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Identification
NameMeclizine
Accession NumberDB00737  (APRD00354)
TypeSmall Molecule
GroupsApproved
DescriptionA histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem]
Structure
Thumb
Synonyms
Meclizine
Meclozine
Nevidoxine
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Antiverttablet12.5 mg/1oralRoerig1997-04-11Not applicableUs
Antiverttablet25 mg/1oralRoerig1997-04-11Not applicableUs
Antiverttablet50 mg/1oralRoerig1997-04-11Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Meclizine Hydrochloridetablet25 mg/1oralBlenheim Pharmacal, Inc.2012-08-01Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralPar Pharmaceutical, Inc.1981-06-03Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-05-24Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2010-06-04Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralAmerican Health Packaging2011-07-01Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralMylan Pharmaceuticals Inc.2012-09-19Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-06-04Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralUnit Dose Services2010-06-04Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralPhysicians Total Care, Inc.1994-07-05Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralDIRECT RX2014-01-01Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-04-30Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralRebel Distributors Corp.1981-06-03Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2010-02-12Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralA S Medication Solutions Llc2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralSt Marys Medical Park Pharmacy.2014-05-22Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralAv Kare, Inc.2012-05-042015-12-29Us
Meclizine Hydrochloridetablet25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1981-06-03Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralEpic Pharma, LLC2012-04-30Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralMylan Institutional Inc.2014-12-08Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralCardinal Health2011-05-13Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralAmneal Pharmaceuticals, LLC2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralBlenheim Pharmacal, Inc.2009-12-16Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-01-23Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralH.J. Harkins Company, Inc.2010-06-04Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2010-06-04Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralAmerican Health Packaging2011-07-01Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralMylan Pharmaceuticals Inc.2012-09-19Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-06-04Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralUDL Laboratories, Inc.2011-05-13Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralCardinal Health2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralDIRECT RX2015-01-01Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralUnit Dose Services1981-06-03Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralRebel Distributors Corp.1981-06-03Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2014-11-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralCardinal Health1981-06-032015-12-29Us
Meclizine Hydrochloridetablet12.5 mg/1oralMajor Pharmaceuticals2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.1981-06-03Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralNorthwind Pharmaceuticals, LLC2014-07-24Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralCardinal Health2011-05-13Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralAmneal Pharmaceuticals, LLC2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralSTAT Rx USA LLC1981-06-03Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralA S Medication Solutions Llc1981-06-03Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralH.J. Harkins Company, Inc.1981-06-03Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralGolden State Medical Supply, Inc.1998-10-05Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralLife Line Home Care Services, Inc.2010-06-04Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralLiberty Pharmaceuticals, Inc.1981-06-03Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralAv Kare, Inc.2012-05-04Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralUDL Laboratories, Inc.2011-05-13Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralCardinal Health2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralProficient Rx LP2012-04-30Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-10-08Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralAv Pak2013-08-08Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2015-01-26Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralAvera Mc Kennan Hospital2015-08-07Not applicableUs
Meclizine Hydrochloridetablet50 mg/1oralAmneal Pharmaceuticals, LLC2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralMajor Pharmaceuticals2010-02-12Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralPar Pharmaceutical, Inc.1981-06-03Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralNorthwind Pharmaceuticals, LLC2015-02-26Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralClinical Solutions Wholesale2010-06-04Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralSTAT Rx USA LLC1981-06-03Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralA S Medication Solutions Llc2010-02-12Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralGolden State Medical Supply, Inc.1981-06-03Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralMc Kesson Contract Packaging2012-01-03Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1981-06-03Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralEpic Pharma, LLC2012-04-30Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralMylan Institutional Inc.2014-10-13Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralCardinal Health2014-10-13Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralbryant ranch prepack1981-06-03Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2015-05-26Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.2012-09-19Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralAidarex Pharmaceuticals LLC2010-06-04Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralAv Pak2013-08-08Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralPhysicians Total Care, Inc.1992-08-13Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Bonaminetablet (immediate release)25 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Bonamine Tab 25mg Chewabletablet (chewable)25 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1954-12-312011-08-04Canada
Boninetablet, chewable25 mg/1oralWell Spring Pharmaceutical Corporation2014-12-15Not applicableUs
Boninetablet, chewable25 mg/1oralInsight Pharmaceuticals2009-06-08Not applicableUs
Cvs Motion Sickness Fast Meltingtablet, orally disintegrating25 mg/1oralCVS Pharmacy, Inc.2015-08-27Not applicableUs
Dramamine Less Drowsytablet25 mg/1oralMedtech Products Inc.2011-09-01Not applicableUs
Less Drowsy Formula Motion Sickness Relieftablet25 mg/1oralSalado Sales, Inc.2002-06-24Not applicableUs
Less Drowsy Motion Sickness Relieftablet25 mg/1oralWal Mart Stores Inc2002-06-24Not applicableUs
Less Drowsy Motion Sickness Relieftablet25 mg/1oralFamily Dollar2002-06-24Not applicableUs
Less Drowsy Motion Sickness Relieftablet25 mg/1oralRite Aid2002-06-24Not applicableUs
Less Drowsy Motion Sickness Relieftablet25 mg/1oralDiscount Drug Mart2014-12-01Not applicableUs
Meclizinetablet25 mg/1oralContract Pharmacal Corp2001-07-24Not applicableUs
Meclizinetablet25 mg/1oralContract Pharmacal Corp2001-07-24Not applicableUs
Meclizine HCltablet25 mg/1oralAidarex Pharmaceuticals LLC2008-07-22Not applicableUs
Meclizine HCltablet12.5 mg/1oralPreferred Pharmaceuticals, Inc.2012-12-13Not applicableUs
Meclizine HCltablet12.5 mg/1oralTrigen Laboratories, Inc.2013-09-23Not applicableUs
Meclizine HCltablet12.5 mg/1oralbryant ranch prepack2006-07-14Not applicableUs
Meclizine HCltablet12.5 mg/1oralRugby Laboratories Inc.2006-07-14Not applicableUs
Meclizine HCltablet12.5 mg/1oralAidarex Pharmaceuticals LLC2006-07-14Not applicableUs
Meclizine HCltablet25 mg/1oralTrigen Laboratories, Inc.2013-09-23Not applicableUs
Meclizine HCltablet25 mg/1oralbryant ranch prepack2008-07-22Not applicableUs
Meclizine HCltablet25 mg/1oralREMEDYREPACK INC.2015-03-27Not applicableUs
Meclizine HCltablet25 mg/1oralRugby Laboratories Inc.2008-07-22Not applicableUs
Meclizine HCltablet, chewable25 mg/1oralTrigen Laboratories, Inc.2013-09-23Not applicableUs
Meclizine HCltablet25 mg/1oralPreferred Pharmaceuticals, Inc.2012-12-13Not applicableUs
Meclizine HCltablet12.5 mg/1oralBlenheim Pharmacal, Inc.2010-06-11Not applicableUs
Meclizine HCl 25 mgtablet, chewable25 mg/1oralGemini Pharmaceuticals, Inc. dba Plus Pharma2015-10-15Not applicableUs
Meclizine Hydrochloridetablet25 mg/1oralSandoz Inc1989-05-22Not applicableUs
Meclizine Hydrochloridetablet12.5 mg/1oralSandoz Inc1989-05-22Not applicableUs
Medique Medi-meclizinetablet, film coated25 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs
Medique Medi-meclizinetablet25 mg/1oralUnifirst First Aid Corporation2013-09-01Not applicableUs
Motion Relief - Less Drowsy Formulatablet25 mg/1oralMc Kesson (Health Mart)2012-06-26Not applicableUs
Motion Sicknesstablet25 mg/1oralArmy and Air Force Exchange Service2002-06-24Not applicableUs
Motion Sicknesstablet25 mg/1oralThe Kroger Co.2010-07-11Not applicableUs
Motion Sicknesstablet25 mg/1oralHy Vee2014-03-28Not applicableUs
Motion Sickness IItablet25 mg/1oralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.2002-06-24Not applicableUs
Motion Sickness IItablet25 mg/1oralHealthy Accents (DZA Brands, LLC)2013-12-30Not applicableUs
Motion Sickness IItablet25 mg/1oralCVS Pharmacy2013-12-30Not applicableUs
Motion Sickness IItablet25 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2002-06-24Not applicableUs
Motion Sickness IItablet25 mg/1oralTOP CARE (Topco Associates LLC)2013-05-31Not applicableUs
Motion Sickness Less Drowsy Formulatablet25 mg/1oralGood Sense (Geiss, Destin & Dunn, Inc.)2012-03-19Not applicableUs
Motion Sickness Less Drowsy Formulatablet25 mg/1oralMEIJER, INC.2014-03-28Not applicableUs
Motion Sickness Less Drowsy Formulatablet25 mg/1oralMc Kesson (Sunmark)2010-07-09Not applicableUs
Motion Sickness Relieftablet, chewable25 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2002-05-29Not applicableUs
Motion Sickness Relieftablet25 mg/1oralTarget Corporation2002-06-24Not applicableUs
Motion Sickness Relieftablet25 mg/1oralSUPERVALU INC.2002-06-24Not applicableUs
Motion Sickness Relieftablet, chewable25 mg/1oralWALGREEN CO.2002-05-29Not applicableUs
Motion Sickness Relieftablet, chewable25 mg/1oralRite Aid2002-05-29Not applicableUs
Motion Sickness Relieftablet, chewable25 mg/1oralSUPERVALU INC.2002-05-29Not applicableUs
Motion Sickness Relieftablet25 mg/1oralAmerisource Bergen Drug Corporation (Good Neighbor Pharmacy) 243852010-07-09Not applicableUs
Motion Sickness Relieftablet25 mg/1oralGreenbrier International, Inc.2002-06-24Not applicableUs
Motion Sickness Relieftablet25 mg/1oralNash Finch Company2002-06-24Not applicableUs
Motion Sickness Relieftablet25 mg/1oralL.N.K. International, Inc.2002-06-24Not applicableUs
Motion Sickness Relieftablet25 mg/1oralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2012-10-03Not applicableUs
Motion Sickness Relief Less Drowsytablet25 mg/1oralSMART SENSE (Kmart)2014-02-28Not applicableUs
Motion Sickness Relief Less Drowsytablet25 mg/1oralBetter Living Brands, Llc2002-06-24Not applicableUs
Motion-time Chewabletablet, chewable25 mg/251oralTime Cap Labs, Inc2010-08-09Not applicableUs
Naus-easefilm, soluble25 mg/1oralSunascen Therapeutics Llc2012-04-16Not applicableUs
Naus-easetablet25 mg/1oralSunascen Therapeutics Llc2012-04-16Not applicableUs
Rugby Meclizine HCl, 12.5 Mg Each Antiemetictablet12.5 mg/1oralRugby Laboratories2014-03-07Not applicableUs
Rugby Travel Sickness Meclizine HCl, 25 Mg Each (antiemetic)tablet, chewable25 mg/1oralProficient Rx LP2014-08-19Not applicableUs
Rugby Travel Sickness Meclizine HCl, 25 Mg Each (antiemetic)tablet, chewable25 mg/1oralRugby Laboratories2014-08-19Not applicableUs
Rugby Travel Sickness Meclizine HCl, 25 Mg Each (antiemetic)tablet, chewable25 mg/1oralApotheca Inc.2014-08-19Not applicableUs
Rugby Travel Sicknessmeclizine HCl, 25 Mg Each (antiemetic) Meclizine HCl, 25 Mg Each (antiemetic)tablet, chewable25 mg/1oralREMEDYREPACK INC.2015-04-02Not applicableUs
Rugbymeclizine HCl, 12.5 Mg Each Antiemetic Meclizine HCl, 12.5 Mg Each Antiemetictablet12.5 mg/1oralREMEDYREPACK INC.2015-04-02Not applicableUs
Sea-calmtablet, chewable25 mg/1oralBellegrove2009-03-16Not applicableUs
Trav-L-tabstablet25 mg/1oralBell Pharmaceuticals, Inc.2014-12-01Not applicableUs
Travel Easetablet, chewable25 mg/1oralChain Drug Marketing Association Inc2002-05-29Not applicableUs
Travel Timetablet, chewable25 mg/1oralProvision Medical Products2015-04-03Not applicableUs
Travel-easetablet25 mg/1oralGeri Care Pharmaceutical Corp2004-01-01Not applicableUs
Verticalmtablet25 mg/1oralAlva Amco Pharmacal Companies, Inc.2012-04-16Not applicableUs
Wal Dramtablet25 mg/1oralWALGREEN CO.2002-06-24Not applicableUs
Zentripfilm, soluble25 mg/1oralSato Pharmaceutical Co., Ltd.2009-02-03Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
ChiclidaNot Available
MeclicotNot Available
NavicalmNot Available
PostafenNot Available
Sea-LegsNot Available
Brand mixtures
NameLabellerIngredients
Antivert TabPfizer Canada Inc
Salts
Name/CASStructureProperties
Meclizine Hydrochloride
Thumb
  • InChI Key: BAAVORPTHSKWGJ-UHFFFAOYNA-N
  • Monoisotopic Mass: 444.173519006
  • Average Mass: 445.424
DBSALT000678
Categories
UNII3L5TQ84570
CAS number569-65-3
WeightAverage: 390.948
Monoisotopic: 390.186276581
Chemical FormulaC25H27ClN2
InChI KeyInChIKey=OCJYIGYOJCODJL-UHFFFAOYSA-N
InChI
InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3
IUPAC Name
1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
SMILES
CC1=CC(CN2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Phenylmethylamine
  • Benzylamine
  • Aralkylamine
  • N-alkylpiperazine
  • Toluene
  • Halobenzene
  • Chlorobenzene
  • Piperazine
  • 1,4-diazinane
  • Aryl halide
  • Aryl chloride
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
PharmacodynamicsMeclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Mechanism of actionAlong with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.
Related Articles
AbsorptionWell absorbed
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic

Route of eliminationNot Available
Half life6 hours
ClearanceNot Available
ToxicitySymptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9318
Blood Brain Barrier+0.9656
Caco-2 permeable+0.6369
P-glycoprotein substrateSubstrate0.7422
P-glycoprotein inhibitor IInhibitor0.8149
P-glycoprotein inhibitor IINon-inhibitor0.8042
Renal organic cation transporterInhibitor0.7859
CYP450 2C9 substrateNon-substrate0.8416
CYP450 2D6 substrateNon-substrate0.5134
CYP450 3A4 substrateNon-substrate0.6059
CYP450 1A2 substrateInhibitor0.806
CYP450 2C9 inhibitorNon-inhibitor0.9698
CYP450 2D6 inhibitorInhibitor0.9521
CYP450 2C19 inhibitorInhibitor0.5209
CYP450 3A4 inhibitorNon-inhibitor0.8896
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.7063
Ames testNon AMES toxic0.8536
CarcinogenicityNon-carcinogens0.9343
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.3803 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.6113
hERG inhibition (predictor II)Inhibitor0.8104
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
Packagers
Dosage forms
FormRouteStrength
Tabletoral12.5 mg/1
Tabletoral25 mg/1
Tabletoral50 mg/1
Tabletoral
Tablet (immediate release)oral25 mg
Tablet (chewable)oral25 mg
Tablet, orally disintegratingoral25 mg/1
Tablet, film coatedoral25 mg/1
Tablet, chewableoral25 mg/1
Tablet, chewableoral25 mg/251
Film, solubleoral25 mg/1
Prices
Unit descriptionCostUnit
Meclizine HCl 100 25 mg tablet Box89.97USD box
Antivert 50 mg tablet2.12USD tablet
Antivert 25 mg tablet1.23USD tablet
Meclizine hcl powder1.04USD g
Vertin-32 tablet0.9USD tablet
Antivert 12.5 mg tablet0.82USD tablet
Meclizine HCl 25 mg tablet0.67USD tablet
Meclizine 12.5 mg tablet0.62USD tablet
Sm motion sicknes 25 mg tablet0.5USD tablet
Meclizine HCl 12.5 mg tablet0.43USD tablet
Dramamine less drowsy tablet0.42USD tablet
Bonamine 25 mg Chewable Tablet0.33USD tablet
Dramamine 50 mg tablet0.28USD tablet
Meclizine 25 mg tablet0.07USD tablet
Medi-meclizine 25 mg tablet0.06USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point217-224U.S. Patent 2,709,169.
water solubility0.1gm/100mlNot Available
logP5.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00103 mg/mLALOGPS
logP5.59ALOGPS
logP6.39ChemAxon
logS-5.6ALOGPS
pKa (Strongest Basic)8.16ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area6.48 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity119.39 m3·mol-1ChemAxon
Polarizability44.87 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0ap0-1910000000-a39cf62803f22b3df281View in MoNA
References
Synthesis Reference

U.S. Patent 2,709,169.

General ReferencesNot Available
External Links
ATC CodesR06AE55R06AE05
AHFS Codes
  • 56:22.08
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Meclizine.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Meclizine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Meclizine.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Meclizine.
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Meclizine.
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Meclizine.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Meclizine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Meclizine.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Meclizine.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Meclizine.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Meclizine.
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Meclizine.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Meclizine.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Meclizine.
AmoxapineThe risk or severity of adverse effects can be increased when Meclizine is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Meclizine.
AmphetamineAmphetamine may decrease the sedative activities of Meclizine.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Meclizine.
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Meclizine.
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Meclizine.
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Meclizine.
AzelastineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Meclizine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Meclizine.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Meclizine.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Meclizine.
BenzphetamineBenzphetamine may decrease the sedative activities of Meclizine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Meclizine.
Benzylpenicilloyl PolylysineMeclizine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Meclizine.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Meclizine is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
BrimonidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Meclizine.
BrompheniramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Meclizine.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Meclizine.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Meclizine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Meclizine.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Meclizine.
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Meclizine.
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Meclizine.
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Meclizine.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Meclizine.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Meclizine.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Meclizine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Meclizine.
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Meclizine.
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Meclizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Meclizine.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Meclizine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Meclizine.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Meclizine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Chlorphenamine.
ChlorphentermineChlorphentermine may decrease the sedative activities of Meclizine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Meclizine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Meclizine.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Meclizine.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Meclizine.
CitalopramThe risk or severity of adverse effects can be increased when Meclizine is combined with Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Meclizine.
ClidiniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Meclizine.
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Meclizine.
ClomipramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Meclizine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Meclizine.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Meclizine.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Meclizine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Meclizine.
CyclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Meclizine.
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Meclizine.
DantroleneThe risk or severity of adverse effects can be increased when Meclizine is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Meclizine.
DapoxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dapoxetine.
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Meclizine.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Meclizine.
DesipramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Meclizine is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Meclizine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Meclizine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Meclizine.
DextroamphetamineDextroamphetamine may decrease the sedative activities of Meclizine.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Meclizine.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Meclizine.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Meclizine.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Meclizine.
DifenoxinThe risk or severity of adverse effects can be increased when Meclizine is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Meclizine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Meclizine.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Meclizine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Meclizine is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Meclizine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Meclizine.
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Meclizine.
DoxepinThe risk or severity of adverse effects can be increased when Meclizine is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
DoxylamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Meclizine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Meclizine.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Meclizine.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Meclizine.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Meclizine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Meclizine.
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Meclizine.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Meclizine.
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Meclizine.
EscitalopramThe risk or severity of adverse effects can be increased when Meclizine is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Meclizine.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Meclizine.
EthanolMeclizine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Meclizine.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Meclizine.
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Meclizine.
EthotoinThe risk or severity of adverse effects can be increased when Meclizine is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Meclizine.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Meclizine.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Meclizine.
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Meclizine.
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Meclizine.
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Meclizine.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Meclizine.
EtoperidoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Meclizine.
EzogabineThe risk or severity of adverse effects can be increased when Meclizine is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Meclizine is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Meclizine.
FenfluramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Meclizine.
FexofenadineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Meclizine.
FlunarizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Meclizine.
FluoxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Meclizine.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Meclizine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Meclizine.
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Meclizine.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Meclizine.
FluvoxamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fluvoxamine.
FosphenytoinThe risk or severity of adverse effects can be increased when Meclizine is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Meclizine.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Meclizine.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Meclizine is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Meclizine.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Meclizine.
GuanfacineThe risk or severity of adverse effects can be increased when Meclizine is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Meclizine.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Meclizine.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Meclizine.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Meclizine.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Meclizine.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Meclizine.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Meclizine.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Meclizine.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Meclizine.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
HydroxyzineThe risk or severity of adverse effects can be increased when Meclizine is combined with Hydroxyzine.
IloperidoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Meclizine.
IndalpineThe risk or severity of adverse effects can be increased when Meclizine is combined with Indalpine.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Meclizine.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Meclizine.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Meclizine.
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Meclizine.
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Meclizine.
LevetiracetamThe risk or severity of adverse effects can be increased when Meclizine is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Meclizine.
LevocabastineThe risk or severity of adverse effects can be increased when Meclizine is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Meclizine is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Meclizine.
LevomilnacipranThe risk or severity of adverse effects can be increased when Meclizine is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Meclizine.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Meclizine.
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Meclizine.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Meclizine.
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Meclizine.
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Meclizine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Meclizine.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Meclizine.
Lu AA21004The risk or severity of adverse effects can be increased when Meclizine is combined with Lu AA21004.
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Meclizine.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Meclizine is combined with Maprotiline.
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Meclizine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Meclizine.
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Meclizine.
MephentermineMephentermine may decrease the sedative activities of Meclizine.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Meclizine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Meclizine.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Meclizine.
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Meclizine.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Meclizine.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Meclizine.
MethamphetamineMethamphetamine may decrease the sedative activities of Meclizine.
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Meclizine.
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Meclizine.
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Meclizine.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Meclizine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Meclizine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Meclizine.
MethsuximideThe risk or severity of adverse effects can be increased when Meclizine is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Meclizine.
MetyrosineMeclizine may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Meclizine.
MilnacipranThe risk or severity of adverse effects can be increased when Meclizine is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
MirtazapineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Meclizine.
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Meclizine.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Meclizine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
NabiloneThe risk or severity of adverse effects can be increased when Meclizine is combined with Nabilone.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Meclizine.
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Meclizine.
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Meclizine.
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Meclizine.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Meclizine.
OlanzapineThe risk or severity of adverse effects can be increased when Meclizine is combined with Olanzapine.
OlopatadineThe risk or severity of adverse effects can be increased when Meclizine is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Meclizine.
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Meclizine.
OrphenadrineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Meclizine.
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Meclizine.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Meclizine.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Meclizine.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Meclizine.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Meclizine.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Meclizine.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Meclizine.
ParaldehydeMeclizine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Meclizine.
ParoxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Paroxetine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Meclizine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Meclizine.
PerampanelThe risk or severity of adverse effects can be increased when Meclizine is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Meclizine.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Meclizine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Meclizine.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Meclizine.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Meclizine.
PhenterminePhentermine may decrease the sedative activities of Meclizine.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Meclizine.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Meclizine.
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Meclizine.
PipotiazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Meclizine is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Meclizine is combined with Pomalidomide.
PramipexoleMeclizine may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Meclizine.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Meclizine.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Meclizine.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Meclizine.
PrimidoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Meclizine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Meclizine.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Meclizine.
PromethazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Meclizine.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Meclizine.
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Meclizine.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Meclizine.
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Meclizine.
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Meclizine.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Meclizine.
RamelteonThe risk or severity of adverse effects can be increased when Meclizine is combined with Ramelteon.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Meclizine.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Meclizine.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Meclizine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Meclizine.
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Meclizine.
RopiniroleMeclizine may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Meclizine.
RotigotineMeclizine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Meclizine.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Meclizine.
ScopolamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Meclizine.
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Meclizine.
SertralineThe risk or severity of adverse effects can be increased when Meclizine is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Meclizine.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Meclizine.
StiripentolThe risk or severity of adverse effects can be increased when Meclizine is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Meclizine.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Meclizine.
SuvorexantThe risk or severity of adverse effects can be increased when Meclizine is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Meclizine is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Meclizine is combined with Tasimelteon.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Meclizine.
TetrabenazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Meclizine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Meclizine.
ThalidomideMeclizine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Meclizine.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Meclizine.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Meclizine.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Meclizine.
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Meclizine.
TiagabineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tiagabine.
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Meclizine.
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Meclizine.
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Meclizine.
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Meclizine.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Meclizine.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Meclizine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Meclizine.
TrazodoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Meclizine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Meclizine.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Meclizine.
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Meclizine.
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Meclizine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Meclizine.
VigabatrinThe risk or severity of adverse effects can be increased when Meclizine is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Vilazodone.
VortioxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Meclizine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Meclizine.
ZiconotideThe risk or severity of adverse effects can be increased when Meclizine is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Meclizine.
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Meclizine.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Meclizine.
ZonisamideThe risk or severity of adverse effects can be increased when Meclizine is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Meclizine.
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Meclizine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Meclizine.
Food Interactions
  • Take with food to reduce irritation. Avoid alcohol.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Oishi R, Shishido S, Yamori M, Saeki K: Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb;349(2):140-4. [PubMed:7513381 ]
  2. Martins MA, Pasquale CP, e Silva PM, Pires AL, Ruffie C, Rihoux JP, Cordeiro RS, Vargaftig BB: Interference of cetirizine with the late eosinophil accumulation induced by either PAF or compound 48/80. Br J Pharmacol. 1992 Jan;105(1):176-80. [PubMed:1350745 ]
  3. Pasquale CP, e Silva PM, Lima MC, Diaz BL, Rihoux JP, Vargaftig BB, Cordeiro RS, Martins MA: Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized rats. Eur J Pharmacol. 1992 Nov 13;223(1):9-14. [PubMed:1362160 ]
  4. Taniguchi K, Masuda Y, Takanaka K: Inhibitory effects of histamine H1 receptor blocking drugs on metabolic activations of neutrophils. J Pharmacobiodyn. 1991 Feb;14(2):87-93. [PubMed:1678430 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23