Diabetic Peripheral Neuropathic Pain (DPN)

Also known as: Diabetic Peripheral Neuropathic Pain / Diabetic neuropathy / Diabetic Neuropathies

DrugDrug NameDrug Description
DB00776OxcarbazepineOxcarbazepine is an anticonvulsant agent generally used in the treatment of partial seizures in children and adults with epilepsy. It is a structural derivative of [carbamazepine], with an extra oxygen atom to the benzylcarboxamide group. The presence of an extra oxygen atom in the structure reduces the susceptibility of the drug to hepatic metabolism, leading to prolonged pharmacological action or half life of the drug. In addition, the structural modification reduces the drug's potential to cause serious anemias often seen with carbamazepine. The mechanism of action of oxcarbazepine is similar to that of carbamazepine, which involves the inhibition of voltage-gated sodium channels.
DB00230PregabalinPregabalin is an anticonvulsant drug used for neuropathic pain, epilepsy and generalized anxiety disorder.[A31161] Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin achieves antihyperalgesic activity by binding to the α2δ subunit of the voltage-dependent calcium channels [A31162]. Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release).[L1006][FDA Label] It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders [A31161].
DB06204TapentadolOpioid analgesic for treatment of moderate to severe pain. FDA approved on Nov 20, 2008.
DrugDrug NamePhaseStatusCount
DB06296Indantadol2Completed1
DB12664Indantadol2Completed1
DB00230Pregabalin2Completed2
DB12260Radiprodil2Completed1
DB11825Mirogabalin3Completed2
DB00121Biotin4Completed1
DB00122Choline4Completed1
DB00115Cyanocobalamin4Completed1
DB00476Duloxetine4Completed1
DB00158Folic acid4Completed1
DB00996Gabapentin4Completed1
DB11196Inositol4Completed1
DB02701Nicotinamide4Completed1
DB01783Pantothenic acid4Completed1
DB00230Pregabalin4Completed3
DB00165Pyridoxine4Completed1
DB00243Ranolazine4Terminated1
DB00140Riboflavin4Completed1
DB00152Thiamine4Completed1
DB00476DuloxetineNot AvailableNo Longer Available1