Gynecological Antiinfectives and Antiseptics

DrugDrug NameDrug Indication
DB00126Vitamin CUsed to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.
DB00239OxiconazoleFor treatment of dermal fungal infection.
DB00251TerconazoleFor the treatment of candidiasis (a yeast-like fungal infection) of the vulva and vagina.
DB00263SulfisoxazoleFor the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
DB00310ChlorthalidoneFor management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
DB00406Gentian VioletFor the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
DB00436BendroflumethiazideFor the treatment of high blood pressure and management of edema related to heart failure.
DB00524MetolazoneFor the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
DB00562BenzthiazideFor the treatment of high blood pressure and management of edema.
DB00595OxytetracyclineOxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.
DB00614FurazolidoneFor the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.
DB00639ButoconazoleFor the local treatment of vulvovaginal candidiasis (infections caused by Candida)
DB00646NystatinFor treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
DB00664SulfametopyrazineFor the treatment of urinary tract infection and chronic bronchitis.
DB00669SumatriptanFor the treatment of migraine attacks with or without aura.
DB00681Amphotericin BUsed to treat potentially life threatening fungal infections.
DB00774HydroflumethiazideUsed as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
DB00795SulfasalazineFor the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
DB01032ProbenecidFor the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.
DB01119DiazoxideUsed parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.
DB01127EconazoleFor topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
DB01144DiclofenamideFor adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure
DB01152CandicidinUsed in the topical treatment of vulvovaginal candidiasis.
DB01153SertaconazoleFor the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.
DB01264DarunavirDarunavir, co-administered with ritonavir, and with other antiretroviral agents, is indicated for the treatment of human immunodeficiency virus (HIV) infection in antiretroviral treatment-experienced adult patients, such as those with HIV-1 strains resistant to more than one protease inhibitor.
DB01298SulfacytineUsed orally in the treatment of acute urinary tract infections.
DB01299SulfadoxineSulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.
DB01324PolythiazidePolythiazide is a thiazide diuretic used to decrease edema and decrease blood pressure.
DB01582SulfamethazineFor the treatment bacterial infections causing bronchitis, prostatitis and urinary tract infections.
DB03166Acetic acidUsed to treat infections in the ear canal.
DB04209DequaliniumEffective local treatment as vaginal tablets for infections such as fluor vaginalis, bacterial vaginosis, aerobic vaginitis, vulvo-vaginal candidiasis and trichomoniasis. Used as a topical antimicrobial agent.
DB04398Lactic AcidFor use as an alkalinizing agent.
DB05245Silver sulfadiazineIndicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
DB06290SimeprevirIndicated for the treatment of adults with chronic hepatitis C virus (HCV) infection: typically in combination with sofosbuvir in patients with HCV genotype 1 without cirrhosis or with compensated cirrhosis and in combination with peginterferon alfa (Peg-IFN-alfa) and ribavirin (RBV) in patients with HCV genotype 1 or 4 without cirrhosis or with compensated cirrhosis. Resistance: Reduced susceptibility to simeprevir was most commonly associated with the viral NS3 Q80K polymorphism. Amino acid substitutions at NS3 positions S122, R155 and/or D168 are also shown to reduce susceptibility to simeprevir in genotype 1a/b patients.
DB06729SulfaphenazoleFor the treatment bacterial infections.
DB06795MafenideMafenide is indicated in the treatment of severe burns.
DB08796PipazethateFor the treatment of cough.
DB08943IsoconazoleNot Available
DB08958HexetidineNot Available
DB09115DiiodohydroxyquinolineUsed in the treatment of amoebiasis.
DB13492PolicresulenNot Available
DrugDrug NameTargetType
DB00126Vitamin CProlyl 4-hydroxylase subunit alpha-1target
DB00126Vitamin CSolute carrier family 23 member 1target
DB00126Vitamin CProcollagen-lysine,2-oxoglutarate 5-dioxygenase 1target
DB00126Vitamin CHyaluronate lyasetarget
DB00126Vitamin CDNAtarget
DB00126Vitamin CXylose isomerasetarget
DB00126Vitamin CProcollagen-lysine,2-oxoglutarate 5-dioxygenase 2target
DB00126Vitamin CPhytanoyl-CoA dioxygenase, peroxisomaltarget
DB00126Vitamin CProcollagen-lysine,2-oxoglutarate 5-dioxygenase 3target
DB00126Vitamin CGamma-butyrobetaine dioxygenasetarget
DB00126Vitamin CDopamine beta-hydroxylasetarget
DB00126Vitamin CPeptidyl-glycine alpha-amidating monooxygenasetarget
DB00126Vitamin CProlyl 3-hydroxylase 1target
DB00126Vitamin C2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2target
DB00126Vitamin CAlpha-ketoglutarate-dependent dioxygenase alkB homolog 2target
DB00126Vitamin CProlyl 3-hydroxylase 2target
DB00126Vitamin CProlyl 3-hydroxylase 3target
DB00126Vitamin C2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1target
DB00126Vitamin CEgl nine homolog 2target
DB00126Vitamin CAlpha-ketoglutarate-dependent dioxygenase alkB homolog 3target
DB00126Vitamin CLysine-specific demethylase 5Dtarget
DB00126Vitamin CEgl nine homolog 1target
DB00126Vitamin CEgl nine homolog 3target
DB00126Vitamin CTrimethyllysine dioxygenase, mitochondrialtarget
DB00126Vitamin CTransmembrane prolyl 4-hydroxylasetarget
DB00126Vitamin CLactase-phlorizin hydrolasetarget
DB00126Vitamin CSolute carrier family 23 member 1transporter
DB00239OxiconazoleLanosterol 14-alpha demethylasetarget
DB00239OxiconazoleLanosterol synthasetarget
DB00239OxiconazoleCytochrome P450 3A4enzyme
DB00239OxiconazoleCytochrome P450 2C19enzyme
DB00239OxiconazoleNuclear receptor subfamily 1 group I member 2target
DB00251TerconazoleLanosterol 14-alpha demethylasetarget
DB00263SulfisoxazoleDihydropteroate synthasetarget
DB00263SulfisoxazoleCytochrome P450 2C9enzyme
DB00263SulfisoxazoleCytochrome P450 3A4enzyme
DB00310ChlorthalidoneSolute carrier family 12 member 1target
DB00406Gentian VioletDNAtarget
DB00406Gentian VioletSolute carrier family 22 member 1transporter
DB00436BendroflumethiazideSolute carrier family 12 member 3target
DB00436BendroflumethiazideCarbonic anhydrase 1target
DB00436BendroflumethiazideCarbonic anhydrase 2target
DB00436BendroflumethiazideCarbonic anhydrase 4target
DB00436BendroflumethiazideCalcium-activated potassium channel subunit alpha-1target
DB00436BendroflumethiazideThiopurine S-methyltransferaseenzyme
DB00524MetolazoneSolute carrier family 12 member 3target
DB00562BenzthiazideSolute carrier family 12 member 3target
DB00562BenzthiazideCarbonic anhydrase 1target
DB00562BenzthiazideCarbonic anhydrase 2target
DB00562BenzthiazideCarbonic anhydrase 4target
DB00562BenzthiazideCarbonic anhydrase 9target
DB00562BenzthiazideCarbonic anhydrase 12target
DB00595Oxytetracycline30S ribosomal protein S4target
DB00595Oxytetracycline30S ribosomal protein S9target
DB00595Oxytetracycline16S rRNAtarget
DB00595OxytetracyclineSolute carrier family 22 member 6transporter
DB00595OxytetracyclineSolute carrier family 22 member 8transporter
DB00595OxytetracyclineSolute carrier family 22 member 11transporter
DB00595OxytetracyclineSolute carrier family 22 member 7transporter
DB00614FurazolidoneDNAtarget
DB00614FurazolidoneAmine oxidase [flavin-containing] Benzyme
DB00614FurazolidoneAmine oxidase [flavin-containing] Aenzyme
DB00639ButoconazoleErgosteroltarget
DB00646NystatinErgosteroltarget
DB00664SulfametopyrazineDihydropteroate synthetasetarget
DB00669Sumatriptan5-hydroxytryptamine receptor 1Dtarget
DB00669Sumatriptan5-hydroxytryptamine receptor 1Btarget
DB00669Sumatriptan5-hydroxytryptamine receptor 1Ftarget
DB00669SumatriptanAmine oxidase [flavin-containing] Aenzyme
DB00669Sumatriptan5-hydroxytryptamine receptor 1Atarget
DB00669SumatriptanSolute carrier organic anion transporter family member 1A2transporter
DB00669SumatriptanMultidrug resistance protein 1transporter
DB00669SumatriptanATP-binding cassette sub-family G member 2transporter
DB00669SumatriptanSolute carrier organic anion transporter family member 1B1transporter
DB00681Amphotericin BErgosteroltarget
DB00774HydroflumethiazideSolute carrier family 12 member 1target
DB00774HydroflumethiazideSodium/potassium-transporting ATPase subunit alpha-1target
DB00774HydroflumethiazideCarbonic anhydrase 4target
DB00774HydroflumethiazideCalcium-activated potassium channel subunit alpha-1target
DB00774HydroflumethiazideCarbonic anhydrase 2target
DB00774HydroflumethiazideCarbonic anhydrase 1target
DB00774HydroflumethiazideCarbonic anhydrase 9target
DB00774HydroflumethiazideCarbonic anhydrase 12target
DB00795SulfasalazineAcetyl-CoA acetyltransferase, mitochondrialtarget
DB00795SulfasalazineCystine/glutamate transportertarget
DB00795SulfasalazineATP-binding cassette sub-family G member 2transporter
DB00795SulfasalazineCanalicular multispecific organic anion transporter 1transporter
DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00795SulfasalazineProstaglandin G/H synthase 2target
DB00795SulfasalazinePeroxisome proliferator-activated receptor gammatarget
DB00795SulfasalazineProstaglandin G/H synthase 1target
DB00795SulfasalazineArachidonate 5-lipoxygenasetarget
DB00795SulfasalazineCytochrome P450 3A5enzyme
DB00795SulfasalazineProton-coupled folate transportertransporter
DB00795SulfasalazineThromboxane-A synthasetarget
DB00795SulfasalazinePhospholipase A2target
DB01032ProbenecidSolute carrier family 22 member 8target
DB01032ProbenecidSolute carrier family 22 member 11target
DB01032ProbenecidSerum albumincarrier
DB01032ProbenecidCytochrome P450 2C9enzyme
DB01032ProbenecidCytochrome P450 2C19enzyme
DB01032ProbenecidSolute carrier family 22 member 2transporter
DB01032ProbenecidSolute carrier family 22 member 1transporter
DB01032ProbenecidCanalicular multispecific organic anion transporter 2transporter
DB01032ProbenecidMultidrug resistance-associated protein 4transporter
DB01032ProbenecidMultidrug resistance-associated protein 5transporter
DB01032ProbenecidMonocarboxylate transporter 2transporter
DB01032ProbenecidSolute carrier family 22 member 5transporter
DB01032ProbenecidMultidrug resistance-associated protein 6transporter
DB01032ProbenecidMultidrug resistance protein 1transporter
DB01032ProbenecidMultidrug resistance-associated protein 1transporter
DB01032ProbenecidSolute carrier organic anion transporter family member 1A2transporter
DB01032ProbenecidMonocarboxylate transporter 1transporter
DB01032ProbenecidSodium/bile acid cotransportertransporter
DB01032ProbenecidSolute carrier family 22 member 6transporter
DB01032ProbenecidSolute carrier family 22 member 10transporter
DB01032ProbenecidSolute carrier family 22 member 8transporter
DB01032ProbenecidCanalicular multispecific organic anion transporter 1transporter
DB01032ProbenecidATP-binding cassette sub-family C member 11transporter
DB01032ProbenecidSolute carrier family 22 member 11transporter
DB01032ProbenecidSolute carrier organic anion transporter family member 1C1transporter
DB01032ProbenecidSolute carrier family 22 member 7transporter
DB01032ProbenecidSolute carrier family 22 member 6target
DB01032ProbenecidPannexin-1target
DB01032ProbenecidCytochrome P450 2C8enzyme
DB01032ProbenecidCytochrome P450 3A4enzyme
DB01032ProbenecidSolute carrier family 22 member 12transporter
DB01032ProbenecidSolute carrier family 2, facilitated glucose transporter member 9transporter
DB01032ProbenecidTaste receptor type 2 member 16target
DB01119DiazoxideSolute carrier family 12 member 3target
DB01119DiazoxideCarbonic anhydrase 1target
DB01119DiazoxideCarbonic anhydrase 2target
DB01119DiazoxideCalcium-activated potassium channel subunit alpha-1target
DB01119DiazoxideSodium/potassium-transporting ATPase subunit alpha-1target
DB01119DiazoxideATP-sensitive inward rectifier potassium channel 11target
DB01119DiazoxideGlutamine synthetaseenzyme
DB01127EconazoleCytochrome P450 19A1enzyme
DB01127EconazoleCytochrome P450 2E1enzyme
DB01127EconazoleCytochrome P450 3A4enzyme
DB01127EconazoleLanosterol 14-alpha demethylasetarget
DB01127EconazoleNuclear receptor subfamily 1 group I member 2target
DB01144DiclofenamideCarbonic anhydrase 1target
DB01144DiclofenamideCytochrome P450 2C9enzyme
DB01144DiclofenamideCarbonic anhydrase 4target
DB01144DiclofenamideCarbonic anhydrase 2target
DB01144DiclofenamideCarbonic anhydrase 7target
DB01144DiclofenamideCarbonic anhydrase 3target
DB01152CandicidinErgosteroltarget
DB01153SertaconazoleLanosterol 14-alpha demethylaseenzyme
DB01153SertaconazoleLanosterol 14-alpha demethylasetarget
DB01264DarunavirHuman immunodeficiency virus type 1 proteasetarget
DB01264DarunavirCytochrome P450 3A4enzyme
DB01298SulfacytineDihydropteroate synthasetarget
DB01299SulfadoxineDihydropteroate synthetasetarget
DB01299SulfadoxineBifunctional dihydrofolate reductase-thymidylate synthasetarget
DB01324PolythiazideSolute carrier family 12 member 3target
DB01582SulfamethazineDihydropteroate synthasetarget
DB01582SulfamethazineSerum albumincarrier
DB01582SulfamethazineArylamine N-acetyltransferaseenzyme
DB03166Acetic acidSolute carrier organic anion transporter family member 2B1transporter
DB03166Acetic acidMonocarboxylate transporter 1transporter
DB04209DequaliniumHTH-type transcriptional regulator QacRtarget
DB04209DequaliniumAcriflavine resistance protein Btarget
DB04209DequaliniumE3 ubiquitin-protein ligase XIAPtarget
DB04209DequaliniumcGMP-gated cation channel alpha-1target
DB04209DequaliniumCalcium-activated potassium channel subunit alpha-1target
DB04398Lactic AcidBifunctional protein PutAtarget
DB04398Lactic AcidNimA-related proteintarget
DB04398Lactic AcidMonocarboxylate transporter 2transporter
DB04398Lactic AcidSolute carrier organic anion transporter family member 2B1transporter
DB04398Lactic AcidMonocarboxylate transporter 1transporter
DB04398Lactic AcidMonocarboxylate transporter 10transporter
DB04398Lactic AcidSolute carrier organic anion transporter family member 2A1transporter
DB04398Lactic AcidMonocarboxylate transporter 4transporter
DB05245Silver sulfadiazineDNAtarget
DB06290SimeprevirNS3 proteasetarget
DB06290SimeprevirSerum albumincarrier
DB06290SimeprevirCytochrome P450 1A2enzyme
DB06290SimeprevirMultidrug resistance protein 1transporter
DB06290SimeprevirSolute carrier organic anion transporter family member 1B1transporter
DB06290SimeprevirSolute carrier organic anion transporter family member 1B3transporter
DB06290SimeprevirCYP3Aenzyme
DB06290SimeprevirCytochrome P450 3A4enzyme
DB06290SimeprevirCanalicular multispecific organic anion transporter 1transporter
DB06290SimeprevirATP-binding cassette sub-family G member 2transporter
DB06290SimeprevirSolute carrier organic anion transporter family member 2B1transporter
DB06290SimeprevirSodium/bile acid cotransportertransporter
DB06290SimeprevirBile salt export pumptransporter
DB06729SulfaphenazoleCytochrome P450 2C9enzyme
DB06729SulfaphenazoleCytochrome P450 2A6enzyme
DB06729SulfaphenazoleCytochrome P450 2B6enzyme
DB06729SulfaphenazoleCytochrome P450 2C8enzyme
DB06729SulfaphenazoleCytochrome P450 2D6enzyme
DB06729SulfaphenazoleDihydropteroate synthasetarget
DB06795MafenideCarbonic anhydrase 6target