Muscarinic acetylcholine receptor M3
Details
- Name
- Muscarinic acetylcholine receptor M3
- Synonyms
- Not Available
- Gene Name
- CHRM3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009898|Muscarinic acetylcholine receptor M3 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
- Number of residues
- 590
- Molecular Weight
- 66127.445
- Theoretical pI
- 9.62
- GO Classification
- Functionsacetylcholine binding / drug binding / G-protein coupled acetylcholine receptor activity / phosphatidylinositol phospholipase C activity / receptor activityProcessesadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway / cell proliferation / cellular protein modification process / energy reserve metabolic process / G-protein coupled acetylcholine receptor signaling pathway / G-protein coupled receptor signaling pathway / nervous system development / phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway / positive regulation of smooth muscle contraction / regulation of insulin secretion / regulation of vascular smooth muscle contraction / saliva secretion / sensory perception of chemical stimulus / signal transduction / small molecule metabolic process / smooth muscle contraction / synaptic transmission, cholinergicComponentsasymmetric synapse / axon terminus / basolateral plasma membrane / cell junction / dendrite / integral component of plasma membrane / plasma membrane / postsynaptic membrane / synapse
- General Function
- Receptor activity
- Specific Function
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 68-91 105-130 143-164 185-206 230-252 492-514 527-546
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0009899|Muscarinic acetylcholine receptor M3 (CHRM3) ATGACCTTGCACAATAACAGTACAACCTCGCCTTTGTTTCCAAACATCAGCTCCTCCTGG ATACACAGCCCCTCCGATGCAGGGCTGCCCCCGGGAACCGTCACTCATTTCGGCAGCTAC AATGTTTCTCGAGCAGCTGGCAATTTCTCCTCTCCAGACGGTACCACCGATGACCCTCTG GGAGGTCATACCGTCTGGCAAGTGGTCTTCATCGCTTTCTTAACGGGCATCCTGGCCTTG GTGACCATCATCGGCAACATCCTGGTAATTGTGTCATTTAAGGTCAACAAGCAGCTGAAG ACGGTCAACAACTACTTCCTCTTAAGCCTGGCCTGTGCCGATCTGATTATCGGGGTCATT TCAATGAATCTGTTTACGACCTACATCATCATGAATCGATGGGCCTTAGGGAACTTGGCC TGTGACCTCTGGCTTGCCATTGACTACGTAGCCAGCAATGCCTCTGTTATGAATCTTCTG GTCATCAGCTTTGACAGATACTTTTCCATCACGAGGCCGCTCACGTACCGAGCCAAACGA ACAACAAAGAGAGCCGGTGTGATGATCGGTCTGGCTTGGGTCATCTCCTTTGTCCTTTGG GCTCCTGCCATCTTGTTCTGGCAATACTTTGTTGGAAAGAGAACTGTGCCTCCGGGAGAG TGCTTCATTCAGTTCCTCAGTGAGCCCACCATTACTTTTGGCACAGCCATCGCTGCTTTT TATATGCCTGTCACCATTATGACTATTTTATACTGGAGGATCTATAAGGAAACTGAAAAG CGTACCAAAGAGCTTGCTGGCCTGCAAGCCTCTGGGACAGAGGCAGAGACAGAAAACTTT GTCCACCCCACGGGCAGTTCTCGAAGCTGCAGCAGTTACGAACTTCAACAGCAAAGCATG AAACGCTCCAACAGGAGGAAGTATGGCCGCTGCCACTTCTGGTTCACAACCAAGAGCTGG AAACCCAGCTCCGAGCAGATGGACCAAGACCACAGCAGCAGTGACAGTTGGAACAACAAT GATGCTGCTGCCTCCCTGGAGAACTCCGCCTCCTCCGACGAGGAGGACATTGGCTCCGAG ACGAGAGCCATCTACTCCATCGTGCTCAAGCTTCCGGGTCACAGCACCATCCTCAACTCC ACCAAGTTACCCTCATCGGACAACCTGCAGGTGCCTGAGGAGGAGCTGGGGATGGTGGAC TTGGAGAGGAAAGCCGACAAGCTGCAGGCCCAGAAGAGCGTGGACGATGGAGGCAGTTTT CCAAAAAGCTTCTCCAAGCTTCCCATCCAGCTAGAGTCAGCCGTGGACACAGCTAAGACT TCTGACGTCAACTCCTCAGTGGGTAAGAGCACGGCCACTCTACCTCTGTCCTTCAAGGAA GCCACTCTGGCCAAGAGGTTTGCTCTGAAGACCAGAAGTCAGATCACTAAGCGGAAAAGG ATGTCCCTGGTCAAGGAGAAGAAAGCGGCCCAGACCCTCAGTGCGATCTTGCTTGCCTTC ATCATCACTTGGACCCCATACAACATCATGGTTCTGGTGAACACCTTTTGTGACAGCTGC ATACCCAAAACCTTTTGGAATCTGGGCTACTGGCTGTGCTACATCAACAGCACCGTGAAC CCCGTGTGCTATGCTCTGTGCAACAAAACATTCAGAACCACTTTCAAGATGCTGCTGCTG TGCCAGTGTGACAAAAAAAAGAGGCGCAAGCAGCAGTACCAGCAGAGACAGTCGGTCATT TTTCACAAGCGCGCACCCGAGCAGGCCTTGTAG
- Chromosome Location
- 1
- Locus
- 1q43
- External Identifiers
Resource Link UniProtKB ID P20309 UniProtKB Entry Name ACM3_HUMAN GenBank Protein ID 32324 GenBank Gene ID X15266 GenAtlas ID CHRM3 HGNC ID HGNC:1952 - General References
- Peralta EG, Ashkenazi A, Winslow JW, Smith DH, Ramachandran J, Capon DJ: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J. 1987 Dec 20;6(13):3923-9. [Article]
- Bonner TI, Young AC, Brann MR, Buckley NJ: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron. 1988 Jul;1(5):403-10. [Article]
- Kitano T, Liu YH, Ueda S, Saitou N: Human-specific amino acid changes found in 103 protein-coding genes. Mol Biol Evol. 2004 May;21(5):936-44. Epub 2004 Mar 10. [Article]
- Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Speek M: Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. Mol Cell Biol. 2001 Mar;21(6):1973-85. [Article]
- Yang J, Williams JA, Yule DI, Logsdon CD: Mutation of carboxyl-terminal threonine residues in human m3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization. Mol Pharmacol. 1995 Sep;48(3):477-85. [Article]
- Weber S, Thiele H, Mir S, Toliat MR, Sozeri B, Reutter H, Draaken M, Ludwig M, Altmuller J, Frommolt P, Stuart HM, Ranjzad P, Hanley NA, Jennings R, Newman WG, Wilcox DT, Thiel U, Schlingmann KP, Beetz R, Hoyer PF, Konrad M, Schaefer F, Nurnberg P, Woolf AS: Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like Syndrome. Am J Hum Genet. 2011 Nov 11;89(5):668-74. doi: 10.1016/j.ajhg.2011.10.007. [Article]
- Patowary S, Alvarez-Curto E, Xu TR, Holz JD, Oliver JA, Milligan G, Raicu V: The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane. Biochem J. 2013 Jun 1;452(2):303-12. doi: 10.1042/BJ20121902. [Article]
- Iverson HA, Fox D 3rd, Nadler LS, Klevit RE, Nathanson NM: Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal. J Biol Chem. 2005 Jul 1;280(26):24568-75. Epub 2005 May 2. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00496 Darifenacin approved, investigational yes antagonist Details DB13720 Diphemanil approved, vet_approved, withdrawn yes antagonist Details DB00185 Cevimeline approved yes agonist Details DB00334 Olanzapine approved, investigational unknown antagonist Details DB00383 Oxyphencyclimine approved yes antagonist Details DB00505 Tridihexethyl withdrawn yes antagonist Details DB00517 Anisotropine methylbromide approved yes antagonist Details DB00572 Atropine approved, vet_approved yes antagonist Details DB00725 Homatropine methylbromide approved yes antagonist Details DB00767 Benzquinamide withdrawn yes antagonist Details DB01069 Promethazine approved, investigational unknown antagonist Details DB01231 Diphenidol approved, investigational, withdrawn yes antagonist Details DB01403 Methotrimeprazine approved, investigational unknown antagonist Details DB01409 Tiotropium approved yes antagonist Details DB01591 Solifenacin approved yes antagonist Details DB01062 Oxybutynin approved, investigational yes antagonist Details DB01036 Tolterodine approved, investigational yes antagonist Details DB05752 ALKS 27 investigational unknown Details DB00332 Ipratropium approved, experimental yes antagonist Details DB00622 Nicardipine approved, investigational unknown antagonist Details DB06702 Fesoterodine approved yes antagonist Details DB01224 Quetiapine approved unknown antagonist Details DB00246 Ziprasidone approved unknown antagonist Details DB00363 Clozapine approved unknown antagonist Details DB01338 Pipecuronium approved unknown antagonist Details DB01337 Pancuronium approved unknown antagonist Details DB00280 Disopyramide approved unknown antagonist Details DB00342 Terfenadine approved, withdrawn unknown antagonist Details DB00424 Hyoscyamine approved unknown antagonist Details DB01239 Chlorprothixene approved, experimental, investigational, withdrawn no antagonist Details DB01142 Doxepin approved, investigational unknown antagonist Details DB01151 Desipramine approved, investigational no antagonist Details DB00458 Imipramine approved no antagonist Details DB00434 Cyproheptadine approved unknown antagonist Details DB00835 Brompheniramine approved unknown antagonist Details DB00809 Tropicamide approved, investigational unknown antagonist Details DB00747 Scopolamine approved, investigational yes antagonist Details DB00387 Procyclidine approved yes antagonist Details DB00376 Trihexyphenidyl approved unknown antagonist Details DB01226 Mivacurium approved no antagonist Details DB01085 Pilocarpine approved, investigational yes agonist Details DB00202 Succinylcholine approved unknown agonist Details DB00934 Maprotiline approved, investigational no antagonist Details DB04843 Mepenzolate approved yes antagonist Details DB01625 Isopropamide approved, vet_approved yes antagonist Details DB06709 Methacholine approved, investigational yes agonist Details DB00193 Tramadol approved, investigational unknown antagonist Details DB00462 Methscopolamine bromide approved unknown antagonist Details DB08897 Aclidinium approved yes antagonist Details DB00477 Chlorpromazine approved, investigational, vet_approved unknown antagonist Details DB00408 Loxapine approved unknown binder Details DB00986 Glycopyrronium approved, investigational, vet_approved yes antagonist Details DB09076 Umeclidinium approved yes antagonist Details DB06787 Hexocyclium approved yes antagonist Details DB09300 Butylscopolamine approved, investigational, vet_approved yes antagonist Details DB09167 Dosulepin approved yes antagonist Details DB09262 Imidafenacin investigational yes antagonist Details DB03128 Acetylcholine approved, investigational unknown Details DB00599 Thiopental approved, vet_approved unknown Details DB00411 Carbamoylcholine approved unknown agonist Details DB04365 Arecoline experimental unknown Details DB01019 Bethanechol approved yes agonist Details DB11181 Homatropine approved yes antagonist Details DB06153 Pizotifen approved unknown antagonist Details DB12278 Propiverine approved, investigational yes antagonist Details DB11235 Thonzylamine approved unknown antagonist Details DB13581 Rociverine experimental yes antagonist Details DB09089 Trimebutine approved yes antagonist Details DB14185 Aripiprazole lauroxil approved, investigational no Details DB00502 Haloperidol approved unknown Details DB01238 Aripiprazole approved, investigational unknown ligand Details DB00209 Trospium approved unknown Details DB00940 Methantheline approved, investigational unknown Details DB00804 Dicyclomine approved unknown antagonist Details DB09185 Viloxazine approved, investigational, withdrawn unknown antagonist Details DB00340 Metixene approved yes antagonist Details DB00366 Doxylamine approved, vet_approved unknown antagonist Details DB00777 Propiomazine approved unknown antagonist Details DB00543 Amoxapine approved unknown antagonist Details DB00726 Trimipramine approved unknown binder Details DB00454 Meperidine approved unknown binder Details DB00568 Cinnarizine approved, investigational unknown binder Details DB01221 Ketamine approved, vet_approved unknown binder Details DB09194 Etoperidone withdrawn unknown antagonist Details DB11855 Revefenacin approved, investigational yes antagonist Details DB00321 Amitriptyline approved unknown ligand Details DB00715 Paroxetine approved, investigational unknown inhibitor Details DB00540 Nortriptyline approved unknown antagonist Details