCanada
Rhodiaprox - 500mg/supSuppository500 mgRectalRhodiapharm Inc1997-11-032000-07-28Canada
Riva-naproxenTablet250 mgOralLaboratoire Riva Inc1999-09-012013-07-31Canada
Riva-naproxenTablet375 mgOralLaboratoire Riva Inc1999-09-012013-07-31Canada
Riva-naproxenTablet500 mgOralLaboratoire Riva Inc1999-09-012013-07-31Canada
Riva-naproxen SodiumTablet275 mgOralLaboratoire Riva Inc2005-07-052013-07-31Canada
Riva-naproxen Sodium DSTablet550 mgOralLaboratoire Riva Inc2005-07-052013-07-31Canada
Sab-naproxenSuppository500 mgRectalSabex Inc1997-09-052008-08-07Canada
Synflex DS Tab 550mgTablet550 mgOralAltimed Pharma Inc.1993-12-312005-05-27Canada
Synflex Tab 275mgTablet275 mgOralAltimed Pharma Inc.1988-12-312005-05-27Canada
Teva-naproxenTablet250 mgOralTeva Canada Limited1982-12-31Not applicableCanada
Teva-naproxenTablet500 mgOralTeva Canada Limited1983-12-31Not applicableCanada
Teva-naproxenTablet375 mgOralTeva Canada Limited1984-12-31Not applicableCanada
Teva-naproxen ECTablet, delayed release250 mgOralTeva Canada Limited2001-04-02Not applicableCanada
Teva-naproxen ECTablet, delayed release375 mgOralTeva Canada Limited2001-04-02Not applicableCanada
Teva-naproxen ECTablet, delayed release500 mgOralTeva Canada Limited2001-04-02Not applicableCanada
Teva-naproxen SodiumTablet275 mgOralTeva Canada Limited1988-12-31Not applicableCanada
Teva-naproxen Sodium DSTablet550 mgOralTeva Canada Limited1993-12-31Not applicableCanada
Teva-naproxen SRTablet, extended release750 mgOralTeva Canada Limited2000-03-012015-12-04Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
All Day ReliefTablet220 mg/1OralREMEDYREPACK INC.2015-03-09Not applicableUs
AnaproxTablet550 mg/1OralDIRECT RX2016-07-11Not applicableUs
Apo Naproxen Tab 125mgTablet125 mgOralApotex Inc1982-12-31Not applicableCanada
Apo Naproxen Tab 250mgTablet250 mgOralApotex Inc1982-12-31Not applicableCanada
Apo Naproxen Tab 375mgTablet375 mgOralApotex Inc1983-12-31Not applicableCanada
Apo Naproxen Tab 500mgTablet500 mgOralApotex Inc1983-12-31Not applicableCanada
Apo-napro-NA DS Tab 550mgTablet550 mgOralApotex Inc1993-12-31Not applicableCanada
Apo-napro-NA Tab 275mgTablet275 mgOralApotex Inc1989-12-31Not applicableCanada
Apo-naproxen EC TabletsTablet, delayed release250 mgOralApotex Inc2003-04-23Not applicableCanada
Apo-naproxen EC TabletsTablet, delayed release375 mgOralApotex Inc2003-04-23Not applicableCanada
Apo-naproxen EC TabletsTablet, delayed release500 mgOralApotex Inc2003-04-23Not applicableCanada
Apo-naproxen SR Tablets 750mgTablet, extended release750 mgOralApotex Inc1999-05-05Not applicableCanada
Comfort Pac With NaproxenKitPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
Flanax NaproxenTablet500 mg/1OralBelmora LLC2015-08-18Not applicableUs
Good Sense All Day Pain ReliefTablet, film coated220 mg/1Oralbryant ranch prepack1997-01-14Not applicableUs
NaprosynTablet250 mg/1Oralbryant ranch prepack2009-09-01Not applicableUs
NaproxenTablet500 mg/1OralApotheca Inc.2007-07-01Not applicableUs
NaproxenTablet375 mg/1OralClinical Solutions Wholesale2010-02-18Not applicableUs
NaproxenTablet250 mg/1OralRebel Distributors Corp2007-07-01Not applicableUs
NaproxenTablet375 mg/1OralProficient Rx LP2007-07-01Not applicableUs
NaproxenTablet250 mg/1OralAphena Pharma Solutions Tennessee, Llc2009-08-10Not applicableUs
NaproxenTablet375 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralKeltman Pharmaceuticals Inc.2009-04-27Not applicableUs
NaproxenTablet500 mg/1OralAv Kare, Inc.2013-09-26Not applicableUs
NaproxenCapsule500 mg/1OralTime Cap Laboratories2016-07-06Not applicableUs
NaproxenTablet375 mg/1OralLake Erie Medical DBA Quality Care Products LLC1993-12-22Not applicableUs
NaproxenTablet, delayed release375 mg/1OralCipla USA Inc.2016-07-05Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.Not applicableNot applicableUs
NaproxenTablet500 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-12-13Not applicableUs
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2013-05-15Not applicableUs
NaproxenTablet250 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralBlenheim Pharmacal, Inc.2010-09-15Not applicableUs
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2014-03-03Not applicableUs
NaproxenTablet250 mg/1OralMajor Pharmaceuticals2009-08-10Not applicableUs
NaproxenTablet500 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
NaproxenTablet500 mg/1OralRebel Distributors Corp.2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2015-12-23Not applicableUs
NaproxenTablet500 mg/1OralSTAT Rx USA LLC2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralContract Pharmacy Services Pa2010-03-19Not applicableUs
NaproxenTablet500 mg/1OralLake Erie Medical DBA Quality Care Products LLC2010-02-18Not applicableUs
NaproxenTablet250 mg/1OralWest Ward Pharmaceuticals Corp2004-01-14Not applicableUs
NaproxenTablet500 mg/1OralBiomes Pharmaceuticals2015-03-23Not applicableUs
NaproxenTablet375 mg/1OralA S Medication Solutions2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralExelan Pharmaceuticals, Inc.2016-06-10Not applicableUs
NaproxenTablet375 mg/1OralPreferred Pharmaceuticals Inc.2015-08-14Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2011-06-282016-10-13Us
NaproxenTablet, film coated550 mg/1OralWest ward Pharmaceutical Corp1996-05-14Not applicableUs
NaproxenTablet500 mg/1OralGlenmark Pharmaceuticals Inc., Usa2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralA S Medication Solutions2012-01-23Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2016-05-042016-11-02Us
NaproxenTablet500 mg/1OralCipla USA Inc.2016-07-05Not applicableUs
NaproxenTablet500 mg/1OralAv Pak2015-02-05Not applicableUs
NaproxenTablet375 mg/1OralMajor Pharmaceuticals2008-11-08Not applicableUs
NaproxenTablet375 mg/1OralCardinal Health2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralAidarex Pharmaceuticals LLC2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralDispensing Solutions, Inc.2012-02-01Not applicableUs
NaproxenTablet500 mg/500mgOralAlivio Medical Products, Llc2015-10-01Not applicableUs
NaproxenTablet250 mg/1OralClinical Solutions Wholesale, Llc1993-12-22Not applicableUs
NaproxenTablet250 mg/1OralREMEDYREPACK INC.2014-12-01Not applicableUs
NaproxenTablet250 mg/1OralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
NaproxenTablet, delayed release500 mg/1OralCarilion Materials Management1998-07-29Not applicableUs
NaproxenTablet500 mg/1OralA S Medication Solutions2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralRed Pharm Drug, Inc.2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralLake Erie Medical DBA Quality Care Products LLC2010-09-28Not applicableUs
NaproxenTablet500 mg/1OralLiberty Pharmaceuticals, Inc.2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralH.J. Harkins Company, Inc.2007-07-01Not applicableUs
NaproxenTablet375 mg/1OralMajor Pharmaceuticals2011-02-28Not applicableUs
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2013-01-102016-10-21Us
NaproxenTablet250 mg/1OralPd Rx Pharmaceuticals, Inc.2004-01-14Not applicableUs
NaproxenTablet500 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2010-02-18Not applicableUs
NaproxenTablet250 mg/1OralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralAmerican Health Packaging2013-09-30Not applicableUs
NaproxenTablet375 mg/1OralA S Medication Solutions2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-07-18Not applicableUs
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2013-05-15Not applicableUs
NaproxenTablet375 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralBlenheim Pharmacal, Inc.2010-09-24Not applicableUs
NaproxenTablet375 mg/1OralSTAT Rx USA LLC2010-02-18Not applicableUs
NaproxenTablet250 mg/1OralCamber Pharmaceuticals2012-01-23Not applicableUs
NaproxenTablet500 mg/1OralClinical Solutions Wholesale2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralRebel Distributors Corp2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralAphena Pharma Solutions Tennessee, Llc2004-04-01Not applicableUs
NaproxenTablet500 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
NaproxenTablet250 mg/1OralKeltman Pharmaceuticals Inc.2009-04-27Not applicableUs
NaproxenTablet250 mg/1OralTeva Pharmaceuticals Usa, Inc.1993-12-222017-06-30Us
NaproxenTablet375 mg/1OralUnit Dose Services2007-07-01Not applicableUs
NaproxenTablet250 mg/1OralTime Cap Laboratories2016-07-06Not applicableUs
NaproxenTablet250 mg/1OralCitron Pharma LLC2011-11-08Not applicableUs
NaproxenTablet, delayed release500 mg/1OralCipla USA Inc.2016-07-05Not applicableUs
NaproxenTablet, delayed release500 mg/1OralREMEDYREPACK INC.2016-10-31Not applicableUs
NaproxenTablet375 mg/1OralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
NaproxenTablet, film coated275 mg/1OralWest ward Pharmaceutical Corp1998-02-18Not applicableUs
NaproxenTablet500 mg/1OralNorthwind Pharmaceuticals2014-05-28Not applicableUs
NaproxenTablet250 mg/1OralPolygen Pharmaceuticals LLC2012-02-01Not applicableUs
NaproxenTablet375 mg/1OralBlenheim Pharmacal, Inc.2009-12-14Not applicableUs
NaproxenTablet500 mg/1OralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralDIRECT RX2014-01-01Not applicableUs
NaproxenTablet250 mg/1OralPd Rx Pharmaceuticals, Inc.2004-01-14Not applicableUs
NaproxenTablet250 mg/1OralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
NaproxenTablet375 mg/1OralAphena Pharma Solutions Tennessee, Llc2010-02-18Not applicableUs
NaproxenSuspension125 mg/5mLOralPalmetto Pharmaceuticals2013-06-25Not applicableUs
NaproxenTablet375 mg/1OralWest Ward Pharmaceuticals Corp2004-01-14Not applicableUs
NaproxenTablet250 mg/1OralAurobindo Pharma Limited2011-11-08Not applicableUs
NaproxenTablet250 mg/1OralApotheca Inc.2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralA S Medication Solutions1993-12-222017-08-31Us
NaproxenTablet250 mg/1OralNu Care Pharmaceuticals, Inc.2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralA S Medication Solutions2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2016-08-30Not applicableUs
NaproxenTablet500 mg/1OralUnit Dose Services2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralRed Pharm Drug, Inc.1993-12-22Not applicableUs
NaproxenTablet250 mg/1OralUnit Dose Services2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralMajor Pharmaceuticals2009-11-20Not applicableUs
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2013-07-09Not applicableUs
NaproxenTablet375 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
NaproxenTablet500 mg/1OralBlenheim Pharmacal, Inc.2013-03-28Not applicableUs
NaproxenTablet250 mg/1OralCardinal Health2009-08-10Not applicableUs
NaproxenTablet500 mg/1OralAidarex Pharmaceuticals LLC2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralGolden State Medical Supply, Inc.2010-02-18Not applicableUs
NaproxenTablet250 mg/1OralMedsource Pharmaceuticals2007-07-01Not applicableUs
NaproxenTablet375 mg/1OralDispensing Solutions, Inc.2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralLife Line Home Care Services, Inc.2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralClinical Solutions Wholesale, Llc1993-12-22Not applicableUs
NaproxenTablet250 mg/1OralA S Medication Solutions2012-01-23Not applicableUs
NaproxenTablet375 mg/1OralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
NaproxenTablet250 mg/1OralCarilion Materials Management2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralA S Medication Solutions2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2015-03-07Not applicableUs
NaproxenTablet375 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-04Not applicableUs
NaproxenTablet375 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-07-18Not applicableUs
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2013-07-25Not applicableUs
NaproxenTablet500 mg/1OralMajor Pharmaceuticals2011-02-28Not applicableUs
NaproxenTablet500 mg/1OralBlenheim Pharmacal,Inc.2015-05-27Not applicableUs
NaproxenTablet, delayed release500 mg/1OralPhysicians Total Care, Inc.2002-01-11Not applicableUs
NaproxenTablet500 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralProficient Rx LP2010-02-18Not applicableUs
NaproxenSuspension125 mg/5mLOralPalmetto Pharmaceuticals2013-06-25Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2016-11-07Not applicableUs
NaproxenTablet250 mg/1OralAv Pak2015-02-05Not applicableUs
NaproxenTablet500 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2013-07-01Not applicableUs
NaproxenTablet500 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralBlenheim Pharmacal, Inc.2011-05-04Not applicableUs
NaproxenTablet500 mg/1OralSTAT Rx USA LLC2011-07-18Not applicableUs
NaproxenTablet500 mg/1OralCardinal Health2009-11-20Not applicableUs
NaproxenTablet375 mg/1OralCamber Pharmaceuticals2012-01-23Not applicableUs
NaproxenTablet550 mg/1OralClinical Solutions Wholesale2010-02-18Not applicableUs
NaproxenTablet375 mg/1Oralbryant ranch prepack2004-01-14Not applicableUs
NaproxenTablet500 mg/1OralPharmaceutica North America, Inc.2013-08-072016-10-13Us
NaproxenTablet375 mg/1OralKeltman Pharmaceuticals Inc.2010-10-04Not applicableUs
NaproxenTablet375 mg/1OralTeva Pharmaceuticals Usa, Inc.1993-12-222017-08-31Us
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2012-08-21Not applicableUs
NaproxenTablet250 mg/1OralGlenmark Pharmaceuticals Inc., Usa2007-07-01Not applicableUs
NaproxenTablet375 mg/1OralA S Medication Solutions2012-01-23Not applicableUs
NaproxenTablet375 mg/1OralCitron Pharma LLC2011-11-08Not applicableUs
NaproxenTablet250 mg/1OralCipla USA Inc.2016-07-05Not applicableUs
NaproxenTablet375 mg/1OralNu Care Pharmaceuticals, Inc.2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
NaproxenTablet250 mg/1OralREMEDYREPACK INC.2011-05-132016-11-29Us
NaproxenTablet500 mg/1OralKAISER FOUNDATION HOSPITALS2008-10-20Not applicableUs
NaproxenTablet375 mg/1OralPolygen Pharmaceuticals LLC2012-02-01Not applicableUs
NaproxenTablet500 mg/1OralBlenheim Pharmacal, Inc.2010-03-17Not applicableUs
NaproxenTablet, delayed release500 mg/1OralRebel Distributors Corp2010-06-02Not applicableUs
NaproxenTablet, delayed release500 mg/1OralPd Rx Pharmaceuticals, Inc.2010-09-23Not applicableUs
NaproxenTablet250 mg/1OralAidarex Pharmaceuticals LLC2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralDIRECT RX2015-01-01Not applicableUs
NaproxenTablet375 mg/1OralPd Rx Pharmaceuticals, Inc.2010-04-22Not applicableUs
NaproxenTablet375 mg/1OralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
NaproxenTablet500 mg/1OralAphena Pharma Solutions Tennessee, Llc2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralWest Ward Pharmaceuticals Corp2004-01-14Not applicableUs
NaproxenTablet375 mg/1OralAurobindo Pharma Limited2011-11-08Not applicableUs
NaproxenTablet500 mg/1OralLake Erie Medical DBA Quality Care Products LLC1993-12-222018-01-31Us
NaproxenTablet500 mg/1OralMc Kesson Contract Packaging2012-01-25Not applicableUs
NaproxenTablet500 mg/1OralClinical Solutions Wholesale, Llc1993-12-22Not applicableUs
NaproxenTablet, delayed release375 mg/1OralTeva Pharmaceuticals Usa, Inc.1998-07-31Not applicableUs
NaproxenTablet250 mg/1OralBiomes Pharmaceuticals2015-03-23Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2016-09-27Not applicableUs
NaproxenTablet250 mg/1OralExelan Pharmaceuticals, Inc.2016-06-10Not applicableUs
NaproxenTablet, delayed release500 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-02-03Not applicableUs
NaproxenTablet500 mg/1OralUnit Dose Services2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralMajor Pharmaceuticals2004-04-01Not applicableUs
NaproxenTablet250 mg/1OralREMEDYREPACK INC.2013-08-27Not applicableUs
NaproxenTablet250 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
NaproxenTablet250 mg/1OralRebel Distributors Corp.2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralCardinal Health2013-09-30Not applicableUs
NaproxenTablet, delayed release375 mg/1OralAidarex Pharmaceuticals LLC1998-07-31Not applicableUs
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2014-11-26Not applicableUs
NaproxenTablet375 mg/1OralSTAT Rx USA LLC2004-01-14Not applicableUs
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2011-03-082016-10-15Us
NaproxenTablet250 mg/1OralContract Pharmacy Services Pa2010-03-19Not applicableUs
NaproxenTablet250 mg/1OralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
NaproxenTablet250 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
NaproxenTablet375 mg/1OralCarilion Materials Management2007-07-01Not applicableUs
NaproxenTablet375 mg/1OralTime Cap Laboratories2016-07-06Not applicableUs
NaproxenTablet, delayed release375 mg/1OralLake Erie Medical DBA Quality Care Products LLC1998-07-31Not applicableUs
NaproxenTablet375 mg/1OralPreferred Pharmaceuticals Inc.2016-06-14Not applicableUs
NaproxenTablet375 mg/1OralREMEDYREPACK INC.Not applicableNot applicableUs
NaproxenTablet, film coated550 mg/1OralLake Erie Medical DBA Quality Care Products LLC1996-05-14Not applicableUs
NaproxenTablet250 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-07-18Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2013-06-042016-04-05Us
NaproxenTablet, delayed release500 mg/1OralH.J. Harkins Company, Inc.2010-09-23Not applicableUs
NaproxenTablet500 mg/1OralBlenheim Pharmacal, Inc.2010-08-19Not applicableUs
NaproxenTablet500 mg/1OralBlenheim Pharmacal, Inc.2015-07-06Not applicableUs
NaproxenTablet250 mg/1OralProficient Rx LP2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralCitron Pharma LLC2011-11-08Not applicableUs
NaproxenTablet375 mg/1OralCipla USA Inc.2016-07-05Not applicableUs
NaproxenTablet500 mg/1OralRed Pharm Drug, Inc.2010-02-18Not applicableUs
NaproxenTablet375 mg/1OralAv Pak2015-02-05Not applicableUs
NaproxenTablet250 mg/1OralMajor Pharmaceuticals2008-11-08Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2013-06-24Not applicableUs
NaproxenTablet500 mg/1OralBlenheim Pharmacal, Inc.2012-02-15Not applicableUs
NaproxenTablet, delayed release500 mg/1OralSTAT Rx USA LLC2010-09-23Not applicableUs
NaproxenTablet250 mg/1OralCardinal Health2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralCamber Pharmaceuticals2012-01-23Not applicableUs
NaproxenTablet500 mg/1Oralbryant ranch prepack2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralSolubiomix2015-08-262016-04-05Us
NaproxenTablet375 mg/1OralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralTeva Pharmaceuticals Usa, Inc.1993-12-222018-01-31Us
NaproxenTablet375 mg/1OralREMEDYREPACK INC.2014-05-01Not applicableUs
NaproxenTablet375 mg/1OralGlenmark Pharmaceuticals Inc., Usa2007-07-01Not applicableUs
NaproxenTablet375 mg/1OralA S Medication Solutions2012-01-23Not applicableUs
NaproxenTablet250 mg/1OralAphena Pharma Solutions Tennessee, Llc2012-01-23Not applicableUs
NaproxenTablet500 mg/1OralUnit Dose Services2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralNu Care Pharmaceuticals, Inc.2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2016-10-27Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2011-08-302016-10-28Us
NaproxenTablet500 mg/1OralLiberty Pharmaceuticals, Inc.2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralPolygen Pharmaceuticals LLC2012-02-01Not applicableUs
NaproxenTablet250 mg/1OralMajor Pharmaceuticals2011-02-28Not applicableUs
NaproxenTablet, film coated550 mg/1OralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
NaproxenTablet500 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2013-03-012016-10-22Us
NaproxenTablet500 mg/1OralProficient Rx LP2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
NaproxenTablet250 mg/1OralAphena Pharma Solutions Tennessee, Llc2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralSt. Mary's Medical Park Pharmacy1999-01-01Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2010-08-182016-11-03Us
NaproxenTablet500 mg/1OralAurobindo Pharma Limited2011-11-08Not applicableUs
NaproxenTablet, delayed release500 mg/1Oralbryant ranch prepack2010-06-02Not applicableUs
NaproxenTablet375 mg/1OralContract Pharmacy Services Pa2010-03-19Not applicableUs
NaproxenTablet, delayed release500 mg/1OralTeva Pharmaceuticals Usa, Inc.1998-07-29Not applicableUs
NaproxenTablet375 mg/1OralBiomes Pharmaceuticals2015-03-23Not applicableUs
NaproxenTablet375 mg/1OralA S Medication Solutions2007-07-01Not applicableUs
NaproxenTablet375 mg/1OralDIRECT RX2016-08-29Not applicableUs
NaproxenTablet375 mg/1OralExelan Pharmaceuticals, Inc.2016-06-10Not applicableUs
NaproxenTablet500 mg/1OralPreferred Pharmaceuticals, Inc.2007-07-01Not applicableUs
NaproxenTablet500 mg/1OralMajor Pharmaceuticals2004-04-01Not applicableUs
NaproxenTablet500 mg/1OralREMEDYREPACK INC.2013-12-05Not applicableUs
NaproxenTablet375 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
NaproxenTablet375 mg/1OralRebel Distributors Corp.2010-02-18Not applicableUs
NaproxenTablet500 mg/1OralCardinal Health2010-12-132016-01-09Us
NaproxenTablet, delayed release500 mg/1OralAidarex Pharmaceuticals LLC1998-07-29Not applicableUs
Naproxen Delayed ReleaseTablet500 mg/1OralCamber Pharmaceuticals2012-01-23Not applicableUs
Naproxen Delayed ReleaseTablet500 mg/1OralA S Medication Solutions2012-01-23Not applicableUs
Naproxen Delayed ReleaseTablet375 mg/1OralAv Kare, Inc.2013-10-24Not applicableUs
Naproxen Delayed ReleaseTablet500 mg/1OralBlenheim Pharmacal, Inc.2015-06-04Not applicableUs
Naproxen Delayed ReleaseTablet500 mg/1OralAv Kare, Inc.2013-10-24Not applicableUs
Naproxen Delayed ReleaseTablet500 mg/1OralPreferred Pharmaceuticals Inc.2016-10-10Not applicableUs
Naproxen Delayed ReleaseTablet375 mg/1OralCamber Pharmaceuticals2012-01-23Not applicableUs
Naproxen Delayed ReleaseTablet, delayed release500 mg/1OralNorthwind Pharmaceuticals2014-05-16Not applicableUs
Naproxen KitKitPharmaceutica North America, Inc2013-08-282016-10-13Us
Naproxen SodiumTablet275 mg/1OralGlenmark Pharmaceuticals Inc., Usa2007-08-01Not applicableUs
Naproxen SodiumTablet275 mg/1OralAv Pak2012-10-11Not applicableUs
Naproxen SodiumTablet550 mg/1OralBlenheim Pharmacal, Inc.2010-03-17Not applicableUs
Naproxen SodiumTablet275 mg/1OralAidarex Pharmaceuticals LLC2007-04-26Not applicableUs
Naproxen SodiumTablet, film coated550 mg/1OralAurobindo Pharma Limited2011-10-31Not applicableUs
Naproxen SodiumTablet220 mg/1OralNorthwind Pharmaceuticals, LLC2014-07-14Not applicableUs
Naproxen SodiumTablet550 mg/1OralDIRECT RX2014-01-01Not applicableUs
Naproxen SodiumTablet550 mg/1OralREMEDYREPACK INC.2013-08-23Not applicableUs
Naproxen SodiumTablet550 mg/1OralAmneal Pharmaceuticals of New York, LLC2007-04-26Not applicableUs
Naproxen SodiumTablet275 mg/1OralBlenheim Pharmacal, Inc.2012-01-12Not applicableUs
Naproxen SodiumTablet550 mg/1OralSTAT Rx USA LLC1998-02-18Not applicableUs
Naproxen SodiumTablet275 mg/1OralHikma Pharmaceutical1998-02-18Not applicableUs
Naproxen SodiumTablet275 mg/1OralMedsource Pharmaceuticals2007-08-01Not applicableUs
Naproxen SodiumTablet, film coated275 mg/1OralTeva Pharmaceuticals USA Inc1993-12-222016-10-31Us
Naproxen SodiumTablet, film coated275 mg/1OralDr. Reddy's Laboratories Inc2016-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralNu Care Pharmaceuticals, Inc.2007-04-26Not applicableUs
Naproxen SodiumTablet250 mg/1OralNorthwind Pharmaceuticals, LLC2014-08-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralPhysicians Total Care, Inc.1994-01-14Not applicableUs
Naproxen SodiumTablet550 mg/1OralProficient Rx LP2007-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Naproxen SodiumTablet550 mg/1Oralbryant ranch prepack2007-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralGlenmark Pharmaceuticals Inc., Usa2007-08-01Not applicableUs
Naproxen SodiumTablet550 mg/1OralAv Pak2012-10-11Not applicableUs
Naproxen SodiumTablet550 mg/1OralREMEDYREPACK INC.2011-11-032016-12-02Us
Naproxen SodiumTablet275 mg/1OralMajor Pharmaceuticals2007-04-26Not applicableUs
Naproxen SodiumTablet, film coated550 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Naproxen SodiumTablet550 mg/1OralRebel Distributors Corp2007-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralAidarex Pharmaceuticals LLC2007-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralA S Medication Solutions2007-08-01Not applicableUs
Naproxen SodiumTablet, film coated550 mg/1OralTeva Pharmaceuticals USA Inc1993-12-222017-01-31Us
Naproxen SodiumTablet, film coated, extended release375 mg/1OralActavis Pharma, Inc.2014-09-30Not applicableUs
Naproxen SodiumTablet550 mg/1OralPreferred Pharmaceuticals, Inc.2007-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralAtlantic Biologicals Corps2007-04-26Not applicableUs
Naproxen SodiumTablet, film coated550 mg/1OralDr. Reddy's Laboratories Inc2016-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralH.J. Harkins Company, Inc.2007-07-01Not applicableUs
Naproxen SodiumTablet, film coated275 mg/1OralPd Rx Pharmaceuticals, Inc.1993-12-22Not applicableUs
Naproxen SodiumTablet275 mg/1OralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Naproxen SodiumTablet275 mg/1OralAv Kare, Inc.2007-04-26Not applicableUs
Naproxen SodiumTablet275 mg/1OralAmneal Pharmaceuticals of New York, LLC2007-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralA S Medication Solutions2007-08-01Not applicableUs
Naproxen SodiumTablet550 mg/1OralNorthwind Pharmaceuticals, LLC2014-08-07Not applicableUs
Naproxen SodiumTablet550 mg/1OralMajor Pharmaceuticals2007-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Naproxen SodiumTablet220 mg/1OralDIRECT RX2016-03-07Not applicableUs
Naproxen SodiumTablet550 mg/1OralA S Medication Solutions2007-04-26Not applicableUs
Naproxen SodiumTablet, film coated, extended release500 mg/1OralActavis Pharma, Inc.2014-09-30Not applicableUs
Naproxen SodiumTablet550 mg/1OralA S Medication Solutions2007-04-26Not applicableUs
Naproxen SodiumTablet275 mg/1OralBlenheim Pharmacal, Inc.2013-08-26Not applicableUs
Naproxen SodiumTablet275 mg/1Oralbryant ranch prepack2007-08-01Not applicableUs
Naproxen SodiumTablet550 mg/1OralKeltman Pharmaceuticals Inc.2010-12-10Not applicableUs
Naproxen SodiumTablet550 mg/1OralA S Medication Solutions2007-04-26Not applicableUs
Naproxen SodiumTablet275 mg/1OralPd Rx Pharmaceuticals, Inc.2007-08-01Not applicableUs
Naproxen SodiumTablet, film coated550 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2010-11-01Not applicableUs
Naproxen SodiumTablet275 mg/1OralAmneal Pharmaceuticals of New York, LLC2007-04-26Not applicableUs
Naproxen SodiumTablet, film coated550 mg/1OralNew Horizon Rx Group, LLC2013-08-25Not applicableUs
Naproxen SodiumTablet550 mg/1OralAv Kare, Inc.2007-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralAmneal Pharmaceuticals of New York, LLC2007-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralPd Rx Pharmaceuticals, Inc.2007-04-26Not applicableUs
Naproxen SodiumTablet550 mg/1OralRx Change Co.2014-11-11Not applicableUs
Naproxen SodiumTablet550 mg/1OralSTAT Rx USA LLC2007-08-01Not applicableUs
Naproxen SodiumTablet550 mg/1OralREMEDYREPACK INC.2011-06-092016-10-13Us
Naproxen SodiumTablet550 mg/1OralLake Erie Medical DBA Quality Care Products LLC2007-04-26Not applicableUs
Naproxen SodiumTablet, film coated275 mg/1OralAurobindo Pharma Limited2011-10-31Not applicableUs
Naproxen SodiumTablet550 mg/1OralUnit Dose Services2007-04-26Not applicableUs
Naproxen SodiumTablet275 mg/1OralBlenheim Pharmacal, Inc.2010-03-22Not applicableUs
Naproxen TabletsTablet375 mg/1OralDr. Reddy's Laboratories Limited2004-06-052016-10-13Us
Naproxen TabletsTablet500 mg/1OralDr. Reddy's Laboratories Limited2004-06-052016-10-13Us
Naproxen TabletsTablet250 mg/1OralDr. Reddy's Laboratories Limited2004-06-052016-10-13Us
Sallus Pain Relief Collection With NaproxenKitSallus Laboratories, Llc2007-07-01Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select Naproxen SodiumTablet, film coated220 mg/1Oral7 Eleven2014-08-05Not applicableUs
7 Select Naproxen SodiumTablet220 mg/1Oral7 Eleven2014-08-11Not applicableUs
AleveTablet220 mg/1OralBayer Health Care Consumer Care2002-07-26Not applicableUs
AleveTablet220 mg/1OralR J General Corporation2014-02-26Not applicableUs
AleveTablet220 mg/1OralLil' Drug Store Products, Inc2000-01-01Not applicableUs
AleveCapsule, liquid filled220 mg/1OralBayer Health Care Llc, Consumer Care2007-02-20Not applicableUs
AleveTablet220 mgOralBayer Inc Consumer Care2009-06-15Not applicableCanada
AleveTablet220 mg/1OralNavajo Manufacturing Company Inc.2016-09-17Not applicableUs
AleveTablet220 mg/1OralCardinal Health1994-01-11Not applicableUs
Aleve Back and Body PainCapsule220 mgOralBayer Inc Consumer Care2015-06-30Not applicableCanada
Aleve CapletsTablet220 mg/1OralJc World Bell Wholesale Co., Inc.2014-07-142016-10-19Us
Aleve CapletsTablet220 mg/1OralYour Safety Company2016-03-15Not applicableUs
Aleve CapletsTablet220 mg/1OralBayer Health Care Llc, Consumer Care2014-02-26Not applicableUs
Aleve Caplets - Easy Open Arthritis CapTablet220 mg/1OralBayer Health Care Consumer Care2013-11-11Not applicableUs
Aleve Easy Open Arthritis CapCapsule, liquid filled220 mg/1OralBayer Health Care Llc, Consumer Care2007-02-28Not applicableUs
Aleve Easy Open Arthritis CapTablet220 mg/1OralBayer Health Care Consumer Care2002-07-26Not applicableUs
Aleve GelcapsTablet, coated220 mg/1OralBayer Health Care Consumer Care2002-08-01Not applicableUs
Aleve GelcapsTablet, coated220 mg/1OralBayer Health Care Consumer Care2002-08-01Not applicableUs
Aleve Liquid GelsCapsule220 mgOralBayer Inc Consumer Care2011-09-12Not applicableCanada
All Day Pain ReliefTablet220 mg/1OralH E B1997-02-24Not applicableUs
All Day Pain ReliefTablet220 mg/1OralCVS Pharmacy1997-01-23Not applicableUs
All Day Pain ReliefCapsule, liquid filled220 mg/1OralHarmon Stores2015-07-31Not applicableUs
All Day Pain ReliefTablet220 mg/1OralCardinal Health (Leader) 497812012-06-25Not applicableUs
All Day Pain ReliefTablet220 mg/1OralFreds Inc2015-09-30Not applicableUs
All Day Pain ReliefTablet220 mg/1OralEqualine (Super Valu)2013-05-09Not applicableUs
All Day Pain ReliefTablet220 mg/1OralP And L Development Of New York Corporation (Ready In Case)2014-06-30Not applicableUs
All Day Pain ReliefTablet220 mg/1OralHealth Life of Usa Llc2011-09-30Not applicableUs
All Day Pain ReliefTablet220 mg/1OralRebel Distributors Corp1997-01-14Not applicableUs
All Day Pain ReliefTablet, film coated220 mg/1OralH E B1997-02-24Not applicableUs
All Day Pain ReliefTablet, film coated220 mg/1OralHannaford Brothers Company1997-04-09Not applicableUs
All Day Pain ReliefTablet220 mg/1OralH E B2015-09-30Not applicableUs
All Day Pain ReliefTablet220 mg/1OralCVS Pharmacy2014-04-30Not applicableUs
All Day Pain ReliefTablet, film coated200 mg/1OralH E B2008-02-12Not applicableUs
All Day Pain ReliefTablet220 mg/1OralWalgreens2014-03-31Not applicableUs
All Day Pain ReliefTablet220 mg/1OralFreds Inc2014-03-28Not applicableUs
All Day Pain ReliefTablet220 mg/1OralSuper Valu (Equaline)2010-11-15Not applicableUs
All Day Pain ReliefTablet220 mg/1OralP And L Development Of New York Corporation (Ready In Case)2014-02-28Not applicableUs
All Day Pain ReliefTablet220 mg/1OralHannaford Brothers Company1997-04-09Not applicableUs
All Day Pain ReliefTablet200 mg/1OralWalgreen Company2014-07-31Not applicableUs
All Day Pain ReliefTablet220 mg/1OralCardinal Health (Leader) 497812015-11-30Not applicableUs
All Day Pain ReliefTablet220 mg/1OralTOP CARE (Topco Associates LLC)2014-06-30Not applicableUs
All Day Pain ReliefTablet220 mg/1OralWalgreens2014-03-31Not applicableUs
All Day Pain ReliefTablet220 mg/1OralCardinal Health (Leader) 497812014-07-31Not applicableUs
All Day Pain ReliefTablet220 mg/1OralCardinal Health (Leader)2012-08-30Not applicableUs
All Day Pain ReliefTablet220 mg/1OralFreds Inc2014-08-31Not applicableUs
All Day Pain ReliefTablet220 mg/1OralP And L Development Of New York Corporation (Ready In Case)2014-03-28Not applicableUs
All Day Pain ReliefTablet, film coated220 mg/1OralCVS Pharmacy1997-01-23Not applicableUs
All Day Pain ReliefTablet220 mg/1OralCardinal Health (Leader) 497812015-11-30Not applicableUs
All Day Pain ReliefTablet220 mg/1OralThe Kroger Co.2011-02-02Not applicableUs
All Day Pain ReliefTablet, film coated220 mg/1OralWalgreen Company1997-01-14Not applicableUs
All Day Pain ReliefTablet, film coated220 mg/1OralCVS Pharmacy2005-09-26Not applicableUs
All Day Pain ReliefTablet220 mg/1OralWe Care Distributor Inc.2011-09-30Not applicableUs
All Day Pain ReliefTablet220 mg/1OralSelect Brand Dist.2016-06-30Not applicableUs
All Day Pain ReliefTablet220 mg/1OralCardinal Health (Leader) 497812012-06-25Not applicableUs
All Day Pain ReliefTablet220 mg/1OralFreds Inc2015-09-30Not applicableUs
All Day Pain Relief Naproxen SodiumTablet220 mg/1OralAmerican Health Packaging2015-06-05Not applicableUs
All Day Pain Relief Naproxen SodiumTablet220 mg/1OralCamber Consumer Care2015-05-26Not applicableUs
All Day ReliefTablet220 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1997-01-09Not applicableUs
All Day ReliefTablet220 mg/1OralRugby Laboratories2014-03-10Not applicableUs
All Day ReliefTablet220 mg/1OralMajor Pharmaceuticals1997-01-09Not applicableUs
All Day ReliefTablet, film coated220 mg/1OralWestern Family Foods Inc1997-01-14Not applicableUs
All Day ReliefTablet, film coated220 mg/1OralHy Vee Inc2008-09-02Not applicableUs
All Day ReliefTablet220 mg/1OralMeijer Distribution Inc1997-05-29Not applicableUs
All Day ReliefTablet220 mg/1OralLake Erie Medical DBA Quality Care Products LLC2014-03-102016-01-21Us
All Day ReliefTablet, film coated220 mg/1OralMajor Pharmaceuticals1997-01-09Not applicableUs
All Day ReliefTablet220 mg/1OralWestern Family Foods Inc1997-01-15Not applicableUs
All Day ReliefTablet, film coated220 mg/1OralMeijer Distribution Inc2004-05-28Not applicableUs
All Day ReliefTablet, film coated220 mg/1OralWestern Family Foods Inc2007-12-19Not applicableUs
All Day ReliefTablet, film coated220 mg/1OralPublix Super Markets Inc1997-12-29Not applicableUs
All Day ReliefTablet, film coated220 mg/1OralHy Vee Inc1997-04-01Not applicableUs
All Day ReliefTablet, film coated220 mg/1OralKroger Company1997-01-16Not applicableUs
All Day ReliefTablet220 mg/1OralH.J. Harkins Company, Inc.1997-01-09Not applicableUs
All Day ReliefTablet220 mg/1OralClinical Solutions Wholesale1997-01-09Not applicableUs
All Day ReliefTablet220 mg/1OralRugby Laboratories2014-03-10Not applicableUs
All Day ReliefTablet, film coated220 mg/1OralMedicine Shoppe International Inc2001-09-03Not applicableUs
All Day ReliefTablet220 mg/1OralPublix Super Markets Inc1997-12-29Not applicableUs
All Day ReliefTablet220 mg/1OralPreferred Pharmaceuticals Inc.2015-05-06Not applicableUs
All Day ReliefTablet, film coated220 mg/1OralKroger Company2005-02-08Not applicableUs
All Day ReliefTablet, film coated220 mg/1OralMeijer Distribution Inc1997-01-23Not applicableUs
All Day ReliefTablet220 mg/1OralHy Vee Inc1997-04-01Not applicableUs
All Day ReliefTablet220 mg/1OralKroger Company2004-05-10Not applicableUs
Bayer AleveTablet220 mg/1OralUnifirst First Aid Corporation2014-01-24Not applicableUs
Being Well All Day Pain ReliefTablet, film coated220 mg/1OralSave A Lot Food Stores Ltd2006-02-25Not applicableUs
Berkley and Jensen Naproxen SodiumTablet, film coated220 mg/1OralBJWC2007-09-17Not applicableUs
Calmadol Pain RelieverTablet220 mg/1OralGrandall Distributing Co., Inc.2015-03-31Not applicableUs
Care One All Day Pain ReliefTablet, film coated220 mg/1OralAmerican Sales Company2008-09-26Not applicableUs
Care One All Day Pain ReliefTablet, film coated220 mg/1OralAmerican Sales Company2004-04-05Not applicableUs
Care One All Day Pain ReliefTablet220 mg/1OralAmerican Sales Company2004-05-04Not applicableUs
Care One Naproxen SodiumTablet, film coated220 mg/1OralAmerican Sales Company2016-06-13Not applicableUs
Care One Naproxen SodiumTablet220 mg/1OralAmerican Sales Company2016-07-08Not applicableUs
Careall NaproxenCapsule220 mg/1OralNew World Imports, Inc.2013-05-01Not applicableUs
Careone Naproxen SodiumTablet, film coated220 mg/1OralAmerican Sales Company2016-08-05Not applicableUs
Careone Naproxen SodiumCapsule, liquid filled220 mg/1OralAmerican Sales Company2011-12-08Not applicableUs
Dg Health All Day Pain ReliefTablet, film coated220 mg/1OralDolgencorp Inc2010-01-17Not applicableUs
Dg Health Naproxen SodiumCapsule, liquid filled220 mg/1OralDolgencorp, LLC2011-06-01Not applicableUs
Dg Health Naproxen SodiumTablet220 mg/1OralDolgencorp, LLC2016-04-25Not applicableUs
Dg Health Naproxen SodiumTablet, film coated220 mg/1OralDolgencorp, LLC2013-11-21Not applicableUs
Equaline All Day Pain ReliefTablet, film coated220 mg/1OralSupervalu Inc2004-08-10Not applicableUs
Equaline All Day Pain ReliefTablet220 mg/1OralSupervalu Inc2004-08-10Not applicableUs
Equaline All Day Pain ReliefTablet, film coated220 mg/1OralSupervalu Inc2005-02-08Not applicableUs
Equaline Naproxen SodiumTablet220 mg/1OralSupervalu Inc2014-09-24Not applicableUs
Equaline Naproxen SodiumCapsule, liquid filled220 mg/1OralSupervalu Inc2010-11-23Not applicableUs
Equaline Naproxen SodiumTablet, film coated220 mg/1OralSupervalu Inc2014-09-24Not applicableUs
Equaline Naproxen SodiumTablet, film coated220 mg/1OralSupervalu Inc2014-07-14Not applicableUs
Equate Naproxen SodiumTablet220 mg/1OralWal Mart Stores Inc2007-05-02Not applicableUs
Equate Naproxen SodiumCapsule, liquid filled220 mg/1OralWal Mart Stores Inc2013-08-09Not applicableUs
Equate Naproxen SodiumTablet200 mg/1OralWal Mart Stores Inc2013-09-11Not applicableUs
Equate Naproxen SodiumTablet, film coated200 mg/1OralWal Mart Stores Inc2013-08-09Not applicableUs
Equate Naproxen SodiumCapsule, liquid filled220 mg/1OralWal Mart Stores Inc2011-07-26Not applicableUs
Equate Naproxen SodiumTablet, film coated220 mg/1OralWal Mart Stores Inc2007-04-27Not applicableUs
Exchange Select Naproxen SodiumTablet, film coated220 mg/1OralArmy & Air Force Exchange Service2008-08-26Not applicableUs
Family Wellness Naproxen SodiumTablet, film coated220 mg/1OralFamily Dollar Services Inc1997-01-14Not applicableUs
Flanax Pain and Fever RelieverTablet220 mg/1OralNavajo Manufacturing Company Inc.2016-09-20Not applicableUs
Flanax Pain RelieverTablet220 mg/1OralBelmora LLC2008-12-16Not applicableUs
Formucare Naproxen Sodium Pain Reliever Fever ReducerTablet, film coated220 mg/1OralAccess Business Group International LLC2009-09-29Not applicableUs
Fulton Street Market Naproxen SodiumTablet, film coated220 mg/1OralAccess Business Group LLC2000-07-06Not applicableUs
Good Neighbor Pharmacy Naproxen SodiumTablet, film coated220 mg/1OralAmerisource Bergen2015-08-03Not applicableUs
Good Neighbor Pharmacy Naproxen SodiumTablet220 mg/1OralAmerisource Bergen1998-03-12Not applicableUs
Good Neighbor Pharmacy Naproxen SodiumCapsule, liquid filled220 mg/1OralAmerisource Bergen2011-01-06Not applicableUs
Good Neighbor Pharmacy Pain Relief All DayTablet, film coated220 mg/1OralAmerisource Bergen1997-01-15Not applicableUs
Good Sense All Day Pain ReliefTablet, film coated200 mg/1OralL. Perrigo Company1997-01-14Not applicableUs
Good Sense All Day Pain ReliefTablet220 mg/1OralAidarex Pharmaceuticals LLC1997-01-14Not applicableUs
Good Sense All Day Pain ReliefTablet220 mg/1OralL Perrigo Company1997-01-14Not applicableUs
Good Sense All Day Pain ReliefTablet220 mg/1OralUnit Dose Services1997-01-14Not applicableUs
Good Sense All Day Pain ReliefTablet220 mg/1OralProficient Rx LP1997-01-14Not applicableUs
Good Sense All Day Pain ReliefTablet220 mg/1OralDispensing Solutions, Inc.1997-01-14Not applicableUs
Good Sense Naproxen SodiumCapsule, liquid filled220 mg/1OralL. Perrigo Company2010-12-02Not applicableUs
Good Sense Naproxen SodiumTablet220 mg/1OralL. Perrigo Company2014-04-23Not applicableUs
Good Sense Naproxen SodiumTablet, film coated220 mg/1OralL. Perrigo Company2014-03-31Not applicableUs
Health Mart Naproxen SodiumCapsule, liquid filled220 mg/1OralMc Kesson2011-11-21Not applicableUs
Health Mart Naproxen SodiumTablet, film coated220 mg/1OralMc Kesson2011-11-21Not applicableUs
Healthy Accents All Day Pain ReliefTablet220 mg/1OralDZA Brands LLC2011-07-19Not applicableUs
Healthy Accents All Day Pain ReliefTablet, film coated220 mg/1OralDZA Brands LLC2008-01-22Not applicableUs
Healthy Accents Naproxen SodiumTablet, film coated220 mg/1OralDZA Brands LLC2008-01-22Not applicableUs
Healthy Accents Naproxen SodiumTablet220 mg/1OralDZA Brands LLC2011-07-19Not applicableUs
Healthy Accents Naproxen SodiumCapsule, liquid filled220 mg/1OralDZA Brands LLC2012-04-05Not applicableUs
Healthy Accents Naproxen SodiumTablet, film coated220 mg/1OralDZA Brands LLC2013-05-22Not applicableUs
Kirkland Signature Naproxen SodiumTablet, film coated220 mg/1OralCostco Wholesale Company2007-06-04Not applicableUs
Leader All DayTablet220 mg/1OralCardinal Health2015-04-29Not applicableUs
Leader All Day Pain ReliefTablet, film coated220 mg/1OralCardinal Health (Leader) 372052001-09-26Not applicableUs
Leader All Day Pain ReliefTablet, film coated220 mg/1OralCardinal Health (Leader) 372052012-06-25Not applicableUs
Leader All Day Pain ReliefTablet220 mg/1OralCardinal Health2016-11-29Not applicableUs
Leader All Day Pain ReliefTablet, film coated220 mg/1OralCardinal Health2015-03-12Not applicableUs
Leader Naproxen SodiumCapsule, liquid filled220 mg/1OralCardinal Health2010-12-01Not applicableUs
Lil Drug Store Pain Relief All DayTablet220 mg/1OralLil' Drug Store Products, Inc.2011-01-27Not applicableUs
Maxidol Liquid GelsCapsule220 mgOralBayer Inc Consumer Care2012-05-17Not applicableCanada
Medique MediproxenTablet, film coated220 mg/1OralUnifirst First Aid Corporation2008-12-30Not applicableUs
Members Mark Naproxen SodiumTablet, film coated220 mg/1OralSam's West Inc2007-05-29Not applicableUs
MenstridolTablet220 mg/1OralBayer Health Care Llc, Consumer Care2014-07-01Not applicableUs
Midol Extended ReliefTablet220 mg/1OralBayer Health Care Llc, Consumer Care2009-10-20Not applicableUs
Modern Pain MedicineTablet220 mg/1OralAthlete's Needs Inc2013-05-06Not applicableUs
Motrimax 12 Hour Back & BodyCapsule200 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Motrimax 12 Hour TabletsTablet220 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
NaproxenTablet220 mg/1OralMedline Industries, Inc.2002-07-26Not applicableUs
NaproxenTablet220 mgOralPharmel IncNot applicableNot applicableCanada
NaproxenCapsule220 mg/1OralChain Drug Consortium2014-10-27Not applicableUs
NaproxenTablet220 mgOralPerrigo International2013-09-16Not applicableCanada
NaproxenTablet220 mg/1OralZee Medical Inc2015-03-31Not applicableUs
NaproxenTablet220 mg/1OralPharmadel LLC2013-03-25Not applicableUs
NaproxenTablet220 mg/1OralChain Drug Consortium2014-10-27Not applicableUs
NaproxenTablet220 mgOralPharmascience Inc2011-03-18Not applicableCanada
Naproxen All Day Relief for PainTablet220 mg/1OralAllegiant Health2014-12-23Not applicableUs
Naproxen Caplets All Day Relief for PainTablet220 mg/1OralAllegiant Health2014-12-23Not applicableUs
Naproxen Liquid GelsCapsule220 mgOralPharmascience IncNot applicableNot applicableCanada
Naproxen Menstrual Pain ReliefTablet220 mgOralPharmascience Inc2014-01-24Not applicableCanada
Naproxen Pain ReliefTablet220 mg/1OralRebel Distributors Corp1998-03-12Not applicableUs
Naproxen SodiumTablet220 mg/1OralMARKSANS PHARMA LIMITED2011-05-04Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralAafes/Your Military Exchanges2015-11-30Not applicableUs
Naproxen SodiumTablet, film coated, extended release220 mg/1OralSPIRIT PHARMACEUTICALS,LLC2011-08-01Not applicableUs
Naproxen SodiumTablet220 mg/1OralRite Aid Corporation2001-05-16Not applicableUs
Naproxen SodiumTablet220 mg/1OralKroger Company2014-03-06Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralShopko Stores Operating Co., LLC2013-07-30Not applicableUs
Naproxen SodiumTablet220 mg/1OralGranules India Limited2011-09-30Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralWin Co Foods, Llc2014-12-15Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralMeijer Distribution Inc2014-03-05Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralHy Vee Inc2010-11-29Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralWalgreen Company2014-08-04Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralThe Kroger Co.2014-10-31Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralPolygen Pharmaceuticals LLC2012-06-11Not applicableUs
Naproxen SodiumTablet220 mg/1OralFamily Dollar (FAMILY WELLNESS)2012-08-15Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralMEIJER, INC.2014-09-30Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralAAA Pharmaceutical, Inc.2012-12-15Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralKinray LLC2014-04-25Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2014-11-30Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralWalgreen Company2010-11-30Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralDr.Reddy's Laboratories Limited1998-07-29Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralHealthy Accents (DZA Brands, LLC)2013-12-30Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralQUALITY CHOICE (Chain Drug Marketing Association)2014-10-31Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralRite Aid Corporation2001-05-16Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralTIME CAP LABORATORIES, INC2015-12-07Not applicableUs
Naproxen SodiumTablet220 mg/1OralThe Kroger Co.2014-11-09Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralTOP CARE (Topco Associates LLC)2014-09-30Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralPublix Supermarkets, Inc.2015-06-30Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralCVS Pharmacy2010-11-23Not applicableUs
Naproxen SodiumTablet220 mg/1OralPreferred Pharmaceuticals Inc.2016-06-09Not applicableUs
Naproxen SodiumTablet220 mg/1OralPerrigo New York Inc2014-04-11Not applicableUs
Naproxen SodiumTablet220 mg/1OralCardinal Health (Leader) 497812014-07-31Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralKroger Company1997-01-16Not applicableUs
Naproxen SodiumTablet220 mg/1OralGranules India Limited2011-09-30Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralMaximino Import2008-08-20Not applicableUs
Naproxen SodiumTablet200 mg/1OralCVS Pharmacy2016-01-05Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralHy Vee2014-09-30Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralSafeway, Inc.2015-02-28Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralSMART SENSE (Kmart)2014-12-31Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralKroger Company2005-02-08Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralPolygen Pharmaceuticals LLC2012-11-13Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralH E B2011-01-04Not applicableUs
Naproxen SodiumTablet220 mg/1OralFamily Dollar (FAMILY WELLNESS)2013-11-01Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralAAA Pharmaceutical, Inc.2012-12-15Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralChain Drug Marketing Association2009-09-03Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralCVS Pharmacy2015-07-22Not applicableUs
Naproxen SodiumTablet220 mg/1OralProductos Zapotol Corp.2016-05-31Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralDr.Reddy's Laboratories Limited1998-07-29Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralHealthy Accents (DZA Brands, LLC)2014-09-30Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralCVS Pharmacy2014-11-30Not applicableUs
Naproxen SodiumTablet220 mg/1OralEQUATE (Walmart Stores, Inc.)2014-02-12Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralRite Aid Corporation2010-12-15Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralTIME CAP LABORATORIES, INC2015-12-16Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralKroger Company2014-03-15Not applicableUs
Naproxen SodiumTablet220 mg/1OralKinray2009-11-25Not applicableUs
Naproxen SodiumTablet220 mg/1OralTYA Pharmaceuticals2014-04-11Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralPreferred Pharmaceuticals, Inc.2012-03-12Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralWalgreens2014-10-31Not applicableUs
Naproxen SodiumTablet220 mg/1OralAllegiant Health2014-12-23Not applicableUs
Naproxen SodiumTablet220 mg/1OralMeijer Distribution Inc2014-03-05Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralTarget Corporation2014-12-30Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralSafeway2010-12-13Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralKroger Company2010-11-23Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralEqualine (Super Valu)2014-09-30Not applicableUs
Naproxen SodiumTablet220 mg/1OralNu Care Pharmaceuticals, Inc.2014-04-11Not applicableUs
Naproxen SodiumTablet200 1/1OralAdvanced First Aid, Inc.2015-04-09Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralRite Aid Corporation2016-07-01Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralCVS Pharmacy2016-03-15Not applicableUs
Naproxen SodiumTablet220 mg/1OralEQUATE (Walmart Stores, Inc.)2014-04-30Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralShopko Stores Operating Co., LLC.2014-12-31Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralWestern Family Foods Inc2011-01-18Not applicableUs
Naproxen SodiumTablet220 mg/1OralFamily Dollar (FAMILY WELLNESS)2014-04-30Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralMeijer Distribution Inc2004-05-28Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralChain Drug Marketing Association2009-06-19Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralCare One (American Sales Company)2014-10-31Not applicableUs
Naproxen SodiumTablet220 mg/1OralMARKSANS PHARMA LIMITED2011-05-28Not applicableUs
Naproxen SodiumTablet220 mg/1OralTOP CARE (Topco Associates LLC)2014-06-30Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralH E B2015-07-31Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralEQUATE (Walmart Stores, Inc.)2014-09-30Not applicableUs
Naproxen SodiumTablet220 mg/1OralRugby Laboratories Inc2009-11-25Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralWestern Family Foods, Inc.2014-12-31Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralKinray LLC2014-04-25Not applicableUs
Naproxen SodiumTablet220 mg/1OralVitamex Usa2016-03-31Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralMeijer Distribution Inc2011-01-14Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralAmerisource Bergen (Good Neighbor Pharmacy) 461222014-11-30Not applicableUs
Naproxen SodiumTablet220 mg/1OralPhysicians Total Care, Inc.2005-05-23Not applicableUs
Naproxen SodiumTablet220 mg/1OralProficient Rx LP2014-04-11Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralAurohealth LLC2016-03-18Not applicableUs
Naproxen SodiumTablet220 mg/1OralFamily Dollar (FAMILY WELLNESS)2014-04-30Not applicableUs
Naproxen SodiumTablet, film coated, extended release220 mg/1OralJ.P. BUSINESS ENTERPRISE2013-08-20Not applicableUs
Naproxen SodiumCapsule, liquid filled220 mg/1OralMc Kesson (Health Mart)2014-10-31Not applicableUs
Naproxen SodiumTablet, coated220 mg/1OralWin Co Foods, Llc2014-12-15Not applicableUs
Naproxen SodiumTablet220 mg/1OralMedline Industries2013-04-30Not applicableUs
Naproxen SodiumTablet, film coated220 mg/1OralShopko Stores Operating Co., LLC2014-05-19Not applicableUs
Naproxen Sodium (nsaid) Fever Reducer/ Pain RelieverTablet220 mg/1OralAmneal Pharmaceuticals2009-11-25Not applicableUs
Naproxen Sodium (nsaid) Fever Reducer/ Pain RelieverTablet220 mg/1OralAmneal Pharmaceuticals2009-11-25Not applicableUs
Naproxen Sodium All Day Pain ReliefTablet, film coated220 mg/1OralRite Aid Corporation2001-05-16Not applicableUs
Naproxen Sodium CapletsTablet220 mgOralVita Health Products IncNot applicableNot applicableCanada
Naproxen Sodium TabletsTablet220 mgOralVita Health Products IncNot applicableNot applicableCanada
Naproxen Sodium TabletsTablet220 mgOralApotex Inc2014-03-06Not applicableCanada
Nx 12 HourTablet220 mgOralPerrigo InternationalNot applicableNot applicableCanada
Pain ReliefTablet, film coated220 mg/1OralWalgreen Company2011-10-22Not applicableUs
Pain ReliefTablet, film coated220 mg/1OralSafeway2015-03-02Not applicableUs
Pain Relief All DayTablet, film coated220 mg/1OralSafeway2008-10-03Not applicableUs
Pain Relief All DayTablet220 mg/1OralWalgreen Company1997-01-14Not applicableUs
Pain Relief All DayTablet, film coated220 mg/1OralSafeway2007-09-12Not applicableUs
Pain ZeroTablet220 mg/1OralProvision Medical Products2015-03-31Not applicableUs
Rexall All Day Pain ReliefTablet, film coated220 mg/1OralDolgencorp Inc2012-09-28Not applicableUs
Rexall All Day Pain ReliefTablet, film coated220 mg/1OralDolgencorp, LLC2013-07-31Not applicableUs
Rugby All Day ReliefTablet, film coated220 mg/1OralRugby Laboratories2015-09-02Not applicableUs
Rugby All Day ReliefTablet220 mg/1OralPreferred Pharmaceuticals Inc.2016-02-01Not applicableUs
Rugby All Day ReliefTablet220 mg/1OralRugby Laboratories2015-09-02Not applicableUs
Rugby All Day ReliefTablet, film coated220 mg/1OralLake Erie Medical DBA Quality Care Products LLC2015-09-02Not applicableUs
Rx Act All Day Pain ReliefTablet, film coated220 mg/1OralH E B2008-02-12Not applicableUs
Rx Act All Day Pain ReliefTablet, film coated220 mg/1OralH E B2009-02-12Not applicableUs
Rx Act All Day Pain ReliefTablet220 mg/1OralH E B1997-02-24Not applicableUs
Rx Act Naproxen SodiumCapsule, liquid filled220 mg/1OralH E B2011-01-04Not applicableUs
Shoprite Naproxen SodiumTablet, film coated220 mg/1OralWakefern Food Corporation2013-08-14Not applicableUs
Shoprite Naproxen SodiumCapsule, liquid filled220 mg/1OralWakefern Food Corporation2013-06-20Not applicableUs
Signature Care Pain ReliefTablet, film coated220 mg/1OralSafeway2015-09-04Not applicableUs
Signature Care Pain ReliefTablet, film coated220 mg/1OralSafeway2015-09-29Not applicableUs
Signature Care Pain ReliefTablet220 mg/1OralSafeway2015-10-24Not applicableUs
Simply Right Naproxen SodiumTablet, film coated220 mg/1OralSam's West Inc2014-02-12Not applicableUs
Simply Right Naproxen SodiumCapsule, liquid filled220 mg/1OralSam's West Inc2011-06-09Not applicableUs
Smart Sense Naproxen SodiumTablet220 mg/1OralKmart Corporation2010-07-15Not applicableUs
Smart Sense Naproxen SodiumTablet, film coated220 mg/1OralKmart Corporation2010-10-08Not applicableUs
Smart Sense Naproxen SodiumTablet, film coated220 mg/1OralKmart Corporation2010-10-01Not applicableUs
Smart Sense Naproxen SodiumCapsule, liquid filled220 mg/1OralKmart Corporation2011-06-22Not applicableUs
Sunmark All Day ReliefTablet, film coated220 mg/1OralMc Kesson2003-08-11Not applicableUs
Sunmark All Day ReliefTablet220 mg/1OralMc Kesson2003-08-21Not applicableUs
Sunmark Naproxen SodiumCapsule, liquid filled220 mg/1OralMc Kesson2010-12-07Not applicableUs
Sunmark Naproxen SodiumTablet, film coated220 mg/1OralMc Kesson2003-08-11Not applicableUs
Sunmark Naproxen SodiumTablet220 mg/1OralMc Kesson2003-08-21Not applicableUs
Topcare All Day Pain ReliefTablet, film coated220 mg/1OralTopco Associates LLC2007-12-03Not applicableUs
Topcare All Day Pain ReliefTablet220 mg/1OralTopco Associates LLC1997-01-14Not applicableUs
Topcare All Day Pain ReliefTablet, film coated220 mg/1OralTopco Associates LLC1997-01-14Not applicableUs
Topcare Naproxen SodiumCapsule, liquid filled220 mg/1OralTopco Associates LLC2010-11-23Not applicableUs
Up and Up Naproxen SodiumTablet220 mg/1OralTarget Corporation2009-07-14Not applicableUs
Up and Up Naproxen SodiumCapsule, liquid filled220 mg/1OralTarget Corporation2011-01-05Not applicableUs
Up and Up Naproxen SodiumTablet, film coated220 mg/1OralTarget Corporation2009-06-24Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Equipto - Naproxen External Cream Compounding KitKitTopicalAlvix Laboratories, LLC2015-01-20Not applicableUs
International Brands
NameCompany
AlidaseLaboratorios
AlpoxenActavis
AlpronAldril
ApainMarvic
ApranaxRoche
ApronaxBayer
BonylOrion
BruproxenBruluart
Bumaflex NNycomed
CongexBuxton
DebrilMonserrat
DeproxenDrug International
DysmenalgitKrewel Meuselbach
EmoxEmo-Farm
EmoxenEMO
EurogesicSaval
FabralginaFabra
Feminax UltraBayer
FlogotoneInterpharma
GerinapGerard
HonlowPanion & BF
ImprostanFarmacoop
InflamaxFarmaceutica
InzaAlphapharm
IraxenQuilab
JinkangpuliConba
LexinaxBrisafarma
MelgarHexa
MesselxenBiomep
MobilatSTADA
NaprometinRoche
Naprosyn CRAbdi Ibrahim
Naprosyn ECRoche
Naprosyn EnteroRoche
Naprosyn SRRoche
NaprosyneRoche
NaprovalLabinco
NapruxAndromaco
NeuralpronaLba
NoflamMylan
NopainMedicef
PrexanNew Research
PriaxenRemedica
PrincepsLaser
PronaxenOrion
ProxenGrünenthal
Proxen SRoche
Proxen SRRoche
ReleveGeneral Pharma
ReproDoctor's Chemical Works
ReuxenHelcor
RiproxenBioGenet
SanaproxPerumed
SeladinYSP
ServinaproxNovartis
TarproxenPolfa Tarchomin
TicoflexIncepta
TundraFrasca
XenarElder
Xenar-CRElder
Brand mixtures
NameLabellerIngredients
Aleve NighttimeBayer Inc Consumer Care
Aleve PMBayer Health Care Consumer Care
All Day Sinus and Cold DHy Vee Inc
Good Neighbor Pharmacy Sinus and Cold DAmerisource Bergen
Health Mart Sinus and Cold DMc Kesson
Leader Sinus and Cold-DCardinal Health
Naproxen Capsules 200 mgAccucaps Industries Limited
Naproxen Liquid Gel CapsulesMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Preferred Plus Sinus and Cold DKinray
Sinus and Cold DL. Perrigo Company
Sudafed 12 Hour Pressure and PainJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Sunmark Sinus and Cold DMc Kesson
TheraproxenPhysician Therapeutics Llc
Theraproxen-500Physician Therapeutics Llc
Theraproxen-90Physician Therapeutics Llc
Topcare Sinus and Cold DTopco Associates LLC
TreximetGlaxo Smith Kline Llc
Up and Up Sinus and Cold DTarget Corporation
VimovoAstra Zeneca Lp
Salts
Name/CASStructureProperties
Naproxen sodium
ThumbNot applicableDBSALT000949
Categories
UNII57Y76R9ATQ
CAS number22204-53-1
WeightAverage: 230.2592
Monoisotopic: 230.094294314
Chemical FormulaC14H14O3
InChI KeyCMWTZPSULFXXJA-VIFPVBQESA-N
InChI
InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
IUPAC Name
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
SMILES
COC1=CC2=C(C=C1)C=C(C=C2)[[email protected]](C)C(O)=O
Pharmacology
IndicationFor the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea.
Structured Indications
PharmacodynamicsNaproxen is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen has analgesic and antipyretic properties. As with other NSAIDs, its mode of action is not fully understood; however, its ability to inhibit prostaglandin synthesis may be involved in the anti-inflammatory effect.
Mechanism of actionThe mechanism of action of naproxen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.
TargetKindPharmacological actionActionsOrganismUniProt ID
Prostaglandin G/H synthase 1Proteinyes
inhibitor
HumanP23219 details
Prostaglandin G/H synthase 2Proteinyes
inhibitor
HumanP35354 details
Peptostreptococcal albumin-binding proteinProteinunknownNot AvailablePeptostreptococcus magnusQ51911 details
Related Articles
AbsorptionNaproxen itself is rapidly and completely absorbed from the GI tract with an in vivo bioavailability of 95%. Although naproxen itself is well absorbed, the sodium salt form is more rapidly absorbed resulting in higher peak plasma levels for a given dose. Food causes a slight decrease in the rate absorption.
Volume of distributionNot Available
Protein bindingAt therapeutic levels naproxen is greater than 99% albumin-bound.
Metabolism

Naproxen is extensively metabolized to 6-0-desmethyl naproxen and both parent and metabolites do not induce metabolizing enzymes.

SubstrateEnzymesProduct
Naproxen
O-DesmethylnaproxenDetails
Naproxen
Naproxen O-glucuronideDetails
O-Desmethylnaproxen
O-Desmethylnaproxen sulfateDetails
O-Desmethylnaproxen
O-Desmethylnaproxen acyl glucuronideDetails
O-Desmethylnaproxen
O-Desmethylnaproxen O-glucuronideDetails
Route of eliminationNot Available
Half lifeThe observed terminal elimination half-life is approximately 15 hours.
ClearanceNot Available
ToxicityORAL (LD50): Acute: 248 mg/kg [Rat]. 360 mg/kg [Mouse]. Symptoms of overdose include drowsiness, heartburn, indigestion, nausea, and vomiting.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Naproxen Action PathwayDrug actionSMP00120
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when Naproxen is combined with 16-Bromoepiandrosterone.Investigational
19-norandrostenedioneThe risk or severity of adverse effects can be increased when Naproxen is combined with 19-norandrostenedione.Experimental, Illicit
4-AndrostenedioneThe risk or severity of adverse effects can be increased when Naproxen is combined with 4-Androstenedione.Experimental, Illicit
5-androstenedioneThe risk or severity of adverse effects can be increased when Naproxen is combined with 5-androstenedione.Experimental, Illicit
AbciximabNaproxen may increase the anticoagulant activities of Abciximab.Approved
AbirateroneThe serum concentration of Naproxen can be increased when it is combined with Abiraterone.Approved
AcebutololNaproxen may decrease the antihypertensive activities of Acebutolol.Approved
AceclofenacThe risk or severity of adverse effects can be increased when Naproxen is combined with Aceclofenac.Approved
AcenocoumarolNaproxen may increase the anticoagulant activities of Acenocoumarol.Approved
AcetovanilloneThe risk or severity of adverse effects can be increased when Naproxen is combined with Acetovanillone.Investigational
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Naproxen is combined with Acetylsalicylic acid.Approved, Vet Approved
AclarubicinNaproxen may decrease the excretion rate of Aclarubicin which could result in a higher serum level.Investigational
AdapaleneThe risk or severity of adverse effects can be increased when Adapalene is combined with Naproxen.Approved
AlclometasoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Alclometasone.Approved
AldosteroneThe risk or severity of adverse effects can be increased when Naproxen is combined with Aldosterone.Experimental
Alendronic acidThe risk or severity of adverse effects can be increased when Naproxen is combined with Alendronic acid.Approved
AliskirenNaproxen may decrease the antihypertensive activities of Aliskiren.Approved, Investigational
AlprenololNaproxen may decrease the antihypertensive activities of Alprenolol.Approved, Withdrawn
AlprostadilThe therapeutic efficacy of Alprostadil can be decreased when used in combination with Naproxen.Approved, Investigational
AmcinonideThe risk or severity of adverse effects can be increased when Naproxen is combined with Amcinonide.Approved
AmikacinNaproxen may decrease the excretion rate of Amikacin which could result in a higher serum level.Approved, Vet Approved
AmilorideNaproxen may decrease the antihypertensive activities of Amiloride.Approved
AmiodaroneThe metabolism of Naproxen can be decreased when combined with Amiodarone.Approved, Investigational
AmrubicinNaproxen may decrease the excretion rate of Amrubicin which could result in a higher serum level.Approved, Investigational
AncrodNaproxen may increase the anticoagulant activities of Ancrod.Investigational
AnecortaveThe risk or severity of adverse effects can be increased when Naproxen is combined with Anecortave.Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Naproxen is combined with Anisodamine.Investigational
annamycinNaproxen may decrease the excretion rate of annamycin which could result in a higher serum level.Investigational
AntipyrineThe risk or severity of adverse effects can be increased when Naproxen is combined with Antipyrine.Approved
Antithrombin III humanNaproxen may increase the anticoagulant activities of Antithrombin III human.Approved
Aop200704Naproxen may decrease the antihypertensive activities of Aop200704.Investigational
ApixabanThe risk or severity of adverse effects can be increased when Naproxen is combined with Apixaban.Approved
ApramycinNaproxen may decrease the excretion rate of Apramycin which could result in a higher serum level.Experimental, Vet Approved
ApremilastThe risk or severity of adverse effects can be increased when Naproxen is combined with Apremilast.Approved, Investigational
AprepitantThe metabolism of Naproxen can be increased when combined with Aprepitant.Approved, Investigational
ArbekacinNaproxen may decrease the excretion rate of Arbekacin which could result in a higher serum level.Approved
ArdeparinNaproxen may increase the anticoagulant activities of Ardeparin.Approved, Withdrawn
ArgatrobanNaproxen may increase the anticoagulant activities of Argatroban.Approved, Investigational
ArotinololNaproxen may decrease the antihypertensive activities of Arotinolol.Approved
AtenololNaproxen may decrease the antihypertensive activities of Atenolol.Approved
AzapropazoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Azapropazone.Withdrawn
AzelastineThe risk or severity of adverse effects can be increased when Naproxen is combined with Azelastine.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Naproxen.Approved
AzithromycinThe metabolism of Naproxen can be decreased when combined with Azithromycin.Approved
BalsalazideNaproxen may increase the nephrotoxic activities of Balsalazide.Approved, Investigational
BecaplerminNaproxen may increase the anticoagulant activities of Becaplermin.Approved, Investigational
BeclomethasoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Beclomethasone.Investigational
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Naproxen is combined with Beclomethasone dipropionate.Approved, Investigational
BefunololNaproxen may decrease the antihypertensive activities of Befunolol.Experimental
BenazeprilThe risk or severity of adverse effects can be increased when Benazepril is combined with Naproxen.Approved, Investigational
BendroflumethiazideThe therapeutic efficacy of Bendroflumethiazide can be decreased when used in combination with Naproxen.Approved
BenoxaprofenThe risk or severity of adverse effects can be increased when Naproxen is combined with Benoxaprofen.Withdrawn
BeraprostThe therapeutic efficacy of Beraprost can be decreased when used in combination with Naproxen.Investigational
BetamethasoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Betamethasone.Approved, Vet Approved
BetaxololNaproxen may decrease the antihypertensive activities of Betaxolol.Approved
Betulinic AcidThe risk or severity of adverse effects can be increased when Naproxen is combined with Betulinic Acid.Investigational
BevantololNaproxen may decrease the antihypertensive activities of Bevantolol.Approved
BimatoprostThe therapeutic efficacy of Bimatoprost can be decreased when used in combination with Naproxen.Approved, Investigational
BisoprololNaproxen may decrease the antihypertensive activities of Bisoprolol.Approved
BivalirudinNaproxen may increase the anticoagulant activities of Bivalirudin.Approved, Investigational
BopindololNaproxen may decrease the antihypertensive activities of Bopindolol.Approved
BortezomibThe metabolism of Naproxen can be decreased when combined with Bortezomib.Approved, Investigational
BromfenacThe risk or severity of adverse effects can be increased when Naproxen is combined with Bromfenac.Approved
BucillamineThe risk or severity of adverse effects can be increased when Naproxen is combined with Bucillamine.Investigational
BucindololNaproxen may decrease the antihypertensive activities of Bucindolol.Investigational
BudesonideThe risk or severity of adverse effects can be increased when Naproxen is combined with Budesonide.Approved
BufuralolNaproxen may decrease the antihypertensive activities of Bufuralol.Experimental, Investigational
BumetanideNaproxen may decrease the diuretic activities of Bumetanide.Approved
BupranololNaproxen may decrease the antihypertensive activities of Bupranolol.Approved
CaffeineThe metabolism of Naproxen can be decreased when combined with Caffeine.Approved
CandesartanThe risk or severity of adverse effects can be increased when Candesartan is combined with Naproxen.Approved
CandoxatrilThe risk or severity of adverse effects can be increased when Candoxatril is combined with Naproxen.Experimental
CapecitabineThe metabolism of Naproxen can be decreased when combined with Capecitabine.Approved, Investigational
CaptoprilThe risk or severity of adverse effects can be increased when Captopril is combined with Naproxen.Approved
CarbamazepineThe metabolism of Naproxen can be increased when combined with Carbamazepine.Approved, Investigational
Carboprost TromethamineThe therapeutic efficacy of Carboprost Tromethamine can be decreased when used in combination with Naproxen.Approved
CarprofenThe risk or severity of adverse effects can be increased when Naproxen is combined with Carprofen.Approved, Vet Approved, Withdrawn
CarteololNaproxen may decrease the antihypertensive activities of Carteolol.Approved
CarvedilolNaproxen may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
CastanospermineThe risk or severity of adverse effects can be increased when Naproxen is combined with Castanospermine.Experimental
CelecoxibThe risk or severity of adverse effects can be increased when Naproxen is combined with Celecoxib.Approved, Investigational
CeliprololNaproxen may decrease the antihypertensive activities of Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Naproxen can be increased when it is combined with Ceritinib.Approved
CertoparinNaproxen may increase the anticoagulant activities of Certoparin.Approved
ChloroquineThe risk or severity of adverse effects can be increased when Chloroquine is combined with Naproxen.Approved, Vet Approved
ChlorothiazideThe therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Naproxen.Approved, Vet Approved
ChlorthalidoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Naproxen.Approved
CholecalciferolThe metabolism of Naproxen can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CholestyramineCholestyramine can cause a decrease in the absorption of Naproxen resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CiclesonideThe risk or severity of adverse effects can be increased when Naproxen is combined with Ciclesonide.Approved, Investigational
CilazaprilThe risk or severity of adverse effects can be increased when Cilazapril is combined with Naproxen.Approved
CinoxacinNaproxen may increase the neuroexcitatory activities of Cinoxacin.Approved, Withdrawn
CiprofloxacinNaproxen may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
CitalopramThe metabolism of Naproxen can be decreased when combined with Citalopram.Approved
Citric AcidNaproxen may increase the anticoagulant activities of Citric Acid.Nutraceutical, Vet Approved
ClobetasolThe risk or severity of adverse effects can be increased when Naproxen is combined with Clobetasol.Investigational
Clobetasol propionateThe risk or severity of adverse effects can be increased when Naproxen is combined with Clobetasol propionate.Approved
ClocortoloneThe risk or severity of adverse effects can be increased when Naproxen is combined with Clocortolone.Approved
ClodronateThe risk or severity of adverse effects can be increased when Naproxen is combined with Clodronate.Approved, Investigational, Vet Approved
ClonixinThe risk or severity of adverse effects can be increased when Naproxen is combined with Clonixin.Approved
ClopidogrelThe metabolism of Naproxen can be decreased when combined with Clopidogrel.Approved, Nutraceutical
CloprostenolThe therapeutic efficacy of Cloprostenol can be decreased when used in combination with Naproxen.Vet Approved
ClotrimazoleThe metabolism of Naproxen can be decreased when combined with Clotrimazole.Approved, Vet Approved
ColesevelamColesevelam can cause a decrease in the absorption of Naproxen resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Naproxen resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Cortisone acetateThe risk or severity of adverse effects can be increased when Naproxen is combined with Cortisone acetate.Approved
CurcuminThe risk or severity of adverse effects can be increased when Naproxen is combined with Curcumin.Investigational
CyclosporineNaproxen may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CyclosporineThe metabolism of Naproxen can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Naproxen can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
D-LimoneneThe risk or severity of adverse effects can be increased when Naproxen is combined with D-Limonene.Investigational
Dabigatran etexilateNaproxen may increase the anticoagulant activities of Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Naproxen can be decreased when it is combined with Dabrafenib.Approved
DalteparinNaproxen may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidNaproxen may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DaunorubicinNaproxen may decrease the excretion rate of Daunorubicin which could result in a higher serum level.Approved
DeferasiroxThe serum concentration of Naproxen can be increased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe risk or severity of adverse effects can be increased when Naproxen is combined with dehydroepiandrosterone sulfate.Investigational
DelavirdineThe metabolism of Naproxen can be decreased when combined with Delavirdine.Approved
DesirudinNaproxen may increase the anticoagulant activities of Desirudin.Approved
DesmopressinThe risk or severity of adverse effects can be increased when Naproxen is combined with Desmopressin.Approved
DesoximetasoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Desoximetasone.Approved
Desoxycorticosterone acetateThe risk or severity of adverse effects can be increased when Naproxen is combined with Desoxycorticosterone acetate.Approved
Desoxycorticosterone PivalateThe risk or severity of adverse effects can be increased when Naproxen is combined with Desoxycorticosterone Pivalate.Experimental, Vet Approved
DexamethasoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Dexamethasone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe risk or severity of adverse effects can be increased when Naproxen is combined with Dexamethasone isonicotinate.Vet Approved
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Naproxen.Approved
DextranNaproxen may increase the anticoagulant activities of Dextran.Approved, Vet Approved
Dextran 40Naproxen may increase the anticoagulant activities of Dextran 40.Approved
Dextran 70Naproxen may increase the anticoagulant activities of Dextran 70.Approved
Dextran 75Naproxen may increase the anticoagulant activities of Dextran 75.Approved
DiclofenacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Naproxen.Approved, Vet Approved
DicoumarolNaproxen may increase the anticoagulant activities of Dicoumarol.Approved
DiflorasoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Diflorasone.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Naproxen is combined with Diflunisal.Approved
DifluocortoloneThe risk or severity of adverse effects can be increased when Naproxen is combined with Difluocortolone.Approved
DifluprednateThe risk or severity of adverse effects can be increased when Naproxen is combined with Difluprednate.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Naproxen.Approved
DihydrostreptomycinNaproxen may decrease the excretion rate of Dihydrostreptomycin which could result in a higher serum level.Vet Approved
DinoprostThe therapeutic efficacy of Dinoprost can be decreased when used in combination with Naproxen.Investigational
Dinoprost TromethamineThe therapeutic efficacy of Dinoprost Tromethamine can be decreased when used in combination with Naproxen.Approved, Vet Approved
DinoprostoneThe therapeutic efficacy of Dinoprostone can be decreased when used in combination with Naproxen.Approved
DoxorubicinNaproxen may decrease the excretion rate of Doxorubicin which could result in a higher serum level.Approved, Investigational
DrospirenoneNaproxen may increase the hyperkalemic activities of Drospirenone.Approved
DroxicamThe risk or severity of adverse effects can be increased when Naproxen is combined with Droxicam.Approved
DuvelisibThe risk or severity of adverse effects can be increased when Naproxen is combined with Duvelisib.Investigational
E6201The risk or severity of adverse effects can be increased when Naproxen is combined with E6201.Investigational
EbselenThe risk or severity of adverse effects can be increased when Naproxen is combined with Ebselen.Investigational
Edetic AcidNaproxen may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanNaproxen may increase the anticoagulant activities of Edoxaban.Approved
EfavirenzThe metabolism of Naproxen can be decreased when combined with Efavirenz.Approved, Investigational
EnalaprilThe risk or severity of adverse effects can be increased when Enalapril is combined with Naproxen.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Enalaprilat is combined with Naproxen.Approved
EnoxacinNaproxen may increase the neuroexcitatory activities of Enoxacin.Approved
EnoxaparinNaproxen may increase the anticoagulant activities of Enoxaparin.Approved
EpirizoleThe risk or severity of adverse effects can be increased when Naproxen is combined with Epirizole.Approved
EpirubicinNaproxen may decrease the excretion rate of Epirubicin which could result in a higher serum level.Approved
EplerenoneNaproxen may decrease the antihypertensive activities of Eplerenone.Approved
EpoprostenolThe therapeutic efficacy of Epoprostenol can be decreased when used in combination with Naproxen.Approved
EprosartanThe risk or severity of adverse effects can be increased when Eprosartan is combined with Naproxen.Approved
EquileninThe risk or severity of adverse effects can be increased when Naproxen is combined with Equilenin.Experimental
EquilinThe risk or severity of adverse effects can be increased when Naproxen is combined with Equilin.Approved
EsmololNaproxen may decrease the antihypertensive activities of Esmolol.Approved
EstroneThe risk or severity of adverse effects can be increased when Naproxen is combined with Estrone.Approved
Estrone sulfateThe risk or severity of adverse effects can be increased when Naproxen is combined with Estrone sulfate.Approved
Etacrynic acidNaproxen may decrease the diuretic activities of Etacrynic acid.Approved
EtanerceptThe risk or severity of adverse effects can be increased when Etanercept is combined with Naproxen.Approved, Investigational
Ethyl biscoumacetateNaproxen may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Etidronic acidThe risk or severity of adverse effects can be increased when Naproxen is combined with Etidronic acid.Approved
EtodolacThe risk or severity of adverse effects can be increased when Naproxen is combined with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Naproxen is combined with Etofenamate.Approved
EtoricoxibThe risk or severity of adverse effects can be increased when Naproxen is combined with Etoricoxib.Approved, Investigational
EtravirineThe metabolism of Naproxen can be decreased when combined with Etravirine.Approved
Evening primrose oilThe risk or severity of adverse effects can be increased when Naproxen is combined with Evening primrose oil.Approved
exisulindThe risk or severity of adverse effects can be increased when Naproxen is combined with exisulind.Investigational
FelodipineThe metabolism of Naproxen can be decreased when combined with Felodipine.Approved, Investigational
FenbufenThe risk or severity of adverse effects can be increased when Naproxen is combined with Fenbufen.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Fenoprofen is combined with Naproxen.Approved
FenprostaleneThe therapeutic efficacy of Fenprostalene can be decreased when used in combination with Naproxen.Vet Approved
FleroxacinNaproxen may increase the neuroexcitatory activities of Fleroxacin.Approved
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Naproxen.Approved, Withdrawn
FloxuridineThe metabolism of Naproxen can be decreased when combined with Floxuridine.Approved
fluasteroneThe risk or severity of adverse effects can be increased when Naproxen is combined with fluasterone.Investigational
FluconazoleThe metabolism of Naproxen can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Fludrocortisone.Approved
FluindioneNaproxen may increase the anticoagulant activities of Fluindione.Investigational
FlumequineNaproxen may increase the neuroexcitatory activities of Flumequine.Withdrawn
FlumethasoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Flumethasone.Approved, Vet Approved
FlunisolideThe risk or severity of adverse effects can be increased when Naproxen is combined with Flunisolide.Approved, Investigational
FlunixinThe risk or severity of adverse effects can be increased when Naproxen is combined with Flunixin.Vet Approved
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Naproxen is combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluocinonideThe risk or severity of adverse effects can be increased when Naproxen is combined with Fluocinonide.Approved, Investigational
FluocortoloneThe risk or severity of adverse effects can be increased when Naproxen is combined with Fluocortolone.Approved, Withdrawn
FluorometholoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Fluorometholone.Approved
FluorouracilThe metabolism of Naproxen can be decreased when combined with Fluorouracil.Approved
FluprednideneThe risk or severity of adverse effects can be increased when Naproxen is combined with Fluprednidene.Approved, Withdrawn
FluprednisoloneThe risk or severity of adverse effects can be increased when Naproxen is combined with Fluprednisolone.Approved
FluprostenolThe therapeutic efficacy of Fluprostenol can be decreased when used in combination with Naproxen.Vet Approved
FlurandrenolideThe risk or severity of adverse effects can be increased when Naproxen is combined with Flurandrenolide.Approved
FlurbiprofenThe risk or severity of adverse effects can be increased when Flurbiprofen is combined with Naproxen.Approved, Investigational
Fluticasone furoateThe risk or severity of adverse effects can be increased when Naproxen is combined with Fluticasone furoate.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Naproxen is combined with Fluticasone Propionate.Approved
FluvastatinThe metabolism of Naproxen can be decreased when combined with Fluvastatin.Approved
FluvoxamineThe metabolism of Naproxen can be decreased when combined with Fluvoxamine.Approved, Investigational
Folic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Naproxen.Approved, Nutraceutical, Vet Approved
FondaparinuxNaproxen may increase the anticoagulant activities of Fondaparinux.Investigational
Fondaparinux sodiumNaproxen may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Naproxen.Experimental
FormestaneThe risk or severity of adverse effects can be increased when Naproxen is combined with Formestane.Approved, Investigational, Withdrawn
FosinoprilThe risk or severity of adverse effects can be increased when Fosinopril is combined with Naproxen.Approved
FosphenytoinThe metabolism of Naproxen can be increased when combined with Fosphenytoin.Approved
FramycetinNaproxen may decrease the excretion rate of Framycetin which could result in a higher serum level.Approved
FurosemideNaproxen may decrease the diuretic activities of Furosemide.Approved, Vet Approved
GabexateNaproxen may increase the anticoagulant activities of Gabexate.Investigational
GarenoxacinNaproxen may increase the neuroexcitatory activities of Garenoxacin.Investigational
GatifloxacinNaproxen may increase the neuroexcitatory activities of Gatifloxacin.Approved, Investigational
GemeprostThe therapeutic efficacy of Gemeprost can be decreased when used in combination with Naproxen.Approved, Withdrawn
GemfibrozilThe metabolism of Naproxen can be decreased when combined with Gemfibrozil.Approved
GemifloxacinNaproxen may increase the neuroexcitatory activities of Gemifloxacin.Approved, Investigational
GeneticinNaproxen may decrease the excretion rate of Geneticin which could result in a higher serum level.Experimental
GentamicinNaproxen may decrease the excretion rate of Gentamicin which could result in a higher serum level.Approved, Vet Approved
GENTAMICIN C1ANaproxen may decrease the excretion rate of GENTAMICIN C1A which could result in a higher serum level.Experimental
GrepafloxacinNaproxen may increase the neuroexcitatory activities of Grepafloxacin.Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Naproxen is combined with Haloperidol.Approved
HE3286The risk or severity of adverse effects can be increased when Naproxen is combined with HE3286.Investigational
HeparinNaproxen may increase the anticoagulant activities of Heparin.Approved, Investigational
HigenamineThe risk or severity of adverse effects can be increased when Naproxen is combined with Higenamine.Investigational
HirulogNaproxen may increase the anticoagulant activities of Hirulog.Experimental
HMPL-004The risk or severity of adverse effects can be increased when Naproxen is combined with HMPL-004.Investigational
HydralazineNaproxen may decrease the antihypertensive activities of Hydralazine.Approved
HydrochlorothiazideThe therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Naproxen.Approved, Vet Approved
HydrocortisoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Hydrocortisone.Approved, Vet Approved
HydroflumethiazideThe therapeutic efficacy of Hydroflumethiazide can be decreased when used in combination with Naproxen.Approved
Hygromycin BNaproxen may decrease the excretion rate of Hygromycin B which could result in a higher serum level.Vet Approved
IbandronateThe risk or severity of adverse effects can be increased when Naproxen is combined with Ibandronate.Approved, Investigational
IbuprofenThe risk or severity of adverse effects can be increased when Naproxen is combined with Ibuprofen.Approved
IbuproxamThe risk or severity of adverse effects can be increased when Naproxen is combined with Ibuproxam.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Naproxen is combined with Icatibant.Approved
IdarubicinNaproxen may decrease the excretion rate of Idarubicin which could result in a higher serum level.Approved
idraparinuxNaproxen may increase the anticoagulant activities of idraparinux.Investigational
IloprostThe therapeutic efficacy of Iloprost can be decreased when used in combination with Naproxen.Approved, Investigational
ImidaprilThe risk or severity of adverse effects can be increased when Imidapril is combined with Naproxen.Investigational
IndapamideThe therapeutic efficacy of Indapamide can be decreased when used in combination with Naproxen.Approved
IndenololNaproxen may decrease the antihypertensive activities of Indenolol.Withdrawn
IndinavirThe metabolism of Naproxen can be decreased when combined with Indinavir.Approved
IndomethacinThe risk or severity of adverse effects can be increased when Indomethacin is combined with Naproxen.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Naproxen is combined with Indoprofen.Withdrawn
INNO-206Naproxen may decrease the excretion rate of INNO-206 which could result in a higher serum level.Investigational
IrbesartanThe metabolism of Naproxen can be decreased when combined with Irbesartan.Approved, Investigational
IsoxicamThe risk or severity of adverse effects can be increased when Naproxen is combined with Isoxicam.Withdrawn
IstaroximeThe risk or severity of adverse effects can be increased when Naproxen is combined with Istaroxime.Investigational
KanamycinNaproxen may decrease the excretion rate of Kanamycin which could result in a higher serum level.Approved, Vet Approved
KebuzoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Kebuzone.Experimental
KetoconazoleThe metabolism of Naproxen can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenThe risk or severity of adverse effects can be increased when Naproxen is combined with Ketoprofen.Approved, Vet Approved
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Naproxen.Approved
LabetalolNaproxen may decrease the antihypertensive activities of Labetalol.Approved
LapatinibThe metabolism of Naproxen can be decreased when combined with Lapatinib.Approved, Investigational
LatanoprostThe therapeutic efficacy of Latanoprost can be decreased when used in combination with Naproxen.Approved, Investigational
LeflunomideThe metabolism of Naproxen can be decreased when combined with Leflunomide.Approved, Investigational
LepirudinNaproxen may increase the anticoagulant activities of Lepirudin.Approved
LevobunololNaproxen may decrease the antihypertensive activities of Levobunolol.Approved
LevofloxacinNaproxen may increase the neuroexcitatory activities of Levofloxacin.Approved, Investigational
LidocaineThe metabolism of Naproxen can be decreased when combined with Lidocaine.Approved, Vet Approved
LimaprostThe therapeutic efficacy of Limaprost can be decreased when used in combination with Naproxen.Approved
LisinoprilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Naproxen.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Naproxen is combined with Lisofylline.Investigational
LithiumThe serum concentration of Lithium can be increased when it is combined with Naproxen.Approved
LomefloxacinNaproxen may increase the neuroexcitatory activities of Lomefloxacin.Approved
LopinavirThe metabolism of Naproxen can be decreased when combined with Lopinavir.Approved
LornoxicamThe risk or severity of adverse effects can be increased when Naproxen is combined with Lornoxicam.Approved
LosartanThe metabolism of Naproxen can be decreased when combined with Losartan.Approved
LovastatinThe metabolism of Naproxen can be decreased when combined with Lovastatin.Approved, Investigational
LoxoprofenThe risk or severity of adverse effects can be increased when Naproxen is combined with Loxoprofen.Approved
LubiprostoneThe therapeutic efficacy of Lubiprostone can be decreased when used in combination with Naproxen.Approved, Investigational
LumacaftorThe serum concentration of Naproxen can be increased when it is combined with Lumacaftor.Approved
LumiracoxibThe risk or severity of adverse effects can be increased when Naproxen is combined with Lumiracoxib.Approved, Investigational
LuprostiolThe therapeutic efficacy of Luprostiol can be decreased when used in combination with Naproxen.Vet Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Naproxen is combined with Magnesium salicylate.Approved
MasoprocolThe risk or severity of adverse effects can be increased when Masoprocol is combined with Naproxen.Approved
ME-609The risk or severity of adverse effects can be increased when Naproxen is combined with ME-609.Investigational
Meclofenamic acidThe risk or severity of adverse effects can be increased when Naproxen is combined with Meclofenamic acid.Approved, Vet Approved
MedrysoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Medrysone.Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Mefenamic acid is combined with Naproxen.Approved
MelengestrolThe risk or severity of adverse effects can be increased when Naproxen is combined with Melengestrol.Vet Approved
MeloxicamThe risk or severity of adverse effects can be increased when Naproxen is combined with Meloxicam.Approved, Vet Approved
MesalazineNaproxen may increase the nephrotoxic activities of Mesalazine.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Naproxen is combined with Metamizole.Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Naproxen.Approved
MethyclothiazideThe therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Naproxen.Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Naproxen is combined with Methylprednisolone.Approved, Vet Approved
MetipranololNaproxen may decrease the antihypertensive activities of Metipranolol.Approved
MetolazoneThe therapeutic efficacy of Metolazone can be decreased when used in combination with Naproxen.Approved
MetoprololNaproxen may decrease the antihypertensive activities of Metoprolol.Approved, Investigational
MetrizamideNaproxen may decrease the excretion rate of Metrizamide which could result in a higher serum level.Approved
MexiletineThe metabolism of Naproxen can be decreased when combined with Mexiletine.Approved
MifepristoneThe serum concentration of Naproxen can be increased when it is combined with Mifepristone.Approved, Investigational
MisoprostolThe therapeutic efficacy of Misoprostol can be decreased when used in combination with Naproxen.Approved
MizoribineThe risk or severity of adverse effects can be increased when Naproxen is combined with Mizoribine.Investigational
MoexiprilThe risk or severity of adverse effects can be increased when Moexipril is combined with Naproxen.Approved
MometasoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Mometasone.Approved, Vet Approved
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Naproxen.Approved
MoxifloxacinNaproxen may increase the neuroexcitatory activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Naproxen.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Naproxen is combined with Mycophenolic acid.Approved
NabumetoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Nabumetone.Approved
NadololNaproxen may decrease the antihypertensive activities of Nadolol.Approved
NadroparinNaproxen may increase the anticoagulant activities of Nadroparin.Approved
NafamostatNaproxen may increase the anticoagulant activities of Nafamostat.Investigational
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Naproxen.Approved
Nalidixic AcidNaproxen may increase the neuroexcitatory activities of Nalidixic Acid.Approved
NCX 1022The risk or severity of adverse effects can be increased when Naproxen is combined with NCX 1022.Investigational
NCX 4016The risk or severity of adverse effects can be increased when Naproxen is combined with NCX 4016.Investigational
NeamineNaproxen may decrease the excretion rate of Neamine which could result in a higher serum level.Experimental
NemonoxacinNaproxen may increase the neuroexcitatory activities of Nemonoxacin.Investigational
NeomycinNaproxen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
NepafenacThe risk or severity of adverse effects can be increased when Naproxen is combined with Nepafenac.Approved
NetilmicinNaproxen may decrease the excretion rate of Netilmicin which could result in a higher serum level.Approved
NevirapineThe metabolism of Naproxen can be decreased when combined with Nevirapine.Approved
NicardipineThe metabolism of Naproxen can be decreased when combined with Nicardipine.Approved
Niflumic AcidThe risk or severity of adverse effects can be increased when Naproxen is combined with Niflumic Acid.Approved
NilotinibThe metabolism of Naproxen can be decreased when combined with Nilotinib.Approved, Investigational
NimesulideThe risk or severity of adverse effects can be increased when Naproxen is combined with Nimesulide.Approved, Withdrawn
NitroaspirinThe risk or severity of adverse effects can be increased when Naproxen is combined with Nitroaspirin.Investigational
NorfloxacinNaproxen may increase the neuroexcitatory activities of Norfloxacin.Approved
OfloxacinNaproxen may increase the neuroexcitatory activities of Ofloxacin.Approved
Oleoyl estroneThe risk or severity of adverse effects can be increased when Naproxen is combined with Oleoyl estrone.Investigational
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Naproxen.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Naproxen.Approved
OlsalazineNaproxen may increase the nephrotoxic activities of Olsalazine.Approved
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Naproxen is combined with Omacetaxine mepesuccinate.Approved
OmapatrilatThe risk or severity of adverse effects can be increased when Omapatrilat is combined with Naproxen.Investigational
OmeprazoleThe metabolism of Naproxen can be decreased when combined with Omeprazole.Approved, Investigational, Vet Approved
OrgoteinThe risk or severity of adverse effects can be increased when Naproxen is combined with Orgotein.Vet Approved
OsimertinibThe serum concentration of Naproxen can be decreased when it is combined with Osimertinib.Approved
OtamixabanNaproxen may increase the anticoagulant activities of Otamixaban.Investigational
OxaprozinThe risk or severity of adverse effects can be increased when Naproxen is combined with Oxaprozin.Approved
OxprenololNaproxen may decrease the antihypertensive activities of Oxprenolol.Approved
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Oxyphenbutazone.Withdrawn
PamidronateThe risk or severity of adverse effects can be increased when Naproxen is combined with Pamidronate.Approved
ParamethasoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Paramethasone.Approved
ParecoxibThe risk or severity of adverse effects can be increased when Naproxen is combined with Parecoxib.Approved
ParomomycinNaproxen may decrease the excretion rate of Paromomycin which could result in a higher serum level.Approved, Investigational
PazufloxacinNaproxen may increase the neuroexcitatory activities of Pazufloxacin.Investigational
PefloxacinNaproxen may increase the neuroexcitatory activities of Pefloxacin.Approved
Peginterferon alfa-2bThe serum concentration of Naproxen can be increased when it is combined with Peginterferon alfa-2b.Approved
PenbutololNaproxen may decrease the antihypertensive activities of Penbutolol.Approved, Investigational
Pentosan PolysulfateNaproxen may increase the anticoagulant activities of Pentosan Polysulfate.Approved
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Naproxen.Approved
PhenindioneNaproxen may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe metabolism of Naproxen can be increased when combined with Phenobarbital.Approved
PhenprocoumonNaproxen may increase the anticoagulant activities of Phenprocoumon.Approved
PhenylbutazoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Phenylbutazone.Approved, Vet Approved
PhenytoinThe metabolism of Naproxen can be increased when combined with Phenytoin.Approved, Vet Approved
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Naproxen.Approved, Investigational
PindololNaproxen may decrease the antihypertensive activities of Pindolol.Approved
PioglitazoneThe metabolism of Naproxen can be decreased when combined with Pioglitazone.Approved, Investigational
PirarubicinNaproxen may decrease the excretion rate of Pirarubicin which could result in a higher serum level.Investigational
PiretanideNaproxen may decrease the diuretic activities of Piretanide.Experimental
PirfenidoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Pirfenidone.Investigational
PiroxicamThe risk or severity of adverse effects can be increased when Piroxicam is combined with Naproxen.Approved, Investigational
PlicamycinNaproxen may decrease the excretion rate of Plicamycin which could result in a higher serum level.Approved, Withdrawn
PolythiazideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Naproxen.Approved
PractololNaproxen may decrease the antihypertensive activities of Practolol.Approved
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Naproxen.Approved
PrasteroneThe risk or severity of adverse effects can be increased when Naproxen is combined with Prasterone.Approved, Nutraceutical
PrednicarbateThe risk or severity of adverse effects can be increased when Naproxen is combined with Prednicarbate.Approved
PrednisoloneThe risk or severity of adverse effects can be increased when Naproxen is combined with Prednisolone.Approved, Vet Approved
PrednisoneThe risk or severity of adverse effects can be increased when Naproxen is combined with Prednisone.Approved, Vet Approved
PregnenoloneThe risk or severity of adverse effects can be increased when Naproxen is combined with Pregnenolone.Experimental
PrimidoneThe metabolism of Naproxen can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Naproxen can be increased when it is combined with Probenecid.Approved
PropacetamolThe risk or severity of adverse effects can be increased when Naproxen is combined with Propacetamol.Approved
PropranololNaproxen may decrease the antihypertensive activities of Propranolol.Approved, Investigational
Prostaglandin B2The therapeutic efficacy of Prostaglandin B2 can be decreased when used in combination with Naproxen.Experimental
Prostaglandin D2The therapeutic efficacy of Prostaglandin D2 can be decreased when used in combination with Naproxen.Experimental, Investigational
Prostaglandin G2The therapeutic efficacy of Prostaglandin G2 can be decreased when used in combination with Naproxen.Experimental
ProstaleneThe therapeutic efficacy of Prostalene can be decreased when used in combination with Naproxen.Vet Approved
Protein CNaproxen may increase the anticoagulant activities of Protein C.Approved
Protein S humanNaproxen may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeNaproxen may increase the anticoagulant activities of Protocatechualdehyde.Approved
PrulifloxacinNaproxen may increase the neuroexcitatory activities of Prulifloxacin.Investigational
PTC299The risk or severity of adverse effects can be increased when Naproxen is combined with PTC299.Investigational
PuromycinNaproxen may decrease the excretion rate of Puromycin which could result in a higher serum level.Experimental
PyrimethamineThe metabolism of Naproxen can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuinaprilThe risk or severity of adverse effects can be increased when Quinapril is combined with Naproxen.Approved, Investigational
QuinethazoneThe therapeutic efficacy of Quinethazone can be decreased when used in combination with Naproxen.Approved
QuinineThe metabolism of Naproxen can be decreased when combined with Quinine.Approved
RabeprazoleThe metabolism of Naproxen can be decreased when combined with Rabeprazole.Approved, Investigational
RamiprilThe risk or severity of adverse effects can be increased when Ramipril is combined with Naproxen.Approved
RescinnamineThe risk or severity of adverse effects can be increased when Rescinnamine is combined with Naproxen.Approved
ResveratrolThe risk or severity of adverse effects can be increased when Naproxen is combined with Resveratrol.Experimental, Investigational
ReviparinNaproxen may increase the anticoagulant activities of Reviparin.Approved
RibostamycinNaproxen may decrease the excretion rate of Ribostamycin which could result in a higher serum level.Approved
RifampicinThe metabolism of Naproxen can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Naproxen can be increased when combined with Rifapentine.Approved
RimexoloneThe risk or severity of adverse effects can be increased when Naproxen is combined with Rimexolone.Approved
RisedronateThe risk or severity of adverse effects can be increased when Naproxen is combined with Risedronate.Approved, Investigational
RitonavirThe metabolism of Naproxen can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanNaproxen may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibThe risk or severity of adverse effects can be increased when Naproxen is combined with Rofecoxib.Investigational, Withdrawn
RopiniroleThe metabolism of Naproxen can be decreased when combined with Ropinirole.Approved, Investigational
RosiglitazoneThe metabolism of Naproxen can be decreased when combined with Rosiglitazone.Approved, Investigational
RosoxacinNaproxen may increase the neuroexcitatory activities of Rosoxacin.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Naproxen.Approved
SalicylamideThe risk or severity of adverse effects can be increased when Naproxen is combined with Salicylamide.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Naproxen is combined with Salicylic acid.Approved, Vet Approved
SalsalateThe risk or severity of adverse effects can be increased when Naproxen is combined with Salsalate.Approved
SaprisartanThe risk or severity of adverse effects can be increased when Saprisartan is combined with Naproxen.Experimental
SaralasinThe risk or severity of adverse effects can be increased when Saralasin is combined with Naproxen.Investigational
SecobarbitalThe metabolism of Naproxen can be increased when combined with Secobarbital.Approved, Vet Approved
SeratrodastThe risk or severity of adverse effects can be increased when Naproxen is combined with Seratrodast.Approved, Investigational
SildenafilThe metabolism of Naproxen can be decreased when combined with Sildenafil.Approved, Investigational
SimeprevirThe metabolism of Naproxen can be decreased when combined with Simeprevir.Approved
SisomicinNaproxen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
SorafenibThe metabolism of Naproxen can be decreased when combined with Sorafenib.Approved, Investigational
SotalolNaproxen may decrease the antihypertensive activities of Sotalol.Approved
SP1049CNaproxen may decrease the excretion rate of SP1049C which could result in a higher serum level.Investigational
SparfloxacinNaproxen may increase the neuroexcitatory activities of Sparfloxacin.Approved
SpectinomycinNaproxen may decrease the excretion rate of Spectinomycin which could result in a higher serum level.Approved, Vet Approved
SpiraprilThe risk or severity of adverse effects can be increased when Spirapril is combined with Naproxen.Approved
SpironolactoneNaproxen may decrease the antihypertensive activities of Spironolactone.Approved
SRT501The risk or severity of adverse effects can be increased when Naproxen is combined with SRT501.Investigational
StiripentolThe metabolism of Naproxen can be decreased when combined with Stiripentol.Approved
StreptomycinNaproxen may decrease the excretion rate of Streptomycin which could result in a higher serum level.Approved, Vet Approved
StreptozocinNaproxen may decrease the excretion rate of Streptozocin which could result in a higher serum level.Approved
SulfadiazineThe metabolism of Naproxen can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Naproxen can be decreased when combined with Sulfamethoxazole.Approved
SulfasalazineNaproxen may increase the nephrotoxic activities of Sulfasalazine.Approved
SulfisoxazoleThe metabolism of Naproxen can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulindacThe risk or severity of adverse effects can be increased when Sulindac is combined with Naproxen.Approved
SulodexideNaproxen may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SulprostoneThe therapeutic efficacy of Sulprostone can be decreased when used in combination with Naproxen.Investigational
SuprofenThe risk or severity of adverse effects can be increased when Naproxen is combined with Suprofen.Approved, Withdrawn
TacrolimusNaproxen may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
TafluprostThe therapeutic efficacy of Tafluprost can be decreased when used in combination with Naproxen.Approved
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Naproxen.Approved
TamoxifenThe metabolism of Naproxen can be decreased when combined with Tamoxifen.Approved
TasosartanThe risk or severity of adverse effects can be increased when Tasosartan is combined with Naproxen.Approved
Technetium tc 99m etidronateThe risk or severity of adverse effects can be increased when Naproxen is combined with Technetium tc 99m etidronate.Approved
Technetium Tc-99m MedronateThe risk or severity of adverse effects can be increased when Naproxen is combined with Technetium Tc-99m Medronate.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Telmisartan is combined with Naproxen.Approved, Investigational
TemafloxacinNaproxen may increase the neuroexcitatory activities of Temafloxacin.Withdrawn
TemocaprilThe risk or severity of adverse effects can be increased when Temocapril is combined with Naproxen.Experimental, Investigational
TenofovirThe risk or severity of adverse effects can be increased when Naproxen is combined with Tenofovir.Approved, Investigational
TenoxicamThe risk or severity of adverse effects can be increased when Tenoxicam is combined with Naproxen.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Naproxen is combined with Tepoxalin.Vet Approved
TeriflunomideThe serum concentration of Naproxen can be decreased when it is combined with Teriflunomide.Approved
TheophyllineThe metabolism of Naproxen can be decreased when combined with Theophylline.Approved
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Naproxen is combined with Tiaprofenic acid.Approved
TicagrelorThe metabolism of Naproxen can be decreased when combined with Ticagrelor.Approved
TiclopidineThe metabolism of Naproxen can be decreased when combined with Ticlopidine.Approved
TiludronateThe risk or severity of adverse effects can be increased when Naproxen is combined with Tiludronate.Approved, Vet Approved
TimololNaproxen may decrease the antihypertensive activities of Timolol.Approved
TinoridineThe risk or severity of adverse effects can be increased when Naproxen is combined with Tinoridine.Investigational
TixocortolThe risk or severity of adverse effects can be increased when Naproxen is combined with Tixocortol.Approved
TobramycinNaproxen may decrease the excretion rate of Tobramycin which could result in a higher serum level.Approved, Investigational
TolbutamideThe metabolism of Naproxen can be decreased when combined with Tolbutamide.Approved
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Naproxen is combined with Tolfenamic Acid.Approved
TolmetinThe risk or severity of adverse effects can be increased when Tolmetin is combined with Naproxen.Approved
TorasemideNaproxen may decrease the diuretic activities of Torasemide.Approved
TrandolaprilThe risk or severity of adverse effects can be increased when Trandolapril is combined with Naproxen.Approved
TranilastThe risk or severity of adverse effects can be increased when Naproxen is combined with Tranilast.Approved, Investigational
TravoprostThe therapeutic efficacy of Travoprost can be decreased when used in combination with Naproxen.Approved
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Naproxen.Approved, Investigational
TriamcinoloneThe risk or severity of adverse effects can be increased when Naproxen is combined with Triamcinolone.Approved, Vet Approved
TriamtereneNaproxen may decrease the antihypertensive activities of Triamterene.Approved
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Naproxen.Approved, Vet Approved
TrimethoprimThe metabolism of Naproxen can be decreased when combined with Trimethoprim.Approved, Vet Approved
Trisalicylate-cholineThe risk or severity of adverse effects can be increased when Naproxen is combined with Trisalicylate-choline.Approved
TrovafloxacinNaproxen may increase the neuroexcitatory activities of Trovafloxacin.Approved, Withdrawn
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Naproxen.Approved
ValdecoxibThe risk or severity of adverse effects can be increased when Naproxen is combined with Valdecoxib.Investigational, Withdrawn
Valproic AcidThe metabolism of Naproxen can be decreased when combined with Valproic Acid.Approved, Investigational
ValrubicinNaproxen may decrease the excretion rate of Valrubicin which could result in a higher serum level.Approved
ValsartanThe metabolism of Naproxen can be decreased when combined with Valsartan.Approved, Investigational
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Naproxen.Approved
VemurafenibThe serum concentration of Naproxen can be increased when it is combined with Vemurafenib.Approved
VoriconazoleThe metabolism of Naproxen can be decreased when combined with Voriconazole.Approved, Investigational
WarfarinNaproxen may increase the anticoagulant activities of Warfarin.Approved
XimelagatranNaproxen may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
Ym150Naproxen may increase the anticoagulant activities of Ym150.Investigational
ZafirlukastThe metabolism of Naproxen can be decreased when combined with Zafirlukast.Approved, Investigational
ZaltoprofenThe risk or severity of adverse effects can be increased when Naproxen is combined with Zaltoprofen.Approved
ZileutonThe risk or severity of adverse effects can be increased when Zileuton is combined with Naproxen.Approved, Investigational, Withdrawn
Zoledronic acidThe risk or severity of adverse effects can be increased when Naproxen is combined with Zoledronic acid.Approved
ZomepiracThe risk or severity of adverse effects can be increased when Naproxen is combined with Zomepirac.Withdrawn
ZorubicinNaproxen may decrease the excretion rate of Zorubicin which could result in a higher serum level.Experimental
Food Interactions
  • Avoid alcohol.
  • Take with a full glass of water.
  • Take with food.
References
Synthesis Reference

DrugSyn.org

US4009197
General References
  1. Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C: Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006 Jun 3;332(7553):1302-8. [PubMed:16740558 ]
  2. Zhang J, Ding EL, Song Y: Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. JAMA. 2006 Oct 4;296(13):1619-32. Epub 2006 Sep 12. [PubMed:16968832 ]
External Links
ATC CodesM01AE52M01AE02M01AE56M02AA12G02CC02
AHFS Codes
  • 28:08.04.92
PDB EntriesNot Available
FDA labelDownload (240 KB)
MSDSDownload (75.4 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9948
Blood Brain Barrier+0.6881
Caco-2 permeable+0.9091
P-glycoprotein substrateNon-substrate0.586
P-glycoprotein inhibitor INon-inhibitor0.8747
P-glycoprotein inhibitor IINon-inhibitor0.8396
Renal organic cation transporterNon-inhibitor0.8615
CYP450 2C9 substrateNon-substrate0.7548
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.5715
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9521
CYP450 2C19 inhibitorNon-inhibitor0.9447
CYP450 3A4 inhibitorNon-inhibitor0.8905
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8598
Ames testAMES toxic0.5184
CarcinogenicityNon-carcinogens0.8685
BiodegradationNot ready biodegradable0.7809
Rat acute toxicity2.4579 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9588
hERG inhibition (predictor II)Non-inhibitor0.9144
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Roche palo alto llc
  • Roxane laboratories inc
  • Actavis elizabeth llc
  • Alphapharm party ltd
  • Pliva inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Amneal pharmaceuticals ny llc
  • Baxter healthcare corp anesthesia and critical care
  • Dava pharmaceuticals inc
  • Glenmark generics ltd
  • Hamilton pharmaceuticals ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Perrigo r and d co
  • Purepac pharmaceutical co
  • Teva pharmaceuticals usa
  • Watson laboratories inc
  • Westward pharmaceutical corp
  • Zydus pharmaceuticals usa inc
  • Banner pharmacaps inc
  • Stat trade inc
  • Watson laboratories inc florida
  • Bayer healthcare llc
  • Able laboratories inc
  • Contract pharmacal corp
  • Dr reddys laboratories inc
  • Dr reddys laboratories ltd
  • Hikma pharmaceuticals
  • L perrigo co
Packagers
Dosage forms
FormRouteStrength
Tablet, coatedOral220 mg/1
CapsuleOral220 mg
TabletOral
TabletOral200 mg/1
TabletOral275 mg/1
TabletOral550 mg/1
TabletOral125 mg
TabletOral250 mg
TabletOral375 mg
TabletOral275 mg
Tablet, extended releaseOral750 mg
CapsuleOral220 mg/1
Tablet, delayed releaseOral375 mg/1
Tablet, delayed releaseOral500 mg/1
KitTopical
Tablet, film coatedOral200 mg/1
Capsule, liquid filledOral220 mg/1
TabletOral220 mg/1
Tablet, film coatedOral220 mg/1
CapsuleOral200 mg
Tablet, delayed releaseOral500 mg
KitOral
Tablet, extended releaseOral375 mg
Tablet, extended releaseOral500 mg
Tablet, film coated, extended releaseOral375 mg/1
Tablet, film coated, extended releaseOral500 mg/1
Tablet, film coated, extended releaseOral750 mg/1
SuspensionOral125 mg/5mL
TabletOral250 mg/1
TabletOral375 mg/1
TabletOral500 mg/1
SuspensionOral25 mg
CapsuleOral500 mg/1
TabletOral220 mg
TabletOral500 mg/500mg
Tablet, film coatedOral275 mg/1
Tablet, film coatedOral550 mg/1
CapsuleOral
Kit
TabletOral200 1/1
Tablet, film coated, extended releaseOral220 mg/1
SuppositoryRectal500 mg
Tablet, film coatedOral
Tablet, film coated, extended releaseOral
TabletOral500 mg
Tablet, delayed releaseOral250 mg
Tablet, delayed releaseOral375 mg
TabletOral550 mg
Kit
Tablet, delayed releaseOral
Prices
Unit descriptionCostUnit
Naproxen 125 mg/5ml Suspension 500ml Bottle51.5USD bottle
Naprelan 750 mg 24 Hour tablet8.87USD tablet
Naprelan cr 500 mg tablet8.5USD tablet
Naprelan cr 750 mg tablet8.02USD tablet
Naprelan cr dosecrd 500-750 mg5.98USD each
Naprelan 375 mg 24 Hour tablet4.34USD tablet
Anaprox ds 550 mg tablet3.66USD tablet
Naprelan 500 mg 24 Hour tablet3.63USD tablet
Naprelan cr 375 mg tablet3.52USD tablet
Naproxen sodium powder2.63USD g
Anaprox 275 mg tablet2.52USD tablet
Naprosyn 500 mg tablet2.42USD tablet
Naproxen powder2.26USD g
Naprosyn 500 mg tablet ec2.19USD tablet
Naprosyn 375 mg tablet1.93USD tablet
Ec-naprosyn 375 mg tablet ec1.79USD tablet
Naprosyn 250 mg tablet1.47USD tablet
Naprosyn Sr 750 mg Sustained-Release Tablet1.43USD tablet
Anaprox Ds 550 mg Tablet1.33USD tablet
Naproxen 500 mg tablet1.32USD tablet
Naproxen sodium 550 mg tablet1.32USD tablet
Naproxen DR 500 mg Enteric Coated Tabs1.3USD tab
Naproxen DR 375 mg Enteric Coated Tabs1.11USD tab
Naprosyn E 500 mg Enteric-Coated Tablet1.09USD tablet
Naproxen 375 mg tablet1.08USD tablet
Apo-Naproxen Sr 750 mg Sustained-Release Tablet1.05USD tablet
Pms-Naproxen 500 mg Suppository0.87USD suppository
Naproxen sodium 275 mg tablet0.86USD tablet
Naproxen 250 mg tablet0.79USD tablet
Apo-Napro-Na Ds 550 mg Tablet0.7USD tablet
Novo-Naprox Sodium Ds 550 mg Tablet0.7USD tablet
Anaprox 275 mg Tablet0.69USD tablet
Apo-Naproxen Ec 500 mg Enteric-Coated Tablet0.61USD tablet
Mylan-Naproxen Ec 500 mg Enteric-Coated Tablet0.61USD tablet
Novo-Naprox Ec 500 mg Enteric-Coated Tablet0.61USD tablet
Pms-Naproxen Ec 500 mg Enteric-Coated Tablet0.61USD tablet
Naprosyn E 375 mg Enteric-Coated Tablet0.6USD tablet
Naprosyn E 250 mg Enteric-Coated Tablet0.46USD tablet
Apo-Napro-Na 275 mg Tablet0.36USD tablet
Novo-Naprox Sodium 275 mg Tablet0.36USD tablet
Apo-Naproxen Ec 375 mg Enteric-Coated Tablet0.34USD tablet
Mylan-Naproxen Ec 375 mg Enteric-Coated Tablet0.34USD tablet
Novo-Naprox Ec 375 mg Enteric-Coated Tablet0.34USD tablet
Pms-Naproxen Ec 375 mg Enteric-Coated Tablet0.34USD tablet
Apo-Naproxen Ec 250 mg Enteric-Coated Tablet0.26USD tablet
Novo-Naprox Ec 250 mg Enteric-Coated Tablet0.26USD tablet
Apo-Naproxen 500 mg Tablet0.22USD tablet
Novo-Naprox 500 mg Tablet0.22USD tablet
Nu-Naprox 500 mg Tablet0.22USD tablet
Aleve 220 mg gelcap0.19USD capsule
Naprosyn 125 mg/5ml Suspension0.18USD ml
Mediproxen tablet0.17USD tablet
Apo-Naproxen 375 mg Tablet0.15USD tablet
Naproxen sodium 220 mg tablet0.15USD tablet
Novo-Naprox 375 mg Tablet0.15USD tablet
Nu-Naprox 375 mg Tablet0.15USD tablet
CVS Pharmacy all day pain rlf 220 mg tb0.12USD tablet
Wal-proxen 220 mg tablet0.12USD tablet
Apo-Naproxen 250 mg Tablet0.11USD tablet
Novo-Naprox 250 mg Tablet0.11USD tablet
Nu-Naprox 250 mg Tablet0.11USD tablet
All day pain rlf 220 mg caplet0.1USD caplet
Aleve 220 mg caplet0.09USD caplet
Aleve 220 mg tablet0.09USD tablet
Wal-proxen 220 mg caplet0.09USD tablet
Apo-Naproxen 125 mg Tablet0.08USD tablet
All day pain relief 220 mg tablet0.07USD tablet
Naprosyn 25 mg/ml Suspension0.07USD ml
Naproxen sodium 220 mg caplet0.06USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2034096 No2002-03-262011-01-14Canada
US5637320 No1994-06-102014-06-10Us
US5714504 Yes1995-08-032015-08-03Us
US5872145 Yes1998-02-142018-02-14Us
US5900424 Yes1996-11-042016-11-04Us
US6060499 Yes1998-02-142018-02-14Us
US6369085 Yes1998-11-252018-11-25Us
US6586458 Yes1998-02-142018-02-14Us
US6926907 No2003-02-282023-02-28Us
US7332183 Yes2006-04-022026-04-02Us
US7411070 Yes1998-11-252018-11-25Us
US7745466 No1998-10-132018-10-13Us
US8022095 Yes1998-02-142018-02-14Us
US8557285 No2002-05-312022-05-31Us
US8852636 No2002-05-312022-05-31Us
US8858996 No2002-05-312022-05-31Us
US8945621 No2011-10-172031-10-17Us
US9161920 No2002-05-312022-05-31Us
US9198888 No2002-05-312022-05-31Us
US9220698 No2011-03-102031-03-10Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point153 °CPhysProp
water solubility15.9 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP3.18HANSCH,C ET AL. (1995)
logS-4.16ADME Research, USCD
Caco2 permeability-4.83ADME Research, USCD
pKa4.15SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0511 mg/mLALOGPS
logP3.29ALOGPS
logP2.99ChemAxon
logS-3.6ALOGPS
pKa (Strongest Acidic)4.19ChemAxon
pKa (Strongest Basic)-4.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.53 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity64.85 m3·mol-1ChemAxon
Polarizability24.81 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.95 KB)
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-001i-0190000000-64cc22cce1238357760eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-0f79-0900000000-17f4e93fda31d93027a1View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-0fr6-0900000000-4dd08568cff27d62d867View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-000i-0910000000-149b16cac2d80de64d8aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-00di-0900000000-e7dfead967f29853140dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-01b9-0900000000-f5f45cee188a08ef62b1View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-014i-0900000000-6c076658da1c69f1b909View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-014i-0900000000-2e1269f26d5b927bca33View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-000i-0900000000-68cd0c5a3fcc15470c14View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-00di-0900000000-64e5ecb5632e32f89b2dView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
KingdomOrganic compounds
Super ClassBenzenoids
ClassNaphthalenes
Sub ClassNot Available
Direct ParentNaphthalenes
Alternative Parents
Substituents
  • Naphthalene
  • Anisole
  • Alkyl aryl ether
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. James MJ, Cook-Johnson RJ, Cleland LG: Selective COX-2 inhibitors, eicosanoid synthesis and clinical outcomes: a case study of system failure. Lipids. 2007 Sep;42(9):779-85. Epub 2007 Jun 2. [PubMed:17541796 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, p...
Gene Name:
PTGS2
Uniprot ID:
P35354
Molecular Weight:
68995.625 Da
References
  1. Albertini R, Aimbire F, Villaverde AB, Silva JA Jr, Costa MS: COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy. Inflamm Res. 2007 Jun;56(6):228-9. [PubMed:17607546 ]
  2. Dhir A, Naidu PS, Kulkarni SK: Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. Seizure. 2007 Dec;16(8):691-7. Epub 2007 Jul 2. [PubMed:17604186 ]
  3. Kumar P, Padi SS, Naidu PS, Kumar A: Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms. Fundam Clin Pharmacol. 2007 Jun;21(3):297-306. [PubMed:17521299 ]
  4. White WB: Cardiovascular effects of the selective cyclooxygenase-2 inhibitors. Subcell Biochem. 2007;42:145-58. [PubMed:17612049 ]
  5. Hassan-Alin M, Naesdal J, Nilsson-Pieschl C, Langstrom G, Andersson T: Lack of Pharmacokinetic Interaction between Esomeprazole and the Nonsteroidal Anti-Inflammatory Drugs Naproxen and Rofecoxib in Healthy Subjects. Clin Drug Investig. 2005;25(11):731-40. [PubMed:17532719 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Peptostreptococcus magnus
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Binds serum albumin.
Gene Name:
pab
Uniprot ID:
Q51911
Molecular Weight:
43057.45 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular Weight:
59590.91 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol...
Gene Name:
UGT2B7
Uniprot ID:
P16662
Molecular Weight:
60694.12 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Banerjee T, Singh SK, Kishore N: Binding of naproxen and amitriptyline to bovine serum albumin: biophysical aspects. J Phys Chem B. 2006 Nov 30;110(47):24147-56. [PubMed:17125386 ]
  2. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. [PubMed:11883641 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. [PubMed:10991954 ]
  2. Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. [PubMed:10220563 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on December 02, 2016 03:58