Identification
NameRiboflavin
Accession NumberDB00140  (NUTR00010, APRD00626, EXPT02760, DB09358)
TypeSmall Molecule
GroupsApproved, Nutraceutical, Vet Approved
Description

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]

Structure
Thumb
Synonyms
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
E101
Lactoflavin
Lactoflavine
Riboflavina
Riboflavine
Riboflavinum
Vitamin B2
Vitamin G
External IDs INS NO. 101(I) / NCI-0033298 / NSC-33298
Product Ingredients
IngredientUNIICASInChI KeyDetails
Riboflavin 5'-phosphate sodium20RD1DZH99 6184-17-4LQVGUKOCMOKKJU-QPVGXXQTSA-MDetails
Riboflavin 5'-phosphate sodium anhydrous957E53WV42 130-40-5OHSHFZJLPYLRIP-BMZHGHOISA-MDetails
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
PhotrexaSolution / drops1.46 mg/mLOphthalmicAvedro, Inc.2016-04-15Not applicableUs
Photrexa ViscousSolution / drops1.46 mg/mLOphthalmicAvedro, Inc.2016-04-15Not applicableUs
Riboflavin Inj 50mg/mlSolution50 mgIntramuscular; IntravenousKripps Pharmacy Ltd.1979-12-31Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
B-2 Caps 100mgCapsule100 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
B2 Tab 100mgTablet100 mgOralVita Health Products Inc1979-12-312002-07-31Canada
Riboflavin 5 Phosphate Cap 50mgCapsule50 mgOralThorne Research Inc.1985-12-312001-07-13Canada
Riboflavin Tab 10mgTablet10 mgOralSwiss Herbal Remedies Ltd.1971-12-311999-09-09Canada
Riboflavin Tab 5mgTablet5 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Riboflavin-S Tab 25mgTablet25 mgOralNutri West Products Ltd.1993-12-311997-08-05Canada
Vit B2 Ctr Srt 200mgTablet, extended release200 mgOralBioenergy Inc.1979-12-311998-06-03Canada
Vita-flavine Cap 100mgCapsule100 mgOralLes Laboratoires Vachon Inc.1991-12-312001-08-07Canada
Vitamin B-2Capsule100 mgOralSisu Inc.2001-09-012006-07-31Canada
Vitamin B-2 50 Mg TabletsTablet50 mgOralGeneral Nutrition Canada Inc.1997-04-182006-08-03Canada
Vitamin B-2 Riboflavin 100mg CapsulesCapsule100 mgOralAlbi Naturals1999-04-302009-07-15Canada
Vitamin B2 100 mgCapsule100 mgOralFlora Manufacturing And Distributing Ltd.2002-03-152004-08-04Canada
Vitamin B2 100mgTablet100 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Vitamin B2 Tab 100mgTablet100 mgOralQuest Vitamins A Div Of Purity Life Health Products1978-12-312001-07-06Canada
Vitamin B2 Tab 4mg USP ChewableTablet4 mgOralLab Gernetic Int Ltee1985-12-311997-02-21Canada
Vitamin B2 Tablets 100mgTablet100 mgOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
Unapproved/Other Products Not Available
International Brands
NameCompany
BisulaseNot Available
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Active FeTabletOralGm Pharmaceuticals2013-11-11Not applicableUs
Adult Infuvite Multiple VitaminsInjection, solutionIntravenousSandoz2005-05-18Not applicableUs
AlertonicElixirOralOdan Laboratories Ltd1995-12-31Not applicableCanada
Allbee With C 550 CapCapsuleOralWhitehall Robins Inc.1994-12-312003-08-01Canada
Allbee With Vitamin C CapCapsuleOralWhitehall Robins Inc.1994-12-312000-07-26Canada
Alsimine W Vitamins A DCapsule; LiquidOralAlsi Cie Ltee1978-12-312003-05-21Canada
Am CapsCapsuleOralNew Vision Nutritionals Company1998-10-012002-11-20Canada
AntlervironCapsuleOralClassical Remedia LtdNot applicableNot applicableCanada
AppedrineTabletOralChattem, Inc.1975-12-312004-07-08Canada
B 50 CapsulesCapsuleOralRheingold Food International Ltd.1987-12-312007-07-26Canada
B 6 PlusTabletOralAnabolic Laboratories Inc.1967-12-312004-03-15Canada
B C Antistress CapCapsuleOralLes Laboratoires Bio SantÉ Inc.1992-12-311996-09-10Canada
B Complex 25mg Vitamin SupplementTabletOralGarden State Nutritionals1998-08-312000-06-07Canada
B Complex 50 Vitamin CapCapsuleOralBioforce Canada Inc.1994-12-311997-07-22Canada
B Complex 50+ CapletTabletOralHealth Wise Nutrition Inc.1994-12-312002-07-18Canada
B Complex 500 TabTabletOralNobel Pharm Enr.1981-12-311998-08-14Canada
B Complex Plus C 300mg TabTabletOralNutricorp International2000-08-012009-08-05Canada
B Complex TabletsTabletOralGolden Neo Life Diamite International, Limited1979-12-312000-08-06Canada
B Complex W C and B12 InjLiquidIntramuscular; IntravenousE L Stickley And Co Ltd.1963-12-311996-09-09Canada
B Complex W C Forte CapCapsuleOralEverest Pharmaceuticals Ltd.1980-12-311999-07-14Canada
B Complex W Vit C W Non-med Yeast&liver TabTabletOralPharmavite1991-12-311997-09-04Canada
B Complex W Vitamin C Fortis CapCapsuleOralShoppers Drug Mart Inc.1984-12-311998-08-14Canada
B Complex With C 300mgCapsuleOralVita Health Products Inc1985-12-312008-08-05Canada
B Complex With C 300mg TabTabletOralPharmavite1987-12-312005-07-15Canada
B Complex With C 550mgCapsuleOralVita Health Products Inc1990-12-312002-07-31Canada
B Compound 50mg TabTabletOralGahler Enterprises Ltd.1987-12-312009-09-28Canada
B Plus C 300mg Timed ReleaseTablet, extended releaseOralVita Health Products Inc1981-12-312008-08-05Canada
B Stress C + Iron & ViteTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1990-12-312004-07-26Canada
B Totum 500TabletOralDesbergers LtÉe, Division Of Technilab Inc.1966-12-311999-09-17Canada
B VirolElixirOralRolmex International Inc.1975-12-312008-07-09Canada
B Vitamin Compound With B12 ThunasLiquidOralThuna Herbal Remedies Ltd.1984-05-312002-10-16Canada
B With C 500 CapCapsuleOralPharmetics (2011) Inc.1995-12-312006-07-27Canada
B-100 CapsCapsuleOralNow Foods2005-05-192008-07-11Canada
B-100 Complex TabletsTablet, extended releaseOralViva Pharmaceutical Inc.2001-06-052009-12-18Canada
B-100 Hi Potency B Vitamins TabTabletOralNatrol, Inc.1994-12-312009-05-07Canada
B-100 Vitamin SupplementTablet, extended releaseOralGarden State Nutritionals1998-09-222000-06-07Canada
B-2 100mg With C 20mgTabletOralGahler Enterprises Ltd.1986-12-312006-07-26Canada
B-50 ComplexTabletOralVita Health Products Inc1977-12-312004-07-26Canada
B-50 Complex TabTabletOralVita Health Products Inc1988-12-311998-07-22Canada
B-50 Hi Potency B Vitamins TabTabletOralNatrol, Inc.1994-12-312006-09-26Canada
B-comboInjectionIntramuscularPerdido Key Health And Wellness Inc2015-11-23Not applicableUs
B-complexTabletOralEnrich International1999-11-112001-09-28Canada
B-complex 100TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
B-complex 50TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
B-complex TabTabletOralNatures Sunshine Products, Inc.1995-12-312009-08-07Canada
B-complex TabletsTabletOralShaklee Corporation1983-12-312000-01-24Canada
B-complex With Vitamin C, Biotin, Folic AcidTabletOralWn Pharmaceuticals Ltd.2001-11-232009-09-28Canada
B-complex-50 TabTabletOralJr Carlson Labs Inc1998-10-252005-09-15Canada
B-plexTabletOralWn Pharmaceuticals Ltd.1999-10-202000-01-28Canada
B-plex 100Injection, solutionIntramuscular; IntravenousMerit Pharmaceuticals2012-01-01Not applicableUs
B-plus - TabTabletOralChampion's Choice Advanced Nutrition Inc.1997-06-111999-08-28Canada
B50 B Complex TabTabletOralNutristar Health Products (1987) Inc.1983-12-311996-09-09Canada
B50 ComplexCapsuleOralPreferred Nutrition Inc.2003-10-292005-08-04Canada
B6 Plus TabTabletOralVita Health Products Inc1979-12-312002-08-01Canada
BacminTablet, coatedOralMarnel Pharmaceuticals, Llc2000-04-01Not applicableUs
Balanced B 125 SrtTablet, extended releaseOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
Balanced B-100 B-complex Vitamins TabTabletOralPharmavite1991-12-312003-07-30Canada
Balanced B-100 Timed ReleaseTabletOralPharmavite2000-10-242005-07-15Canada
Balanced B-50 B-complex Vitamins TabTabletOralPharmavite1995-12-312000-08-24Canada
Balanced B-50 B-complex Vitamins, Timed ReleTabletOralPharmavite1995-12-312006-07-05Canada
Balanced B-50 ComplexTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Balanced B-complex Vit + Vit C&e TabTabletOralPharmavite1991-12-312006-07-05Canada
Balanced B100TabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Balanced B50 ComplexTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Beminal W C Fortis InjPowder, for solutionIntramuscular; IntravenousAyerst Laboratories1951-12-311996-09-10Canada
Beminal With C Fortis CapCapsuleOralWyeth Ayerst Canada Inc.1994-12-312001-08-03Canada
Beminal With C Fortis PwsPowder, for solutionIntravenousWyeth Ayerst Canada Inc.1994-12-312000-08-02Canada
Bev 29 TabTabletOralBeverly International Nutrition1987-12-311998-08-01Canada
Bev B-150TabletOralBeverly International Nutrition1986-12-311998-08-01Canada
Bio-fenCapsuleOralLisa & Gerry Freundl2001-10-102006-09-28Canada
Biovim TabTabletOralLe Naturiste J.M.B. Inc.1977-12-312008-07-31Canada
BiovitaGranuleOralIldong Pharmaceutical Co., Ltd.2015-06-03Not applicableUs
Bugs Bunny and Friends Multiple VitaminsTabletOralBayer Inc Consumer Care1996-12-312004-04-15Canada
Bugs Bunny Chew Multi Vit Plus IronTabletOralMiles Inc. Pharmaceutical Division1983-12-311996-09-09Canada
C-B ComplexTabletOralAvacare, Division Of Jeunique International Inc.1984-12-311996-09-09Canada
C-nate DHACapsule, gelatin coatedOralCenturion Labs2013-01-01Not applicableUs
C.A.G. TabTabletOralNutrition For Life International1996-11-272000-08-11Canada
C.R.T. X Multivitamin & Mineral Powder MixPowderOralMetaform Ltd.1998-12-082001-07-23Canada
Carbassist TabletsTabletOralWyeth Ltd.1978-12-312006-07-24Canada
Cc IIPowderOralAdded Dimensions1997-03-262006-09-25Canada
Cda-21 Vitamins With Non-medicinal Probiotic ComplexCapsuleOralRx Vitamins Inc.2006-08-012007-10-25Canada
Cedevita Plus Vitamin SupplementPowderOralPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.Not applicableNot applicableCanada
Cedevita Sugar-free Vitamin SupplementPowderOralPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.Not applicableNot applicableCanada
Central-vite 18 EssentialTabletOralVita Health Products Inc1998-04-242002-07-31Canada
Century CompleteTabletOralVita Health Products Inc1998-03-172002-07-31Canada
Chela Potassium PlusTabletOralNu Life Nutrition Ltd.1988-12-312000-03-03Canada
Chela-chromium 200TabletOralNu Life Nutrition Ltd.1986-12-312000-03-03Canada
Chew.multiple Vits.with Extra C for ChildrenTabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable Multiple Vit Plus Iron for ChildrenTabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable Multiple Vitamins for ChildrenTabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable Multiple Vitamins Plus Extra CTabletOralRandle Pharmaceutical Inc.1993-12-311999-09-03Canada
Chewable Multiple Vitamins Plus Iron TabTabletOralRandle Pharmaceutical Inc.1993-12-311999-09-03Canada
Chewable Multiple Vitamins TabTabletOralRandle Pharmaceutical Inc.1993-12-311999-09-03Canada
Chewable MultivitaminsTabletOralWn Pharmaceuticals Ltd.2002-05-312008-07-17Canada
Chewable Multivitamins Plus IronTabletOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Children Choice Multivit Chewable TabTabletOralSwiss Herbal Remedies Ltd.1990-12-312009-08-04Canada
Children Choice Multivitamin W Iron Chew TabTabletOralSwiss Herbal Remedies Ltd.1991-12-312009-08-04Canada
Children's Chewable Multi Vit W IronTabletOralShoppers Drug Mart Inc.1982-12-311997-08-15Canada
Children's Chewable Multi VitaminsTabletOralShoppers Drug Mart Inc.1982-12-311997-08-15Canada
Children's Chewable Multi Vitamins With Iron TabletsTabletOralVita Health Products Inc1998-05-202008-08-05Canada
Children's Chewable Multi-vitaminTabletOralWn Pharmaceuticals Ltd.2000-03-012007-08-07Canada
Children's Chewable Multi-vitamin Complete With MineralsTabletOralWn Pharmaceuticals Ltd.2000-03-012001-07-18Canada
Children's Chewable Multiple Vit.plus IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada
Children's Chewable Multiple Vitamins - TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada
Children's Chewable Multiple Vitamins (chewable Tablets)TabletOralPharmetics (2011) Inc.1999-08-162009-07-30Canada
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)TabletOralPharmetics (2011) Inc.1999-08-162009-07-30Canada
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)TabletOralPharmetics (2011) Inc.1999-08-162009-07-30Canada
Children's Vitamins ChewableTabletOralVita Health Products Inc1990-12-312002-07-31Canada
Children's Vitamins W Iron ChewableTabletOralVita Health Products Inc1990-12-312002-07-31Canada
Childrens Chew Multi Vitamin TabTabletOralNutristar Health Products (1987) Inc.1983-12-311996-09-09Canada
Childrens Chewable Multiple VitaminsTabletOralKsl Pharmaceuticals1994-12-311999-08-12Canada
Childrens Chewable Multiple Vitamins Plus FeTabletOralKsl Pharmaceuticals1994-12-312000-08-29Canada
Childrens Chewable Multiple Vitamins TabTabletOralPharmavite1987-12-312000-08-24Canada
Childrens Chewable MultivitaminsTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Childrens Chewable Multivitamins W IronTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Childrens Chewable Vitamin TabTabletOralPharmetics (2011) Inc.1993-12-312006-07-27Canada
Childrens Chewable VitaminsTabletOralD.C. Labs Limited1974-12-312003-07-11Canada
Childrens Multiple Vit and Min Chew TabTabletOralCountry Health Laboratories Ltd.1982-12-312008-07-17Canada
Citranatal DHATabletOralMission Pharmacal2007-11-20Not applicableUs
Citranatal RxTabletOralMission Pharmacal2014-08-11Not applicableUs
Coenzyme Q10 Isotonix Vitamin and Mineral SupplementPowderOralMarket America2002-06-042008-09-04Canada
Complete Mega BTabletOralGahler Enterprises Ltd.1985-12-312001-07-26Canada
Complete Multivitamins and Minerals for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
Complete Multivitamins and Minerals Tablets Timed ReleaseTablet, extended releaseOralPharmetics (2011) Inc.1999-07-262009-07-30Canada
Complex 5 - PwrPowderOralAst Research1996-03-151998-08-10Canada
Complex-75CapsuleOralFrega Inc.1990-12-311999-08-06Canada
Complexe B 75mgTabletOralPharmalab Inc.1994-12-312001-07-30Canada
Complexe B Compose 75TabletOralLes Laboratoires Bio SantÉ Inc.1983-12-311996-09-10Canada
Complexe B-75TabletOralFrega Inc.1998-06-292008-02-13Canada
Concept DHACapsule, liquid filledOralUs Pharmaceutical Corporation2009-06-24Not applicableUs
Concept ObCapsuleOralUs Pharmaceutical Corporation2009-01-01Not applicableUs
Croq-vit Pour EnfantsTabletOralNutrivac Ltee1987-12-311996-09-09Canada
D'pantothenic Acid-B1-B2 TabTabletOralHealth Thru Herbs Inc.1985-12-312001-06-21Canada
Daily Energy Brand B-complexCapsuleOralEnzymatic Therapy, Inc.2004-01-012008-07-25Canada
Derma-forceCapsuleOralPrairie Naturals1997-04-012006-09-20Canada
Dexatrim TabletsTabletOralChattem, Inc.1996-09-092005-06-29Canada
Dia-viteTabletOralR & D Laboratories Inc.1997-08-132003-07-16Canada
DiaplexTabletOralNephro Tech, Inc.2002-07-102004-07-23Canada
Dynam Ampoule Et TabletLiquid; TabletOralCardinaux Enrg Les Produits Naturels1989-12-311996-09-09Canada
E & I FormulaeCapsuleOralEnrich InternationalNot applicableNot applicableCanada
E.S.T. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Efferlife Multivitamins and MineralsTablet, effervescentOralNaturale Science Inc.2001-10-012006-10-10Canada
Enviroflex - TabTabletOralEnviro Tech International Canada1997-09-151999-07-26Canada
EscaviteTablet, chewableOralGm Pharmaceuticals2012-02-01Not applicableUs
Essential B TabletsTabletOralGeneral Nutrition Canada Inc.1997-04-182006-08-03Canada
Everyday Multiple VitaminsTabletOralD.C. Labs Limited1972-12-312003-07-11Canada
Everyday Multiple Vitamins With IronTabletOralD.C. Labs Limited1972-12-312003-07-11Canada
Extra P.N. Vitamin-mineral Drink MixPowderOralChanges InternationalNot applicableNot applicableCanada
Ez-flexTabletOralMetagenics, Inc.1997-06-302007-09-07Canada
Feminique W Iron and Calcium TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1992-12-311998-08-13Canada
Ferra Naka Plus VitaminsLiquidOralNaka Sales Ltd.1999-05-052001-07-23Canada
Flinstones Multiple Plus IronTabletOralMiles Inc. Pharmaceutical Division1971-12-311996-09-09Canada
Flintstones Multiple VitaminsTabletOralBayer Inc Consumer Care1995-12-312004-06-28Canada
Flintstones Multiple Vitamins Plus IronTabletOralBayer Inc Consumer Care1995-12-312004-06-28Canada
Flintstones Multiple Vitamins TabTabletOralMiles Inc. Pharmaceutical Division1970-12-311996-09-09Canada
Flintstones W Extra C TabTabletOralMiles Inc. Pharmaceutical Division1981-12-311996-09-09Canada
Floradix Formula LiqLiquidOralFlora Manufacturing And Distributing Ltd.1979-12-312002-06-05Canada
Floravit - SyrSyrupOralFlora Manufacturing And Distributing Ltd.1995-05-282009-08-05Canada
FlorivaTablet, chewableOralBon Geo Pharmaceuticals, Inc.2015-09-10Not applicableUs
Floriva PlusSolution / dropsOralBon Geo Pharmaceuticals, Inc.2015-12-28Not applicableUs
Folcaps Care OneCapsule, gelatin coatedOralMidlothian Laboratories2009-05-01Not applicableUs
Foltabs PrenatalTabletOralMidlothian Laboratories2009-01-01Not applicableUs
For Kids Only Chewable Multivit. Plus IronTabletOralKsl Pharmaceuticals1996-12-312002-07-31Canada
For Kids Only Chewable Multivitamins - TabTabletOralKsl Pharmaceuticals1996-12-312002-07-31Canada
Formula Adr-vitamin B2,b6 W Calpan TabTabletOralMetagenics, Inc.1996-12-302006-08-14Canada
Formula CnCapsuleOralBalance Plus, Inc.2000-02-092004-08-17Canada
Formula D.S.TabletOralGolden Pride InternationalNot applicableNot applicableCanada
Formula DprCapsuleOralBalance Plus, Inc.2000-03-082004-08-17Canada
Formula Fm Vitamins & Minerals TabTabletOralMetagenics, Inc.1997-01-272001-10-05Canada
Formula LfTabletOralNumark Laboratories, Inc.2003-12-152009-07-31Canada
Formula OCapsuleOralGeneral Nutrition Canada Inc.1997-09-122005-08-05Canada
Formula O-care Vitamin and Mineral SupplementTabletOralFor Mor International Inc.2000-03-252002-06-25Canada
Formula Pro-BCapsuleOralBalance Plus, Inc.2000-03-082004-08-17Canada
Fortamines 10 CapsulesCapsuleOralRougier Pharma Division Of Ratiopharm Inc1974-12-311999-09-27Canada
Fortamines-10 ComprimesTabletOralRougier Pharma Division Of Ratiopharm Inc1979-12-312003-09-22Canada
Fortaplex InjLiquidIntramuscular; IntravenousKripps Pharmacy Ltd.1979-12-31Not applicableCanada
Fortistress TabTabletOralSantÉ Naturelle (Ag) LtÉe1993-12-312001-07-06Canada
Forty Plus Vitamin SupplementTabletOralGarden State Nutritionals1998-10-162000-06-07Canada
Garfield Chewable Multivits Plus Iron TabTabletOralWhitehall Robins Inc.1993-12-312000-07-26Canada
Gemvites Jr Tab ChewableTabletOralPharmavite Laboratories (1987) Inc.1969-12-311999-10-19Canada
Geritol LiquidLiquidOralGlaxosmithkline Inc1992-12-312002-07-31Canada
Gestamine ComprimesTabletOralLab Nadeau LtÉe, Division Of Technilab Inc.1957-12-311999-09-28Canada
Gesticare DHAKitJazz Pharmaceuticals Commercial Corp.2008-10-01Not applicableUs
Globucel - MethodeCapsuleOralLes Laboratoires Swisse Inc.1997-08-302009-08-05Canada
Glyco-aide TabTabletOralAvant Garde, Les SupplÉments1995-12-311998-07-08Canada
Harvest Of Values All B Complex TabTabletOralHillestad Pharmaceuticals Usa1997-09-242009-09-22Canada
Healthy Mamabe Well Rounded Be Well RoundedTablet, film coatedOralMATERNAL SCIENCE, LLC2013-07-09Not applicableUs
Hemarexin AmpLiquidOralLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.1958-12-311999-01-22Canada
Hemarexin Liquid and Drinkable AmpoulesLiquidOralSabex Inc1997-08-192009-11-26Canada
Hemarexin TabTabletOralLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.1997-12-172004-08-03Canada
Hemenatal OBTabletOralWh Nutritionals, Llc2012-03-08Not applicableUs
Hi Potency B Complex W Chelated MineralsTabletOralKlaire Labs Inc.1984-12-312004-01-19Canada
Hi Potency B52 B Complex TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Hi Potency Balanced B-100 Complex - TabTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Hi Potency Stress B Tension With CTabletOralLee Adams Laboratories1982-12-312010-08-05Canada
High Potency Vitamin B Complex + C TabTabletOralVita Health Products Inc1996-10-112004-07-26Canada
Hill.viteTabletOralHillestad Pharmaceuticals Usa2001-11-142009-09-22Canada
Homosistrol CapsulesCapsuleOralMacromed Pharmicia Inc.Not applicableNot applicableCanada
Hypo Vites TabTabletOralPharmetics (2011) Inc.1977-12-312006-07-27Canada
Iberet 500Tablet, extended releaseOralAbbott1965-12-312007-07-31Canada
IcapsTabletOralAlcon, Inc.1994-12-312009-04-24Canada
Icaps Time ReleaseTabletOralAlcon, Inc.1997-06-202001-08-14Canada
Inatal AdvanceTablet, coatedOralNnodum Pharmaceuticals2005-06-10Not applicableUs
Inatal UltraTablet, coatedOralNnodum Pharmaceuticals2005-06-20Not applicableUs
Infa Drops MultivitaminsLiquidOralVita Health Products Inc1998-05-202002-07-31Canada
Infant Multivitamin DropsSolution / dropsOralGeneral Nutrition Canada Inc.2002-10-202005-08-05Canada
Infantol DropsSolution / dropsOralChurch & Dwight Company, Inc.1988-12-312008-07-30Canada
Infuvite Adult Multiple VitaminsInjection, solutionIntravenousSandoz2005-05-18Not applicableUs
Insur-all Vitamin SupplementTabletOralGarden State Nutritionals1998-10-162000-06-07Canada
Integra PlusCapsuleOralUs Pharmaceutical Corporation2009-04-27Not applicableUs
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1996-07-232002-07-29Canada
Iron Polysaccharides Folic Acid DHATablet, film coatedOralVirtus Pharmaceuticals2013-12-202017-08-11Us
Isotonix Advanced B-complex Vitamins With Potassium and MagnesiumPowderOralMarket America2004-01-272009-07-20Canada
Isotonix Calcium Plus FormulaPowderOralMarket America1998-12-172001-06-28Canada
Isotonix Vitamin B-folic Acid-mineral SupplePowderOralMarket America1996-12-312004-07-12Canada
Itabs PlusTabletOralVita Health Products Inc2000-01-012002-07-31Canada
Kanga Sport Vitamins B & C Plus MineralsTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-B Vitamin B Group + CTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-kid Multi-vitamin & MineralTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-V Multivitamins & MineralsTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kenwood Liquid SupplementLiquidOralKenwood Laboratories (Division Of Bradley Pharmaceuticals)Not applicableNot applicableCanada
Kid's Choice Children's Chewable Vitamins - TabTabletOralVita Health Products Inc1998-04-162002-07-31Canada
Kids Stuff TabletsTabletOralVita Health Products Inc1998-04-202002-07-31Canada
Kids Stuff With Iron TabletsTabletOralVita Health Products Inc1998-04-202002-07-31Canada
Kimchi Vitamin Chewable MultivitaminTablet, chewableOralTobico2010-03-18Not applicableUs
KindervitesSolution / dropsOralHerbalife International Of America1984-12-312002-09-17Canada
L.G.I.T.CapsuleOralMorinda Canada1999-12-152001-07-23Canada
Leritone JuniorCapsuleOralInstitut De Recherche Biologique Yves Ponroy Canada Inc.1998-12-072004-12-23Canada
Lipo-B-C TabTabletOralMetagenics, Inc.1989-12-311996-10-02Canada
Liqui B ComplexLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui B Complex PlusLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui Infant VitaminsLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui VitaLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liquid B Complex 50LiquidOralJamieson Laboratories Ltd1985-12-311997-08-13Canada
Livron Plus AmpouleLiquidOralMedic Laboratory LtÉe1980-12-311996-09-09Canada
Livron Plus TabTabletOralMedic Laboratory LtÉe1980-12-311996-09-09Canada
Low Potency B Complex TabTabletOralFlora Manufacturing And Distributing Ltd.1983-12-311999-10-18Canada
Lysamine Diet Supp Amp-tabLiquid; TabletOralWelcker Lyster Ltd., Division Of Technilab Inc.1983-12-311999-09-17Canada
M.V.I. 12LiquidIntravenousAventis Pharma Ltd.1992-12-312002-07-29Canada
M.V.I. PaediatricLiquidIntravenousAventis Pharma Ltd.1988-12-312002-07-29Canada
M.V.I. PediatricInjection, powder, lyophilized, for solutionIntravenousHospira Worldwide, Inc.1983-04-06Not applicableUs
Maltlevol 12 LiqLiquidOralCarter Horner Corp.1978-12-312002-02-07Canada
Maltlevol LiqLiquidOralCarter Horner Corp.1980-12-312005-03-21Canada
Maxi 10 TabTabletOralDesbergers LtÉe, Division Of Technilab Inc.1979-12-311999-09-17Canada
Maxi 6 LiqLiquidOralDesbergers LtÉe, Division Of Technilab Inc.1980-12-311999-09-17Canada
Mega 13 Multivitamin FormulaCapsuleOralVita Health Products Inc1988-12-311998-07-22Canada
Megavites TabTabletOralIcn Pharmaceuticals1973-12-312005-04-26Canada
Meplex T 750TabletOralMedic Laboratory LtÉe1966-12-311996-09-09Canada
MethaverCapsuleOralSterling Knight Pharmaceuticals, Llc2015-11-24Not applicableUs
Mini-B TabTabletOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Mor-vites TabTabletOralPharmetics (2011) Inc.1992-12-312006-07-27Canada
Multi - N.T.O.x Formula - TabTabletOralAbundance Naturally LtdNot applicableNot applicableCanada
Multi 12 InjectionLiquidIntravenousSandoz Canada Incorporated1994-12-31Not applicableCanada
Multi BTabletOralSeroyal International Inc.1988-12-312009-07-06Canada
Multi Enfants TabTabletOralVitalab1992-12-311997-07-22Canada
Multi Nt-OXTabletOralAbundance Marketing Ltd.1999-02-012001-07-10Canada
Multi RolLiquid; TabletOralRolmex International Inc.1975-12-311997-08-08Canada
Multi Vitamin - MineralTabletOralEnrich International1999-11-112001-09-28Canada
Multi Vitamin & MineralsTabletOralWn Pharmaceuticals Ltd.2002-01-042008-07-17Canada
Multi Vitamin and FluorideSolution / dropsOralLibertas Pharma, Inc.2011-05-21Not applicableUs
Multi Vitamin Drops With FluorideSolution / dropsOralSeton Pharmaceuticals2014-04-18Not applicableUs
Multi Vitamin Drops With Fluoride and IronSolution / dropsOralSeton Pharmaceuticals2014-04-18Not applicableUs
Multi Vitamin Drops With Fluoride With IronLiquidOralStratus Pharmaceuticals2014-09-01Not applicableUs
Multi Vitamin Plus IronTabletOralWn Pharmaceuticals Ltd.2002-03-132009-09-28Canada
Multi Vitamin With FluorideTablet, chewableOralQualitest2009-10-092016-10-13Us
Multi Vitamin-mineral FormulaTabletOralVita Health Products Inc1997-04-031998-01-16Canada
Multi Vitamin, Iron and FluorideSolution / dropsOralMayne Pharma2011-05-212019-10-31Us
Multi Vitamines - LiqLiquidOralLand Art Inc.1995-12-312008-06-26Canada
Multi Vitamins & MineralsTabletOralWn Pharmaceuticals Ltd.2000-01-122001-04-12Canada
Multi Vite Liq AdultLiquidOralPharmetics (2011) Inc.1981-12-312001-07-26Canada
Multi Vite Liq JuniorLiquidOralPharmetics (2011) Inc.1981-12-312001-07-26Canada
Multi-11SolutionIntravenousSandoz Canada Incorporated2002-01-28Not applicableCanada
Multi-12 PediatricLiquidIntravenousSabex Inc1998-04-092009-11-26Canada
Multi-12/k1 PediatricLiquidIntravenousSandoz Canada Incorporated2000-11-07Not applicableCanada
Multi-min Electro C Pow Plus B2Granule, effervescentOralQuest Vitamins A Div Of Purity Life Health Products1988-12-311998-07-15Canada
Multi-vit With FluorideSolutionOralA S Medication Solutions1997-04-182017-06-20Us
Multi-vit With Fluoride and IronSolutionOralQualitest1998-01-07Not applicableUs
Multi-vitaminLiquidOralLLC Federal Solutions2013-08-12Not applicableUs
Multi-vitamin Dietary SupplementTabletOralGarden State Nutritionals1998-09-222000-06-07Canada
Multi-vitamin Drops With Fluoride and IronLiquidOralMethod Pharmaceuticals2017-02-24Not applicableUs
Multi-vitamin FluorideLiquidOralStratus Pharmaceuticals2014-09-01Not applicableUs
Multi-vitamin Fluoride and Iron DropsSolutionOralBoca Pharmacal, Inc.2011-04-202015-12-29Us
Multi-vitamin Fluoride DropsSolutionOralH.J. Harkins Company2011-05-04Not applicableUs
Multi-vitamin With FluorideTablet, chewableOralGolden State Medical Supply2010-12-17Not applicableUs
Multi-vitamines Enfants ComprimeTabletOralHerbes Universelles Inc.1997-09-292009-07-15Canada
Multi-vitaminsTabletOralWn Pharmaceuticals Ltd.1999-12-222008-07-17Canada
Multi-vitamins With MineralsTabletOralWn Pharmaceuticals Ltd.2001-04-122009-09-28Canada
Multiple Vitamin Plus Minerals TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamin TabTabletOralAdams Laboratories1983-12-312009-12-02Canada
Multiple VitaminsTabletOralGfr Pharma Ltd.2002-10-102007-07-20Canada
Multiple Vitamins & Minerals TabletsTabletOralPharmetics (2011) Inc.2002-12-182006-07-27Canada
Multiple Vitamins and Minerals TabTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Multiple Vitamins Plus Iron for WomenTabletOralPharmetics (2011) Inc.1999-08-162006-07-27Canada
Multiple Vitamins Plus Iron TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamins TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamins W Minerals TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1976-12-312002-07-31Canada
Multiple Vitamins With IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1987-12-312002-07-31Canada
Multiple Vitamins With Minerals TabletsTabletOralPharmetics (2011) Inc.1999-07-162009-07-30Canada
MultisolLiquidOralLes Laboratoires Vachon Inc.1979-12-311997-02-06Canada
Multivit Et Fer Ampoules Et ComprimesLiquid; TabletOralNobel Pharm Enr.1988-12-311998-08-14Canada
Multivit-liqLiquidOralPharmalab Inc.1995-12-311997-08-08Canada
MultivitaminTabletOralLaboratoires Confab IncNot applicableNot applicableCanada
Multivitamin Drops With FluorideSolution / dropsOralSancilio & Company, Inc.2017-04-10Not applicableUs
Multivitamin With FluorideTablet, chewableOralPure Tek Corporation2011-06-01Not applicableUs
MultivitaminesTabletOralRolmex International Inc.1998-05-112007-07-09Canada
Multivitamines Et MinerauxTabletOralLe Groupe M. Vachon Inc.Not applicableNot applicableCanada
Multivitamines Et Mineraux Junior RegulierTabletOralLaboratoire Riva Inc1996-10-082008-07-30Canada
Multivitamines Et Mineraux Reguliers / Regular Multivitamins and MineralsTabletOralVita Health Products Inc1998-10-062004-07-26Canada
Multivitamines Plus Fer Pour Enfants (chewable Tablets)TabletOralLaboratoire Lalco Inc.1998-07-032002-09-05Canada
Multivitamines Pour Enfants (chewable Tablets)TabletOralLaboratoire Lalco Inc.1998-07-032002-09-05Canada
Multivitamins and Minerals - CompleteTabletOralVita Health Products Inc2000-02-012006-07-31Canada
Multivitamins and Multiminerals Formula Regular TabletTabletOralPharmetics (2011) Inc.2001-11-222009-07-30Canada
Multivitamins for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
Multivitamins W IronTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
MvcTablet, chewableOralSancilio & Company Inc.2009-12-20Not applicableUs
Mvc-fluorideTablet, chewableOralSancilio & Company Inc.2011-12-07Not applicableUs
Myhephron Dialysis and Stress SupplementCapsuleOralMartin Ekwealor Pharmaceu2016-08-01Not applicableUs
Mynephrocaps Dialysis/stress Vitamin SupplementCapsuleOralMartin Ekwealor Pharmaceuticals, Inc.2013-12-16Not applicableUs
N.E.U. ComplexTabletOralAbundance Marketing Ltd.2000-12-042004-06-30Canada
Nata KompleteTabletOralWh Nutritionals, Llc2011-06-252016-12-06Us
NatafortTabletOralMission Pharmacal2011-08-25Not applicableUs
NataviteTabletOralSchein Pharmaceutical Canada Inc.1997-07-292004-07-26Canada
Neo Bex ElixirElixirOralNeolab Inc1984-12-311997-08-12Canada
Neo Vites TabTabletOralNeolab Inc1979-12-311997-08-12Canada
Neo-bexTabletOralNeolab Inc1987-12-312005-08-02Canada
Neo-bex InjectableSolutionIntramuscular; IntravenousBrostel Inc.1951-12-31Not applicableCanada
Neo-vites & Minerals TabTabletOralNeolab Inc1987-12-311997-08-12Canada
NephrocapsCapsule, liquid filledOralCardinal Health2010-01-14Not applicableUs
Nutrifer Plus TabletsTabletOralWyeth Ayerst Canada Inc.1994-12-311999-09-23Canada
Nutrilite Double XTabletOralNutrilite, A Division Of Access Business Group, Llc2002-12-152008-06-24Canada
Nutrol-B-complexTabletOralRolmex International Inc.1999-06-282008-07-09Canada
O-cal Fa MultivitaminTabletOralPharmics, Inc.1970-01-15Not applicableUs
O-cal Prenatal VitaminTabletOralPharmics, Inc.2002-01-23Not applicableUs
OnccorTabletOralSimone Protective Pharmaceuticals, Inc.Not applicableNot applicableCanada
One A Day Advance AdultsTabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance Adults 50+TabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance FemTabletOralBayer Inc Consumer Care1999-03-012001-02-22Canada
One A Day TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Orange Flavored Crystal Chews TabTabletOralJeunique International Inc.1998-02-172006-07-20Canada
Orifer FTabletOralSanofi Aventis1995-12-312007-11-22Canada
Original Bioscal Forte Multi-vitamin Supplement CapsulesCapsuleOralCarram Inc.1997-05-071999-07-30Canada
Orti BCapsuleOralSeroyal International Inc.1983-12-312008-10-09Canada
P.N.P. Vitamin DrinkLiquidOralChanges InternationalNot applicableNot applicableCanada
P.R.O. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Paramettes Chewable Multivitamins Plus IronTabletOralWyeth Ayerst Canada Inc.1994-12-312000-08-02Canada
Paramettes Chewable Multivits With Iron TabTabletOralWhitehall Robins Inc.1994-12-311996-09-09Canada
Paramettes Multivits Plus Iron Tab (teens)TabletOralWhitehall Robins Inc.1993-12-311996-09-09Canada
Paramettes SyrupSyrupOralWyeth Ayerst Canada Inc.1994-12-312002-07-31Canada
Pediatric Infuvite Multiple VitaminsInjection, solutionIntravenousSandoz2001-02-21Not applicableUs
Pediatric Infuvite Multiple Vitamins for InfusionInjection, solutionIntravenousSandoz2001-02-21Not applicableUs
Permathene-12 - CapletTabletOralCca Industries, Inc1995-12-312000-12-14Canada
Phosthenine Vitamines Et Fer (ampoules Buvable)LiquidOralLaboratoires Cortunon Inc.1997-01-232007-07-23Canada
Phytofortis + Calcium A-DLiquid; TabletOralPhyto Health Corporation1983-12-312003-11-27Canada
Phytoplex B LiqLiquidOralPhyto Health Corporation1973-12-312004-08-30Canada
PhytopureCapsuleOralLaboratoire Lalco Inc.1993-12-312001-10-15Canada
PM CapsCapsuleOralNew Vision Nutritionals Company1998-10-012002-11-20Canada
PNF-FirstTablet, coatedOralAcella Pharmaceuticals, LLC2013-05-17Not applicableUs
Pnv Ferrous Fumarate Docusate Folic AcidTabletOralVirtus Pharmaceuticals2014-04-22Not applicableUs
Pnv Prenatal Plus MultivitaminTabletOralClinical Solutions Wholsesale2013-04-012017-07-03Us
Pnv Prenatal VitaminTablet, chewableOralSancilio & Company Inc.2011-12-20Not applicableUs
Pnv Prenatal Vitamin Plus Vitamin ATabletOralSancilio & Company Inc.2012-12-07Not applicableUs
Pnv-selectTablet, film coatedOralAcella Pharmaceuticals, LLC2009-11-02Not applicableUs
Poly-VI-sol DropsLiquidOralMead Johnson Nutritionals1986-12-312000-09-11Canada
Polymine Avec Zinc Et CuivreTabletOralLes Laboratoires Vachon Inc.1985-12-312007-07-12Canada
Potassium Plus Vit B ComplexTabletOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
Prefera Ob Plus DHATabletOralAlaven Pharmaceutical2009-04-01Not applicableUs
PreferaobTablet, coatedOralMeda Pharmaceuticals Ltd2015-04-28Not applicableUs
Preferaob Plus DHATabletOralAlaven Pharmaceutical2010-11-15Not applicableUs
PregvitTabletOralDuchesnay Inc.2003-08-252016-07-05Canada
Pregvit Folic 4TabletOralDuchesnay Inc.Not applicableNot applicableCanada
Pregvit Folic 5TabletOralDuchesnay Inc.2006-03-172016-07-05Canada
Prenatal 19Tablet, coatedOralNationwide Laboratories2013-06-01Not applicableUs
Prenatal Mega AntioxidantTabletOralUsana Health Services, Inc.2012-04-11Not applicableUs
Prenatal PlusTablet, film coatedOralBlenheim Pharmacal, Inc.2010-12-09Not applicableUs65162 0668 50 nlmimage10 120e0910
Prenatal Plus IronTablet, film coatedOralMajor2011-06-07Not applicableUs
Prenatal Vitamins PlusTabletOralbryant ranch prepack2011-04-15Not applicableUs
Prenatal Vitamins Plus Low IronTabletOralPatrin Pharma2013-04-01Not applicableUs39328 0106 10 nlmimage10 df476fdb
Prenate EliteTablet, coatedOralAvion Pharmaceuticals, Llc2012-08-06Not applicableUs
Prenate StarTablet, coatedOralAvion Pharmaceuticals, Llc2014-06-05Not applicableUs
PreplusTabletOralVirtus Pharmaceuticals2014-04-04Not applicableUs
Preque 10TabletOralActavis Pharma Company2011-11-01Not applicableUs
PretabTabletOralVirtus Pharmaceuticals2014-04-092017-08-08Us
Prevital TabTabletOralBio Vita1991-12-312000-07-20Canada
Purevit Dualfe PlusCapsuleOralPure Tek Corporation2011-06-01Not applicableUs
Q.T. Vitamin and Mineral Drink MixPowderOralGarden State NutritionalsNot applicableNot applicableCanada
Reaphirm Plant Source DHACapsule, gelatin coatedOralEverett Laboratories, Inc.2011-12-05Not applicableUs
Reno CapsCapsuleOralNnodum Pharmaceuticals2008-11-30Not applicableUs63044 0622 01 nlmimage10 7d3cbea5
ReplaviteTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1999-10-202002-07-31Canada
Revit Plus CapCapsuleOralIcn Pharmaceuticals1972-12-311998-08-13Canada
Revit TabTabletOralIcn Pharmaceuticals1980-12-311998-08-13Canada
Revitex Ampoules Et ComprimesLiquid; TabletOralLes Produits Gerbex Inc.1988-12-312005-06-29Canada
Revival 1 TabTabletOralBio Vita1991-12-311999-08-12Canada
Right Choice A.M. Multi Formula - CapletTabletOralBody Wise International LlcNot applicableNot applicableCanada
Se-natal 19TabletOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-natal 19 ChewableTablet, chewableOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-natal OneTabletOralSeton Pharmaceuticals2009-04-162016-10-13Us
Se-tan PlusCapsule, gelatin coatedOralSeton Pharmaceuticals2009-10-01Not applicableUs
Sibergin B - CapCapsuleOralPharmavite1996-09-031998-09-08Canada
Somarexin and C 1000Liquid; TabletOralLaboratoire Lalco Inc.1977-12-312008-07-29Canada
Somavit Brand Vitamins and Minerals ComplexTabletOralSoma Health Products2000-01-152005-08-26Canada
Sopalamine/3b Plus CTabletOralTechnilab Pharma Inc.1987-12-312001-09-05Canada
Spectrum 2 CapCapsuleOralNf Formulas Inc.1988-12-312008-06-26Canada
Stress B & C CapletTabletOralHealth Wise Nutrition Inc.1995-12-311998-08-25Canada
Stress B Capsules With Vitamin CCapsuleOralRheingold Food International Ltd.1987-12-312007-07-26Canada
Stress B Complex With C, E & IronTabletOralPharmavite1999-10-312005-07-15Canada
Stress B With 1000 Mg Vitamin CTabletOralHolista Health (Canada) Inc.2002-11-132008-07-17Canada
Stress B&c TabTabletOralBioforce Canada Inc.1985-12-311997-04-04Canada
Stress Complex 600 Avec Vit E Cuivre ZincTabletOralFrega Inc.1995-12-312008-02-13Canada
Stress Ctr SrtTablet, extended releaseOralBioenergy Inc.1979-12-311998-06-03Canada
Stress FormulaTabletOralVita Health Products Inc1998-05-202005-07-20Canada
Stress Formula + IronTabletOralVita Health Products Inc1998-05-202006-07-31Canada
Stress Formula B-comp + 500mg Vit C TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312002-07-29Canada
Stress Formula Multi-B Comp + 500mg Vit C CapCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Stress Formula Multivitamin Tablets USPTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Stress Formula TabTabletOralNatures Sunshine Products, Inc.1986-12-312009-09-09Canada
Stress Formula Vit B With C ComplexTabletOralWatkins Incorporated1985-12-312000-01-15Canada
Stress Forte Plus Lipotropic FactorsTabletOralDouglas Laboratories1995-12-312009-09-29Canada
Stress TabTabletOralVita Health Products Inc1981-12-312005-07-20Canada
Stress TabletsTabletOralD.C. Labs Limited1981-12-312003-07-11Canada
Stress Vitamin B With C Complex TabletsTabletOralPurity Life Health Products A Division Of Sunopta Inc.2002-06-012007-07-26Canada
StressmatesTabletOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Strovite Forte CapletTablet, coatedOralEverett Laboratories, Inc.1996-10-01Not applicableUs
Strovite One CapletsTabletOralEverett Laboratories, Inc.2001-05-04Not applicableUs
Sun-rype VitaburstLiquidOralSun Rype Products Ltd.2004-08-102008-03-13Canada
Super B Compound W 500mg Vit CTabletOralGahler Enterprises Ltd.1986-12-312000-08-01Canada
Super Charged EnergyPowderOralSimone Protective Pharmaceuticals, Inc.Not applicableNot applicableCanada
Super Daily No 2TabletOralW.R. Enterprises Inc.1990-12-312003-07-30Canada
Super PantoplexTabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Super Stress CapsulesCapsuleOralRheingold Food International Ltd.1987-12-311997-08-22Canada
Super Stress Mega B Plus 1000mg Vit C TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Super Vitalex Ampoule BuvableLiquidOralCarmaran LtÉe1984-12-312001-08-31Canada
Super-pote Vitamin SupplementTabletOralGarden State Nutritionals1998-09-252000-06-07Canada
Supplement De Multivitamines Infusion Arome Fruits RougesKitOralYves Rocher Inc.1999-10-182000-08-08Canada
Supravite 10ml AmpouleLiquidOralNobel Pharm Enr.1991-12-312002-09-06Canada
Supravite Bouteille 250mlLiquidOralNobel Pharm Enr.2002-10-312008-07-29Canada
Supravite C 1000Liquid; TabletOralNobel Pharm Enr.1981-12-312002-09-06Canada
Supravite Pour EnfantsTabletOralPharmalab Inc.1985-12-312008-07-14Canada
Supravite Stress Avec Vit ETabletOralPharmalab Inc.1985-12-311997-08-08Canada
Supravite Stress Avec Vit E Cuivre Et ZincTabletOralPharmalab Inc.1985-12-311997-08-08Canada
Supravite Stress Avec Vit E Et FerTabletOralPharmalab Inc.1985-12-311997-08-08Canada
Surbex 500 FilmtabTabletOralAbbott1979-12-312008-06-06Canada
Surbex-500 With IronTabletOralAbbott1986-12-312008-06-06Canada
Surbex-500 With ZincTabletOralAbbott1986-12-312008-06-06Canada
Swical-energy-2LiquidOralLes Laboratoires Swisse Inc.1997-06-092006-02-14Canada
T.R.I. B-plex SrcCapsule, extended releaseOralAnabolic Laboratories Inc.1979-12-312004-03-15Canada
Tandem ObCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tandem PlusCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tender Age Multi VitaminsLiquidOralJamieson Laboratories Ltd1982-12-312000-09-08Canada
Time Release B 100 Compound - TabletTabletOralHealth Wise Nutrition Inc.1996-10-222002-07-18Canada
Timed Release B Complex 100 SrtTablet, extended releaseOralJamieson Laboratories Ltd1994-12-311997-08-13Canada
Timed Release B-complex 100Tablet, extended releaseOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Timed Release B-complex 50Tablet, extended releaseOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Tini-cal AmpoulesLiquidOralPharmetics (2011) Inc.1966-12-312001-07-26Canada
Toni Com LiqLiquidOralVitalab1990-12-312009-07-14Canada
Tonicol Et A-D-C Ampoules/comprimesLiquid; TabletOralDistributions Multi Pro Inc.1988-12-311999-07-21Canada
Tonimol Cap LiqCapsule; LiquidOralHerbes Universelles Inc.1978-12-312009-07-15Canada
TriadvanceTabletOralTrigen Laboratories, Inc.2010-09-10Not applicableUs
Tricare PrenatalTablet, coatedOralMedecor Pharma, Llc2002-11-11Not applicableUs
Trinatal GtTabletOralTrigen Laboratories, Inc.2011-07-05Not applicableUs
Twin Ultra Liquid Fruit Punch FlavorLiquidOralTwin Laboratories Inc.1995-12-312002-09-11Canada
Twin Ultra Liquid Grape FlavorLiquidOralTwin Laboratories Inc.1995-12-312007-08-01Canada
Twin Ultra Liquid Lemon-lime FlavorLiquidOralTwin Laboratories Inc.1995-12-312005-08-30Canada
Twin Ultra Liquid Orange FlavorLiquidOralTwin Laboratories Inc.1995-12-312002-09-11Canada
Ultimatecare One NfCapsuleOralTrigen Laboratories, Inc.2009-12-04Not applicableUs
Ultra EnerforceLiquidOralNutribon (1986) Inc.2002-01-292005-02-16Canada
Ultra HrTabletOralNatural Organics Inc.Not applicableNot applicableCanada
Usana Megavitamin Tablets - TabTabletOralUsana Health Sciences, Inc.1996-12-302000-09-11Canada
Vasodyn TabTabletOralNutri Dyn Products Ltd.1978-12-311998-08-13Canada
Viamon Ampoules Et ComprimesLiquid; TabletOralLab Nadeau LtÉe, Division Of Technilab Inc.1977-12-311999-09-28Canada
Vigo Multivitamins Drops/lozengeLozengeOralAshbury Research CorporationNot applicableNot applicableCanada
Vimeral TabTabletOralIcn Pharmaceuticals1979-12-312005-04-26Canada
Virt-capsCapsule, gelatin coatedOralVirtus Pharmaceuticals2014-04-012017-08-11Us
Virt-PNTablet, coatedOralVirtus Pharmaceuticals2012-07-122017-08-09Us
Virt-vite PlusTabletOralVirtus Pharmaceuticals2014-01-142017-08-11Us
Vit B Complex CtrTablet, extended releaseOralBioenergy Inc.1979-12-311998-06-03Canada
Vit B Complex Plus Vit C 550mgCapsuleOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Vit-HA Multi Vitamin and Zinc SupplementTabletOralRheingold Food International Ltd.1994-12-312007-07-26Canada
Vita B + C 500 TabTabletOralLaboratoire Romilo1993-12-311999-08-18Canada
Vita B Complex TabTabletOralNutrimetics International (Canada) Inc.1985-12-312000-07-19Canada
Vita Day TabTabletOralJamieson Laboratories Ltd1993-12-311997-08-13Canada
Vita-BTabletOralNutri Dyn Products Ltd.1984-12-311997-08-22Canada
Vita-B-75 CapCapsuleOralLes Laboratoires Vachon Inc.1989-12-311998-09-28Canada
Vita-worth B-complex TabletsTabletOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
Vitabanks Vitamin TabTabletOralVitabank Inc.1990-12-311997-05-30Canada
Vitachrom GcTabletOralNikken Usa, Incorporated2000-08-302007-10-01Canada
Vitaday TabTabletOralPharmetics (2011) Inc.1977-12-311999-08-13Canada
VitafantTabletOralLes Laboratoires Vachon Inc.1994-12-312008-07-09Canada
Vitafer - LiqLiquidOralFrega Inc.1995-12-311997-12-10Canada
Vitaflex Dietary SuplementTabletOralHome Shopping Network DirectNot applicableNot applicableCanada
Vitafol CapletCapsuleOralEverett Laboratories, Inc.1985-05-01Not applicableUs
Vitafol Ob CapletTabletOralExeltis Usa, Inc.2002-12-02Not applicableUs
Vitafol OneCapsule, gelatin coatedOralEverett Laboratories, Inc.2011-06-13Not applicableUs
Vitafol PlusCapsule, liquid filledOralEverett Laboratories, Inc.2012-04-23Not applicableUs
Vitafol UltraCapsule, liquid filledOralExeltis Usa, Inc.2013-09-23Not applicableUs
Vitalife - CapsuleCapsuleOralHolista Health (Canada) Inc.1996-11-132002-08-06Canada
Vitamin and Mineral Supplement - LiqLiquidOralTechnilab Pharma Inc.1998-05-252005-08-05Canada
Vitamin B + C CapCapsuleOralFinlandia Consultants1990-12-311997-12-02Canada
Vitamin B ComplexInjectionIntravenousMylan Institutional2013-05-10Not applicableUs
Vitamin B Complex + C 300mg CapCapsuleOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Vitamin B Complex + C 600mg TabTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Vitamin B Complex 100 TabTabletOralBioforce Canada Inc.1994-12-311997-04-04Canada
Vitamin B Complex 50TabletOralGfr Pharma Ltd.2002-10-102004-06-15Canada
Vitamin B Complex Plus 300mg Vitamin CTabletOralHall Laboratories, Ltd.1996-11-282003-09-11Canada
Vitamin B Complex Plus C 300mg Timed ReleaseTablet, extended releaseOralVita Health Products Inc1998-10-062009-08-06Canada
Vitamin B Complex SupplTabletOralAvacare, Division Of Jeunique International Inc.1985-12-312006-07-20Canada
Vitamin B Complex TabTabletOralNutristar Health Products (1987) Inc.1981-12-311996-09-09Canada
Vitamin B Complex W C 300mg TabTabletOralLee Adams Laboratories1982-12-312009-12-02Canada
Vitamin B Complex W C TabTabletOralAlbi Imports Ltd.1979-12-312004-09-24Canada
Vitamin B Compound TabTabletOralNutrilite, A Division Of Access Business Group, Llc1982-12-311996-09-09Canada
Vitamin B Compound W C Tab 500mgTabletOralAdams Laboratories1979-12-312009-10-21Canada
Vitamin B Compound W Vit C 250mg TabTabletOralSwiss Herbal Remedies Ltd.1972-12-312003-09-10Canada
Vitamin B Compound With Vitamin C Fortis Capsule DtcCapsuleOralD.C. Labs Limited1973-12-312005-07-19Canada
Vitamin B Cpd W Vit C TabTabletOralIcn Pharmaceuticals1978-12-312005-04-26Canada
Vitamin B TabletsTabletOralWeider Health Products1985-12-311999-09-09Canada
Vitamine 110 LiqLiquidOralFrega Inc.1993-12-312008-07-09Canada
Vitamine Du Groupe B Plus Fer - LiqLiquidOralPharmalab Inc.1995-12-312008-07-14Canada
Vitamines Pour Bebes Et EnfantsLiquidOralHerbes Universelles Inc.1978-12-312009-07-15Canada
Vitogen B Compound W C Fortis CapsulesCapsuleOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1972-12-311997-10-14Canada
Vitogen B Stress C Vit E Zinc & CopTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1984-12-312002-07-31Canada
Vitogen B Stress C600TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1981-12-312002-07-31Canada
Vitogen Multiple Vitamins TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1966-12-311997-10-14Canada
Vitogen Multiple Vitamins W IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1976-12-311997-10-14Canada
Vitreat Chewable Vitamin TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1972-12-311997-08-08Canada
Vitreat Chewable Vitamins Plus IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1977-12-311997-08-08Canada
VP-heme OBTablet, film coatedOralVirtus Pharmaceuticals2013-10-14Not applicableUs
Vtb Vitamin and Mineral SupplementTabletOralGarden State NutritionalsNot applicableNot applicableCanada
Women's FormulaTabletOralPro Ma Systems1998-10-312007-09-25Canada
Zoo ChewsTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Categories
UNIITLM2976OFR
CAS number83-88-5
WeightAverage: 376.3639
Monoisotopic: 376.138284392
Chemical FormulaC17H20N4O6
InChI KeyAUNGANRZJHBGPY-SCRDCRAPSA-N
InChI
InChI=1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1
IUPAC Name
7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]-2H,3H,4H,10H-benzo[g]pteridine-2,4-dione
SMILES
CC1=C(C)C=C2N(C[[email protected]](O)[[email protected]](O)[[email protected]](O)CO)C3=NC(=O)NC(=O)C3=NC2=C1
Pharmacology
Indication

For the treatment of ariboflavinosis (vitamin B2 deficiency).

Structured Indications
Pharmacodynamics

Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolising of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. Riboflavin also helps in the prevention or treatment of many types of eye disorders, including some cases of cataracts.

Mechanism of action

Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.

TargetKindPharmacological actionActionsOrganismUniProt ID
Riboflavin kinaseProteinyes
ligand
HumanQ969G6 details
Riboflavin synthaseProteinyes
other
Escherichia coli (strain K12)P0AFU8 details
Flavin reductase (NADPH)Proteinyes
product of
HumanP30043 details
Related Articles
Absorption

Vitamin B2 is readily absorbed from the upper gastrointestinal tract.

Volume of distributionNot Available
Protein binding

60%

Metabolism

Hepatic.

Route of eliminationNot Available
Half life

66-84 minutes

ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Riboflavin MetabolismMetabolicSMP00070
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
Porfimer sodiumRiboflavin may increase the photosensitizing activities of Porfimer.Approved, Investigational
VerteporfinRiboflavin may increase the photosensitizing activities of Verteporfin.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

Hansgeorg Ernst, Wolfram Schmidt, Joachim Paust, "Preparation of riboflavin." U.S. Patent US4567261, issued August, 1958.

US4567261
General References
  1. Zempleni J, Galloway JR, McCormick DB: Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr. 1996 Jan;63(1):54-66. [PubMed:8604671 ]
External Links
ATC CodesA11HA04 — Riboflavin (vit b2)
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSDownload (39.4 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections / Infection, Human Immunodeficiency Virus I / Mycobacterium avium complex infection1
1CompletedDiagnosticHealthy Volunteers1
1CompletedPreventionHIV/AIDS1
1CompletedTreatmentCancers / Metastases1
1CompletedTreatmentUlcerative keratitis1
1Not Yet RecruitingBasic ScienceAging / Mineral deficiency / Vitamin Deficiency1
1, 2RecruitingOtherHypercholesterolemia, Familial / Hypertriglyceridemias1
1, 2RecruitingPreventionKeratolysis1
1, 2RecruitingTreatmentAutoimmune Diseases / Chemical Injuries / Lupus Erythematosus, Systemic / Ocular Cicatricial Pemphigoid / Other Autoimmune Diseases / Rheumatoid Arthritis / Stevens Johnson Syndrome / Unspecified Complication of Corneal Transplant1
1, 2SuspendedTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
2Active Not RecruitingTreatmentKeratoconus1
2Active Not RecruitingTreatmentKeratoconus / Post-Refractive Ectasia1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentCancer, Breast1
2CompletedTreatmentCentral Serous Chorioretinopathy (CSC)1
2Not Yet RecruitingBasic ScienceAlcohol Drinking1
2Not Yet RecruitingTreatmentSports-related Concussion1
2RecruitingPreventionAmnestic / Cognitive Disorders / Delayed Emergence From Anesthesia / Delirium / Delirium, Dementia / Delirium, Dementia, Amnestic, Cognitive Disorders1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2RecruitingTreatmentPsoriasis1
2Unknown StatusTreatmentCorneal Ectasia / Ectasia / Keratoconus1
2Unknown StatusTreatmentMyocardial Infarction (MI)1
2WithdrawnOtherCompliance / Pain, Chronic1
2, 3CompletedTreatmentAcidosis, Respiratory1
2, 3CompletedTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Mortality1
2, 3Unknown StatusTreatmentEctasia / Keratoconus1
2, 3WithdrawnTreatmentCorneal Ectasia / Progressive Keratoconus1
3Active Not RecruitingTreatmentCorneal Ectasia / Keratoconus3
3Active Not RecruitingTreatmentKeratoconus1
3CompletedPreventionComplications, Pregnancy / Human Immunodeficiency Virus (HIV) Infections1
3CompletedPreventionCoronary Artery Bypass Grafting (CABG) Surgery / Left Ventricular Dysfonction1
3CompletedTreatmentAnemias1
3CompletedTreatmentDiarrheal Illnesses / Growth Faltering / Respiratory Illness1
3CompletedTreatmentEctasia1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis, Pulmonary1
3CompletedTreatmentHydatidiform Mole1
3CompletedTreatmentKeratoconus2
3CompletedTreatmentProgressive Keratoconus1
3RecruitingTreatmentCrohn's Disease (CD) / Oral Ulcers1
3RecruitingTreatmentKeratoconus1
3TerminatedNot AvailableKeratoconus and Ectasia1
3TerminatedTreatmentCorneal Ectasia / Keratoconus1
3TerminatedTreatmentEctasia1
3TerminatedTreatmentKeratoconus2
3TerminatedTreatmentMultiple System Atrophy (MSA)1
3Unknown StatusNot AvailableAnemias / Low Birth Weight / Neonatal Mortality1
3Unknown StatusTreatmentAlzheimer's Disease (AD) / Down Syndrome (DS)1
3Unknown StatusTreatmentUnstable Corneas1
4CompletedHealth Services ResearchAcidosis, Respiratory / Aids / Human Immunodeficiency Virus (HIV) Infections / Lipodystrophies1
4CompletedTreatmentDiabetic Peripheral Neuropathic Pain1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentPregnancy1
4CompletedTreatmentProgressive Keratoconus / Thin Corneas1
4CompletedTreatmentSmoking Addiction1
4RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4WithdrawnTreatmentNephritis / Proteinuria / Systemic Lupus Erythematosus (SLE)1
Not AvailableCompletedNot AvailableFruste Keratoconus / Risk of Ectasia1
Not AvailableCompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedPreventionNeural Tube Defects (NTDs)1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections2
Not AvailableNot Yet RecruitingTreatmentBreast Cancer Metastatic / Metastatic Breast Cancer (MBC)1
Not AvailableRecruitingTreatmentEctasia / Keratoconus1
Not AvailableRecruitingTreatmentTemporomandibular Joint Disorders1
Not AvailableTerminatedTreatmentInfectious Keratitis1
Not AvailableUnknown StatusPreventionBrittle Cornea Syndrome / Ehlers-Danlos Syndrome Type 61
Not AvailableUnknown StatusTreatmentSports Related Concussion1
Not AvailableWithdrawnPreventionHuman Immunodeficiency Virus (HIV) Infections1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
ElixirOral
Tablet, extended releaseOral
InjectionIntramuscular
Injection, solutionIntramuscular; Intravenous
Powder, for solutionIntramuscular; Intravenous
Powder, for solutionIntravenous
GranuleOral
TabletOral
Tablet, effervescentOral
SyrupOral
LiquidIntramuscular; Intravenous
Kit
PowderOral
Tablet, chewableOral
LiquidIntravenous
Injection, powder, lyophilized, for solutionIntravenous
Liquid; tabletOral
Solution / dropsOral
SolutionIntravenous
Granule, effervescentOral
LiquidOral
SolutionOral
SolutionIntramuscular; Intravenous
Injection, solutionIntravenous
Solution / dropsOphthalmic1.46 mg/mL
Tablet, coatedOral
CapsuleOral50 mg
SolutionIntramuscular; Intravenous50 mg
TabletOral10 mg
TabletOral5 mg
TabletOral25 mg
KitOral
Capsule, extended releaseOral
Capsule; liquidOral
LozengeOral
Tablet, extended releaseOral200 mg
CapsuleOral100 mg
CapsuleOral
Capsule, gelatin coatedOral
Capsule, liquid filledOral
InjectionIntramuscular; Intravenous
InjectionIntravenous
TabletOral50 mg
TabletOral100 mg
TabletOral4 mg
Tablet, film coatedOral
Prices
Unit descriptionCostUnit
Riboflavin powder0.44USD g
Riboflavin 100 mg tablet0.09USD tablet
Riboflavin 50 mg tablet0.08USD tablet
Vitamin b-2 50 mg tablet0.08USD tablet
Ribo 100 mg tablet0.04USD tablet
Vitamin b-2 25 mg tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)280 dec °CPhysProp
water solubility84.7 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-1.46HANSCH,C ET AL. (1995)
logS-3.68ADME Research, USCD
pKa10.2BUDAVARI,S ET AL. (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.657 mg/mLALOGPS
logP-1.1ALOGPS
logP-0.92ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)6.97ChemAxon
pKa (Strongest Basic)0.76ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area155.05 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity96.27 m3·mol-1ChemAxon
Polarizability37.5 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9156
Blood Brain Barrier-0.8495
Caco-2 permeable-0.7122
P-glycoprotein substrateSubstrate0.7414
P-glycoprotein inhibitor INon-inhibitor0.8708
P-glycoprotein inhibitor IINon-inhibitor0.9466
Renal organic cation transporterNon-inhibitor0.9279
CYP450 2C9 substrateNon-substrate0.7819
CYP450 2D6 substrateNon-substrate0.8435
CYP450 3A4 substrateNon-substrate0.522
CYP450 1A2 substrateInhibitor0.8531
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9516
CYP450 2C19 inhibitorInhibitor0.7302
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9203
Ames testNon AMES toxic0.804
CarcinogenicityNon-carcinogens0.7954
BiodegradationNot ready biodegradable0.9641
Rat acute toxicity1.6067 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9395
hERG inhibition (predictor II)Non-inhibitor0.5362
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Download (11.3 KB)
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-004i-0019000000-86365dedafa031aa7787View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0006-4390000000-ac1b59ab7cc2209f4241View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-00dj-4900000000-72d33eb27b9bd6a13d9eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-004l-0569000000-874b71fdc78d04853bf0View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0a4i-0091000000-a82c54d3153103fcdb1fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , negativesplash10-0a4i-0090000000-2aff124ee1fc62c13844View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , negativesplash10-0a4i-0090000000-f8b29c3e2c601a944a6cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , negativesplash10-0a4i-0090000000-4e8c9bd38ea0f5ae9a94View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-0006-0092000000-1f1be5508c1d50d8dff7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-0006-0092000000-74bf0b86efe72fe37198View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-057i-0069000000-bb0522be4472e049dbc5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-057i-0069000000-208440cf501d0b9050d7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-006x-0029000000-8c3d72bf2a06d79bbd31View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-006x-0039000000-7d8dc991995cfc262ad1View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-0006-0092000000-4f524f1e6c8131751c92View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-0560-0069000000-edc332be3fcbf6d0c14bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-0006-0009000000-2e6bf027d624900baabdView in MoNA
LC-MS/MSLC-MS/MS Spectrum - , positivesplash10-004i-0239000000-659ca9fae9643f3ce73dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-qTof , PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as flavins. These are compounds containing a flavin (7,8-dimethyl-benzo[g]pteridine-2,4-dione) moiety, with a structure characterized by an isoalloaxzine tricyclic ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPteridines and derivatives
Sub ClassAlloxazines and isoalloxazines
Direct ParentFlavins
Alternative ParentsQuinoxalines / Pyrimidones / Pyrazines / Benzenoids / Vinylogous amides / Heteroaromatic compounds / Secondary alcohols / Lactams / Polyols / Azacyclic compounds
SubstituentsFlavin / Diazanaphthalene / Quinoxaline / Pyrimidone / Pyrazine / Pyrimidine / Benzenoid / Heteroaromatic compound / Vinylogous amide / Secondary alcohol
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptorsflavin (CHEBI:17015 ) / Water-soluble vitamins (C00255 )

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
ligand
General Function:
Riboflavin kinase activity
Specific Function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH...
Gene Name:
RFK
Uniprot ID:
Q969G6
Uniprot Name:
Riboflavin kinase
Molecular Weight:
17623.08 Da
References
  1. Werner R, Manthey KC, Griffin JB, Zempleni J: HepG2 cells develop signs of riboflavin deficiency within 4 days of culture in riboflavin-deficient medium. J Nutr Biochem. 2005 Oct;16(10):617-24. [PubMed:16081269 ]
  2. Solovieva IM, Kreneva RA, Errais Lopes L, Perumov DA: The riboflavin kinase encoding gene ribR of Bacillus subtilis is a part of a 10 kb operon, which is negatively regulated by the yrzC gene product. FEMS Microbiol Lett. 2005 Feb 1;243(1):51-8. [PubMed:15668000 ]
  3. Ishchuk OP, Iatsyshyn VIu, Dmytruk KV, Voronovs'kyi AIa, Fedorovych DV, Sybirnyi AA: [Construction of the flavinogenic yeast Candida famata strains with high riboflavin kinase activity using gene engineering]. Ukr Biokhim Zh (1999). 2006 Sep-Oct;78(5):63-9. [PubMed:17290783 ]
  4. Sandoval FJ, Roje S: An FMN hydrolase is fused to a riboflavin kinase homolog in plants. J Biol Chem. 2005 Nov 18;280(46):38337-45. Epub 2005 Sep 23. [PubMed:16183635 ]
  5. Bertollo CM, Oliveira AC, Rocha LT, Costa KA, Nascimento EB Jr, Coelho MM: Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models. Eur J Pharmacol. 2006 Oct 10;547(1-3):184-91. Epub 2006 Jul 26. [PubMed:16962092 ]
  6. Hirano G, Izumi H, Yasuniwa Y, Shimajiri S, Ke-Yong W, Sasagiri Y, Kusaba H, Matsumoto K, Hasegawa T, Akimoto M, Akashi K, Kohno K: Involvement of riboflavin kinase expression in cellular sensitivity against cisplatin. Int J Oncol. 2011 Apr;38(4):893-902. doi: 10.3892/ijo.2011.938. Epub 2011 Feb 9. [PubMed:21308351 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
other
General Function:
Riboflavin synthase activity
Specific Function:
Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
Gene Name:
ribC
Uniprot ID:
P0AFU8
Uniprot Name:
Riboflavin synthase
Molecular Weight:
23444.77 Da
References
  1. Kim RR, Illarionov B, Joshi M, Cushman M, Lee CY, Eisenreich W, Fischer M, Bacher A: Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion. J Am Chem Soc. 2010 Mar 10;132(9):2983-90. doi: 10.1021/ja908395r. [PubMed:20143812 ]
  2. Long Q, Ji L, Wang H, Xie J: Riboflavin biosynthetic and regulatory factors as potential novel anti-infective drug targets. Chem Biol Drug Des. 2010 Apr;75(4):339-47. doi: 10.1111/j.1747-0285.2010.00946.x. Epub 2010 Feb 8. [PubMed:20148904 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
product of
General Function:
Riboflavin reductase (nadph) activity
Specific Function:
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
Gene Name:
BLVRB
Uniprot ID:
P30043
Uniprot Name:
Flavin reductase (NADPH)
Molecular Weight:
22119.215 Da
References
  1. Russell TR, Demeler B, Tu SC: Kinetic mechanism and quaternary structure of Aminobacter aminovorans NADH:flavin oxidoreductase: an unusual flavin reductase with bound flavin. Biochemistry. 2004 Feb 17;43(6):1580-90. [PubMed:14769034 ]
  2. van Pee KH, Patallo EP: Flavin-dependent halogenases involved in secondary metabolism in bacteria. Appl Microbiol Biotechnol. 2006 May;70(6):631-41. Epub 2006 Mar 17. [PubMed:16544142 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Serotonin binding
Specific Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Gene Name:
MAOA
Uniprot ID:
P21397
Uniprot Name:
Amine oxidase [flavin-containing] A
Molecular Weight:
59681.27 Da
References
  1. Strolin Benedetti M, Tipton KF, Whomsley R: Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected? Fundam Clin Pharmacol. 2007 Oct;21(5):467-80. [PubMed:17868200 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Protein complex binding
Specific Function:
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
Gene Name:
MTHFR
Uniprot ID:
P42898
Uniprot Name:
Methylenetetrahydrofolate reductase
Molecular Weight:
74595.895 Da
References
  1. Bates CJ, Fuller NJ: The effect of riboflavin deficiency on methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.20) and folate metabolism in the rat. Br J Nutr. 1986 Mar;55(2):455-64. [PubMed:3676170 ]
  2. Macdonald HM, McGuigan FE, Fraser WD, New SA, Ralston SH, Reid DM: Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density. Bone. 2004 Oct;35(4):957-64. [PubMed:15454103 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Uniprot Name:
Solute carrier family 22 member 6
Molecular Weight:
61815.78 Da
References
  1. Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. [PubMed:9880528 ]
Drug created on June 13, 2005 07:24 / Updated on August 02, 2017 16:20