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Properties

Spectra

Taxonomy

Ipratropium

Targets (3)Enzymes (2)Transporters (2)Biointeractions (7)

Identification

Name

Ipratropium

Accession Number

DB00332 (APRD00537)

Type

Small Molecule

Groups

Approved

Description

A muscarinic antagonist structurally related to atropine but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.

Structure

Similar Structures

Synonyms

Ipratropium cation
Ipratropium ion

Product Ingredients

Ingredient	UNII	CAS	InChI Key
Ipratropium bromide	VJV4X1P2Z1	22254-24-6	LHLMOSXCXGLMMN-WDTICOSOSA-M
Ipratropium bromide monohydrate	J697UZ2A9J	66985-17-9	KEWHKYJURDBRMN-XSAPEOHZSA-M
Ipratropium chloride	Not Available	Not Available	MQIPRYDNKGFOGV-WDTICOSOSA-M

Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Atrovent	Spray, metered	42 ug/1	Nasal	Remedy Repack	2014-05-28	2018-03-15
Atrovent	Spray, metered	21 ug/1	Nasal	Physicians Total Care, Inc.	2006-03-31	Not applicable
Atrovent	Solution	250 mcg	Respiratory (inhalation)	Boehringer Ingelheim (Canada) Ltd Ltee	1988-12-31	2007-10-11
Atrovent	Spray, metered	42 ug/1	Nasal	Boehringer Ingelheim	1996-01-01	Not applicable
Atrovent	Spray, metered	21 ug/1	Nasal	Boehringer Ingelheim	1996-01-01	Not applicable
Atrovent HFA	Aerosol, metered	17 ug/1	Respiratory (inhalation)	Boehringer Ingelheim	2005-05-01	Not applicable
Atrovent HFA	Aerosol, metered	17 ug/1	Respiratory (inhalation)	A S Medication Solutions	2005-05-01	2017-06-20
Atrovent HFA	Aerosol, metered	20 mcg	Respiratory (inhalation)	Boehringer Ingelheim (Canada) Ltd Ltee	2004-03-24	Not applicable
Atrovent Nasal Aerosol 20mcg/aem	Aerosol	20 mcg	Nasal; Respiratory (inhalation)	Boehringer Ingelheim (Canada) Ltd Ltee	1989-12-31	1999-08-09
Atrovent Nasal Spray	Solution	21 mcg	Nasal	Sanofi Aventis	1995-12-31	Not applicable

Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Apo-ipravent Solution - Inh 250mcg/ml	Solution	250 mcg	Respiratory (inhalation)	Apotex Corporation	1994-12-31	Not applicable
Apo-ipravent Sterules	Solution	250 mcg	Respiratory (inhalation)	Apotex Corporation	1998-07-09	Not applicable
Apo-ipravent Sterules	Solution	125 mcg	Respiratory (inhalation)	Apotex Corporation	2001-08-28	Not applicable
Dom-ipratropium	Solution	21 mcg	Nasal	Dominion Pharmacal	1999-09-15	Not applicable
Dom-ipratropium 125 Mcg/ml	Liquid	125 mcg	Respiratory (inhalation)	Dominion Pharmacal	Not applicable	Not applicable
Dom-ipratropium 250 Mcg/ml (1 Ml)	Liquid	250 mcg	Respiratory (inhalation)	Dominion Pharmacal	Not applicable	Not applicable
Dom-ipratropium 250 Mcg/ml (2 Ml)	Liquid	250 mcg	Respiratory (inhalation)	Dominion Pharmacal	Not applicable	Not applicable
Dom-ipratropium 250 Mcg/ml (20 Ml)	Liquid	250 mcg	Respiratory (inhalation)	Dominion Pharmacal	Not applicable	Not applicable
Ipratropium Bromide	Solution	.5 mg/2.5mL	Respiratory (inhalation)	Unit Dose Services	2011-03-01	Not applicable
Ipratropium Bromide	Solution	.5 mg/2.5mL	Respiratory (inhalation)	A S Medication Solutions	2011-03-01	2017-06-20

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Apo-salvent-ipravent Sterules	Ipratropium (0.5 mg) + Salbutamol (2.5 mg)	Solution	Respiratory (inhalation)	Apotex Corporation	2006-08-25	Not applicable
Combivent Inhalation Aerosol	Ipratropium (20 mcg) + Salbutamol sulfate (120 mcg)	Aerosol, metered	Oral; Respiratory (inhalation)	Boehringer Ingelheim (Canada) Ltd Ltee	1995-12-31	2007-10-02
Combivent Respimat	Ipratropium (20 ug/1) + Salbutamol sulfate (120 ug/1)	Spray, metered	Respiratory (inhalation)	Boehringer Ingelheim	2012-07-01	Not applicable
Combivent Respimat	Ipratropium (20 mcg) + Salbutamol (100 mcg)	Solution	Respiratory (inhalation)	Boehringer Ingelheim (Canada) Ltd Ltee	2014-09-16	Not applicable
Combivent Udv	Ipratropium (0.2 mg) + Salbutamol (1 mg)	Solution	Respiratory (inhalation)	Boehringer Ingelheim (Canada) Ltd Ltee	1997-07-25	Not applicable
DuoNeb	Ipratropium (.5 mg/3mL) + Salbutamol sulfate (2.5 mg/3mL)	Solution	Respiratory (inhalation)	Mylan Specialty	2011-02-15	2016-10-13
Duovent Udv	Ipratropium (0.125 mg) + Fenoterol hydrobromide (0.3125 mg)	Solution	Oral; Respiratory (inhalation)	Boehringer Ingelheim (Canada) Ltd Ltee	1995-12-31	2017-01-31
Ipramol	Ipratropium (0.5 mg) + Salbutamol (2.5 mg)	Solution	Respiratory (inhalation)	Ivax Pharmaceuticals Incorporated	Not applicable	Not applicable
Ipratropium Bromide and Albuterol Sulfate	Ipratropium (.5 mg/3mL) + Salbutamol sulfate (2.5 mg/3mL)	Solution	Respiratory (inhalation)	A S Medication Solutions	2013-05-13	2017-06-20
Ipratropium Bromide and Albuterol Sulfate	Ipratropium (.5 mg/3mL) + Salbutamol sulfate (2.5 mg/3mL)	Solution	Respiratory (inhalation)	Mylan Pharmaceuticals	2013-03-01	Not applicable

International/Other Brands

Aerovent (Teva) / Apovent (Apotex Inc.) / Atronase (Boehringer Ingelheim) / Ipraxa (Ivax) / Ipvent (Cipla Medpro) / Rhinovent (Boehringer Ingelheim) / Rinatec (Boehringer Ingelheim) / Rinovagos (Valeas)

Categories

UNII

GR88G0I6UL

CAS number

60205-81-4

Weight

Average: 332.463
Monoisotopic: 332.22202025

Chemical Formula

C₂₀H₃₀NO₃

InChI Key

OEXHQOGQTVQTAT-BHIXFJMTSA-N

InChI

InChI=1S/C20H30NO3/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15/h4-8,14,16-19,22H,9-13H2,1-3H3/q+1/t16-,17+,18+,19?,21?

IUPAC Name

(1R,3R,5S)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-(propan-2-yl)-8-azabicyclo[3.2.1]octan-8-ium

SMILES

[H][C@]12CC[C@]([H])(C[C@@H](C1)OC(=O)C(CO)C1=CC=CC=C1)[N+]2(C)C(C)C

Pharmacology

Indication

For maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.

Associated Conditions

Pharmacodynamics

Ipratropium bromide, a synthetic ammonium compound structurally similar to atropine, is used as a bronchodilator in the management of cholinergic-mediated bronchospasm associated with chronic obstructive pulmonary disease and in the treatment of rhinorrhea associated with the common cold or with allergic or nonallergic seasonal rhinitis.

Mechanism of action

Ipratropium bromide is an anticholinergic agent. It blocks muscarinic cholinergic receptors, without specificity for subtypes, resulting in a decrease in the formation of cyclic guanosine monophosphate (cGMP). Most likely due to actions of cGMP on intracellular calcium, this results in decreased contractility of smooth muscle.

Target	Actions	Organism
AMuscarinic acetylcholine receptor M1	antagonist	Human
AMuscarinic acetylcholine receptor M2	antagonist	Human
AMuscarinic acetylcholine receptor M3	antagonist	Human

Absorption

Inhalation (local)-minimal; Nasal-rapid and minimal

Volume of distribution

4.6 L/kg

Protein binding

Minimally (0 to 9% in vitro) bound to plasma albumin and α1-acid glycoproteins

Metabolism

Partially metabolized to at least 8 metabolites formed primarily via hydrolysis and conjugation. The main metabolites are N-isopropylnortropium methobromide, which is formed by enzymatic hydrolysis of the ester; α-phenylacrylic acid-N-isopropylnortropine-ester methobromide, which is formed by enzymatic loss of a water; and phenylacetic acid-N-isopropylnortropine-ester methobromide, which is formed by enzymatic loss of a CH₃OH-group. These metabolites appear to be inactive.

Route of elimination

Primarily eliminated renally via active secretion.

Half life

2-4 hours after administration orally, IV or by oral inhalation (radiolabeled ipratropium bromide assay measures parent drug and its metabolites). Using a radioreceptor assay that measures only unchanged ipratropium bromide, the initial distribution-phase half-life (t_{1/2 α}) and terminal elimination-phase half-life (t_{1/2 β}) were 0.07 and 1.6 hours, respectively, following a single 2 mg IV dose of the drug in healthy adults.

Clearance

2.3 L/min (total clearance of active ingredient)

Toxicity

LD₅₀=1001mg/kg (orally in mice)

Affected organisms

Humans and other mammals

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
1,10-Phenanthroline	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with 1,10-Phenanthroline.	Experimental
Abiraterone	The serum concentration of Ipratropium bromide can be increased when it is combined with Abiraterone.	Approved
Acetyl sulfisoxazole	The metabolism of Ipratropium bromide can be decreased when combined with Acetyl sulfisoxazole.	Approved, Vet Approved
Aclidinium	Ipratropium bromide may increase the anticholinergic activities of Aclidinium.	Approved
Alcuronium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Alcuronium.	Experimental
Alfentanil	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Alfentanil.	Approved, Illicit
Alphacetylmethadol	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Alphacetylmethadol.	Experimental, Illicit
Alphaprodine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Alphaprodine.	Illicit
Ambenonium	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Ambenonium.	Approved
Amiodarone	The metabolism of Ipratropium bromide can be decreased when combined with Amiodarone.	Approved, Investigational
Amoxapine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Amoxapine.	Approved
Anisotropine Methylbromide	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Anisotropine Methylbromide.	Approved
Apalutamide	The serum concentration of Ipratropium bromide can be decreased when it is combined with Apalutamide.	Approved, Investigational
Aprepitant	The serum concentration of Ipratropium bromide can be increased when it is combined with Aprepitant.	Approved, Investigational
Artemether	The metabolism of Ipratropium bromide can be decreased when combined with Artemether.	Approved
Atazanavir	The metabolism of Ipratropium bromide can be decreased when combined with Atazanavir.	Approved, Investigational
Atomoxetine	The metabolism of Ipratropium bromide can be decreased when combined with Atomoxetine.	Approved
Atracurium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Atracurium.	Approved, Experimental, Investigational
Atracurium besylate	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Atracurium besylate.	Approved
Atropine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Atropine.	Approved, Vet Approved
Benactyzine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Benactyzine.	Withdrawn
Bendroflumethiazide	The serum concentration of Bendroflumethiazide can be increased when it is combined with Ipratropium bromide.	Approved
Benzatropine	The risk or severity of adverse effects can be increased when Benzatropine is combined with Ipratropium bromide.	Approved
Benzthiazide	The serum concentration of Benzthiazide can be increased when it is combined with Ipratropium bromide.	Approved
Betaxolol	The metabolism of Ipratropium bromide can be decreased when combined with Betaxolol.	Approved, Investigational
Bezitramide	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Bezitramide.	Experimental, Illicit, Withdrawn
Biperiden	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Biperiden.	Approved, Investigational
Boceprevir	The metabolism of Ipratropium bromide can be decreased when combined with Boceprevir.	Approved, Withdrawn
Bornaprine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Bornaprine.	Experimental
Bortezomib	The metabolism of Ipratropium bromide can be decreased when combined with Bortezomib.	Approved, Investigational
Bosentan	The serum concentration of Ipratropium bromide can be decreased when it is combined with Bosentan.	Approved, Investigational
Botulinum Toxin Type A	Ipratropium bromide may increase the anticholinergic activities of Botulinum Toxin Type A.	Approved, Investigational
Botulinum Toxin Type B	Ipratropium bromide may increase the anticholinergic activities of Botulinum Toxin Type B.	Approved, Investigational
Buprenorphine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Buprenorphine.	Approved, Illicit, Investigational, Vet Approved
Bupropion	The metabolism of Ipratropium bromide can be decreased when combined with Bupropion.	Approved
Butorphanol	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Butorphanol.	Approved, Illicit, Vet Approved
Butylscopolamine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Butylscopolamine.	Approved, Investigational, Vet Approved
Carbamazepine	The metabolism of Ipratropium bromide can be increased when combined with Carbamazepine.	Approved, Investigational
Carfentanil	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Carfentanil.	Illicit, Investigational, Vet Approved
Celecoxib	The metabolism of Ipratropium bromide can be decreased when combined with Celecoxib.	Approved, Investigational
Ceritinib	The serum concentration of Ipratropium bromide can be increased when it is combined with Ceritinib.	Approved
Chloroquine	The metabolism of Ipratropium bromide can be decreased when combined with Chloroquine.	Approved, Investigational, Vet Approved
Chlorothiazide	The serum concentration of Chlorothiazide can be increased when it is combined with Ipratropium bromide.	Approved, Vet Approved
Chlorphenoxamine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Chlorphenoxamine.	Withdrawn
Chlorpromazine	The metabolism of Ipratropium bromide can be decreased when combined with Chlorpromazine.	Approved, Investigational, Vet Approved
Chlorthalidone	The serum concentration of Chlorthalidone can be increased when it is combined with Ipratropium bromide.	Approved
Cholecalciferol	The metabolism of Ipratropium bromide can be decreased when combined with Cholecalciferol.	Approved, Nutraceutical
Cimetidine	The metabolism of Ipratropium bromide can be decreased when combined with Cimetidine.	Approved, Investigational
Cimetropium	Ipratropium bromide may increase the anticholinergic activities of Cimetropium.	Experimental, Investigational
Cinacalcet	The metabolism of Ipratropium bromide can be decreased when combined with Cinacalcet.	Approved
Citalopram	The metabolism of Ipratropium bromide can be decreased when combined with Citalopram.	Approved
Clarithromycin	The metabolism of Ipratropium bromide can be decreased when combined with Clarithromycin.	Approved
Clemastine	The metabolism of Ipratropium bromide can be decreased when combined with Clemastine.	Approved, Investigational
Clobazam	The metabolism of Ipratropium bromide can be decreased when combined with Clobazam.	Approved, Illicit
Clomipramine	The metabolism of Ipratropium bromide can be decreased when combined with Clomipramine.	Approved, Investigational, Vet Approved
Clotrimazole	The metabolism of Ipratropium bromide can be decreased when combined with Clotrimazole.	Approved, Vet Approved
Clozapine	The metabolism of Ipratropium bromide can be decreased when combined with Clozapine.	Approved
Cobicistat	The serum concentration of Ipratropium bromide can be increased when it is combined with Cobicistat.	Approved
Cocaine	The metabolism of Ipratropium bromide can be decreased when combined with Cocaine.	Approved, Illicit
Codeine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Codeine.	Approved, Illicit
Conivaptan	The serum concentration of Conivaptan can be increased when it is combined with Ipratropium bromide.	Approved, Investigational
Coumaphos	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Coumaphos.	Vet Approved
Crizotinib	The metabolism of Ipratropium bromide can be decreased when combined with Crizotinib.	Approved
Curcumin	The metabolism of Ipratropium bromide can be decreased when combined with Curcumin.	Approved, Investigational
Cyclopenthiazide	The serum concentration of Cyclopenthiazide can be increased when it is combined with Ipratropium bromide.	Experimental
Cyclopentolate	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Cyclopentolate.	Approved
Cyclosporine	The metabolism of Ipratropium bromide can be decreased when combined with Cyclosporine.	Approved, Investigational, Vet Approved
Dabrafenib	The serum concentration of Ipratropium bromide can be decreased when it is combined with Dabrafenib.	Approved, Investigational
Darifenacin	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Darifenacin.	Approved, Investigational
Darunavir	The serum concentration of Ipratropium bromide can be increased when it is combined with Darunavir.	Approved
Dasatinib	The serum concentration of Ipratropium bromide can be increased when it is combined with Dasatinib.	Approved, Investigational
Decamethonium	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Decamethonium.	Approved
Deferasirox	The serum concentration of Ipratropium bromide can be decreased when it is combined with Deferasirox.	Approved, Investigational
Delavirdine	The metabolism of Ipratropium bromide can be decreased when combined with Delavirdine.	Approved
Demecarium	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Demecarium.	Approved
Desipramine	The metabolism of Ipratropium bromide can be decreased when combined with Desipramine.	Approved, Investigational
Desloratadine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Desloratadine.	Approved, Investigational
Dexetimide	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dexetimide.	Withdrawn
Dextromoramide	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dextromoramide.	Experimental, Illicit
Dextropropoxyphene	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dextropropoxyphene.	Approved, Illicit, Investigational, Withdrawn
Dezocine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dezocine.	Approved, Investigational
Dichlorvos	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Dichlorvos.	Vet Approved
Dicyclomine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dicyclomine.	Approved
Dihydrocodeine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dihydrocodeine.	Approved, Illicit
Dihydroergotamine	The metabolism of Ipratropium bromide can be decreased when combined with Dihydroergotamine.	Approved, Investigational
Dihydroetorphine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dihydroetorphine.	Experimental, Illicit
Dihydromorphine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dihydromorphine.	Experimental, Illicit
Diltiazem	The metabolism of Ipratropium bromide can be decreased when combined with Diltiazem.	Approved, Investigational
Diphenhydramine	The metabolism of Ipratropium bromide can be decreased when combined with Diphenhydramine.	Approved, Investigational
Diphenoxylate	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Diphenoxylate.	Approved, Illicit
Dipivefrin	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Dipivefrin.	Approved
Distigmine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Distigmine.	Experimental
Donepezil	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Donepezil.	Approved
Dosulepin	The metabolism of Ipratropium bromide can be decreased when combined with Dosulepin.	Approved
Doxycycline	The metabolism of Ipratropium bromide can be decreased when combined with Doxycycline.	Approved, Investigational, Vet Approved
DPDPE	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with DPDPE.	Experimental
Dronabinol	Ipratropium bromide may increase the tachycardic activities of Dronabinol.	Approved, Illicit
Dronedarone	The metabolism of Ipratropium bromide can be decreased when combined with Dronedarone.	Approved
Duloxetine	The metabolism of Ipratropium bromide can be decreased when combined with Duloxetine.	Approved
Echothiophate	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Echothiophate.	Approved
Edrophonium	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Edrophonium.	Approved
Eliglustat	The metabolism of Ipratropium bromide can be decreased when combined with Eliglustat.	Approved
Eluxadoline	Ipratropium bromide may increase the constipating activities of Eluxadoline.	Approved, Investigational
Emepronium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Emepronium.	Experimental
Enzalutamide	The serum concentration of Ipratropium bromide can be decreased when it is combined with Enzalutamide.	Approved
Epitizide	The serum concentration of Epitizide can be increased when it is combined with Ipratropium bromide.	Experimental
Erythromycin	The metabolism of Ipratropium bromide can be decreased when combined with Erythromycin.	Approved, Investigational, Vet Approved
Etanautine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Etanautine.	Experimental
Ethopropazine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Ethopropazine.	Approved
Ethylmorphine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Ethylmorphine.	Approved, Illicit
Etorphine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Etorphine.	Illicit, Vet Approved
Etybenzatropine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Etybenzatropine.	Experimental
Fentanyl	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Fentanyl.	Approved, Illicit, Investigational, Vet Approved
Fenthion	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Fenthion.	Vet Approved
Fesoterodine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Fesoterodine.	Approved
Flavoxate	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Flavoxate.	Approved
Fluconazole	The metabolism of Ipratropium bromide can be decreased when combined with Fluconazole.	Approved, Investigational
Fluoxetine	The metabolism of Ipratropium bromide can be decreased when combined with Fluoxetine.	Approved, Vet Approved
Fluvoxamine	The metabolism of Ipratropium bromide can be decreased when combined with Fluvoxamine.	Approved, Investigational
Fosamprenavir	The metabolism of Ipratropium bromide can be decreased when combined with Fosamprenavir.	Approved
Fosaprepitant	The serum concentration of Ipratropium bromide can be increased when it is combined with Fosaprepitant.	Approved
Fosphenytoin	The metabolism of Ipratropium bromide can be increased when combined with Fosphenytoin.	Approved, Investigational
Fusidic Acid	The serum concentration of Ipratropium bromide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Galantamine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Galantamine.	Approved
Gallamine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Gallamine.	Experimental
Gallamine Triethiodide	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Gallamine Triethiodide.	Approved
Ginkgo biloba	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Ginkgo biloba.	Approved, Investigational, Nutraceutical
Glucagon recombinant	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Glucagon recombinant.	Approved
Glycopyrronium	Ipratropium bromide may increase the anticholinergic activities of Glycopyrronium.	Approved, Investigational, Vet Approved
Haloperidol	The metabolism of Ipratropium bromide can be decreased when combined with Haloperidol.	Approved
Heroin	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Heroin.	Approved, Illicit, Investigational
Homatropine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Homatropine.	Approved
Human secretin	The therapeutic efficacy of Human secretin can be decreased when used in combination with Ipratropium bromide.	Approved
Huperzine A	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Huperzine A.	Approved, Investigational
Hydrochlorothiazide	The serum concentration of Hydrochlorothiazide can be increased when it is combined with Ipratropium bromide.	Approved, Vet Approved
Hydrocodone	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Hydrocodone.	Approved, Illicit
Hydroflumethiazide	The serum concentration of Hydroflumethiazide can be increased when it is combined with Ipratropium bromide.	Approved, Investigational
Hydromorphone	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Hydromorphone.	Approved, Illicit
Hyoscyamine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Hyoscyamine.	Approved
Idelalisib	The metabolism of Ipratropium bromide can be decreased when combined with Idelalisib.	Approved
Imatinib	The metabolism of Ipratropium bromide can be decreased when combined with Imatinib.	Approved
Imipramine	The metabolism of Ipratropium bromide can be decreased when combined with Imipramine.	Approved
Indapamide	The serum concentration of Indapamide can be increased when it is combined with Ipratropium bromide.	Approved
Indinavir	The metabolism of Ipratropium bromide can be decreased when combined with Indinavir.	Approved
Ipidacrine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Ipidacrine.	Experimental
Isavuconazole	The serum concentration of Ipratropium bromide can be increased when it is combined with Isavuconazole.	Approved, Investigational
Isavuconazonium	The metabolism of Ipratropium bromide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Isoflurophate	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Isoflurophate.	Approved, Investigational, Withdrawn
Isoniazid	The metabolism of Ipratropium bromide can be decreased when combined with Isoniazid.	Approved, Investigational
Isradipine	The metabolism of Ipratropium bromide can be decreased when combined with Isradipine.	Approved, Investigational
Itopride	The therapeutic efficacy of Itopride can be decreased when used in combination with Ipratropium bromide.	Investigational
Itraconazole	The metabolism of Ipratropium bromide can be decreased when combined with Itraconazole.	Approved, Investigational
Ivacaftor	The serum concentration of Ipratropium bromide can be increased when it is combined with Ivacaftor.	Approved
Ketobemidone	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Ketobemidone.	Approved, Investigational
Ketoconazole	The metabolism of Ipratropium bromide can be decreased when combined with Ketoconazole.	Approved, Investigational
Levomethadyl Acetate	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Levomethadyl Acetate.	Approved, Investigational
Levorphanol	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Levorphanol.	Approved
Lofentanil	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Lofentanil.	Illicit
Lopinavir	The metabolism of Ipratropium bromide can be decreased when combined with Lopinavir.	Approved
Lorcaserin	The metabolism of Ipratropium bromide can be decreased when combined with Lorcaserin.	Approved
Lorpiprazole	The serum concentration of Ipratropium bromide can be increased when it is combined with Lorpiprazole.	Approved
Lovastatin	The metabolism of Ipratropium bromide can be decreased when combined with Lovastatin.	Approved, Investigational
Loxapine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Loxapine.	Approved
Luliconazole	The serum concentration of Ipratropium bromide can be increased when it is combined with Luliconazole.	Approved
Lumacaftor	The metabolism of Ipratropium bromide can be increased when combined with Lumacaftor.	Approved
Lumefantrine	The metabolism of Ipratropium bromide can be decreased when combined with Lumefantrine.	Approved
Malathion	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Malathion.	Approved, Investigational
Manidipine	The metabolism of Ipratropium bromide can be decreased when combined with Manidipine.	Approved, Investigational
Mazaticol	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Mazaticol.	Experimental
Mecamylamine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Mecamylamine.	Approved, Investigational
Mefloquine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Mefloquine.	Approved, Investigational
Memantine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Memantine.	Approved, Investigational
Meptazinol	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Meptazinol.	Experimental
Methadone	The metabolism of Ipratropium bromide can be decreased when combined with Methadone.	Approved
Methadyl Acetate	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Methadyl Acetate.	Approved, Illicit
Methanesulfonyl Fluoride	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Methanesulfonyl Fluoride.	Investigational
Methantheline	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Methantheline.	Approved, Investigational
Methotrimeprazine	The metabolism of Ipratropium bromide can be decreased when combined with Methotrimeprazine.	Approved, Investigational
Methscopolamine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Methscopolamine.	Approved
Methyclothiazide	The serum concentration of Methyclothiazide can be increased when it is combined with Ipratropium bromide.	Approved
Methylscopolamine bromide	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Methylscopolamine bromide.	Approved
Metixene	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Metixene.	Approved
Metoclopramide	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Metoclopramide.	Approved, Investigational
Metolazone	The serum concentration of Metolazone can be increased when it is combined with Ipratropium bromide.	Approved
Metoprolol	The metabolism of Ipratropium bromide can be decreased when combined with Metoprolol.	Approved, Investigational
Mianserin	Mianserin may increase the anticholinergic activities of Ipratropium bromide.	Approved, Investigational
Midostaurin	The metabolism of Ipratropium bromide can be decreased when combined with Midostaurin.	Approved, Investigational
Mifepristone	The serum concentration of Ipratropium bromide can be increased when it is combined with Mifepristone.	Approved, Investigational
Minaprine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Minaprine.	Approved
Mirabegron	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Mirabegron.	Approved
Mitotane	The serum concentration of Ipratropium bromide can be decreased when it is combined with Mitotane.	Approved
Morphine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Morphine.	Approved, Investigational
Nabilone	Ipratropium bromide may increase the tachycardic activities of Nabilone.	Approved, Investigational
Nalbuphine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Nalbuphine.	Approved
Nefazodone	The metabolism of Ipratropium bromide can be decreased when combined with Nefazodone.	Approved, Withdrawn
Nelfinavir	The metabolism of Ipratropium bromide can be decreased when combined with Nelfinavir.	Approved
Neostigmine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Neostigmine.	Approved, Vet Approved
Netupitant	The serum concentration of Ipratropium bromide can be increased when it is combined with Netupitant.	Approved, Investigational
Nevirapine	The metabolism of Ipratropium bromide can be increased when combined with Nevirapine.	Approved
Nicardipine	The metabolism of Ipratropium bromide can be decreased when combined with Nicardipine.	Approved, Investigational
Nicomorphine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Nicomorphine.	Experimental
Nilotinib	The metabolism of Ipratropium bromide can be decreased when combined with Nilotinib.	Approved, Investigational
Normethadone	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Normethadone.	Approved, Illicit
Olaparib	The metabolism of Ipratropium bromide can be decreased when combined with Olaparib.	Approved
Opium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Opium.	Approved, Illicit
Orphenadrine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Orphenadrine.	Approved
Osimertinib	The serum concentration of Ipratropium bromide can be increased when it is combined with Osimertinib.	Approved
Otilonium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Otilonium.	Experimental, Investigational
Oxitropium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Oxitropium.	Investigational
Oxybutynin	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Oxybutynin.	Approved, Investigational
Oxycodone	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Oxycodone.	Approved, Illicit, Investigational
Oxymorphone	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Oxymorphone.	Approved, Investigational, Vet Approved
Oxyphenonium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Oxyphenonium.	Approved
Palbociclib	The serum concentration of Ipratropium bromide can be increased when it is combined with Palbociclib.	Approved, Investigational
Pancuronium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Pancuronium.	Approved
Panobinostat	The serum concentration of Ipratropium bromide can be increased when it is combined with Panobinostat.	Approved, Investigational
Paraoxon	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Paraoxon.	Experimental
Paroxetine	The metabolism of Ipratropium bromide can be decreased when combined with Paroxetine.	Approved, Investigational
Peginterferon alfa-2b	The serum concentration of Ipratropium bromide can be decreased when it is combined with Peginterferon alfa-2b.	Approved
Pentazocine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Pentazocine.	Approved, Vet Approved
Pentobarbital	The metabolism of Ipratropium bromide can be increased when combined with Pentobarbital.	Approved, Investigational, Vet Approved
Pentolinium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Pentolinium.	Approved
Pethidine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Pethidine.	Approved
Phenazocine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Phenazocine.	Experimental
Phenglutarimide	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Phenglutarimide.	Experimental
Phenobarbital	The metabolism of Ipratropium bromide can be increased when combined with Phenobarbital.	Approved, Investigational
Phenoperidine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Phenoperidine.	Experimental
Phenytoin	The metabolism of Ipratropium bromide can be increased when combined with Phenytoin.	Approved, Vet Approved
Physostigmine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Physostigmine.	Approved, Investigational
Pipecuronium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Pipecuronium.	Approved
Pirenzepine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Pirenzepine.	Approved
Piritramide	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Piritramide.	Approved, Investigational
Pitolisant	The serum concentration of Ipratropium bromide can be decreased when it is combined with Pitolisant.	Approved, Investigational
Polythiazide	The serum concentration of Polythiazide can be increased when it is combined with Ipratropium bromide.	Approved
Posaconazole	The metabolism of Ipratropium bromide can be decreased when combined with Posaconazole.	Approved, Investigational, Vet Approved
Potassium Chloride	Ipratropium bromide may increase the ulcerogenic activities of Potassium Chloride.	Approved, Withdrawn
Pramlintide	Pramlintide may increase the anticholinergic activities of Ipratropium bromide.	Approved, Investigational
Primidone	The metabolism of Ipratropium bromide can be increased when combined with Primidone.	Approved, Vet Approved
Procyclidine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Procyclidine.	Approved
Promazine	The metabolism of Ipratropium bromide can be decreased when combined with Promazine.	Approved, Vet Approved
Propantheline	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Propantheline.	Approved
Propiverine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Propiverine.	Approved, Investigational
Pyridostigmine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Pyridostigmine.	Approved, Investigational
Quinethazone	The serum concentration of Quinethazone can be increased when it is combined with Ipratropium bromide.	Approved
Quinidine	The metabolism of Ipratropium bromide can be decreased when combined with Quinidine.	Approved, Investigational
Quinine	The metabolism of Ipratropium bromide can be decreased when combined with Quinine.	Approved
Ramosetron	Ipratropium bromide may increase the constipating activities of Ramosetron.	Approved, Investigational
Ranolazine	The metabolism of Ipratropium bromide can be decreased when combined with Ranolazine.	Approved, Investigational
Remifentanil	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Remifentanil.	Approved
Rifabutin	The metabolism of Ipratropium bromide can be increased when combined with Rifabutin.	Approved, Investigational
Rifampicin	The metabolism of Ipratropium bromide can be increased when combined with Rifampicin.	Approved
Rifapentine	The metabolism of Ipratropium bromide can be increased when combined with Rifapentine.	Approved, Investigational
Ritonavir	The metabolism of Ipratropium bromide can be decreased when combined with Ritonavir.	Approved, Investigational
Rivastigmine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Rivastigmine.	Approved, Investigational
Rolapitant	The metabolism of Ipratropium bromide can be decreased when combined with Rolapitant.	Approved, Investigational
Ropinirole	The metabolism of Ipratropium bromide can be decreased when combined with Ropinirole.	Approved, Investigational
Rucaparib	The metabolism of Ipratropium bromide can be decreased when combined with Rucaparib.	Approved, Investigational
Saquinavir	The metabolism of Ipratropium bromide can be decreased when combined with Saquinavir.	Approved, Investigational
Sarilumab	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Sarilumab.	Approved, Investigational
Scopolamine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Scopolamine.	Approved, Investigational
Secretin	The therapeutic efficacy of Secretin can be decreased when used in combination with Ipratropium bromide.	Approved, Investigational
Sertraline	The metabolism of Ipratropium bromide can be decreased when combined with Sertraline.	Approved
Sildenafil	The metabolism of Ipratropium bromide can be decreased when combined with Sildenafil.	Approved, Investigational
Siltuximab	The serum concentration of Ipratropium bromide can be decreased when it is combined with Siltuximab.	Approved, Investigational
Simeprevir	The serum concentration of Ipratropium bromide can be increased when it is combined with Simeprevir.	Approved
Solifenacin	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Solifenacin.	Approved
St. John's Wort	The serum concentration of Ipratropium bromide can be decreased when it is combined with St. John's Wort.	Approved, Investigational, Nutraceutical
Stiripentol	The serum concentration of Ipratropium bromide can be increased when it is combined with Stiripentol.	Approved
Sufentanil	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Sufentanil.	Approved, Investigational
Sulfisoxazole	The metabolism of Ipratropium bromide can be decreased when combined with Sulfisoxazole.	Approved, Vet Approved
Sulpiride	Ipratropium bromide may increase the anticholinergic activities of Sulpiride.	Approved, Investigational
Tacrine	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Tacrine.	Investigational, Withdrawn
Tapentadol	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Tapentadol.	Approved
Telaprevir	The metabolism of Ipratropium bromide can be decreased when combined with Telaprevir.	Approved, Withdrawn
Telithromycin	The metabolism of Ipratropium bromide can be decreased when combined with Telithromycin.	Approved
Terbinafine	The metabolism of Ipratropium bromide can be decreased when combined with Terbinafine.	Approved, Investigational, Vet Approved
Thioridazine	The metabolism of Ipratropium bromide can be decreased when combined with Thioridazine.	Approved, Withdrawn
Ticlopidine	The metabolism of Ipratropium bromide can be decreased when combined with Ticlopidine.	Approved
Tilidine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Tilidine.	Experimental
Tiotropium	Ipratropium bromide may increase the anticholinergic activities of Tiotropium.	Approved
Tipranavir	The metabolism of Ipratropium bromide can be decreased when combined with Tipranavir.	Approved, Investigational
Tocilizumab	The serum concentration of Ipratropium bromide can be decreased when it is combined with Tocilizumab.	Approved
Tolterodine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Tolterodine.	Approved, Investigational
Topiramate	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Topiramate.	Approved
Tramadol	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Tramadol.	Approved, Investigational
Tranylcypromine	The metabolism of Ipratropium bromide can be decreased when combined with Tranylcypromine.	Approved, Investigational
Trichlorfon	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Trichlorfon.	Vet Approved
Trichlormethiazide	The serum concentration of Trichlormethiazide can be increased when it is combined with Ipratropium bromide.	Approved, Vet Approved
Trihexyphenidyl	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Trihexyphenidyl.	Approved
Trimethaphan	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Trimethaphan.	Approved, Investigational
Tropatepine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Tropatepine.	Experimental
Tropicamide	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Tropicamide.	Approved, Investigational
Trospium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Trospium.	Approved
Tubocurarine	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Tubocurarine.	Approved
Tyrothricin	The therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Tyrothricin.	Approved
Umeclidinium	Ipratropium bromide may increase the anticholinergic activities of Umeclidinium.	Approved
Vecuronium	The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Vecuronium.	Approved
Vemurafenib	The serum concentration of Ipratropium bromide can be decreased when it is combined with Vemurafenib.	Approved
Venlafaxine	The metabolism of Ipratropium bromide can be decreased when combined with Venlafaxine.	Approved
Verapamil	The metabolism of Ipratropium bromide can be decreased when combined with Verapamil.	Approved
Voriconazole	The metabolism of Ipratropium bromide can be decreased when combined with Voriconazole.	Approved, Investigational
Ziprasidone	The metabolism of Ipratropium bromide can be decreased when combined with Ziprasidone.	Approved

Food Interactions

Not Available

References

Synthesis Reference

Abdine HH, Belala F, and Al-Badra AA. (2003). Ipratropium bromide: Methods of chemical and biochemical synthesis. In H.G. Brittain (Ed.). Profiles of drug substances, excipients and related methodology (pp. 85-99). Amsterdam, Netherlands: Elsevier Academic Press.

General References

Yamatake Y, Sasagawa S, Yanaura S, Okamiya Y: [Antiallergic asthma effect of ipatropium bromide (Sch 1000) in dogs (author's transl)]. Nihon Yakurigaku Zasshi. 1977 Oct;73(7):785-91. [PubMed:145994]

External Links

Human Metabolome Database: HMDB0014476
KEGG Compound: C07052
PubChem Compound: 657308
PubChem Substance: 46506138
ChemSpider: 19962157
ChEBI: 46659
ChEMBL: CHEMBL1621597
Therapeutic Targets Database: DNC000806
PharmGKB: PA450082
IUPHAR: 325
Guide to Pharmacology: GtP Drug Page
RxList: RxList Drug Page
Drugs.com: Drugs.com Drug Page
Wikipedia: Ipratropium_bromide

ATC Codes

R03BB01 — Ipratropium bromide

R03AL01 — Fenoterol and ipratropium bromide

R01AX03 — Ipratropium bromide

R03AL02 — Salbutamol and ipratropium bromide

AHFS Codes

12:08.08 — Antimuscarinics Antispasmodics

FDA label

Download (88.1 KB)

MSDS

Download (72.7 KB)

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
1	Completed	Basic Science	Pulmonary Disease, Chronic Obstructive	1
1	Completed	Diagnostic	Pulmonary Disease, Chronic Obstructive	1
1	Recruiting	Treatment	Status Asthmaticus	1
2	Completed	Diagnostic	Lung Diseases, Obstructive	1
2	Completed	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	4
2	Completed	Treatment	Parkinson's Disease (PD)	1
2	Completed	Treatment	Pulmonary Disease, Chronic Obstructive	2
2	Not Yet Recruiting	Treatment	Exercise Induced Laryngeal Obstruction (EILO)	1
3	Completed	Prevention	Chronic Lung Diseases / Chronic Obstructive Pulmonary Disease (COPD) / Lung Diseases, Obstructive	1
3	Completed	Treatment	Acute Exacerbation of Chronic Obstructive Pulmonary Disease	1
3	Completed	Treatment	Asthma Bronchial	1
3	Completed	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	1
3	Completed	Treatment	Familial Dysautonomia	1
3	Completed	Treatment	Pulmonary Disease, Chronic Obstructive	8
4	Active Not Recruiting	Treatment	Asthma Bronchial	1
4	Completed	Diagnostic	Asthma Bronchial	1
4	Completed	Supportive Care	Chronic Obstructive Pulmonary Disease (COPD) / Sepsis / Shock	1
4	Completed	Treatment	Acute Asthma / Asthma Bronchial / Reactive Airway Exacerbation	1
4	Completed	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	3
4	Completed	Treatment	Cold	1
4	Completed	Treatment	Exercise-Induced Bronchoconstriction (EIB)	1
4	Completed	Treatment	Pulmonary Disease, Chronic Obstructive	5
4	Recruiting	Treatment	Acute Exacerbation of Chronic Obstructive Pulmonary Disease / Chronic Obstructive Pulmonary Disease (COPD)	1
4	Recruiting	Treatment	Asthma Bronchial	1
4	Terminated	Treatment	Asthma Bronchial	1
4	Unknown Status	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	1
Not Available	Completed	Not Available	Dyspnea / Quadriplegia	1
Not Available	Completed	Not Available	Pulmonary Disease, Chronic Obstructive	6
Not Available	Completed	Not Available	Acute Rhinitis	1
Not Available	Completed	Diagnostic	Chronic Obstructive Pulmonary Disease (COPD)	2
Not Available	Completed	Treatment	Anaesthesia therapy / Extravascular Lung Water / Intensive Care, Surgical / Lung Injury, Acute / Thoracotomy	1
Not Available	Completed	Treatment	Asthma Bronchial	1
Not Available	Completed	Treatment	Bronchitis	1
Not Available	Not Yet Recruiting	Treatment	Asthma Acute / Asthma in Children	1
Not Available	Recruiting	Not Available	Lung Diseases, Interstitial	1
Not Available	Recruiting	Treatment	Asthma Bronchial / Chronic Obstructive Pulmonary Disease (COPD)	1
Not Available	Terminated	Basic Science	Chronic Obstructive Pulmonary Disease (COPD)	1
Not Available	Unknown Status	Not Available	Electrophysiological Parameters / Influence of Nebulized Bronchodilatators on Selected	1
Not Available	Unknown Status	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	1

Pharmacoeconomics

Manufacturers

Boehringer ingelheim pharmaceuticals inc
Actavis mid atlantic llc
Bausch and lomb pharmaceuticals inc
Cobalt laboratories inc
Dey lp
Holopack international corp
Landela pharmaceutical
Nephron corp
Novex pharma
Pharmascience inc
Roxane laboratories inc
Teva parenteral medicines inc
Bausch and lomb inc

Packagers

3M Health Care
Apotex Inc.
A-S Medication Solutions LLC
Automatic Liquid Packaging Inc.
Bausch & Lomb Inc.
Boehringer Ingelheim Ltd.
Cardinal Health
Catalent Pharma Solutions
Cipla Ltd.
Cobalt Pharmaceuticals Inc.
Dey Pharma LP
Dispensing Solutions
Diversified Healthcare Services Inc.
Eon Labs
Holopack International Corp.
Ivax Pharmaceuticals
Medisca Inc.
Mylan
Nephron Pharmaceuticals Corp.
Novex Pharma
Pharmedix
Physicians Total Care Inc.
Redpharm Drug
Roxane Labs
Rx Elite
Sifavitor Srl
Teva Pharmaceutical Industries Ltd.
Watson Pharmaceuticals

Dosage forms

Form	Route	Strength
Solution	Respiratory (inhalation)	250 mcg
Spray, metered	Nasal	21 ug/1
Aerosol, metered	Respiratory (inhalation)	17 ug/1
Aerosol, metered	Respiratory (inhalation)	20 mcg
Aerosol	Nasal; Respiratory (inhalation)	20 mcg
Solution	Nasal	21 mcg
Solution	Nasal	42 mcg
Aerosol, metered	Oral; Respiratory (inhalation)
Spray, metered	Respiratory (inhalation)
Liquid	Respiratory (inhalation)	125 mcg
Liquid	Respiratory (inhalation)	250 mcg
Solution	Oral; Respiratory (inhalation)
Liquid	Respiratory (inhalation)	0.30 mg
Solution	Respiratory (inhalation)	.5 mg/2.5mL
Spray	Nasal	21 ug/1
Spray	Nasal	42 ug/1
Spray, metered	Nasal	42 ug/1
Inhalant	Respiratory (inhalation)
Solution	Respiratory (inhalation)
Solution	Respiratory (inhalation)	.25 mg
Liquid	Respiratory (inhalation)	0.25 mg
Spray, metered	Nasal	21 mcg
Solution	Nasal; Respiratory (inhalation)	250 mcg
Solution	Respiratory (inhalation)	125 mcg

Prices

Unit description	Cost	Unit
Atrovent HFA 17 mcg/act Aerosol 12.9 gm Inhaler	143.59USD	inhaler
Ipratropium bromide powder	100.06USD	g
Atrovent 0.03% Solution 30ml Nasal Spray	96.95USD	bottle
Atrovent 0.06% Solution 15ml Nasal Spray	84.68USD	bottle
Ipratropium Bromide 0.03% Solution 30ml Bottle	53.82USD	bottle
Ipratropium Bromide 0.06% Solution 15ml Bottle	46.14USD	bottle
Ipratropium Bromide 0.02% Solution Each Box Contains Twenty-Five 2.5ml Vials	45.86USD	box
Atrovent hfa inhaler	11.89USD	g
Atrovent 0.06% spray	5.33USD	ml
Atrovent 0.03% spray	3.11USD	ml
Ipratropium 0.06% spray	2.96USD	ml
Ipratropium 0.03% spray	1.73USD	ml
Atrovent 0.03 % Spray	1.04USD	ml
Apo-Ipravent 250 mcg/ml Solution	0.58USD	ml
Mylan-Ipratropium 250 mcg/ml Solution	0.58USD	ml
Novo-Ipramide 250 mcg/ml Solution	0.58USD	ml
Pms-Ipratropium 0.03 % Spray	0.58USD	ml
Pms-Ipratropium 250 mcg/ml Solution	0.58USD	ml
Atrovent Hfa 20 mcg/dose Metered Dose Aerosol	0.1USD	metered dose aerosol

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US5766573	No	1992-11-28	2009-11-28
CA2151383	No	2005-02-08	2013-12-06
US6632842	No	2001-12-28	2021-12-28
US8474447	No	2010-01-17	2030-01-17
US6739333	No	2000-05-26	2020-05-26
US6983743	No	2000-05-26	2020-05-26
US6453795	Yes	1997-06-05	2017-06-05
US8733341	Yes	2011-04-16	2031-04-16
US9027967	Yes	2007-10-01	2027-10-01
US7104470	Yes	1997-04-04	2017-04-04
US7246615	Yes	1996-12-01	2016-12-01
US7896264	Yes	2005-11-26	2025-11-26
US7988001	Yes	2002-02-04	2022-02-04
US7802568	Yes	1999-08-26	2019-08-26
US6149054	Yes	1997-06-16	2017-06-16
US6726124	Yes	1997-04-04	2017-04-04
US7396341	Yes	2007-04-10	2027-04-10
US6846413	Yes	1999-02-28	2019-02-28
US6176442	Yes	1996-12-01	2016-12-01
US7837235	Yes	2008-09-13	2028-09-13
US5964416	Yes	1997-04-04	2017-04-04
US7284474	Yes	2005-02-26	2025-02-26
US6977042	Yes	1999-02-28	2019-02-28
US6988496	Yes	2000-08-23	2020-08-23

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	230-231.5 (bromide)	U.S. Patent 3,505,337
water solubility	Freely soluble	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.00122 mg/mL	ALOGPS
logP	0.89	ALOGPS
logP	-1.8	ChemAxon
logS	-5.5	ALOGPS
pKa (Strongest Acidic)	15.15	ChemAxon
pKa (Strongest Basic)	-2.7	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	46.53 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	105.9 m³·mol^-1	ChemAxon
Polarizability	37.57 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	-	0.9425
Blood Brain Barrier	+	0.8883
Caco-2 permeable	+	0.6619
P-glycoprotein substrate	Substrate	0.5085
P-glycoprotein inhibitor I	Non-inhibitor	0.8489
P-glycoprotein inhibitor II	Non-inhibitor	0.5964
Renal organic cation transporter	Inhibitor	0.6651
CYP450 2C9 substrate	Non-substrate	0.7214
CYP450 2D6 substrate	Non-substrate	0.7637
CYP450 3A4 substrate	Substrate	0.6657
CYP450 1A2 substrate	Non-inhibitor	0.8412
CYP450 2C9 inhibitor	Non-inhibitor	0.9118
CYP450 2D6 inhibitor	Non-inhibitor	0.8915
CYP450 2C19 inhibitor	Non-inhibitor	0.8783
CYP450 3A4 inhibitor	Non-inhibitor	0.9396
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9528
Ames test	Non AMES toxic	0.7112
Carcinogenicity	Non-carcinogens	0.8979
Biodegradation	Ready biodegradable	0.5154
Rat acute toxicity	2.7983 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9596
hERG inhibition (predictor II)	Inhibitor	0.5879

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available

Taxonomy

Classification: Not classified

Targets

Details1. Muscarinic acetylcholine receptor M1

Kind: Protein
Organism: Human
Pharmacological action: Yes
Actions: Antagonist

General Function: Phosphatidylinositol phospholipase c activity
Specific Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the...
Gene Name: CHRM1
Uniprot ID: P11229
Uniprot Name: Muscarinic acetylcholine receptor M1
Molecular Weight: 51420.375 Da

References

Wellington K: Ipratropium bromide HFA. Treat Respir Med. 2005;4(3):215-20; discussion 221-2. [PubMed:15987237]

Details2. Muscarinic acetylcholine receptor M2

Kind: Protein
Organism: Human
Pharmacological action: Yes
Actions: Antagonist

General Function: G-protein coupled acetylcholine receptor activity
Specific Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the...
Gene Name: CHRM2
Uniprot ID: P08172
Uniprot Name: Muscarinic acetylcholine receptor M2
Molecular Weight: 51714.605 Da

References

Wellington K: Ipratropium bromide HFA. Treat Respir Med. 2005;4(3):215-20; discussion 221-2. [PubMed:15987237]

Details3. Muscarinic acetylcholine receptor M3

Kind: Protein
Organism: Human
Pharmacological action: Yes
Actions: Antagonist

General Function: Receptor activity
Specific Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the...
Gene Name: CHRM3
Uniprot ID: P20309
Uniprot Name: Muscarinic acetylcholine receptor M3
Molecular Weight: 66127.445 Da

References

Wellington K: Ipratropium bromide HFA. Treat Respir Med. 2005;4(3):215-20; discussion 221-2. [PubMed:15987237]

Enzymes

Details1. Cytochrome P450 2D6

Kind: Protein
Organism: Human
Pharmacological action: Unknown
Actions: Substrate

General Function: Steroid hydroxylase activity
Specific Function: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name: CYP2D6
Uniprot ID: P10635
Uniprot Name: Cytochrome P450 2D6
Molecular Weight: 55768.94 Da

References

Keam SJ, Keating GM: Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD. Treat Respir Med. 2004;3(4):247-68. [PubMed:15350163]

Details2. Cytochrome P450 3A4

Kind: Protein
Organism: Human
Pharmacological action: Unknown
Actions: Substrate

General Function: Vitamin d3 25-hydroxylase activity
Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name: CYP3A4
Uniprot ID: P08684
Uniprot Name: Cytochrome P450 3A4
Molecular Weight: 57342.67 Da

References

Keam SJ, Keating GM: Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD. Treat Respir Med. 2004;3(4):247-68. [PubMed:15350163]

Transporters

Details1. Solute carrier family 22 member 5

Kind: Protein
Organism: Human
Pharmacological action: Unknown
Actions: Substrate

General Function: Symporter activity
Specific Function: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cat...
Gene Name: SLC22A5
Uniprot ID: O76082
Uniprot Name: Solute carrier family 22 member 5
Molecular Weight: 62751.08 Da

References

Nakamura T, Nakanishi T, Haruta T, Shirasaka Y, Keogh JP, Tamai I: Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95. doi: 10.1021/mp900206j. [PubMed:20020740]

Details2. Solute carrier family 22 member 4

Kind: Protein
Organism: Human
Pharmacological action: Unknown
Actions: Substrate

General Function: Symporter activity
Specific Function: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without...
Gene Name: SLC22A4
Uniprot ID: Q9H015
Uniprot Name: Solute carrier family 22 member 4
Molecular Weight: 62154.48 Da

References

Nakamura T, Nakanishi T, Haruta T, Shirasaka Y, Keogh JP, Tamai I: Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95. doi: 10.1021/mp900206j. [PubMed:20020740]

Drug created on June 13, 2005 07:24 / Updated on July 13, 2018 01:17

Ipratropium

Identification

Structure for DB00332 (Ipratropium)

Pharmacology

Interactions

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Taxonomy

Targets

References

References

References

Enzymes

References

References

Transporters

References

References