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Identification
NameHirulog
Accession NumberDB02351  (EXPT03302)
TypeSmall Molecule
GroupsExperimental
DescriptionNot Available
Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIINot Available
CAS number128270-60-0
WeightAverage: 2180.2853
Monoisotopic: 2178.985813062
Chemical FormulaC98H138N24O33
InChI KeyOIRCOABEOLEUMC-GEJPAHFPSA-N
InChI
InChI=1S/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65(44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93(150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1
IUPAC Name
(4S)-4-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-(2-{2-[2-(2-{[(2S)-1-[(2S)-2-{[(2S)-1-[(2R)-2-amino-3-phenylpropanoyl]pyrrolidin-2-yl]formamido}-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]formamido}acetamido)acetamido]acetamido}acetamido)-3-carbamoylpropanamido]acetamido}-3-carboxypropanamido]-3-phenylpropanamido]-4-carboxybutanamido]-4-{[(2S,3S)-1-[(2S)-2-{[(1S)-3-carboxy-1-{[(1S)-3-carboxy-1-{[(1S)-1-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}propyl]carbamoyl}propyl]carbamoyl}pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]carbamoyl}butanoic acid
SMILES
CC[[email protected]](C)[[email protected]](NC(=O)[[email protected]](CCC(O)=O)NC(=O)[[email protected]](CCC(O)=O)NC(=O)[[email protected]](CC1=CC=CC=C1)NC(=O)[[email protected]](CC(O)=O)NC(=O)CNC(=O)[[email protected]](CC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[[email protected]](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[[email protected]](N)CC1=CC=CC=C1)C(=O)N1CCC[[email protected]]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(O)=O
Pharmacology
IndicationNot Available
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
ProthrombinProteinunknown
inhibitor
HumanP00734 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Hirulog.Approved, Investigational
AbciximabAbciximab may increase the anticoagulant activities of Hirulog.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Hirulog.Approved
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Hirulog.Approved
AcetovanilloneAcetovanillone may increase the anticoagulant activities of Hirulog.Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Hirulog.Approved
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Hirulog.Approved, Investigational
AllylestrenolThe therapeutic efficacy of Hirulog can be decreased when used in combination with Allylestrenol.Approved
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Hirulog.Approved, Illicit, Investigational
AlprostadilAlprostadil may increase the anticoagulant activities of Hirulog.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Hirulog.Approved
AltrenogestThe therapeutic efficacy of Hirulog can be decreased when used in combination with Altrenogest.Vet Approved
ALX-0081ALX-0081 may increase the anticoagulant activities of Hirulog.Investigational
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Hirulog.Experimental
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Hirulog.Illicit, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Hirulog.Approved
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Hirulog.Approved
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Hirulog.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Hirulog.Approved
AncrodHirulog may increase the anticoagulant activities of Ancrod.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Hirulog.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Hirulog.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Hirulog.Approved
Antithrombin III humanHirulog may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanApixaban may increase the anticoagulant activities of Hirulog.Approved
ApremilastApremilast may increase the anticoagulant activities of Hirulog.Approved, Investigational
ArdeparinArdeparin may increase the anticoagulant activities of Hirulog.Approved, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Hirulog.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Hirulog.Investigational
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Hirulog.Approved
AzapropazoneAzapropazone may increase the anticoagulant activities of Hirulog.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Hirulog.Approved
BalsalazideBalsalazide may increase the anticoagulant activities of Hirulog.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Hirulog.Experimental
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Hirulog.Approved, Investigational
BecaplerminBecaplermin may increase the anticoagulant activities of Hirulog.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Hirulog.Approved
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Hirulog.Withdrawn
BeraprostBeraprost may increase the anticoagulant activities of Hirulog.Investigational
Betulinic AcidBetulinic Acid may increase the anticoagulant activities of Hirulog.Investigational
BivalirudinBivalirudin may increase the anticoagulant activities of Hirulog.Approved, Investigational
BoceprevirThe serum concentration of Hirulog can be decreased when it is combined with Boceprevir.Approved
BromfenacBromfenac may increase the anticoagulant activities of Hirulog.Approved
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Hirulog.Approved, Investigational
BucillamineBucillamine may increase the anticoagulant activities of Hirulog.Investigational
ButylphthalideButylphthalide may increase the anticoagulant activities of Hirulog.Investigational
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Hirulog.Approved
CangrelorCangrelor may increase the anticoagulant activities of Hirulog.Approved
CarbamazepineThe metabolism of Hirulog can be increased when combined with Carbamazepine.Approved, Investigational
CarprofenCarprofen may increase the anticoagulant activities of Hirulog.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Hirulog.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Hirulog.Approved, Investigational
CertoparinHirulog may increase the anticoagulant activities of Certoparin.Approved
ChloroquineChloroquine may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Hirulog.Withdrawn
CilostazolCilostazol may increase the anticoagulant activities of Hirulog.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Hirulog.Approved, Investigational, Withdrawn
Citric AcidHirulog may increase the anticoagulant activities of Citric Acid.Nutraceutical, Vet Approved
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Hirulog.Approved
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Hirulog.Approved, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Hirulog.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Hirulog.Approved, Nutraceutical
CollagenaseThe risk or severity of adverse effects can be increased when Hirulog is combined with Collagenase.Approved
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Hirulog.Approved
CurcuminCurcumin may increase the anticoagulant activities of Hirulog.Investigational
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Hirulog.Approved
CyclophosphamideThe risk or severity of adverse effects can be increased when Hirulog is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Hirulog.Approved, Investigational, Vet Approved
D-LimoneneD-Limonene may increase the anticoagulant activities of Hirulog.Investigational
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Hirulog.Approved
DalteparinHirulog may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidHirulog may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DasatinibDasatinib may increase the anticoagulant activities of Hirulog.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Hirulog is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Hirulog.Approved, Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Hirulog.Approved
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Hirulog is combined with Deoxycholic Acid.Approved
dersalazinedersalazine may increase the anticoagulant activities of Hirulog.Investigational
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Hirulog.Approved
DesirudinHirulog may increase the anticoagulant activities of Desirudin.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Hirulog.Investigational
DesogestrelThe therapeutic efficacy of Hirulog can be decreased when used in combination with Desogestrel.Approved
DextranHirulog may increase the anticoagulant activities of Dextran.Approved, Vet Approved
Dextran 40Hirulog may increase the anticoagulant activities of Dextran 40.Approved
Dextran 70Hirulog may increase the anticoagulant activities of Dextran 70.Approved
Dextran 75Hirulog may increase the anticoagulant activities of Dextran 75.Approved
DiclofenacDiclofenac may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Hirulog.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Hirulog.Approved
DienogestThe therapeutic efficacy of Hirulog can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Hirulog.Approved
DiflunisalDiflunisal may increase the anticoagulant activities of Hirulog.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Hirulog.Approved
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Hirulog.Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Hirulog.Approved
DipyridamoleDipyridamole may increase the anticoagulant activities of Hirulog.Approved
DitazoleDitazole may increase the anticoagulant activities of Hirulog.Approved, Withdrawn
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Hirulog.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Hirulog.Approved
DrospirenoneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Drospirenone.Approved
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Hirulog.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Hirulog.Approved
DuvelisibDuvelisib may increase the anticoagulant activities of Hirulog.Investigational
DydrogesteroneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Dydrogesterone.Approved, Withdrawn
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Hirulog.Approved
E6201E6201 may increase the anticoagulant activities of Hirulog.Investigational
EbselenEbselen may increase the anticoagulant activities of Hirulog.Investigational
Edetic AcidEdetic Acid may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Hirulog.Approved
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Hirulog.Approved, Investigational
EnoxaparinEnoxaparin may increase the anticoagulant activities of Hirulog.Approved
EpinastineEpinastine may increase the anticoagulant activities of Hirulog.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Hirulog.Approved
eplivanserineeplivanserine may increase the anticoagulant activities of Hirulog.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Hirulog.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Hirulog.Approved, Investigational
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Hirulog.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Hirulog.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Hirulog.Approved
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Hirulog.Investigational
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Hirulog.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Hirulog.Approved
EstriolEstriol may decrease the anticoagulant activities of Hirulog.Approved, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Hirulog.Approved
EstroneEstrone may decrease the anticoagulant activities of Hirulog.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Hirulog.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Hirulog.Approved, Investigational
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Hirulog.Approved
Ethyl biscoumacetateHirulog may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Ethynodiol diacetateThe therapeutic efficacy of Hirulog can be decreased when used in combination with Ethynodiol diacetate.Approved
EtodolacEtodolac may increase the anticoagulant activities of Hirulog.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Hirulog.Approved
EtonogestrelThe therapeutic efficacy of Hirulog can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Hirulog.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Hirulog.Approved
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Hirulog.Approved
exisulindexisulind may increase the anticoagulant activities of Hirulog.Investigational
FenbufenFenbufen may increase the anticoagulant activities of Hirulog.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Hirulog.Approved
FibrinolysinFibrinolysin may increase the anticoagulant activities of Hirulog.Approved
FloctafenineFloctafenine may increase the anticoagulant activities of Hirulog.Approved, Withdrawn
FluindioneHirulog may increase the anticoagulant activities of Fluindione.Investigational
FlunixinFlunixin may increase the anticoagulant activities of Hirulog.Vet Approved
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Hirulog.Approved, Investigational
FondaparinuxHirulog may increase the anticoagulant activities of Fondaparinux.Investigational
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Hirulog.Approved, Investigational
GabexateHirulog may increase the anticoagulant activities of Gabexate.Investigational
GarlicThe serum concentration of Hirulog can be decreased when it is combined with Garlic.Approved
GenisteinGenistein may decrease the anticoagulant activities of Hirulog.Investigational
GestodeneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Gestodene.Approved
GestrinoneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Gestrinone.Approved
HeminHemin may increase the anticoagulant activities of Hirulog.Approved
HeparinHeparin may increase the anticoagulant activities of Hirulog.Approved, Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Hirulog.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Hirulog.Investigational
HMPL-004HMPL-004 may increase the anticoagulant activities of Hirulog.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Hirulog can be decreased when used in combination with Hydroxyprogesterone caproate.Approved
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Hirulog is combined with Ibritumomab tiuxetan.Approved
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Hirulog.Approved
IbudilastIbudilast may increase the anticoagulant activities of Hirulog.Approved, Investigational
IbuprofenIbuprofen may increase the anticoagulant activities of Hirulog.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Hirulog.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Hirulog.Approved
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Hirulog.Approved, Nutraceutical
idraparinuxHirulog may increase the anticoagulant activities of idraparinux.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Hirulog.Approved, Withdrawn
IloprostIloprost may increase the anticoagulant activities of Hirulog.Approved, Investigational
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Hirulog.Approved
IndobufenIndobufen may increase the anticoagulant activities of Hirulog.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Hirulog.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Hirulog.Withdrawn
IsoxicamIsoxicam may increase the anticoagulant activities of Hirulog.Withdrawn
Kct 0809Kct 0809 may increase the anticoagulant activities of Hirulog.Investigational
KebuzoneKebuzone may increase the anticoagulant activities of Hirulog.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Hirulog.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Hirulog.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Hirulog.Approved, Investigational
LepirudinLepirudin may increase the anticoagulant activities of Hirulog.Approved
LevonorgestrelThe therapeutic efficacy of Hirulog can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Hirulog.Approved
LisofyllineLisofylline may increase the anticoagulant activities of Hirulog.Investigational
LornoxicamLornoxicam may increase the anticoagulant activities of Hirulog.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Hirulog.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Hirulog.Approved
LumiracoxibLumiracoxib may increase the anticoagulant activities of Hirulog.Approved, Investigational
LynestrenolThe therapeutic efficacy of Hirulog can be decreased when used in combination with Lynestrenol.Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Hirulog.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Hirulog.Approved
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Hirulog can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Hirulog.Approved
Megestrol acetateThe therapeutic efficacy of Hirulog can be decreased when used in combination with Megestrol acetate.Approved, Vet Approved
MeloxicamMeloxicam may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Hirulog.Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Hirulog.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Hirulog.Withdrawn
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Hirulog.Experimental
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Hirulog.Approved, Illicit
MilrinoneMilrinone may increase the anticoagulant activities of Hirulog.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Hirulog.Approved
MizoribineMizoribine may increase the anticoagulant activities of Hirulog.Investigational
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Hirulog.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Hirulog.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Hirulog.Approved
NadroparinHirulog may increase the anticoagulant activities of Nadroparin.Approved
NafamostatNafamostat may increase the anticoagulant activities of Hirulog.Investigational
NaftifineNaftifine may increase the anticoagulant activities of Hirulog.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Hirulog.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
NCX 4016NCX 4016 may increase the anticoagulant activities of Hirulog.Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Hirulog.Approved, Withdrawn
NepafenacNepafenac may increase the anticoagulant activities of Hirulog.Approved
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Hirulog.Approved
NimesulideNimesulide may increase the anticoagulant activities of Hirulog.Approved, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Hirulog is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Hirulog.Investigational
NomegestrolThe therapeutic efficacy of Hirulog can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Norethisterone.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Hirulog.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Hirulog is combined with Obinutuzumab.Approved
OlopatadineOlopatadine may increase the anticoagulant activities of Hirulog.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Hirulog.Approved
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Hirulog is combined with Omacetaxine mepesuccinate.Approved
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Hirulog.Approved
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Hirulog.Investigational
OrgoteinOrgotein may increase the anticoagulant activities of Hirulog.Vet Approved
OtamixabanHirulog may increase the anticoagulant activities of Otamixaban.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Hirulog.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Hirulog.Withdrawn
ParecoxibParecoxib may increase the anticoagulant activities of Hirulog.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Hirulog.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Hirulog.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Hirulog.Approved, Investigational
PethidineThe risk or severity of adverse effects can be increased when Hirulog is combined with Pethidine.Approved
PhenindionePhenindione may increase the anticoagulant activities of Hirulog.Approved
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Hirulog.Approved
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
PimecrolimusPimecrolimus may increase the anticoagulant activities of Hirulog.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Hirulog.Approved
PirfenidonePirfenidone may increase the anticoagulant activities of Hirulog.Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Hirulog.Approved, Investigational
PlasminPlasmin may increase the anticoagulant activities of Hirulog.Investigational
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Hirulog.Approved
PrasugrelPrasugrel may increase the anticoagulant activities of Hirulog.Approved
ProgesteroneThe therapeutic efficacy of Hirulog can be decreased when used in combination with Progesterone.Approved, Vet Approved
PromestrienePromestriene may decrease the anticoagulant activities of Hirulog.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Hirulog.Approved
Protein CHirulog may increase the anticoagulant activities of Protein C.Approved
Protein S humanHirulog may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeHirulog may increase the anticoagulant activities of Protocatechualdehyde.Approved
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Hirulog.Approved
PTC299PTC299 may increase the anticoagulant activities of Hirulog.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Hirulog.Approved
RamatrobanRamatroban may increase the anticoagulant activities of Hirulog.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Hirulog.Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Hirulog.Approved
ReviparinHirulog may increase the anticoagulant activities of Reviparin.Approved
RidogrelRidogrel may increase the anticoagulant activities of Hirulog.Approved
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Hirulog.Approved
RivaroxabanHirulog may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Hirulog.Investigational, Withdrawn
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Hirulog.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Hirulog.Approved
S EquolS Equol may decrease the anticoagulant activities of Hirulog.Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Hirulog.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Hirulog.Approved
SCH-530348SCH-530348 may increase the anticoagulant activities of Hirulog.Investigational
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Hirulog.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Hirulog.Approved
SeratrodastSeratrodast may increase the anticoagulant activities of Hirulog.Approved, Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Hirulog.Approved, Vet Approved
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Hirulog.Approved, Investigational
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Hirulog.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Hirulog.Approved
SRT501SRT501 may increase the anticoagulant activities of Hirulog.Investigational
St. John's WortThe metabolism of Hirulog can be increased when combined with St. John's Wort.Nutraceutical
StreptokinaseStreptokinase may increase the anticoagulant activities of Hirulog.Approved
SugammadexSugammadex may increase the anticoagulant activities of Hirulog.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Hirulog.Approved
SulindacSulindac may increase the anticoagulant activities of Hirulog.Approved
SulodexideHirulog may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Hirulog.Approved, Withdrawn
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Hirulog.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Hirulog.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Hirulog.Approved, Investigational
TemsirolimusThe risk or severity of adverse effects can be increased when Hirulog is combined with Temsirolimus.Approved
TenecteplaseTenecteplase may increase the anticoagulant activities of Hirulog.Approved
TenoxicamTenoxicam may increase the anticoagulant activities of Hirulog.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Hirulog.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Hirulog.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Hirulog.Investigational
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Hirulog.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Hirulog.Approved
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Hirulog.Approved
TiboloneTibolone may increase the anticoagulant activities of Hirulog.Approved
TicagrelorTicagrelor may increase the anticoagulant activities of Hirulog.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Hirulog.Approved
TinoridineTinoridine may increase the anticoagulant activities of Hirulog.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Hirulog.Approved
TipranavirThe serum concentration of Hirulog can be decreased when it is combined with Tipranavir.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Hirulog.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Hirulog.Approved
TolmetinTolmetin may increase the anticoagulant activities of Hirulog.Approved
TositumomabThe risk or severity of adverse effects can be increased when Hirulog is combined with Tositumomab.Approved
TranilastTranilast may increase the anticoagulant activities of Hirulog.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Hirulog.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Hirulog.Approved, Investigational
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Hirulog.Approved
TriflusalTriflusal may increase the anticoagulant activities of Hirulog.Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Hirulog.Approved
Trisalicylate-cholineTrisalicylate-choline may increase the anticoagulant activities of Hirulog.Approved
UrokinaseUrokinase may increase the anticoagulant activities of Hirulog.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Hirulog.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Hirulog.Approved, Investigational
VerapamilThe metabolism of Verapamil can be decreased when combined with Hirulog.Approved
Vitamin EVitamin E may increase the anticoagulant activities of Hirulog.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Hirulog.Approved
WarfarinWarfarin may increase the anticoagulant activities of Hirulog.Approved
XimelagatranHirulog may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
Ym150Hirulog may increase the anticoagulant activities of Ym150.Investigational
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Hirulog.Approved
ZeranolZeranol may decrease the anticoagulant activities of Hirulog.Vet Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Hirulog.Approved
ZileutonZileuton may increase the anticoagulant activities of Hirulog.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Hirulog.Withdrawn
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8811
Blood Brain Barrier-0.996
Caco-2 permeable-0.8319
P-glycoprotein substrateSubstrate0.8692
P-glycoprotein inhibitor INon-inhibitor0.647
P-glycoprotein inhibitor IINon-inhibitor0.7858
Renal organic cation transporterNon-inhibitor0.7959
CYP450 2C9 substrateNon-substrate0.7558
CYP450 2D6 substrateNon-substrate0.7957
CYP450 3A4 substrateSubstrate0.5794
CYP450 1A2 substrateNon-inhibitor0.8977
CYP450 2C9 inhibitorNon-inhibitor0.8331
CYP450 2D6 inhibitorNon-inhibitor0.8894
CYP450 2C19 inhibitorNon-inhibitor0.7784
CYP450 3A4 inhibitorNon-inhibitor0.744
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9357
Ames testNon AMES toxic0.7642
CarcinogenicityNon-carcinogens0.8217
BiodegradationNot ready biodegradable0.9705
Rat acute toxicity3.1654 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9307
hERG inhibition (predictor II)Non-inhibitor0.514
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0464 mg/mLALOGPS
logP-0.76ALOGPS
logP-14ChemAxon
logS-4.7ALOGPS
pKa (Strongest Acidic)2.79ChemAxon
pKa (Strongest Basic)11.88ChemAxon
Physiological Charge-4ChemAxon
Hydrogen Acceptor Count37ChemAxon
Hydrogen Donor Count28ChemAxon
Polar Surface Area901.57 Å2ChemAxon
Rotatable Bond Count66ChemAxon
Refractivity543.33 m3·mol-1ChemAxon
Polarizability215.46 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
KingdomOrganic compounds
Super ClassOrganic Polymers
ClassPolypeptides
Sub ClassNot Available
Direct ParentPolypeptides
Alternative Parents
Substituents
  • Polypeptide
  • Alpha peptide
  • Hexacarboxylic acid or derivatives
  • N-acyl-aliphatic-alpha amino acid
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • Alpha-amino acid amide
  • N-acyl-l-alpha-amino acid
  • Phenylpropylamine
  • Amphetamine or derivatives
  • Alpha-amino acid or derivatives
  • N-substituted-alpha-amino acid
  • Pyrrolidine-2-carboxamide
  • Pyrrolidine carboxylic acid or derivatives
  • N-acylpyrrolidine
  • Aralkylamine
  • Phenol
  • Amino fatty acid
  • Fatty acyl
  • Benzenoid
  • N-acyl-amine
  • Fatty amide
  • Monocyclic benzene moiety
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Primary carboxylic acid amide
  • Guanidine
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboximidamide
  • Carboxylic acid
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Imine
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Thrombospondin receptor activity
Specific Function:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Gene Name:
F2
Uniprot ID:
P00734
Molecular Weight:
70036.295 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23