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Identification
NameMeclizine
Accession NumberDB00737  (APRD00354)
TypeSmall Molecule
GroupsApproved
Description

A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem]

Structure
Thumb
Synonyms
Meclizine
Meclozine
Nevidoxine
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Antiverttablet12.5 mg/1oralRoerig1997-04-112016-04-23Us
Antiverttablet50 mg/1oralRoerig1997-04-112016-04-23Us
Antiverttablet25 mg/1oralRoerig1997-04-112016-04-23Us
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Meclizine Hydrochloridetablet25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-04-302016-04-23Us
Meclizine Hydrochloridetablet12.5 mg/1oralAmerican Health Packaging2011-07-012016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralCardinal Health2011-05-132016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralA S Medication Solutions Llc2010-02-122016-04-05Us
Meclizine Hydrochloridetablet50 mg/1oralAmneal Pharmaceuticals, LLC2010-02-122016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralMylan Institutional Inc.2014-10-132016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2015-01-262016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-06-042016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralCardinal Health2011-05-132016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralBlenheim Pharmacal, Inc.2009-12-162016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralMylan Pharmaceuticals Inc.2012-09-192016-04-23Us
Meclizine Hydrochloridetablet25 mg/1oralUDL Laboratories, Inc.2011-05-132016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralA S Medication Solutions Llc2010-02-122016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralAv Kare, Inc.2012-05-042016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralCardinal Health2014-10-132016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralAmneal Pharmaceuticals, LLC2010-02-122016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2014-11-122016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-06-042016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralBlenheim Pharmacal, Inc.2012-08-012016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralUDL Laboratories, Inc.2011-05-132016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralA S Medication Solutions Llc1981-06-032016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.2012-09-192016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralCardinal Health2010-02-122016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralH.J. Harkins Company, Inc.1981-06-032016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralAmneal Pharmaceuticals, LLC2010-02-122016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralSt Marys Medical Park Pharmacy.2014-05-222016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralAidarex Pharmaceuticals LLC2010-06-042016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralMajor Pharmaceuticals2010-02-122016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralUnit Dose Services1981-06-032016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-01-232016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralAvera Mc Kennan Hospital2015-08-072016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralCardinal Health2010-02-122016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralH.J. Harkins Company, Inc.2010-06-042016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralbryant ranch prepack1981-06-032016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralGolden State Medical Supply, Inc.1981-06-032016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-10-082016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralMajor Pharmaceuticals2010-02-122016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralUnit Dose Services2010-06-042016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralPar Pharmaceutical, Inc.1981-06-032016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralCardinal Health1981-06-032015-12-29Us
Meclizine Hydrochloridetablet12.5 mg/1oralPhysicians Total Care, Inc.1994-07-052016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-05-242016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralProficient Rx LP2012-04-302016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralGolden State Medical Supply, Inc.1998-10-052016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralRebel Distributors Corp.1981-06-032016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1981-06-032016-04-23Us
Meclizine Hydrochloridetablet25 mg/1oralAv Pak2013-08-082016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralPar Pharmaceutical, Inc.1981-06-032016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralAv Kare, Inc.2012-05-042015-12-29Us
Meclizine Hydrochloridetablet25 mg/1oralDIRECT RX2015-01-012016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2010-06-042016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralRebel Distributors Corp.1981-06-032016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1981-06-032016-04-23Us
Meclizine Hydrochloridetablet12.5 mg/1oralAv Pak2013-08-082016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.1981-06-032016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralMc Kesson Contract Packaging2012-01-032016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralPhysicians Total Care, Inc.1992-08-132016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralNorthwind Pharmaceuticals, LLC2015-02-262016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2010-02-122016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralEpic Pharma, LLC2012-04-302016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralLife Line Home Care Services, Inc.2010-06-042016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2010-02-122016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralNorthwind Pharmaceuticals, LLC2014-07-242016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralDIRECT RX2014-01-012016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2010-06-042016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralSTAT Rx USA LLC1981-06-032016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralLiberty Pharmaceuticals, Inc.1981-06-032016-04-23Us
Meclizine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2010-02-122016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralEpic Pharma, LLC2012-04-302016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralAmerican Health Packaging2011-07-012016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2010-02-122016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralMylan Institutional Inc.2014-12-082016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2015-05-262016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralClinical Solutions Wholesale2010-06-042016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralSTAT Rx USA LLC1981-06-032016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralMylan Pharmaceuticals Inc.2012-09-192016-04-23Us
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Bonaminetablet (immediate release)25 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Bonamine Tab 25mg Chewabletablet (chewable)25 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1954-12-312011-08-04Canada
Boninetablet, chewable25 mg/1oralWell Spring Pharmaceutical Corporation2014-12-152016-04-05Us
Boninetablet, chewable25 mg/1oralInsight Pharmaceuticals2009-06-082016-04-05Us
Cvs Motion Sickness Fast Meltingtablet, orally disintegrating25 mg/1oralCVS Pharmacy, Inc.2015-08-272016-04-05Us
Dramamine Less Drowsytablet25 mg/1oralMedtech Products Inc.2011-09-012016-04-05Us
Less Drowsy Formula Motion Sickness Relieftablet25 mg/1oralSalado Sales, Inc.2002-06-242016-04-05Us
Less Drowsy Motion Sickness Relieftablet25 mg/1oralWal Mart Stores Inc2002-06-242016-04-05Us
Less Drowsy Motion Sickness Relieftablet25 mg/1oralFamily Dollar2002-06-242016-04-05Us
Less Drowsy Motion Sickness Relieftablet25 mg/1oralRite Aid2002-06-242018-11-11Us
Less Drowsy Motion Sickness Relieftablet25 mg/1oralDiscount Drug Mart2014-12-012016-04-05Us
Meclizinetablet25 mg/1oralContract Pharmacal Corp2001-07-242016-04-05Us
Meclizinetablet25 mg/1oralContract Pharmacal Corp2001-07-242016-04-05Us
Meclizine HCltablet25 mg/1oralREMEDYREPACK INC.2015-03-272016-04-05Us
Meclizine HCltablet12.5 mg/1oralPreferred Pharmaceuticals, Inc.2012-12-132016-04-05Us
Meclizine HCltablet25 mg/1oralTrigen Laboratories, Inc.2013-09-232016-04-05Us
Meclizine HCltablet, chewable25 mg/1oralTrigen Laboratories, Inc.2013-09-232016-04-05Us
Meclizine HCltablet25 mg/1oralPreferred Pharmaceuticals, Inc.2012-12-132016-04-05Us
Meclizine HCltablet12.5 mg/1oralTrigen Laboratories, Inc.2013-09-232016-04-05Us
Meclizine HCltablet12.5 mg/1oralAidarex Pharmaceuticals LLC2006-07-142016-04-05Us
Meclizine HCltablet25 mg/1oralRugby Laboratories Inc.2008-07-222016-04-23Us
Meclizine HCltablet25 mg/1oralAidarex Pharmaceuticals LLC2008-07-222016-04-05Us
Meclizine HCltablet12.5 mg/1oralRugby Laboratories Inc.2006-07-142016-04-23Us
Meclizine HCltablet25 mg/1oralbryant ranch prepack2008-07-222016-04-05Us
Meclizine HCltablet12.5 mg/1oralBlenheim Pharmacal, Inc.2010-06-112016-04-05Us
Meclizine HCltablet12.5 mg/1oralbryant ranch prepack2006-07-142016-04-05Us
Meclizine HCl 25 mgtablet, chewable25 mg/1oralGemini Pharmaceuticals, Inc. dba Plus Pharma2015-10-152016-04-05Us
Meclizine Hydrochloridetablet25 mg/1oralSandoz Inc1989-05-222016-04-05Us
Meclizine Hydrochloridetablet12.5 mg/1oralSandoz Inc1989-05-222016-04-05Us
Medique Medi-meclizinetablet25 mg/1oralUnifirst First Aid Corporation2013-09-012016-04-05Us
Medique Medi-meclizinetablet, film coated25 mg/1oralUnifirst First Aid Corporation2008-12-302016-05-01Us
Motion Relief - Less Drowsy Formulatablet25 mg/1oralMc Kesson (Health Mart)2012-06-262016-04-05Us
Motion Sicknesstablet25 mg/1oralHy Vee2014-03-282016-04-05Us
Motion Sicknesstablet25 mg/1oralThe Kroger Co.2010-07-112016-04-05Us
Motion Sicknesstablet25 mg/1oralArmy and Air Force Exchange Service2002-06-242016-04-05Us
Motion Sickness IItablet25 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2002-06-242016-04-05Us
Motion Sickness IItablet25 mg/1oralTOP CARE (Topco Associates LLC)2013-05-312016-04-05Us
Motion Sickness IItablet25 mg/1oralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.2002-06-242016-04-05Us
Motion Sickness IItablet25 mg/1oralHealthy Accents (DZA Brands, LLC)2013-12-302016-04-05Us
Motion Sickness IItablet25 mg/1oralCVS Pharmacy2013-12-302016-04-05Us
Motion Sickness Less Drowsy Formulatablet25 mg/1oralMc Kesson (Sunmark)2010-07-092016-04-05Us
Motion Sickness Less Drowsy Formulatablet25 mg/1oralGood Sense (Geiss, Destin & Dunn, Inc.)2012-03-192016-04-05Us
Motion Sickness Less Drowsy Formulatablet25 mg/1oralMEIJER, INC.2014-03-282016-04-05Us
Motion Sickness Relieftablet25 mg/1oralGreenbrier International, Inc.2002-06-242016-04-05Us
Motion Sickness Relieftablet25 mg/1oralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2012-10-032016-04-05Us
Motion Sickness Relieftablet25 mg/1oralL.N.K. International, Inc.2002-06-242016-04-05Us
Motion Sickness Relieftablet, chewable25 mg/1oralRite Aid2002-05-292016-04-05Us
Motion Sickness Relieftablet25 mg/1oralTarget Corporation2002-06-242018-11-04Us
Motion Sickness Relieftablet25 mg/1oralAmerisource Bergen Drug Corporation (Good Neighbor Pharmacy) 243852010-07-092016-04-05Us
Motion Sickness Relieftablet, chewable25 mg/1oralSUPERVALU INC.2002-05-292016-04-05Us
Motion Sickness Relieftablet25 mg/1oralSUPERVALU INC.2002-06-242016-04-05Us
Motion Sickness Relieftablet25 mg/1oralNash Finch Company2002-06-242018-04-02Us
Motion Sickness Relieftablet, chewable25 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2002-05-292016-04-05Us
Motion Sickness Relieftablet, chewable25 mg/1oralWALGREEN CO.2002-05-292016-04-23Us
Motion Sickness Relief Less Drowsytablet25 mg/1oralSMART SENSE (Kmart)2014-02-282016-04-05Us
Motion Sickness Relief Less Drowsytablet25 mg/1oralBetter Living Brands, Llc2002-06-242016-04-05Us
Motion-time Chewabletablet, chewable25 mg/251oralTime Cap Labs, Inc2010-08-092016-04-05Us
Naus-easefilm, soluble25 mg/1oralSunascen Therapeutics Llc2012-04-162016-04-05Us
Naus-easetablet25 mg/1oralSunascen Therapeutics Llc2012-04-162016-04-05Us
Rugby Meclizine HCl, 12.5 Mg Each Antiemetictablet12.5 mg/1oralRugby Laboratories2014-03-072016-04-23Us
Rugby Travel Sickness Meclizine HCl, 25 Mg Each (antiemetic)tablet, chewable25 mg/1oralApotheca Inc.2014-08-192016-04-05Us
Rugby Travel Sickness Meclizine HCl, 25 Mg Each (antiemetic)tablet, chewable25 mg/1oralProficient Rx LP2014-08-192016-04-05Us
Rugby Travel Sickness Meclizine HCl, 25 Mg Each (antiemetic)tablet, chewable25 mg/1oralRugby Laboratories2014-08-192016-04-23Us
Rugby Travel Sicknessmeclizine HCl, 25 Mg Each (antiemetic) Meclizine HCl, 25 Mg Each (antiemetic)tablet, chewable25 mg/1oralREMEDYREPACK INC.2015-04-022016-04-05Us
Rugbymeclizine HCl, 12.5 Mg Each Antiemetic Meclizine HCl, 12.5 Mg Each Antiemetictablet12.5 mg/1oralREMEDYREPACK INC.2015-04-022016-04-05Us
Sea-calmtablet, chewable25 mg/1oralBellegrove2009-03-162016-04-05Us
Trav-L-tabstablet25 mg/1oralBell Pharmaceuticals, Inc.2014-12-012016-04-05Us
Travel Easetablet, chewable25 mg/1oralChain Drug Marketing Association Inc2002-05-292016-04-05Us
Travel Timetablet, chewable25 mg/1oralProvision Medical Products2015-04-032016-04-05Us
Travel-easetablet25 mg/1oralGeri Care Pharmaceutical Corp2004-01-012016-04-05Us
Verticalmtablet25 mg/1oralAlva Amco Pharmacal Companies, Inc.2012-04-162016-04-05Us
Wal Dramtablet25 mg/1oralWALGREEN CO.2002-06-242016-04-23Us
Zentripfilm, soluble25 mg/1oralSato Pharmaceutical Co., Ltd.2009-02-032016-04-05Us
International Brands
NameCompany
ChiclidaNot Available
MeclicotNot Available
NavicalmNot Available
PostafenNot Available
Sea-LegsNot Available
Brand mixtures
NameLabellerIngredients
Antivert TabPfizer Canada Inc
Salts
Name/CASStructureProperties
Meclizine Hydrochloride
Thumb
  • InChI Key: BAAVORPTHSKWGJ-UHFFFAOYNA-N
  • Monoisotopic Mass: 444.173519006
  • Average Mass: 445.424
DBSALT000678
Categories
UNII3L5TQ84570
CAS number569-65-3
WeightAverage: 390.948
Monoisotopic: 390.186276581
Chemical FormulaC25H27ClN2
InChI KeyInChIKey=OCJYIGYOJCODJL-UHFFFAOYSA-N
InChI
InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3
IUPAC Name
1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
SMILES
CC1=CC(CN2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Phenylmethylamine
  • Benzylamine
  • Aralkylamine
  • N-alkylpiperazine
  • Toluene
  • Halobenzene
  • Chlorobenzene
  • Piperazine
  • 1,4-diazinane
  • Aryl halide
  • Aryl chloride
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
PharmacodynamicsMeclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Mechanism of actionAlong with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.
Related Articles
AbsorptionWell absorbed
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic

Route of eliminationNot Available
Half life6 hours
ClearanceNot Available
ToxicitySymptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9318
Blood Brain Barrier+0.9656
Caco-2 permeable+0.6369
P-glycoprotein substrateSubstrate0.7422
P-glycoprotein inhibitor IInhibitor0.8149
P-glycoprotein inhibitor IINon-inhibitor0.8042
Renal organic cation transporterInhibitor0.7859
CYP450 2C9 substrateNon-substrate0.8416
CYP450 2D6 substrateNon-substrate0.5134
CYP450 3A4 substrateNon-substrate0.6059
CYP450 1A2 substrateInhibitor0.806
CYP450 2C9 inhibitorNon-inhibitor0.9698
CYP450 2D6 inhibitorInhibitor0.9521
CYP450 2C19 inhibitorInhibitor0.5209
CYP450 3A4 inhibitorNon-inhibitor0.8896
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.7063
Ames testNon AMES toxic0.8536
CarcinogenicityNon-carcinogens0.9343
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.3803 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.6113
hERG inhibition (predictor II)Inhibitor0.8104
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
Packagers
Dosage forms
FormRouteStrength
Tabletoral12.5 mg/1
Tabletoral25 mg/1
Tabletoral50 mg/1
Tabletoral
Tablet (immediate release)oral25 mg
Tablet (chewable)oral25 mg
Tablet, orally disintegratingoral25 mg/1
Tablet, film coatedoral25 mg/1
Tablet, chewableoral25 mg/1
Tablet, chewableoral25 mg/251
Film, solubleoral25 mg/1
Prices
Unit descriptionCostUnit
Meclizine HCl 100 25 mg tablet Box89.97USD box
Antivert 50 mg tablet2.12USD tablet
Antivert 25 mg tablet1.23USD tablet
Meclizine hcl powder1.04USD g
Vertin-32 tablet0.9USD tablet
Antivert 12.5 mg tablet0.82USD tablet
Meclizine HCl 25 mg tablet0.67USD tablet
Meclizine 12.5 mg tablet0.62USD tablet
Sm motion sicknes 25 mg tablet0.5USD tablet
Meclizine HCl 12.5 mg tablet0.43USD tablet
Dramamine less drowsy tablet0.42USD tablet
Bonamine 25 mg Chewable Tablet0.33USD tablet
Dramamine 50 mg tablet0.28USD tablet
Meclizine 25 mg tablet0.07USD tablet
Medi-meclizine 25 mg tablet0.06USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point217-224U.S. Patent 2,709,169.
water solubility0.1gm/100mlNot Available
logP5.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00103 mg/mLALOGPS
logP5.59ALOGPS
logP6.39ChemAxon
logS-5.6ALOGPS
pKa (Strongest Basic)8.16ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area6.48 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity119.39 m3·mol-1ChemAxon
Polarizability44.87 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-4z60000000-a39cf62803f22b3df281View in MoNA
References
Synthesis Reference

U.S. Patent 2,709,169.

General ReferencesNot Available
External Links
ATC CodesR06AE05R06AE55
AHFS Codes
  • 56:22.08
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AclidiniumAclidinium may increase the anticholinergic activities of Meclizine.
AmphetamineAmphetamine may decrease the sedative activities of Meclizine.
AzelastineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Meclizine.
Benzylpenicilloyl PolylysineMeclizine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Meclizine.
Botulinum Toxin Type AMeclizine may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BMeclizine may increase the anticholinergic activities of Botulinum Toxin Type B.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
BuprenorphineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
CathinoneCathinone may decrease the sedative activities of Meclizine.
Cimetropium BromideMeclizine may increase the anticholinergic activities of Cimetropium Bromide.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
EluxadolineMeclizine may increase the activities of Eluxadoline.
EthanolMeclizine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Meclizine is combined with Glucagon recombinant.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Meclizine.
HydrocodoneMeclizine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Meclizine.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Meclizine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Meclizine.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
MethotrimeprazineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MetyrosineMeclizine may increase the sedative activities of Metyrosine.
MianserinMianserin may increase the anticholinergic activities of Meclizine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
MirabegronThe risk or severity of adverse effects can be increased when Meclizine is combined with Mirabegron.
MirtazapineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MorphineThe risk or severity of adverse effects can be increased when Meclizine is combined with Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
OrphenadrineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
ParaldehydeMeclizine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Paroxetine.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
Potassium ChlorideMeclizine may increase the ulcerogenic activities of Potassium Chloride.
PramipexoleMeclizine may increase the sedative activities of Pramipexole.
PramlintidePramlintide may increase the anticholinergic activities of Meclizine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Meclizine.
RamosetronMeclizine may increase the activities of Ramosetron.
RopiniroleMeclizine may increase the sedative activities of Ropinirole.
RotigotineMeclizine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Meclizine.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Meclizine.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Meclizine.
SuvorexantMeclizine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Meclizine can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
ThalidomideMeclizine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
TiotropiumMeclizine may increase the anticholinergic activities of Tiotropium.
TopiramateThe risk or severity of adverse effects can be increased when Meclizine is combined with Topiramate.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Meclizine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Meclizine.
ZolpidemMeclizine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food Interactions
  • Take with food to reduce irritation. Avoid alcohol.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Oishi R, Shishido S, Yamori M, Saeki K: Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb;349(2):140-4. [PubMed:7513381 ]
  2. Martins MA, Pasquale CP, e Silva PM, Pires AL, Ruffie C, Rihoux JP, Cordeiro RS, Vargaftig BB: Interference of cetirizine with the late eosinophil accumulation induced by either PAF or compound 48/80. Br J Pharmacol. 1992 Jan;105(1):176-80. [PubMed:1350745 ]
  3. Pasquale CP, e Silva PM, Lima MC, Diaz BL, Rihoux JP, Vargaftig BB, Cordeiro RS, Martins MA: Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized rats. Eur J Pharmacol. 1992 Nov 13;223(1):9-14. [PubMed:1362160 ]
  4. Taniguchi K, Masuda Y, Takanaka K: Inhibitory effects of histamine H1 receptor blocking drugs on metabolic activations of neutrophils. J Pharmacobiodyn. 1991 Feb;14(2):87-93. [PubMed:1678430 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on May 23, 2014 15:54