Anti-HIV Agents

Name
Anti-HIV Agents
Accession Number
DBCAT000124
Description

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.

Drugs
DrugDrug Description
AldesleukinA recombinant analog of interleukin-2 used to induce an adaptive immune response in the treatment of renal cell carcinoma.
EnfuvirtideAn HIV-1 gp41 fusion inhibitor used in patients experiencing HIV-1 replication who are already being treated with other anti-retrovirals.
NelfinavirA viral protease inhibitor used in the treatment of HIV infection.
IndinavirA protease inhibitor used to treat HIV infection.
NevirapineA non-nucleoside reverse transcriptase inhibitor used as part of a management regimen for HIV-1 virus infection.
Tenofovir disoproxilA nucleotide analog reverse transcriptase inhibitor used in the treatment of Hepatitis B infection and used in the management of HIV-1 infection.
MiglustatA glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement.
ZidovudineA dideoxynucleoside used in the treatment of HIV infection.
RitonavirAn HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection.
StavudineA dideoxynucleoside used in the treatment of HIV infection.
AmprenavirA protease inhibitor used to treat HIV infection.
DelavirdineA non-nucleoside reverse transcriptase inhibitor used to treat HIV infection.
LamivudineA reverse transcriptase inhibitor used to treat HIV and hepatitis B infections.
EmtricitabineA nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
DidanosineA reverse transcriptase inhibitor used to treat HIV.
TipranavirA protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor.
ZalcitabineA dideoxynucleoside used to treat HIV.
AbacavirAn antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV.
AtazanavirAn antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV.
SaquinavirAn HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency.
DarunavirA HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies.
FosamprenavirAn antiretroviral agent used for the treatment and postexposure prophylaxis of human immunodeficiency virus (HIV-1) infection.
LopinavirAn HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection.
UbenimexAn adjuvant therapy used for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia.
MaravirocA CCR5 co-receptor antagonist used with other antiretroviral medications to treat CCR5-tropic HIV-1 infection.
Calanolide AFor use in combination treatment of HIV infection (AIDS).
TroxacitabineInvestigated for use/treatment in leukemia (myeloid).
LeronlimabA humanized monoclonal antibody being investigated
BevirimatInvestigated for use/treatment in HIV infection.
PlerixaforA selective chemokine receptor (CXCR4) antagonist used with filgrastim to mobilize hematopoietic stem cells to the peripheral blood for collection and autologous transplantation in patients with non-Hodgkin’s lymphoma (NHL) and multiple myeloma (MM).
RaltegravirAn antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals.
CapravirineInvestigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections and HIV infection.
RilpivirineA non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1).
DolutegravirAn antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents.
CobicistatA CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection.
CabotegravirCabotegravir has been investigated for the treatment of Acquired Immunodeficiency Syndrome.
CenicrivirocCenicriviroc has been used in trials studying the treatment of HIV-infection/AIDS, AIDS Dementia Complex, Nonalcoholic Steatohepatitis, Human Immunodeficiency Virus, and HIV-1-Associated Cognitive Motor Complex.
AZD-5672Azd5672 has been used in trials studying the basic science and treatment of Pharmacokinetics, Renal Impairment, and Rheumatoid Arthritis.
CensavudineCensavudine has been used in trials studying the treatment of HIV-1 Infection.
LobucavirLobucavir has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections.
TenofovirTenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus. To know more about the specific product indications, please visit the information in the...
Betulinic AcidBetulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome.
PF-232798PF-232798 is under investigation in clinical trial NCT01140425 (Study To Evaluate The Effect Of A Multiple Oral Dose Of PF-00232798 On QT Intervals In Healthy Subjects).
IQP-0528IQP-0528 is under investigation in clinical trial NCT03082690 (ImQuest (IQP) DuoGel Phase 1 Pharmacokinetic Study).
BMS-488043Investigated for use/treatment in HIV infection.
ElvucitabineInvestigated for use/treatment in hepatitis (viral, B) and HIV infection.
DapivirineDapivirine has been investigated for the prevention of HIV-1 Infections and Topical Penile Exposures.
DexelvucitabineDexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus.
IbalizumabA CD4-specific antibody used to treat HIV infections.
BMS-955176BMS-955176 is under investigation in clinical trial NCT02415595 (Dose-finding Study of BMS-955176 to Treat HIV-1 Infected Treatment-naive Adults).
R-82913Not Available
TMC-310911TMC-310911 (also known as ASC-09) is a novel investigational protease inhibitor (PI) that is structurally similar to the currently available darunavir. It is being investigated for use in HIV-1 infections....
Drugs & Drug Targets
DrugTargetType
AldesleukinInterleukin-2 receptor subunit betatarget
AldesleukinInterleukin-2 receptor subunit alphatarget
AldesleukinCytokine receptor common subunit gammatarget
AldesleukinProstaglandin G/H synthase 2enzyme
AldesleukinCytosolic phospholipase A2enzyme
AldesleukinCytochrome P450 3A4enzyme
AldesleukinXanthine dehydrogenase/oxidaseenzyme
AldesleukinCytochrome P450 2E1enzyme
EnfuvirtideEnvelope glycoproteintarget
EnfuvirtideCytochrome P450 2C19enzyme
EnfuvirtideCytochrome P450 2E1enzyme
NelfinavirHIV-1 proteasetarget
NelfinavirCytochrome P450 2C19enzyme
NelfinavirCytochrome P450 3A4enzyme
NelfinavirCytochrome P450 2B6enzyme
NelfinavirCytochrome P450 3A5enzyme
NelfinavirCytochrome P450 3A7enzyme
NelfinavirP-glycoprotein 1transporter
NelfinavirSolute carrier family 22 member 1transporter
NelfinavirSolute carrier organic anion transporter family member 1A2transporter
NelfinavirATP-binding cassette sub-family G member 2transporter
NelfinavirSolute carrier organic anion transporter family member 1B1transporter
NelfinavirCytochrome P450 2D6enzyme
NelfinavirSerum albumincarrier
NelfinavirUDP-glucuronosyltransferase 1-1enzyme
NelfinavirSolute carrier organic anion transporter family member 1B3transporter
NelfinavirSolute carrier organic anion transporter family member 2B1transporter
NelfinavirBile salt export pumptransporter
NelfinavirCytochrome P450 2C9enzyme
IndinavirHuman immunodeficiency virus type 1 proteasetarget
IndinavirCytochrome P450 3A4enzyme
IndinavirCytochrome P450 3A5enzyme
IndinavirCytochrome P450 3A7enzyme
IndinavirP-glycoprotein 1transporter
IndinavirSolute carrier family 22 member 1transporter
IndinavirMultidrug resistance-associated protein 1transporter
IndinavirSolute carrier organic anion transporter family member 1A2transporter
IndinavirSolute carrier organic anion transporter family member 1B1transporter
IndinavirCanalicular multispecific organic anion transporter 1transporter
IndinavirCytochrome P450 2D6enzyme
IndinavirUDP-glucuronosyltransferase 1-1enzyme
IndinavirSolute carrier organic anion transporter family member 2B1transporter
IndinavirBile salt export pumptransporter
NevirapineCytochrome P450 3A4enzyme
NevirapineCytochrome P450 2B6enzyme
NevirapineCytochrome P450 3A5enzyme
NevirapineCytochrome P450 2C9enzyme
NevirapineCytochrome P450 2A6enzyme
NevirapineCytochrome P450 2D6enzyme
NevirapineReverse transcriptase/RNaseHtarget
NevirapineSerum albumincarrier
NevirapineCytochrome P450 1A2enzyme
NevirapineSolute carrier family 22 member 1transporter
NevirapineCytochrome P450 3A7enzyme
Tenofovir disoproxilReverse transcriptase/RNaseHtarget
Tenofovir disoproxilSolute carrier family 22 member 6transporter
Tenofovir disoproxilSolute carrier family 22 member 8transporter
Tenofovir disoproxilMultidrug resistance-associated protein 7transporter
Tenofovir disoproxilMultidrug resistance-associated protein 4transporter
Tenofovir disoproxilCanalicular multispecific organic anion transporter 1transporter
Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
Tenofovir disoproxilP-glycoprotein 1transporter
Tenofovir disoproxilNucleoside diphosphokinaseenzyme
Tenofovir disoproxilCreatine Kinasesenzyme
Tenofovir disoproxilDNA polymerase/reverse transcriptasetarget
MiglustatCeramide glucosyltransferasetarget
ZidovudineSerum albumincarrier
ZidovudineCytochrome P450 2A6enzyme
ZidovudineCytochrome P450 2C9enzyme
ZidovudineCytochrome P450 3A4enzyme
ZidovudineReverse transcriptase/RNaseHtarget
ZidovudineSolute carrier family 22 member 2transporter
ZidovudineSolute carrier family 22 member 6transporter
ZidovudineSolute carrier family 22 member 7transporter
ZidovudineSolute carrier family 22 member 8transporter
ZidovudineSolute carrier family 22 member 11transporter
ZidovudineSodium/nucleoside cotransporter 1transporter
ZidovudineEquilibrative nucleoside transporter 2transporter
ZidovudineP-glycoprotein 1transporter
ZidovudineMultidrug resistance-associated protein 4transporter
ZidovudineMultidrug resistance-associated protein 5transporter
ZidovudineATP-binding cassette sub-family G member 2transporter
ZidovudineTelomerase reverse transcriptasetarget
ZidovudineThymidine kinase, cytosolicenzyme
ZidovudineUDP-glucuronosyltransferase 2B7enzyme
ZidovudineUDP-glucuronosyltransferase 1-1enzyme
RitonavirHuman immunodeficiency virus type 1 proteasetarget
RitonavirCytochrome P450 2D6enzyme
RitonavirCytochrome P450 2C9enzyme
RitonavirCytochrome P450 2C19enzyme
RitonavirCytochrome P450 2B6enzyme
RitonavirCytochrome P450 2C8enzyme
RitonavirP-glycoprotein 1transporter
RitonavirMultidrug resistance-associated protein 1transporter
RitonavirCanalicular multispecific organic anion transporter 1transporter
RitonavirSolute carrier organic anion transporter family member 1A2transporter
RitonavirATP-binding cassette sub-family G member 2transporter
RitonavirSolute carrier organic anion transporter family member 1B1transporter
RitonavirCytochrome P450 1A2enzyme
RitonavirNuclear receptor subfamily 1 group I member 2target
RitonavirSerum albumincarrier
RitonavirCytochrome P450 3A4enzyme
RitonavirCytochrome P450 3A5enzyme
RitonavirCytochrome P450 3A7enzyme
RitonavirUDP-glucuronosyltransferases (UGTs)enzyme
RitonavirSolute carrier organic anion transporter family member 2B1transporter
RitonavirBile salt export pumptransporter
RitonavirAlpha-1-acid glycoprotein 1carrier
RitonavirSolute carrier organic anion transporter family member 1B3transporter
StavudineSolute carrier family 22 member 6transporter
StavudineReverse transcriptase/RNaseHtarget
StavudineSodium/nucleoside cotransporter 1transporter
StavudineSerum albumincarrier
AmprenavirHuman immunodeficiency virus type 1 proteasetarget
AmprenavirCytochrome P450 3A4enzyme
AmprenavirP-glycoprotein 1transporter
AmprenavirMultidrug resistance-associated protein 1transporter
AmprenavirCytochrome P450 2B6enzyme
AmprenavirCytochrome P450 2C19enzyme
AmprenavirCytochrome P450 2C9enzyme
AmprenavirCytochrome P450 2D6enzyme
AmprenavirCytochrome P450 3A5enzyme
AmprenavirSolute carrier organic anion transporter family member 1B1transporter
DelavirdineCytochrome P450 3A4enzyme
DelavirdineCytochrome P450 2C9enzyme
DelavirdineCytochrome P450 2D6enzyme
DelavirdineCytochrome P450 3A5enzyme
DelavirdineCytochrome P450 3A7enzyme
DelavirdineCytochrome P450 2C19enzyme
DelavirdineReverse transcriptase/RNaseHtarget
LamivudineDNAtarget
LamivudineProtein Ptarget
LamivudineMultidrug resistance-associated protein 1transporter
LamivudineSolute carrier family 22 member 6transporter
LamivudineATP-binding cassette sub-family G member 2transporter
LamivudineReverse transcriptase/RNaseHtarget
LamivudineSolute carrier family 22 member 1transporter
LamivudineSolute carrier family 22 member 2transporter
LamivudineSolute carrier family 22 member 3transporter
LamivudineDeoxycytidine kinaseenzyme
LamivudineUMP-CMP kinaseenzyme
LamivudinePhosphoglycerate kinase 1enzyme
LamivudineNucleoside diphosphate kinase Aenzyme
LamivudineNucleoside diphosphate kinase Benzyme
LamivudineCholine-phosphate cytidylyltransferase Aenzyme
LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
LamivudineP-glycoprotein 1transporter
LamivudineMultidrug resistance-associated protein 4transporter
LamivudineCanalicular multispecific organic anion transporter 2transporter
LamivudineCanalicular multispecific organic anion transporter 1transporter
Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
LamivudineSerum albumincarrier
EmtricitabineReverse transcriptase/RNaseHtarget
EmtricitabineDeoxycytidine kinaseenzyme
EmtricitabineSerum albumincarrier
EmtricitabineMultidrug and toxin extrusion protein 1transporter
DidanosineSolute carrier family 22 member 6transporter
DidanosinePurine nucleoside phosphorylasetarget
DidanosineReverse transcriptase/RNaseHtarget
DidanosineEquilibrative nucleoside transporter 1transporter
DidanosineEquilibrative nucleoside transporter 2transporter
DidanosineSerum albumincarrier
TipranavirHuman immunodeficiency virus type 1 proteasetarget
TipranavirCytochrome P450 3A4enzyme
TipranavirCytochrome P450 2D6enzyme
TipranavirCytochrome P450 2C19enzyme
TipranavirBile salt export pumptransporter
TipranavirUDP-glucuronosyltransferase 1-1enzyme
TipranavirSolute carrier organic anion transporter family member 2B1transporter
TipranavirSolute carrier organic anion transporter family member 1B1transporter
TipranavirSolute carrier organic anion transporter family member 1B3transporter
TipranavirP-glycoprotein 1transporter
ZalcitabineDeoxycytidine kinaseenzyme
ZalcitabineSolute carrier family 22 member 6transporter
ZalcitabineSolute carrier family 22 member 7transporter
ZalcitabineReverse transcriptase/RNaseHtarget
ZalcitabineEquilibrative nucleoside transporter 1transporter
ZalcitabineEquilibrative nucleoside transporter 2transporter
ZalcitabineSerum albumincarrier
AbacavirAlcohol dehydrogenase 6enzyme
AbacavirUDP-glucuronosyltransferase 1-1enzyme
AbacavirReverse transcriptase/RNaseHtarget
AbacavirAdenosine kinaseenzyme
AbacavirHLA class I histocompatibility antigen, B-57 alpha chaintarget
AtazanavirHuman immunodeficiency virus type 1 proteasetarget
AtazanavirCytochrome P450 3A4enzyme
AtazanavirCytochrome P450 2C9enzyme
AtazanavirP-glycoprotein 1transporter
AtazanavirMultidrug resistance-associated protein 1transporter
AtazanavirSerum albumincarrier
AtazanavirUDP-glucuronosyltransferase 1-1enzyme
AtazanavirSolute carrier organic anion transporter family member 1B1transporter
AtazanavirSolute carrier organic anion transporter family member 1B3transporter
AtazanavirCytochrome P450 2C8enzyme
AtazanavirBile salt export pumptransporter
Atazanaviralpha1-acid glycoproteincarrier
AtazanavirCytochrome P450 1A2enzyme
AtazanavirSolute carrier organic anion transporter family member 2B1transporter
SaquinavirHuman immunodeficiency virus type 1 proteasetarget
SaquinavirCytochrome P450 3A4enzyme
SaquinavirCytochrome P450 3A5enzyme
SaquinavirAlpha-1-acid glycoprotein 1carrier
SaquinavirSerum albumincarrier
SaquinavirCytochrome P450 3A7enzyme
SaquinavirP-glycoprotein 1transporter
SaquinavirSolute carrier family 22 member 1transporter
SaquinavirSolute carrier organic anion transporter family member 1A2transporter
SaquinavirATP-binding cassette sub-family G member 2transporter
SaquinavirSolute carrier organic anion transporter family member 1B1transporter
SaquinavirMultidrug resistance-associated protein 1transporter
SaquinavirCanalicular multispecific organic anion transporter 1transporter
SaquinavirCytochrome P450 2C8enzyme
SaquinavirCytochrome P450 2D6enzyme
SaquinavirSolute carrier organic anion transporter family member 2B1transporter
SaquinavirBile salt export pumptransporter
DarunavirHuman immunodeficiency virus type 1 proteasetarget
DarunavirCytochrome P450 3A4enzyme
DarunavirSolute carrier organic anion transporter family member 1B1transporter
DarunavirP-glycoprotein 1transporter
DarunavirSerum albumincarrier
DarunavirAlpha-1-acid glycoprotein 1carrier
DarunavirCytochrome P450 2D6enzyme
FosamprenavirHuman immunodeficiency virus type 1 proteasetarget
FosamprenavirCytochrome P450 3A4enzyme
LopinavirHuman immunodeficiency virus type 1 proteasetarget
LopinavirCytochrome P450 3A4enzyme
LopinavirCytochrome P450 2D6enzyme
LopinavirCytochrome P450 2C19enzyme
LopinavirP-glycoprotein 1transporter
LopinavirCytochrome P450 2B6enzyme
LopinavirCytochrome P450 2C9enzyme
LopinavirCytochrome P450 3A Subfamilyenzyme
LopinavirSolute carrier organic anion transporter family member 1B1transporter
LopinavirSolute carrier organic anion transporter family member 1B3transporter
LopinavirBile salt export pumptransporter
LopinavirCytochrome P450 1A2enzyme
LopinavirAlpha-1-acid glycoprotein 1carrier
LopinavirSerum albumincarrier
UbenimexBacterial leucyl aminopeptidasetarget
UbenimexLeukotriene A-4 hydrolasetarget
UbenimexSolute carrier family 15 member 1transporter
UbenimexSolute carrier family 15 member 2transporter
MaravirocC-C chemokine receptor type 5target
MaravirocCytochrome P450 3A4enzyme
Calanolide AGag-Pol polyproteintarget
Calanolide ACytochrome P450 3A4enzyme
TroxacitabineDNAtarget
TroxacitabineDeoxycytidine kinaseenzyme
LeronlimabC-C chemokine receptor type 5target
BevirimatGag-Pol polyproteintarget
PlerixaforC-X-C chemokine receptor type 4target
RaltegravirUDP-glucuronosyltransferase 1-1enzyme
RaltegravirIntegrasetarget
CapravirineCytochrome P450 3A4enzyme
CapravirineGag-Pol polyproteintarget
CapravirineCytochrome P450 2C8enzyme
CapravirineCytochrome P450 2C9enzyme
CapravirineCytochrome P450 2C19enzyme
RilpivirineCytochrome P450 3A4enzyme
RilpivirineReverse transcriptase/RNaseHtarget
RilpivirineNuclear receptor subfamily 1 group I member 2target
RilpivirineCytochrome P450 2C19enzyme
RilpivirineCytochrome P450 2B6enzyme
RilpivirineP-glycoprotein 1transporter
RilpivirineATP-binding cassette sub-family G member 2transporter
RilpivirineSolute carrier organic anion transporter family member 1B1transporter
RilpivirineSolute carrier organic anion transporter family member 1B3transporter
RilpivirineSerum albumincarrier
RilpivirineCytochrome P450 2D6enzyme
DolutegravirUDP-glucuronosyltransferase 1-1enzyme
DolutegravirCytochrome P450 3A Subfamilyenzyme
DolutegravirIntegrasetarget
DolutegravirSolute carrier family 22 member 2transporter
DolutegravirUDP-glucuronosyltransferase 1-3enzyme
DolutegravirUDP-glucuronosyltransferase 1-9enzyme
DolutegravirATP-binding cassette sub-family G member 2transporter
DolutegravirSolute carrier family 22 member 6transporter
DolutegravirSolute carrier family 22 member 8transporter
DolutegravirP-glycoprotein 1transporter
CobicistatCytochrome P450 2D6enzyme
CobicistatP-glycoprotein 1transporter
CobicistatATP-binding cassette sub-family G member 2transporter
CobicistatCytochrome P450 3A4enzyme
CobicistatCytochrome P450 3A5enzyme
CobicistatCytochrome P450 3A7enzyme
CobicistatCytochrome P450 3A43enzyme
CobicistatSolute carrier organic anion transporter family member 1B1transporter
CobicistatSolute carrier organic anion transporter family member 1B3transporter
CabotegravirSolute carrier family 22 member 6transporter
CabotegravirSolute carrier family 22 member 8transporter
TenofovirP-glycoprotein 1transporter
TenofovirSolute carrier family 22 member 6transporter
TenofovirSolute carrier family 22 member 8transporter
TenofovirMultidrug resistance-associated protein 4transporter
TenofovirCytochrome P450 3A4enzyme
TenofovirNucleoside diphosphate kinase Aenzyme
TenofovirNucleoside diphosphate kinase Benzyme
TenofovirAdenylate kinase isoenzyme 1enzyme
TenofovirAdenylate kinase 2, mitochondrialenzyme
TenofovirReverse transcriptase/RNaseHtarget
TenofovirReverse transcriptasetarget
TenofovirDNA polymerasetarget
TenofovirSerum albumincarrier
BMS-488043Free fatty acid receptor 4target
DapivirineGag-Pol polyproteintarget
IbalizumabT-cell surface glycoprotein CD4target
IbalizumabC-C chemokine receptor type 5target
IbalizumabC-X-C chemokine receptor type 4target
R-82913Gag-Pol polyproteintarget
R-82913Gag-Pol polyproteintarget
TMC-310911HIV-1 proteasetarget