Identification
NamePantothenic acid
Accession NumberDB01783  (EXPT02501)
TypeSmall Molecule
GroupsNutraceutical, Vet Approved
Description

Pantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. For many animals, pantothenic acid is an essential nutrient. Animals require pantothenic acid to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. Pantothenic acid is the amide between pantoic acid and β-alanine. Small quantities of pantothenic acid are found in nearly every food, with high amounts in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. It is commonly found as its alcohol analog, the provitamin panthenol, and as calcium pantothenate. Pantothenic acid is an ingredient in some hair and skin care products. Only the dextrorotatory (D) isomer of pantothenic acid possesses biologic activity. The levorotatory (L) form may antagonize the effects of the dextrorotatory isomer. [Wikipedia]

Structure
Thumb
Synonyms
(+)-Pantothenic acid
D-pantothenic acid
Pantothenate
Vitamin B5
External IDs Not Available
Product Ingredients
IngredientUNIICASInChI KeyDetails
Calcium pantothenate568ET80C3D 137-08-6FAPWYRCQGJNNSJ-UBKPKTQASA-LDetails
Product Images
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acti Pantothenic Acid 1000 Timed CapletTablet1 gOralActi Form Ltd.1991-12-312005-03-21Canada
Acti-pantothenic Acid 300 Caplet 300mgTablet300 mgOralActi Form Ltd.1991-12-312005-03-21Canada
Calcium Pantothenate Tab 250mgTablet250 mgOralTrophic Canada Ltd.1991-12-311996-09-17Canada
Calpan Tab 100mgTablet100 mgOralIcn Pharmaceuticals1973-12-311998-08-13Canada
Calpan Tab 250mgTablet250 mgOralIcn Pharmaceuticals1973-12-311998-08-13Canada
D Pantothenic Acid Tab 100mgTablet100 mgOralGahler Enterprises Ltd.1984-12-312000-08-01Canada
D-pantothenic Acid 250mgCapsule250 mgOralWn Pharmaceuticals Ltd.2001-10-072007-08-07Canada
D-pantothenic Acid 250mg CapCapsule250 mgOralGahler Enterprises Ltd.1993-12-312008-07-17Canada
D'pantothenic Acid Srt 1000mgTablet, extended release1 gOralGahler Enterprises Ltd.1981-12-312001-07-26Canada
Pantacid Tab 250mgTablet250 mgOralLes Produits Naturels Suisse Inc.1985-12-311996-09-09Canada
Pantothenic AcidCapsule250 mgOralSeroyal International Inc.1993-12-312008-10-09Canada
Pantothenic Acid 100 Mg TabletsTablet100 mgOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
Pantothenic Acid 100mgTablet100 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Pantothenic Acid 250mgTablet250 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Pantothenic Acid 250mgTablet250 mgOralGeneral Nutrition Canada Inc.1997-08-132005-08-05Canada
Pantothenic Acid 500 Caplet 500mgTablet500 mgOralHealth Wise Nutrition Inc.1994-12-311998-08-25Canada
Pantothenic Acid 500 mgCapsule500 mgOralFlora Manufacturing And Distributing Ltd.2002-03-152007-08-03Canada
Pantothenic Acid 500mgTablet500 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Pantothenic Acid Cap 250mgCapsule250 mgOralQuest Vitamins A Div Of Purity Life Health Products1980-12-312001-07-06Canada
Pantothenic Acid Caps 100mgCapsule100 mgOralTwin Laboratories Inc.1995-12-312002-09-11Canada
Pantothenic Acid Caps 250mgCapsule250 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Pantothenic Acid Ctr Srt 500mgTablet, extended release500 mgOralBioenergy Inc.1979-12-311998-06-03Canada
Pantothenic Acid Tab 100mgTablet100 mgOralVita Health Products Inc1976-12-312002-07-31Canada
Pantothenic Acid Tab 100mg Nu LifeTablet100 mgOralNu Life Nutrition Ltd.1964-12-312000-03-03Canada
Pantothenic Acid Tab 200mgTablet200 mgOralKlaire Labs Inc.1984-12-311999-01-18Canada
Pantothenic Acid Tab 250mgTablet250 mgOralNutri West Products Ltd.1991-12-312002-06-14Canada
Pantothenic Acid Tab 500mgTablet, extended release500 mgOralPure Life International Prods Inc.1992-12-312001-08-07Canada
Pantothenic Acid Tablets 300mgTablet300 mgOralNu Life Nutrition Ltd.1986-12-312005-03-15Canada
Pantothenic Acid-S Tab 100mgTablet100 mgOralNutri West Products Ltd.1993-12-311997-08-05Canada
Vita-tenic Cap 300mgCapsule300 mgOralLes Laboratoires Vachon Inc.1989-12-311997-02-06Canada
Vitamin B5 (pantothenic Acid) Tab 250mgTablet250 mgOralJamieson Laboratories Ltd1993-12-312001-09-14Canada
Vitamin B5 Tab 50mg USP ChewableTablet50 mgOralLab Gernetic Int Ltee1986-12-311997-02-21Canada
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
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B Complex 50+ CapletTabletOralHealth Wise Nutrition Inc.1994-12-312002-07-18Canada
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B Complex Plus C 300mg TabTabletOralNutricorp International2000-08-012009-08-05Canada
B Complex TabletsTabletOralGolden Neo Life Diamite International, Limited1979-12-312000-08-06Canada
B Complex W C Forte CapCapsuleOralEverest Pharmaceuticals Ltd.1980-12-311999-07-14Canada
B Complex W Vit C W Non-med Yeast&liver TabTabletOralPharmavite1991-12-311997-09-04Canada
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B Complex With C 300mgCapsuleOralVita Health Products Inc1985-12-312008-08-05Canada
B Complex With C 300mg TabTabletOralPharmavite1987-12-312005-07-15Canada
B Complex With C 550mgCapsuleOralVita Health Products Inc1990-12-312002-07-31Canada
B Compound 50mg TabTabletOralGahler Enterprises Ltd.1987-12-312009-09-28Canada
B Plus C 300mg Timed ReleaseTablet, extended releaseOralVita Health Products Inc1981-12-312008-08-05Canada
B Stress C + Iron & ViteTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1990-12-312004-07-26Canada
B Totum 500TabletOralDesbergers LtÉe, Division Of Technilab Inc.1966-12-311999-09-17Canada
B VirolElixirOralRolmex International Inc.1975-12-312008-07-09Canada
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B-100 Hi Potency B Vitamins TabTabletOralNatrol, Inc.1994-12-312009-05-07Canada
B-100 Vitamin SupplementTablet, extended releaseOralGarden State Nutritionals1998-09-222000-06-07Canada
B-50 ComplexTabletOralVita Health Products Inc1977-12-312004-07-26Canada
B-50 Complex TabTabletOralVita Health Products Inc1988-12-311998-07-22Canada
B-50 Hi Potency B Vitamins TabTabletOralNatrol, Inc.1994-12-312006-09-26Canada
B-complexTabletOralEnrich International1999-11-112001-09-28Canada
B-complex 100TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
B-complex 50TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
B-complex TabTabletOralNatures Sunshine Products, Inc.1995-12-312009-08-07Canada
B-complex TabletsTabletOralShaklee Corporation1983-12-312000-01-24Canada
B-complex With Vitamin C, Biotin, Folic AcidTabletOralWn Pharmaceuticals Ltd.2001-11-232009-09-28Canada
B-complex-50 TabTabletOralJr Carlson Labs Inc1998-10-252005-09-15Canada
B-plexTabletOralWn Pharmaceuticals Ltd.1999-10-202000-01-28Canada
B-plus - TabTabletOralChampion's Choice Advanced Nutrition Inc.1997-06-111999-08-28Canada
B50 B Complex TabTabletOralNutristar Health Products (1987) Inc.1983-12-311996-09-09Canada
B50 ComplexCapsuleOralPreferred Nutrition Inc.2003-10-292005-08-04Canada
BacminTablet, coatedOralMarnel Pharmaceuticals, Llc2000-04-01Not applicableUs
Balanced B 125 SrtTablet, extended releaseOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
Balanced B-100 B-complex Vitamins TabTabletOralPharmavite1991-12-312003-07-30Canada
Balanced B-100 Timed ReleaseTabletOralPharmavite2000-10-242005-07-15Canada
Balanced B-50 B-complex Vitamins TabTabletOralPharmavite1995-12-312000-08-24Canada
Balanced B-50 B-complex Vitamins, Timed ReleTabletOralPharmavite1995-12-312006-07-05Canada
Balanced B-50 ComplexTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Balanced B-complex Vit + Vit C&e TabTabletOralPharmavite1991-12-312006-07-05Canada
Balanced B100TabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Balanced B50 ComplexTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Beminal With C Fortis CapCapsuleOralWyeth Ayerst Canada Inc.1994-12-312001-08-03Canada
Bev 29 TabTabletOralBeverly International Nutrition1987-12-311998-08-01Canada
Bev B-150TabletOralBeverly International Nutrition1986-12-311998-08-01Canada
Bio-fenCapsuleOralLisa & Gerry Freundl2001-10-102006-09-28Canada
BiosculptSolutionOralMaxion Nutrition Corp.2002-06-102004-07-20Canada
C-apnto-B6 Vitamins W Magnesium TabTabletOralMetagenics, Inc.1989-12-311996-10-02Canada
C-B ComplexTabletOralAvacare, Division Of Jeunique International Inc.1984-12-311996-09-09Canada
C.R.T. X Multivitamin & Mineral Powder MixPowderOralMetaform Ltd.1998-12-082001-07-23Canada
Carbassist TabletsTabletOralWyeth Ltd.1978-12-312006-07-24Canada
Cc IIPowderOralAdded Dimensions1997-03-262006-09-25Canada
Cda-21 Vitamins With Non-medicinal Probiotic ComplexCapsuleOralRx Vitamins Inc.2006-08-012007-10-25Canada
Cedevita Plus Vitamin SupplementPowderOralPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.Not applicableNot applicableCanada
Cedevita Sugar-free Vitamin SupplementPowderOralPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.Not applicableNot applicableCanada
Central-vite 18 EssentialTabletOralVita Health Products Inc1998-04-242002-07-31Canada
Century CompleteTabletOralVita Health Products Inc1998-03-172002-07-31Canada
Children Choice Multivit Chewable TabTabletOralSwiss Herbal Remedies Ltd.1990-12-312009-08-04Canada
Children Choice Multivitamin W Iron Chew TabTabletOralSwiss Herbal Remedies Ltd.1991-12-312009-08-04Canada
Children's Chewable Multi-vitamin Complete With MineralsTabletOralWn Pharmaceuticals Ltd.2000-03-012001-07-18Canada
Childrens Chewable Vitamin TabTabletOralPharmetics (2011) Inc.1993-12-312006-07-27Canada
Childrens Multiple Vit and Min Chew TabTabletOralCountry Health Laboratories Ltd.1982-12-312008-07-17Canada
Complete Mega BTabletOralGahler Enterprises Ltd.1985-12-312001-07-26Canada
Complete Multivitamins and Minerals for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
Complete Multivitamins and Minerals Tablets Timed ReleaseTablet, extended releaseOralPharmetics (2011) Inc.1999-07-262009-07-30Canada
Complex 5 - PwrPowderOralAst Research1996-03-151998-08-10Canada
Complex-75CapsuleOralFrega Inc.1990-12-311999-08-06Canada
Complexe B 75mgTabletOralPharmalab Inc.1994-12-312001-07-30Canada
Complexe B Compose 75TabletOralLes Laboratoires Bio SantÉ Inc.1983-12-311996-09-10Canada
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Concept DHACapsule, liquid filledOralUs Pharmaceutical Corporation2009-06-24Not applicableUs
Concept ObCapsuleOralUs Pharmaceutical Corporation2009-01-01Not applicableUs
D Pantothenic 500mg With 100mg CTabletOralGahler Enterprises Ltd.1986-12-312000-08-01Canada
D'pantothenic Acid-B1-B2 TabTabletOralHealth Thru Herbs Inc.1985-12-312001-06-21Canada
Daily Energy Brand B-complexCapsuleOralEnzymatic Therapy, Inc.2004-01-012008-07-25Canada
Derma-forceCapsuleOralPrairie Naturals1997-04-012006-09-20Canada
Dia-viteTabletOralR & D Laboratories Inc.1997-08-132003-07-16Canada
DiaplexTabletOralNephro Tech, Inc.2002-07-102004-07-23Canada
Dp 2000CapsuleOralPep Products Inc.1997-06-042006-08-23Canada
Efferlife Multivitamins and MineralsTablet, effervescentOralNaturale Science Inc.2001-10-012006-10-10Canada
Energy 80 Prolonged Release TabTablet, extended releaseOralSportscience Labs Inc.1981-12-312002-06-20Canada
Enviroflex - TabTabletOralEnviro Tech International Canada1997-09-151999-07-26Canada
EnviveCapsuleOralSisu Inc.2002-04-012006-07-31Canada
EscaviteTablet, chewableOralGm Pharmaceuticals2012-02-01Not applicableUs
Essential B TabletsTabletOralGeneral Nutrition Canada Inc.1997-04-182006-08-03Canada
Extra P.N. Vitamin-mineral Drink MixPowderOralChanges InternationalNot applicableNot applicableCanada
Fem - PmtTabletOralMetagenics, Inc.1998-02-252002-10-07Canada
Floriva PlusSolution / dropsOralBon Geo Pharmaceuticals, Inc.2015-12-28Not applicableUs
Formula 9 TabTabletOralPure Life International Prods Inc.1992-12-312001-08-07Canada
Formula Adr-vitamin B2,b6 W Calpan TabTabletOralMetagenics, Inc.1996-12-302006-08-14Canada
Formula CmTabletOralNutrivention Nutritional ProductsNot applicableNot applicableCanada
Formula D.S.TabletOralGolden Pride InternationalNot applicableNot applicableCanada
Formula Im-vitamins and Minerals TabTabletOralMetagenics, Inc.1997-01-272006-08-14Canada
Formula JsTabletOralNutrivention Nutritional ProductsNot applicableNot applicableCanada
Formula L.G.I.TabletOralMetagenics, Inc.1997-06-302002-10-07Canada
Formula LfTabletOralNumark Laboratories, Inc.2003-12-152009-07-31Canada
Formula Statin SupportCapsuleOralBalance Plus, Inc.2000-04-192004-08-17Canada
Fortamines 10 CapsulesCapsuleOralRougier Pharma Division Of Ratiopharm Inc1974-12-311999-09-27Canada
Fortamines-10 ComprimesTabletOralRougier Pharma Division Of Ratiopharm Inc1979-12-312003-09-22Canada
Fortistress TabTabletOralSantÉ Naturelle (Ag) LtÉe1993-12-312001-07-06Canada
Forty Plus Vitamin SupplementTabletOralGarden State Nutritionals1998-10-162000-06-07Canada
Fusion Activator Formula TabTabletOralL & S Research Corporation1993-12-311996-09-09Canada
Glyco-aide TabTabletOralAvant Garde, Les SupplÉments1995-12-311998-07-08Canada
Harvest Of Values All B Complex TabTabletOralHillestad Pharmaceuticals Usa1997-09-242009-09-22Canada
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Hi Potency B Complex W Chelated MineralsTabletOralKlaire Labs Inc.1984-12-312004-01-19Canada
Hi Potency B52 B Complex TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Hi Potency Balanced B-100 Complex - TabTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Hi Potency Stress B Tension With CTabletOralLee Adams Laboratories1982-12-312010-08-05Canada
High Potency Vitamin B Complex + C TabTabletOralVita Health Products Inc1996-10-112004-07-26Canada
Hill.viteTabletOralHillestad Pharmaceuticals Usa2001-11-142009-09-22Canada
Hypo Vites TabTabletOralPharmetics (2011) Inc.1977-12-312006-07-27Canada
Iberet 500Tablet, extended releaseOralAbbott1965-12-312007-07-31Canada
Insur-all Vitamin SupplementTabletOralGarden State Nutritionals1998-10-162000-06-07Canada
Integra PlusCapsuleOralUs Pharmaceutical Corporation2009-04-27Not applicableUs
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1996-07-232002-07-29Canada
Kanga Sport Vitamins B & C Plus MineralsTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-B Vitamin B Group + CTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-kid Multi-vitamin & MineralTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-V Multivitamins & MineralsTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kc Vitamin and Mineral SupplementLiquidOralMuscle Marketing Usa Inc.2001-02-242008-06-27Canada
Kenwood Liquid SupplementLiquidOralKenwood Laboratories (Division Of Bradley Pharmaceuticals)Not applicableNot applicableCanada
KindervitesSolution / dropsOralHerbalife International Of America1984-12-312002-09-17Canada
Leritone JuniorCapsuleOralInstitut De Recherche Biologique Yves Ponroy Canada Inc.1998-12-072004-12-23Canada
Lipo-B-C TabTabletOralMetagenics, Inc.1989-12-311996-10-02Canada
LipovitanLiquidOralP.S.W.C. Co., Inc.1999-01-212005-10-19Canada
Liqui B ComplexLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui B Complex PlusLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui Infant VitaminsLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui VitaLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liquid B Complex 50LiquidOralJamieson Laboratories Ltd1985-12-311997-08-13Canada
Livron Plus TabTabletOralMedic Laboratory LtÉe1980-12-311996-09-09Canada
Low Potency B Complex TabTabletOralFlora Manufacturing And Distributing Ltd.1983-12-311999-10-18Canada
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Maxi 10 TabTabletOralDesbergers LtÉe, Division Of Technilab Inc.1979-12-311999-09-17Canada
Mega 13 Multivitamin FormulaCapsuleOralVita Health Products Inc1988-12-311998-07-22Canada
Meplex T 750TabletOralMedic Laboratory LtÉe1966-12-311996-09-09Canada
Mini-B TabTabletOralTwin Laboratories Inc.1995-12-311999-11-10Canada
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Mr. Tumee Multi-vitaminTablet, chewableOralVitamec Usa2003-04-152006-09-29Canada
Multi - N.T.O.x Formula - TabTabletOralAbundance Naturally LtdNot applicableNot applicableCanada
Multi BTabletOralSeroyal International Inc.1988-12-312009-07-06Canada
Multi Nt-OXTabletOralAbundance Marketing Ltd.1999-02-012001-07-10Canada
Multi Vitamin - MineralTabletOralEnrich International1999-11-112001-09-28Canada
Multi Vitamin & MineralsTabletOralWn Pharmaceuticals Ltd.2002-01-042008-07-17Canada
Multi Vitamin-mineral FormulaTabletOralVita Health Products Inc1997-04-031998-01-16Canada
Multi Vitamines - LiqLiquidOralLand Art Inc.1995-12-312008-06-26Canada
Multi Vitamins & MineralsTabletOralWn Pharmaceuticals Ltd.2000-01-122001-04-12Canada
Multi-vitamin Dietary SupplementTabletOralGarden State Nutritionals1998-09-222000-06-07Canada
Multi-vitamines Enfants ComprimeTabletOralHerbes Universelles Inc.1997-09-292009-07-15Canada
Multi-vitamins With MineralsTabletOralWn Pharmaceuticals Ltd.2001-04-122009-09-28Canada
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Multiple Vitamins Plus Iron for WomenTabletOralPharmetics (2011) Inc.1999-08-162006-07-27Canada
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MultisolLiquidOralLes Laboratoires Vachon Inc.1979-12-311997-02-06Canada
Multivit-liqLiquidOralPharmalab Inc.1995-12-311997-08-08Canada
Multivitamines Et MinerauxTabletOralLe Groupe M. Vachon Inc.Not applicableNot applicableCanada
Multivitamines Et Mineraux Junior RegulierTabletOralLaboratoire Riva Inc1996-10-082008-07-30Canada
Multivitamines Et Mineraux Reguliers / Regular Multivitamins and MineralsTabletOralVita Health Products Inc1998-10-062004-07-26Canada
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Multivitamins and Multiminerals Formula Regular TabletTabletOralPharmetics (2011) Inc.2001-11-222009-07-30Canada
Myhephron Dialysis and Stress SupplementCapsuleOralMartin Ekwealor Pharmaceu2016-08-01Not applicableUs
Mynephrocaps Dialysis/stress Vitamin SupplementCapsuleOralMartin Ekwealor Pharmaceuticals, Inc.2013-12-16Not applicableUs
Nata KompleteTabletOralWh Nutritionals, Llc2011-06-252016-12-06Us
NephrocapsCapsule, liquid filledOralCardinal Health2010-01-14Not applicableUs
Nioxin Recharging ComplexCapsuleOralNioxin Research Laboratories, Inc.2002-06-192008-06-20Canada
Nutrilite Double XTabletOralNutrilite, A Division Of Access Business Group, Llc2002-12-152008-06-24Canada
Nutrol-B-complexTabletOralRolmex International Inc.1999-06-282008-07-09Canada
OnccorTabletOralSimone Protective Pharmaceuticals, Inc.Not applicableNot applicableCanada
One A Day Advance AdultsTabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance Adults 50+TabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance FemTabletOralBayer Inc Consumer Care1999-03-012001-02-22Canada
One A Day TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Original Bioscal Forte Multi-vitamin Supplement CapsulesCapsuleOralCarram Inc.1997-05-071999-07-30Canada
Orti BCapsuleOralSeroyal International Inc.1983-12-312008-10-09Canada
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PhytopureCapsuleOralLaboratoire Lalco Inc.1993-12-312001-10-15Canada
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Pnv Ferrous Fumarate Docusate Folic AcidTabletOralVirtus Pharmaceuticals2014-04-22Not applicableUs
Pnv-selectTablet, film coatedOralAcella Pharmaceuticals, LLC2009-11-02Not applicableUs
Polymine Avec Zinc Et CuivreTabletOralLes Laboratoires Vachon Inc.1985-12-312007-07-12Canada
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Preferaob Plus DHATabletOralAlaven Pharmaceutical2010-11-15Not applicableUs
PregvitTabletOralDuchesnay Inc.2003-08-252016-07-05Canada
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Pregvit Folic 5TabletOralDuchesnay Inc.2006-03-172016-07-05Canada
Prenatal 19Tablet, coatedOralNationwide Laboratories2013-06-01Not applicableUs
Prenatal Mega AntioxidantTabletOralUsana Health Services, Inc.2012-04-11Not applicableUs
Prenate EliteTablet, coatedOralAvion Pharmaceuticals, Llc2012-08-06Not applicableUs
Prenate StarTablet, coatedOralAvion Pharmaceuticals, Llc2014-06-05Not applicableUs
Purevit Dualfe PlusCapsuleOralPure Tek Corporation2011-06-01Not applicableUs
Q.T. Vitamin and Mineral Drink MixPowderOralGarden State NutritionalsNot applicableNot applicableCanada
Red American Eagle Vitamin Supplement DrinkLiquidOralP.S.W.C. Co., Inc.Not applicableNot applicableCanada
Red BullLiquidOralP.S.W.C. Co., Inc.1999-01-212005-10-19Canada
Reno CapsCapsuleOralNnodum Pharmaceuticals2008-11-30Not applicableUs63044 0622 01 nlmimage10 7d3cbea5
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Revit Plus CapCapsuleOralIcn Pharmaceuticals1972-12-311998-08-13Canada
Revival 1 TabTabletOralBio Vita1991-12-311999-08-12Canada
Right Choice A.M. Multi Formula - CapletTabletOralBody Wise International LlcNot applicableNot applicableCanada
Se-natal 19TabletOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-natal 19 ChewableTablet, chewableOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-natal OneTabletOralSeton Pharmaceuticals2009-04-162016-10-13Us
Se-tan PlusCapsule, gelatin coatedOralSeton Pharmaceuticals2009-10-01Not applicableUs
Shen Min Vitamin SupplementTabletOralBiotech Corporation2002-08-262007-06-25Canada
Sibergin B - CapCapsuleOralPharmavite1996-09-031998-09-08Canada
Snh FormulaCapsuleOralRegime Industries Ltd.2000-05-302008-07-10Canada
Somavit Brand Vitamins and Minerals ComplexTabletOralSoma Health Products2000-01-152005-08-26Canada
Sopalamine/3b Plus CTabletOralTechnilab Pharma Inc.1987-12-312001-09-05Canada
Spectra 301 Vitamin and Mineral SuppTabletOralNf Formulas Inc.1986-12-312000-07-05Canada
Spectrum 2 CapCapsuleOralNf Formulas Inc.1988-12-312008-06-26Canada
Stress B & C CapletTabletOralHealth Wise Nutrition Inc.1995-12-311998-08-25Canada
Stress B Capsules With Vitamin CCapsuleOralRheingold Food International Ltd.1987-12-312007-07-26Canada
Stress B Complex With C, E & IronTabletOralPharmavite1999-10-312005-07-15Canada
Stress B With 1000 Mg Vitamin CTabletOralHolista Health (Canada) Inc.2002-11-132008-07-17Canada
Stress B&c TabTabletOralBioforce Canada Inc.1985-12-311997-04-04Canada
Stress Complex 600 Avec Vit E Cuivre ZincTabletOralFrega Inc.1995-12-312008-02-13Canada
Stress Ctr SrtTablet, extended releaseOralBioenergy Inc.1979-12-311998-06-03Canada
Stress FormulaTabletOralVita Health Products Inc1998-05-202005-07-20Canada
Stress Formula + IronTabletOralVita Health Products Inc1998-05-202006-07-31Canada
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Stress Formula Multi-B Comp + 500mg Vit C CapCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Stress Formula Multivitamin Tablets USPTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Stress Formula TabTabletOralNatures Sunshine Products, Inc.1986-12-312009-09-09Canada
Stress Formula Vit B With C ComplexTabletOralWatkins Incorporated1985-12-312000-01-15Canada
Stress Forte Plus Lipotropic FactorsTabletOralDouglas Laboratories1995-12-312009-09-29Canada
Stress TabTabletOralVita Health Products Inc1981-12-312005-07-20Canada
Stress TabletsTabletOralD.C. Labs Limited1981-12-312003-07-11Canada
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StressmatesTabletOralTwin Laboratories Inc.1995-12-311999-11-10Canada
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Sun-rype VitaburstLiquidOralSun Rype Products Ltd.2004-08-102008-03-13Canada
Super B Compound W 500mg Vit CTabletOralGahler Enterprises Ltd.1986-12-312000-08-01Canada
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Super Daily No 2TabletOralW.R. Enterprises Inc.1990-12-312003-07-30Canada
Super PantoplexTabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Super Stress CapsulesCapsuleOralRheingold Food International Ltd.1987-12-311997-08-22Canada
Super Stress Mega B Plus 1000mg Vit C TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Super-cellCapsuleOralBody Wise International LlcNot applicableNot applicableCanada
Super-pote Vitamin SupplementTabletOralGarden State Nutritionals1998-09-252000-06-07Canada
Supplement De Multivitamines Infusion Arome Fruits RougesKitOralYves Rocher Inc.1999-10-182000-08-08Canada
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Supravite Stress Avec Vit E Cuivre Et ZincTabletOralPharmalab Inc.1985-12-311997-08-08Canada
Supravite Stress Avec Vit E Et FerTabletOralPharmalab Inc.1985-12-311997-08-08Canada
Surbex 500 FilmtabTabletOralAbbott1979-12-312008-06-06Canada
Surbex-500 With IronTabletOralAbbott1986-12-312008-06-06Canada
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T.R.I. B-plex SrcCapsule, extended releaseOralAnabolic Laboratories Inc.1979-12-312004-03-15Canada
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Tandem PlusCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tar-endCapsuleOralNatures Sunshine Products, Inc.1999-05-252006-07-10Canada
Time Release B 100 Compound - TabletTabletOralHealth Wise Nutrition Inc.1996-10-222002-07-18Canada
Timed Release B Complex 100 SrtTablet, extended releaseOralJamieson Laboratories Ltd1994-12-311997-08-13Canada
Timed Release B-complex 100Tablet, extended releaseOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Timed Release B-complex 50Tablet, extended releaseOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Toni Com LiqLiquidOralVitalab1990-12-312009-07-14Canada
Tri AdrenopanCapsule, extended releaseOralAnabolic Laboratories Inc.1980-12-312004-03-15Canada
Trinatal GtTabletOralTrigen Laboratories, Inc.2011-07-05Not applicableUs
Twin Ultra Liquid Fruit Punch FlavorLiquidOralTwin Laboratories Inc.1995-12-312002-09-11Canada
Twin Ultra Liquid Grape FlavorLiquidOralTwin Laboratories Inc.1995-12-312007-08-01Canada
Twin Ultra Liquid Lemon-lime FlavorLiquidOralTwin Laboratories Inc.1995-12-312005-08-30Canada
Twin Ultra Liquid Orange FlavorLiquidOralTwin Laboratories Inc.1995-12-312002-09-11Canada
Ultra EnerforceLiquidOralNutribon (1986) Inc.2002-01-292005-02-16Canada
Ultra HrTabletOralNatural Organics Inc.Not applicableNot applicableCanada
Usana Megavitamin Tablets - TabTabletOralUsana Health Sciences, Inc.1996-12-302000-09-11Canada
Vasodyn TabTabletOralNutri Dyn Products Ltd.1978-12-311998-08-13Canada
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Vit B Complex CtrTablet, extended releaseOralBioenergy Inc.1979-12-311998-06-03Canada
Vit B Complex Plus Vit C 550mgCapsuleOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
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Vitabanks Vitamin TabTabletOralVitabank Inc.1990-12-311997-05-30Canada
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Vitogen B Stress C600TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1981-12-312002-07-31Canada
Vitreat Chewable Vitamin TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1972-12-311997-08-08Canada
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VP-heme OBTablet, film coatedOralVirtus Pharmaceuticals2013-10-14Not applicableUs
VP-heme OneCapsule, gelatin coatedOralVirtus Pharmaceuticals2013-03-01Not applicableUs
Vtb Vitamin and Mineral SupplementTabletOralGarden State NutritionalsNot applicableNot applicableCanada
Women's FormulaTabletOralPro Ma Systems1998-10-312007-09-25Canada
Categories
UNII19F5HK2737
CAS number79-83-4
WeightAverage: 219.235
Monoisotopic: 219.110672659
Chemical FormulaC9H17NO5
InChI KeyGHOKWGTUZJEAQD-UHFFFAOYSA-N
InChI
InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13)
IUPAC Name
3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoic acid
SMILES
CC(C)(CO)C(O)C(=O)NCCC(O)=O
Pharmacology
Indication

Studied for the treatment of many uses such as treatment of testicular torsion, diabetic ulceration, wound healing, acne, obesity, diabetic peripheral polyneuropathy. It has also been investigated for its hypolipidemic effects and as cholesterol lowering agent.

Structured Indications Not Available
Pharmacodynamics

Pantothenic acid is used in the synthesis of coenzyme A (CoA). Coenzyme A may act as an acyl group carrier to form acetyl-CoA and other related compounds; this is a way to transport carbon atoms within the cell. CoA is important in energy metabolism for pyruvate to enter the tricarboxylic acid cycle (TCA cycle) as acetyl-CoA, and for α-ketoglutarate to be transformed to succinyl-CoA in the cycle. CoA is also important in the biosynthesis of many important compounds such as fatty acids, cholesterol, and acetylcholine. CoA is incidentally also required in the formation of ACP, which is also required for fatty acid synthesis in addition to CoA.

Pantothenic acid in the form of CoA is also required for acylation and acetylation, which, for example, are involved in signal transduction and enzyme activation and deactivation, respectively.

Since pantothenic acid participates in a wide array of key biological roles, it is essential to all forms of life. As such, deficiencies in pantothenic acid may have numerous wide-ranging effects, as discussed below.

Mechanism of action

Pantothenic acid is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.

TargetKindPharmacological actionActionsOrganismUniProt ID
Pantothenate kinaseProteinunknownNot AvailableEscherichia coli (strain K12)P0A6I3 details
Related Articles
Absorption

When found in foods, most pantothenic acid is in the form of CoA or acyl carrier protein (ACP). For the intestinal cells to absorb this vitamin, it must be converted into free pantothenic acid. Within the lumen of the intestine, CoA and ACP are hydrolyzed into 4'-phosphopantetheine. The 4'-phosphopantetheine is then dephosphorylated into pantetheine. Pantetheinase, an intestinal enzyme, then hydrolyzes pantetheine into free pantothenic acid. Free pantothenic acid is absorbed into intestinal cells via a saturable, sodium-dependent active transport system. At high levels of intake, when this mechanism is saturated, some pantothenic acid may also be absorbed via passive diffusion. As intake increases 10-fold, however, absorption rate decreases to 10%. [Wikipedia]

Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
Toxicity

No Tolerable Upper Level Intake (UL) has been established for the vitamin.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Carnosinuria, carnosinemiaDiseaseSMP00493
Beta-Alanine MetabolismMetabolicSMP00007
Pantothenate and CoA BiosynthesisMetabolicSMP00027
GABA-Transaminase DeficiencyDiseaseSMP00351
Ureidopropionase deficiencyDiseaseSMP00492
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions Not Available
Food InteractionsNot Available
References
Synthesis Reference

John F. Verbeeck, "Process for the production of the calcium salt of pantothenic acid." U.S. Patent US3935256, issued February, 1971.

US3935256
General References
  1. Trumbo, P. R. (2005). Pantothenic Acid. In Modern Nutrition in Health and Disease (10th ed., pp. 462–467). Lippincott Williams & Wilkins. [ISBN:0-7817-4133-5 ]
External Links
ATC CodesD03AX04 — Calcium pantothenateA11HA31 — Calcium pantothenate
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSDownload (47.9 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentDiabetic Peripheral Neuropathic Pain1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentPregnancy1
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
TabletOral1 g
ElixirOral
SolutionOral
PowderOral
Capsule, liquid filledOral
CapsuleOral
CapsuleOral250 mg
Tablet, extended releaseOral1 g
Tablet, effervescentOral
Tablet, extended releaseOral
Solution / dropsOral
LiquidIntravenous
Tablet, chewableOral
TabletOral250 mg
TabletOral500 mg
CapsuleOral500 mg
CapsuleOral100 mg
TabletOral100 mg
TabletOral200 mg
Tablet, extended releaseOral500 mg
TabletOral300 mg
Tablet, coatedOral
Capsule, gelatin coatedOral
TabletOral
KitOral
Capsule, extended releaseOral
LiquidOral
CapsuleOral300 mg
TabletOral50 mg
Tablet, film coatedOral
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)195ºC (D-Calcium Pantothenate salt)MSDS
water solubilitySolubleMSDS
Predicted Properties
PropertyValueSource
Water Solubility60.5 mg/mLALOGPS
logP-1.1ALOGPS
logP-1.4ChemAxon
logS-0.56ALOGPS
pKa (Strongest Acidic)4.35ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area106.86 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity51.51 m3·mol-1ChemAxon
Polarizability21.92 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.6189
Blood Brain Barrier+0.6889
Caco-2 permeable-0.7055
P-glycoprotein substrateSubstrate0.5464
P-glycoprotein inhibitor INon-inhibitor0.836
P-glycoprotein inhibitor IINon-inhibitor0.9184
Renal organic cation transporterNon-inhibitor0.95
CYP450 2C9 substrateNon-substrate0.8235
CYP450 2D6 substrateNon-substrate0.8051
CYP450 3A4 substrateNon-substrate0.5411
CYP450 1A2 substrateNon-inhibitor0.9133
CYP450 2C9 inhibitorNon-inhibitor0.9137
CYP450 2D6 inhibitorNon-inhibitor0.9417
CYP450 2C19 inhibitorNon-inhibitor0.8929
CYP450 3A4 inhibitorNon-inhibitor0.9587
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9305
Ames testNon AMES toxic0.9278
CarcinogenicityNon-carcinogens0.9062
BiodegradationReady biodegradable0.662
Rat acute toxicity1.7394 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9968
hERG inhibition (predictor II)Non-inhibitor0.944
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-014i-3190000000-7a9e1fb7ca94ff4714e8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-00dl-9100000000-ada04a866c6d38235607View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0596-9000000000-aea14dc63426efd5a60dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,1H] 2D NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as beta amino acids and derivatives. These are amino acids having a (-NH2) group attached to the beta carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentBeta amino acids and derivatives
Alternative ParentsN-acyl amines / Monosaccharides / Secondary carboxylic acid amides / Secondary alcohols / Monocarboxylic acids and derivatives / Carboxylic acids / Primary alcohols / Organopnictogen compounds / Organonitrogen compounds / Organic oxides
SubstituentsBeta amino acid or derivatives / Fatty amide / Monosaccharide / N-acyl-amine / Fatty acyl / Carboxamide group / Secondary carboxylic acid amide / Secondary alcohol / Carboxylic acid / Monocarboxylic acid or derivatives
Molecular FrameworkAliphatic acyclic compounds
External Descriptorspantothenic acids (CHEBI:7916 )

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Pantothenate kinase activity
Specific Function:
Not Available
Gene Name:
coaA
Uniprot ID:
P0A6I3
Uniprot Name:
Pantothenate kinase
Molecular Weight:
36359.435 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Drug created on June 13, 2005 07:24 / Updated on August 02, 2017 16:36