Alpha-1-acid glycoprotein 2

Details

Name
Alpha-1-acid glycoprotein 2
Synonyms
  • AGP 2
  • AGP2
  • OMD 2
  • Orosomucoid-2
Gene Name
ORM2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007040|Alpha-1-acid glycoprotein 2
MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQ
EIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQRENGTVSRYEGGREHVAHLL
FLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKK
DKCEPLEKQHEKERKQEEGES
Number of residues
201
Molecular Weight
23602.43
Theoretical pI
4.76
GO Classification
Processes
acute-phase response / regulation of immune system process / transport
Components
blood microparticle / extracellular exosome / extracellular space
General Function
Not Available
Specific Function
Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0012546|Alpha-1-acid glycoprotein 2 (ORM2)
ATGGCGCTGTCCTGGGTTCTTACAGTCCTGAGCCTCCTACCTCTGCTGGAAGCCCAGATC
CCATTGTGTGCCAACCTAGTACCGGTGCCCATCACCAACGCCACCCTGGACCGGATCACT
GGCAAGTGGTTTTATATCGCATCGGCCTTTCGAAACGAGGAGTACAATAAGTCGGTTCAG
GAGATCCAAGCAACCTTCTTTTACTTTACCCCCAACAAGACAGAGGACACGATCTTTCTC
AGAGAGTACCAGACCCGCCAGAACCAGTGCTTCTATAACTCCAGTTACCTGAATGTCCAG
CGGGAGAATGGGACCGTCTCCAGATACGAGGGAGGCCGAGAACATGTTGCTCACCTGCTG
TTCCTTAGGGACACCAAGACCTTGATGTTTGGTTCCTACCTGGACGATGAGAAGAACTGG
GGGCTGTCTTTCTATGCTGACAAGCCAGAGACGACCAAGGAGCAACTGGGAGAGTTCTAC
GAAGCTCTCGACTGCTTGTGCATTCCCAGGTCAGATGTCATGTACACCGACTGGAAAAAG
GATAAGTGTGAGCCACTGGAGAAGCAGCACGAGAAGGAGAGGAAACAGGAGGAGGGGGAA
TCCTAG
Chromosome Location
9
Locus
9q32
External Identifiers
ResourceLink
UniProtKB IDP19652
UniProtKB Entry NameA1AG2_HUMAN
GenBank Protein ID16359000
GenBank Gene IDBC015964
HGNC IDHGNC:8499
General References
  1. Dente L, Pizza MG, Metspalu A, Cortese R: Structure and expression of the genes coding for human alpha 1-acid glycoprotein. EMBO J. 1987 Aug;6(8):2289-96. [PubMed:2822385]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01593Zincapproved, investigationalunknownDetails
DB00280DisopyramideapprovedunknownDetails
DB00458ImipramineapprovedunknownDetails
DB00281Lidocaineapproved, vet_approvedunknownDetails
DB00333Methadoneapproved, illicitunknownDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownDetails
DB00477Chlorpromazineapproved, investigational, vet_approvedunknownbinderDetails
DB00497Oxycodoneapproved, illicit, investigationalunknownbinderDetails
DB01041Thalidomideapproved, investigational, withdrawnunknownbinderDetails
DB09262ImidafenacininvestigationalnosubstrateDetails
DB11828Neratinibapproved, investigationalnosubstrateDetails
DB00512VancomycinapprovednosubstrateDetails
DB12001Abemaciclibapproved, investigationalunknownbinderDetails
DB09053IbrutinibapprovednosubstrateDetails
DB11641Vinflunineapproved, investigationalnosubstrateDetails
DB14582Patisiranapproved, investigationalunknownligandDetails
DB00289AtomoxetineapprovednobinderDetails
DB00332Ipratropiumapproved, experimentalnobinderDetails