Identification

Name
Fentanyl
Accession Number
DB00813  (APRD00347, DB05853, DB06055, DB06220, DB05564)
Type
Small Molecule
Groups
Approved, Illicit, Investigational, Vet approved
Description

A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)

Structure
Thumb
Synonyms
  • 1-Phenethyl-4-(N-phenylpropionamido)piperidine
  • 1-phenethyl-4-N-propionylanilinopiperidine
  • Fentanil
  • Fentanila
  • Fentanilo
  • Fentanyl
  • Fentanyl CII
  • Fentanylum
  • N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide
  • N-(1-phenethyl-4-piperidyl)propionanilide
  • N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
  • N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide
  • N-phenethyl-4-(N-propionylanilino)piperidine
  • N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
  • Phentanyl
External IDs
AD 923 / AD-923 / IDS-NF-001 / McN-JR 4263-49 / N02AB03 / R 4263 / R 5240
Product Ingredients
IngredientUNIICASInChI Key
Fentanyl citrateMUN5LYG46H990-73-8IVLVTNPOHDFFCJ-UHFFFAOYSA-N
Fentanyl hydrochloride59H156XY461443-54-5LHCBOXPPRUIAQT-UHFFFAOYSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AbstralTablet800 ug/1SublingualProstrakan Pharmaceuticals2011-01-07Not applicableUs
AbstralTablet300 ug/1SublingualGalena Biopharma, Inc.2013-08-08Not applicableUs
AbstralTablet300 ug/1SublingualProstrakan Pharmaceuticals2011-01-07Not applicableUs
AbstralTablet600 mcgSublingualPaladin Labs Inc2011-06-14Not applicableCanada
AbstralTablet100 ug/1SublingualProstrakan Pharmaceuticals2011-01-07Not applicableUs
AbstralTablet200 mcgSublingualPaladin Labs Inc2011-04-18Not applicableCanada
AbstralTablet600 ug/1SublingualGalena Biopharma, Inc.2013-08-08Not applicableUs
AbstralTablet600 ug/1SublingualProstrakan Pharmaceuticals2011-01-07Not applicableUs
AbstralTablet200 ug/1SublingualGalena Biopharma, Inc.2013-08-08Not applicableUs
AbstralTablet400 mcgSublingualPaladin Labs Inc2011-04-18Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-fentanyl MatrixPatch100 mcgTransdermalApotex Corporation2009-05-13Not applicableCanada
Apo-fentanyl MatrixPatch25 mcgTransdermalApotex Corporation2009-05-13Not applicableCanada
Apo-fentanyl MatrixPatch50 mcgTransdermalApotex Corporation2009-05-13Not applicableCanada
Apo-fentanyl MatrixPatch12 mcgTransdermalApotex CorporationNot applicableNot applicableCanada
Apo-fentanyl MatrixPatch75 mcgTransdermalApotex Corporation2009-05-13Not applicableCanada
FentanylPatch, extended release25 ug/1hTransdermalApotex Corporation2010-03-012018-05-31Us
FentanylPatch, extended release50 ug/1hTransdermalActavis Pharma Company2007-08-21Not applicableUs
FentanylPatch, extended release100 ug/1hTransdermalH.J. Harkins Company2010-03-01Not applicableUs
FentanylPatch100 ug/1hTransdermalbryant ranch prepack2007-08-20Not applicableUs
FentanylPatch, extended release25 ug/1hTransdermalApotex Corporation2018-01-10Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Innovar InjFentanyl citrate (.05 mg) + Droperidol (2.5 mg)LiquidIntramuscular; IntravenousJanssen Pharmaceutica, Division Of Janssen Ortho Inc.1982-12-311996-09-10Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Fentanyl CitrateFentanyl citrate (20 ug/1mL)Injection, solutionIntravenousCantrell Drug Company2014-08-13Not applicableUs
Fentanyl CitrateFentanyl citrate (5 ug/1mL)Injection, solutionIntravenousCantrell Drug Company2013-11-22Not applicableUs
Fentanyl CitrateFentanyl citrate (10 ug/1mL)Injection, solutionEpidural; IntravenousCantrell Drug Company2013-04-232017-12-06Us
Fentanyl CitrateFentanyl citrate (50 ug/1mL)Injection, solutionIntravenousCantrell Drug Company2013-10-112017-12-06Us
Fentanyl CitrateFentanyl citrate (50 ug/1mL)Injection, solutionIntravenousCantrell Drug Company2011-10-20Not applicableUs
Fentanyl CitrateFentanyl citrate (25 ug/1mL)Injection, solutionIntravenousCantrell Drug Company2014-08-212017-12-06Us
Fentanyl Citrate, Bupivacaine HClFentanyl citrate (2 ug/1mL) + Bupivacaine hydrochloride monohydrate (1 mg/1mL)Injection, solutionEpiduralCantrell Drug Company2013-09-092017-12-06Us
Fentanyl Citrate, Bupivacaine HClFentanyl citrate (2 ug/1mL) + Bupivacaine hydrochloride monohydrate (1.25 mg/1mL)Injection, solutionEpiduralCantrell Drug Company2013-03-25Not applicableUs
Fentanyl Citrate, Bupivacaine HClFentanyl citrate (3 ug/1mL) + Bupivacaine hydrochloride monohydrate (1.25 mg/1mL)Injection, solutionEpiduralCantrell Drug Company2013-12-18Not applicableUs
Fentanyl Citrate, Bupivacaine HClFentanyl citrate (1 ug/1mL) + Bupivacaine hydrochloride monohydrate (1.25 mg/1mL)Injection, solutionEpiduralCantrell Drug Company2013-08-12Not applicableUs
International/Other Brands
Durogesic (Janssen) / Fentanest (Pfizer) / Nasalfent (Archimedes) / Rapinyl (Gedeon Richter)
Categories
UNII
UF599785JZ
CAS number
437-38-7
Weight
Average: 336.4705
Monoisotopic: 336.220163528
Chemical Formula
C22H28N2O
InChI Key
PJMPHNIQZUBGLI-UHFFFAOYSA-N
InChI
InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3
IUPAC Name
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
SMILES
CCC(=O)N(C1CCN(CCC2=CC=CC=C2)CC1)C1=CC=CC=C1

Pharmacology

Indication

For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy.

Associated Conditions
Associated Therapies
Pharmacodynamics

Fentanyl is an opioid analgesic. Fentanyl interacts predominately with the opioid mu-receptor but also binds to kappa and delta-type opioid receptors. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, Fentanyl exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Fentanyl may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Fentanyl depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.

Mechanism of action

Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Fentanyl's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hypopolarization and reduced neuronal excitability.

TargetActionsOrganism
AMu-type opioid receptor
agonist
Human
ADelta-type opioid receptor
agonist
Human
UKappa-type opioid receptor
agonist
Human
UMultidrug resistance protein 1Not AvailableHuman
Absorption

Bioavailability is 92% following transdermal administration and 50% following buccal administration.

Volume of distribution
  • 3 to 8 L/kg [Surgical Patients]
  • 0.8 to 8 [Hepatically Impaired Patients]
Protein binding

80-85%

Metabolism

Fentanyl is metabolized primarily via human cytochrome P450 3A4 isoenzyme system.

Route of elimination

Fentanyl is metabolized primarily via human cytochrome P450 3A4 isoenzyme system and mostly eliminated in urine. Within 72 hours of IV fentanyl administration, approximately 75% of the dose is excreted in urine, mostly as metabolites with less than 10% representing unchanged drug.

Half life

7 hours (range 3-12)

Clearance
  • 27 – 75 L/h [Surgical Patients receving IV administration]
  • 3 – 80 L/h [Hepatically Impaired Patients receving IV administration]
  • 30 – 78 L/h [Renally Impaired Patients receving IV administration]
Toxicity

Fentanyl has an LD50 of 3.1 milligrams per kilogram in rats, and, 0.03 milligrams per kilogram in monkeys. The LD50 in humans is not known.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Fentanyl Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Cytochrome P450 3A4CYP3A4*20Not Available1461_1462insAADR InferredPoor drug metabolizer, increased adverse drug effects, risk of potentially fatal respiratory depression.Details
Cytochrome P450 3A4CYP3A4*26Not Available802C>TADR InferredPoor drug metabolizer, increased adverse drug effects, risk of potentially fatal respiratory depression.Details

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe metabolism of Fentanyl can be decreased when combined with (R)-warfarin.
(S)-WarfarinThe metabolism of Fentanyl can be decreased when combined with (S)-Warfarin.
2,5-Dimethoxy-4-ethylamphetamineThe risk or severity of serotonin syndrome can be increased when Fentanyl is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamineThe risk or severity of serotonin syndrome can be increased when Fentanyl is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
3,4-MethylenedioxyamphetamineThe risk or severity of serotonin syndrome can be increased when Fentanyl is combined with 3,4-Methylenedioxyamphetamine.
3,5-diiodothyropropionic acidThe metabolism of Fentanyl can be decreased when combined with 3,5-diiodothyropropionic acid.
4-Bromo-2,5-dimethoxyamphetamineThe risk or severity of serotonin syndrome can be increased when Fentanyl is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be decreased when combined with Fentanyl.
4-MethoxyamphetamineThe therapeutic efficacy of Fentanyl can be decreased when used in combination with 4-Methoxyamphetamine.
5-androstenedioneThe metabolism of Fentanyl can be decreased when combined with 5-androstenedione.
Food Interactions
  • Avoid alcohol.

References

Synthesis Reference

Mark Rubino, "Process of making fentanyl intermediates." U.S. Patent US20060100438, issued May 11, 2006.

US20060100438
General References
  1. Van Bever WF, Niemegeers CJ, Janssen PA: Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-(3-methyl-1-(2-phenylethyl)-4-piperidyl)-N-phenylpropanamide and N-(3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl)-N-phenylpropanamide. J Med Chem. 1974 Oct;17(10):1047-51. [PubMed:4420811]
  2. Messina J, Darwish M, Fine PG: Fentanyl buccal tablet. Drugs Today (Barc). 2008 Jan;44(1):41-54. doi: 10.1358/dot.2008.44.1.1178469. [PubMed:18301803]
  3. Taylor DR: Fentanyl buccal tablet: rapid relief from breakthrough pain. Expert Opin Pharmacother. 2007 Dec;8(17):3043-51. [PubMed:18001263]
  4. Simpson DM, Messina J, Xie F, Hale M: Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: a multicenter, randomized, double-blind, placebo-controlled study. Clin Ther. 2007 Apr;29(4):588-601. [PubMed:17617282]
External Links
Human Metabolome Database
HMDB0014951
KEGG Drug
D00320
PubChem Compound
3345
PubChem Substance
46506372
ChemSpider
3228
BindingDB
50008984
ChEBI
119915
ChEMBL
CHEMBL596
Therapeutic Targets Database
DAP000072
PharmGKB
PA449599
IUPHAR
1626
Guide to Pharmacology
GtP Drug Page
HET
7V7
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Fentanyl
ATC Codes
N01AH51 — Fentanyl, combinationsN01AH01 — FentanylN02AB03 — Fentanyl
AHFS Codes
  • 28:08.08 — Opiate Agonists
PDB Entries
5tzo
FDA label
Download (507 KB)
MSDS
Download (75.5 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentDyspnea1
0CompletedTreatmentEmergence Agitation / Pain NOS1
0CompletedTreatmentLumbar Spinal Instability / Lumbar Spine Degeneration / Spinal Stenosis of Lumbar Region1
0RecruitingTreatmentMalignant Neoplasms of Respiratory and Intrathoracic Organs1
1Active Not RecruitingTreatmentHead and Neck Carcinoma / Oral Mucositis1
1CompletedNot AvailableHealthy Volunteers4
1CompletedNot AvailablePostoperative pain1
1CompletedBasic SciencePharmacokinetics and Pharmacodynamics1
1CompletedBasic SciencePharmacology1
1CompletedOtherHealthy Volunteers1
1CompletedSupportive CareOther Acute Pain / Pain Experienced During Cystoscopy1
1CompletedTreatmentBreakthrough Pain1
1CompletedTreatmentHealthy Volunteers3
1CompletedTreatmentLabour Pain1
1CompletedTreatmentOpiate Addiction1
1CompletedTreatmentPain NOS4
1Not Yet RecruitingSupportive CareNear Infrared Spectroscopy / Respiratory Distress Syndrome (RDS) / Surfactant Deficiency Syndrome Neonatal1
1TerminatedBasic ScienceImmunologic Activity Alteration / Immunologic Activity Alteration [PE] / Pro-inflammatory Activity1
1Unknown StatusTreatmentObstructive Sleep Apnea of Adult1
1, 2Active Not RecruitingTreatmentCesarean Section / Lumbar epidural anesthesia therapy1
1, 2CompletedPreventionPost Operative Pain2
1, 2CompletedSupportive CareAdvanced Cancers / Dyspnea1
1, 2CompletedTreatmentMalignancies / Pain, Chronic1
1, 2CompletedTreatmentPain, Fracture, Sprain1
1, 2CompletedTreatmentRadical Mastectomy1
1, 2RecruitingTreatmentPain, Acute1
2Active Not RecruitingTreatmentAdvanced Cancers1
2CompletedPreventionAdverse Anesthesia Outcome1
2CompletedSupportive CareChildren1
2CompletedTreatmentAnaesthesia therapy1
2CompletedTreatmentAtrioventricular Septal Defects / Atrioventricular Septal Defects (AVSD) / Tetralogy Of Fallot / Tetralogy of Fallot (TOF) / Ventricular Septal Defects / Ventricular Septal Defects (VSD)1
2CompletedTreatmentBreakthrough Pain / Malignancies1
2CompletedTreatmentCongestive Heart Failure (CHF) / Dyspnea1
2CompletedTreatmentHeroin Dependence / Opioid-Related Disorders / Substance-Related Disorders1
2CompletedTreatmentIrritable Bowel Syndrome (IBS)1
2CompletedTreatmentMalignancies / Pain NOS2
2CompletedTreatmentMalignancies / Pain NOS / Severe Burns / Sickle Cell Disorders1
2CompletedTreatmentPain NOS2
2CompletedTreatmentPain, Chronic1
2CompletedTreatmentPain, Intractable1
2CompletedTreatmentSedation, Conscious1
2CompletedTreatmentAdjunct to general anesthesia therapy1
2Not Yet RecruitingSupportive CareReferred Pain1
2Not Yet RecruitingTreatmentBreakthrough Cancer Pain / Malignancies1
2Not Yet RecruitingTreatmentPain, Acute1
2RecruitingSupportive CareCancer of the Breast / Cancer, Breast / Malignant Neoplasm of Female Breast1
2RecruitingTreatmentAdministration and Dosage of Ketamine / Endoscopic Sedation1
2RecruitingTreatmentBloodpressure / Heart Rate1
2RecruitingTreatmentDelirium1
2RecruitingTreatmentFractures, Bone1
2RecruitingTreatmentIntrathecal Dexmedetomidine / Pediatric Cancer Surgery1
2RecruitingTreatmentPain NOS1
2TerminatedSupportive CareBone Metastases1
2TerminatedSupportive CareNeoplasms, Malignant1
2Unknown StatusSupportive CareIntracranial Hemorrhages / Ischemia, Brain / Strokes / Vasospasm, Intracranial1
2WithdrawnSupportive CareTraumatic Brain Injury (TBI)1
2WithdrawnTreatmentHb-SS Disease With Vasoocclusive Pain / Hemoglobin SS Disease With Crisis / Hemoglobin SS Disease With Vasoocclusive Crisis / Other Sickle Cell Disease With Vaso-Occlusive Pain / Sickle Cell Disorders1
2, 3CompletedPreventionHypospadias1
2, 3CompletedPreventionPain NOS1
2, 3CompletedTreatmentAnaesthesia therapy1
2, 3CompletedTreatmentChronic Otitis Media1
2, 3CompletedTreatmentConscious Sedation During Procedure / Endobronchial Ultrasound1
2, 3CompletedTreatmentIntracranial Surgery1
2, 3CompletedTreatmentPain Due to Certain Specified Procedures1
2, 3CompletedTreatmentSedation therapy1
2, 3RecruitingOtherLow Dose of Pethidine for Subarachnoid Anesthesia1
2, 3RecruitingTreatmentAnalgesia, Postoperative1
2, 3RecruitingTreatmentArterial Hypotension1
2, 3RecruitingTreatmentAsthma Bronchial / Bronchospasm / Critical Illness1
2, 3RecruitingTreatmentObstetrical analgesia therapy / Obstetrical Anesthesia / Postpartum Depression1
2, 3TerminatedSupportive CareDecrease Labor Pain1
2, 3Unknown StatusSupportive CareStillborn Caesarean Section1
3CompletedNot AvailablePain NOS1
3CompletedDiagnosticCancer, Breast1
3CompletedPreventionObstructive Sleep Apnea (OSA)1
3CompletedPreventionPost-operative Pain for Total Knee Arthroplasty1
3CompletedSupportive CareCancers, Pain2
3CompletedSupportive CarePain NOS1
3CompletedSupportive CarePain, Cancer2
3CompletedSupportive CarePostoperative pain1
3CompletedTreatmentAbscesses / Pain NOS1
3CompletedTreatmentAnaesthesia therapy1
3CompletedTreatmentAnaesthesia therapy / Craniotomy / Neurosurgery1
3CompletedTreatmentAnalgesia / Neonatal Infections / Pain NOS1
3CompletedTreatmentAnesthetic, Sedative and Analgesic Complications in Labor or Delivery / Anesthetic, Sedative or Analgesic Complications in Labor or Delivery1
3CompletedTreatmentBack Pain Lower Back / Osteoarthritis (OA) / Pain, Chronic1
3CompletedTreatmentBreak Through Pain / Malignancies1
3CompletedTreatmentBreakthrough Pain1
3CompletedTreatmentBreakthrough Pain / Malignancies1
3CompletedTreatmentCancer Related Pain (Breakthrough Pain)1
3CompletedTreatmentComplex Regional Pain Syndromes (CRPS) / Postherpetic Neuralgia / Postoperative pain1
3CompletedTreatmentCongenital Cystic Adenomatoid Malformation (CCAM)1
3CompletedTreatmentGeneral Anaesthesia1
3CompletedTreatmentInfant, Premature, Diseases / Pain NOS / Respiration; Insufficient or Poor, Newborn1
3CompletedTreatmentInhalation of Nitrous Oxide / Opioid Analgesic Adverse Reaction / Pain NOS1
3CompletedTreatmentLocal Anesthesia1
3CompletedTreatmentMalignancies2
3CompletedTreatmentMalignancies / Pain NOS2
3CompletedTreatmentOpioids Use / Pain, Chronic1
3CompletedTreatmentPain NOS3
3CompletedTreatmentPain NOS / Traumatic Limb Injury1
3CompletedTreatmentPain, Cancer1
3CompletedTreatmentPain, Chronic3
3CompletedTreatmentPain, Intractable1
3CompletedTreatmentPostoperative pain2
3CompletedTreatmentSedation therapy1
3CompletedTreatmentStandard Opioid Analgesic Treatment of Cancer-related Chronic Pain1
3CompletedTreatmentVentilations, Mechanical1
3Not Yet RecruitingTreatmentAppendicitis Acute / Inguinal Hernias1
3Not Yet RecruitingTreatmentArterial Occlusive Diseases1
3Not Yet RecruitingTreatmentPain, Acute1
3RecruitingPreventionAdjunct to general anesthesia therapy / Anaesthesia therapy / Analgesics / Analgesics, Opioid / Dexmedetomidine / Gabapentin / Ketamine / Lidocaine / Narcotics / Obstructive Sleep Apnea of Child / Oximetry, Pulse / Pathologic Processes / Physiologic Effects of Drugs / Postoperative Complications / Respiratory Depression / Sleep Disordered Breathing (SDB) / Tonsillectomy1
3RecruitingSupportive CareMalignant Head and Neck Neoplasm / Mucositis / Radiation-Induced Disorder1
3RecruitingSupportive CarePreoperative Sedation1
3RecruitingTreatmentAnaplastic Astrocytoma of Brain / Glioblastoma Multiforme of Brain1
3RecruitingTreatmentBMI >30 kg/m21
3RecruitingTreatmentBreakthrough Pain1
3RecruitingTreatmentIdiopathic Pulmonary Fibrosis (IPF)1
3RecruitingTreatmentMalignancies / Pain NOS1
3RecruitingTreatmentMalignant Neoplasm of Pancreas1
3TerminatedPreventionTransient Neurologic Syndrome1
3TerminatedTreatmentAnalgesia, Postoperative / Opioid Free Anaesthesia1
3TerminatedTreatmentBone Marrow Diseases / Pain NOS1
3TerminatedTreatmentBreakthrough Pain / Pain NOS / Pain, Chronic1
3TerminatedTreatmentMalignancies / Pain NOS1
3Unknown StatusSupportive CareMalignancies / Pain NOS1
3Unknown StatusTreatmentBreakthrough Cancer Pain1
3Unknown StatusTreatmentIntubation Complications1
3Unknown StatusTreatmentObesity, Morbid1
3WithdrawnTreatmentLabour Pain1
3WithdrawnTreatmentPain NOS / Palliative Care1
3WithdrawnTreatmentPain, Chronic1
4Active Not RecruitingTreatmentAcute Lung Injury (ALI) / Acute Respiratory Distress Syndrome (ARDS) / Critical Illness / Sleep1
4Active Not RecruitingTreatmentAcute Pain Due to Trauma2
4Active Not RecruitingTreatmentAnaesthesia therapy1
4CompletedNot AvailableBack Pain Lower Back2
4CompletedNot AvailableDigestive System Diseases / Disorientation1
4CompletedNot AvailableFailed Moderate Sedation During Procedure1
4CompletedBasic ScienceAnalgesic Drugs / Antinociceptive Agents1
4CompletedDiagnosticPain NOS1
4CompletedDiagnosticToothache1
4CompletedHealth Services ResearchAmputation Stumps1
4CompletedHealth Services ResearchColon Cancer, Rectal Cancer1
4CompletedHealth Services ResearchPostoperative pain1
4CompletedOtherHealthy Volunteers1
4CompletedPreventionAmbulatory Surgery / Coughing1
4CompletedPreventionCognitive Impairments1
4CompletedPreventionCritical Illness / Pain NOS1
4CompletedPreventionFentanyl / Pain, Chronic / Remifentanil / Sternotomy1
4CompletedPreventionHeart Diseases / Hyperglycemias1
4CompletedPreventionIntubation, Endotracheal1
4CompletedPreventionPain, Chronic / Postoperative pain1
4CompletedPreventionSleep Apnea Syndromes / Sleep Apnea, Obstructive1
4CompletedPreventionSurgery, Laparoscopic1
4CompletedScreeningPatients Undergoing Major Abdominal Surgery / Postoperative Confusion1
4CompletedSupportive CareAdministration Site Reaction1
4CompletedSupportive CareAnesthesia; Reaction1
4CompletedSupportive CareCongenital Muscular Torticollis1
4CompletedSupportive CareHypothermia1
4CompletedSupportive CareHysterectomy (MeSH nr: E04.950.300.399)1
4CompletedSupportive CareInfertilities1
4CompletedSupportive CareLabour Pain1
4CompletedSupportive CareLumbar Spine Disc Herniation1
4CompletedSupportive CareNeoplasms, Thyroid1
4CompletedSupportive CarePain NOS1
4CompletedTreatmentAbscesses / Pain NOS1
4CompletedTreatmentAnaesthesia therapy1
4CompletedTreatmentAnalgesia1
4CompletedTreatmentAnalgesia, Patient-Controlled / Pain NOS / Postoperative pain1
4CompletedTreatmentArthritis / Osteoarthritis (OA)1
4CompletedTreatmentArthritis / Osteoarthritis (OA) / Rheumatoid Arthritis1
4CompletedTreatmentBack Pain Lower Back / Osteoarthritis (OA)1
4CompletedTreatmentBreakthrough Pain / Pain, Chronic / Pain, Intractable1
4CompletedTreatmentCancer of Head and Neck / Pain NOS1
4CompletedTreatmentColonoscopy / Sedation, Conscious1
4CompletedTreatmentCondition: Abdominal Bone Flap Cranioplasty; Focus of Study: Perioperative Analgesia1
4CompletedTreatmentConscious Sedation Failure During Procedure1
4CompletedTreatmentCoronary Artery Disease1
4CompletedTreatmentCurettage / Pregnancy termination therapy1
4CompletedTreatmentDexmedetomidine in Subarachnoidal Anesthesia1
4CompletedTreatmentEndoscopic Retrograde Cholangiopancreatography1
4CompletedTreatmentEndoscopy1
4CompletedTreatmentEndoscopy / Inflammatory Bowel Diseases (IBD) / Sedation therapy1
4CompletedTreatmentFailed Moderate Sedation During Procedure1
4CompletedTreatmentCaudal epidural block therapy / Forearm Injuries / Orthopedic Procedures / Traumas / Upper Extremity1
4CompletedTreatmentFracture Bone / Pain NOS1
4CompletedTreatmentGall Stone Disease1
4CompletedTreatmentHemodynamic Response / Skull Pins Application1
4CompletedTreatmentInadequate or Impaired Respiratory Function / Pain NOS1
4CompletedTreatmentIntubations / Newborns / Preterms1
4CompletedTreatmentKnee Osteoarthritis (Knee OA)2
4CompletedTreatmentLabour Pain2
4CompletedTreatmentLung Function1
4CompletedTreatmentComputerized tomography / MRI of liver / Ultrasound1
4CompletedTreatmentMalignancies / Pain, Cancer1
4CompletedTreatmentMigraine Disorders1
4CompletedTreatmentMinor Procedural Pain1
4CompletedTreatmentOocyte Retrieval / Postoperative pain1
4CompletedTreatmentNeurocostal neuralgia / Opioid-Related Disorders1
4CompletedTreatmentCaudal epidural block therapy / Orthopedic Procedures / Shoulder1
4CompletedTreatmentOtitis1
4CompletedTreatmentOtitis Media (OM)1
4CompletedTreatmentPain NOS4
4CompletedTreatmentPain NOS / Quality of Life1
4CompletedTreatmentPain NOS / Sickle Cell Disorders2
4CompletedTreatmentPain, Chronic2
4CompletedTreatmentPain, Chronic / Postoperative pain1
4CompletedTreatmentPost-Operative Pain1
4CompletedTreatmentPostoperative Pain After Breast Reconstruction With Abdominal Flap1
4CompletedTreatmentPostoperative pain5
4CompletedTreatmentPostoperative pain / Surgery, Thoracic1
4CompletedTreatmentSedation therapy1
4CompletedTreatmentSepsis / Shock, Septic / Systemic Inflammatory Response Syndrome (SIRS)1
4CompletedTreatmentTerminal Cancer1
4CompletedTreatmentTonsillitis1
4CompletedTreatmentTotal Knee Arthroplasty (TKA)1
4Enrolling by InvitationSupportive CareSmooth muscle relaxation prior to radiological procedures1
4Enrolling by InvitationTreatmentAnesthesia Complication / Hemodynamics Instability / Ileus paralytic / Nausea / Postoperative pain / Vomiting1
4Enrolling by InvitationTreatmentComplications / Delirium / Ventilations, Mechanical1
4Not Yet RecruitingPreventionLabour Pain / Pain, Obstetric1
4Not Yet RecruitingSupportive CareBronchoscopy1
4Not Yet RecruitingTreatmentAnaesthesia therapy / Depression / Ketamine1
4Not Yet RecruitingTreatmentAnalgesics, Opioid / Anti-Inflammatory Agents, Non-Steroidal / Child/Adolescent Problems / Emergency Service, Hospital / Fentanyl / Ibuprofen / Pain, Acute1
4Not Yet RecruitingTreatmentHeadaches1
4Not Yet RecruitingTreatmentInfertility, Female / Postoperative pain1
4Not Yet RecruitingTreatmentKnee Replacement, Total1
4Not Yet RecruitingTreatmentOpioids Use / Postoperative pain1
4RecruitingDiagnosticLiver Diseases1
4RecruitingHealth Services ResearchMalignant Neoplasm of Female Breast1
4RecruitingOtherAdverse Reaction to Spinal Anesthetic / Maternal Care for Cervical Incompetence1
4RecruitingOtherAnaesthesia therapy1
4RecruitingOtherPeer Review, Research1
4RecruitingPreventionAnaesthesia therapy / Hip Fractures1
4RecruitingPreventionLabour Pain1
4RecruitingPreventionLaparoscopic Sleeve Gastrectomy / Post-Operative Nausea and Vomiting (PONV)1
4RecruitingSupportive CareBreakthrough Pain / Gastrostomy / Neoplasms, Upper Aerodigestive Tract1
4RecruitingSupportive CareColon Diverticulosis / Colonic Neoplasms / Constipation Drug Induced / Diverticulitis, Colonic / Ileus / Ileus paralytic / Ileus; Mechanical / Malignant Neoplasm of Colon / Occasional Constipation / Postoperative pain / Rectum Cancer / Rectum Neoplasm1
4RecruitingSupportive CareCongenital Heart Disease (CHD)1
4RecruitingSupportive CareCritical Care / Intensive Care / Multiple Organ Failure1
4RecruitingTreatmentAcute Agitation / Respiratory Failure / Sepsis1
4RecruitingTreatmentAcute Pain Due to Trauma1
4RecruitingTreatmentAnaesthesia therapy / Delirium / Hip Fractures1
4RecruitingTreatmentBladder Tumors / Postoperative Cognitive Dysfunction1
4RecruitingTreatmentChronic Obstructive Pulmonary Disease (COPD)1
4RecruitingTreatmentColonoscopy / Pain NOS1
4RecruitingTreatmentComplications; Cesarean Section1
4RecruitingTreatmentDexmedetomidine / Mechanically Ventilated Sedated Patients / Midazolam / Sedation therapy / Ventilations, Mechanical1
4RecruitingTreatmentLabour Pain / Lumbar epidural anesthesia therapy / Opioids1
4RecruitingTreatmentLaceration of Skin1
4RecruitingTreatmentOtitis Media (OM) / Postoperative pain1
4RecruitingTreatmentPain NOS2
4RecruitingTreatmentPain, Acute1
4RecruitingTreatmentPectus Excavatum1
4RecruitingTreatmentPercutaneous Coronary Intervention1
4RecruitingTreatmentPost-operative Residual Curarization1
4RecruitingTreatmentPostoperative pain2
4RecruitingTreatmentRib Fracture Multiple / Rib Fractures1
4RecruitingTreatmentST Elevation Myocardial Infarction (STEMI)1
4RecruitingTreatmentShock, Septic1
4RecruitingTreatmentSupracondylar Fractures1
4SuspendedTreatmentPain, Chronic1
4TerminatedNot AvailableBreakthrough Pain / Pain, Cancer1
4TerminatedTreatmentCritical Illness / Ventilations, Mechanical1
4TerminatedTreatmentOrthopedic Procedures / Procedural Sedation / Regional Anesthesia Block1
4TerminatedTreatmentPain NOS4
4TerminatedTreatmentPain, Acute / Posttraumatic Stress Disorders / Wound Care1
4TerminatedTreatmentPostoperative pain2
4Unknown StatusDiagnosticSafety of Gastroscopy1
4Unknown StatusPreventionDelirium1
4Unknown StatusPreventionSedative Withdrawal Delirium1
4Unknown StatusTreatmentAnaesthesia therapy / Hemodynamics / Oxidative Stress1
4Unknown StatusTreatmentCesarean Section / Local Anaesthetics Causing Adverse Effects in Therapeutic Use / Spinal Anaesthesia1
4Unknown StatusTreatmentDelirium1
4Unknown StatusTreatmentEmergency1
4Unknown StatusTreatmentEpidural Block / Labour / Pregnancy / Primigravida Labour1
4Unknown StatusTreatmentFailed Conscious Sedation During Procedure1
4Unknown StatusTreatmentLabour Pain1
4Unknown StatusTreatmentLiver Cirrhosis1
4Unknown StatusTreatmentMechanical Ventilation Complication1
4Unknown StatusTreatmentPain NOS / Traumas1
4Unknown StatusTreatmentSafety of Dexmedetomidine Sedation1
4Unknown StatusTreatmentAdjunct to general anesthesia therapy1
4WithdrawnPreventionC.Surgical Procedure; Cardiac / Delirium1
4WithdrawnSupportive CarePain NOS1
4WithdrawnTreatmentAbscesses1
4WithdrawnTreatmentPostoperative pain1
4WithdrawnTreatmentSleep1
Not AvailableActive Not RecruitingNot AvailableAAT Deficiency / AATD / Alpha-1 Antitrypsin Deficiency / Fibrosis, Liver1
Not AvailableActive Not RecruitingSupportive CareAnaesthesia therapy / Chronic Lung Diseases / Nephrectomy1
Not AvailableActive Not RecruitingTreatmentPain NOS2
Not AvailableActive Not RecruitingTreatmentPain, Chronic1
Not AvailableActive Not RecruitingTreatmentPulmonary Diseases1
Not AvailableCompletedNot AvailableAdequate Anesthesia With Unimpaired Motor Strength1
Not AvailableCompletedNot AvailableAnaesthesia therapy / Maternal Hypotension1
Not AvailableCompletedNot AvailableBreakthrough Cancer Pain / Pain, Cancer / Pain, Neuropathic / Tumors1
Not AvailableCompletedNot AvailableBreakthrough Cancer Pain / Quality of Life1
Not AvailableCompletedNot AvailableBreakthrough Pain / Malignancies1
Not AvailableCompletedNot AvailableCancer of the Ovary / Cervical Cancers / Endometrial Cancers / Fallopian Tube Cancer / Pain NOS / Perioperative/Postoperative Complications / Sarcomas1
Not AvailableCompletedNot AvailableChronic Obstructive Pulmonary Disease (COPD)1
Not AvailableCompletedNot AvailableColonoscopy / Fentanyl / Ketamine1
Not AvailableCompletedNot AvailableHorner's Syndrome1
Not AvailableCompletedNot AvailableLabour Pain1
Not AvailableCompletedNot AvailableMalignancies / Pain NOS1
Not AvailableCompletedNot AvailableObstructive Sleep Apnea (OSA)1
Not AvailableCompletedNot AvailablePain NOS1
Not AvailableCompletedNot AvailablePharmacogenetic and Duration of Labor Fentanyl Analgesia1
Not AvailableCompletedNot AvailableRenal Failure1
Not AvailableCompletedNot AvailableSevere, Chronic Pain1
Not AvailableCompletedBasic ScienceBioavailability1
Not AvailableCompletedBasic ScienceLaparoscopic Cholecystectomy1
Not AvailableCompletedDiagnosticHealthy Volunteers1
Not AvailableCompletedDiagnosticSacroiliac Joint Pain / Sympathetically Maintained Pain1
Not AvailableCompletedHealth Services ResearchElective Caesarean Section1
Not AvailableCompletedOtherPain NOS1
Not AvailableCompletedPreventionAcute Agitation1
Not AvailableCompletedPreventionAmputation Stumps1
Not AvailableCompletedPreventionAnesthesia Emergence Delirium1
Not AvailableCompletedPreventionCancer, Breast / Post-Operative Nausea and Vomiting (PONV) / Postoperative pain1
Not AvailableCompletedPreventionCesarean Section1
Not AvailableCompletedPreventionCoughing Responses at Tracheal Extubation1
Not AvailableCompletedPreventionDonor Hepatectomy1
Not AvailableCompletedPreventionEmergence Delirium1
Not AvailableCompletedPreventionGeneral Surgery1
Not AvailableCompletedPreventionGeneral Surgery / Prostate Cancer1
Not AvailableCompletedPreventionPain NOS1
Not AvailableCompletedPreventionPost-Operative Nausea and Vomiting (PONV)1
Not AvailableCompletedPreventionPostoperative pain1
Not AvailableCompletedSupportive CareAnesthesia Intubation Complications1
Not AvailableCompletedSupportive CarePain NOS1
Not AvailableCompletedSupportive CareRespiratory Failure1
Not AvailableCompletedSupportive CareUreteroneocystostomy1
Not AvailableCompletedTreatmentAcute Myocardial Infarction (AMI)1
Not AvailableCompletedTreatmentAcute Renal Colic1
Not AvailableCompletedTreatmentAnaesthesia therapy1
Not AvailableCompletedTreatmentAnaesthesia therapy / Immunotoxicity / Inert Gas Narcosis1
Not AvailableCompletedTreatmentAnalgesia, Postoperative1
Not AvailableCompletedTreatmentBPH( Benign Prostate Hyperplasia) / TURP(Transurethral Resection of Prostate)1
Not AvailableCompletedTreatmentCesarean Delivery1
Not AvailableCompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
Not AvailableCompletedTreatmentComplex Regional Pain Syndromes (CRPS) / Peripheral Neuropathy / Peripheral Neuropathy, CRPS1 and Postamputation Pain1
Not AvailableCompletedTreatmentComplication of Gastrostomy1
Not AvailableCompletedTreatmentCongenital Skelectal Anomaly1
Not AvailableCompletedTreatmentFemoral Fractures1
Not AvailableCompletedTreatmentFentanyl Analgesia1
Not AvailableCompletedTreatmentHip Fracture Surgery / Post Operative Pain Control1
Not AvailableCompletedTreatmentHip Fractures1
Not AvailableCompletedTreatmentKnee Osteoarthritis (Knee OA) / Osteoarthritis of the Shoulder / Osteoarthritis, Hip1
Not AvailableCompletedTreatmentKnee Replacement Surgery / Primary Knee Arthroplasty1
Not AvailableCompletedTreatmentLabour Pain2
Not AvailableCompletedTreatmentAdjunct to general anesthesia therapy / Laparoscopic Cholecystectomy1
Not AvailableCompletedTreatmentLiving Donor Liver Transplantation1
Not AvailableCompletedTreatmentOpioid Consumption / Postoperative pain1
Not AvailableCompletedTreatmentPain NOS1
Not AvailableCompletedTreatmentPain NOS / Perioperative/Postoperative Complications1
Not AvailableCompletedTreatmentPain Uterus1
Not AvailableCompletedTreatmentPain, Chronic1
Not AvailableCompletedTreatmentPost Operative Pain Management1
Not AvailableCompletedTreatmentPostoperative pain1
Not AvailableCompletedTreatmentPregnancy1
Not AvailableCompletedTreatmentProstate Cancer1
Not AvailableCompletedTreatmentRespiration Disorders1
Not AvailableCompletedTreatmentSpinal Anaesthesia1
Not AvailableEnrolling by InvitationPreventionPostoperative Delirium1
Not AvailableNot Yet RecruitingNot AvailableDrug Effect1
Not AvailableNot Yet RecruitingNot AvailableRespiratory Depression1
Not AvailableNot Yet RecruitingPreventionHeart Rate / Mean Arterial Pressure1
Not AvailableNot Yet RecruitingPreventionCaudal epidural block therapy / Postoperative pain / Surgery, Cardiac1
Not AvailableNot Yet RecruitingSupportive CareFemale Breast Cancer1
Not AvailableNot Yet RecruitingTreatmentAnaesthesia therapy / Malignancies / Pain NOS1
Not AvailableNot Yet RecruitingTreatmentAtherosclerosis / Coronary Artery Disease / Feeling Anxious / Pain, Acute / Vasospasm;Peripheral / Virtual Reality1
Not AvailableNot Yet RecruitingTreatmentColonic Neoplasms1
Not AvailableNot Yet RecruitingTreatmentLabour Analgesia1
Not AvailableNot Yet RecruitingTreatmentObesity, Morbid1
Not AvailableNot Yet RecruitingTreatmentPostoperative Recovery / Transurethral Resection of the Bladder / Urinary Bladder Neoplasms1
Not AvailableNot Yet RecruitingTreatmentPostoperative pain1
Not AvailableNot Yet RecruitingTreatmentSedation therapy1
Not AvailableNot Yet RecruitingTreatmentThoracic Epidural Analgesia, Fracture Ribs1
Not AvailableRecruitingNot AvailableAsphyxia Neonatorum1
Not AvailableRecruitingNot AvailableOpioids Use / Stress Reaction1
Not AvailableRecruitingNot AvailableRenal Failure1
Not AvailableRecruitingBasic ScienceHeart Failure, Unspecified1
Not AvailableRecruitingDiagnosticVentricular Tachycardia (VT)1
Not AvailableRecruitingHealth Services ResearchOpioid Free Anaesthesia1
Not AvailableRecruitingPreventionIntubation; Difficult or Failed1
Not AvailableRecruitingPreventionLabour Pain / Postpartum Depression1
Not AvailableRecruitingPreventionPregnancy1
Not AvailableRecruitingScreeningAnaesthesia therapy1
Not AvailableRecruitingSupportive CareDexmedetomidine VS Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries1
Not AvailableRecruitingSupportive CareRadical Cystectomy1
Not AvailableRecruitingTreatmentAcute Respiratory Failure1
Not AvailableRecruitingTreatmentAnaesthesia therapy / General Surgery / Pain NOS1
Not AvailableRecruitingTreatmentBronchoscopy / Sedation therapy1
Not AvailableRecruitingTreatmentChronic Pain, Postoperative / Postoperative pain1
Not AvailableRecruitingTreatmentColonoscopy1
Not AvailableRecruitingTreatmentHip Fractures1
Not AvailableRecruitingTreatmentNausea / Pain NOS1
Not AvailableRecruitingTreatmentOpioid Use, Unspecified1
Not AvailableRecruitingTreatmentPost Laparotomy Pain Treatment1
Not AvailableRecruitingTreatmentPostoperative Pain Control / Wrist Injury1
Not AvailableRecruitingTreatmentPostoperative pain2
Not AvailableRecruitingTreatmentRupture of Anterior Cruciate Ligament / Tear of Anterior Cruciate Ligament1
Not AvailableRecruitingTreatmentThe Comparison of the I-gel and Endotracheal Tube About in Different Ventilation Settings During Laparoscopic Surgery1
Not AvailableTerminatedNot AvailableBrain and Central Nervous System Tumors / Chronic Myeloproliferative Disorders / Leukemias / Lymphoproliferative Disorders / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms / Pain NOS / Precancerous Conditions / Unspecified Adult Solid Tumor, Protocol Specific1
Not AvailableTerminatedNot AvailableComplications; Cesarean Section / Effects of; Anesthesia, Spinal and Epidural, in Pregnancy / Hemodynamics Instability / Personal Satisfaction1
Not AvailableTerminatedTreatmentAdvanced Cancers / Malignant Pleural Effusions1
Not AvailableTerminatedTreatmentBMI >30 kg/m2 / Sleep Apnea, Obstructive1
Not AvailableTerminatedTreatmentPain NOS1
Not AvailableTerminatedTreatmentPostoperative pain / Shoulder Pain1
Not AvailableTerminatedTreatmentProcedural Sedation / Procedural Sedation and Analgesia1
Not AvailableTerminatedTreatmentRespiratory Failure1
Not AvailableUnknown StatusNot AvailableNausea / Vomiting1
Not AvailableUnknown StatusSupportive CareBishop Score / Cervical Dilatation / Duration of Delivery1
Not AvailableUnknown StatusSupportive CareDiverticulosis, Colonic / Malignant Neoplasm of Colon / Rectal Carcinoma1
Not AvailableUnknown StatusSupportive CareAdjunct to general anesthesia therapy1
Not AvailableUnknown StatusTreatmentAnalgesia1
Not AvailableUnknown StatusTreatmentLiver Diseases1
Not AvailableUnknown StatusTreatmentOpioid Dependence1
Not AvailableUnknown StatusTreatmentPain NOS1
Not AvailableWithdrawnPreventionRespiratory Complications / Swallowing Disorders1
Not AvailableWithdrawnPreventionVaginal Delivery1
Not AvailableWithdrawnSupportive CarePain NOS / Traumas1
Not AvailableWithdrawnTreatmentFull Term Pregnant Patients / Undergoing Lower Segment Caesarian Section1

Pharmacoeconomics

Manufacturers
  • Ortho mcneil janssen pharmaceuticals inc
  • Actavis southatlantic llc
  • Lavipharm laboratories inc
  • Mylan technologies inc
  • Noven pharmaceuticals inc
  • Teva pharmaceuticals usa
  • Watson laboratories inc
  • Meda pharmaceuticals inc
  • Abbott laboratories hosp products div
  • Hospira inc
  • Baxter healthcare corp anesthesia and critical care
  • Marsam pharmaceuticals llc
  • Akorn inc
  • Cephalon inc
  • Barr laboratories inc
  • Mallinckrodt inc
  • Incline therapeutics inc
  • Abbott laboratories
Packagers
  • 4uOrtho LLC
  • Actavis Group
  • Akorn Inc.
  • Alza Corp.
  • Anesta Corp.
  • Apotex Inc.
  • Aveva Drug Delivery Systems Inc.
  • B&B Pharmaceuticals
  • Barr Pharmaceuticals
  • Baxter International Inc.
  • Cephalon Inc.
  • Chattem Chemicals Inc.
  • Cima Laboratories Inc.
  • Corium International Inc.
  • DAVA Pharmaceuticals
  • Dispensing Solutions
  • Hospira Inc.
  • Janssen-Ortho Inc.
  • LTS Lohmann Therapy Systems Corp.
  • Mallinckrodt Inc.
  • Meda AB
  • Medisca Inc.
  • Mylan
  • Nucare Pharmaceuticals Inc.
  • Ortho Mcneil Janssen Pharmaceutical Inc.
  • Pharmakon
  • Pharmedium
  • Physicians Total Care Inc.
  • Quality Care
  • Sandoz
  • Stat Rx Usa
  • Taylor Pharmaceuticals
  • Teva Pharmaceutical Industries Ltd.
  • Watson Pharmaceuticals
Dosage forms
FormRouteStrength
TabletSublingual100 ug/1
TabletSublingual100 mcg
TabletSublingual200 ug/1
TabletSublingual200 mcg
TabletSublingual300 mcg
TabletSublingual300 ug/1
TabletSublingual400 ug/1
TabletSublingual400 mcg
TabletSublingual600 mcg
TabletSublingual600 ug/1
TabletSublingual800 ug/1
TabletSublingual800 mcg
Tablet, orally disintegratingSublingual100 ug/1
Tablet, orally disintegratingSublingual200 ug/1
Tablet, orally disintegratingSublingual300 ug/1
Tablet, orally disintegratingSublingual400 ug/1
Tablet, orally disintegratingSublingual600 ug/1
Tablet, orally disintegratingSublingual800 ug/1
Patch, extended releaseTransdermal12.5 ug/1h
TabletBuccal100 micrograms
TabletBuccal200 micrograms
TabletBuccal400 micrograms
TabletBuccal600 micrograms
TabletBuccal800 micrograms
PatchTransdermal1.28 mg/1[USP'U]
PatchTransdermal10.20 mg/1[USP'U]
PatchTransdermal12 ug/1
PatchTransdermal12 ug/1h
PatchTransdermal12.5 ug/1h
PatchTransdermal2.55 mg/1[USP'U]
PatchTransdermal37.5 ug/1h
PatchTransdermal5.10 mg/1[USP'U]
PatchTransdermal62.5 ug/1h
PatchTransdermal7.65 mg/1[USP'U]
PatchTransdermal87.5 ug/1h
Patch, extended releaseTransdermal100 ug/1h
Patch, extended releaseTransdermal100 ug/72h
Patch, extended releaseTransdermal12 ug/1h
Patch, extended releaseTransdermal2.5 mg/72h
Patch, extended releaseTransdermal25 ug/72h
Patch, extended releaseTransdermal25 ug/1h
Patch, extended releaseTransdermal37.5 ug/1h
Patch, extended releaseTransdermal5.0 mg/72h
Patch, extended releaseTransdermal50 ug/1h
Patch, extended releaseTransdermal50 ug/72h
Patch, extended releaseTransdermal62.5 ug/1h
Patch, extended releaseTransdermal7.5 mg/72h
Patch, extended releaseTransdermal75 ug/1h
Patch, extended releaseTransdermal87.5 ug/1h
TabletBuccal; Sublingual100 ug/1
TabletBuccal; Sublingual200 ug/1
TabletBuccal; Sublingual400 ug/1
TabletBuccal; Sublingual600 ug/1
TabletBuccal; Sublingual800 ug/1
TabletBuccal; Oral; Transmucosal100 ug/1
TabletBuccal; Oral; Transmucosal200 ug/1
TabletBuccal; Oral; Transmucosal400 ug/1
TabletBuccal; Oral; Transmucosal600 ug/1
TabletBuccal; Oral; Transmucosal800 ug/1
InjectionIntramuscular; Intravenous50 ug/1mL
InjectionIntravenous50 ug/1mL
Injection, solutionEpidural; Intravenous10 ug/1mL
Injection, solutionIntravenous20 ug/1mL
Injection, solutionIntravenous25 ug/1mL
Injection, solutionIntravenous5 ug/1mL
Injection, solutionIntravenous50 ug/1mL
LozengeOral; Transmucosal1200 ug/1
LozengeOral; Transmucosal1600 ug/1
LozengeOral; Transmucosal200 ug/1
LozengeOral; Transmucosal800 ug/1
LozengeTransmucosal1200 ug/1
LozengeTransmucosal1600 ug/1
LozengeTransmucosal200 ug/1
LozengeTransmucosal400 ug/1
LozengeTransmucosal600 ug/1
LozengeTransmucosal800 ug/1
SolutionEpidural; Intramuscular; Intravenous50 mcg
LiquidEpidural; Intramuscular; Intravenous50 mcg
Injection, solutionEpidural
PatchTransdermal100 ug/1
PatchTransdermal12.5 ug/1
PatchTransdermal25 ug/1
PatchTransdermal50 ug/1
PatchTransdermal75 ug/1
PatchTransdermal100 ug/1h
PatchTransdermal25 ug/1h
PatchTransdermal50 ug/1h
PatchTransdermal75 ug/1h
Patch, extended releaseTransdermal100 mcg
Patch, extended releaseTransdermal25 mcg
Patch, extended releaseTransdermal50 mcg
Patch, extended releaseTransdermal75 mcg
TabletBuccal; Oral; Transmucosal300 ug/1
Tablet, effervescentBuccal; Sublingual100 mcg
Tablet, effervescentBuccal; Sublingual200 mcg
Tablet, effervescentBuccal; Sublingual400 mcg
Tablet, effervescentBuccal; Sublingual600 mcg
Tablet, effervescentBuccal; Sublingual800 mcg
LiquidIntramuscular; Intravenous
SolutionNasal100 mcg
SolutionNasal200 mcg
SolutionNasal50 mcg
PatchTransdermal40 ug/1
PatchTransdermal40 μg/dose
Patch, extended release, electrically controlledTransdermal40 ug/10min
Aerosol, sprayNasal100 ug/81
Aerosol, sprayNasal300 ug/81
Aerosol, sprayNasal400 ug/81
SprayNasal100 ug/1
SprayNasal300 ug/1
SprayNasal400 ug/1
Film, solubleBuccal1200 mcg
Film, solubleBuccal1200 ug/1
Film, solubleBuccal200 mcg
Film, solubleBuccal200 ug/1
Film, solubleBuccal400 mcg
Film, solubleBuccal400 ug/1
Film, solubleBuccal600 mcg
Film, solubleBuccal600 ug/1
Film, solubleBuccal800 mcg
Film, solubleBuccal800 ug/1
PatchTransdermal12.0 mcg
PatchTransdermal10 mg
PatchTransdermal2.5 mg
PatchTransdermal5 mg
PatchTransdermal7.5 mg
PatchTransdermal37 mcg
Injection, solutionIntramuscular; Intravenous50 ug/1mL
SpraySublingual0.1 mg/1
SpraySublingual0.2 mg/1
SpraySublingual0.4 mg/1
SpraySublingual0.6 mg/1
SpraySublingual0.8 mg/1
PatchTransdermal100 mcg
PatchTransdermal12 mcg
PatchTransdermal25 mcg
PatchTransdermal50 mcg
PatchTransdermal75 mcg
LozengeOral; Transmucosal1200 1/1
LozengeOral; Transmucosal400 ug/1
LozengeOral; Transmucosal600 ug/1
Prices
Unit descriptionCostUnit
Fentanyl base powder1498.18USD g
Fentanyl citrate powder1062.5USD g
Duragesic-100 5 100 mcg/hr Patches Box411.59USD box
Duragesic-75 5 75 mcg/hr Patches Box318.93USD box
Fentanyl 5 100 mcg/hr Patches Box210.0USD box
Duragesic-50 5 50 mcg/hr Patches Box205.78USD box
Actiq 1600 mcg lozenge150.29USD lozenge
Fentanyl 5 50 mcg/hr Patches Box129.99USD box
Actiq 1200 mcg lozenge121.82USD lozenge
Actiq 1600 mcg Lollipop119.42USD lollipop
Duragesic-25 5 25 mcg/hr Patches Box114.42USD box
Duragesic-12 5 12 mcg/hr Patches Box95.99USD box
Actiq 800 mcg lozenge93.76USD lozenge
Actiq 1200 mcg Lollipop85.7USD lollipop
Duragesic 100 mcg/hr patch81.36USD patch
Actiq 600 mcg lozenge79.16USD lozenge
Actiq 800 mcg Lollipop75.98USD lollipop
Fentanyl 5 12 (12.5)mcg/hr Patches Box67.99USD box
Fentanyl 5 25 mcg/hr Patches Box66.66USD box
Actiq 600 mcg Lollipop65.13USD lollipop
Actiq 400 mcg lozenge64.62USD lozenge
Fentanyl 100 mcg/hr patch61.69USD patch
Duragesic 75 mcg/hr patch61.3USD patch
Fentora 800 mcg buccal tablet54.77USD tablet
Actiq 400 mcg Lollipop53.75USD lollipop
Actiq 200 mcg lozenge51.05USD lozenge
Fentora 600 mcg buccal tablet47.37USD tablet
Fentanyl 75 mcg/hr patch46.48USD patch
Actiq 200 mcg Lollipop42.14USD lollipop
Duragesic 50 mcg/hr patch40.19USD patch
FentaNYL Citrate 1600 mcg Lollipop38.53USD lollipop
Fentora 400 mcg buccal tablet34.24USD tablet
Fentanyl 50 mcg/hr patch30.47USD patch
FentaNYL Citrate 1200 mcg Lollipop30.0USD lollipop
Fentora 300 mcg buccal tablet28.84USD tablet
Fentora 200 mcg buccal tablet23.57USD tablet
Duragesic 25 mcg/hr patch21.98USD patch
FentaNYL Citrate 400 mcg Lollipop20.0USD lollipop
Fentora 100 mcg buccal tablet18.64USD tablet
Duragesic 12 mcg/hr patch18.21USD patch
Fentanyl 25 mcg/hr patch16.67USD patch
Fentanyl 12 mcg/hr patch13.8USD patch
Fentanyl 0.05 mg/ml vial1.96USD ml
Fentanyl cit 1500 mcg/30 ml1.44USD ml
Fentanyl-ns 50 mcg/ml syringe1.0USD ml
Fentanyl-ns 300 mcg/30 ml syr0.99USD ml
Fentanyl-ns 20 mcg/ml syringe0.72USD ml
Fentanyl-ns 10 mcg/ml syringe0.64USD ml
Fentanyl cit 2750 mcg/55 ml0.35USD ml
Fentanyl-ns 500 mcg/50 ml syr0.31USD ml
Sublimaze 0.05 mg/ml ampul0.23USD ml
Fentanyl 0.05 mg/ml ampul0.21USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6317629No1995-06-022012-06-02Us
US6200604No1999-03-262019-03-26Us
US6974590No1999-03-262019-03-26Us
US8728441No1999-03-262019-03-26Us
US8753611No1999-03-262019-03-26Us
US8765100No1999-03-262019-03-26Us
US7862833No2008-06-152028-06-15Us
US8119158No2004-12-302024-12-30Us
US8092832No2004-12-302024-12-30Us
US7862832No2008-06-152028-06-15Us
US6761910No1999-09-242019-09-24Us
US6195582No1999-01-282019-01-28Us
US6881208No2002-04-192022-04-19Us
US8428709No2012-06-112032-06-11Us
US8428708No2012-05-212032-05-21Us
US6169920No1998-01-022018-01-02Us
US8781571No2012-03-312032-03-31Us
US6181963No1999-11-022019-11-02Us
US5843014No1995-12-012015-12-01Us
US5697896No1996-12-162016-12-16Us
US6975902No2004-04-012024-04-01Us
US8301238No2011-09-302031-09-30Us
US9095706No2013-02-032033-02-03Us
US7579019No2000-01-222020-01-22Us
US6159498No1996-10-182016-10-18Us
US6759059No1999-09-242019-09-24Us
US7910132No1999-09-242019-09-24Us
US8889176No2004-01-162024-01-16Us
US6432440No1998-04-202018-04-20Us
US8216604No2004-10-032024-10-03Us
US9078814No2004-01-082024-01-08Us
US8486973No2010-04-272030-04-27Us
US8835460No2007-01-252027-01-25Us
US8835459No2007-01-252027-01-25Us
US9241935No2007-01-252027-01-25Us
US8486972No2010-04-272030-04-27Us
US9364656No2011-09-302031-09-30Us
US9597288No2007-07-232027-07-23Us
US9642844No2007-01-252027-01-25Us
US9289387No2007-01-252027-01-25Us
US9642797No2007-01-252027-01-25Us
US9731869No2012-01-262032-01-26Us
US9731121No2011-10-172031-10-17Us
US9814705No2004-01-082024-01-08Us
US10016403No2007-01-252027-01-25Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)83-84 US. Patent 3,141,823.
water solubility200 mg/L (at 25 °C)ROY,SD & FLYNN,GL (1988)
logP4.05SANGSTER (1993)
Predicted Properties
PropertyValueSource
Water Solubility0.024 mg/mLALOGPS
logP4.12ALOGPS
logP3.82ChemAxon
logS-4.2ALOGPS
pKa (Strongest Basic)8.77ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area23.55 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity103.48 m3·mol-1ChemAxon
Polarizability40.03 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9766
Blood Brain Barrier+0.9901
Caco-2 permeable+0.6459
P-glycoprotein substrateSubstrate0.6082
P-glycoprotein inhibitor IInhibitor0.7161
P-glycoprotein inhibitor IINon-inhibitor0.8371
Renal organic cation transporterInhibitor0.5824
CYP450 2C9 substrateNon-substrate0.7879
CYP450 2D6 substrateNon-substrate0.9117
CYP450 3A4 substrateSubstrate0.5856
CYP450 1A2 substrateNon-inhibitor0.7715
CYP450 2C9 inhibitorNon-inhibitor0.873
CYP450 2D6 inhibitorNon-inhibitor0.6327
CYP450 2C19 inhibitorNon-inhibitor0.5724
CYP450 3A4 inhibitorNon-inhibitor0.8218
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.7346
Ames testNon AMES toxic0.8417
CarcinogenicityNon-carcinogens0.8536
BiodegradationNot ready biodegradable0.8554
Rat acute toxicity3.9836 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.796
hERG inhibition (predictor II)Inhibitor0.6791
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-0002-9850000000-7ce3a6f35f5dee98185f
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000i-0009000000-62593b54c6285a566893
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000i-0209000000-d550d803c25d31570227
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000i-0901000000-09bd125eea134f8811a4
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000i-0900000000-2c34993eade063cb426f
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-001r-0900000000-beb72ea99dc9c125d29b
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-000i-0009000000-bf70e4d857c26d30032f
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-000i-0907000000-a9f5d0c422eff1474d38
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-000i-0900000000-0c03ba9ef576114a9503
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0a4i-0900000000-d2a36b402c3a7424fab6
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0a4i-1900000000-e0cbdfad80c306baabc1
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0a4i-2900000000-ea551550ac6cbe6d3960
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0pdi-8900000000-89b1a77e558ec74cf3ac
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0kdj-9400000000-358833c028a079789d0b
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0ufs-9200000000-ff2c211a084a5f124781

Taxonomy

Description
This compound belongs to the class of organic compounds known as fentanyls. These are compounds containing the fentanyl moiety or a derivative, which is based on a N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide skeleton.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Piperidines
Sub Class
Fentanyls
Direct Parent
Fentanyls
Alternative Parents
Phenethylamines / Anilides / Aralkylamines / Tertiary carboxylic acid amides / Trialkylamines / Amino acids and derivatives / Azacyclic compounds / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives
show 1 more
Substituents
Fentanyl / Phenethylamine / Anilide / Aralkylamine / Monocyclic benzene moiety / Benzenoid / Tertiary carboxylic acid amide / Amino acid or derivatives / Carboxamide group / Tertiary amine
show 13 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
piperidines, monocarboxylic acid amide, anilide (CHEBI:119915)

Targets

Details
1. Mu-type opioid receptor
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Voltage-gated calcium channel activity
Specific Function
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone...
Gene Name
OPRM1
Uniprot ID
P35372
Uniprot Name
Mu-type opioid receptor
Molecular Weight
44778.855 Da
References
  1. You HJ, Colpaert FC, Arendt-Nielsen L: The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes. Exp Neurol. 2005 Jan;191(1):174-83. [PubMed:15589524]
  2. Scott LJ, Perry CM: Remifentanil: a review of its use during the induction and maintenance of general anaesthesia. Drugs. 2005;65(13):1793-823. [PubMed:16114980]
  3. Scott LJ, Perry CM: Spotlight on remifentanil for general anaesthesia. CNS Drugs. 2005;19(12):1069-74. [PubMed:16332149]
  4. Dosen-Micovic L, Ivanovic M, Micovic V: Steric interactions and the activity of fentanyl analogs at the mu-opioid receptor. Bioorg Med Chem. 2006 May 1;14(9):2887-95. Epub 2006 Jan 11. [PubMed:16376082]
  5. Dardonville C, Fernandez-Fernandez C, Gibbons SL, Ryan GJ, Jagerovic N, Gabilondo AM, Meana JJ, Callado LF: Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites. Bioorg Med Chem. 2006 Oct 1;14(19):6570-80. Epub 2006 Jun 23. [PubMed:16797997]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  7. Hajiha M, DuBord MA, Liu H, Horner RL: Opioid receptor mechanisms at the hypoglossal motor pool and effects on tongue muscle activity in vivo. J Physiol. 2009 Jun 1;587(Pt 11):2677-92. doi: 10.1113/jphysiol.2009.171678. Epub 2009 Apr 29. [PubMed:19403616]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Opioid receptor activity
Specific Function
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine n...
Gene Name
OPRD1
Uniprot ID
P41143
Uniprot Name
Delta-type opioid receptor
Molecular Weight
40368.235 Da
References
  1. Rodrigues AR, Castro MS, Francischi JN, Perez AC, Duarte ID: Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats. Braz J Med Biol Res. 2005 Jan;38(1):91-7. Epub 2005 Jan 18. [PubMed:15665994]
  2. Poonawala T, Levay-Young BK, Hebbel RP, Gupta K: Opioids heal ischemic wounds in the rat. Wound Repair Regen. 2005 Mar-Apr;13(2):165-74. [PubMed:15828941]
  3. Sahin AS, Duman A, Atalik EK, Ogun CO, Sahin TK, Erol A, Ozergin U: The mechanisms of the direct vascular effects of fentanyl on isolated human saphenous veins in vitro. J Cardiothorac Vasc Anesth. 2005 Apr;19(2):197-200. [PubMed:15868528]
  4. Darwish M, Tempero K, Kirby M, Thompson J: Pharmacokinetics and dose proportionality of fentanyl effervescent buccal tablets in healthy volunteers. Clin Pharmacokinet. 2005;44(12):1279-86. [PubMed:16372825]
  5. Darwish M, Kirby M, Robertson P Jr, Tracewell W, Jiang JG: Pharmacokinetic properties of fentanyl effervescent buccal tablets: a phase I, open-label, crossover study of single-dose 100, 200, 400, and 800 microg in healthy adult volunteers. Clin Ther. 2006 May;28(5):707-14. [PubMed:16861092]
  6. Hajiha M, DuBord MA, Liu H, Horner RL: Opioid receptor mechanisms at the hypoglossal motor pool and effects on tongue muscle activity in vivo. J Physiol. 2009 Jun 1;587(Pt 11):2677-92. doi: 10.1113/jphysiol.2009.171678. Epub 2009 Apr 29. [PubMed:19403616]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Opioid receptor activity
Specific Function
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synt...
Gene Name
OPRK1
Uniprot ID
P41145
Uniprot Name
Kappa-type opioid receptor
Molecular Weight
42644.665 Da
References
  1. Pascoe JE, Williams KL, Mukhopadhyay P, Rice KC, Woods JH, Ko MC: Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys. Psychoneuroendocrinology. 2008 May;33(4):478-86. doi: 10.1016/j.psyneuen.2008.01.006. Epub 2008 Mar 5. [PubMed:18325678]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Wandel C, Kim R, Wood M, Wood A: Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology. 2002 Apr;96(4):913-20. [PubMed:11964599]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Wandel C, Kim R, Wood M, Wood A: Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology. 2002 Apr;96(4):913-20. [PubMed:11964599]

Drug created on June 13, 2005 07:24 / Updated on November 14, 2018 12:46