Clinafloxacin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Clinafloxacin
Accession Number
DB14025
Type
Small Molecule
Groups
Investigational
Description

Clinafloxacin is an investigational fluoroquinolone antibiotic. Despite its promising antibiotic activity, the clinical development of clinafloxacin has been hampered by its risk for inducing serious side effects.

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Clinafloxacin hydrochlorideG17M59V0FY105956-99-8BMACYHMTJHBPOX-UHFFFAOYSA-N
Categories
UNII
8N86XTF9QD
CAS number
105956-97-6
Weight
Average: 365.79
Monoisotopic: 365.0942473
Chemical Formula
C17H17ClFN3O3
InChI Key
QGPKADBNRMWEQR-UHFFFAOYSA-N
InChI
InChI=1S/C17H17ClFN3O3/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9/h5,7-9H,1-4,6,20H2,(H,24,25)
IUPAC Name
7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
SMILES
NC1CCN(C1)C1=C(F)C=C2C(=O)C(=CN(C3CC3)C2=C1Cl)C(O)=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe risk or severity of bleeding can be increased when Clinafloxacin is combined with (R)-warfarin.
(S)-WarfarinThe risk or severity of bleeding can be increased when Clinafloxacin is combined with (S)-Warfarin.
2,4-thiazolidinedioneThe risk or severity of hypoglycemia can be increased when Clinafloxacin is combined with 2,4-thiazolidinedione.
4-hydroxycoumarinThe risk or severity of bleeding can be increased when Clinafloxacin is combined with 4-hydroxycoumarin.
AcarboseThe risk or severity of hypoglycemia can be increased when Acarbose is combined with Clinafloxacin.
AcenocoumarolThe risk or severity of bleeding can be increased when Clinafloxacin is combined with Acenocoumarol.
AcetohexamideThe risk or severity of hypoglycemia can be increased when Clinafloxacin is combined with Acetohexamide.
Adenovirus type 7 vaccine liveThe therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Clinafloxacin.
AICA ribonucleotideThe risk or severity of hypoglycemia can be increased when Clinafloxacin is combined with AICA ribonucleotide.
AlaproclateThe risk or severity of hypoglycemia can be increased when Alaproclate is combined with Clinafloxacin.
Food Interactions
Not Available

References

General References
Not Available
External Links
KEGG Drug
D02539
ChemSpider
54184
ChEBI
94459
ChEMBL
CHEMBL278255
Wikipedia
Clinafloxacin

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.445 mg/mLALOGPS
logP0.36ALOGPS
logP-0.42ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)5.45ChemAxon
pKa (Strongest Basic)9.63ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area86.87 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity92.51 m3·mol-1ChemAxon
Polarizability35.67 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 15, 2018 10:44 / Updated on November 02, 2018 09:14