Identification
NameDoxylamine
Accession NumberDB00366  (APRD00937)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. [PubChem]

Structure
Thumb
Synonyms
2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine
2-Dimethylaminoethoxyphenylmethyl-2-picoline
Dossilamina
Doxilamina
Doxilminio
Doxylaminum
N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine
Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether
External IDs Not Available
Product Ingredients
IngredientUNIICASInChI KeyDetails
Doxylamine succinateV9BI9B5YI2 562-10-7KBAUFVUYFNWQFM-UHFFFAOYSA-NDetails
Product Images
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select Sleep AidTablet25 mg/1Oral7 Eleven2014-08-05Not applicableUs
Care One Sleep AidTablet25 mg/1OralAmerican Sales Company2004-06-29Not applicableUs
Careone Nighttime Sleep AidTablet25 mg/1OralAmerican Sales Company2016-05-06Not applicableUs
Equaline Sleep AidTablet25 mg/1OralSupervalu2004-08-10Not applicableUs
Good Neighbor Pharmacy Sleep AidTablet25 mg/1OralAmerisource Bergen1997-06-26Not applicableUs
Good Sense Sleep AidTablet25 mg/1OralL. Perrigo Company1997-04-14Not applicableUs
Harris Teeter Sleep AidTablet25 mg/1OralHarris Teeter2015-11-21Not applicableUs
Health Mart Sleep AidTablet25 mg/1OralMc Kesson2011-11-21Not applicableUs
Healthy Accents Sleep AidTablet25 mg/1OralDza Brands,2011-06-06Not applicableUs
Kirkland Signature Sleep AidTablet25 mg/1OralCostco Wholesale2003-06-27Not applicableUs
Leader Sleep AidTablet25 mg/1OralCardinal Health1997-10-21Not applicableUs
Nighttime Fast Sleep AidTablet25 mg/1OralFred's2002-04-112016-02-26Us
Nighttime Sleep AidTablet25 mg/1OralCvs Health1997-07-23Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralCvs Health2002-04-11Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralBetter Living Brands2002-04-11Not applicableUs21130 0386 27 nlmimage10 e938f4e7
Nighttime Sleep AidTablet25 mg/1OralKroger2014-07-15Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralGreat Lakes Wholesale, Marketing, and Sales, Inc.2002-04-11Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralWalmart Stores2002-04-11Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralHyvee2014-12-04Not applicableUs
Nighttime SleepaidTablet25 mg/1OralWestern Family Foods1997-11-11Not applicableUs
Sambrosa Sweet Dreams NighttimeSyrup9.75 mg/5mLOralSambrosa Care Inc.2015-07-01Not applicableUs
Sleep AidTablet25 mg/1OralHannaford Brothers Company1997-02-07Not applicableUs
Sleep AidTablet25 mg/1OralH.E.B.1998-05-06Not applicableUs
Sleep AidTablet25 mg/1OralMeijer Distribution1997-02-21Not applicableUs
Sleep AidTablet25 mg/1OralCardinal Health2002-04-11Not applicableUs
Sleep AidTablet25 mg/1OralHyvee1998-09-01Not applicableUs
Sleep AidTablet25 mg/1OralCostco Wholesale2002-04-11Not applicableUs
Sleep AidTablet25 mg/1OralSupervalu2002-04-11Not applicableUs
Sleep AidTablet25 mg/1OralFred's2002-04-11Not applicableUs
Sleep AidTablet25 mg/1OralSunmark (Mckesson)2002-04-11Not applicableUs
Sleep AidTablet25 mg/1OralRite Aid2001-04-11Not applicableUs
Sleep AidTablet25 mg/1OralKroger1997-05-02Not applicableUs
Sleep AidTablet25 mg/1OralArmy + Air Force Exchange Service2002-04-11Not applicableUs
Sleep Aid NighttimeTablet25 mg/1OralCardinal Health2002-04-11Not applicableUs
Sleep Aid NighttimeTablet25 mg/1OralMc Kesson (Health Mart)2002-04-11Not applicableUs
Sleep-aidTablet25 mg/1OralH.E.B.2002-04-11Not applicableUs
Smart Sense Sleep AidTablet25 mg/1OralKmart Corporation2010-12-29Not applicableUs
Sunmark Sleep AidTablet25 mg/1OralMc Kesson2003-08-15Not applicableUs
Topcare Sleep AidTablet25 mg/1OralTopco Associates1997-01-29Not applicableUs
Unisom SleeptabsTablet25 mg/1OralChattem, Inc.2016-01-15Not applicableUs
Unisom SleeptabsTablet25 mg/1OralChattem, Inc.1978-10-18Not applicableUs
Unisom-2 TabletsTablet25 mgOralPaladin Labs Inc1987-12-31Not applicableCanada
Wal Som Nighttime Sleep AidTablet25 mg/1OralWalgreen1999-03-05Not applicableUs
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
7 Select Night Time ReliefCapsule, gelatin coatedOral7 Eleven2014-04-17Not applicableUs
Acetaminophen Dextromethorphan Hbr Doxylamine Succinate Phenylephrine HClCapsule, liquid filledOralCvs Pharmacy,inc2017-07-07Not applicableUs
Acetaminophen Dextromethorphan Hydrobromide and Doxylamine SuccinateCapsule, liquid filledOralJ.P. BUSINESS ENTERPRISE2014-12-01Not applicableUs
Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine HydrochlorideCapsule, liquid filledOralGranules India Limited2017-07-07Not applicableUs
Acetaminophen, Dextromethorphan Hydrobromide, and Doxylamine SuccinateCapsule, liquid filledOralSpirit Pharmaceuticals, Llc2009-10-15Not applicableUs
Acetaminophen,dextromethorphan,doxylamineCapsule, liquid filledOralAgile Pharmachem2014-05-01Not applicableUs
Acetaminophen/pseudoephedrine/dextromethorphan/doxylamineCapsuleOralApotex CorporationNot applicableNot applicableCanada
Alka-seltzer Plus Day and Night Cold and Flu FormulaKitBayer Health Care Llc, Consumer Care2013-10-30Not applicableUs
Alka-seltzer Plus Day and Night Multi-symptom Cold and Flu FormulaKitBayer Health Care Llc, Consumer Care2012-05-30Not applicableUs
Alka-seltzer Plus Day and Night Severe Cold and FluKitBayer2014-07-01Not applicableUs
Alka-seltzer Plus Maximum Strength Day and Night Cold and FluKitOralBayer Health Care Llc.2017-05-22Not applicableUs
Alka-seltzer Plus Maximum Strength Night Cold and FluCapsule, liquid filledOralBayer Health Care Llc.2017-06-19Not applicableUs
Alka-seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and NightKitOralBayer Health Care Llc.2017-06-12Not applicableUs
Alka-seltzer Plus Maximum Strength Severe Sinus, Allergy and CoughCapsule, liquid filledOralBayer Health Care Llc.2017-06-26Not applicableUs
Alka-seltzer Plus Multi-smptom Cold and Flu NightCapsule, liquid filledOralBayer2016-07-01Not applicableUs
Alka-seltzer Plus Multi-symptom Cold and Flu Day and Night Liquid GelsKitOralBayer2016-07-15Not applicableUs
Alka-seltzer Plus Multi-symptom Cold NightTablet, effervescentOralBayer Health Care Llc.2017-07-15Not applicableUs
Alka-seltzer Plus Night Cold and Flu FormulaCapsule, liquid filledOralBayer Health Care Llc, Consumer Care2013-07-08Not applicableUs
Alka-seltzer Plus Night Cold Formula (lemon)Tablet, effervescentOralBayer2008-04-30Not applicableUs
Alka-seltzer Plus Night Cold MedicineTablet, effervescentOralBayer Health Care Llc, Consumer Care2010-08-01Not applicableUs
Alka-seltzer Plus Night Severe Cold and FluPowder, for solutionOralBayer2014-04-17Not applicableUs
Alka-seltzer Plus Severe Allergy Sinus Congestion and Headache FormulaCapsule, liquid filledOralBayer Health Care Llc, Consumer Care2012-08-01Not applicableUs
Alka-seltzer Plus Severe Cold and Cough NightLiquidOralBayer Health Care Llc.2015-07-31Not applicableUs
Alka-seltzer Plus Severe Cough Mucus and Congestion Day and NightKitOralBayer Health Care Llc.2017-05-30Not applicableUs
Alka-seltzer Plus Severe Sinus Congestion and Cough Day and NightKitBayer Health Care Llc, Consumer Care2013-10-30Not applicableUs
Alka-seltzer Plus Severe Sinus Congestion and Cough Liquid Gels NightCapsule, liquid filledOralBayer Health Care Llc.2017-02-27Not applicableUs
Alka-seltzer Plus Severe Sinus Congestion, Allergy and CoughCapsule, liquid filledOralBayer Health Care Llc, Consumer Care2013-10-30Not applicableUs
All NiteSolutionOralMajor2012-11-19Not applicableUs
All-nite Cold and FluLiquidOralMajor2009-02-18Not applicableUs
Allergy and CoughCapsule, liquid filledOralWestern Family Foods2014-03-28Not applicableUs
Apo-doxylamine/b6Tablet, delayed releaseOralApotex CorporationNot applicableNot applicableCanada
Aurophen Cold Multi SymptomLiquidOralAurohealth LLC2015-04-30Not applicableUs
Auroquil Cold and Flu Nighttime ReliefSolutionOralAurohealth LLC2015-07-27Not applicableUs
Auroquil Cough Nighttime Cough ReliefSolutionOralAurohealth LLC2015-07-27Not applicableUs
Auroquil Severe Cold and Flu Nighttime ReliefSolutionOralAurohealth LLC2015-05-31Not applicableUs
Aurotussin Maximum Strength Daytime and Nighttime Cough ReliefKitAurohealth LLC2016-05-27Not applicableUs
Being Well Cold and Flu Relief PMLiquidOralSave A Lot Food Stores, Ltd.2011-10-12Not applicableUs
Being Well Cold Flu Relief PM Multi SymptomLiquidOralSave A Lot Food Stores, Ltd.2006-11-15Not applicableUs
Being Well Night Time Cold and FluSolutionOralSave A Lot Food Stores, Ltd.2015-09-14Not applicableUs
Buckley's Cold & Sinus NightTabletOralThe Buckley's CompanyNot applicableNot applicableCanada
Buckley's Complete Nighttime SoftgelsCapsuleOralThe Buckley's Company2010-08-02Not applicableCanada
Buckley's Nighttime Cold and SinusCapsuleOralThe Buckley's Company2008-07-21Not applicableCanada
Care One Cold Mutli SymptomSolutionOralAmerican Sales Company2015-10-19Not applicableUs
Careone Allergy and Cough Severe Sinus CongestionCapsule, liquid filledOralAmerican Sales Company2016-07-06Not applicableUs
Careone Cold and CoughLiquidOralAmerican Sales Company2005-10-28Not applicableUs
Careone Cold MaxSolutionOralAmerican Sales Company2016-03-30Not applicableUs
Careone Daytime Nighttime Cold and FluKitAmerican Sales Company2016-11-02Not applicableUs
Careone Daytime Nighttime Cold Flu ReliefKitAmerican Sales Company2014-09-08Not applicableUs
Careone Night Time Cold and FluSolutionOralAmerican Sales Company2016-04-11Not applicableUs
Careone Nighttime Cold and FluSolutionOralAmerican Sales Company2016-04-15Not applicableUs
Careone Nighttime CoughSolutionOralAmerican Sales Company2004-05-18Not applicableUs
Careone Nighttime Severe Cold and FluSolutionOralAmerican Sales Company2016-04-11Not applicableUs
Careone Nitetime Cold Flu ReliefLiquidOralAmerican Sales Company2013-08-13Not applicableUs
Careone Nitetime Severe Cold Flu ReliefSolutionOralAmerican Sales Company2015-10-12Not applicableUs
Careone Severe Sinus CongestionCapsule, liquid filledOralAmerican Sales Company2014-08-30Not applicableUs
Careone Tussin DM Nighttime CoughSolutionOralAmerican Sales Company2016-08-31Not applicableUs
Circle K Nighttime Cold and FluCapsule, liquid filledOralLil' Drug Store Products, Inc.2014-11-01Not applicableUs
CleartimeCapsule, liquid filledOralHyvee2015-02-16Not applicableUs
Cold & FluCapsule; KitOralVita Health Products Inc2012-08-14Not applicableCanada
Cold & Flu NighttimeLiquidOralArrow Otc Company2007-12-072011-08-03Canada
Cold & Flu Relief NighttimeCapsuleOralVita Health Products IncNot applicableNot applicableCanada
Cold & Sinus Liquid CapsulesCapsule; KitOralVita Health Products Inc2016-06-01Not applicableCanada
Cold and CoughSolutionOralH.E.B.2014-07-14Not applicableUs
Cold and Cough NighttimeLiquidOralCvs Health2007-07-28Not applicableUs
Cold and Cough Nighttime Cool BlastLiquidOralQuality Choice (Chain Drug Marketing Association, Inc.)2014-06-30Not applicableUs
Cold and FluCapsule, gelatin coatedOralHyvee2014-03-24Not applicableUs
Cold and Flu Day NightKitHyvee2014-10-14Not applicableUs
Cold and Flu Daytime NighttimeKitL&R Distributors, Inc.2007-09-19Not applicableUs
Cold and Flu Daytime, Nighttime SevereKitWalmart Stores2015-08-01Not applicableUs
Cold and Flu Daytime, Nighttime, Maximum StrengthKitWalgreen2015-08-01Not applicableUs
Cold and Flu Daytime, Nighttime, Multi-symptomKitWalgreen2015-03-01Not applicableUs
Cold and Flu Medicine - Night Time FormulaCapsuleOralPharmetics (2011) Inc.2006-04-102010-07-12Canada
Cold and Flu Multi-symptom Daytime NighttimeKitArmy + Air Force Exchange Service2013-11-01Not applicableUs
Cold and Flu NighttimeCapsuleOralL&R Distributors, Inc.2007-09-10Not applicableUs
Cold and Flu Nighttime DSolutionOralWalgreen2014-02-05Not applicableUs
Cold and Flu Nighttime Multi SymptomCapsule, liquid filledOralL&R Distributors, Inc.2015-03-01Not applicableUs
Cold and Flu Nighttime Multi-symptomCapsule, liquid filledOralCardinal Health2015-03-01Not applicableUs
Cold and Flu Nighttime ReliefLiquidOralFred's2015-07-31Not applicableUs
Cold and Flu Nighttime/multi-symptomCapsule, liquid filledOralWalgreen2015-03-01Not applicableUs
Cold and Flu ReliefLiquidOralWalgreen2012-08-07Not applicableUs
Cold and Flu Relief Daytime NighttimeKitRite Aid2012-10-13Not applicableUs
Cold and Flu Relief Multi SymptomKitOralWin Co Foods, Llc,2014-12-31Not applicableUs
Cold and Flu Relief Multi Symptom NighttimeCapsule, liquid filledOralWin Co Foods, Llc,2014-12-31Not applicableUs
Cold and Flu Relief Multi-symptomKitArmy + Air Force Exchange Service2015-03-01Not applicableUs
Cold and Flu Relief Multi-symptom, Day, NightKitLnk International, Inc.2015-03-01Not applicableUs
Cold and Flu Relief Multi-symptom, NighttimeCapsule, liquid filledOralArmy + Air Force Exchange Service2007-09-10Not applicableUs
Cold and Flu Relief NighttimeCapsule, liquid filledOralAmerisource Bergen (Good Neighbor Pharmacy) 461222015-11-30Not applicableUs
Cold and Flu Relief Nighttime Multi SymptomCapsule, liquid filledOralP And L Development Of New York Corporation (Ready In Case)2014-07-31Not applicableUs
Cold and Flu Relief Nighttime, Multi-symptomCapsule, liquid filledOralArmy + Air Force Exchange Service2015-03-01Not applicableUs
Cold and Flu Relief Non-drowsy / Daytime Severe / Nighttime SevereKitCvs Health2015-08-01Not applicableUs
Cold and Flu Severe, Nighttime, Maximum StrengthTablet, film coatedOralWalgreen2015-08-01Not applicableUs
Cold and Sinus Nighttime ReliefTabletOralVita Health Products IncNot applicableNot applicableCanada
Cold and Sinus Relief ComboKit; TabletOralVita Health Products Inc2013-06-24Not applicableCanada
Cold Flu ReliefLiquidOralPerrigo International1997-01-09Not applicableCanada
Cold Max NighttimeLiquidOralP & L Development, LLC2016-10-31Not applicableUs
Cold Multi SymptomSolutionOralH.E.B.2015-12-21Not applicableUs
Cold Relief Multi Symptom NighttimeLiquidOralCvs Health2015-09-30Not applicableUs
Cold/flu MedicineLiquidOralPerrigo International2008-09-012014-02-24Canada
Complete Liquid CapsulesCapsule; KitOralVita Health Products Inc2012-12-10Not applicableCanada
Complete Liquid Capsules Nighttime ReliefCapsuleOralVita Health Products Inc2017-05-25Not applicableCanada
Conrx NighttimeTabletOralEagle Distributors,Inc.2014-02-10Not applicableUs
Contac Cold and Flu Cooling ReliefLiquidOralMeda Pharmaceuticals Ltd2012-07-15Not applicableUs
Core Values Night Time ReliefSolutionOralHarmon Stores2017-01-17Not applicableUs
Coricidin Hbp Nighttime Multi-symptom ColdLiquidOralBayer Health Care Llc.2015-11-20Not applicableUs
CoughSolutionOralHyvee2016-03-03Not applicableUs
Cough and Sore Throat Multi SymptomLiquidOralMeijer Distribution2005-10-05Not applicableUs
Cough and Sore Throat NighttimeLiquidOralKinray2006-08-28Not applicableUs
Cough and Sore Throat Pain ReliefLiquidOralHyvee2008-07-20Not applicableUs
Cough Day NightKitHyvee2015-02-18Not applicableUs
Cough Multi SymptomLiquidOralKinray2006-08-28Not applicableUs
Cough Nighttime Cough ReliefSolutionOralChain Drug Consortium2015-07-27Not applicableUs
Cough Relief Daytime NighttimeKitWalgreen2012-09-06Not applicableUs
Cough Relief NighttimeLiquidOralWalgreen2002-08-16Not applicableUs
Cvs Daytime Cold and Flu Relief and Nighttime Cold and Flu ReliefKitPura Cap Pharmaceutical Llc.2016-06-30Not applicableUs
Cvs Health Nighttime Cold and Flu Relief Single Serve Cups Cold and Flu Nighttime ReliefPowder, for solutionOralCvs Health2016-08-15Not applicableUs
Cvs Nighttime Cold/flu ReliefLiquidOralCvs Health2009-07-09Not applicableUs
DalmacolLiquidOralLaboratoire Riva Inc1997-03-26Not applicableCanada
Day Cold and Flu Plus and Nighttime Cold and Flu PlusKitPura Cap Pharmaceutical Llc.2016-07-28Not applicableUs
Day Night Cold and FluKitHyvee2014-07-02Not applicableUs
Day Relief Night Relief FreeKitWestern Family Foods2007-08-17Not applicableUs
Day Relief Night Relief Sinus PEKitWestern Family Foods2007-11-16Not applicableUs
Day Time and Night Time Cold and Flu FormulaKitPura Cap Pharmaceutical Llc.2016-07-20Not applicableUs
Day Time and Night Time Sinus and CongestionKitWalgreens2014-09-01Not applicableUs
Day Time Night TimeKitShopko Stores Operating2013-09-19Not applicableUs
Day Time Night Time Cold and FluKitWalgreens2013-03-01Not applicableUs
Day Time Night Time Sinus ReliefKitWalgeens Company2013-03-01Not applicableUs
Day Time Nighttime CoughKitHyvee2012-08-30Not applicableUs
Day-time Night-timeKitChain Drug Consortium2010-07-12Not applicableUs
Daytime and Nighttime Cold and FluKitPura Cap Pharmaceutical Llc.2017-07-12Not applicableUs
Daytime and Nighttime Cold and Flu ReliefKitChain Drug Consortium2015-07-09Not applicableUs
Daytime and Nighttime Cold and Flu Relief PlusKitChain Drug Consortium2015-09-17Not applicableUs
Daytime and Nighttime Cough ReliefKitCvs Health2016-05-02Not applicableUs
Daytime and NitetimeKitPura Cap Pharmaceutical Llc.2016-06-27Not applicableUs
Daytime Cold and Flu and Nighttime Cold and FluKitKmart Corporation2017-07-12Not applicableUs
Daytime Cold and Flu Severe and Nighttime Cold and Flu SevereKitTopco Associates2016-06-28Not applicableUs
Daytime Cough Nighttime CoughKitCvs Health2012-08-07Not applicableUs
Daytime NighttimeKitShopko Stores Operating2014-06-03Not applicableUs
Daytime Nighttime CleartimeKitHyvee2015-02-07Not applicableUs
Daytime Nighttime Cold and FluKitSafeway2014-06-30Not applicableUs
Daytime Nighttime Cold and Flu ReliefKitRite Aid2014-06-13Not applicableUs
Daytime Nighttime Cold and Flu Relief Multi-symptomKitFamily Dollar (FAMILY WELLNESS)2013-06-30Not applicableUs
Daytime Nighttime Cold Flu ReliefKitSafeway2013-07-15Not applicableUs
Daytime Nighttime Cold/fluKitQuality Choice (Chain Drug Marketing Association, Inc.)2013-01-15Not applicableUs
Daytime Nighttime Multi Symptom Cold and Flu ReliefKitShopko Stores Operating2012-05-10Not applicableUs
Daytime Nighttime Multi Symptom Cold Flu ReliefKitCvs Health2006-08-02Not applicableUs
Daytime Nighttime Severe Cold and FluKitHyvee2015-09-13Not applicableUs
Daytime Nighttime Severe Cold and Flu ReliefKitRite Aid2015-07-24Not applicableUs
Daytime Nighttime Sinus ReliefKitHyvee2013-11-30Not applicableUs
Daytime Nite TimeKitKroger2007-08-31Not applicableUs
Daytime NitetimeKitKroger2014-05-31Not applicableUs
Daytime Nitetime Cold and FluKitKroger2014-11-03Not applicableUs
Daytime Nitetime Cold and Flu ReliefKitCare One (American Sales Company)2012-08-14Not applicableUs
Daytime Nitetime Cold Flu ReliefKitOralCare One (American Sales Company)2014-10-30Not applicableUs
Daytime Nitetime SinusKitMeijer Distribution2007-08-10Not applicableUs
Daytime Nitetime Sinus ReliefKitTopcare (Topco Associates Llc)2013-01-15Not applicableUs
Daytime PE NitetimeKitPublix Supermarkets, Inc.2008-10-15Not applicableUs
Daytime Sinus Relief and Nighttime Sinus ReliefKitPura Cap Pharmaceutical Llc.2016-08-02Not applicableUs
Daytime/nighttime Cold and Flu Multi-symptom ReliefKitL&R Distributors, Inc.2015-03-01Not applicableUs
Daytime/nitetime Severe Cold and Flu Maximum StrengthKitMeijer Distribution2015-07-13Not applicableUs
Ddm Day Time and Nite Time Cold and FluKitPura Cap Pharmaceutical Llc.2016-06-20Not applicableUs
Delsym Night Time Multi-symptomLiquidOralReckitt Benckiser2011-07-01Not applicableUs
Dg Day Time Cold and Flu Formula and Night Time Cold and Flu FormulaKitPura Cap Pharmaceutical Llc.2016-06-15Not applicableUs
Dg Health Cold and Flu ReliefLiquidOralDolgencorp2009-10-03Not applicableUs
Dg Health Cold and Flu Relief Night TimeCapsule, liquid filledOralDolgencorp2009-11-17Not applicableUs
Dg Health Cold and Flu Relief Nite TimeLiquidOralDolgencorp2009-11-21Not applicableUs
Dg Health Cold MaxSolutionOralDolgencorp2016-05-20Not applicableUs
Dg Health Cough and Sore Throat Nite TimeSolutionOralDolgencorp2010-02-06Not applicableUs
Dg Health Cough Night TimeSolutionOralDolgencorp2009-11-21Not applicableUs
Dg Health Night Time Cold and Flu ReliefSolutionOralDolgencorp2011-08-17Not applicableUs
Dg Health Pain Relief Cold Night TimeSolutionOralDolgencorp2015-09-30Not applicableUs
Dg Health TussinSolutionOralDolgencorp2016-04-25Not applicableUs
DiclectinTablet, delayed releaseOralDuchesnay Inc.1983-12-31Not applicableCanada
DiclegisTablet, delayed releaseOralDuchesnay Inc.2013-05-15Not applicableUs55494 0100 10 nlmimage10 b639db2e
Equaline Daytime and Nighttime Cold and Flu ReliefKitSupervalu2012-08-14Not applicableUs
Equaline Daytime Nighttime Cold and Flu ReliefKitSupervalu2011-07-26Not applicableUs
Equaline Night Time CoughLiquidOralSupervalu2004-09-21Not applicableUs
Equaline NighttimeLiquidOralSupervalu2011-08-04Not applicableUs
Equaline Nighttime Cold and Flu ReliefCapsule, gelatin coatedOralSupervalu2014-02-16Not applicableUs
Equaline Nighttime Cough ReliefSolutionOralSupervalu2014-05-20Not applicableUs
Equaline Nighttime Severe Cold and FluSolutionOralSupervalu2014-07-31Not applicableUs
Equate Daytime NitetimeKitWalmart Stores2008-02-09Not applicableUs
Equate Daytime Nitetime SevereKitWalmart Stores2014-08-12Not applicableUs
Equate Nighttime Liquid CapsulesCapsuleOralIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Equate Nite Time Cold Flu ReliefLiquidOralWalmart Stores2005-11-03Not applicableUs
Equate Nite Time CoughSolutionOralWalmart Stores2002-07-24Not applicableUs
Equate NitetimeCapsule, gelatin coatedOralWalmart Stores2014-01-28Not applicableUs
Equate Nitetime Cold and FluCapsule, liquid filledOralWalmart Stores2006-07-17Not applicableUs
Equate Nitetime DaytimeKitWalmart Stores2013-08-15Not applicableUs
Equate Nitetime SevereSolutionOralWalmart Stores2014-07-27Not applicableUs
Equate Sinus Night TimeCapsule, liquid filledOralWalmart Stores2010-08-04Not applicableUs
Extra Strength Tylenol Cold and Flu NighttimeLiquidOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Family Care Cold and Flu Multi SymptomLiquidOralUnited Exchange Corporation2015-07-30Not applicableUs
Family Care Cold and Flu NighttimeLiquidOralUnited Exchange Corporation2015-07-21Not applicableUs
Family Care Cough NighttimeLiquidOralUnited Exchange Corporation2015-07-20Not applicableUs
Fulton Street Market Cold and FluLiquidOralAccess Business Group2010-07-15Not applicableUs
Fulton Street Market Night Time Cold and FluLiquidOralAccess Business Group2012-08-22Not applicableUs
GlentussSyrupOralGlendale Inc2015-12-05Not applicableUs
Good Neighbor Pharmacy Cold Multi SymptomSolutionOralAmerisource Bergen2015-10-26Not applicableUs
Good Neighbor Pharmacy Cough and Sore ThroatLiquidOralAmerisource Bergen2006-02-14Not applicableUs
Good Neighbor Pharmacy Multi SymptomLiquidOralAmerisource Bergen2014-12-23Not applicableUs
Good Neighbor Pharmacy Night TimeCapsule, liquid filledOralAmerisource Bergen2006-04-19Not applicableUs
Good Neighbor Pharmacy Night Time Cold and FluSolutionOralAmerisource Bergen2011-10-16Not applicableUs
Good Neighbor Pharmacy Night Time CoughSolutionOralAmerisource Bergen2003-06-30Not applicableUs
Good Neighbor Pharmacy Night Time DLiquidOralAmerisource Bergen1994-08-28Not applicableUs
Good Neighbor Pharmacy Night Time SevereSolutionOralAmerisource Bergen2014-01-09Not applicableUs
Good Neighbor Pharmacy Severe Night TimeSolutionOralAmerisource Bergen2015-09-032017-06-20Us
Good Neighbor Pharmacy Severe Sinus CongestionCapsule, liquid filledOralAmerisource Bergen2014-12-21Not applicableUs
Good Neoghbor Pharmacy Tussin DM Max Nighttime CoughSolutionOralAmerisource Bergen2016-08-25Not applicableUs
Good Sense Cough and Sore Throat Night TimeLiquidOralL. Perrigo Company2006-09-14Not applicableUs
Good Sense Daytime Night TimeKitL. Perrigo Company2010-11-17Not applicableUs
Good Sense Night TimeLiquidOralL. Perrigo Company2006-04-07Not applicableUs
Good Sense Night Time Cold and FluSolutionOralL. Perrigo Company2013-01-04Not applicableUs
Good Sense NighttimeSolutionOralL. Perrigo Company2011-08-22Not applicableUs
Good Sense Nighttime CoughSolutionOralL. Perrigo Company2002-11-03Not applicableUs
Good Sense Nighttime Daytime Cold and FluKitL. Perrigo Company2014-01-03Not applicableUs
Good Sense Severe NighttimeSolutionOralL. Perrigo Company2015-10-21Not applicableUs
Good Sense Severe Nighttime Cold and FluLiquidOralL. Perrigo Company2013-11-19Not applicableUs
Good Sense Severe Sinus CongestionCapsule, liquid filledOralL. Perrigo Company2014-01-28Not applicableUs
Harmon Face Values Night Time ReliefSolutionOralHarmon Stores2012-01-13Not applicableUs
Harris Teeter Daytime NighttimeKitHarris Teeter2015-11-21Not applicableUs
Harris Teeter NighttimeSolutionOralHarris Teeter2015-09-24Not applicableUs
Harris Teeter Nighttime Cold and FluCapsule, gelatin coatedOralHarris Teeter2015-11-21Not applicableUs
Health Mart Multi-symptom Cold and Flu Night TimeCapsule, liquid filledOralMc Kesson (Health Mart)2012-04-09Not applicableUs
Health Mart Night Time Cold and FluSolutionOralMc Kesson2012-01-11Not applicableUs
Healthy Accents Cold and CoughLiquidOralDza Brands,2014-03-31Not applicableUs
Healthy Accents Cough and Sore Throat Night TimeLiquidOralDza Brands,2008-02-24Not applicableUs
Healthy Accents Day Time Night TimeKitDza Brands,2008-04-01Not applicableUs
Healthy Accents Daytime Nighttime Cold and FluKitDza Brands,2014-05-30Not applicableUs
Healthy Accents Night Time CoughSolutionOralDza Brands,2008-01-29Not applicableUs
Healthy Accents Nighttime Cold and FluLiquidOralDza Brands,2008-01-29Not applicableUs
Heb Day Time Night Time Severe Cold and FluKitH.E.B.2016-04-14Not applicableUs
Leader Nighttime Cold and FluSolutionOralCardinal Health2016-11-15Not applicableUs
Leader Nighttime CoughSolutionOralCardinal Health2016-11-29Not applicableUs
Leader Nighttime Severe Cold and FluSolutionOralCardinal Health2016-12-01Not applicableUs
Leader Nite TimeSolutionOralCardinal Health2011-11-30Not applicableUs
Leader Nite Time Cold Flu Relief Multi SymptomLiquidOralCardinal Health2006-06-20Not applicableUs
Leader Nite Time CoughLiquidOralCardinal Health2013-04-28Not applicableUs
Leader Nite Time Multi Symptom Cold and Flu ReliefLiquidOralCardinal Health2009-10-05Not applicableUs
Leader Nite Time Multi Symptom Cold Flu ReliefLiquidOralCardinal Health2006-06-29Not applicableUs
Leader Nite Time Severe Cold and FluSolutionOralCardinal Health2013-11-21Not applicableUs
Leader Severe Sinus CongestionCapsule, liquid filledOralCardinal Health2013-11-21Not applicableUs
Lil Drug Store Nyquil Severe Cold and Flu, Max StrengthTablet, coatedOralLil' Drug Store Products, Inc.2016-04-07Not applicableUs
Lortuss DMLiquidOralPoly Pharmaceuticals2011-03-14Not applicableUs
Lortuss LqLiquidOralPoly Pharmaceuticals2011-02-22Not applicableUs
Major Night Time Multi Symptom Cold and Flu ReliefCapsule, liquid filledOralMajor2012-03-01Not applicableUs
Maximum Strength Night Time Cold and Flu ReliefCapsule, liquid filledOralPura Cap Pharmaceutical Llc.2016-06-10Not applicableUs
Maximum Strength Nighttime Cold/flu ReliefCapsule, liquid filledOralPura Cap Pharmaceutical Llc.2016-02-21Not applicableUs
Mckesson Nite TimeLiquidOralMc Kesson2009-07-09Not applicableUs
Mercodol With DecaprynSyrupOralAventis Pharma Ltd.1994-12-312001-07-20Canada
Mersyndol With CodeineTabletOralSanofi Aventis1982-12-31Not applicableCanada
Mucinex Fast-max Day Severe Cold and Night Cold and FluKitReckitt Benckiser2015-07-15Not applicableUs
Mucinex Fast-max Night Time Cold and FluCapsule, liquid filledOralReckitt Benckiser2015-07-15Not applicableUs
Mucinex Sinus - Max Day / NightKitReckitt Benckiser2015-07-15Not applicableUs
Multi Symptom Cold and Flu Relief NighttimeCapsule, liquid filledOralSMART SENSE (Kmart)2016-07-31Not applicableUs
Multi Symptom Nighttime Cold and Flu ReliefCapsule, liquid filledOralChain Drug Consortium2012-11-15Not applicableUs
Multi Symptom NitetimeCapsule, liquid filledOralCare One (American Sales Company)2015-10-31Not applicableUs
Multi-symptom Daytime and Nighttime Cold and Flu Relief PlusKitWalgreens2014-09-01Not applicableUs
Multi-symptom Nighttime Sinus ReliefCapsule, liquid filledOralPura Vation Pharmaceuticals Inc2013-09-152017-01-04Us
Multi-symptom NitetimeCapsule, liquid filledOralP And L Development Of New York Corporation (Ready In Case)2011-10-10Not applicableUs
N - TimeCapsule, liquid filledOralSpirit Pharmaceuticals, Llc2010-05-30Not applicableUs
N - Time SinusCapsule, liquid filledOralSpirit Pharmaceuticals, Llc2010-03-01Not applicableUs
Neocitran Cold & Flu SyrupSyrupOralNovartis2004-07-302007-07-18Canada
Next Cold and Flu NighttimeCapsule, gelatin coatedOralGenomma Lab2016-05-03Not applicableUs
Next Night Severe Cold, Flu and Sore ThroatLiquidOralGenomma Lab2016-06-02Not applicableUs
Next Night Time Cold and Flu ReliefCapsule, liquid filledOralGenomma Lab2015-01-21Not applicableUs
Nicold Medicine for AdultsSyrupOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Night Cold Flu Cough and AllergyCapsule, liquid filledOralHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.2013-05-29Not applicableUs
Night ReliefCapsule, gelatin coatedOralWestern Family Foods2014-02-13Not applicableUs
Night Relief Cold and Flu Liquid CapsulesCapsuleOralBanner Pharmacaps2005-01-052009-08-07Canada
Night Relief CoughLiquidOralWestern Family Foods2002-10-21Not applicableUs
Night Relief FreeLiquidOralWestern Family Foods2009-09-15Not applicableUs
Night Relief Multi Symptom Cold and FluCapsule, liquid filledOralWestern Family Foods2007-05-09Not applicableUs
Night Relief SinusCapsule, liquid filledOralWestern Family Foods2012-07-12Not applicableUs
Night TimeCapsule, gelatin coatedOralShopko Stores Operating2014-06-02Not applicableUs
Night Time CherryLiquidOralDollar General2009-02-172017-06-20Us
Night Time Cherry Pseudo-freeLiquidOralSafeway2009-01-232017-06-03Us
Night Time Cold and FluLiquidOralSafeway1994-07-19Not applicableUs
Night Time Cold and Flu CherryLiquidOralMarc Glassman, Inc.2017-07-15Not applicableUs
Night Time Cold and Flu FormulaCapsule, liquid filledOralPura Cap Pharmaceutical Llc.2016-07-14Not applicableUs
Night Time Cold and Flu Multi SymptomCapsule, liquid filledOralH.E.B.2011-06-10Not applicableUs
Night Time Cold and Flu OriginalLiquidOralMarc Glassman, Inc.2017-07-20Not applicableUs
Night Time Cold and Flu ReadyincaseLiquidOralP & L Development, LLC2014-10-31Not applicableUs
Night Time Cold and Flu ReliefCapsule, liquid filledOralDolgencorp, Inc. (Dollar General & Rexall)2015-08-31Not applicableUs
Night Time Cold and Flu Relief Multi SymptomCapsule, liquid filledOralFred's2015-10-31Not applicableUs
Night Time Cold and Flu SevereCapsule, liquid filledOralTopco Associates2016-06-02Not applicableUs
Night Time Cold and Flue ReliefCapsule, liquid filledOralAllegiant Health2015-03-03Not applicableUs
Night Time Cold MaxLiquidOralDolgencorp2016-03-04Not applicableUs
Night Time Cold/flu Relief CherryLiquidOralKareway Product, Inc.2011-08-26Not applicableUs
Night Time Cold/flu Relief Multi SymptomCapsule, liquid filledOralShopko Stores Operating2012-08-30Not applicableUs
Night Time Cold/flu Relief OriginalLiquidOralKareway Product, Inc.2011-08-26Not applicableUs
Night Time CoughLiquidOralSafeway2015-06-30Not applicableUs
Night Time Cough and Sore Throat Cool BlastSyrupOralCvs Health2009-07-082017-05-12Us
Night Time Cough CherryLiquidOralRite Aid2009-08-112017-06-20Us
Night Time Cough ReliefSolutionOralH.E.B.2003-02-25Not applicableUs
Night Time Day Time Cold and FluKitHyvee2007-09-24Not applicableUs
Night Time GelcapCapsule, liquid filledOralKareway Product, Inc.2011-06-01Not applicableUs
Night Time Liquid Caps Cold Flu Multi SymptomCapsule, liquid filledOralH.E.B.2013-08-14Not applicableUs
Night Time Multi Symptom Cold/flu ReliefCapsule, liquid filledOralFred's2012-07-02Not applicableUs
Night Time Multi Symptom Flu Cold MedicineCapsule, liquid filledOralSalado Sales, Inc.2015-03-01Not applicableUs
Night Time Multi Symptom ReliefCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Night Time Multi-symptom Cold/flu ReliefLiquidOralChain Drug Consortium2012-09-01Not applicableUs
Night Time Original Pseudo-freeLiquidOralSelect Brand2009-07-142017-06-03Us
Night Time Pseudo-freeLiquidOralRite Aid2009-10-16Not applicableUs
Night Time ReliefCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Night Time Severe Cold and Flu ReliefCapsule, liquid filledOralPura Cap Pharmaceutical Llc.2016-06-09Not applicableUs
Night Time SinusCapsule, liquid filledOralFred's2012-12-05Not applicableUs
Night Time Sinus and CongestionCapsule, liquid filledOralChain Drug Consortium2015-10-12Not applicableUs
Night Time Sinus ReliefCapsule, liquid filledOralPura Cap Pharmaceutical Llc.2016-07-15Not applicableUs
Night Time SoftgelsCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Night-time Cherry Multi-symptom Cold/flu ReliefLiquidOralChain Drug Consortium2012-09-01Not applicableUs
Night-time Cough ReliefLiquidOralDiscount Drug Mart2014-10-27Not applicableUs
Night-time Multi-symptom Cold/flu CherryLiquidOralDe Moulas Market Basket2012-10-01Not applicableUs
Night-time Multi-symptom Cold/flu OriginalLiquidOralDe Moulas Market Basket2012-10-01Not applicableUs
Night-time Multi-symptom Cold/flu ReliefLiquidOralDiscount Drug Mart2014-11-19Not applicableUs
Night-time Original Multi-symptom Cold/flu ReliefLiquidOralChain Drug Consortium2012-09-01Not applicableUs
Nightcap Cold and Flu Liquid GelsCapsuleOralAccucaps Industries LimitedNot applicableNot applicableCanada
Nightcap Complete Liquid GelsCapsuleOralAccucaps Industries LimitedNot applicableNot applicableCanada
Nightrelief DayreliefKitWestern Family Foods2012-02-02Not applicableUs
Nightrelief Free Multi Symptom Cold FluLiquidOralWestern Family Foods2006-05-01Not applicableUs
NighttimeLiquidOralHannaford Brothers Company2006-06-21Not applicableUs
Nighttime 325 Liqua CapsCapsuleOralJamp Pharma CorporationNot applicableNot applicableCanada
Nighttime Cold & Flu Liquid CapsulesCapsuleOralVita Health Products Inc1996-12-312008-08-05Canada
Nighttime Cold & Flu ReliefCapsuleOralApotex Corporation2014-09-22Not applicableCanada
Nighttime Cold & Flu Relief SyrupSyrupOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Nighttime Cold and FluSolutionOralShopko Stores Operating2013-08-05Not applicableUs
Nighttime Cold and Flu CherryLiquidOralSelect Brand Dist.2013-12-06Not applicableUs
Nighttime Cold and Flu Extra Strength MedicineLiquidOralJamp Pharma CorporationNot applicableNot applicableCanada
Nighttime Cold and Flu Lil Drug Store ProductsLiquidOralLil' Drug Store Products, Inc.2014-12-01Not applicableUs
Nighttime Cold and Flu Liquid CapsulesCapsuleOralVita Health Products Inc1997-02-192003-11-07Canada
Nighttime Cold and Flu Multi SymptomCapsule, liquid filledOralMc Kesson (Health Mart)2015-12-31Not applicableUs
Nighttime Cold and Flu OriginalLiquidOralMarc Glassman, Inc.2014-08-31Not applicableUs
Nighttime Cold and Flu ReadyincaseLiquidOralP & L Development, LLC2014-11-30Not applicableUs
Nighttime Cold and Flu ReliefLiquidOralWalgreen2011-08-08Not applicableUs
Nighttime Cold and Flu Relief Multi-symptomCapsule, liquid filledOralFamily Dollar (FAMILY WELLNESS)2013-06-30Not applicableUs
Nighttime Cold and Flu Relief PlusCapsuleOralChain Drug Consortium2015-09-23Not applicableUs
Nighttime Cold Flu ReliefCapsule, liquid filledOralLIVE BETTER (The Great Atlantic & Pacific Tea Company)2013-05-31Not applicableUs
Nighttime Cold MaxLiquidOralFamily Dollar2016-06-29Not applicableUs
Nighttime Cold MedicineLiquidOralJamp Pharma CorporationNot applicableNot applicableCanada
Nighttime Cold Multi-symptom Cool BlastLiquidOralAmerisource Bergen (Good Neighbor Pharmacy) 461222011-03-04Not applicableUs
Nighttime CoughLiquidOralWalgreen2002-08-16Not applicableUs
Nighttime Cough All Night Cough ReliefLiquidOralP & L Development, LLC2014-07-31Not applicableUs
Nighttime Cough and Sore Throat LiquidLiquidOralJamp Pharma CorporationNot applicableNot applicableCanada
Nighttime Cough DM Maximum StrengthLiquidOralWin Co Foods, Llc,2016-06-30Not applicableUs
Nighttime Cough ReliefLiquidOralFred's2015-07-31Not applicableUs
Nighttime Cough. Cold. Flu Gel CapsulesCapsuleOralApotex Inc., Private Label DivisionNot applicableNot applicableCanada
Nighttime D Cold and FluLiquidOralHyvee1994-02-14Not applicableUs
Nighttime D Cold and Flu ReliefLiquidOralWalgreen2002-06-19Not applicableUs
Nighttime Daytime CoughKitWalgreen2014-02-25Not applicableUs
Nighttime Liqua CapsCapsuleOralJamp Pharma Corporation2006-02-13Not applicableCanada
Nighttime Maximum Strength Cold and FluCapsule, liquid filledOralChain Drug Marketing Association2016-08-03Not applicableUs
Nighttime Multi SymptomLiquidOralCvs Health2006-06-09Not applicableUs
Nighttime Multi Symptom Cold and Flu ReliefCapsule, liquid filledOralFamily Dollar (FAMILY WELLNESS)2015-08-31Not applicableUs
Nighttime Multi-symptom Cold and Flu ReliefCapsule, liquid filledOralWalgreen2007-09-10Not applicableUs
Nighttime Multi-symptom Flu ColdCapsule, liquid filledOralSalado Sales, Inc.2007-09-10Not applicableUs
Nighttime Relief Severe Cold and FluSolutionOralFred's2015-06-26Not applicableUs
Nighttime SevereSolutionOralShopko Stores Operating2015-09-02Not applicableUs
Nighttime Severe Cold and FluSolutionOralH.E.B.2016-04-11Not applicableUs
Nighttime Severe Cold and Flu ReliefCapsule, liquid filledOralPura Cap Pharmaceutical Llc.2016-07-27Not applicableUs
Nighttime SinusCapsule, liquid filledOralGood Sense (Geiss, Destin & Dunn, Inc.)2012-07-01Not applicableUs
Nighttime Sinus and Congestion ReliefCapsule, liquid filledOralPura Cap Pharmaceutical Llc.2016-07-27Not applicableUs
Nighttime Sinus Multi SymptomCapsule, liquid filledOralChain Drug Consortium2012-10-18Not applicableUs
Nighttime Sinus ReliefCapsule, liquid filledOralHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.2013-06-15Not applicableUs
Nite TimeCapsule, gelatin coatedOralKroger2014-06-21Not applicableUs
Nite Time Cold and FluLiquidOralRite Aid2006-05-09Not applicableUs
Nite Time Cold and Flu ReliefLiquidOralKroger2006-04-05Not applicableUs
Nite Time Cold Flu ReliefLiquidOralWe Care Distributor Inc.2016-08-10Not applicableUs
Nite Time Cold MedicineLiquidOralRij Pharmaceutical Corporation1999-03-16Not applicableUs
Nite Time Cold Medicine Cherry FlavorLiquidOralRij Pharmaceutical Corporation1999-03-16Not applicableUs
Nite Time Cold/flu ReliefCapsule, liquid filledOralNash Finch Company (Our Family)2013-05-31Not applicableUs
Nite Time Day TimeKitKroger2011-11-12Not applicableUs
Nite Time Multi Symptom Cold Flu ReliefLiquidOralKroger2009-08-05Not applicableUs
Nite Time Multi Symptom Cold/fluCapsule, liquid filledOralKroger2006-05-09Not applicableUs
Nite Time Severe Cold and Flu Maximum StrengthTablet, film coatedOralMeijer Distribution2015-08-01Not applicableUs
Nite-time Cold and Flu Multi-symptom ReliefCapsule, liquid filledOralPreferred Plus (Kinray)2013-03-31Not applicableUs
Nite-time Cold/flu OriginalLiquidOralSalado Sales, Inc.2012-01-16Not applicableUs
Nite-timecold/flu Cherry Cold/flu CherryLiquidOralSalado Sales, Inc.2012-01-31Not applicableUs
Nitecap Sinus Liquid GelsCapsuleOralAccucaps Industries LimitedNot applicableNot applicableCanada
NitetimeLiquidOralKroger1994-05-09Not applicableUs
Nitetime Cold and FluCapsule, liquid filledOralKroger2014-10-06Not applicableUs
Nitetime Cold and Flu ReliefCapsule, liquid filledOralCare One (American Sales Company)2012-08-01Not applicableUs
Nitetime Cold Flu ReliefCapsule, liquid filledOralMeijer2014-10-30Not applicableUs
Nitetime Cold MedicineLiquidOralIvc Industries, Hall Division1997-11-241998-07-17Canada
Nitetime Cold Medicine LiqLiquidOralJamp Pharma Corporation1992-12-31Not applicableCanada
Nitetime Cold Medicine Original and CherryLiquidOralWestcan Pharmaceuticals Ltd.Not applicableNot applicableCanada
Nitetime Cold Plus Flu ReleifCapsule, liquid filledOralDolgencorp, Inc. (Dollar General & Rexall)2014-10-30Not applicableUs
Nitetime Cold/flu, Multi-symptom ReliefCapsule, liquid filledOralWalmart Stores2016-03-09Not applicableUs
Nitetime CoughSolutionOralKroger2002-11-20Not applicableUs
Nitetime Cough Daytime CoughKitMeijer Distribution1992-01-10Not applicableUs
Nitetime DLiquidOralMeijer Distribution1994-03-29Not applicableUs
Nitetime D Multi Symptom Cold Flu ReliefLiquidOralMeijer Distribution1994-02-01Not applicableUs
Nitetime Daytime Cold and FluKitMeijer Distribution2013-12-30Not applicableUs
Nitetime Daytime Severe Cold and FluKitKroger2014-09-24Not applicableUs
Nitetime Multi-symptom Cold/flu ReliefCapsule, liquid filledOralGreenbrier International, Inc.2013-01-04Not applicableUs
Nitetime Severe Cold and FluSolutionOralKroger2014-08-13Not applicableUs
Nitetime Severe Cold and Flu ReliefSolutionOralWestern Family Foods2014-09-26Not applicableUs
Nitetime SinusCapsule, liquid filledOralMeijer2010-09-14Not applicableUs
Nitetime Sinus ReliefCapsule, liquid filledOralTopcare (Topco Associates Llc)2012-09-01Not applicableUs
Nyquil Cold and FluCapsule, liquid filledOralLil' Drug Store Products, Inc.2010-09-16Not applicableUs
Nyquil LiquicapsCapsuleOralProcter And Gamble1993-12-312005-07-28Canada
Nyquil SevereTabletOralNavajo Manuracturing Company2016-09-21Not applicableUs
Nyquil Severe Cold and FluTablet, coatedOralJc World Bell Wholesale Co., Inc.2016-05-26Not applicableUs
Nyquil Sinus LiquicapsCapsuleOralProcter And Gamble2006-06-11Not applicableCanada
Original Night-time Multi-symptom Cold/flu ReliefLiquidOralDiscount Drug Mart2014-10-21Not applicableUs
P.M. Cold Relief FormulaCapsuleOralIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
PMS-doxylamine-pyridoxineTablet, delayed releaseOralPharmascience Inc2017-07-10Not applicableCanada
Poly Hist ForteTabletOralPoly Pharmaceuticals2013-10-01Not applicableUs
Preferred Plus Severe Nite TimeSolutionOralKinray2014-07-17Not applicableUs
Preferred Plus Severe Sinus CongestionCapsule, liquid filledOralKinray2015-02-16Not applicableUs
Publix Cherry Flavor NitetimeLiquidOralPublix Supermarkets, Inc.2009-07-09Not applicableUs
Quality Choice Nighttime Cold and FluCapsule, liquid filledOralQuality Choice (Chain Drug Marketing Association, Inc.)2012-11-29Not applicableUs
Ratio-calmydoneSyrupOralTeva1981-12-312017-04-04Canada
Regular Strength Sinus MedicationTabletOralVita Health Products Inc2004-12-042011-07-20Canada
Rexall Daytime Nighttime Cold and FluKitDolgencorp2012-09-14Not applicableUs
Rexall Daytime Nighttime Cold FluKitDolgencorp2014-05-25Not applicableUs
Rexall Night Time Cold and FluLiquidOralDolgencorp2010-08-10Not applicableUs
Robitussin Complete NighttimeCapsuleOralPfizer Laboratories Div Pfizer Inc.Not applicableNot applicableCanada
Robitussin Maximum Strength Nighttime Cough DMLiquidOralRichmond Division of Wyeth2013-03-01Not applicableUs
Robitussin Peak Cold Nighttime Cold Plus FluCapsule, liquid filledOralRichmond Division of Wyeth2012-04-15Not applicableUs
Rx Act Cough and Sore ThroatLiquidOralH.E.B.2006-07-04Not applicableUs
Rx Act Nighttime Cold Flu Relief Multi SymptomCapsule, liquid filledOralH.E.B.2011-06-10Not applicableUs
Safetussin PMLiquidOralKramer Laboratories2010-12-01Not applicableUs
Safeway Nighttime Cold and FluCapsule, liquid filledOralSafeway2012-11-29Not applicableUs
Sanaflu Night-time Xtreme Multi-symptom Cold/flu Relief Cherry FlavorSyrupOralGrandall Distributing Co., Inc.2016-03-01Not applicableUs
Sanatos NightLiquidOralPharmalab Enterprises Inc.2010-02-04Not applicableUs
Sever Daytime Cold and Flu and Sever Nighttime Cold and FluKitKmart Corporation2017-07-12Not applicableUs
Severe Cold and FluTablet, film coatedOralHyvee2015-09-08Not applicableUs
Severe Cold and Flu Daytime/nighttimeKitTarget Corporation.2015-08-01Not applicableUs
Severe Cold and Flu Night TimeSolutionOralHyvee2014-01-12Not applicableUs
Severe Cold and Flu NighttimeTablet, film coatedOralTarget Corporation.2015-08-01Not applicableUs
Severe Cold and Flu Nighttime DaytimeKitHyvee2014-05-19Not applicableUs
Severe Cold and Flu ReliefSolutionOralRite Aid2014-06-27Not applicableUs
Severe Cold and Flu Relief NighttimeTablet, film coatedOralRite Aid2015-07-15Not applicableUs
Severe Cold Plus Flu Daytime NighttimeKitCvs Health2017-07-14Not applicableUs
Severe NighttimeSolutionOralCvs Health2013-12-27Not applicableUs
Severe Nighttime Cold and FluCapsule, gelatin coatedOralWalgreens2016-05-01Not applicableUs
Severe Nighttime Severe DaytimeKitCvs Health2013-12-27Not applicableUs
Severe Sinus CongestionCapsule, liquid filledOralKroger2014-05-14Not applicableUs
Severe Sinus Congestion Allergy and Cough FormulaCapsule, liquid filledOralPura Cap Pharmaceutical Llc.2016-06-29Not applicableUs
Shoprite Ni CalmCapsule, gelatin coatedOralWakfern Food Corporation2014-05-12Not applicableUs
Shoprite Ni Calm CoughSolutionOralWakfern Food Corporation2013-06-27Not applicableUs
Signature Care Nighttime Severe Cold and Flu ReliefSolutionOralSafeway2016-01-24Not applicableUs
Simply Right Night TimeLiquidOralSam's West, Inc2006-08-30Not applicableUs
SinexCapsule, liquid filledOralProcter And Gamble2016-07-29Not applicableUs
Sinex Nighttime SinusCapsuleOralProcter And GambleNot applicableNot applicableCanada
Sinus Day/night Extra StrengthKit; TabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Sinus MedicationTabletOralVita Health Products Inc2003-03-07Not applicableCanada
Sinus Medication Day & NightKit; TabletOralVita Health Products Inc2012-05-05Not applicableCanada
Sinus Medication Extra Strength Night TimeTabletOralPharmascience Inc2002-12-082016-10-28Canada
Sinus Medication Night TabletsTabletOralPharmetics (2011) Inc.2005-10-17Not applicableCanada
Sinus NighttimeCapsule, liquid filledOralCare One (American Sales Company)2012-10-31Not applicableUs
Sinus Relief Daytime NighttimeKitWalgreen2005-07-21Not applicableUs
Smart Sense Daytime Nighttime Cold and FluKitKmart Corporation2013-04-15Not applicableUs
Smart Sense NighttimeLiquidOralKmart Corporation2009-07-09Not applicableUs
Smart Sense Nighttime Cold and FluTablet, film coatedOralKmart Corporation2015-08-06Not applicableUs
Smart Sense Nighttime Cold and Flu Relief Multi SymptomLiquidOralKmart Corporation2011-06-21Not applicableUs
Smart Sense Nighttime CoughLiquidOralKmart Corporation2010-12-03Not applicableUs
Smart Sense Nighttime DaytimeKitKmart Corporation2013-08-23Not applicableUs
Smart Sense Severe Cold and Flu NighttimeSolutionOralKmart Corporation2013-11-22Not applicableUs
Smith Bros Night Time Cough and CongestionPowder, for solutionOralUniversal Holdings I Llc2014-07-092015-12-29Us
Sound Body Cold and Flu ReliefSolutionOralBig Lots Stores, Inc.2015-03-04Not applicableUs
Sunmark Nite TimeSolutionOralMc Kesson2011-11-21Not applicableUs
Sunmark Nite Time Cold and FluLiquidOralMc Kesson2006-04-28Not applicableUs
Sunmark Nite Time CoughLiquidOralMc Kesson2003-07-03Not applicableUs
Sunmark Nite Time D Cold and FluLiquidOralMc Kesson2003-08-24Not applicableUs
Target Cold/flu ReliefLiquidOralTarget Corporation.2009-07-09Not applicableUs
Topcare Clear TimeCapsule, liquid filledOralTopco Associates2015-02-152016-10-29Us
Topcare Cold and CoughLiquidOralTopco Associates2006-03-09Not applicableUs
Topcare Cold MaxSolutionOralTopco Associates2016-04-12Not applicableUs
Topcare Cough and Sore ThroatLiquidOralTopco Associates2006-03-09Not applicableUs
Topcare Day Time Nite TimeKitTopco Associates2007-11-272017-02-04Us
Topcare Day Time Nite Time Cold and FluKitTopco Associates2015-09-12Not applicableUs
Topcare Day Time Nite Time Cold and Flu ReliefKitTopco Associates2012-10-15Not applicableUs
Topcare Daytime Nighttime Clear TimeKitTopco Associates2015-02-042016-10-19Us
Topcare Nite TimeCapsule, liquid filledOralTopco Associates2006-06-12Not applicableUs
Topcare Nite Time Cold and FluLiquidOralTopco Associates2006-06-12Not applicableUs
Topcare Nite Time Cold and Flu ReliefSolutionOralTopco Associates2012-07-17Not applicableUs
Topcare Nite Time Cold and Flu Relief Multi Symptom ReliefCapsule, liquid filledOralTopco Associates2006-06-12Not applicableUs
Topcare Nite Time CoughSolutionOralTopco Associates2002-12-10Not applicableUs
Topcare Nite Time DLiquidOralTopco Associates1989-12-15Not applicableUs
Topcare Nite Time Day Time Cold and FluKitTopco Associates2014-04-29Not applicableUs
Topcare Nite Time Day Time Cold and Flu ReliefKitTopco Associates2011-12-15Not applicableUs
Topcare Nite Time Multi Symptom ReliefLiquidOralTopco Associates2009-07-28Not applicableUs
Topcare Pain Relief Cold NightttimeSolutionOralTopco Associates2016-01-31Not applicableUs
Topcare Severe Sinus CongestionCapsule, liquid filledOralTopco Associates2014-06-222016-10-29Us
Topcare Tussin DM Nighttime CoughSolutionOralTopco Associates2016-07-17Not applicableUs
Tussin DM Cough Nighttime Maximum StrengthLiquidOralP & L Development, LLC2016-09-30Not applicableUs
Tussin DM Maximum StrengthLiquidOralCvs Health2014-05-31Not applicableUs
Tussin Nighttime Cough ControlSolutionOralHyvee2016-08-12Not applicableUs
Tussin Nighttime Cough DM Maximum StrengthLiquidOralFamily Dollar (FAMILY WELLNESS)2016-07-31Not applicableUs
Tylenol Cold & Flu NighttimeLiquidOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2005-08-222008-08-07Canada
Tylenol Cold and Flu NighttimeLiquidOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2007-01-122016-01-12Canada
Tylenol Cold Max NightSolutionOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2015-04-13Not applicableUs
Tylenol Cold Multi-symptomSolutionOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2006-07-012017-06-22Us
Tylenol Cold Plus Flu Severe and Tylenol Cold MaxKitJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2016-10-03Not applicableUs
Up and Up Cold and Flu ReliefLiquidOralTarget Corporation.2011-09-23Not applicableUs
Up and Up Cold and Flu Relief Multi Symptom Day and Night Combo PackKitTarget Corporation.2012-10-11Not applicableUs
Up and Up Cold Flu ReliefCapsule, gelatin coatedOralTarget Corporation.2014-02-05Not applicableUs
Up and Up Cold Flu Relief Day NightKitTarget Corporation.2014-08-18Not applicableUs
Up and Up Cold Flu Relief Multi Symptom NightLiquidOralTarget Corporation.2009-06-11Not applicableUs
Up and Up Daytime Nighttime Cold and FluKitTarget Corporation.2014-07-30Not applicableUs
Up and Up Nighttime Cold and FluCapsule, liquid filledOralTarget Corporation.2015-04-15Not applicableUs
Up and Up Nighttime Cough ControlSolutionOralTarget Corporation.2016-07-11Not applicableUs
Up and Up Nighttime Daytime Cold and FluKitTarget Corporation.2015-05-07Not applicableUs
Up and Up Severe Cold and FluKitTarget Corporation.2016-07-19Not applicableUs
Up and Up Severe Cold and Flu NighttimeSolutionOralTarget Corporation.2015-08-03Not applicableUs
Vicks Dayquil and Vicks Nyquil Cherry Cold and FluKitOralProcter And Gamble2013-07-01Not applicableUs
Vicks Dayquil and Vicks Nyquil Cold and FluKitOralProcter And Gamble2013-08-01Not applicableUs
Vicks Dayquil and Vicks Nyquil Cold and Flu Multi-symptom Relief/cold and Flu Nighttime ReliefKitProcter And Gamble2014-03-21Not applicableUs
Vicks Dayquil and Vicks Nyquil Severe Cold and FluKitProcter And Gamble2014-07-31Not applicableUs
Vicks Dayquil Tropical and Vicks Nyquil Cherry CoughKitOralProcter And Gamble2013-08-01Not applicableUs
Vicks Nyquil Adult Nighttime Colds MedicineLiquidOralProcter And Gamble1990-12-312006-07-07Canada
Vicks Nyquil Cold & Flu Nighttime ReliefLiquidOralProcter And Gamble2012-07-09Not applicableCanada
Vicks Nyquil Cold and FluCapsule, liquid filledOralMechanical Servants, Llc2010-01-01Not applicableUs
Vicks Nyquil Cold and Flu Nighttime ReliefCapsule, liquid filledOralProcter And Gamble2011-06-09Not applicableUs
Vicks Nyquil Cold and Flu Nighttime Relief and Vicks Childrens Nyquil Cold and CoughKitProcter And Gamble2012-07-232016-11-01Us
Vicks Nyquil Complete Cold & FluLiquidOralProcter And Gamble2014-08-15Not applicableCanada
Vicks Nyquil Complete Cold & Flu CapletsTabletOralProcter And Gamble2015-07-08Not applicableCanada
Vicks Nyquil CoughLiquidOralProcter And Gamble2011-06-22Not applicableUs
Vicks Nyquil D Cold and Flu Nighttime ReliefLiquidOralProcter And Gamble2012-09-172016-11-01Us
Vicks Nyquil Hbp Cold and FluLiquidOralProcter And Gamble2017-02-01Not applicableUs
Vicks Nyquil LiquicapsCapsuleOralProcter And Gamble2004-03-012006-07-25Canada
Vicks Nyquil Liquicaps Cold & Flu Multi-symptom ReliefCapsuleOralProcter And Gamble2006-06-26Not applicableCanada
Vicks Nyquil Severe Cold and FluSolutionOralProcter And Gamble2014-07-21Not applicableUs
Vicks Nyquil Sinus LiquicapsCapsuleOralProcter And Gamble2005-07-012006-07-28Canada
Vicks Qlearquil Daytime Sinus and Congestion and Nighttime Sinus and CongestionKitProcter And Gamble2014-07-212018-03-05Us
Vicks Qlearquil Nighttime Sinus and CongestionCapsule, liquid filledOralProcter And Gamble2014-03-01Not applicableUs
Walgreen Nighttime Cold and Flu ReliefLiquidOralWalgreen2009-07-09Not applicableUs
Waltussin DM MaxKitWalgreen2016-07-10Not applicableUs
Welby Nighttime Cold and FluSolutionOralAldi, Inc2017-07-14Not applicableUs
ZicamLiquidOralMatrixx Initiatives, Inc.2007-07-16Not applicableUs
Zicam Multi-symptom Cold & Flu NighttimeLiquidOralZicam Llc2008-10-302009-11-20Canada
Categories
UNII95QB77JKPL
CAS number469-21-6
WeightAverage: 270.3694
Monoisotopic: 270.173213336
Chemical FormulaC17H22N2O
InChI KeyHCFDWZZGGLSKEP-UHFFFAOYSA-N
InChI
InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3
IUPAC Name
dimethyl({2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethyl})amine
SMILES
CN(C)CCOC(C)(C1=CC=CC=C1)C1=CC=CC=N1
Pharmacology
Indication

Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.

Structured Indications
Pharmacodynamics

Doxylamine is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power far superior to virtually every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most powerful over-the-counter sedative available in the United States, and more sedating than many prescription hypnotics. In a study, it was found to be superior to even the barbiturate, phenobarbital for use as a sedative. Doxylamine is also a potent anticholinergic.

Mechanism of action

Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.

TargetKindPharmacological actionActionsOrganismUniProt ID
Histamine H1 receptorProteinyes
antagonist
HumanP35367 details
Muscarinic acetylcholine receptor M1Proteinunknown
antagonist
HumanP11229 details
Nuclear receptor subfamily 1 group I member 3ProteinunknownNot AvailableHumanQ14994 details
Related Articles
Absorption

Readily absorbed via the gastrointestinal tract.

Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic.

Route of eliminationNot Available
Half life

10 hours

ClearanceNot Available
Toxicity

Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.

Affected organisms
  • Humans and other mammals
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Doxylamine.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Doxylamine.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Doxylamine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Doxylamine.Experimental, Illicit
7-NitroindazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of 7-Nitroindazole.Experimental
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the anticholinergic activities of Doxylamine.Experimental
AcepromazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.Approved, Vet Approved
AceprometazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.Approved
AdipiplonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of adipiplon.Investigational
AgomelatineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.Approved, Investigational
AlfaxaloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alfaxalone.Vet Approved
AlfentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.Approved, Illicit
AllopregnanoloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sage 547.Investigational
AlphacetylmethadolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alphacetylmethadol.Experimental, Illicit
AlprazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.Approved, Illicit, Investigational
AmisulprideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amisulpride.Approved, Investigational
AmitriptylineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.Approved
AmobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.Approved, Illicit
AmoxapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.Approved
AmperozideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amperozide.Experimental
AmphetamineAmphetamine may decrease the sedative activities of Doxylamine.Approved, Illicit
AripiprazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.Approved, Investigational
ArticaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Articaine.Approved
AsenapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Asenapine.Approved
AzelastineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Baclofen.Approved
BarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Barbital.Illicit
BenmoxinBenmoxin may increase the anticholinergic activities of Doxylamine.Withdrawn
BenperidolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Benperidol.Investigational
BenzocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.Approved
BenzphetamineBenzphetamine may decrease the sedative activities of Doxylamine.Approved, Illicit
Benzyl alcoholDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved
Benzylpenicilloyl PolylysineDoxylamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Doxylamine.Approved
BrexpiprazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved
BromazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.Approved, Illicit
BrompheniramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.Approved
BrotizolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved, Withdrawn
BupivacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved, Investigational
BuprenorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Buspirone.Approved, Investigational
ButabarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.Approved, Illicit
ButalbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butalbital.Approved, Illicit
ButethalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butethal.Approved, Illicit
ButorphanolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.Approved, Illicit, Vet Approved
CarbamazepineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.Approved, Investigational
CarbinoxamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.Approved
CarfentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Illicit, Vet Approved
CarisoprodolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.Approved
CaroxazoneCaroxazone may increase the anticholinergic activities of Doxylamine.Withdrawn
CetirizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.Approved
Chloral hydrateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved, Illicit
ChlormezanoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.Approved, Withdrawn
ChloroprocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chloroprocaine.Approved
ChlorphenamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved
ChlorphentermineChlorphentermine may decrease the sedative activities of Doxylamine.Illicit, Withdrawn
ChlorpromazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.Approved, Vet Approved
ChlorprothixeneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved
CinchocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cinchocaine.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Doxylamine is combined with Citalopram.Approved
ClemastineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved
ClidiniumDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clidinium.Approved
ClobazamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Illicit
ClomipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.Approved, Vet Approved
ClonazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.Approved, Illicit
ClonidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clonidine.Approved
ClorazepateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.Approved, Illicit
ClozapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clozapine.Approved
CocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cocaine.Approved, Illicit
CodeineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Codeine.Approved, Illicit
CyclizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.Approved
CyclobenzaprineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.Approved
CyproheptadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.Approved
DantroleneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.Approved
DapiprazoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Dapoxetine.Investigational
DeramciclaneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of deramciclane.Investigational
DesfluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved
DesipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.Approved
DesloratadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Desvenlafaxine.Approved
DexbrompheniramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.Approved
DexmedetomidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.Approved, Vet Approved
DextroamphetamineDextroamphetamine may decrease the sedative activities of Doxylamine.Approved, Illicit
DextromoramideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dextromoramide.Experimental, Illicit
DextropropoxypheneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved
DiazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Diazepam.Approved, Illicit, Vet Approved
DiethylpropionDiethylpropion may decrease the sedative activities of Doxylamine.Approved, Illicit
DifenoxinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.Approved, Illicit
DihydrocodeineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dihydrocodeine.Approved, Illicit
DihydroetorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dihydroetorphine.Experimental, Illicit
DihydromorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.Experimental, Illicit
DimenhydrinateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.Approved
DiphenhydramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved
DiphenoxylateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Diphenoxylate.Approved, Illicit
DoxepinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.Approved
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved, Vet Approved
DrotebanolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Drotebanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Duloxetine.Approved
DyclonineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.Approved
EcgonineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ecgonine.Experimental, Illicit
EcopipamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ecopipam.Investigational
EfavirenzDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.Approved, Investigational
EltanoloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pregnanolone.Investigational
EnfluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Enflurane.Approved, Vet Approved
EntacaponeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Entacapone.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Doxylamine is combined with Escitalopram.Approved, Investigational
EstazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Estazolam.Approved, Illicit
EszopicloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.Approved
EthanolEthanol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved
EthchlorvynolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethchlorvynol.Approved, Illicit, Withdrawn
EthosuximideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.Approved
EthotoinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.Approved
Ethyl carbamateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethyl carbamate.Withdrawn
Ethyl loflazepateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethyl loflazepate.Approved, Illicit
EthylmorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.Approved, Illicit
EtidocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.Approved
EtifoxineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Withdrawn
EtizolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etizolam.Approved
EtomidateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etomidate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Doxylamine is combined with Etoperidone.Approved
EtorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Illicit, Vet Approved
EzogabineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.Approved
FelbamateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Felbamate.Approved
FencamfamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fencamfamine.Approved, Illicit, Withdrawn
FentanylDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved
FlibanserinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.Approved
FludiazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fludiazepam.Approved, Illicit
FlunarizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.Approved
FlunitrazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flunitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Fluoxetine.Approved, Vet Approved
FlupentixolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.Approved, Withdrawn
FluphenazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.Approved
FlurazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.Approved, Illicit
FluspirileneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.Approved
Fluticasone propionateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved
FluvoxamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluvoxamine.Approved, Investigational
FosphenytoinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.Approved
FospropofolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.Approved, Illicit
FurazolidoneFurazolidone may increase the anticholinergic activities of Doxylamine.Approved, Vet Approved
GabapentinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.Approved, Investigational
Gabapentin EnacarbilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Gamma Hydroxybutyric Acid.Approved, Illicit
GepironeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Investigational
GlutethimideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Illicit
GuanfacineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.Approved, Investigational
HalazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.Approved, Illicit, Withdrawn
HaloperidolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.Approved
HalothaneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Halothane.Approved, Vet Approved
HeroinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved, Illicit
HexobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Doxylamine.Approved, Investigational
HydracarbazineHydracarbazine may increase the anticholinergic activities of Doxylamine.Experimental
HydrocodoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.Approved, Illicit
HydroxyamphetamineHydroxyamphetamine hydrobromide may decrease the sedative activities of Doxylamine.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved
IloperidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.Approved
ImipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Indalpine.Investigational, Withdrawn
IproclozideIproclozide may increase the anticholinergic activities of Doxylamine.Withdrawn
IproniazidIproniazid may increase the anticholinergic activities of Doxylamine.Withdrawn
IsocarboxazidIsocarboxazid may increase the anticholinergic activities of Doxylamine.Approved
IsofluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.Approved, Vet Approved
KetamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketamine.Approved, Vet Approved
KetazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.Approved
KetobemidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.Approved
LamotrigineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.Approved, Investigational
LevetiracetamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.Approved, Investigational
LevobupivacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.Approved
LevocabastineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.Approved
LevocetirizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.Approved
LevodopaDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levodopa.Approved
Levomethadyl AcetateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levomethadyl Acetate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Doxylamine is combined with Levomilnacipran.Approved
LevorphanolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.Approved
LidocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Doxylamine.Approved, Investigational
LithiumDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lithium.Approved
LofentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.Illicit
LoratadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved
LorazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved
LoxapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Loxapine.Approved
LurasidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved, Vet Approved
MaprotilineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.Approved
MebanazineMebanazine may increase the anticholinergic activities of Doxylamine.Withdrawn
MeclizineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved
MelatoninDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Melperone.Approved
MephedroneMephedrone may decrease the sedative activities of Doxylamine.Investigational
MephentermineMephentermine may decrease the sedative activities of Doxylamine.Approved
MepivacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine.Approved, Vet Approved
MeprobamateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.Approved, Illicit
MesoridazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Mesoridazine.Approved
MetaxaloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.Approved
MethadoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methadone.Approved
Methadyl AcetateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved, Illicit
MethamphetamineMethamphetamine may decrease the sedative activities of Doxylamine.Approved, Illicit
MethapyrileneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methapyrilene.Withdrawn
MethaqualoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Illicit, Withdrawn
MethocarbamolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.Approved, Vet Approved
MethohexitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methohexital.Approved
MethotrimeprazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methoxyflurane.Approved, Vet Approved
MethsuximideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.Approved
MethylecgonineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of ECGONINE METHYL ESTER.Experimental
Methylene blueMethylene blue may increase the anticholinergic activities of Doxylamine.Investigational
MethylphenobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methylphenobarbital.Approved
MetyrosineDoxylamine may increase the sedative activities of Metyrosine.Approved
MidazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Midazolam.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Doxylamine is combined with Milnacipran.Approved
MinaprineMinaprine may increase the anticholinergic activities of Doxylamine.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved, Investigational
MirtazapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MMDAMMDA may decrease the sedative activities of Doxylamine.Experimental, Illicit
MoclobemideMoclobemide may increase the anticholinergic activities of Doxylamine.Approved
MolindoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Molindone.Approved
MorphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Morphine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved, Investigational
NalbuphineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Doxylamine is combined with Nefazodone.Approved, Withdrawn
NialamideNialamide may increase the anticholinergic activities of Doxylamine.Withdrawn
NitrazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved
Nitrous oxideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Vet Approved
NorfluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of 1,1,1,2 Tetrafluoroethane.Investigational
NormethadoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Normethadone.Approved, Illicit
NortriptylineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.Approved
OctamoxinOctamoxin may increase the anticholinergic activities of Doxylamine.Withdrawn
OlanzapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.Approved, Investigational
OlopatadineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.Approved
OndansetronDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ondansetron.Approved
OpiumDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Opium.Approved, Illicit
OrphenadrineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Osanetant.Investigational
OxazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.Approved
OxethazaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.Investigational
OxprenololDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxprenolol.Approved
OxybuprocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.Approved
OxycodoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.Approved, Illicit, Investigational
OxymorphoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.Approved, Investigational, Vet Approved
PaliperidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.Approved
ParaldehydeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PargylinePargyline may increase the anticholinergic activities of Doxylamine.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Paroxetine.Approved, Investigational
PentazocineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.Approved, Vet Approved
PentobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved
PerazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Perazine.Investigational
PerospironeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Perospirone.Approved
PerphenazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.Approved
PethidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pethidine.Approved
PhenelzinePhenelzine may increase the anticholinergic activities of Doxylamine.Approved
PheniprazinePheniprazine may increase the anticholinergic activities of Doxylamine.Withdrawn
PhenobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.Approved
PhenoxypropazinePhenoxypropazine may increase the anticholinergic activities of Doxylamine.Withdrawn
PhenterminePhentermine may decrease the sedative activities of Doxylamine.Approved, Illicit
PhenytoinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.Approved, Vet Approved
PimozideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pimozide.Approved
PipamperoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.Approved
PipotiazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.Approved
PiritramideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Piritramide.Investigational
PirlindolePirlindole may increase the anticholinergic activities of Doxylamine.Approved
PivhydrazinePivhydrazine may increase the anticholinergic activities of Doxylamine.Withdrawn
PomalidomideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.Approved
PramipexoleDoxylamine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.Approved
PrazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Prazepam.Approved, Illicit
PregabalinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Illicit, Investigational
PrilocaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.Approved
PrimidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved, Vet Approved
ProcaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Procaine.Approved, Investigational, Vet Approved
ProchlorperazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.Approved, Vet Approved
PromazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Promazine.Approved, Vet Approved
PromethazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Promethazine.Approved
ProparacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved, Vet Approved
PropofolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Propofol.Approved, Investigational, Vet Approved
PropoxycaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved
ProtriptylineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.Approved
PseudoephedrinePseudoephedrine may decrease the sedative activities of Doxylamine.Approved
QuazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Quazepam.Approved, Illicit
QuetiapineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.Approved
RacloprideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Raclopride.Investigational
RamelteonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.Approved, Investigational
RasagilineRasagiline may increase the anticholinergic activities of Doxylamine.Approved
RemifentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.Approved
RemoxiprideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.Approved, Withdrawn
ReserpineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Reserpine.Approved
RisperidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Risperidone.Approved, Investigational
RitanserinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ritanserin.Investigational
RitobegronRitobegron may decrease the sedative activities of Doxylamine.Investigational
RopiniroleDoxylamine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.Approved
RotigotineDoxylamine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Doxylamine.Approved
SafrazineSafrazine may increase the anticholinergic activities of Doxylamine.Withdrawn
ScopolamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.Approved
SecobarbitalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.Approved, Vet Approved
SelegilineSelegiline may increase the anticholinergic activities of Doxylamine.Approved, Investigational, Vet Approved
SepranoloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Uc1010.Investigational
SertindoleDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Sertraline.Approved
SevofluraneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved
StiripentolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved
SufentanilDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.Approved, Investigational
SulpirideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.Approved
SuvorexantDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved
TasimelteonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.Approved
TemazepamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Temazepam.Approved
TetrabenazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetrabenazine.Approved
TetracaineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetracaine.Approved, Vet Approved
TetrodotoxinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin.Investigational
ThalidomideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thiamylal.Approved, Vet Approved
ThiopentalDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thiopental.Approved, Vet Approved
ThioridazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.Withdrawn
ThiothixeneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.Approved
TiagabineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.Approved
TiaprideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tiapride.Approved, Investigational
TizanidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.Approved
TolcaponeDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.Approved, Withdrawn
ToloxatoneToloxatone may increase the anticholinergic activities of Doxylamine.Approved
TopiramateDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Topiramate.Approved
TramadolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.Approved, Investigational
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the anticholinergic activities of Doxylamine.Experimental
TranylcypromineTranylcypromine may increase the anticholinergic activities of Doxylamine.Approved
TrazodoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Trazodone.Approved, Investigational
TriazolamDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Triazolam.Approved
TrifluoperazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.Approved
TriflupromazineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Triflupromazine.Approved, Vet Approved
TrimipramineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved
TriprolidineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.Approved
Valproic AcidDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Valproic Acid.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Venlafaxine.Approved
VigabatrinDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.Approved
VortioxetineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.Approved
ZaleplonDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.Approved, Illicit, Investigational
ZiconotideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Zimelidine.Withdrawn
ZiprasidoneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.Approved
ZolpidemDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.Approved, Investigational
ZopicloneDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.Approved
ZotepineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zotepine.Approved
ZuclopenthixolDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesR06AA59 — Doxylamine, combinationsR06AA09 — Doxylamine
AHFS Codes
  • 04:04.04
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableAllergic Rhinitis (AR) / Upper Respiratory Infections1
3CompletedPreventionHyperemesis Gravidarum / Pregnancy1
3CompletedTreatmentNausea and Vomiting of Pregnancy1
4RecruitingTreatmentMorning Sickness1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Capsule, gelatin coatedOral
Kit
Tablet, effervescentOral
Powder, for solutionOral
Capsule; kitOral
CapsuleOral
KitOral
Tablet, delayed releaseOral
SolutionOral
TabletOral25 mg/1
SyrupOral
Tablet, coatedOral
TabletOral
LiquidOral
Capsule, liquid filledOral
SyrupOral9.75 mg/5mL
Tablet, film coatedOral
Kit; tabletOral
TabletOral25 mg
Prices
Unit descriptionCostUnit
Doxylamine succinate powder1.5USD g
Unisom sleep aid tablet0.34USD tablet
Sleep aid 25 mg tablet0.15USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6340695 No2001-06-212021-06-21Us
US7560122 No1999-01-252019-01-25Us
US9526703 No2013-02-182033-02-18Us
US9375404 No2013-02-182033-02-18Us
US9089489 No2013-02-182033-02-18Us
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point (°C)< 25 °CPhysProp
boiling point (°C)139 °C at 5.00E-01 mm HgPhysProp
water solubility1 g/ml (succinate salt)Not Available
logP2.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.541 mg/mLALOGPS
logP2.9ALOGPS
logP2.96ChemAxon
logS-2.7ALOGPS
pKa (Strongest Basic)8.87ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area25.36 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity82.24 m3·mol-1ChemAxon
Polarizability31.09 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9505
Blood Brain Barrier+0.9491
Caco-2 permeable+0.746
P-glycoprotein substrateSubstrate0.7449
P-glycoprotein inhibitor INon-inhibitor0.5123
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterInhibitor0.7507
CYP450 2C9 substrateNon-substrate0.8153
CYP450 2D6 substrateNon-substrate0.5432
CYP450 3A4 substrateSubstrate0.6801
CYP450 1A2 substrateNon-inhibitor0.9092
CYP450 2C9 inhibitorNon-inhibitor0.8957
CYP450 2D6 inhibitorInhibitor0.8361
CYP450 2C19 inhibitorNon-inhibitor0.8764
CYP450 3A4 inhibitorNon-inhibitor0.6894
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.736
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9183
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.9218 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8765
hERG inhibition (predictor II)Inhibitor0.5398
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0040-0956300000-af11cf85a674e7db3735View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-001i-0910000000-b3cb895f045d519f2bf3View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-00kb-5597500000-8495062a84b32e776f33View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-001i-1920000000-07b98b36c7ef5d9ad048View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-001i-0900000000-1ae1143763892a7aac22View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-001i-0900000000-460d58a5bb6a5eb5f55bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-0159-0900000000-34dc5c06413efae437daView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-014i-0900000000-8a5f15b863b7129c1288View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-014i-0900000000-072ffba5139b7324d27aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - , positivesplash10-00lr-0900000000-fdf3fc57eff19bfe8fd8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-qTof , PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0ab9-9200000000-5a71de62862f9881c2a1View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzylethers. These are aromatic ethers with the general formula ROCR' (R = alkyl, aryl; R'=benzene).
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzylethers
Direct ParentBenzylethers
Alternative ParentsPyridines and derivatives / Heteroaromatic compounds / Trialkylamines / Dialkyl ethers / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
SubstituentsBenzylether / Pyridine / Heteroaromatic compound / Tertiary amine / Tertiary aliphatic amine / Azacycle / Organoheterocyclic compound / Ether / Dialkyl ether / Amine
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptorstertiary amine, pyridines (CHEBI:51380 )

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Uniprot Name:
Histamine H1 receptor
Molecular Weight:
55783.61 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Phosphatidylinositol phospholipase c activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM1
Uniprot ID:
P11229
Uniprot Name:
Muscarinic acetylcholine receptor M1
Molecular Weight:
51420.375 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Gene Name:
NR1I3
Uniprot ID:
Q14994
Uniprot Name:
Nuclear receptor subfamily 1 group I member 3
Molecular Weight:
39942.145 Da
References
  1. Dring AM, Anderson LE, Qamar S, Stoner MA: Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands. Chem Biol Interact. 2010 Dec 5;188(3):512-25. doi: 10.1016/j.cbi.2010.09.018. Epub 2010 Oct 20. [PubMed:20869355 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Not Available
Gene Name:
CYP2B
Uniprot ID:
Q14097
Uniprot Name:
CYP2B protein
Molecular Weight:
43147.81 Da
References
  1. Bookstaff RC, Murphy VA, Skare JA, Minnema D, Sanzgiri U, Parkinson A: Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice. Toxicol Appl Pharmacol. 1996 Dec;141(2):584-94. [PubMed:8975784 ]
Drug created on June 13, 2005 07:24 / Updated on August 08, 2017 11:03