Post-Operative Pain

Also known as: Pain, Post-operative / Procedural pain / Postoperative pain / Postoperative pain NOS / Pain, Postoperative

DrugDrug NameDrug Description
DB01563Chloral hydrateA hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.
DB00996GabapentinGabapentin (brand name Neurontin) is a medication originally developed for the treatment of epilepsy. Presently, gabapentin is widely used to relieve pain, especially neuropathic pain. Gabapentin is well tolerated in most patients, has a relatively mild side-effect profile, and passes through the body unmetabolized.
DB08439ParecoxibParecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. In 2005, the U.S. Food and Drug Administration (FDA) issued a letter of non-approval for parecoxib in the United States.
DrugDrug NamePhaseStatusCount
DB00230Pregabalin0Completed1
DB00633Dexmedetomidine1 / 2Completed1
DB00083Botulinum toxin type A2Recruiting1
DB00297Bupivacaine2Recruiting1
DB00633Dexmedetomidine2Completed1
DB00633Dexmedetomidine2Terminated1
DB00829Diazepam2Recruiting1
DB00668Epinephrine2Recruiting1
DB01050Ibuprofen2Completed1
DB01009Ketoprofen2Unknown Status1
DB00814Meloxicam2Completed1
DB01017Minocycline2Completed1
DB00295Morphine2Completed2
DB05354Morphine2Completed1
DB00295Morphine2Recruiting1
DB08439Parecoxib2Completed1
DB09145Water2Completed1
DB09145Water2Recruiting1
DB00316Acetaminophen3Completed1
DB00318Codeine3Completed1
DB01234Dexamethasone3Unknown Status1
DB00996Gabapentin3Completed1
DB01050Ibuprofen3Completed2
DB01221Ketamine3Unknown Status1
DB00465Ketorolac3Not Yet Recruiting1
DB00814Meloxicam3Completed3
DB01192Oxymorphone3Completed1
DB01192Oxymorphone3Recruiting1
DB00230Pregabalin3Completed1
DB00296Ropivacaine3Not Yet Recruiting1
DB00708Sufentanil3Completed3
DB00316Acetaminophen4Completed1
DB00316Acetaminophen4Unknown Status1
DB00297Bupivacaine4Completed3
DB00297Bupivacaine4Enrolling by Invitation1
DB00297Bupivacaine4Not Yet Recruiting1
DB00575Clonidine4Completed1
DB00668Epinephrine4Completed1
DB01628Etoricoxib4Terminated1
DB00813Fentanyl4Completed1
DB00328Indometacin4Completed1
DB01221Ketamine4Active Not Recruiting1
DB00281Lidocaine4Completed1
DB01043Memantine4Unknown Status1
DB00295Morphine4Completed2
DB00295Morphine4Recruiting1
DB08439Parecoxib4Completed1
DB00230Pregabalin4Completed1
DB00296Ropivacaine4Completed1
DB09153Sodium Chloride4Not Yet Recruiting1
DB00316AcetaminophenNot AvailableCompleted1
DB00316AcetaminophenNot AvailableEnrolling by Invitation1
DB00297BupivacaineNot AvailableActive Not Recruiting1
DB00297BupivacaineNot AvailableTerminated1
DB11121ChloroxylenolNot AvailableRecruiting1
DB00668EpinephrineNot AvailableActive Not Recruiting1
DB01002LevobupivacaineNot AvailableCompleted1
DB00281LidocaineNot AvailableActive Not Recruiting1
DB00333MethadoneNot AvailableRecruiting1
DB00296RopivacaineNot AvailableCompleted2
DB09153Sodium ChlorideNot AvailableNot Yet Recruiting1