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Identification
NamePantothenic acid
Accession NumberDB01783  (EXPT02501)
TypeSmall Molecule
GroupsNutraceutical, Vet Approved
DescriptionPantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. For many animals, pantothenic acid is an essential nutrient. Animals require pantothenic acid to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. Pantothenic acid is the amide between pantoic acid and β-alanine. Small quantities of pantothenic acid are found in nearly every food, with high amounts in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. It is commonly found as its alcohol analog, the provitamin panthenol, and as calcium pantothenate. Pantothenic acid is an ingredient in some hair and skin care products. Only the dextrorotatory (D) isomer of pantothenic acid possesses biologic activity. The levorotatory (L) form may antagonize the effects of the dextrorotatory isomer. [Wikipedia]
Structure
Thumb
Synonyms
(+)-Pantothenic acid
D-pantothenic acid
Pantothenate
Vitamin B5
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acti Pantothenic Acid 1000 Timed CapletTablet1 gOralActi Form Ltd.1991-12-312005-03-21Canada
Acti-pantothenic Acid 300 Caplet 300mgTablet300 mgOralActi Form Ltd.1991-12-312005-03-21Canada
Calcium Pantothenate Tab 250mgTablet250 mgOralTrophic Canada Ltd.1991-12-311996-09-17Canada
Calpan Tab 100mgTablet100 mgOralIcn Canada Ltd.1973-12-311998-08-13Canada
Calpan Tab 250mgTablet250 mgOralIcn Canada Ltd.1973-12-311998-08-13Canada
D Pantothenic Acid Tab 100mgTablet100 mgOralGahler Enterprises Ltd.1984-12-312000-08-01Canada
D-pantothenic Acid 250mgCapsule250 mgOralWn Pharmaceuticals Ltd.2001-10-072007-08-07Canada
D-pantothenic Acid 250mg CapCapsule250 mgOralGahler Enterprises Ltd.1993-12-312008-07-17Canada
D'pantothenic Acid Srt 1000mgTablet, extended release1 gOralGahler Enterprises Ltd.1981-12-312001-07-26Canada
Pantacid Tab 250mgTablet250 mgOralLes Produits Naturels Suisse Inc.1985-12-311996-09-09Canada
Pantothenic AcidCapsule250 mgOralSeroyal International Inc.1993-12-312008-10-09Canada
Pantothenic Acid 100 Mg TabletsTablet100 mgOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
Pantothenic Acid 100mgTablet100 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Pantothenic Acid 250mgTablet250 mgOralGeneral Nutrition Canada Inc.1997-08-132005-08-05Canada
Pantothenic Acid 250mgTablet250 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Pantothenic Acid 500 Caplet 500mgTablet500 mgOralHealth Wise Nutrition Inc.1994-12-311998-08-25Canada
Pantothenic Acid 500 mgCapsule500 mgOralFlora Manufacturing And Distributing Ltd.2002-03-152007-08-03Canada
Pantothenic Acid 500mgTablet500 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Pantothenic Acid Cap 250mgCapsule250 mgOralQuest Vitamins A Div Of Purity Life Health Products1980-12-312001-07-06Canada
Pantothenic Acid Caps 100mgCapsule100 mgOralTwin Laboratories Inc.1995-12-312002-09-11Canada
Pantothenic Acid Caps 250mgCapsule250 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Pantothenic Acid Ctr Srt 500mgTablet, extended release500 mgOralBioenergy Inc.1979-12-311998-06-03Canada
Pantothenic Acid Tab 100mgTablet100 mgOralVita Health Products Inc1976-12-312002-07-31Canada
Pantothenic Acid Tab 100mg Nu LifeTablet100 mgOralNu Life Nutrition Ltd.1964-12-312000-03-03Canada
Pantothenic Acid Tab 200mgTablet200 mgOralKlaire Labs Inc.1984-12-311999-01-18Canada
Pantothenic Acid Tab 250mgTablet250 mgOralNutri West Products Ltd.1991-12-312002-06-14Canada
Pantothenic Acid Tab 500mgTablet, extended release500 mgOralPure Life International Prods Inc.1992-12-312001-08-07Canada
Pantothenic Acid Tablets 300mgTablet300 mgOralNu Life Nutrition Ltd.1986-12-312005-03-15Canada
Pantothenic Acid-S Tab 100mgTablet100 mgOralNutri West Products Ltd.1993-12-311997-08-05Canada
Vita-tenic Cap 300mgCapsule300 mgOralLes Laboratoires Vachon Inc.1989-12-311997-02-06Canada
Vitamin B5 (pantothenic Acid) Tab 250mgTablet250 mgOralJamieson Laboratories Ltd1993-12-312001-09-14Canada
Vitamin B5 Tab 50mg USP ChewableTablet50 mgOralLab Gernetic Int Ltee1986-12-311997-02-21Canada
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Adrenergy TabletsMorter Healthsystem
Adrenogist TabPure Life International Prods Inc.
Advanced 2000 CapsulesBody Gold, A Division Of Pep Products, Inc.
Allbee With C 550 CapWhitehall Robins Inc.
Allbee With Vitamin C CapWhitehall Robins Inc.
American Eagle Energizer Plus Vitamin Supplement DrinkP.S.W.C. Co., Inc.
American Plus Energy & Vitamin DrinkP.S.W.C. Co., Inc.
ArmaxEnzymatic Therapy (Canada) Inc.
B 50 CapsulesRheingold Food International Ltd.
B C Antistress CapLes Laboratoires Bio SantÉ Inc.
B Complex 25mg Vitamin SupplementGarden State Nutritionals
B Complex 50 Vitamin CapBioforce Canada Inc.
B Complex 50+ CapletHealth Wise Nutrition Inc.
B Complex 500 TabNobel Pharm Enr.
B Complex Plus C 300mg TabNutricorp International
B Complex TabletsGolden Neo Life Diamite International, Limited
B Complex W C Forte CapEverest Pharmaceuticals Ltd.
B Complex W Vit C W Non-med Yeast&liver TabPharmavite Llc
B Complex W Vitamin C Fortis CapShoppers Drug Mart Inc.
B Complex With C 300mgVita Health Products Inc
B Complex With C 300mg TabPharmavite Llc
B Complex With C 550mgVita Health Products Inc
B Compound 50mg TabGahler Enterprises Ltd.
B Plus C 300 mgVita Health Products Inc
B Plus C 300mg Timed ReleaseVita Health Products Inc
B Stress C + Iron & ViteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
B Totum 500Desbergers LtÉe, Division Of Technilab Inc.
B VirolRolmex International Inc.
B With C 500 CapPharmetics (2011) Inc
B-100 CapsNow Foods
B-100 Complex TabletsViva Pharmaceutical Inc.
B-100 Hi Potency B Vitamins TabNatrol, Inc.
B-100 Vitamin SupplementGarden State Nutritionals
B-50 ComplexVita Health Products Inc
B-50 Complex TabVita Health Products Inc
B-50 Hi Potency B Vitamins TabNatrol, Inc.
B-complexEnrich International
B-complex 100Great Earth Companies, Inc.
B-complex 50Great Earth Companies, Inc.
B-complex TabNature's Sunshine Products Of Canada Ltd.
B-complex TabletsShaklee Canada Inc
B-complex With Vitamin C, Biotin, Folic AcidWn Pharmaceuticals Ltd.
B-complex-50 TabJr Carlson Labs Inc
B-plexWn Pharmaceuticals Ltd.
B-plus - TabChampion's Choice Advanced Nutrition Inc.
B50 B Complex TabNutristar Health Products (1987) Inc.
B50 ComplexPreferred Nutrition Inc.
BacminMarnel Pharmaceuticals, Inc.
Balanced B 125 SrtAnabolic Laboratories Inc.
Balanced B-100 B-complex Vitamins TabPharmavite Llc
Balanced B-100 Timed ReleasePharmavite Llc
Balanced B-50 B-complex Vitamins TabPharmavite Llc
Balanced B-50 B-complex Vitamins, Timed RelePharmavite Llc
Balanced B-50 ComplexLeiner Health Products Inc.
Balanced B-complex Vit + Vit C&e TabPharmavite Llc
Balanced B100Hall Laboratories, Ltd.
Balanced B50 ComplexHall Laboratories, Ltd.
Beminal With C Fortis CapWyeth Ayerst Canada Inc.
Bev 29 TabBeverly International Nutrition
Bev B-150Beverly International Nutrition
Bio-fenLisa & Gerry Freundl
C-apnto-B6 Vitamins W Magnesium TabMetagenics, Inc.
C-B ComplexAvacare, Division Of Jeunique International Inc.
C.R.T. X Multivitamin & Mineral Powder MixMetaform Ltd.
Carbassist TabletsWyeth Consumer Healthcare Inc.
Cc IIAdded Dimensions
Cda-21 Vitamins With Non-medicinal Probiotic ComplexRx Vitamins Inc.
Cedevita Plus Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cedevita Sugar-free Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Children Choice Multivit Chewable TabSwiss Herbal Remedies Ltd.
Children Choice Multivitamin W Iron Chew TabSwiss Herbal Remedies Ltd.
Children's Chewable Multi-vitamin Complete With MineralsWn Pharmaceuticals Ltd.
Childrens Chewable Vitamin TabPharmetics (2011) Inc
Childrens Multiple Vit and Min Chew TabCountry Health Laboratories Ltd.
Complete Mega BGahler Enterprises Ltd.
Complete Multivitamins and Minerals Tablets Timed ReleasePharmetics (2011) Inc
Complex 5 - PwrAst Research
Complex-75Frega Inc.
Complexe B 75mgPharmalab Inc.
Complexe B Compose 75Les Laboratoires Bio SantÉ Inc.
Complexe B-75Frega Inc.
Concept DHAUs Pharmaceutical Corporation
Concept ObUs Pharmaceutical Corporation
D Pantothenic 500mg With 100mg CGahler Enterprises Ltd.
D'pantothenic Acid-B1-B2 TabHealth Thru Herbs Inc.
Daily Energy Brand B-complexEnzymatic Therapy (Canada) Inc.
Derma-forcePrairie Naturals
Dia-viteR & D Laboratories Inc.
DiaplexNephro Tech, Inc.
Dp 2000Pep Products Inc.
Efferlife Multivitamins and MineralsNaturale Science Inc.
Energy 80 Prolonged Release TabSportscience Labs Inc.
Enviroflex - TabEnviro Tech International Canada
EnviveSisu Inc.
EscaviteGm Pharmaceuticals, Inc.
Essential B TabletsGeneral Nutrition Canada Inc.
Extra P.N. Vitamin-mineral Drink MixChanges International
Fem - PmtMetagenics, Inc.
Floriva PlusBon Geo Pharmaceuticals, Inc.
Formula 9 TabPure Life International Prods Inc.
Formula Adr-vitamin B2,b6 W Calpan TabMetagenics, Inc.
Formula CmNutrivention Nutritional Products
Formula D.S.Golden Pride International
Formula Im-vitamins and Minerals TabMetagenics, Inc.
Formula JsNutrivention Nutritional Products
Formula L.G.I.Metagenics, Inc.
Formula LfNumark Laboratories, Inc.
Fortamines 10 CapsulesRougier Pharma Division Of Ratiopharm Inc
Fortamines-10 ComprimesRougier Pharma Division Of Ratiopharm Inc
Fortistress TabSantÉ Naturelle (Ag) LtÉe
Forty Plus Vitamin SupplementGarden State Nutritionals
Fusion Activator Formula TabL & S Research Corporation
Glyco-aide TabAvant Garde, Les SupplÉments
Harvest Of Values All B Complex TabHillestad Pharmaceuticals Usa
Healthy Mamabe Well Rounded Be Well RoundedMATERNAL SCIENCE, LLC
Hemarexin TabLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hemenatal OBWh Nutritionals, Llc
Hi Potency B Complex W Chelated MineralsKlaire Labs Inc.
Hi Potency B52 B Complex TabCountry Health Laboratories Ltd.
Hi Potency Balanced B-100 Complex - TabLeiner Health Products Inc.
Hi Potency Stress B Tension With CLee Adams Laboratories
High Potency Vitamin B Complex + C TabVita Health Products Inc
Hill.viteHillestad Pharmaceuticals Usa
Hypo Vites TabPharmetics (2011) Inc
Iberet 500Abbott Laboratories, Limited
Insur-all Vitamin SupplementGarden State Nutritionals
Integra PlusUs Pharmaceutical Corporation
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoQuest Vitamins A Div Of Purity Life Health Products
Kanga Sport Vitamins B & C Plus MineralsLacombe Drugs (1992) Ltd
Kanga-B Vitamin B Group + CLacombe Drugs (1992) Ltd
Kanga-kid Multi-vitamin & MineralLacombe Drugs (1992) Ltd
Kanga-V Multivitamins & MineralsLacombe Drugs (1992) Ltd
Kc Vitamin and Mineral SupplementMuscle Marketing Usa Inc.
Kenwood Liquid SupplementKenwood Laboratories (Division Of Bradley Pharmaceuticals)
KindervitesHerbalife International Of America, Inc.
Leritone JuniorInstitut De Recherche Biologique Yves Ponroy Canada Inc.
Lipo-B-C TabMetagenics, Inc.
LipovitanP.S.W.C. Co., Inc.
Liqui B ComplexTwin Laboratories Inc.
Liqui B Complex PlusTwin Laboratories Inc.
Liqui Infant VitaminsTwin Laboratories Inc.
Liqui VitaTwin Laboratories Inc.
Liquid B Complex 50Jamieson Laboratories Ltd
Livron Plus TabMedic Laboratory LtÉe
Low Potency B Complex TabFlora Manufacturing And Distributing Ltd.
M.V.I. PaediatricAventis Pharma Inc
Maxi 10 TabDesbergers LtÉe, Division Of Technilab Inc.
Mega 13 Multivitamin FormulaVita Health Products Inc
Meplex T 750Medic Laboratory LtÉe
Mini-B TabTwin Laboratories Inc.
Mor-vites TabPharmetics (2011) Inc
Mr. Tumee Multi-vitaminVitamec Usa
Multi - N.T.O.x Formula - TabAbundance Marketing Ltd.
Multi BSeroyal International Inc.
Multi Nt-OXAbundance Marketing Ltd.
Multi Vitamin - MineralEnrich International
Multi Vitamin & MineralsWn Pharmaceuticals Ltd.
Multi Vitamin-mineral FormulaVita Health Products Inc
Multi Vitamines - LiqLand Art Inc.
Multi Vitamins & MineralsWn Pharmaceuticals Ltd.
Multi-vitamin Dietary SupplementGarden State Nutritionals
Multi-vitamines Enfants ComprimeHerbes Universelles Inc.
Multi-vitamins With MineralsWn Pharmaceuticals Ltd.
Multiple Vitamin Plus Minerals TabHall Laboratories, Ltd.
Multiple Vitamins and Minerals TabRandle Labs Inc.
Multiple Vitamins Plus Iron for WomenPharmetics (2011) Inc
Multiple Vitamins W Minerals TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins With Minerals TabletsPharmetics (2011) Inc
MultisolLes Laboratoires Vachon Inc.
Multivit-liqPharmalab Inc.
Multivitamines Et MinerauxLe Groupe M. Vachon Inc.
Myhephron Dialysis and Stress SupplementMartin Ekwealor Pharmaceu
Mynephrocaps Dialysis/stress Vitamin SupplementMartin Ekwealor Pharmaceuticals, Inc.
Nata KompleteWh Nutritionals, Llc
NephrocapsCardinal Health
Nioxin Recharging ComplexNioxin Research Laboratories, Inc.
Nutrilite Double XNutrilite, A Division Of Access Business Group, Llc
Nutrol-B-complexRolmex International Inc.
OnccorSimone Protective Pharmaceuticals, Inc.
One A Day Advance AdultsBayer Inc Consumer Care
One A Day Advance Adults 50+Bayer Inc Consumer Care
One A Day Advance FemBayer Inc Consumer Care
One A Day TabCountry Health Laboratories Ltd.
Original Bioscal Forte Multi-vitamin Supplement CapsulesCarram Inc.
Orti BSeroyal International Inc.
P.N.P. Vitamin DrinkChanges International
Phosthenine Vitamines Et Fer (ampoules Buvable)Laboratoires Cortunon Inc.
PhytopureLaboratoire Lalco Inc.
PM CapsNew Vision Nutritionals Company
Pnv Ferrous Fumarate Docusate Folic AcidVirtus Pharmaceuticals LLC
Pnv-selectAcella Pharmaceuticals, LLC
Polymine Avec Zinc Et CuivreLes Laboratoires Vachon Inc.
Prefera Ob Plus DHAAlaven Pharmaceutical LLC
PreferaobMEDA Pharmaceuticals
Preferaob OneMEDA Pharmaceuticals
Preferaob Plus DHAAlaven Pharmaceutical LLC
PregvitDuchesnay Inc
Pregvit Folic 4Duchesnay Inc
Pregvit Folic 5Duchesnay Inc
Prenatal 19Nationwide Laboratories, LLC
Prenatal Mega AntioxidantUsana Health Services, Inc.
Prenate EliteAvion Pharmaceuticals, Llc
Prenate StarAvion Pharmaceuticals, Llc
Purevit Dualfe PlusPure Tek Corporation
Q.T. Vitamin and Mineral Drink MixGarden State Nutritionals
Red American Eagle Vitamin Supplement DrinkP.S.W.C. Co., Inc.
Red BullP.S.W.C. Co., Inc.
Reno CapsNnodum Pharmaceuticals
ReplaviteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Revit Plus CapIcn Canada Ltd.
Revival 1 TabBio Vita
Right Choice A.M. Multi Formula - CapletBody Wise International Llc
Se-natal 19Seton Pharmaceuticals
Se-natal 19 ChewableSeton Pharmaceuticals
Se-natal OneSeton Pharmaceuticals
Se-tan PlusSeton Pharmaceuticals
Shen Min Vitamin SupplementBiotech Corporation
Sibergin B - CapPharmavite Llc
Snh FormulaRegime Industries Ltd.
Somavit Brand Vitamins and Minerals ComplexSoma Health Products
Sopalamine/3b Plus CTechnilab Pharma Inc.
Spectra 301 Vitamin and Mineral SuppNf Formulas Inc.
Spectrum 2 CapNf Formulas Inc.
Stress B & C CapletHealth Wise Nutrition Inc.
Stress B Capsules With Vitamin CRheingold Food International Ltd.
Stress B Complex With C, E & IronPharmavite Llc
Stress B With 1000 Mg Vitamin CHolista Health (Canada) Inc.
Stress B&c TabBioforce Canada Inc.
Stress Complex 600 Avec Vit E Cuivre ZincFrega Inc.
Stress Ctr SrtBioenergy Inc.
Stress FormulaVita Health Products Inc
Stress Formula + IronVita Health Products Inc
Stress Formula B-comp + 500mg Vit C TabQuest Vitamins A Div Of Purity Life Health Products
Stress Formula Multi-B Comp + 500mg Vit C CapQuest Vitamins A Div Of Purity Life Health Products
Stress Formula Multivitamin Tablets USPLeiner Health Products Inc.
Stress Formula TabNature's Sunshine Products Of Canada Ltd.
Stress Formula Vit B With C ComplexWatkins Incorporated
Stress Forte Plus Lipotropic FactorsDouglas Laboratories
Stress TabVita Health Products Inc
Stress TabletsD.C. Labs Limited
Stress Vitamin B With C Complex TabletsPurity Life Health Products A Division Of Sunopta Inc.
StressmatesTwin Laboratories Inc.
Strovite Forte CapletEverett Laboratories, Inc.
Strovite One CapletsEverett Laboratories, Inc.
Sun-rype VitaburstSun Rype Products Ltd.
Super B Compound W 500mg Vit CGahler Enterprises Ltd.
Super Charged EnergySimone Protective Pharmaceuticals, Inc.
Super Daily No 2W.R. Enterprises Inc.
Super PantoplexNu Life Nutrition Ltd.
Super Stress CapsulesRheingold Food International Ltd.
Super Stress Mega B Plus 1000mg Vit C TabQuest Vitamins A Div Of Purity Life Health Products
Super-cellBody Wise International Llc
Super-pote Vitamin SupplementGarden State Nutritionals
Supplement De Multivitamines Infusion Arome Fruits RougesYves Rocher Inc.
Supravite Bouteille 250mlNobel Pharm Enr.
Supravite Stress Avec Vit EPharmalab Inc.
Supravite Stress Avec Vit E Cuivre Et ZincPharmalab Inc.
Supravite Stress Avec Vit E Et FerPharmalab Inc.
Surbex 500 FilmtabAbbott Laboratories, Limited
Surbex-500 With IronAbbott Laboratories, Limited
Surbex-500 With ZincAbbott Laboratories, Limited
Swical-energy-2Les Laboratoires Swisse Inc.
T.R.I. B-plex SrcAnabolic Laboratories Inc.
Tandem ObUs Pharmaceutical Corporation
Tandem PlusUs Pharmaceutical Corporation
Tar-endNature's Sunshine Products Inc.
Time Release B 100 Compound - TabletHealth Wise Nutrition Inc.
Timed Release B Complex 100 SrtJamieson Laboratories Ltd
Timed Release B-complex 100Great Earth Companies, Inc.
Timed Release B-complex 50Great Earth Companies, Inc.
Toni Com LiqVitalab
Tri AdrenopanAnabolic Laboratories Inc.
Trinatal GtTrigen Laboratories, Inc.
Twin Ultra Liquid Fruit Punch FlavorTwin Laboratories Inc.
Twin Ultra Liquid Grape FlavorTwin Laboratories Inc.
Twin Ultra Liquid Lemon-lime FlavorTwin Laboratories Inc.
Twin Ultra Liquid Orange FlavorTwin Laboratories Inc.
Ultra EnerforceNutribon (1986) Inc.
Ultra HrNatural Organics Inc.
Usana Megavitamin Tablets - TabUsana Health Sciences Inc.
Vasodyn TabNutri Dyn Products Ltd.
Virt-capsVirtus Pharmaceuticals LLC
Virt-PNVirtus Pharmaceuticals
Virt-vite PlusVirtus Pharmaceuticals LLC
Vit B Complex CtrBioenergy Inc.
Vit B Complex Plus Vit C 550mgHall Laboratories, Ltd.
Vit-HA Multi Vitamin and Zinc SupplementRheingold Food International Ltd.
Vita B + C 500 TabLaboratoire Romilo
Vita B Complex TabNutrimetics International (Canada) Inc.
Vita-BNutri Dyn Products Ltd.
Vita-B-75 CapLes Laboratoires Vachon Inc.
Vita-worth B-complex TabletsGeneral Nutrition Canada Inc.
Vitabanks Vitamin TabVitabank Inc.
Vitaflex Dietary SuplementHome Shopping Network Direct
Vitalife - CapsuleHolista Health (Canada) Inc.
Vitamin B + C CapFinlandia Consultants
Vitamin B Complex + C 300mg CapRandle Labs Inc.
Vitamin B Complex + C 600mg TabRandle Labs Inc.
Vitamin B Complex 100 TabBioforce Canada Inc.
Vitamin B Complex 50Gfr Pharma Ltd.
Vitamin B Complex Plus 300mg Vitamin CHall Laboratories, Ltd.
Vitamin B Complex Plus C 300mg Timed ReleaseVita Health Products Inc
Vitamin B Complex SupplAvacare, Division Of Jeunique International Inc.
Vitamin B Complex TabNutristar Health Products (1987) Inc.
Vitamin B Complex W C 300mg TabLee Adams Laboratories
Vitamin B Complex W C TabAlbi Imports Ltd.
Vitamin B Compound TabNutrilite, A Division Of Access Business Group, Llc
Vitamin B Compound W C Tab 500mgAdams Labs Ltd.
Vitamin B Compound W Vit C 250mg TabSwiss Herbal Remedies Ltd.
Vitamin B Compound With Vitamin C Fortis Capsule DtcD.C. Labs Limited
Vitamin B Cpd W Vit C TabIcn Canada Ltd.
Vitamin B TabletsWeider Health Products
Vitamine 110 LiqFrega Inc.
Vitamins ChewableStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vitamins W Iron ChewableStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vitogen B Stress C Vit E Zinc & CopStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vitogen B Stress C600Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.
VP-heme OBVirtus Pharmaceuticals LLC
VP-heme OneVirtus Pharmaceuticals LLC
Vtb Vitamin and Mineral SupplementGarden State Nutritionals
Women's FormulaPro Ma Systems
Salts
Name/CASStructureProperties
Calcium pantothenate
137-08-6
Thumb
  • InChI Key: FAPWYRCQGJNNSJ-UBKPKTQASA-L
  • Monoisotopic Mass: 476.168286409
  • Average Mass: 476.532
DBSALT000034
Categories
UNII19F5HK2737
CAS number79-83-4
WeightAverage: 219.235
Monoisotopic: 219.110672659
Chemical FormulaC9H17NO5
InChI KeyGHOKWGTUZJEAQD-UHFFFAOYSA-N
InChI
InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13)
IUPAC Name
3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoic acid
SMILES
CC(C)(CO)C(O)C(=O)NCCC(O)=O
Pharmacology
IndicationStudied for the treatment of many uses such as treatment of testicular torsion, diabetic ulceration, wound healing, acne, obesity, diabetic peripheral polyneuropathy. It has also been investigated for its hypolipidemic effects and as cholesterol lowering agent.
Structured Indications Not Available
PharmacodynamicsPantothenic acid is used in the synthesis of coenzyme A (CoA). Coenzyme A may act as an acyl group carrier to form acetyl-CoA and other related compounds; this is a way to transport carbon atoms within the cell. CoA is important in energy metabolism for pyruvate to enter the tricarboxylic acid cycle (TCA cycle) as acetyl-CoA, and for α-ketoglutarate to be transformed to succinyl-CoA in the cycle. CoA is also important in the biosynthesis of many important compounds such as fatty acids, cholesterol, and acetylcholine. CoA is incidentally also required in the formation of ACP, which is also required for fatty acid synthesis in addition to CoA. Pantothenic acid in the form of CoA is also required for acylation and acetylation, which, for example, are involved in signal transduction and enzyme activation and deactivation, respectively. Since pantothenic acid participates in a wide array of key biological roles, it is essential to all forms of life. As such, deficiencies in pantothenic acid may have numerous wide-ranging effects, as discussed below.
Mechanism of actionPantothenic acid is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
TargetKindPharmacological actionActionsOrganismUniProt ID
Pantothenate kinaseProteinunknownNot AvailableEscherichia coli (strain K12)P0A6I3 details
Related Articles
AbsorptionWhen found in foods, most pantothenic acid is in the form of CoA or acyl carrier protein (ACP). For the intestinal cells to absorb this vitamin, it must be converted into free pantothenic acid. Within the lumen of the intestine, CoA and ACP are hydrolyzed into 4'-phosphopantetheine. The 4'-phosphopantetheine is then dephosphorylated into pantetheine. Pantetheinase, an intestinal enzyme, then hydrolyzes pantetheine into free pantothenic acid. Free pantothenic acid is absorbed into intestinal cells via a saturable, sodium-dependent active transport system. At high levels of intake, when this mechanism is saturated, some pantothenic acid may also be absorbed via passive diffusion. As intake increases 10-fold, however, absorption rate decreases to 10%. [Wikipedia]
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNo Tolerable Upper Level Intake (UL) has been established for the vitamin.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Carnosinuria, carnosinemiaDiseaseSMP00493
Beta-Alanine MetabolismMetabolicSMP00007
Pantothenate and CoA BiosynthesisMetabolicSMP00027
GABA-Transaminase DeficiencyDiseaseSMP00351
Ureidopropionase deficiencyDiseaseSMP00492
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available
References
Synthesis Reference

John F. Verbeeck, “Process for the production of the calcium salt of pantothenic acid.” U.S. Patent US3935256, issued February, 1971.

US3935256
General References
  1. Trumbo, P. R. (2005). Pantothenic Acid. In Modern Nutrition in Health and Disease (10th ed., pp. 462–467). Lippincott Williams & Wilkins. [ISBN:0-7817-4133-5 ]
External Links
ATC CodesD03AX04A11HA31
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSDownload (47.9 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.6189
Blood Brain Barrier+0.6889
Caco-2 permeable-0.7055
P-glycoprotein substrateSubstrate0.5464
P-glycoprotein inhibitor INon-inhibitor0.836
P-glycoprotein inhibitor IINon-inhibitor0.9184
Renal organic cation transporterNon-inhibitor0.95
CYP450 2C9 substrateNon-substrate0.8235
CYP450 2D6 substrateNon-substrate0.8051
CYP450 3A4 substrateNon-substrate0.5411
CYP450 1A2 substrateNon-inhibitor0.9133
CYP450 2C9 inhibitorNon-inhibitor0.9137
CYP450 2D6 inhibitorNon-inhibitor0.9417
CYP450 2C19 inhibitorNon-inhibitor0.8929
CYP450 3A4 inhibitorNon-inhibitor0.9587
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9305
Ames testNon AMES toxic0.9278
CarcinogenicityNon-carcinogens0.9062
BiodegradationReady biodegradable0.662
Rat acute toxicity1.7394 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9968
hERG inhibition (predictor II)Non-inhibitor0.944
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
TabletOral1 g
ElixirOral
SolutionOral
PowderOral
Capsule, liquid filledOral
CapsuleOral
CapsuleOral250 mg
Tablet, extended releaseOral1 g
Tablet, effervescentOral
Tablet, extended releaseOral
Solution / dropsOral
LiquidIntravenous
Tablet, chewableOral
TabletOral250 mg
TabletOral500 mg
CapsuleOral500 mg
CapsuleOral100 mg
TabletOral100 mg
TabletOral200 mg
Tablet, extended releaseOral500 mg
TabletOral300 mg
Tablet, coatedOral
Capsule, gelatin coatedOral
TabletOral
KitOral
Capsule, extended releaseOral
LiquidOral
CapsuleOral300 mg
TabletOral50 mg
Tablet, film coatedOral
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point195ºC (D-Calcium Pantothenate salt)MSDS
water solubilitySolubleMSDS
Predicted Properties
PropertyValueSource
Water Solubility60.5 mg/mLALOGPS
logP-1.1ALOGPS
logP-1.4ChemAxon
logS-0.56ALOGPS
pKa (Strongest Acidic)4.35ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area106.86 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity51.51 m3·mol-1ChemAxon
Polarizability21.92 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-014i-3190000000-7a9e1fb7ca94ff4714e8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-00dl-9100000000-ada04a866c6d38235607View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0596-9000000000-aea14dc63426efd5a60dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,1H] 2D NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as beta amino acids and derivatives. These are amino acids having a (-NH2) group attached to the beta carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentBeta amino acids and derivatives
Alternative Parents
Substituents
  • Beta amino acid or derivatives
  • Fatty acyl
  • N-acyl-amine
  • Monosaccharide
  • Fatty amide
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Carboxamide group
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Pantothenate kinase activity
Specific Function:
Not Available
Gene Name:
coaA
Uniprot ID:
P0A6I3
Molecular Weight:
36359.435 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23