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Displaying drugs 101 - 125 of 621 in total

Ofatumumab

Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however, the antigen is...
Approved
Matched Description: … [L12612] Although it has a similar molecular mechanism of action as [rituximab], another CD-20 monoclonal ... In Phase III clinical trials consisting of subjects with relapsing forms of multiple sclerosis (RMS), ... subcutaneous administration of ofatumumab reduced the number of relapses and delayed disease progression …
Matched Categories: … CD20 (Clusters of Differentiation 20) inhibitors …

Gliclazide

Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It has been classified differently according to its drug properties in which based on its chemical structure, gliclazide is considered a first-generation sulfonylurea due to the structural presence of a sulfonamide group able to release...
Approved
Matched Description: … Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake ... Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination ... the last 8-10 weeks of glucose control). …
Matched Categories: … combinations of sulfonamides …

Carisoprodol

Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications . This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with...
Approved
Matched Description: … Schedule IV substance under the controlled substances act in several US states due to alarming rates of ... abuse [A176062, A176077] despite having a low potential for abuse in addition to a low risk of dependence …

Dextrothyroxine

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum...
Approved
Investigational
Matched Description: … Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines ... Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory …

Rofecoxib

Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 )...
Approved
Investigational
Withdrawn
Matched Description: … doses of 125, 25, and 50 mg is approximately 93%. ... The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids. ... primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. …

Tenofovir alafenamide

Tenofovir alafenamide is a novel tenofovir prodrug developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal...
Approved
Matched Description: … [A178060] Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Zuranolone

Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAA receptors. Unlike other more common GABAA positive allosteric modulators on the market like benzodiazepines, zuranolone can modulate both synaptic and extrasynaptic GABAA conductance due to binding to a non-benzodiazepine site on the receptor.[A260776,A260786] Zuranolone was...
Approved
Experimental
Matched Description: … Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAAof an oral, once-daily dosing formulation. ... [A260776,A260786] Zuranolone was designed with a pharmacological profile of a neuroactive steroid in …

Pravastatin

Pravastatin is the 6-alpha-hydroxy acid form of mevastatin. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved...
Approved
Matched Description: … Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. ... The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation …

Phenytoin

Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. …
Matched Categories: … Inducers of Drug Clearance ... Metabolic Side Effects of Drugs and Substances …

Fluorouracil

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Approved
Matched Description: … It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid …

Fingolimod

Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially approved by the FDA in 2010. Fingolimod was also...
Approved
Investigational
Matched Description: … [L12651] Fingolimod was also studied for the treatment of COVID-19, the disease caused by infection with ... [A176474] Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting …

Monobenzone

Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. It may also cause...
Approved
Matched Description: … It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes ... It may also cause destruction of melanocytes and permanent depigmentation. ... Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. …

Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and...
Approved
Matched Description: … non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of ... [A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development ... the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of …
Matched Mixtures name: … Dual Action ... Dual Action ... Dual Action …

Sildenafil

In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to...
Approved
Investigational
Matched Description: … In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic ... Nevertheless, it is because of this mechanism that sildenafil is also indicated for treating pulmonary ... Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a …
Matched Categories: … combinations of sulfonamides …

Venlafaxine

Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, desvenlafaxine, works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and...
Approved
Matched Description: … for the management of neuropathic pain (although there is only minimal evidence of efficacy for this ... Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine ... [L43030] The immediate formulation of the drug, marketed as Effexor, was first approved by the FDA in …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Iodoform

Iodoform is an organoiodine compound with the formula CHI3 and a tetrahedral molecular geometry. It is a relatively water-insoluble yellow solid that is chemically reactive in free-radical reactions . Due to its antimicrobial properties following topical administration, minimal levels of iodoform may be found in disinfectants and it is more...
Approved
Experimental
Vet approved
Matched Description: … Due to its antimicrobial properties following topical administration, minimal levels of iodoform may ... Since the beginning of the 20th century, iodoform has been commonly used as a healing and antiseptic ... Iodoform is soluble in fatty acids and decomposes releasing iodine in nascent state (96,7% of iodine) …

Lorlatinib

Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive...
Approved
Investigational
Matched Description: … It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously ... ALK-positive metastatic non-small cell lung cancer[L39905] which was first approved by the US FDA in November of …

Sirolimus

Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor...
Approved
Investigational
Matched Description: … [A13448] Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR ... the Vai Atari region of Rapa Nui (Easter Island). ... lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of …
Matched Categories: … Mammalian target of rapamycin (mTOR) kinase inhibitors …

Enflurane

Enflurane is a halogenated inhalational anesthetic initially approved by the FDA in 1972. Since this date, it has been withdrawn from the US market.[L13646,L13649] Unlike its other inhalational anesthetic counterparts including isoflurane and halothane, enflurane is known to induce seizure activity. In addition, it is known to cause increased cardio...
Approved
Investigational
Vet approved

Ganaxolone

Ganaxolone is the 3β-methylated synthetic analog of allopregnanolone, a metabolite of progesterone. Ganaxolone belongs to a class of compounds referred to as neurosteroids. Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone, bind potently and specifically to GABAA receptors to enhance their inhibitory effects, and are thus known to...
Approved
Investigational
Matched Description: … Ganaxolone is the 3β-methylated synthetic analog of [allopregnanolone],[L41130] a metabolite of [progesterone ... [A3197] Ganaxolone belongs to a class of compounds referred to as neurosteroids. ... [L41130] It was approved under the brand name ZTALMY by the US FDA in March 2022 for the treatment of …

Apremilast

Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as Roflumilast and Crisaborole.[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July 2019, apremilast was granted...
Approved
Investigational
Matched Description: … Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of ... [L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated …

Sodium oxybate

Sodium oxybate (Xyrem) is a central nervous system (CNS) depressant used to treat cataplexy or excessive daytime sleepiness associated with narcolepsy. It is a sodium salt of gamma-Hydroxybutyric acid, an endogenous cerebral inhibitory neurotransmitter and a metabolite of the inhibitory neurotransmitter GABA. Due to its physiological effects, sodium oxybate is...
Approved
Matched Description: … [A251445] and a metabolite of the inhibitory neurotransmitter GABA. ... [L30598] An extended-release oral suspension formulation of sodium oxybate for narcolepsy, marketed ... [L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmitter …

Baclofen

Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and...
Approved
Matched Description: … [A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins …

Lacosamide

Lacosamide is an antiepileptic drug used to treat seizures. As a chiral functionalized amino acid, it works by blocking slowly inactivating components of voltage-gated sodium currents. Lacosamide exhibits a stereoselective mode of interaction with sodium channels. Lacosamide was first approved by the European Commission in August 2008 and was later...
Approved
Matched Description: … Lacosamide exhibits a stereoselective mode of interaction with sodium channels. ... As a chiral functionalized amino acid, it works by blocking slowly inactivating components of voltage-gated …

Brexpiprazole

Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to aripiprazole, brexpiprazole has different binding affinities for dopamine and serotonin receptors. Compared...
Approved
Investigational
Matched Description: … [A182186] Currently approved for the treatment of depression, schizophrenia, and agitation associated …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Displaying drugs 101 - 125 of 621 in total