Doxylamine - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (3)Enzymes (1)

Targets (3)Enzymes (1)Biointeractions (3)

Identification

Name

Doxylamine

Accession Number

DB00366 (APRD00937)

Type

Small Molecule

Groups

Approved, Vet Approved

Description

Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. [PubChem]

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine

2-Dimethylaminoethoxyphenylmethyl-2-picoline

Dossilamina

Doxilamina

Doxilminio

Doxylaminum

N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine

Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether

External IDs

Not Available

Product Ingredients

Ingredient	UNII	CAS	InChI Key	Details
Doxylamine succinate	V9BI9B5YI2	562-10-7	KBAUFVUYFNWQFM-UHFFFAOYSA-N	Details

Product Images

Approved Prescription Products

Not Available

Approved Generic Prescription Products

Not Available

Approved Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
7 Select Sleep Aid	Tablet	25 mg/1	Oral	7 Eleven	2014-08-05	Not applicable	US
Care One Sleep Aid	Tablet	25 mg/1	Oral	American Sales Company	2004-06-29	Not applicable	US
CareOne Nighttime Sleep Aid	Tablet	25 mg/1	Oral	American Sales Company	2016-05-06	Not applicable	US
Equaline Sleep Aid	Tablet	25 mg/1	Oral	Supervalu	2004-08-10	Not applicable	US
Good Neighbor Pharmacy Sleep Aid	Tablet	25 mg/1	Oral	Amerisource Bergen	1997-06-26	Not applicable	US
Good sense sleep aid	Tablet	25 mg/1	Oral	L. Perrigo Company	1997-04-14	Not applicable	US
Harris Teeter Sleep Aid	Tablet	25 mg/1	Oral	Harris Teeter	2015-11-21	Not applicable	US
Health Mart Sleep Aid	Tablet	25 mg/1	Oral	Mc Kesson	2011-11-21	Not applicable	US
Healthy Accents Sleep Aid	Tablet	25 mg/1	Oral	Dza Brands,	2011-06-06	Not applicable	US
Kirkland Signature Sleep Aid	Tablet	25 mg/1	Oral	Costco Wholesale	2003-06-27	Not applicable	US
Leader sleep aid	Tablet	25 mg/1	Oral	Cardinal Health	1997-10-21	Not applicable	US
Nighttime Fast Sleep Aid	Tablet	25 mg/1	Oral	Fred's	2002-04-11	2016-02-26	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Cvs Health	1997-07-23	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Cvs Health	2002-04-11	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Kroger	2014-07-15	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Better Living Brands	2002-04-11	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Great Lakes Wholesale, Marketing, and Sales, Inc.	2002-04-11	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Hyvee	2014-12-04	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Walmart Stores	2002-04-11	Not applicable	US
Nighttime Sleepaid	Tablet	25 mg/1	Oral	Western Family Foods	1997-11-11	Not applicable	US
Sambrosa Sweet Dreams Nighttime	Syrup	9.75 mg/5mL	Oral	Sambrosa Care Inc.	2015-07-01	Not applicable	US
ShopRite Sleep-Aid	Tablet	25 mg/1	Oral	Wakfern Food Corporation	2017-05-16	Not applicable	US
Sleep aid	Tablet	25 mg/1	Oral	Hannaford Brothers Company	1997-02-07	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Rite Aid	2001-04-11	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Sunmark (Mckesson)	2002-04-11	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	H.E.B.	1998-05-06	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Army + Air Force Exchange Service	2002-04-11	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Meijer Distribution	1997-02-21	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Hyvee	1998-09-01	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Cardinal Health	2002-04-11	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Costco Wholesale	2002-04-11	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Supervalu	2002-04-11	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Fred's	2002-04-11	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Kroger	1997-05-02	Not applicable	US
Sleep Aid Nighttime	Tablet	25 mg/1	Oral	Mc Kesson (Health Mart)	2002-04-11	Not applicable	US
Sleep Aid Nighttime	Tablet	25 mg/1	Oral	Cardinal Health	2002-04-11	Not applicable	US
Sleep-Aid	Tablet	25 mg/1	Oral	H.E.B.	2002-04-11	Not applicable	US
Smart Sense Sleep Aid	Tablet	25 mg/1	Oral	Kmart Corporation	2010-12-29	Not applicable	US
Sunmark sleep aid	Tablet	25 mg/1	Oral	Mc Kesson	2003-08-15	Not applicable	US
TopCare Sleep Aid	Tablet	25 mg/1	Oral	Topco Associates	1997-01-29	Not applicable	US
Unisom SleepTabs	Tablet	25 mg/1	Oral	Chattem, Inc.	2016-01-15	Not applicable	US
Unisom SleepTabs	Tablet	25 mg/1	Oral	Chattem, Inc.	1978-10-18	Not applicable	US
Unisom-2 Tablets	Tablet	25 mg	Oral	Paladin Labs Inc	1987-12-31	Not applicable	Canada
Wal Som Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Walgreen	1999-03-05	Not applicable	US

Unapproved/Other Products

Not Available

International Brands

Not Available

Brand mixtures

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
7 Select Night Time Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	7 Eleven	2014-04-17	Not applicable	US
Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HCl	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Cvs Pharmacy,inc	2017-07-07	Not applicable	US
ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE and DOXYLAMINE SUCCINATE	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	J.P. BUSINESS ENTERPRISE	2014-12-01	Not applicable	US
Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine Hydrochloride	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Granules India Limited	2017-07-07	Not applicable	US
ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and DOXYLAMINE SUCCINATE	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Spirit Pharmaceuticals, Llc	2009-10-15	Not applicable	US
Acetaminophen,Dextromethorphan,Doxylamine	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Agile Pharmachem	2014-05-01	Not applicable	US
Acetaminophen/pseudoephedrine/dextromethorphan/doxylamine	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Apotex Corporation	Not applicable	Not applicable	Canada
Alka-Seltzer Plus Day and Night Cold and Flu Formula	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Bayer Health Care Llc.	2013-10-30	2018-08-31	US
Alka-Seltzer Plus Day and Night Multi-Symptom Cold and Flu Formula	Doxylamine Phenylephrine	Kit		Bayer Health Care Llc, Consumer Care	2012-05-30	Not applicable	US
Alka-Seltzer Plus Day and Night Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Bayer	2014-07-01	Not applicable	US
Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit	Oral	Bayer Health Care Llc.	2017-05-22	Not applicable	US
Alka-Seltzer Plus Maximum Strength Night Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc.	2017-06-19	Not applicable	US
Alka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and Night	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit	Oral	Bayer Health Care Llc.	2017-06-12	Not applicable	US
Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc.	2017-06-26	Not applicable	US
Alka-Seltzer Plus Multi-Smptom Cold and Flu Night	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc.	2016-07-01	2018-06-30	US
Alka-Seltzer Plus Multi-Symptom Cold and Flu Day and Night Liquid Gels	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit	Oral	Bayer	2016-07-15	Not applicable	US
Alka-Seltzer Plus Multi-Symptom Cold Night	Acetylsalicylic acid Dextromethorphan Doxylamine Phenylephrine	Tablet, effervescent	Oral	Bayer Health Care Llc.	2017-07-15	Not applicable	US
Alka-Seltzer Plus Night Cold and Flu Formula	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc, Consumer Care	2012-05-30	Not applicable	US
Alka-Seltzer Plus Night Cold Formula (Lemon)	Acetylsalicylic acid Dextromethorphan Doxylamine Phenylephrine	Tablet, effervescent	Oral	Bayer	2008-04-30	Not applicable	US
Alka-Seltzer Plus Night Cold Medicine	Acetylsalicylic acid Dextromethorphan Doxylamine Phenylephrine	Tablet, effervescent	Oral	Bayer Health Care Llc, Consumer Care	2010-08-01	Not applicable	US
Alka-Seltzer Plus Night Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Powder, for solution	Oral	Bayer	2014-04-17	Not applicable	US
Alka-Seltzer Plus Severe Allergy Sinus Congestion And Headache Formula	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc, Consumer Care	2012-08-01	Not applicable	US
Alka-Seltzer Plus Severe Cold and Cough Night	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Bayer Health Care Llc.	2015-07-31	Not applicable	US
Alka-Seltzer Plus Severe Cough Mucus and Congestion Day and Night	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit	Oral	Bayer Health Care Llc.	2017-05-30	Not applicable	US
Alka-Seltzer Plus Severe Sinus Congestion and Cough Day and Night	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Bayer Health Care Llc, Consumer Care	2012-07-03	Not applicable	US
Alka-Seltzer Plus Severe Sinus Congestion and Cough Liquid Gels Night	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc.	2017-02-27	Not applicable	US
Alka-Seltzer Plus Severe Sinus Congestion, Allergy and Cough	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc.	2013-10-30	2018-11-30	US
All Nite	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Major	2012-11-19	Not applicable	US
All-Nite Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Major	2009-02-18	Not applicable	US
Allergy and Cough	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Western Family Foods	2014-03-28	Not applicable	US
Apo-doxylamine/b6	Doxylamine Pyridoxine	Tablet, delayed release	Oral	Apotex Corporation	Not applicable	Not applicable	Canada
Aurophen Cold Multi Symptom	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Aurohealth LLC	2015-04-30	Not applicable	US
AuroQuil COLD and FLU Nighttime Relief	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Aurohealth LLC	2015-07-27	Not applicable	US
AuroQuil Cough Nighttime Cough Relief	Dextromethorphan Doxylamine	Solution	Oral	Aurohealth LLC	2015-07-27	Not applicable	US
AuroQuil Severe Cold and Flu Nighttime Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Aurohealth LLC	2015-05-31	Not applicable	US
Aurotussin Maximum Strength Daytime and Nighttime Cough Relief	Dextromethorphan Dextromethorphan Doxylamine Guaifenesin	Kit		Aurohealth LLC	2016-05-27	Not applicable	US
Basic Care Nighttime	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	L. Perrigo Company	2017-08-23	Not applicable	US
Being Well Cold and Flu Relief PM	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Save A Lot Food Stores, Ltd.	2011-10-12	Not applicable	US
Being Well Cold Flu Relief PM Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Save A Lot Food Stores, Ltd.	2006-11-15	Not applicable	US
Being Well Night Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Save A Lot Food Stores, Ltd.	2015-09-14	Not applicable	US
Buckley's Cold & Sinus Night	Acetaminophen Doxylamine Pseudoephedrine	Tablet	Oral	The Buckley's Company	Not applicable	Not applicable	Canada
Buckley's Complete Nighttime Softgels	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	The Buckley's Company	2010-08-02	Not applicable	Canada
Buckley's Nighttime Cold and Sinus	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	The Buckley's Company	2008-07-21	Not applicable	Canada
Care One Cold Mutli Symptom	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	American Sales Company	2015-10-19	Not applicable	US
Careone Allergy and Cough Severe Sinus Congestion	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	American Sales Company	2016-07-06	Not applicable	US
CareOne Cold and Cough	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	American Sales Company	2005-10-28	Not applicable	US
Careone Cold Max	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	American Sales Company	2016-03-30	Not applicable	US
CareOne Daytime Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		American Sales Company	2016-11-02	Not applicable	US
CareOne Daytime Nighttime Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		American Sales Company	2014-09-08	Not applicable	US
CareOne Night TIme Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	American Sales Company	2016-04-11	Not applicable	US
CareOne Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	American Sales Company	2016-04-15	Not applicable	US
CareOne NightTime Cough	Dextromethorphan Doxylamine	Solution	Oral	American Sales Company	2004-05-18	Not applicable	US
CareOne Nighttime Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	American Sales Company	2016-04-11	Not applicable	US
CareOne Nitetime Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	American Sales Company	2013-08-13	Not applicable	US
CareOne Nitetime Severe Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	American Sales Company	2015-10-12	Not applicable	US
Careone Severe Sinus Congestion	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	American Sales Company	2014-08-30	Not applicable	US
CareOne Tussin DM Nighttime Cough	Dextromethorphan Doxylamine	Solution	Oral	American Sales Company	2016-08-31	Not applicable	US
Circle K Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Lil' Drug Store Products, Inc.	2014-11-01	Not applicable	US
ClearTime	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Hyvee	2015-02-16	Not applicable	US
Cold & Flu	Acetaminophen Acetaminophen Dextromethorphan Dextromethorphan Doxylamine Pseudoephedrine Pseudoephedrine	Capsule; Kit	Oral	Vita Health Products Inc	2012-08-14	Not applicable	Canada
Cold & Flu Nighttime	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Arrow Otc Company	2007-12-07	2011-08-03	Canada
Cold & Flu Relief Nighttime	Acetaminophen Dextromethorphan Doxylamine	Capsule	Oral	Vita Health Products Inc	Not applicable	Not applicable	Canada
Cold & Sinus Liquid Capsules	Acetaminophen Acetaminophen Dextromethorphan Dextromethorphan Doxylamine Pseudoephedrine Pseudoephedrine	Capsule; Kit	Oral	Vita Health Products Inc	2016-06-01	Not applicable	Canada
Cold and Cough	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	H.E.B.	2014-07-14	Not applicable	US
Cold and Cough Nighttime	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Cvs Health	2007-07-28	Not applicable	US
Cold and Cough Nighttime Cool Blast	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2014-06-30	Not applicable	US
Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Hyvee	2014-03-24	Not applicable	US
Cold and Flu Day Night	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Hyvee	2014-10-14	Not applicable	US
Cold and Flu Daytime Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		L&R Distributors, Inc.	2007-09-19	Not applicable	US
Cold and Flu DayTime, NightTime Severe	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Walmart Stores	2015-08-01	Not applicable	US
Cold and Flu Daytime, Nighttime, Maximum Strength	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Walgreen	2015-08-01	Not applicable	US
Cold and Flu Daytime, Nighttime, Multi-Symptom	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Walgreen	2015-03-01	Not applicable	US
Cold and Flu Medicine - Night Time Formula	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Pharmetics (2011) Inc.	2006-04-10	2010-07-12	Canada
Cold and Flu Multi-Symptom Daytime Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Army + Air Force Exchange Service	2013-11-01	Not applicable	US
Cold and Flu Nighttime	Acetaminophen Dextromethorphan Doxylamine	Capsule	Oral	L&R Distributors, Inc.	2007-09-10	Not applicable	US
Cold and Flu Nighttime D	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Solution	Oral	Walgreen	2014-02-05	Not applicable	US
Cold and Flu Nighttime Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	L&R Distributors, Inc.	2015-03-01	Not applicable	US
Cold and Flu Nighttime Multi-symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Cardinal Health	2015-03-01	Not applicable	US
Cold and Flu Nighttime Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Fred's	2015-07-31	Not applicable	US
Cold and Flu Nighttime/Multi-Symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Walgreen	2015-03-01	Not applicable	US
Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Walgreen	2012-08-07	Not applicable	US
Cold and Flu Relief Daytime Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Rite Aid	2012-10-13	Not applicable	US
Cold and Flu Relief Multi symptom	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit	Oral	Win Co Foods, Llc,	2014-12-31	Not applicable	US
Cold and Flu Relief Multi Symptom Nighttime	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Win Co Foods, Llc,	2014-12-31	Not applicable	US
Cold and Flu Relief Multi-Symptom	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Army + Air Force Exchange Service	2015-03-01	Not applicable	US
Cold and Flu Relief Multi-Symptom, Day, Night	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Lnk International, Inc.	2015-03-01	Not applicable	US
Cold and Flu Relief Multi-Symptom, Nighttime	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Army + Air Force Exchange Service	2007-09-10	Not applicable	US
Cold and Flu Relief Nighttime	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Amerisource Bergen (Good Neighbor Pharmacy) 46122	2015-11-30	Not applicable	US
Cold and Flu Relief Nighttime Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	P And L Development Of New York Corporation (Ready In Case)	2014-07-31	Not applicable	US
Cold and Flu Relief NightTime, Multi-symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Army + Air Force Exchange Service	2015-03-01	Not applicable	US
Cold and Flu Relief Non-Drowsy / Daytime Severe / Nighttime Severe	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Cvs Health	2015-08-01	Not applicable	US
Cold and Flu Severe, Nighttime, Maximum Strength	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Tablet, film coated	Oral	Walgreen	2015-08-01	Not applicable	US
Cold and Sinus Nighttime Relief	Acetaminophen Doxylamine Pseudoephedrine	Tablet	Oral	Vita Health Products Inc	Not applicable	Not applicable	Canada
Cold and Sinus Relief Combo	Acetaminophen Acetaminophen Doxylamine Pseudoephedrine Pseudoephedrine	Kit; Tablet	Oral	Vita Health Products Inc	2013-06-24	Not applicable	Canada
Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Perrigo International	1997-01-09	Not applicable	Canada
Cold Max Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	P & L Development, LLC	2016-10-31	Not applicable	US
Cold Multi Symptom	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	H.E.B.	2015-12-21	Not applicable	US
Cold Relief Multi Symptom Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Cvs Health	2015-09-30	Not applicable	US
Cold/flu Medicine	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Perrigo International	2008-09-01	2014-02-24	Canada
Complete Liquid Capsules	Acetaminophen Acetaminophen Dextromethorphan Dextromethorphan Doxylamine Guaifenesin Pseudoephedrine Pseudoephedrine	Capsule; Kit	Oral	Vita Health Products Inc	2012-12-10	Not applicable	Canada
Complete Liquid Capsules Nighttime Relief	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Vita Health Products Inc	2017-05-25	Not applicable	Canada
ConRx NightTime	Acetaminophen Dextromethorphan Doxylamine	Tablet	Oral	Eagle Distributors,Inc.	2014-02-10	Not applicable	US
Contac Cold and Flu Cooling Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Meda Pharmaceuticals Ltd	2012-07-15	Not applicable	US
Core Values Night Time Relief	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Harmon Stores	2017-01-17	Not applicable	US
Coricidin HBP Nighttime Multi-Symptom Cold	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Bayer Health Care Llc.	2015-11-20	Not applicable	US
Cough	Dextromethorphan Doxylamine	Solution	Oral	Hyvee	2016-03-03	Not applicable	US
Cough and Sore Throat Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Meijer Distribution	2005-10-05	Not applicable	US
Cough and Sore Throat Nighttime	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Kinray	2006-08-28	Not applicable	US
Cough and Sore Throat Pain Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Hyvee	2008-07-20	Not applicable	US
Cough Day Night	Dextromethorphan Doxylamine	Kit		Hyvee	2015-02-18	Not applicable	US
Cough Multi Symptom	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Kinray	2006-08-28	Not applicable	US
COUGH Nighttime Cough Relief	Dextromethorphan Doxylamine	Solution	Oral	Chain Drug Consortium	2015-07-27	Not applicable	US
Cough Relief Daytime Nighttime	Dextromethorphan Doxylamine	Kit		Walgreen	2012-09-06	Not applicable	US
Cough Relief Nighttime	Dextromethorphan Doxylamine	Liquid	Oral	Walgreen	2002-08-16	Not applicable	US
CVS Daytime COLD and FLU RELIEF and Nighttime COLD and FLU RELIEF	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Pura Cap Pharmaceutical Llc.	2016-06-30	Not applicable	US
CVS Health Nighttime Cold and Flu Relief Single Serve Cups Cold and Flu Nighttime Relief	Acetaminophen Dextromethorphan Doxylamine	Powder, for solution	Oral	Cvs Health	2016-08-15	Not applicable	US
CVS Nighttime Cold/Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Cvs Health	2009-07-09	Not applicable	US
Dalmacol	Doxylamine Etafedrine Ethanol Hydrocodone Sodium Citrate	Liquid	Oral	Laboratoire Riva Inc	1997-03-26	Not applicable	Canada
Day and Night Cold and Flu Formula	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Walmart Stores	2017-08-23	Not applicable	US
DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Pura Cap Pharmaceutical Llc.	2016-07-28	Not applicable	US
Day Night Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Hyvee	2014-07-02	Not applicable	US
Day Relief Night Relief Free	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Western Family Foods	2007-08-17	Not applicable	US
Day Relief Night Relief Sinus PE	Acetaminophen Doxylamine Phenylephrine	Kit		Western Family Foods	2007-11-16	Not applicable	US
DAY TIME and NIGHT TIME COLD and FLU FORMULA	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Pura Cap Pharmaceutical Llc.	2016-07-20	Not applicable	US
Day Time and Night Time Sinus and Congestion	Acetaminophen Doxylamine Phenylephrine	Kit		Walgreens	2014-09-01	Not applicable	US
Day Time Night Time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Shopko Stores Operating	2013-09-19	Not applicable	US
Day Time Night Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Walgreens	2013-03-01	Not applicable	US
Day Time Night Time Sinus Relief	Acetaminophen Doxylamine Phenylephrine	Kit		Walgeens Company	2013-03-01	Not applicable	US
Day Time Nighttime Cough	Dextromethorphan Doxylamine	Kit		Hyvee	2012-08-30	Not applicable	US
Day-Time Night-Time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Chain Drug Consortium	2010-07-12	Not applicable	US
Daytime and Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Pura Cap Pharmaceutical Llc.	2017-07-12	Not applicable	US
Daytime and Nighttime Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Chain Drug Consortium	2015-07-09	Not applicable	US
Daytime and Nighttime Cold and Flu Relief Plus	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Chain Drug Consortium	2015-09-17	Not applicable	US
Daytime and Nighttime Cough Relief	Dextromethorphan Dextromethorphan Doxylamine Guaifenesin	Kit		Cvs Health	2016-05-02	Not applicable	US
DayTime and NiteTime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Pura Cap Pharmaceutical Llc.	2016-06-27	Not applicable	US
Daytime Cold and Flu and Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Kmart Corporation	2017-07-12	Not applicable	US
DayTime Cold and Flu Severe and NightTime Cold and Flu Severe	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Topco Associates	2016-06-28	Not applicable	US
Daytime Cough Nighttime Cough	Dextromethorphan Doxylamine	Kit		Cvs Health	2012-08-07	Not applicable	US
Daytime Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Shopko Stores Operating	2014-06-03	Not applicable	US
Daytime Nighttime ClearTime	Acetaminophen Doxylamine Phenylephrine	Kit		Hyvee	2015-02-07	Not applicable	US
DayTime NightTime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Safeway	2014-06-30	Not applicable	US
Daytime Nighttime Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Rite Aid	2014-06-13	Not applicable	US
Daytime Nighttime Cold and Flu Relief Multi-Symptom	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Family Dollar (FAMILY WELLNESS)	2013-06-30	Not applicable	US
Daytime Nighttime Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Safeway	2013-07-15	Not applicable	US
DayTime NightTime Cold/Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Quality Choice (Chain Drug Marketing Association, Inc.)	2013-01-15	Not applicable	US
DayTime Nighttime multi symptom cold and flu relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Shopko Stores Operating	2012-05-10	Not applicable	US
Daytime Nighttime Multi Symptom Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Cvs Health	2006-08-02	Not applicable	US
Daytime Nighttime Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Hyvee	2015-09-13	Not applicable	US
Daytime Nighttime Severe Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Rite Aid	2015-07-24	Not applicable	US
Daytime Nighttime Sinus Relief	Acetaminophen Doxylamine Phenylephrine	Kit		Hyvee	2013-11-30	Not applicable	US
DayTime Nite Time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Kroger	2007-08-31	Not applicable	US
Daytime Nitetime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Kroger	2014-05-31	Not applicable	US
Daytime Nitetime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Kroger	2014-11-03	Not applicable	US
DayTime Nitetime cold and flu relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Care One (American Sales Company)	2012-08-14	Not applicable	US
DayTime NiteTime Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit	Oral	Care One (American Sales Company)	2014-10-30	Not applicable	US
Daytime Nitetime Sinus	Acetaminophen Doxylamine Phenylephrine	Kit		Meijer Distribution	2007-08-10	Not applicable	US
DayTime Nitetime Sinus Relief	Acetaminophen Doxylamine Phenylephrine	Kit		Topcare (Topco Associates Llc)	2013-01-15	Not applicable	US
Daytime PE Nitetime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Publix Supermarkets, Inc.	2008-10-15	Not applicable	US
Daytime Sinus Relief and Nighttime Sinus Relief	Acetaminophen Doxylamine Phenylephrine	Kit		Pura Cap Pharmaceutical Llc.	2016-08-02	Not applicable	US
Daytime/Nighttime Cold and Flu Multi-Symptom Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		L&R Distributors, Inc.	2015-03-01	Not applicable	US
DayTime/NiteTime Severe Cold and Flu Maximum Strength	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Meijer Distribution	2015-07-13	Not applicable	US
DDM Day time and Nite time cold and flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Pura Cap Pharmaceutical Llc.	2016-06-20	Not applicable	US
Delsym Night Time Multi-Symptom	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Reckitt Benckiser	2011-07-01	Not applicable	US
DG Day Time Cold and Flu Formula and Night Time Cold and Flu Formula	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Pura Cap Pharmaceutical Llc.	2016-06-15	Not applicable	US
DG Health cold and flu relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Dolgencorp	2009-10-03	Not applicable	US
Dg Health Cold and Flu Relief Night Time	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Dolgencorp	2009-11-17	Not applicable	US
Dg Health Cold and Flu Relief Nite Time	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Dolgencorp	2009-11-21	Not applicable	US
DG Health Cold Max	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Dolgencorp	2016-05-20	Not applicable	US
Dg Health Cough and Sore Throat Nite Time	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Dolgencorp	2010-02-06	Not applicable	US
Dg Health Cough Night Time	Dextromethorphan Doxylamine	Solution	Oral	Dolgencorp	2009-11-21	Not applicable	US
Dg Health Night Time Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Dolgencorp	2011-08-17	Not applicable	US
DG Health Pain Relief Cold Night Time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Dolgencorp	2015-09-30	Not applicable	US
DG Health Tussin	Dextromethorphan Doxylamine	Solution	Oral	Dolgencorp	2016-04-25	Not applicable	US
Diclectin	Doxylamine Pyridoxine	Tablet, delayed release	Oral	Duchesnay Inc.	1983-12-31	Not applicable	Canada
Diclegis	Doxylamine Pyridoxine	Tablet, delayed release	Oral	Duchesnay Inc.	2013-05-15	Not applicable	US
Equaline Daytime and Nighttime Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Supervalu	2012-08-14	Not applicable	US
Equaline Daytime Nighttime Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Supervalu	2011-07-26	Not applicable	US
Equaline night time cough	Dextromethorphan Doxylamine	Liquid	Oral	Supervalu	2004-09-21	Not applicable	US
Equaline Nighttime	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Supervalu	2011-08-04	Not applicable	US
Equaline Nighttime Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Supervalu	2014-02-16	Not applicable	US
Equaline Nighttime Cough Relief	Dextromethorphan Doxylamine	Solution	Oral	Supervalu	2014-05-20	Not applicable	US
Equaline Nighttime Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Supervalu	2014-07-31	Not applicable	US
Equate Daytime Nitetime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Walmart Stores	2008-02-09	Not applicable	US
Equate DayTime NiteTime Severe	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Walmart Stores	2014-08-12	Not applicable	US
Equate Nighttime Liquid Capsules	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Ivax Pharmaceuticals Incorporated	Not applicable	Not applicable	Canada
Equate Nite Time Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Walmart Stores	2005-11-03	Not applicable	US
Equate Nite Time Cough	Dextromethorphan Doxylamine	Solution	Oral	Walmart Stores	2002-07-24	Not applicable	US
Equate NiteTime	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Walmart Stores	2014-01-28	Not applicable	US
Equate Nitetime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Walmart Stores	2006-07-17	Not applicable	US
Equate NiteTime DayTime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Walmart Stores	2013-08-15	Not applicable	US
Equate Nitetime Severe	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Walmart Stores	2014-07-27	Not applicable	US
Equate Sinus Night Time	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Walmart Stores	2010-08-04	Not applicable	US
Extra Strength Tylenol Cold and Flu Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Family Care Cold and Flu Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	United Exchange Corporation	2015-07-30	Not applicable	US
Family Care Cold and Flu Nighttime	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	United Exchange Corporation	2015-07-21	Not applicable	US
Family Care Cough Nighttime	Dextromethorphan Doxylamine	Liquid	Oral	United Exchange Corporation	2015-07-20	Not applicable	US
Fulton Street Market cold and flu	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Access Business Group	2010-07-15	Not applicable	US
Fulton Street Market Night Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Access Business Group	2012-08-22	Not applicable	US
Glentuss	Dextromethorphan Doxylamine Pseudoephedrine	Syrup	Oral	Glendale Inc	2015-12-05	Not applicable	US
Good Neighbor Pharmacy Cold Multi Symptom	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Amerisource Bergen	2015-10-26	Not applicable	US
Good Neighbor Pharmacy Cough and Sore Throat	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Amerisource Bergen	2006-02-14	Not applicable	US
Good Neighbor Pharmacy Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Amerisource Bergen	2014-12-23	Not applicable	US
Good Neighbor Pharmacy Night Time	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Amerisource Bergen	2006-04-19	Not applicable	US
Good Neighbor Pharmacy Night Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Amerisource Bergen	2011-10-16	Not applicable	US
Good Neighbor Pharmacy night time cough	Dextromethorphan Doxylamine	Solution	Oral	Amerisource Bergen	2003-06-30	Not applicable	US
Good Neighbor Pharmacy Night Time D	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Amerisource Bergen	1994-08-28	Not applicable	US
Good Neighbor Pharmacy Night Time Severe	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Amerisource Bergen	2014-01-09	Not applicable	US
Good Neighbor pharmacy severe night time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Amerisource Bergen	2015-09-03	2017-06-20	US
Good Neighbor Pharmacy Severe Sinus Congestion	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Amerisource Bergen	2014-12-21	Not applicable	US
Good Neoghbor Pharmacy Tussin DM MAX Nighttime Cough	Dextromethorphan Doxylamine	Solution	Oral	Amerisource Bergen	2016-08-25	Not applicable	US
Good Sense Cough and Sore Throat Night Time	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	L. Perrigo Company	2006-09-14	Not applicable	US
good sense DayTime Night Time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		L. Perrigo Company	2010-11-17	Not applicable	US
Good Sense Night Time	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	L. Perrigo Company	2006-04-07	Not applicable	US
Good Sense Night Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	L. Perrigo Company	2013-01-04	Not applicable	US
Good Sense Nighttime	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	L. Perrigo Company	2011-08-22	Not applicable	US
Good Sense Nighttime Cough	Dextromethorphan Doxylamine	Solution	Oral	L. Perrigo Company	2002-11-03	Not applicable	US
Good Sense NightTime DayTime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		L. Perrigo Company	2014-01-03	Not applicable	US
Good Sense Severe NightTime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	L. Perrigo Company	2015-10-21	Not applicable	US
Good Sense Severe NightTime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	L. Perrigo Company	2013-11-19	Not applicable	US
Good Sense Severe Sinus Congestion	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	L. Perrigo Company	2014-01-28	Not applicable	US
Harmon Face Values Night Time Relief	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Harmon Stores	2012-01-13	Not applicable	US
Harris Teeter DayTime NightTime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Harris Teeter	2015-11-21	Not applicable	US
Harris Teeter NightTime	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Harris Teeter	2015-09-24	Not applicable	US
Harris Teeter NightTime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Harris Teeter	2015-11-21	Not applicable	US
Health Mart Multi-Symptom Cold and Flu Night Time	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Mc Kesson (Health Mart)	2012-04-09	Not applicable	US
Health Mart Night Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Mc Kesson	2012-01-11	Not applicable	US
Healthy Accents Cold and Cough	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Dza Brands,	2014-03-31	Not applicable	US
Healthy Accents Cough and Sore Throat Night Time	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Dza Brands,	2008-02-24	Not applicable	US
Healthy Accents Day Time Night Time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Dza Brands,	2008-04-01	Not applicable	US
Healthy Accents Daytime Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Dza Brands,	2014-05-30	Not applicable	US
Healthy Accents Night Time Cough	Dextromethorphan Doxylamine	Solution	Oral	Dza Brands,	2008-01-29	Not applicable	US
Healthy Accents Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Dza Brands,	2008-01-29	Not applicable	US
HEB Day Time Night Time Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		H.E.B.	2016-04-14	Not applicable	US
Leader Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Cardinal Health	2016-11-15	Not applicable	US
Leader Nighttime Cough	Dextromethorphan Doxylamine	Solution	Oral	Cardinal Health	2016-11-29	Not applicable	US
Leader Nighttime Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Cardinal Health	2016-12-01	Not applicable	US
Leader Nite Time	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Cardinal Health	2011-11-30	Not applicable	US
Leader Nite Time Cold Flu Relief Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Cardinal Health	2006-06-20	Not applicable	US
Leader Nite Time Cough	Dextromethorphan Doxylamine	Liquid	Oral	Cardinal Health	2013-04-28	Not applicable	US
Leader Nite Time Multi Symptom Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Cardinal Health	2009-10-05	Not applicable	US
Leader nite time multi symptom cold flu relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Cardinal Health	2006-06-29	Not applicable	US
Leader Nite Time Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Cardinal Health	2013-11-21	Not applicable	US
Leader Severe Sinus Congestion	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Cardinal Health	2013-11-21	Not applicable	US
Lil Drug Store NyQuil Severe Cold and Flu, Max Strength	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Tablet, coated	Oral	Lil' Drug Store Products, Inc.	2016-04-07	Not applicable	US
Lortuss DM	Dextromethorphan Doxylamine	Liquid	Oral	Poly Pharmaceuticals	2011-03-14	Not applicable	US
Lortuss Lq	Doxylamine Pseudoephedrine	Liquid	Oral	Poly Pharmaceuticals	2011-02-22	Not applicable	US
Major Night Time Multi Symptom cold and flu relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Major	2012-03-01	Not applicable	US
Maximum Strength Night Time Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Pura Cap Pharmaceutical Llc.	2016-06-10	Not applicable	US
Maximum Strength Nighttime Cold/Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Pura Cap Pharmaceutical Llc.	2016-02-21	Not applicable	US
McKesson Nite Time	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Mc Kesson	2009-07-09	Not applicable	US
Mercodol With Decapryn	Doxylamine Etafedrine Hydrocodone Sodium Citrate	Syrup	Oral	Aventis Pharma Ltd.	1994-12-31	2001-07-20	Canada
Mersyndol With Codeine	Acetaminophen Codeine Doxylamine	Tablet	Oral	Sanofi Aventis	1982-12-31	Not applicable	Canada
Mucinex Fast-Max Day Severe Cold and Night Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Reckitt Benckiser	2015-07-15	Not applicable	US
Mucinex Fast-Max Night Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Reckitt Benckiser	2015-07-15	Not applicable	US
Mucinex Sinus - Max Day / Night	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Reckitt Benckiser	2015-07-15	Not applicable	US
Multi Symptom Cold and Flu Relief Nighttime	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	SMART SENSE (Kmart)	2016-07-31	Not applicable	US
Multi symptom Nighttime cold and flu relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Chain Drug Consortium	2012-11-15	Not applicable	US
Multi Symptom Nitetime	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Care One (American Sales Company)	2015-10-31	Not applicable	US
Multi-Symptom Daytime and Nighttime Cold and Flu Relief Plus	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Walgreens	2014-09-01	Not applicable	US
Multi-Symptom Nighttime Sinus Relief	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Pura Vation Pharmaceuticals Inc	2013-09-15	2017-01-04	US
Multi-Symptom Nitetime	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	P And L Development Of New York Corporation (Ready In Case)	2011-10-10	Not applicable	US
N - Time	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Spirit Pharmaceuticals, Llc	2010-05-30	Not applicable	US
N - Time Sinus	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Spirit Pharmaceuticals, Llc	2010-03-01	Not applicable	US
Neocitran Cold & Flu Syrup	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Syrup	Oral	Novartis	2004-07-30	2007-07-18	Canada
NEXT COLD and FLU NIGHTTIME	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Genomma Lab	2016-05-03	Not applicable	US
Next Night Severe Cold, Flu and Sore Throat	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Genomma Lab	2016-06-02	Not applicable	US
Next Night Time Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Genomma Lab	2015-01-21	Not applicable	US
Nicold Medicine for Adults	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Syrup	Oral	Tanta Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Night Cold Flu Cough and Allergy	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Humanwell Pura Cap Pharmaceutical (Wuhan), Ltd.	2013-05-29	Not applicable	US
Night Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Western Family Foods	2014-02-13	Not applicable	US
Night Relief Cold and Flu Liquid Capsules	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Banner Pharmacaps	2005-01-05	2009-08-07	Canada
Night Relief Cough	Dextromethorphan Doxylamine	Liquid	Oral	Western Family Foods	2002-10-21	Not applicable	US
Night Relief Free	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Western Family Foods	2009-09-15	Not applicable	US
Night Relief Multi Symptom Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Western Family Foods	2007-05-09	Not applicable	US
Night Relief sinus	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Western Family Foods	2012-07-12	Not applicable	US
Night Time	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Shopko Stores Operating	2014-06-02	Not applicable	US
Night Time Cherry	Dextromethorphan Doxylamine	Liquid	Oral	Dollar General	2009-02-17	2017-06-20	US
Night Time Cherry Pseudo-Free	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Safeway	2009-01-23	2017-06-03	US
Night Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Safeway	1994-07-19	Not applicable	US
NIGHT TIME COLD and FLU CHERRY	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Marc Glassman, Inc.	2017-07-15	Not applicable	US
NIGHT TIME COLD and FLU FORMULA	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Pura Cap Pharmaceutical Llc.	2016-07-14	Not applicable	US
Night Time Cold and Flu Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	H.E.B.	2011-06-10	Not applicable	US
Night Time Cold and Flu Original	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Marc Glassman, Inc.	2017-07-20	Not applicable	US
Night Time Cold and Flu ReadyInCase	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	P & L Development, LLC	2014-10-31	Not applicable	US
Night Time Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2015-08-31	Not applicable	US
Night Time Cold and Flu Relief Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Fred's	2015-10-31	Not applicable	US
Night Time Cold and Flu Severe	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Topco Associates	2016-06-02	Not applicable	US
Night Time Cold and Flue Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Allegiant Health	2015-03-03	Not applicable	US
Night Time Cold Max	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Dolgencorp	2016-03-04	Not applicable	US
Night Time Cold/Flu Relief Cherry	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Kareway Product, Inc.	2011-08-26	Not applicable	US
Night time cold/flu relief multi symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Shopko Stores Operating	2012-08-30	Not applicable	US
Night Time Cold/Flu Relief Original	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Kareway Product, Inc.	2011-08-26	Not applicable	US
Night Time Cough	Dextromethorphan Doxylamine	Liquid	Oral	Safeway	2015-06-30	Not applicable	US
Night Time Cough and Sore Throat Cool Blast	Acetaminophen Dextromethorphan Doxylamine	Syrup	Oral	Cvs Health	2009-07-08	2017-05-12	US
Night Time Cough Cherry	Dextromethorphan Doxylamine	Liquid	Oral	Rite Aid	2009-08-11	2017-06-20	US
Night Time Cough Relief	Dextromethorphan Doxylamine	Solution	Oral	H.E.B.	2003-02-25	Not applicable	US
Night Time Day Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Hyvee	2007-09-24	Not applicable	US
Night Time Gelcap	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Kareway Product, Inc.	2011-06-01	Not applicable	US
Night Time Liquid Caps Cold Flu Multi symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	H.E.B.	2013-08-14	Not applicable	US
Night time multi symptom cold/flu relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Fred's	2012-07-02	Not applicable	US
Night Time Multi Symptom Flu Cold Medicine	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Salado Sales, Inc.	2015-03-01	Not applicable	US
Night Time Multi Symptom Relief	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Strides Pharma Inc	Not applicable	Not applicable	Canada
Night Time MULTI-SYMPTOM COLD/FLU RELIEF	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Chain Drug Consortium	2012-09-01	Not applicable	US
Night Time Original Pseudo-Free	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Select Brand	2009-07-14	2017-06-03	US
Night Time Pseudo-Free	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Rite Aid	2009-10-16	Not applicable	US
Night Time Relief	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Strides Pharma Inc	Not applicable	Not applicable	Canada
Night Time Severe Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Pura Cap Pharmaceutical Llc.	2016-06-09	Not applicable	US
Night Time Sinus	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Fred's	2012-12-05	Not applicable	US
Night Time Sinus and Congestion	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Chain Drug Consortium	2015-10-12	Not applicable	US
Night Time Sinus Relief	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Pura Cap Pharmaceutical Llc.	2016-07-15	Not applicable	US
Night Time Softgels	Acetaminophen Dextromethorphan Doxylamine	Capsule	Oral	Strides Pharma Inc	Not applicable	Not applicable	Canada
Night-Time Cherry MULTI-SYMPTOM COLD/FLU RELIEF	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Chain Drug Consortium	2012-09-01	Not applicable	US
Night-Time COUGH RELIEF	Dextromethorphan Doxylamine	Liquid	Oral	Discount Drug Mart	2014-10-27	Not applicable	US
Night-time Multi-symptom Cold/flu Cherry	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	De Moulas Market Basket	2012-10-01	Not applicable	US
Night-time Multi-symptom Cold/flu Original	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	De Moulas Market Basket	2012-10-01	Not applicable	US
Night-Time Multi-Symptom Cold/Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Discount Drug Mart	2014-11-19	Not applicable	US
Night-Time Original MULTI-SYMPTOM COLD/FLU RELIEF	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Chain Drug Consortium	2012-09-01	Not applicable	US
Nightcap Cold and Flu Liquid Gels	Acetaminophen Dextromethorphan Doxylamine	Capsule	Oral	Accucaps Industries Limited	Not applicable	Not applicable	Canada
Nightcap Complete Liquid Gels	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Accucaps Industries Limited	Not applicable	Not applicable	Canada
NightRelief DayRelief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Western Family Foods	2012-02-02	Not applicable	US
NightRelief Free Multi symptom cold flu	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Western Family Foods	2006-05-01	Not applicable	US
NightTime	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Hannaford Brothers Company	2006-06-21	Not applicable	US
Nighttime 325 Liqua Caps	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Jamp Pharma Corporation	Not applicable	Not applicable	Canada
Nighttime Cold & Flu Liquid Capsules	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Vita Health Products Inc	1996-12-31	2008-08-05	Canada
Nighttime Cold & Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule	Oral	Apotex Corporation	2014-09-22	Not applicable	Canada
Nighttime Cold & Flu Relief Syrup	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Syrup	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Shopko Stores Operating	2013-08-05	Not applicable	US
Nighttime Cold and Flu Cherry	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Select Brand Dist.	2013-12-06	Not applicable	US
Nighttime Cold and Flu Extra Strength Medicine	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Jamp Pharma Corporation	Not applicable	Not applicable	Canada
Nighttime Cold and Flu Lil Drug Store Products	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Lil' Drug Store Products, Inc.	2014-12-01	Not applicable	US
Nighttime Cold and Flu Liquid Capsules	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Vita Health Products Inc	1997-02-19	2003-11-07	Canada
NightTime Cold and Flu Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Mc Kesson (Health Mart)	2015-12-31	Not applicable	US
Nighttime Cold and Flu original	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Marc Glassman, Inc.	2014-08-31	Not applicable	US
Nighttime Cold and Flu ReadyInCase	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	P & L Development, LLC	2014-11-30	Not applicable	US
Nighttime Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Walgreen	2011-08-08	Not applicable	US
Nighttime Cold and Flu Relief Multi-Symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Family Dollar (FAMILY WELLNESS)	2013-06-30	Not applicable	US
Nighttime Cold and Flu Relief Plus	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule	Oral	Chain Drug Consortium	2015-09-23	Not applicable	US
Nighttime Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	LIVE BETTER (The Great Atlantic & Pacific Tea Company)	2013-05-31	Not applicable	US
Nighttime Cold Max	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Family Dollar	2016-06-29	Not applicable	US
Nighttime Cold Medicine	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Jamp Pharma Corporation	Not applicable	Not applicable	Canada
Nighttime Cold Multi-Symptom Cool Blast	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Amerisource Bergen (Good Neighbor Pharmacy) 46122	2011-03-04	Not applicable	US
Nighttime Cough	Dextromethorphan Doxylamine	Liquid	Oral	Walgreen	2002-08-16	Not applicable	US
Nighttime Cough all night cough relief	Dextromethorphan Doxylamine	Liquid	Oral	P & L Development, LLC	2014-07-31	Not applicable	US
Nighttime Cough and Sore Throat Liquid	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Jamp Pharma Corporation	Not applicable	Not applicable	Canada
NightTime Cough DM Maximum Strength	Dextromethorphan Doxylamine	Liquid	Oral	Win Co Foods, Llc,	2016-06-30	Not applicable	US
Nighttime Cough Relief	Dextromethorphan Doxylamine	Liquid	Oral	Fred's	2015-07-31	Not applicable	US
Nighttime Cough. Cold. Flu Gel Capsules	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Apotex Inc., Private Label Division	Not applicable	Not applicable	Canada
Nighttime D Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Hyvee	1994-02-14	Not applicable	US
Nighttime D Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Walgreen	2002-06-19	Not applicable	US
Nighttime Daytime Cough	Dextromethorphan Doxylamine	Kit		Walgreen	2014-02-25	Not applicable	US
Nighttime Liqua Caps	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Jamp Pharma Corporation	2006-02-13	Not applicable	Canada
NightTime Maximum Strength Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Chain Drug Marketing Association	2016-08-03	Not applicable	US
Nighttime Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Cvs Health	2006-06-09	Not applicable	US
Nighttime Multi Symptom Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Family Dollar (FAMILY WELLNESS)	2015-08-31	Not applicable	US
Nighttime Multi-Symptom Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Walgreen	2007-09-10	Not applicable	US
NightTime Multi-Symptom Flu Cold	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Salado Sales, Inc.	2007-09-10	Not applicable	US
NightTime Relief Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Fred's	2015-06-26	Not applicable	US
Nighttime severe	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Shopko Stores Operating	2015-09-02	Not applicable	US
Nighttime Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	H.E.B.	2016-04-11	Not applicable	US
Nighttime Severe Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Pura Cap Pharmaceutical Llc.	2016-07-27	Not applicable	US
Nighttime sinus	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Good Sense (Geiss, Destin & Dunn, Inc.)	2012-07-01	Not applicable	US
Nighttime Sinus and Congestion Relief	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Pura Cap Pharmaceutical Llc.	2016-07-27	Not applicable	US
Nighttime Sinus Multi symptom	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Chain Drug Consortium	2012-10-18	Not applicable	US
NightTime Sinus Relief	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Humanwell Pura Cap Pharmaceutical (Wuhan), Ltd.	2013-06-15	Not applicable	US
Nite Time	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Kroger	2014-06-21	Not applicable	US
Nite Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Rite Aid	2006-05-09	Not applicable	US
Nite Time Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Kroger	2006-04-05	Not applicable	US
Nite Time Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	We Care Distributor Inc.	2016-08-10	Not applicable	US
Nite Time Cold Medicine	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Rij Pharmaceutical Corporation	1999-03-16	Not applicable	US
Nite Time Cold Medicine Cherry Flavor	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Rij Pharmaceutical Corporation	1999-03-16	Not applicable	US
Nite Time Cold/Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Nash Finch Company (Our Family)	2013-05-31	Not applicable	US
Nite Time Day Time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Kroger	2011-11-12	Not applicable	US
Nite Time Multi symptom cold flu relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Kroger	2009-08-05	Not applicable	US
Nite Time multi symptom cold/flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Kroger	2006-05-09	Not applicable	US
Nite time Severe Cold and Flu Maximum Strength	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Tablet, film coated	Oral	Meijer Distribution	2015-08-01	Not applicable	US
Nite-Time Cold and Flu Multi-Symptom Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Preferred Plus (Kinray)	2013-03-31	Not applicable	US
Nite-Time COLD/FLU ORIGINAL	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Salado Sales, Inc.	2012-01-16	Not applicable	US
Nite-TimeCOLD/FLU CHERRY COLD/FLU CHERRY	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Salado Sales, Inc.	2012-01-31	Not applicable	US
Nitecap Sinus Liquid Gels	Acetaminophen Doxylamine Phenylephrine	Capsule	Oral	Accucaps Industries Limited	Not applicable	Not applicable	Canada
NiteTime	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Kroger	1994-05-09	Not applicable	US
Nitetime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Kroger	2014-10-06	Not applicable	US
Nitetime cold and flu relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Care One (American Sales Company)	2012-08-01	Not applicable	US
NiteTime Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Meijer	2014-10-30	Not applicable	US
Nitetime Cold Medicine	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Ivc Industries, Hall Division	1997-11-24	1998-07-17	Canada
Nitetime Cold Medicine Liq	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Jamp Pharma Corporation	1992-12-31	Not applicable	Canada
Nitetime Cold Medicine Original and Cherry	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Westcan Pharmaceuticals Ltd.	Not applicable	Not applicable	Canada
NiteTime Cold plus Flu Releif	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2014-10-30	Not applicable	US
NiteTime Cold/Flu, Multi-Symptom Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Walmart Stores	2016-03-09	Not applicable	US
NiteTime Cough	Dextromethorphan Doxylamine	Solution	Oral	Kroger	2002-11-20	Not applicable	US
NiteTime Cough DayTime Cough	Dextromethorphan Doxylamine	Kit		Meijer Distribution	1992-01-10	Not applicable	US
Nitetime D	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Meijer Distribution	1994-03-29	Not applicable	US
Nitetime D multi symptom cold flu relief	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Meijer Distribution	1994-02-01	Not applicable	US
NiteTime DayTime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Meijer Distribution	2013-12-30	Not applicable	US
NiteTime DayTime Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Kroger	2014-09-24	Not applicable	US
NiteTime Multi-Symptom Cold/Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Greenbrier International, Inc.	2013-01-04	Not applicable	US
NiteTime Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Kroger	2014-08-13	Not applicable	US
Nitetime Severe Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Western Family Foods	2014-09-26	Not applicable	US
NiteTime Sinus	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Meijer	2010-09-14	Not applicable	US
Nitetime Sinus Relief	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Topcare (Topco Associates Llc)	2012-09-01	Not applicable	US
NyQuil Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Lil' Drug Store Products, Inc.	2010-09-16	Not applicable	US
Nyquil Liquicaps	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Procter And Gamble	1993-12-31	2005-07-28	Canada
NyQuil Severe	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Tablet	Oral	Navajo Manuracturing Company	2016-09-21	Not applicable	US
NyQuil Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Tablet, coated	Oral	Jc World Bell Wholesale Co., Inc.	2016-05-26	Not applicable	US
Nyquil Sinus Liquicaps	Acetaminophen Doxylamine Phenylephrine	Capsule	Oral	Procter And Gamble	2006-06-11	Not applicable	Canada
Original Night-Time MULTI-SYMPTOM COLD/FLU RELIEF	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Discount Drug Mart	2014-10-21	Not applicable	US
P.M. Cold Relief Formula	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Ivax Pharmaceuticals Incorporated	Not applicable	Not applicable	Canada
PMS-doxylamine-pyridoxine	Doxylamine Pyridoxine	Tablet, delayed release	Oral	Pharmascience Inc	2017-07-10	Not applicable	Canada
Poly Hist Forte	Doxylamine Phenylephrine	Tablet	Oral	Poly Pharmaceuticals	2013-10-01	Not applicable	US
Preferred Plus Severe Nite Time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Kinray	2014-07-17	Not applicable	US
Preferred Plus Severe Sinus Congestion	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Kinray	2015-02-16	Not applicable	US
Publix Cherry Flavor Nitetime	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Publix Supermarkets, Inc.	2009-07-09	Not applicable	US
Quality Choice Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2012-11-29	Not applicable	US
Ratio-calmydone	Doxylamine Etafedrine Hydrocodone Sodium Citrate	Syrup	Oral	Teva	1981-12-31	2017-04-04	Canada
Regular Strength Sinus Medication	Acetaminophen Doxylamine Pseudoephedrine	Tablet	Oral	Vita Health Products Inc	2004-12-04	2011-07-20	Canada
Rexall Daytime Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Dolgencorp	2012-09-14	Not applicable	US
Rexall Daytime Nighttime Cold Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Dolgencorp	2014-05-25	Not applicable	US
Rexall Night Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Dolgencorp	2010-08-10	Not applicable	US
Robitussin Complete Nighttime	Acetaminophen Dextromethorphan Doxylamine	Capsule	Oral	Pfizer Laboratories Div Pfizer Inc.	Not applicable	Not applicable	Canada
Robitussin Maximum Strength Nighttime Cough DM	Dextromethorphan Doxylamine	Liquid	Oral	Richmond Division of Wyeth	2013-03-01	Not applicable	US
Robitussin Peak Cold Nighttime Cold Plus Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Richmond Division of Wyeth	2012-04-15	Not applicable	US
Rx Act Cough and Sore Throat	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	H.E.B.	2006-07-04	Not applicable	US
Rx Act Nighttime Cold Flu Relief Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	H.E.B.	2011-06-10	Not applicable	US
Safetussin PM	Dextromethorphan Doxylamine	Liquid	Oral	Kramer Laboratories	2010-12-01	Not applicable	US
Safeway Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Safeway	2012-11-29	Not applicable	US
sanaflu Night-Time Xtreme Multi-Symptom Cold/Flu Relief Cherry Flavor	Acetaminophen Dextromethorphan Doxylamine	Syrup	Oral	Grandall Distributing Co., Inc.	2016-03-01	Not applicable	US
Sanaflu Nighttime Xtreme Multi Symptom Cold Flu Relief Cherry Flavor	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Grandall Distributing Co., Inc.	2017-08-31	Not applicable	US
Sanatos Night	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Pharmalab Enterprises Inc.	2010-02-04	Not applicable	US
Sever Daytime Cold and Flu and Sever Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Kmart Corporation	2017-07-12	Not applicable	US
Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Tablet, film coated	Oral	Hyvee	2015-09-08	Not applicable	US
Severe Cold and Flu Daytime/nighttime	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Target Corporation.	2015-08-01	Not applicable	US
Severe Cold and Flu Night time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Hyvee	2014-01-12	Not applicable	US
Severe Cold and Flu nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Tablet, film coated	Oral	Target Corporation.	2015-08-01	Not applicable	US
Severe Cold and Flu Nighttime Daytime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Hyvee	2014-05-19	Not applicable	US
Severe Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Rite Aid	2014-06-27	Not applicable	US
Severe Cold and Flu Relief Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Tablet, film coated	Oral	Rite Aid	2015-07-15	Not applicable	US
Severe Cold Plus Flu Daytime Nighttime	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Cvs Health	2017-07-14	Not applicable	US
Severe Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Cvs Health	2013-12-27	Not applicable	US
Severe Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, gelatin coated	Oral	Walgreens	2016-05-01	Not applicable	US
Severe Nighttime Severe Daytime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Cvs Health	2013-12-27	Not applicable	US
Severe Sinus Congestion	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Kroger	2014-05-14	Not applicable	US
Severe Sinus Congestion Allergy and Cough Formula	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Pura Cap Pharmaceutical Llc.	2016-06-29	Not applicable	US
ShopRite Ni Calm	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Wakfern Food Corporation	2014-05-12	Not applicable	US
ShopRite Ni Calm Cough	Dextromethorphan Doxylamine	Solution	Oral	Wakfern Food Corporation	2013-06-27	Not applicable	US
Signature Care daytime nighttime severe cold and flu relief	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Safeway	2017-06-01	Not applicable	US
Signature Care Nighttime Severe Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Safeway	2016-01-24	Not applicable	US
simply right Night Time	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Sam's West, Inc	2006-08-30	Not applicable	US
Sinex	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Procter And Gamble	2016-07-29	Not applicable	US
Sinex Nighttime Sinus	Acetaminophen Doxylamine Phenylephrine	Capsule	Oral	Procter And Gamble	Not applicable	Not applicable	Canada
Sinus Day/night Extra Strength	Acetaminophen Acetaminophen Doxylamine Pseudoephedrine Pseudoephedrine	Kit; Tablet	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Sinus Medication	Acetaminophen Doxylamine Pseudoephedrine	Tablet	Oral	Vita Health Products Inc	2003-03-07	Not applicable	Canada
Sinus Medication Day & Night	Acetaminophen Acetaminophen Doxylamine Pseudoephedrine Pseudoephedrine	Kit; Tablet	Oral	Vita Health Products Inc	2012-05-05	Not applicable	Canada
Sinus Medication Extra Strength Night Time	Acetaminophen Doxylamine Pseudoephedrine	Tablet	Oral	Pharmascience Inc	2002-12-08	2016-10-28	Canada
Sinus Medication Night Tablets	Acetaminophen Doxylamine Pseudoephedrine	Tablet	Oral	Pharmetics (2011) Inc.	2005-10-17	Not applicable	Canada
Sinus Nighttime	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Care One (American Sales Company)	2012-10-31	Not applicable	US
Sinus Relief Daytime Nighttime	Acetaminophen Doxylamine Phenylephrine	Kit		Walgreen	2005-07-21	Not applicable	US
Smart Sense Daytime Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Kmart Corporation	2013-04-15	Not applicable	US
Smart Sense Nighttime	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Kmart Corporation	2009-07-09	Not applicable	US
Smart Sense nighttime cold and flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Tablet, film coated	Oral	Kmart Corporation	2015-08-06	Not applicable	US
Smart Sense Nighttime Cold and Flu Relief Multi Symptom	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Kmart Corporation	2011-06-21	Not applicable	US
Smart Sense Nighttime Cough	Dextromethorphan Doxylamine	Liquid	Oral	Kmart Corporation	2010-12-03	Not applicable	US
Smart Sense NightTime DayTime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Kmart Corporation	2013-08-23	Not applicable	US
Smart Sense Severe Cold and Flu NightTime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Kmart Corporation	2013-11-22	Not applicable	US
SMITH BROS NIGHT TIME COUGH and CONGESTION	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Powder, for solution	Oral	Universal Holdings I Llc	2014-07-09	2015-12-29	US
Sound Body Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Big Lots Stores, Inc.	2017-03-30	Not applicable	US
Sunmark Nite Time	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Mc Kesson	2011-11-21	Not applicable	US
Sunmark nite time cold and flu	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Mc Kesson	2006-04-28	Not applicable	US
Sunmark Nite Time Cough	Dextromethorphan Doxylamine	Liquid	Oral	Mc Kesson	2003-07-03	Not applicable	US
Sunmark Nite Time D Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Mc Kesson	2003-08-24	Not applicable	US
Target Cold/Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Target Corporation.	2009-07-09	Not applicable	US
Topcare Clear Time	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Topco Associates	2015-02-15	2016-10-29	US
Topcare Cold and Cough	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Topco Associates	2006-03-09	Not applicable	US
TopCare Cold Max	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Topco Associates	2016-04-12	Not applicable	US
Topcare Cough and Sore Throat	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Topco Associates	2006-03-09	Not applicable	US
Topcare Day Time Nite Time	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Topco Associates	2007-11-27	2017-02-04	US
Topcare Day Time Nite Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Topco Associates	2015-09-12	Not applicable	US
Topcare Day Time Nite Time Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Topco Associates	2012-10-15	Not applicable	US
Topcare Daytime Nighttime Clear Time	Acetaminophen Doxylamine Phenylephrine	Kit		Topco Associates	2015-02-04	2016-10-19	US
TopCare Nite Time	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Topco Associates	2006-06-12	Not applicable	US
Topcare Nite Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Topco Associates	2006-06-12	Not applicable	US
Topcare Nite Time Cold and flu relief	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Topco Associates	2012-07-17	Not applicable	US
Topcare Nite Time Cold and Flu Relief Multi Symptom Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Topco Associates	2006-06-12	Not applicable	US
Topcare Nite Time Cough	Dextromethorphan Doxylamine	Solution	Oral	Topco Associates	2002-12-10	Not applicable	US
Topcare Nite Time D	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Topco Associates	1989-12-15	Not applicable	US
Topcare Nite Time Day Time Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Topco Associates	2014-04-29	Not applicable	US
Topcare Nite Time Day Time Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Topco Associates	2011-12-15	Not applicable	US
Topcare Nite Time Multi Symptom Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Topco Associates	2009-07-28	Not applicable	US
TopCare Pain Relief Cold Nightttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Topco Associates	2016-01-31	Not applicable	US
Topcare Severe Sinus Congestion	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Topco Associates	2014-06-22	2016-10-29	US
TopCare Tussin DM Nighttime Cough	Dextromethorphan Doxylamine	Solution	Oral	Topco Associates	2016-07-17	Not applicable	US
Tussin DM Cough Nighttime Maximum Strength	Dextromethorphan Doxylamine	Liquid	Oral	P & L Development, LLC	2016-09-30	Not applicable	US
Tussin DM Maximum Strength	Dextromethorphan Doxylamine	Liquid	Oral	Cvs Health	2014-05-31	Not applicable	US
Tussin Nighttime Cough Control	Dextromethorphan Doxylamine	Solution	Oral	Hyvee	2016-08-12	Not applicable	US
Tussin Nighttime Cough DM Maximum Strength	Dextromethorphan Doxylamine	Liquid	Oral	Family Dollar (FAMILY WELLNESS)	2016-07-31	Not applicable	US
Tylenol Cold & Flu Nighttime	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2005-08-22	2008-08-07	Canada
Tylenol Cold and Flu Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2007-01-12	2016-01-12	Canada
Tylenol Cold Max Night	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2015-04-13	Not applicable	US
Tylenol Cold Multi-symptom	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2006-07-01	2017-06-22	US
Tylenol Cold plus Flu Severe and Tylenol Cold Max	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2016-10-03	Not applicable	US
Up and Up Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Target Corporation.	2011-09-23	Not applicable	US
Up and Up Cold and Flu Relief Multi Symptom Day and Night Combo Pack	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Target Corporation.	2012-10-11	Not applicable	US
Up and Up Cold Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, gelatin coated	Oral	Target Corporation.	2014-02-05	Not applicable	US
Up and Up Cold Flu Relief Day Night	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Target Corporation.	2014-08-18	Not applicable	US
Up and Up Cold Flu Relief multi symptom night	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Target Corporation.	2009-06-11	Not applicable	US
Up and Up Daytime Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Target Corporation.	2014-07-30	Not applicable	US
Up and Up Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Target Corporation.	2015-04-15	Not applicable	US
Up and Up nighttime cough control	Dextromethorphan Doxylamine	Solution	Oral	Target Corporation.	2016-07-11	Not applicable	US
Up and Up Nighttime Daytime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Target Corporation.	2015-05-07	Not applicable	US
Up and Up severe cold and flu	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Target Corporation.	2016-07-19	Not applicable	US
Up and Up Severe Cold and Flu Nighttime	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Target Corporation.	2015-08-03	Not applicable	US
Vicks DayQuil and Vicks NyQuil Cherry Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit	Oral	Procter And Gamble	2013-07-01	Not applicable	US
Vicks DayQuil and Vicks NyQuil Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit	Oral	Procter And Gamble	2013-08-01	Not applicable	US
Vicks DayQuil and Vicks NyQuil Cold and Flu Multi-Symptom Relief/Cold and Flu Nighttime Relief	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit		Procter And Gamble	2014-03-21	Not applicable	US
Vicks DayQuil and Vicks NyQuil Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Guaifenesin Phenylephrine	Kit		Procter And Gamble	2014-07-31	Not applicable	US
Vicks DayQuil Tropical and Vicks NyQuil Cherry Cough	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Kit	Oral	Procter And Gamble	2013-08-01	Not applicable	US
Vicks Nyquil Adult Nighttime Colds Medicine	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Procter And Gamble	1990-12-31	2006-07-07	Canada
Vicks Nyquil Cold & Flu Nighttime Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Procter And Gamble	2012-07-09	Not applicable	Canada
Vicks NyQuil Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Mechanical Servants, Llc	2010-01-01	Not applicable	US
Vicks NyQuil Cold and Flu Nighttime Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule, liquid filled	Oral	Procter And Gamble	2011-06-09	Not applicable	US
Vicks NyQuil Cold and Flu Nighttime Relief and Vicks Childrens NyQuil Cold and Cough	Acetaminophen Chlorphenamine Dextromethorphan Doxylamine	Kit		Procter And Gamble	2012-07-23	2016-11-01	US
Vicks Nyquil Complete Cold & Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Liquid	Oral	Procter And Gamble	2014-08-15	Not applicable	Canada
Vicks Nyquil Complete Cold & Flu Caplets	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Tablet	Oral	Procter And Gamble	2015-07-08	Not applicable	Canada
Vicks NyQuil Cough	Dextromethorphan Doxylamine	Liquid	Oral	Procter And Gamble	2011-06-22	Not applicable	US
Vicks NyQuil D Cold And Flu Nighttime Relief	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Liquid	Oral	Procter And Gamble	2012-09-17	2016-11-01	US
Vicks NyQuil HBP Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Procter And Gamble	2017-02-01	Not applicable	US
Vicks Nyquil Liquicaps	Acetaminophen Dextromethorphan Doxylamine Pseudoephedrine	Capsule	Oral	Procter And Gamble	2004-03-01	2006-07-25	Canada
Vicks Nyquil Liquicaps Cold & Flu Multi-symptom Relief	Acetaminophen Dextromethorphan Doxylamine	Capsule	Oral	Procter And Gamble	2006-06-26	Not applicable	Canada
Vicks NyQuil Severe Cold and Flu	Acetaminophen Dextromethorphan Doxylamine Phenylephrine	Solution	Oral	Procter And Gamble	2014-07-21	Not applicable	US
Vicks Nyquil Sinus Liquicaps	Acetaminophen Doxylamine Pseudoephedrine	Capsule	Oral	Procter And Gamble	2005-07-01	2006-07-28	Canada
Vicks QlearQuil Daytime Sinus and Congestion and Nighttime Sinus and Congestion	Acetaminophen Doxylamine Phenylephrine	Kit		Procter And Gamble	2014-07-21	2018-03-05	US
Vicks QlearQuil Nighttime Sinus and Congestion	Acetaminophen Doxylamine Phenylephrine	Capsule, liquid filled	Oral	Procter And Gamble	2014-03-01	Not applicable	US
Walgreen Nighttime Cold and Flu Relief	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Walgreen	2009-07-09	Not applicable	US
Walgreens Adult Nighttime Wal Tussin DM Max Maximum Strength	Dextromethorphan Doxylamine	Solution	Oral	Walgreen	2017-09-08	Not applicable	US
WalTussin DM Max	Dextromethorphan Doxylamine Guaifenesin	Kit		Walgreen	2016-07-10	Not applicable	US
Welby Nighttime Cold and Flu	Acetaminophen Dextromethorphan Doxylamine	Solution	Oral	Aldi, Inc	2017-07-14	Not applicable	US
Zicam	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Matrixx Initiatives, Inc.	2007-07-16	Not applicable	US
Zicam Multi-symptom Cold & Flu Nighttime	Acetaminophen Dextromethorphan Doxylamine	Liquid	Oral	Zicam Llc	2008-10-30	2009-11-20	Canada

Categories

UNII

95QB77JKPL

CAS number

469-21-6

Weight

Average: 270.3694
Monoisotopic: 270.173213336

Chemical Formula

C₁₇H₂₂N₂O

InChI Key

HCFDWZZGGLSKEP-UHFFFAOYSA-N

InChI

InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3

IUPAC Name

dimethyl({2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethyl})amine

SMILES

CN(C)CCOC(C)(C1=CC=CC=C1)C1=CC=CC=N1

Pharmacology

Indication

Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.

Structured Indications

Pharmacodynamics

Doxylamine is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power far superior to virtually every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most powerful over-the-counter sedative available in the United States, and more sedating than many prescription hypnotics. In a study, it was found to be superior to even the barbiturate, phenobarbital for use as a sedative. Doxylamine is also a potent anticholinergic.

Mechanism of action

Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
Histamine H1 receptor	Protein	yes	antagonist	Human	P35367	details
Muscarinic acetylcholine receptor M1	Protein	unknown	antagonist	Human	P11229	details
Nuclear receptor subfamily 1 group I member 3	Protein	unknown	Not Available	Human	Q14994	details

Absorption

Readily absorbed via the gastrointestinal tract.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Hepatic.

Route of elimination

Not Available

Half life

10 hours

Clearance

Not Available

Toxicity

Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.

Affected organisms

Humans and other mammals

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
2,5-Dimethoxy-4-ethylamphetamine	2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Doxylamine.	Experimental, Illicit
3,4-Methylenedioxyamphetamine	3,4-Methylenedioxyamphetamine may decrease the sedative activities of Doxylamine.	Experimental, Illicit
3,4-Methylenedioxymethamphetamine	3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Doxylamine.	Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine	4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Doxylamine.	Experimental, Illicit
7-Nitroindazole	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of 7-Nitroindazole.	Experimental
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline	7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the anticholinergic activities of Doxylamine.	Experimental
Acepromazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.	Approved, Vet Approved
Aceprometazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.	Approved
Adipiplon	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of adipiplon.	Investigational
Agomelatine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.	Approved, Investigational
Alfaxalone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Alfaxalone.	Vet Approved
Alfentanil	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.	Approved, Illicit
Allopregnanolone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Sage 547.	Investigational
Alphacetylmethadol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Alphacetylmethadol.	Experimental, Illicit
Alprazolam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.	Approved, Illicit, Investigational
Amisulpride	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Amisulpride.	Approved, Investigational
Amitriptyline	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.	Approved
Amobarbital	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.	Approved, Illicit
Amoxapine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.	Approved
Amperozide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Amperozide.	Experimental
Amphetamine	Amphetamine may decrease the sedative activities of Doxylamine.	Approved, Illicit
Aripiprazole	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.	Approved, Investigational
Articaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Articaine.	Approved
Asenapine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Asenapine.	Approved
Azaperone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Azaperone.	Vet Approved
Azelastine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.	Approved
Baclofen	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Baclofen.	Approved
Barbital	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Barbital.	Illicit
Benmoxin	Benmoxin may increase the anticholinergic activities of Doxylamine.	Withdrawn
Benperidol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Benperidol.	Investigational
Benzocaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.	Approved
Benzphetamine	Benzphetamine may decrease the sedative activities of Doxylamine.	Approved, Illicit
Benzyl alcohol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.	Approved
Benzylpenicilloyl Polylysine	Doxylamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.	Approved
Betahistine	The therapeutic efficacy of Betahistine can be decreased when used in combination with Doxylamine.	Approved
Brexpiprazole	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.	Approved
Brimonidine	Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved
Bromazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.	Approved, Illicit
Brompheniramine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.	Approved
Brotizolam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.	Approved, Withdrawn
Bupivacaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.	Approved, Investigational
Buprenorphine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.	Approved, Illicit, Investigational, Vet Approved
Buspirone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Buspirone.	Approved, Investigational
Butabarbital	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.	Approved, Illicit
Butacaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Butacaine.	Vet Approved
Butalbital	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Butalbital.	Approved, Illicit
Butamben	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Butamben.	Approved
Butethal	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Butethal.	Approved, Illicit
Butorphanol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.	Approved, Illicit, Vet Approved
Carbamazepine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.	Approved, Investigational
Carbinoxamine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.	Approved
Carfentanil	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.	Illicit, Vet Approved
Carisoprodol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.	Approved
Caroxazone	Caroxazone may increase the anticholinergic activities of Doxylamine.	Withdrawn
Cetirizine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.	Approved
Chloral hydrate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.	Approved, Illicit, Vet Approved
Chlordiazepoxide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.	Approved, Illicit
Chlormezanone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.	Approved, Withdrawn
Chloroprocaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chloroprocaine.	Approved
Chlorphenamine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved
Chlorphentermine	Chlorphentermine may decrease the sedative activities of Doxylamine.	Illicit, Withdrawn
Chlorpromazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.	Approved, Vet Approved
Chlorprothixene	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.	Approved, Withdrawn
Chlorzoxazone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.	Approved
Cinchocaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Cinchocaine.	Approved, Vet Approved
Citalopram	The risk or severity of adverse effects can be increased when Doxylamine is combined with Citalopram.	Approved
Clemastine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Clemastine.	Approved
Clidinium	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Clidinium.	Approved
Clobazam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.	Approved, Illicit
clomethiazole	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.	Investigational
Clomipramine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.	Approved, Vet Approved
Clonazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.	Approved, Illicit
Clonidine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Clonidine.	Approved
Clorazepate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.	Approved, Illicit
Clozapine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Clozapine.	Approved
Cocaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Cocaine.	Approved, Illicit
Codeine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Codeine.	Approved, Illicit
Cyclizine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.	Approved
Cyclobenzaprine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.	Approved
Cyproheptadine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.	Approved
Dantrolene	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.	Approved
Dapiprazole	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dapiprazole.	Approved
Dapoxetine	The risk or severity of adverse effects can be increased when Doxylamine is combined with Dapoxetine.	Investigational
Deramciclane	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of deramciclane.	Investigational
Desflurane	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Desflurane.	Approved
Desipramine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.	Approved
Desloratadine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.	Approved, Investigational
Desvenlafaxine	The risk or severity of adverse effects can be increased when Doxylamine is combined with Desvenlafaxine.	Approved
Detomidine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Detomidine.	Vet Approved
Dexbrompheniramine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.	Approved
Dexmedetomidine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.	Approved, Vet Approved
Dextroamphetamine	Dextroamphetamine may decrease the sedative activities of Doxylamine.	Approved, Illicit
Dextromoramide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dextromoramide.	Experimental, Illicit
Dextropropoxyphene	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.	Approved, Illicit, Withdrawn
Dezocine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.	Approved
Diazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Diazepam.	Approved, Illicit, Vet Approved
Diethylpropion	Diethylpropion may decrease the sedative activities of Doxylamine.	Approved, Illicit
Difenoxin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.	Approved, Illicit
Dihydrocodeine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dihydrocodeine.	Approved, Illicit
Dihydroetorphine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dihydroetorphine.	Experimental, Illicit
Dihydromorphine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.	Experimental, Illicit
Dimenhydrinate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.	Approved
Diphenhydramine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved
Diphenoxylate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Diphenoxylate.	Approved, Illicit
Doramectin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Doramectin.	Vet Approved
Doxepin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.	Approved
DPDPE	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of DPDPE.	Investigational
Dronabinol	Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved, Illicit
Droperidol	Droperidol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved, Vet Approved
Drotebanol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Drotebanol.	Experimental, Illicit
Duloxetine	The risk or severity of adverse effects can be increased when Doxylamine is combined with Duloxetine.	Approved
Dyclonine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.	Approved
Ecgonine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ecgonine.	Experimental, Illicit
Ecopipam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ecopipam.	Investigational
Efavirenz	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.	Approved, Investigational
Eltanolone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pregnanolone.	Investigational
Enflurane	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Enflurane.	Approved, Vet Approved
Entacapone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Entacapone.	Approved, Investigational
Escitalopram	The risk or severity of adverse effects can be increased when Doxylamine is combined with Escitalopram.	Approved, Investigational
Estazolam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Estazolam.	Approved, Illicit
Eszopiclone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.	Approved
Ethanol	Ethanol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved
Ethchlorvynol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethchlorvynol.	Approved, Illicit, Withdrawn
Ethosuximide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.	Approved
Ethotoin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.	Approved
Ethyl carbamate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethyl carbamate.	Withdrawn
Ethyl loflazepate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethyl loflazepate.	Approved, Illicit
Ethylmorphine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.	Approved, Illicit
Etidocaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.	Approved
Etifoxine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.	Withdrawn
Etizolam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Etizolam.	Approved
Etomidate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Etomidate.	Approved
Etoperidone	The risk or severity of adverse effects can be increased when Doxylamine is combined with Etoperidone.	Approved
Etorphine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Etorphine.	Illicit, Vet Approved
Ezogabine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.	Approved
Felbamate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Felbamate.	Approved
Fencamfamine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fencamfamine.	Approved, Illicit, Withdrawn
Fentanyl	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.	Approved, Illicit, Investigational, Vet Approved
Fexofenadine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.	Approved
Flibanserin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.	Approved
Fludiazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fludiazepam.	Approved, Illicit
Flunarizine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.	Approved
Flunitrazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Flunitrazepam.	Approved, Illicit
Fluoxetine	The risk or severity of adverse effects can be increased when Doxylamine is combined with Fluoxetine.	Approved, Vet Approved
Flupentixol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.	Approved, Withdrawn
Fluphenazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.	Approved
Flurazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.	Approved, Illicit
Fluspirilene	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.	Approved
Fluticasone propionate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.	Approved
Fluvoxamine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluvoxamine.	Approved, Investigational
Fosphenytoin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.	Approved
Fospropofol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.	Approved, Illicit
Furazolidone	Furazolidone may increase the anticholinergic activities of Doxylamine.	Approved, Vet Approved
Gabapentin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.	Approved, Investigational
Gabapentin Enacarbil	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of gabapentin enacarbil.	Approved
Gamma Hydroxybutyric Acid	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Gamma Hydroxybutyric Acid.	Approved, Illicit
Gepirone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Gepirone.	Investigational
Glutethimide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.	Approved, Illicit
Guanfacine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.	Approved, Investigational
Halazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.	Approved, Illicit, Withdrawn
Haloperidol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.	Approved
Halothane	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Halothane.	Approved, Vet Approved
Heroin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Heroin.	Approved, Illicit
Hexobarbital	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.	Approved
Hyaluronidase	The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Doxylamine.	Approved, Investigational
Hydracarbazine	Hydracarbazine may increase the anticholinergic activities of Doxylamine.	Experimental
Hydrocodone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.	Approved, Illicit
Hydromorphone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.	Approved, Illicit
Hydroxyamphetamine	Hydroxyamphetamine hydrobromide may decrease the sedative activities of Doxylamine.	Approved
Hydroxyzine	Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved
Iloperidone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.	Approved
Imipramine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Imipramine.	Approved
Indalpine	The risk or severity of adverse effects can be increased when Doxylamine is combined with Indalpine.	Investigational, Withdrawn
Iproclozide	Iproclozide may increase the anticholinergic activities of Doxylamine.	Withdrawn
Iproniazid	Iproniazid may increase the anticholinergic activities of Doxylamine.	Withdrawn
Isocarboxazid	Isocarboxazid may increase the anticholinergic activities of Doxylamine.	Approved
Isoflurane	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.	Approved, Vet Approved
Ketamine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketamine.	Approved, Vet Approved
Ketazolam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.	Approved
Ketobemidone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.	Approved
Lamotrigine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.	Approved, Investigational
Levetiracetam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.	Approved, Investigational
Levobupivacaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.	Approved
Levocabastine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.	Approved
Levocetirizine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.	Approved
Levodopa	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Levodopa.	Approved
Levomethadyl Acetate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Levomethadyl Acetate.	Approved
Levomilnacipran	The risk or severity of adverse effects can be increased when Doxylamine is combined with Levomilnacipran.	Approved
Levorphanol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.	Approved
Lidocaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.	Approved, Vet Approved
Lisdexamfetamine	Lisdexamfetamine may decrease the sedative activities of Doxylamine.	Approved, Investigational
Lithium	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lithium.	Approved
Lofentanil	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.	Illicit
Loratadine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.	Approved
Lorazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.	Approved
Loxapine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Loxapine.	Approved
Lurasidone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.	Approved
Magnesium Sulfate	Magnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved, Vet Approved
Maprotiline	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.	Approved
Mebanazine	Mebanazine may increase the anticholinergic activities of Doxylamine.	Withdrawn
Meclizine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.	Approved
Medetomidine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Medetomidine.	Vet Approved
Melatonin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Melatonin.	Approved, Nutraceutical, Vet Approved
Melperone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Melperone.	Approved
Mephedrone	Mephedrone may decrease the sedative activities of Doxylamine.	Investigational
Mephentermine	Mephentermine may decrease the sedative activities of Doxylamine.	Approved
Mepivacaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine.	Approved, Vet Approved
Meprobamate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.	Approved, Illicit
Mesoridazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Mesoridazine.	Approved
Metaxalone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.	Approved
Methadone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methadone.	Approved
Methadyl Acetate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.	Approved, Illicit
Methamphetamine	Methamphetamine may decrease the sedative activities of Doxylamine.	Approved, Illicit
Methapyrilene	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methapyrilene.	Withdrawn
Methaqualone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.	Illicit, Withdrawn
Methocarbamol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.	Approved, Vet Approved
Methohexital	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methohexital.	Approved
Methotrimeprazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.	Approved
Methoxyflurane	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methoxyflurane.	Approved, Vet Approved
Methsuximide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.	Approved
Methylecgonine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of ECGONINE METHYL ESTER.	Experimental
Methylene blue	Methylene blue may increase the anticholinergic activities of Doxylamine.	Investigational
Methylphenobarbital	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methylphenobarbital.	Approved
Metyrosine	Doxylamine may increase the sedative activities of Metyrosine.	Approved
Midazolam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Midazolam.	Approved, Illicit
Milnacipran	The risk or severity of adverse effects can be increased when Doxylamine is combined with Milnacipran.	Approved
Minaprine	Minaprine may increase the anticholinergic activities of Doxylamine.	Approved
Minocycline	Minocycline may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved, Investigational
Mirtazapine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.	Approved
MMDA	MMDA may decrease the sedative activities of Doxylamine.	Experimental, Illicit
Moclobemide	Moclobemide may increase the anticholinergic activities of Doxylamine.	Approved
Molindone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Molindone.	Approved
Morphine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Morphine.	Approved, Investigational
Nabilone	Nabilone may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved, Investigational
Nalbuphine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.	Approved
Nefazodone	The risk or severity of adverse effects can be increased when Doxylamine is combined with Nefazodone.	Approved, Withdrawn
Nialamide	Nialamide may increase the anticholinergic activities of Doxylamine.	Withdrawn
Nitrazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.	Approved
Nitrous oxide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.	Approved, Vet Approved
Norflurane	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of 1,1,1,2 Tetrafluoroethane.	Investigational
Normethadone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Normethadone.	Approved, Illicit
Nortriptyline	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.	Approved
Octamoxin	Octamoxin may increase the anticholinergic activities of Doxylamine.	Withdrawn
Olanzapine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.	Approved, Investigational
Olopatadine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.	Approved
Ondansetron	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ondansetron.	Approved
Opium	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Opium.	Approved, Illicit
Orphenadrine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.	Approved
Osanetant	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Osanetant.	Investigational
Oxazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.	Approved
Oxethazaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.	Investigational
Oxprenolol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxprenolol.	Approved
Oxybuprocaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.	Approved
Oxycodone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.	Approved, Illicit, Investigational
Oxymorphone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.	Approved, Investigational, Vet Approved
Paliperidone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.	Approved
Paraldehyde	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.	Approved
Pargyline	Pargyline may increase the anticholinergic activities of Doxylamine.	Approved
Paroxetine	The risk or severity of adverse effects can be increased when Doxylamine is combined with Paroxetine.	Approved, Investigational
Pentazocine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.	Approved, Vet Approved
Pentobarbital	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.	Approved, Vet Approved
Perampanel	Perampanel may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved
Perazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Perazine.	Investigational
Perospirone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Perospirone.	Approved
Perphenazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.	Approved
Pethidine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pethidine.	Approved
Phenelzine	Phenelzine may increase the anticholinergic activities of Doxylamine.	Approved
Pheniprazine	Pheniprazine may increase the anticholinergic activities of Doxylamine.	Withdrawn
Phenobarbital	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.	Approved
Phenoxyethanol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.	Approved
Phenoxypropazine	Phenoxypropazine may increase the anticholinergic activities of Doxylamine.	Withdrawn
Phentermine	Phentermine may decrease the sedative activities of Doxylamine.	Approved, Illicit
Phenytoin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.	Approved, Vet Approved
Pimozide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pimozide.	Approved
Pipamperone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.	Approved
Pipotiazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.	Approved
Piritramide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Piritramide.	Investigational
Pirlindole	Pirlindole may increase the anticholinergic activities of Doxylamine.	Approved
Pivhydrazine	Pivhydrazine may increase the anticholinergic activities of Doxylamine.	Withdrawn
Pizotifen	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.	Approved
Pomalidomide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.	Approved
Pramipexole	Doxylamine may increase the sedative activities of Pramipexole.	Approved, Investigational
Pramocaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.	Approved
Prazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Prazepam.	Approved, Illicit
Pregabalin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.	Approved, Illicit, Investigational
Prilocaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.	Approved
Primidone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Primidone.	Approved, Vet Approved
Procaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Procaine.	Approved, Investigational, Vet Approved
Prochlorperazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.	Approved, Vet Approved
Promazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Promazine.	Approved, Vet Approved
Promethazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Promethazine.	Approved
Proparacaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.	Approved, Vet Approved
Propofol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Propofol.	Approved, Investigational, Vet Approved
Propoxycaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.	Approved
Protriptyline	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.	Approved
PSD502	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of PSD502.	Investigational
Pseudoephedrine	Pseudoephedrine may decrease the sedative activities of Doxylamine.	Approved
Quazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Quazepam.	Approved, Illicit
Quetiapine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.	Approved
Raclopride	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Raclopride.	Investigational
Ramelteon	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.	Approved, Investigational
Rasagiline	Rasagiline may increase the anticholinergic activities of Doxylamine.	Approved
Remifentanil	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.	Approved
Remoxipride	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.	Approved, Withdrawn
Reserpine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Reserpine.	Approved
Risperidone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Risperidone.	Approved, Investigational
Ritanserin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ritanserin.	Investigational
Ritobegron	Ritobegron may decrease the sedative activities of Doxylamine.	Investigational
Romifidine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Romifidine.	Vet Approved
Ropinirole	Doxylamine may increase the sedative activities of Ropinirole.	Approved, Investigational
Ropivacaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.	Approved
Rotigotine	Doxylamine may increase the sedative activities of Rotigotine.	Approved
Rufinamide	The risk or severity of adverse effects can be increased when Rufinamide is combined with Doxylamine.	Approved
Safrazine	Safrazine may increase the anticholinergic activities of Doxylamine.	Withdrawn
Scopolamine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.	Approved
Secobarbital	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.	Approved, Vet Approved
Selegiline	Selegiline may increase the anticholinergic activities of Doxylamine.	Approved, Investigational, Vet Approved
Sepranolone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Uc1010.	Investigational
Sertindole	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Sertindole.	Approved, Withdrawn
Sertraline	The risk or severity of adverse effects can be increased when Doxylamine is combined with Sertraline.	Approved
Sevoflurane	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.	Approved, Vet Approved
Sodium oxybate	Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved
Stiripentol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.	Approved
Sufentanil	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.	Approved, Investigational
Sulpiride	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.	Approved
Suvorexant	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.	Approved
Tandospirone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tandospirone.	Investigational
Tapentadol	Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.	Approved
Tasimelteon	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.	Approved
Temazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Temazepam.	Approved
Tetrabenazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetrabenazine.	Approved
Tetracaine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetracaine.	Approved, Vet Approved
Tetrodotoxin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin.	Investigational
Thalidomide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.	Approved, Investigational, Withdrawn
Thiamylal	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Thiamylal.	Approved, Vet Approved
Thiopental	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Thiopental.	Approved, Vet Approved
Thioridazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.	Withdrawn
Thiothixene	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.	Approved
Tiagabine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.	Approved
Tiapride	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tiapride.	Approved, Investigational
Tiletamine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tiletamine.	Vet Approved
Tizanidine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.	Approved
Tolcapone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.	Approved, Withdrawn
Toloxatone	Toloxatone may increase the anticholinergic activities of Doxylamine.	Approved
Topiramate	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Topiramate.	Approved
Tramadol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.	Approved, Investigational
Trans-2-Phenylcyclopropylamine	Trans-2-Phenylcyclopropylamine may increase the anticholinergic activities of Doxylamine.	Experimental
Tranylcypromine	Tranylcypromine may increase the anticholinergic activities of Doxylamine.	Approved
Trazodone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Trazodone.	Approved, Investigational
Triazolam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Triazolam.	Approved
Trifluoperazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.	Approved
Triflupromazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Triflupromazine.	Approved, Vet Approved
Trimipramine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.	Approved
Triprolidine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.	Approved
Valproic Acid	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Valproic Acid.	Approved, Investigational
Venlafaxine	The risk or severity of adverse effects can be increased when Doxylamine is combined with Venlafaxine.	Approved
Vigabatrin	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.	Approved
Vortioxetine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.	Approved
Xylazine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Xylazine.	Vet Approved
Zaleplon	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.	Approved, Illicit, Investigational
Ziconotide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.	Approved
Zimelidine	The risk or severity of adverse effects can be increased when Doxylamine is combined with Zimelidine.	Withdrawn
Ziprasidone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.	Approved
Zolazepam	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.	Vet Approved
Zolpidem	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.	Approved
Zonisamide	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.	Approved, Investigational
Zopiclone	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.	Approved
Zotepine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zotepine.	Approved
Zuclopenthixol	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.	Approved, Investigational

Food Interactions

Not Available

References

Synthesis Reference

Not Available

General References

Not Available

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB01936
KEGG Drug	D02327
PubChem Compound	3162
PubChem Substance	46506354
ChemSpider	3050
ChEBI	51380
ChEMBL	CHEMBL1004
Therapeutic Targets Database	DAP000859
PharmGKB	PA449419
Drug Product Database	10224
Drugs.com	http://www.drugs.com/cdi/doxylamine.html
Wikipedia	Doxylamine

ATC Codes

R06AA59 — Doxylamine, combinations

R06AA09 — Doxylamine

AHFS Codes

04:04.04

PDB Entries

Not Available

FDA label

Not Available

MSDS

Download (74 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
1	Completed	Not Available	Allergic Rhinitis (AR) / Upper Respiratory Infections	1
3	Completed	Prevention	Hyperemesis Gravidarum / Pregnancy	1
3	Completed	Treatment	Nausea and Vomiting of Pregnancy	1
4	Recruiting	Treatment	Morning Sickness	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Dosage forms

Form	Route	Strength
Capsule, gelatin coated	Oral
Kit
Tablet, effervescent	Oral
Powder, for solution	Oral
Capsule; kit	Oral
Capsule	Oral
Kit	Oral
Tablet, delayed release	Oral
Solution	Oral
Tablet	Oral	25 mg/1
Syrup	Oral
Tablet, coated	Oral
Tablet	Oral
Liquid	Oral
Capsule, liquid filled	Oral
Syrup	Oral	9.75 mg/5mL
Tablet, film coated	Oral
Kit; tablet	Oral
Tablet	Oral	25 mg

Prices

Unit description	Cost	Unit
Doxylamine succinate powder	1.5USD	g
Unisom sleep aid tablet	0.34USD	tablet
Sleep aid 25 mg tablet	0.15USD	tablet

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US6340695	No	2001-06-21	2021-06-21	US
US7560122	No	1999-01-25	2019-01-25	US
US9526703	No	2013-02-18	2033-02-18	US
US9375404	No	2013-02-18	2033-02-18	US
US9089489	No	2013-02-18	2033-02-18	US

Properties

State

Liquid

Experimental Properties

Property	Value	Source
melting point (°C)	< 25 °C	PhysProp
boiling point (°C)	139 °C at 5.00E-01 mm Hg	PhysProp
water solubility	1 g/ml (succinate salt)	Not Available
logP	2.5	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.541 mg/mL	ALOGPS
logP	2.9	ALOGPS
logP	2.96	ChemAxon
logS	-2.7	ALOGPS
pKa (Strongest Basic)	8.87	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	25.36 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	82.24 m³·mol^-1	ChemAxon
Polarizability	31.09 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9505
Blood Brain Barrier	+	0.9491
Caco-2 permeable	+	0.746
P-glycoprotein substrate	Substrate	0.7449
P-glycoprotein inhibitor I	Non-inhibitor	0.5123
P-glycoprotein inhibitor II	Non-inhibitor	0.8383
Renal organic cation transporter	Inhibitor	0.7507
CYP450 2C9 substrate	Non-substrate	0.8153
CYP450 2D6 substrate	Non-substrate	0.5432
CYP450 3A4 substrate	Substrate	0.6801
CYP450 1A2 substrate	Non-inhibitor	0.9092
CYP450 2C9 inhibitor	Non-inhibitor	0.8957
CYP450 2D6 inhibitor	Inhibitor	0.8361
CYP450 2C19 inhibitor	Non-inhibitor	0.8764
CYP450 3A4 inhibitor	Non-inhibitor	0.6894
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.736
Ames test	Non AMES toxic	0.9133
Carcinogenicity	Non-carcinogens	0.9183
Biodegradation	Not ready biodegradable	1.0
Rat acute toxicity	2.9218 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.8765
hERG inhibition (predictor II)	Inhibitor	0.5398

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum Type	Description	Splash Key
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS	Not Available
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0040-0956300000-af11cf85a674e7db3735	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-001i-0910000000-b3cb895f045d519f2bf3	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-00kb-5597500000-8495062a84b32e776f33	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-qTof , Positive	Not Available
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-001i-1920000000-07b98b36c7ef5d9ad048	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-001i-0900000000-1ae1143763892a7aac22	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-001i-0900000000-460d58a5bb6a5eb5f55b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-0159-0900000000-34dc5c06413efae437da	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-014i-0900000000-8a5f15b863b7129c1288	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-014i-0900000000-072ffba5139b7324d27a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-00lr-0900000000-fdf3fc57eff19bfe8fd8	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available
MS	Mass Spectrum (Electron Ionization)	splash10-0ab9-9200000000-5a71de62862f9881c2a1	View in MoNA
1D NMR	1H NMR Spectrum	Not Available
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available

Taxonomy

Description

This compound belongs to the class of organic compounds known as benzylethers. These are aromatic ethers with the general formula ROCR' (R = alkyl, aryl; R'=benzene).

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Benzylethers

Direct Parent

Benzylethers

Alternative Parents

Pyridines and derivatives / Heteroaromatic compounds / Trialkylamines / Dialkyl ethers / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives

Substituents

Benzylether / Pyridine / Heteroaromatic compound / Tertiary amine / Tertiary aliphatic amine / Azacycle / Organoheterocyclic compound / Ether / Dialkyl ether / Amine

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

tertiary amine, pyridines (CHEBI:51380 )

Targets

Details

1. Histamine H1 receptor

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: antagonist

General Function:: Histamine receptor activity
Specific Function:: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:: HRH1
Uniprot ID:: P35367
Uniprot Name:: Histamine H1 receptor
Molecular Weight:: 55783.61 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Details

2. Muscarinic acetylcholine receptor M1

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: antagonist

General Function:: Phosphatidylinositol phospholipase c activity
Specific Function:: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:: CHRM1
Uniprot ID:: P11229
Uniprot Name:: Muscarinic acetylcholine receptor M1
Molecular Weight:: 51420.375 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]

Details

3. Nuclear receptor subfamily 1 group I member 3

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Zinc ion binding
Specific Function:: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Gene Name:: NR1I3
Uniprot ID:: Q14994
Uniprot Name:: Nuclear receptor subfamily 1 group I member 3
Molecular Weight:: 39942.145 Da

References

Dring AM, Anderson LE, Qamar S, Stoner MA: Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands. Chem Biol Interact. 2010 Dec 5;188(3):512-25. doi: 10.1016/j.cbi.2010.09.018. Epub 2010 Oct 20. [PubMed:20869355 ]

Enzymes

Details

1. CYP2B protein

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inducer

General Function:: Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:: Not Available
Gene Name:: CYP2B
Uniprot ID:: Q14097
Uniprot Name:: CYP2B protein
Molecular Weight:: 43147.81 Da

References

Bookstaff RC, Murphy VA, Skare JA, Minnema D, Sanzgiri U, Parkinson A: Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice. Toxicol Appl Pharmacol. 1996 Dec;141(2):584-94. [PubMed:8975784 ]

Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:26

Structure for DB00366 (Doxylamine)

Targets

References

References

References

Enzymes

References