Accession NumberDB00140  (NUTR00010, APRD00626, EXPT02760, DB09358)
TypeSmall Molecule
GroupsApproved, Nutraceutical, Vet Approved

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]

Vitamin B2
Vitamin G
External IDs INS NO. 101(I) / NCI-0033298 / NSC-33298
Product Ingredients
IngredientUNIICASInChI KeyDetails
Riboflavin 5'-phosphate sodium20RD1DZH99 6184-17-4LQVGUKOCMOKKJU-QPVGXXQTSA-MDetails
Riboflavin 5'-phosphate sodium anhydrous957E53WV42 130-40-5OHSHFZJLPYLRIP-BMZHGHOISA-MDetails
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
PhotrexaSolution / drops1.46 mg/mLOphthalmicAvedro, Inc.2016-04-15Not applicableUs
Photrexa ViscousSolution / drops1.46 mg/mLOphthalmicAvedro, Inc.2016-04-15Not applicableUs
Riboflavin Inj 50mg/mlSolution50 mgIntramuscular; IntravenousKripps Pharmacy Ltd.1979-12-31Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
B-2 Caps 100mgCapsule100 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
B2 Tab 100mgTablet100 mgOralVita Health Products Inc1979-12-312002-07-31Canada
Riboflavin 5 Phosphate Cap 50mgCapsule50 mgOralThorne Research Inc.1985-12-312001-07-13Canada
Riboflavin Tab 10mgTablet10 mgOralSwiss Herbal Remedies Ltd.1971-12-311999-09-09Canada
Riboflavin Tab 5mgTablet5 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Riboflavin-S Tab 25mgTablet25 mgOralNutri West Products Ltd.1993-12-311997-08-05Canada
Vit B2 Ctr Srt 200mgTablet, extended release200 mgOralBioenergy Inc.1979-12-311998-06-03Canada
Vita-flavine Cap 100mgCapsule100 mgOralLes Laboratoires Vachon Inc.1991-12-312001-08-07Canada
Vitamin B-2Capsule100 mgOralSisu Inc.2001-09-012006-07-31Canada
Vitamin B-2 50 Mg TabletsTablet50 mgOralGeneral Nutrition Canada Inc.1997-04-182006-08-03Canada
Vitamin B-2 Riboflavin 100mg CapsulesCapsule100 mgOralAlbi Naturals1999-04-302009-07-15Canada
Vitamin B2 100 mgCapsule100 mgOralFlora Manufacturing And Distributing Ltd.2002-03-152004-08-04Canada
Vitamin B2 100mgTablet100 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Vitamin B2 Tab 100mgTablet100 mgOralQuest Vitamins A Div Of Purity Life Health Products1978-12-312001-07-06Canada
Vitamin B2 Tab 4mg USP ChewableTablet4 mgOralLab Gernetic Int Ltee1985-12-311997-02-21Canada
Vitamin B2 Tablets 100mgTablet100 mgOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
Unapproved/Other Products Not Available
International Brands
BisulaseNot Available
Brand mixtures
Active FeGm Pharmaceuticals
Adult Infuvite Multiple VitaminsSandoz
AlertonicOdan Laboratories Ltd
Allbee With C 550 CapWhitehall Robins Inc.
Allbee With Vitamin C CapWhitehall Robins Inc.
Alsimine W Vitamins A DAlsi Cie Ltee
Am CapsNew Vision Nutritionals Company
AntlervironClassical Remedia Ltd
AppedrineChattem, Inc.
B 50 CapsulesRheingold Food International Ltd.
B 6 PlusAnabolic Laboratories Inc.
B C Antistress CapLes Laboratoires Bio SantÉ Inc.
B Complex 25mg Vitamin SupplementGarden State Nutritionals
B Complex 50 Vitamin CapBioforce Canada Inc.
B Complex 50+ CapletHealth Wise Nutrition Inc.
B Complex 500 TabNobel Pharm Enr.
B Complex Plus C 300mg TabNutricorp International
B Complex TabletsGolden Neo Life Diamite International, Limited
B Complex W C and B12 InjE L Stickley And Co Ltd.
B Complex W C Forte CapEverest Pharmaceuticals Ltd.
B Complex W Vit C W Non-med Yeast&liver TabPharmavite
B Complex W Vitamin C Fortis CapShoppers Drug Mart Inc.
B Complex With C 300mgVita Health Products Inc
B Complex With C 300mg TabPharmavite
B Complex With C 550mgVita Health Products Inc
B Compound 50mg TabGahler Enterprises Ltd.
B Plus C 300mg Timed ReleaseVita Health Products Inc
B Stress C + Iron & ViteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
B Totum 500Desbergers LtÉe, Division Of Technilab Inc.
B VirolRolmex International Inc.
B Vitamin Compound With B12 ThunasThuna Herbal Remedies Ltd.
B With C 500 CapPharmetics (2011) Inc.
B-100 CapsNow Foods
B-100 Complex TabletsViva Pharmaceutical Inc.
B-100 Hi Potency B Vitamins TabNatrol, Inc.
B-100 Vitamin SupplementGarden State Nutritionals
B-2 100mg With C 20mgGahler Enterprises Ltd.
B-50 ComplexVita Health Products Inc
B-50 Complex TabVita Health Products Inc
B-50 Hi Potency B Vitamins TabNatrol, Inc.
B-comboPerdido Key Health And Wellness Inc
B-complexEnrich International
B-complex 100Great Earth Companies, Inc.
B-complex 50Great Earth Companies, Inc.
B-complex TabNatures Sunshine Products, Inc.
B-complex TabletsShaklee Corporation
B-complex With Vitamin C, Biotin, Folic AcidWn Pharmaceuticals Ltd.
B-complex-50 TabJr Carlson Labs Inc
B-plexWn Pharmaceuticals Ltd.
B-plex 100Merit Pharmaceuticals
B-plus - TabChampion's Choice Advanced Nutrition Inc.
B50 B Complex TabNutristar Health Products (1987) Inc.
B50 ComplexPreferred Nutrition Inc.
B6 Plus TabVita Health Products Inc
BacminMarnel Pharmaceuticals, Llc
Balanced B 125 SrtAnabolic Laboratories Inc.
Balanced B-100 B-complex Vitamins TabPharmavite
Balanced B-100 Timed ReleasePharmavite
Balanced B-50 B-complex Vitamins TabPharmavite
Balanced B-50 B-complex Vitamins, Timed RelePharmavite
Balanced B-50 ComplexLeiner Health Products
Balanced B-complex Vit + Vit C&e TabPharmavite
Balanced B100Hall Laboratories, Ltd.
Balanced B50 ComplexHall Laboratories, Ltd.
Beminal W C Fortis InjAyerst Laboratories
Beminal With C Fortis CapWyeth Ayerst Canada Inc.
Beminal With C Fortis PwsWyeth Ayerst Canada Inc.
Bev 29 TabBeverly International Nutrition
Bev B-150Beverly International Nutrition
Bio-fenLisa & Gerry Freundl
Biovim TabLe Naturiste J.M.B. Inc.
BiovitaIldong Pharmaceutical Co., Ltd.
Bugs Bunny and Friends Multiple VitaminsBayer Inc Consumer Care
Bugs Bunny Chew Multi Vit Plus IronMiles Inc. Pharmaceutical Division
C-B ComplexAvacare, Division Of Jeunique International Inc.
C-nate DHACenturion Labs
C.A.G. TabNutrition For Life International
C.R.T. X Multivitamin & Mineral Powder MixMetaform Ltd.
Carbassist TabletsWyeth Ltd.
Cc IIAdded Dimensions
Cda-21 Vitamins With Non-medicinal Probiotic ComplexRx Vitamins Inc.
Cedevita Plus Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cedevita Sugar-free Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Central-vite 18 EssentialVita Health Products Inc
Century CompleteVita Health Products Inc
Chela Potassium PlusNu Life Nutrition Ltd.
Chela-chromium 200Nu Life Nutrition Ltd.
Chew.multiple Vits.with Extra C for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vit Plus Iron for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Extra CRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Iron TabRandle Pharmaceutical Inc.
Chewable Multiple Vitamins TabRandle Pharmaceutical Inc.
Chewable MultivitaminsWn Pharmaceuticals Ltd.
Chewable Multivitamins Plus IronWn Pharmaceuticals Ltd.
Children Choice Multivit Chewable TabSwiss Herbal Remedies Ltd.
Children Choice Multivitamin W Iron Chew TabSwiss Herbal Remedies Ltd.
Children's Chewable Multi Vit W IronShoppers Drug Mart Inc.
Children's Chewable Multi VitaminsShoppers Drug Mart Inc.
Children's Chewable Multi Vitamins With Iron TabletsVita Health Products Inc
Children's Chewable Multi-vitaminWn Pharmaceuticals Ltd.
Children's Chewable Multi-vitamin Complete With MineralsWn Pharmaceuticals Ltd.
Children's Chewable Multiple IronStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins - TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins (chewable Tablets)Pharmetics (2011) Inc.
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)Pharmetics (2011) Inc.
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)Pharmetics (2011) Inc.
Children's Vitamins ChewableVita Health Products Inc
Children's Vitamins W Iron ChewableVita Health Products Inc
Childrens Chew Multi Vitamin TabNutristar Health Products (1987) Inc.
Childrens Chewable Multiple VitaminsKsl Pharmaceuticals
Childrens Chewable Multiple Vitamins Plus FeKsl Pharmaceuticals
Childrens Chewable Multiple Vitamins TabPharmavite
Childrens Chewable MultivitaminsRandle Pharmaceutical Inc.
Childrens Chewable Multivitamins W IronRandle Pharmaceutical Inc.
Childrens Chewable Vitamin TabPharmetics (2011) Inc.
Childrens Chewable VitaminsD.C. Labs Limited
Childrens Multiple Vit and Min Chew TabCountry Health Laboratories Ltd.
Citranatal DHAMission Pharmacal
Citranatal RxMission Pharmacal
Coenzyme Q10 Isotonix Vitamin and Mineral SupplementMarket America
Complete Mega BGahler Enterprises Ltd.
Complete Multivitamins and Minerals for ChildrenQuest Vitamins A Div Of Purity Life Health Products
Complete Multivitamins and Minerals Tablets Timed ReleasePharmetics (2011) Inc.
Complex 5 - PwrAst Research
Complex-75Frega Inc.
Complexe B 75mgPharmalab Inc.
Complexe B Compose 75Les Laboratoires Bio SantÉ Inc.
Complexe B-75Frega Inc.
Concept DHAUs Pharmaceutical Corporation
Concept ObUs Pharmaceutical Corporation
Croq-vit Pour EnfantsNutrivac Ltee
D'pantothenic Acid-B1-B2 TabHealth Thru Herbs Inc.
Daily Energy Brand B-complexEnzymatic Therapy, Inc.
Derma-forcePrairie Naturals
Dexatrim TabletsChattem, Inc.
Dia-viteR & D Laboratories Inc.
DiaplexNephro Tech, Inc.
Dynam Ampoule Et TabletCardinaux Enrg Les Produits Naturels
E & I FormulaeEnrich International
E.S.T. ComplexAbundance Marketing Ltd.
Efferlife Multivitamins and MineralsNaturale Science Inc.
Enviroflex - TabEnviro Tech International Canada
EscaviteGm Pharmaceuticals
Essential B TabletsGeneral Nutrition Canada Inc.
Everyday Multiple VitaminsD.C. Labs Limited
Everyday Multiple Vitamins With IronD.C. Labs Limited
Extra P.N. Vitamin-mineral Drink MixChanges International
Ez-flexMetagenics, Inc.
Feminique W Iron and Calcium TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Ferra Naka Plus VitaminsNaka Sales Ltd.
Flinstones Multiple Plus IronMiles Inc. Pharmaceutical Division
Flintstones Multiple VitaminsBayer Inc Consumer Care
Flintstones Multiple Vitamins Plus IronBayer Inc Consumer Care
Flintstones Multiple Vitamins TabMiles Inc. Pharmaceutical Division
Flintstones W Extra C TabMiles Inc. Pharmaceutical Division
Floradix Formula LiqFlora Manufacturing And Distributing Ltd.
Floravit - SyrFlora Manufacturing And Distributing Ltd.
FlorivaBon Geo Pharmaceuticals, Inc.
Floriva PlusBon Geo Pharmaceuticals, Inc.
Folcaps Care OneMidlothian Laboratories
Foltabs PrenatalMidlothian Laboratories
For Kids Only Chewable Multivit. Plus IronKsl Pharmaceuticals
For Kids Only Chewable Multivitamins - TabKsl Pharmaceuticals
Formula Adr-vitamin B2,b6 W Calpan TabMetagenics, Inc.
Formula CnBalance Plus, Inc.
Formula D.S.Golden Pride International
Formula DprBalance Plus, Inc.
Formula Fm Vitamins & Minerals TabMetagenics, Inc.
Formula LfNumark Laboratories, Inc.
Formula OGeneral Nutrition Canada Inc.
Formula O-care Vitamin and Mineral SupplementFor Mor International Inc.
Formula Pro-BBalance Plus, Inc.
Fortamines 10 CapsulesRougier Pharma Division Of Ratiopharm Inc
Fortamines-10 ComprimesRougier Pharma Division Of Ratiopharm Inc
Fortaplex InjKripps Pharmacy Ltd.
Fortistress TabSantÉ Naturelle (Ag) LtÉe
Forty Plus Vitamin SupplementGarden State Nutritionals
Garfield Chewable Multivits Plus Iron TabWhitehall Robins Inc.
Gemvites Jr Tab ChewablePharmavite Laboratories (1987) Inc.
Geritol LiquidGlaxosmithkline Inc
Gestamine ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
Gesticare DHAJazz Pharmaceuticals Commercial Corp.
Globucel - MethodeLes Laboratoires Swisse Inc.
Glyco-aide TabAvant Garde, Les SupplÉments
Harvest Of Values All B Complex TabHillestad Pharmaceuticals Usa
Healthy Mamabe Well Rounded Be Well RoundedMATERNAL SCIENCE, LLC
Hemarexin AmpLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hemarexin Liquid and Drinkable AmpoulesSabex Inc
Hemarexin TabLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hemenatal OBWh Nutritionals, Llc
Hi Potency B Complex W Chelated MineralsKlaire Labs Inc.
Hi Potency B52 B Complex TabCountry Health Laboratories Ltd.
Hi Potency Balanced B-100 Complex - TabLeiner Health Products
Hi Potency Stress B Tension With CLee Adams Laboratories
High Potency Vitamin B Complex + C TabVita Health Products Inc
Hill.viteHillestad Pharmaceuticals Usa
Homosistrol CapsulesMacromed Pharmicia Inc.
Hypo Vites TabPharmetics (2011) Inc.
Iberet 500Abbott
IcapsAlcon, Inc.
Icaps Time ReleaseAlcon, Inc.
Inatal AdvanceNnodum Pharmaceuticals
Inatal UltraNnodum Pharmaceuticals
Infa Drops MultivitaminsVita Health Products Inc
Infant Multivitamin DropsGeneral Nutrition Canada Inc.
Infantol DropsChurch & Dwight Company, Inc.
Infuvite Adult Multiple VitaminsSandoz
Insur-all Vitamin SupplementGarden State Nutritionals
Integra PlusUs Pharmaceutical Corporation
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoQuest Vitamins A Div Of Purity Life Health Products
Iron Polysaccharides Folic Acid DHAVirtus Pharmaceuticals
Isotonix Advanced B-complex Vitamins With Potassium and MagnesiumMarket America
Isotonix Calcium Plus FormulaMarket America
Isotonix Vitamin B-folic Acid-mineral SuppleMarket America
Itabs PlusVita Health Products Inc
Kanga Sport Vitamins B & C Plus MineralsLacombe Drugs (1992) Ltd
Kanga-B Vitamin B Group + CLacombe Drugs (1992) Ltd
Kanga-kid Multi-vitamin & MineralLacombe Drugs (1992) Ltd
Kanga-V Multivitamins & MineralsLacombe Drugs (1992) Ltd
Kenwood Liquid SupplementKenwood Laboratories (Division Of Bradley Pharmaceuticals)
Kid's Choice Children's Chewable Vitamins - TabVita Health Products Inc
Kids Stuff TabletsVita Health Products Inc
Kids Stuff With Iron TabletsVita Health Products Inc
Kimchi Vitamin Chewable MultivitaminTobico
KindervitesHerbalife International Of America
L.G.I.T.Morinda Canada
Leritone JuniorInstitut De Recherche Biologique Yves Ponroy Canada Inc.
Lipo-B-C TabMetagenics, Inc.
Liqui B ComplexTwin Laboratories Inc.
Liqui B Complex PlusTwin Laboratories Inc.
Liqui Infant VitaminsTwin Laboratories Inc.
Liqui VitaTwin Laboratories Inc.
Liquid B Complex 50Jamieson Laboratories Ltd
Livron Plus AmpouleMedic Laboratory LtÉe
Livron Plus TabMedic Laboratory LtÉe
Low Potency B Complex TabFlora Manufacturing And Distributing Ltd.
Lysamine Diet Supp Amp-tabWelcker Lyster Ltd., Division Of Technilab Inc.
M.V.I. 12Aventis Pharma Ltd.
M.V.I. PaediatricAventis Pharma Ltd.
M.V.I. PediatricHospira Worldwide, Inc.
Maltlevol 12 LiqCarter Horner Corp.
Maltlevol LiqCarter Horner Corp.
Maxi 10 TabDesbergers LtÉe, Division Of Technilab Inc.
Maxi 6 LiqDesbergers LtÉe, Division Of Technilab Inc.
Mega 13 Multivitamin FormulaVita Health Products Inc
Megavites TabIcn Pharmaceuticals
Meplex T 750Medic Laboratory LtÉe
MethaverSterling Knight Pharmaceuticals, Llc
Mini-B TabTwin Laboratories Inc.
Mor-vites TabPharmetics (2011) Inc.
Multi - N.T.O.x Formula - TabAbundance Naturally Ltd
Multi 12 InjectionSandoz Canada Incorporated
Multi BSeroyal International Inc.
Multi Enfants TabVitalab
Multi Nt-OXAbundance Marketing Ltd.
Multi RolRolmex International Inc.
Multi Vitamin - MineralEnrich International
Multi Vitamin & MineralsWn Pharmaceuticals Ltd.
Multi Vitamin and FluorideLibertas Pharma, Inc.
Multi Vitamin Drops With FluorideSeton Pharmaceuticals
Multi Vitamin Drops With Fluoride and IronSeton Pharmaceuticals
Multi Vitamin Drops With Fluoride With IronStratus Pharmaceuticals
Multi Vitamin Plus IronWn Pharmaceuticals Ltd.
Multi Vitamin With FluorideQualitest
Multi Vitamin-mineral FormulaVita Health Products Inc
Multi Vitamin, Iron and FluorideMayne Pharma
Multi Vitamines - LiqLand Art Inc.
Multi Vitamins & MineralsWn Pharmaceuticals Ltd.
Multi Vite Liq AdultPharmetics (2011) Inc.
Multi Vite Liq JuniorPharmetics (2011) Inc.
Multi-11Sandoz Canada Incorporated
Multi-12 PediatricSabex Inc
Multi-12/k1 PediatricSandoz Canada Incorporated
Multi-min Electro C Pow Plus B2Quest Vitamins A Div Of Purity Life Health Products
Multi-vit With FluorideA S Medication Solutions
Multi-vit With Fluoride and IronQualitest
Multi-vitaminLLC Federal Solutions
Multi-vitamin Dietary SupplementGarden State Nutritionals
Multi-vitamin Drops With Fluoride and IronMethod Pharmaceuticals
Multi-vitamin FluorideStratus Pharmaceuticals
Multi-vitamin Fluoride and Iron DropsBoca Pharmacal, Inc.
Multi-vitamin Fluoride DropsH.J. Harkins Company
Multi-vitamin With FluorideGolden State Medical Supply
Multi-vitamines Enfants ComprimeHerbes Universelles Inc.
Multi-vitaminsWn Pharmaceuticals Ltd.
Multi-vitamins With MineralsWn Pharmaceuticals Ltd.
Multiple Vitamin Plus Minerals TabHall Laboratories, Ltd.
Multiple Vitamin TabAdams Laboratories
Multiple VitaminsGfr Pharma Ltd.
Multiple Vitamins & Minerals TabletsPharmetics (2011) Inc.
Multiple Vitamins and Minerals TabRandle Pharmaceutical Inc.
Multiple Vitamins Plus Iron for WomenPharmetics (2011) Inc.
Multiple Vitamins Plus Iron TabHall Laboratories, Ltd.
Multiple Vitamins TabHall Laboratories, Ltd.
Multiple Vitamins W Minerals TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins With IronStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins With Minerals TabletsPharmetics (2011) Inc.
MultisolLes Laboratoires Vachon Inc.
Multivit Et Fer Ampoules Et ComprimesNobel Pharm Enr.
Multivit-liqPharmalab Inc.
MultivitaminLaboratoires Confab Inc
Multivitamin Drops With FluorideSancilio & Company, Inc.
Multivitamin With FluoridePure Tek Corporation
MultivitaminesRolmex International Inc.
Multivitamines Et MinerauxLe Groupe M. Vachon Inc.
Multivitamines Et Mineraux Junior RegulierLaboratoire Riva Inc
Multivitamines Et Mineraux Reguliers / Regular Multivitamins and MineralsVita Health Products Inc
Multivitamines Plus Fer Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
Multivitamines Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
Multivitamins and Minerals - CompleteVita Health Products Inc
Multivitamins and Multiminerals Formula Regular TabletPharmetics (2011) Inc.
Multivitamins for ChildrenQuest Vitamins A Div Of Purity Life Health Products
Multivitamins W IronRandle Pharmaceutical Inc.
MvcSancilio & Company Inc.
Mvc-fluorideSancilio & Company Inc.
Myhephron Dialysis and Stress SupplementMartin Ekwealor Pharmaceu
Mynephrocaps Dialysis/stress Vitamin SupplementMartin Ekwealor Pharmaceuticals, Inc.
N.E.U. ComplexAbundance Marketing Ltd.
Nata KompleteWh Nutritionals, Llc
NatafortMission Pharmacal
NataviteSchein Pharmaceutical Canada Inc.
Neo Bex ElixirNeolab Inc
Neo Vites TabNeolab Inc
Neo-bexNeolab Inc
Neo-bex InjectableBrostel Inc.
Neo-vites & Minerals TabNeolab Inc
NephrocapsCardinal Health
Nutrifer Plus TabletsWyeth Ayerst Canada Inc.
Nutrilite Double XNutrilite, A Division Of Access Business Group, Llc
Nutrol-B-complexRolmex International Inc.
O-cal Fa MultivitaminPharmics, Inc.
O-cal Prenatal VitaminPharmics, Inc.
OnccorSimone Protective Pharmaceuticals, Inc.
One A Day Advance AdultsBayer Inc Consumer Care
One A Day Advance Adults 50+Bayer Inc Consumer Care
One A Day Advance FemBayer Inc Consumer Care
One A Day TabCountry Health Laboratories Ltd.
Orange Flavored Crystal Chews TabJeunique International Inc.
Orifer FSanofi Aventis
Original Bioscal Forte Multi-vitamin Supplement CapsulesCarram Inc.
Orti BSeroyal International Inc.
P.N.P. Vitamin DrinkChanges International
P.R.O. ComplexAbundance Marketing Ltd.
Paramettes Chewable Multivitamins Plus IronWyeth Ayerst Canada Inc.
Paramettes Chewable Multivits With Iron TabWhitehall Robins Inc.
Paramettes Multivits Plus Iron Tab (teens)Whitehall Robins Inc.
Paramettes SyrupWyeth Ayerst Canada Inc.
Pediatric Infuvite Multiple VitaminsSandoz
Pediatric Infuvite Multiple Vitamins for InfusionSandoz
Permathene-12 - CapletCca Industries, Inc
Phosthenine Vitamines Et Fer (ampoules Buvable)Laboratoires Cortunon Inc.
Phytofortis + Calcium A-DPhyto Health Corporation
Phytoplex B LiqPhyto Health Corporation
PhytopureLaboratoire Lalco Inc.
PM CapsNew Vision Nutritionals Company
PNF-FirstAcella Pharmaceuticals, LLC
Pnv Ferrous Fumarate Docusate Folic AcidVirtus Pharmaceuticals
Pnv Prenatal Plus MultivitaminClinical Solutions Wholsesale
Pnv Prenatal VitaminSancilio & Company Inc.
Pnv Prenatal Vitamin Plus Vitamin ASancilio & Company Inc.
Pnv-selectAcella Pharmaceuticals, LLC
Poly-VI-sol DropsMead Johnson Nutritionals
Polymine Avec Zinc Et CuivreLes Laboratoires Vachon Inc.
Potassium Plus Vit B ComplexAnabolic Laboratories Inc.
Prefera Ob Plus DHAAlaven Pharmaceutical
PreferaobMeda Pharmaceuticals Ltd
Preferaob Plus DHAAlaven Pharmaceutical
PregvitDuchesnay Inc.
Pregvit Folic 4Duchesnay Inc.
Pregvit Folic 5Duchesnay Inc.
Prenatal 19Nationwide Laboratories
Prenatal Mega AntioxidantUsana Health Services, Inc.
Prenatal PlusBlenheim Pharmacal, Inc.
Prenatal Plus IronMajor
Prenatal Vitamins Plusbryant ranch prepack
Prenatal Vitamins Plus Low IronPatrin Pharma
Prenate EliteAvion Pharmaceuticals, Llc
Prenate StarAvion Pharmaceuticals, Llc
PreplusVirtus Pharmaceuticals
Preque 10Actavis Pharma Company
PretabVirtus Pharmaceuticals
Prevital TabBio Vita
Purevit Dualfe PlusPure Tek Corporation
Q.T. Vitamin and Mineral Drink MixGarden State Nutritionals
Reaphirm Plant Source DHAEverett Laboratories, Inc.
Reno CapsNnodum Pharmaceuticals
ReplaviteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Revit Plus CapIcn Pharmaceuticals
Revit TabIcn Pharmaceuticals
Revitex Ampoules Et ComprimesLes Produits Gerbex Inc.
Revival 1 TabBio Vita
Right Choice A.M. Multi Formula - CapletBody Wise International Llc
Se-natal 19Seton Pharmaceuticals
Se-natal 19 ChewableSeton Pharmaceuticals
Se-natal OneSeton Pharmaceuticals
Se-tan PlusSeton Pharmaceuticals
Sibergin B - CapPharmavite
Somarexin and C 1000Laboratoire Lalco Inc.
Somavit Brand Vitamins and Minerals ComplexSoma Health Products
Sopalamine/3b Plus CTechnilab Pharma Inc.
Spectrum 2 CapNf Formulas Inc.
Stress B & C CapletHealth Wise Nutrition Inc.
Stress B Capsules With Vitamin CRheingold Food International Ltd.
Stress B Complex With C, E & IronPharmavite
Stress B With 1000 Mg Vitamin CHolista Health (Canada) Inc.
Stress B&c TabBioforce Canada Inc.
Stress Complex 600 Avec Vit E Cuivre ZincFrega Inc.
Stress Ctr SrtBioenergy Inc.
Stress FormulaVita Health Products Inc
Stress Formula + IronVita Health Products Inc
Stress Formula B-comp + 500mg Vit C TabQuest Vitamins A Div Of Purity Life Health Products
Stress Formula Multi-B Comp + 500mg Vit C CapQuest Vitamins A Div Of Purity Life Health Products
Stress Formula Multivitamin Tablets USPLeiner Health Products
Stress Formula TabNatures Sunshine Products, Inc.
Stress Formula Vit B With C ComplexWatkins Incorporated
Stress Forte Plus Lipotropic FactorsDouglas Laboratories
Stress TabVita Health Products Inc
Stress TabletsD.C. Labs Limited
Stress Vitamin B With C Complex TabletsPurity Life Health Products A Division Of Sunopta Inc.
StressmatesTwin Laboratories Inc.
Strovite Forte CapletEverett Laboratories, Inc.
Strovite One CapletsEverett Laboratories, Inc.
Sun-rype VitaburstSun Rype Products Ltd.
Super B Compound W 500mg Vit CGahler Enterprises Ltd.
Super Charged EnergySimone Protective Pharmaceuticals, Inc.
Super Daily No 2W.R. Enterprises Inc.
Super PantoplexNu Life Nutrition Ltd.
Super Stress CapsulesRheingold Food International Ltd.
Super Stress Mega B Plus 1000mg Vit C TabQuest Vitamins A Div Of Purity Life Health Products
Super Vitalex Ampoule BuvableCarmaran LtÉe
Super-pote Vitamin SupplementGarden State Nutritionals
Supplement De Multivitamines Infusion Arome Fruits RougesYves Rocher Inc.
Supravite 10ml AmpouleNobel Pharm Enr.
Supravite Bouteille 250mlNobel Pharm Enr.
Supravite C 1000Nobel Pharm Enr.
Supravite Pour EnfantsPharmalab Inc.
Supravite Stress Avec Vit EPharmalab Inc.
Supravite Stress Avec Vit E Cuivre Et ZincPharmalab Inc.
Supravite Stress Avec Vit E Et FerPharmalab Inc.
Surbex 500 FilmtabAbbott
Surbex-500 With IronAbbott
Surbex-500 With ZincAbbott
Swical-energy-2Les Laboratoires Swisse Inc.
T.R.I. B-plex SrcAnabolic Laboratories Inc.
Tandem ObUs Pharmaceutical Corporation
Tandem PlusUs Pharmaceutical Corporation
Tender Age Multi VitaminsJamieson Laboratories Ltd
Time Release B 100 Compound - TabletHealth Wise Nutrition Inc.
Timed Release B Complex 100 SrtJamieson Laboratories Ltd
Timed Release B-complex 100Great Earth Companies, Inc.
Timed Release B-complex 50Great Earth Companies, Inc.
Tini-cal AmpoulesPharmetics (2011) Inc.
Toni Com LiqVitalab
Tonicol Et A-D-C Ampoules/comprimesDistributions Multi Pro Inc.
Tonimol Cap LiqHerbes Universelles Inc.
TriadvanceTrigen Laboratories, Inc.
Tricare PrenatalMedecor Pharma, Llc
Trinatal GtTrigen Laboratories, Inc.
Twin Ultra Liquid Fruit Punch FlavorTwin Laboratories Inc.
Twin Ultra Liquid Grape FlavorTwin Laboratories Inc.
Twin Ultra Liquid Lemon-lime FlavorTwin Laboratories Inc.
Twin Ultra Liquid Orange FlavorTwin Laboratories Inc.
Ultimatecare One NfTrigen Laboratories, Inc.
Ultra EnerforceNutribon (1986) Inc.
Ultra HrNatural Organics Inc.
Usana Megavitamin Tablets - TabUsana Health Sciences, Inc.
Vasodyn TabNutri Dyn Products Ltd.
Viamon Ampoules Et ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
Vigo Multivitamins Drops/lozengeAshbury Research Corporation
Vimeral TabIcn Pharmaceuticals
Virt-capsVirtus Pharmaceuticals
Virt-PNVirtus Pharmaceuticals
Virt-vite PlusVirtus Pharmaceuticals
Vit B Complex CtrBioenergy Inc.
Vit B Complex Plus Vit C 550mgHall Laboratories, Ltd.
Vit-HA Multi Vitamin and Zinc SupplementRheingold Food International Ltd.
Vita B + C 500 TabLaboratoire Romilo
Vita B Complex TabNutrimetics International (Canada) Inc.
Vita Day TabJamieson Laboratories Ltd
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Vita-B-75 CapLes Laboratoires Vachon Inc.
Vita-worth B-complex TabletsGeneral Nutrition Canada Inc.
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Vitachrom GcNikken Usa, Incorporated
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Vitafer - LiqFrega Inc.
Vitaflex Dietary SuplementHome Shopping Network Direct
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Vitafol OneEverett Laboratories, Inc.
Vitafol PlusEverett Laboratories, Inc.
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Vitalife - CapsuleHolista Health (Canada) Inc.
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Vitamin B + C CapFinlandia Consultants
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Vitamin B Complex + C 300mg CapRandle Pharmaceutical Inc.
Vitamin B Complex + C 600mg TabRandle Pharmaceutical Inc.
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Vitamin B Complex 50Gfr Pharma Ltd.
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Vitamin B Complex W C 300mg TabLee Adams Laboratories
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CAS number83-88-5
WeightAverage: 376.3639
Monoisotopic: 376.138284392
Chemical FormulaC17H20N4O6
CC1=C(C)C=C2N(C[[email protected]](O)[[email protected]](O)[[email protected]](O)CO)C3=NC(=O)NC(=O)C3=NC2=C1

For the treatment of ariboflavinosis (vitamin B2 deficiency).

Structured Indications

Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolising of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. Riboflavin also helps in the prevention or treatment of many types of eye disorders, including some cases of cataracts.

Mechanism of action

Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.

TargetKindPharmacological actionActionsOrganismUniProt ID
Riboflavin kinaseProteinyes
HumanQ969G6 details
Riboflavin synthaseProteinyes
Escherichia coli (strain K12)P0AFU8 details
Flavin reductase (NADPH)Proteinyes
product of
HumanP30043 details
Related Articles

Vitamin B2 is readily absorbed from the upper gastrointestinal tract.

Volume of distributionNot Available
Protein binding




Route of eliminationNot Available
Half life

66-84 minutes

ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwayCategorySMPDB ID
Riboflavin MetabolismMetabolicSMP00070
Pharmacogenomic Effects/ADRs Not Available
Drug Interactions
DrugInteractionDrug group
Porfimer sodiumRiboflavin may increase the photosensitizing activities of Porfimer.Approved, Investigational
VerteporfinRiboflavin may increase the photosensitizing activities of Verteporfin.Approved, Investigational
Food InteractionsNot Available
Synthesis Reference

Hansgeorg Ernst, Wolfram Schmidt, Joachim Paust, "Preparation of riboflavin." U.S. Patent US4567261, issued August, 1958.

General References
  1. Zempleni J, Galloway JR, McCormick DB: Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr. 1996 Jan;63(1):54-66. [PubMed:8604671 ]
External Links
ATC CodesA11HA04 — Riboflavin (vit b2)
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSDownload (39.4 KB)
Clinical Trials
Clinical Trials
1CompletedNot AvailableHIV-1 Infections / Human Immunodeficiency Virus (HIV) Infections / Mycobacterium avium complex infection1
1CompletedDiagnosticHealthy Volunteers1
1CompletedTreatmentCancers / Metastases1
1CompletedTreatmentUlcerative keratitis1
1Not Yet RecruitingBasic ScienceAging / Mineral deficiency / Vitamin Deficiency1
1, 2RecruitingOtherHypercholesterolemia, Familial / Hypertriglyceridemias1
1, 2RecruitingPreventionKeratolysis1
1, 2RecruitingTreatmentAutoimmune Diseases / Chemical Injuries / Lupus Erythematosus, Systemic / Ocular Cicatricial Pemphigoid / Other Autoimmune Diseases / Rheumatoid Arthritis / Stevens Johnson Syndrome / Unspecified Complication of Corneal Transplant1
1, 2SuspendedTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
2Active Not RecruitingTreatmentKeratoconus1
2Active Not RecruitingTreatmentKeratoconus / Post-Refractive Ectasia1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentCancer, Breast1
2CompletedTreatmentCentral Serous Chorioretinopathy (CSC)1
2Not Yet RecruitingTreatmentSports-related Concussion1
2RecruitingPreventionAmnestic / Cognitive Disorders / Delayed Emergence From Anesthesia / Delirium / Delirium, Dementia / Delirium, Dementia, Amnestic, Cognitive Disorders1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2Unknown StatusTreatmentCorneal Ectasia / Ectasia / Keratoconus1
2Unknown StatusTreatmentMyocardial Infarction (MI)1
2WithdrawnOtherCompliance / Pain, Chronic1
2, 3CompletedTreatmentAcidosis, Respiratory1
2, 3CompletedTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Mortality1
2, 3Unknown StatusTreatmentEctasia / Keratoconus1
2, 3WithdrawnTreatmentCorneal Ectasia / Progressive Keratoconus1
3Active Not RecruitingTreatmentCorneal Ectasia / Keratoconus3
3Active Not RecruitingTreatmentKeratoconus1
3CompletedPreventionComplications, Pregnancy / Human Immunodeficiency Virus (HIV) Infections1
3CompletedPreventionCoronary Artery Bypass Grafting (CABG) Surgery / Left Ventricular Dysfonction1
3CompletedTreatmentDiarrheal Illnesses / Growth Faltering / Respiratory Illness1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis, Pulmonary1
3CompletedTreatmentHydatidiform Mole1
3CompletedTreatmentProgressive Keratoconus1
3RecruitingTreatmentCrohn's Disease (CD) / Oral Ulcers1
3TerminatedNot AvailableKeratoconus and Ectasia1
3TerminatedTreatmentCorneal Ectasia / Keratoconus1
3TerminatedTreatmentMultiple System Atrophy (MSA)1
3Unknown StatusNot AvailableAnemias / Low Birth Weight / Neonatal Mortality1
3Unknown StatusTreatmentAlzheimer's Disease (AD) / Down Syndrome (DS)1
3Unknown StatusTreatmentUnstable Corneas1
4CompletedHealth Services ResearchAcidosis, Respiratory / Aids / Human Immunodeficiency Virus (HIV) Infections / Lipodystrophies1
4CompletedTreatmentDiabetic Peripheral Neuropathic Pain1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentProgressive Keratoconus / Thin Corneas1
4CompletedTreatmentSmoking Addiction1
4RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4WithdrawnTreatmentNephritis / Proteinuria / Systemic Lupus Erythematosus (SLE)1
Not AvailableCompletedNot AvailableFruste Keratoconus / Risk of Ectasia1
Not AvailableCompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedPreventionNeural Tube Defects (NTDs)1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections2
Not AvailableNot Yet RecruitingTreatmentBreast Cancer Metastatic / Metastatic Breast Cancer (MBC)1
Not AvailableRecruitingTreatmentEctasia / Keratoconus1
Not AvailableRecruitingTreatmentTemporomandibular Joint Disorders1
Not AvailableTerminatedTreatmentInfectious Keratitis1
Not AvailableUnknown StatusPreventionBrittle Cornea Syndrome / Ehlers-Danlos Syndrome Type 61
Not AvailableUnknown StatusTreatmentSports Related Concussion1
Not AvailableWithdrawnPreventionHuman Immunodeficiency Virus (HIV) Infections1
ManufacturersNot Available
Dosage forms
Tablet, extended releaseOral
Injection, solutionIntramuscular; Intravenous
Powder, for solutionIntramuscular; Intravenous
Powder, for solutionIntravenous
Tablet, effervescentOral
LiquidIntramuscular; Intravenous
Tablet, chewableOral
Injection, powder, lyophilized, for solutionIntravenous
Liquid; tabletOral
Solution / dropsOral
Granule, effervescentOral
SolutionIntramuscular; Intravenous
Injection, solutionIntravenous
Solution / dropsOphthalmic1.46 mg/mL
Tablet, coatedOral
CapsuleOral50 mg
SolutionIntramuscular; Intravenous50 mg
TabletOral10 mg
TabletOral5 mg
TabletOral25 mg
Capsule, extended releaseOral
Capsule; liquidOral
Tablet, extended releaseOral200 mg
CapsuleOral100 mg
Capsule, gelatin coatedOral
Capsule, liquid filledOral
InjectionIntramuscular; Intravenous
TabletOral50 mg
TabletOral100 mg
TabletOral4 mg
Tablet, film coatedOral
Unit descriptionCostUnit
Riboflavin powder0.44USD g
Riboflavin 100 mg tablet0.09USD tablet
Riboflavin 50 mg tablet0.08USD tablet
Vitamin b-2 50 mg tablet0.08USD tablet
Ribo 100 mg tablet0.04USD tablet
Vitamin b-2 25 mg tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Experimental Properties
melting point (°C)280 dec °CPhysProp
water solubility84.7 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-1.46HANSCH,C ET AL. (1995)
logS-3.68ADME Research, USCD
pKa10.2BUDAVARI,S ET AL. (1996)
Predicted Properties
Water Solubility0.657 mg/mLALOGPS
pKa (Strongest Acidic)6.97ChemAxon
pKa (Strongest Basic)0.76ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area155.05 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity96.27 m3·mol-1ChemAxon
Polarizability37.5 Å3ChemAxon
Number of Rings3ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Human Intestinal Absorption+0.9156
Blood Brain Barrier-0.8495
Caco-2 permeable-0.7122
P-glycoprotein substrateSubstrate0.7414
P-glycoprotein inhibitor INon-inhibitor0.8708
P-glycoprotein inhibitor IINon-inhibitor0.9466
Renal organic cation transporterNon-inhibitor0.9279
CYP450 2C9 substrateNon-substrate0.7819
CYP450 2D6 substrateNon-substrate0.8435
CYP450 3A4 substrateNon-substrate0.522
CYP450 1A2 substrateInhibitor0.8531
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9516
CYP450 2C19 inhibitorInhibitor0.7302
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9203
Ames testNon AMES toxic0.804
BiodegradationNot ready biodegradable0.9641
Rat acute toxicity1.6067 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9395
hERG inhibition (predictor II)Non-inhibitor0.5362
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Mass Spec (NIST)Download (11.3 KB)
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-004i-0019000000-86365dedafa031aa7787View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0006-4390000000-ac1b59ab7cc2209f4241View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-00dj-4900000000-72d33eb27b9bd6a13d9eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-004l-0569000000-874b71fdc78d04853bf0View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0a4i-0091000000-a82c54d3153103fcdb1fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , negativesplash10-0a4i-0090000000-2aff124ee1fc62c13844View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , negativesplash10-0a4i-0090000000-f8b29c3e2c601a944a6cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , negativesplash10-0a4i-0090000000-4e8c9bd38ea0f5ae9a94View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-0006-0092000000-1f1be5508c1d50d8dff7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-0006-0092000000-74bf0b86efe72fe37198View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-057i-0069000000-bb0522be4472e049dbc5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-057i-0069000000-208440cf501d0b9050d7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-006x-0029000000-8c3d72bf2a06d79bbd31View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-006x-0039000000-7d8dc991995cfc262ad1View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-0006-0092000000-4f524f1e6c8131751c92View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-0560-0069000000-edc332be3fcbf6d0c14bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-0006-0009000000-2e6bf027d624900baabdView in MoNA
LC-MS/MSLC-MS/MS Spectrum - , positivesplash10-004i-0239000000-659ca9fae9643f3ce73dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-qTof , PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
DescriptionThis compound belongs to the class of organic compounds known as flavins. These are compounds containing a flavin (7,8-dimethyl-benzo[g]pteridine-2,4-dione) moiety, with a structure characterized by an isoalloaxzine tricyclic ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPteridines and derivatives
Sub ClassAlloxazines and isoalloxazines
Direct ParentFlavins
Alternative ParentsQuinoxalines / Pyrimidones / Pyrazines / Benzenoids / Vinylogous amides / Heteroaromatic compounds / Secondary alcohols / Lactams / Polyols / Azacyclic compounds
SubstituentsFlavin / Diazanaphthalene / Quinoxaline / Pyrimidone / Pyrazine / Pyrimidine / Benzenoid / Heteroaromatic compound / Vinylogous amide / Secondary alcohol
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptorsflavin (CHEBI:17015 ) / Water-soluble vitamins (C00255 )


Pharmacological action
General Function:
Riboflavin kinase activity
Specific Function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH...
Gene Name:
Uniprot ID:
Uniprot Name:
Riboflavin kinase
Molecular Weight:
17623.08 Da
  1. Werner R, Manthey KC, Griffin JB, Zempleni J: HepG2 cells develop signs of riboflavin deficiency within 4 days of culture in riboflavin-deficient medium. J Nutr Biochem. 2005 Oct;16(10):617-24. [PubMed:16081269 ]
  2. Solovieva IM, Kreneva RA, Errais Lopes L, Perumov DA: The riboflavin kinase encoding gene ribR of Bacillus subtilis is a part of a 10 kb operon, which is negatively regulated by the yrzC gene product. FEMS Microbiol Lett. 2005 Feb 1;243(1):51-8. [PubMed:15668000 ]
  3. Ishchuk OP, Iatsyshyn VIu, Dmytruk KV, Voronovs'kyi AIa, Fedorovych DV, Sybirnyi AA: [Construction of the flavinogenic yeast Candida famata strains with high riboflavin kinase activity using gene engineering]. Ukr Biokhim Zh (1999). 2006 Sep-Oct;78(5):63-9. [PubMed:17290783 ]
  4. Sandoval FJ, Roje S: An FMN hydrolase is fused to a riboflavin kinase homolog in plants. J Biol Chem. 2005 Nov 18;280(46):38337-45. Epub 2005 Sep 23. [PubMed:16183635 ]
  5. Bertollo CM, Oliveira AC, Rocha LT, Costa KA, Nascimento EB Jr, Coelho MM: Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models. Eur J Pharmacol. 2006 Oct 10;547(1-3):184-91. Epub 2006 Jul 26. [PubMed:16962092 ]
  6. Hirano G, Izumi H, Yasuniwa Y, Shimajiri S, Ke-Yong W, Sasagiri Y, Kusaba H, Matsumoto K, Hasegawa T, Akimoto M, Akashi K, Kohno K: Involvement of riboflavin kinase expression in cellular sensitivity against cisplatin. Int J Oncol. 2011 Apr;38(4):893-902. doi: 10.3892/ijo.2011.938. Epub 2011 Feb 9. [PubMed:21308351 ]
Escherichia coli (strain K12)
Pharmacological action
General Function:
Riboflavin synthase activity
Specific Function:
Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
Gene Name:
Uniprot ID:
Uniprot Name:
Riboflavin synthase
Molecular Weight:
23444.77 Da
  1. Kim RR, Illarionov B, Joshi M, Cushman M, Lee CY, Eisenreich W, Fischer M, Bacher A: Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion. J Am Chem Soc. 2010 Mar 10;132(9):2983-90. doi: 10.1021/ja908395r. [PubMed:20143812 ]
  2. Long Q, Ji L, Wang H, Xie J: Riboflavin biosynthetic and regulatory factors as potential novel anti-infective drug targets. Chem Biol Drug Des. 2010 Apr;75(4):339-47. doi: 10.1111/j.1747-0285.2010.00946.x. Epub 2010 Feb 8. [PubMed:20148904 ]
Pharmacological action
product of
General Function:
Riboflavin reductase (nadph) activity
Specific Function:
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
Gene Name:
Uniprot ID:
Uniprot Name:
Flavin reductase (NADPH)
Molecular Weight:
22119.215 Da
  1. Russell TR, Demeler B, Tu SC: Kinetic mechanism and quaternary structure of Aminobacter aminovorans NADH:flavin oxidoreductase: an unusual flavin reductase with bound flavin. Biochemistry. 2004 Feb 17;43(6):1580-90. [PubMed:14769034 ]
  2. van Pee KH, Patallo EP: Flavin-dependent halogenases involved in secondary metabolism in bacteria. Appl Microbiol Biotechnol. 2006 May;70(6):631-41. Epub 2006 Mar 17. [PubMed:16544142 ]


Pharmacological action
General Function:
Serotonin binding
Specific Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Gene Name:
Uniprot ID:
Uniprot Name:
Amine oxidase [flavin-containing] A
Molecular Weight:
59681.27 Da
  1. Strolin Benedetti M, Tipton KF, Whomsley R: Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected? Fundam Clin Pharmacol. 2007 Oct;21(5):467-80. [PubMed:17868200 ]
Pharmacological action
General Function:
Protein complex binding
Specific Function:
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
Gene Name:
Uniprot ID:
Uniprot Name:
Methylenetetrahydrofolate reductase
Molecular Weight:
74595.895 Da
  1. Bates CJ, Fuller NJ: The effect of riboflavin deficiency on methylenetetrahydrofolate reductase (NADPH) (EC and folate metabolism in the rat. Br J Nutr. 1986 Mar;55(2):455-64. [PubMed:3676170 ]
  2. Macdonald HM, McGuigan FE, Fraser WD, New SA, Ralston SH, Reid DM: Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density. Bone. 2004 Oct;35(4):957-64. [PubMed:15454103 ]


Pharmacological action
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
Uniprot ID:
Uniprot Name:
Solute carrier family 22 member 6
Molecular Weight:
61815.78 Da
  1. Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. [PubMed:9880528 ]
Drug created on June 13, 2005 07:24 / Updated on July 18, 2017 16:45