Bortezomib

Identification

Name

Bortezomib

Accession Number

DB00188  (APRD00828, DB07475)

Type

Small Molecule

Groups

Approved, Investigational

Description

Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. It is a reversible inhibitor of the 26S proteasome, which is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway. Inhibition of 26S proteasome leads to cell cycle arrest and apoptosis of cancer cells.¹¹ While inhibition of the 26S proteasome is the main mechanism of action, multiple mechanisms may involved in the therapeutic action of bortezomib.⁵

In May 2003, bortezomib became the first anticancer proteasome inhibitor that was approved by the FDA.⁶ Phase I, II, III, and IV clinical trials are undergoing to investigate the therapeutic efficacy of bortezomib in leukemia, myasthenia gravis, systemic lupus erythematosus, rheumatoid arthritis, and solid tumours.⁷

Structure

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Similar Structures

Structure for Bortezomib (DB00188)

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Synonyms

• [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid
• Bortezomib
• N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

External IDs

BXCL 101 / BXCL-101 / BXCL101 / LDP 341 / LDP-341 / LDP341 / PS 341 / PS-341 / PS341

Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
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Act Bortezomib	Powder, for solution		Intravenous; Subcutaneous	Actavis Pharma Company	2015-11-17	Not applicable
Bortezomib	Powder, for solution	3.5 mg	Intravenous; Subcutaneous	Apotex Corporation	2019-03-25	Not applicable
Bortezomib	Injection, powder, lyophilized, for solution	1 mg/1mL	Intravenous	Fresenius Kabi USA, LLC	2017-11-06	Not applicable
Bortezomib	Injection, powder, lyophilized, for solution	3.5 mg/1	Intravenous	Dr.Reddy's Laboratories Inc	2019-11-01	Not applicable
Bortezomib for Injection	Powder, for solution		Intravenous; Subcutaneous	Pfizer Canada Ulc	Not applicable	Not applicable
Bortezomib for Injection	Powder, for solution		Intravenous; Subcutaneous	Dr Reddy's Laboratories	2017-03-21	Not applicable
Bortezomib for Injection	Powder, for solution		Intravenous; Subcutaneous	Sandoz Canada Incorporated	Not applicable	Not applicable
Bortezomib for Injection	Powder, for solution		Intravenous; Subcutaneous	TEVA Canada Limited	2015-01-06	Not applicable
Bortezomib for Injection	Powder, for solution		Intravenous; Subcutaneous	Mda Inc.	Not applicable	Not applicable
Bortezomib for Injection	Powder, for solution		Intravenous	Mda Inc.	Not applicable	Not applicable

Additional Data Available

Application Number
Application Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
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Product Code
Product Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
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Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Unlock Additional Data
Bortezomib Accord	Injection, powder, for solution	3.5 mg	Intravenous; Subcutaneous	Accord Healthcare Limited	2015-07-20	Not applicable
Bortezomib Hospira	Injection, powder, for solution	3.5 mg	Intravenous; Subcutaneous	Hospira, Inc.	2016-07-22	Not applicable
Bortezomib Sun	Injection, powder, for solution	3.5 mg	Intravenous; Subcutaneous	Sun Pharmaceutical Industries (Europe) B.V.	2016-07-22	Not applicable
PMS-bortezomib	Powder, for solution		Intravenous; Subcutaneous	Pharmascience Inc	2018-06-05	Not applicable
Taro-bortezomib	Powder, for solution		Intravenous; Subcutaneous	Taro Pharmaceuticals, Inc.	Not applicable	Not applicable

Additional Data Available

Application Number
Application Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
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Product Code
Product Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
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Categories

• Acids
• Acids, Noncarboxylic
• Antineoplastic Agents
• Antineoplastic and Immunomodulating Agents
• Boron Compounds
• Boronic Acids
• Cardiotoxic antineoplastic agents
• Cytochrome P-450 CYP1A2 Inhibitors
• Cytochrome P-450 CYP1A2 Inhibitors (moderate)
• Cytochrome P-450 CYP1A2 Inhibitors (strength unknown)
• Cytochrome P-450 CYP1A2 Substrates
• Cytochrome P-450 CYP2C19 Inhibitors
• Cytochrome P-450 CYP2C19 Inhibitors (weak)
• Cytochrome P-450 CYP2C19 Substrates
• Cytochrome P-450 CYP2C9 Inhibitors
• Cytochrome P-450 CYP2C9 Inhibitors (strength unknown)
• Cytochrome P-450 CYP2C9 Substrates
• Cytochrome P-450 CYP2D6 Substrates
• Cytochrome P-450 CYP3A Substrates
• Cytochrome P-450 CYP3A4 Substrates
• Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
• Cytochrome P-450 Enzyme Inhibitors
• Cytochrome P-450 Substrates
• Hepatotoxic Agents
• Hypotensive Agents
• Immunosuppressive Agents
• Myelosuppressive Agents
• Narrow Therapeutic Index Drugs
• OATP1B3 inhibitors
• P-glycoprotein substrates
• P-glycoprotein substrates with narrow therapeutic index
• Potential QTc-Prolonging Agents
• Proteasome Inhibitors
• Pyrazines
• QTc Prolonging Agents

UNII

69G8BD63PP

CAS number

179324-69-7

Weight

Average: 384.237
Monoisotopic: 384.196885774

Chemical Formula

C₁₉H₂₅BN₄O₄

InChI Key

GXJABQQUPOEUTA-RDJZCZTQSA-N

InChI

InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

IUPAC Name

[(1R)-3-methyl-1-[(2S)-3-phenyl-2-(pyrazin-2-ylformamido)propanamido]butyl]boronic acid

SMILES

CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=CN=CC=N1)B(O)O

Pharmacology

Indication

Bortezomib is indicated for the treatment of adult patients with multiple myeloma or mantle cell lymphoma.⁸

Associated Conditions

• Mantle Cell Lymphoma (MCL)
• Multiple Myeloma (MM)

Pharmacodynamics

Bortezomib works to target the ubiquitin-proteasome pathway, an essential molecular pathway that promotes protein degradation and maintains the homeostatic intracellular concentrations of proteins.¹ However, there is strong evidence in the literature that the ubiquitin-proteasome pathway is often dysregulated, leading to aberrant pathway signalling. In one study, patient-derived chronic lymphocytic leukemia (CLL) cells contained 3-fold higher levels of chymotrypsin-like proteasome activity than normal lymphocytes, indicating that dysregulation of the ubiquitin-proteasome pathway is implicated in malignant cell transformation.¹ By reversibly inhibiting an enzyme involved in the ubiquitin-proteasome pathway, bortezomib prevents the proteasome-mediated proteolysis. Bortezomib exerts a cytotoxic effect on various cancer cell types in vitro. In non-clinical tumour models, including multiple myeloma, bortezomib caused a delay in tumour growth.⁸

Mechanism of action

Bortezomib is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins. The active site of the proteasome has chymotrypsin-like, trypsin-like, and postglutamyl peptide hydrolysis activity. The 26S proteasome degrades various proteins critical to cancer cell survival, such as cyclins, tumor suppressors, BCL-2, and cyclin-dependent kinase inhibitors. Inhibition of these degradations sensitizes cells to apoptosis. Bortezomib is a potent inhibitor of 26S proteasome, which sensitizes activity in dividing multiple myeloma and leukemic cells, thus inducing apoptosis. In addition, bortezomib appears to increase the sensitivity of cancer cells to traditional anticancer agents (e.g., gemcitabine, cisplatin, paclitaxel, irinotecan, and radiation).

Target	Actions	Organism
AProteasome subunit beta type-5	inhibitor	Humans
AProteasome subunit beta type-1	inhibitor	Humans

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Additional Data Available

Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Blackbox Warnings

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Absorption

Following intravenous administration of 1 mg/m² and 1.3 mg/m² doses, the mean C_max of bortezomib were 57 and 112 ng/mL, respectively. In a twice-weekly dosing regimen, the C_max ranged from 67 to 106 ng/mL at the dose of 1 mg/m² and 89 to 120 ng/mL for the 1.3 mg/m² dose. In patients with multiple myeloma, the C_max of bortezomib followig subcutaneous administration was lower than that of intravenously-administered dose; however, the total systemic exposure of the drug was equivalent for both routes of administration.⁸ There is a wide interpatient variability in plasma concentrations.¹¹

Volume of distribution

The mean distribution volume of bortezomib ranged from approximately 498 to 1884 L/m² in patients with multiple myeloma receiving a single- or repeat-dose of 1 mg/m² or 1.3 mg/m².⁸

Protein binding

Over the concentration range of 100 to 1000 ng/mL, bortezomib is about 83% bound to human plasma proteins.⁸

Metabolism

Bortezomib is primarily metabolized by CYP3A4, CYP2C19, and CYP1A2. CYP2D6 and CYP2C9 are also involved in drug metabolism, but to a smaller extent.⁸ Oxidative deboronation, which involves the removal of boronic acid from the parent compound, is main metabolic pathway. Metabolites of bortezomib are pharmacologically inactive and more than 30 metabolites have been identified in human and animal studies.⁶

• Bortezomib
  Bortezomib metabolite M1
  • Bortezomib metabolite M1
    Bortezomib metabolite M3
    • Bortezomib metabolite M3
      Bortezomib metabolite M4
  • Bortezomib metabolite M1
    Bortezomib metabolite M5
  • Bortezomib metabolite M1
    Bortezomib metabolite M25
  • Bortezomib metabolite M1
    Bortezomib metabolite M26
• Bortezomib
  Bortezomib metabolite M2
  • Bortezomib metabolite M2
    Bortezomib metabolite M3
  • Bortezomib metabolite M2
    Bortezomib metabolite M6
  • Bortezomib metabolite M2
    Bortezomib metabolite M8
    • Bortezomib metabolite M8
      Bortezomib metabolite M33
  • Bortezomib metabolite M2
    Bortezomib metabolite M27
  • Bortezomib metabolite M2
    Bortezomib metabolite M28
• Bortezomib
  Bortezomib metabolite M34
• Bortezomib
  Bortezomib metabolite M23 or M24 (1)
• Bortezomib
  Bortezomib metabolite M23 or M24 (2)

Route of elimination

Bortezomib is eliminated by both renal and hepatic routes.⁶

Half life

The mean elimination half-life of bortezomib ranged from 40 to 193 hours following a multiple dosing regimen at a 1 mg/m² dose. The half-life ranged from 76 to 108 hours after multiple dosing of 1.3 mg/m² bortezomib.⁸

Clearance

Following the administration of a first dose of 1 mg/m² and 1.3 mg/m², the mean mean total body clearances were 102 and 112 L/h, respectively. The clearances were 15 and 32 L/h after the subsequent dose of 1 and 1.3 mg/m², respectively.⁸

Toxicity

The Lowest published toxic dose (TD_Lo) in mouse was 5 mg/kg/14D following intraperitoneal administration of an intermittent dose and 1.6 mg/kg/12D following subcutaneous administration of a continuous dose.¹⁰

The therapeutic dose of bortezomib is individualized in each patient to prevent overdose. Fatal outcomes occurred in humans following the administration of more than twice the recommended therapeutic dose of bortezomib. The symptoms from overdose included the acute onset of symptomatic hypotension and thrombocytopenia. As there is no known antidote for bortezomib overdosage, monitoring of vital signs and appropriate supportive care should be initiated when drug overdosage is suspected. In monkeys and dogs, increased heart rate, decreased contractility, hypotension, and death were observed with the intravenous dose as low as two times the recommended clinical dose on a mg/m2 basis. A case of a slight increase in the corrected QT interval leading to death occurred in dog studies.⁸

Affected organisms

• Humans and other mammals

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• All Drugs
• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental

Drug	Interaction
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(R)-warfarin	The metabolism of (R)-warfarin can be decreased when combined with Bortezomib.
(S)-Warfarin	The metabolism of (S)-Warfarin can be decreased when combined with Bortezomib.
1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine	The metabolism of Bortezomib can be decreased when combined with 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine.
2-Methoxyethanol	The risk or severity of adverse effects can be increased when Bortezomib is combined with 2-Methoxyethanol.
4-hydroxycoumarin	The risk or severity of bleeding can be increased when 4-hydroxycoumarin is combined with Bortezomib.
4-Methoxyamphetamine	The metabolism of 4-Methoxyamphetamine can be decreased when combined with Bortezomib.
5-methoxy-N,N-dimethyltryptamine	The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Bortezomib.
6-Deoxyerythronolide B	The metabolism of Bortezomib can be decreased when combined with 6-Deoxyerythronolide B.
6-O-benzylguanine	The metabolism of 6-O-benzylguanine can be decreased when combined with Bortezomib.
7-ethyl-10-hydroxycamptothecin	The metabolism of Bortezomib can be decreased when combined with 7-ethyl-10-hydroxycamptothecin.

Additional Data Available

Extended Description
Extended Description
Extended description of the mechanism of action and particular properties of each drug interaction.
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Severity
Severity
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Evidence Level
Evidence Level
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Action
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Food Interactions

• Avoid St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce the serum concentration of bortezomib.
• Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of bortezomib.
• Limit foods and supplements high in flavonoids. Flavonoids may interfere with the therapeutic action of this drug. Foods high in flavonoids include green vegetables, fruits, and green tea.
• Limit foods and supplements high in vitamin C. Vitamin C may interfere with the therapeutic action of this drug. Foods high in vitamin C include citrus fruits and beverages.

References

Synthesis Reference

Raghavendracharyulu Venkata Palle, Rajasekhar Kadaboina, Veerendeer Murki, Amarendhar Manda, Nageshwar Gunda, Ramaseshagiri Rao Pulla, Mallesha Hanmanthu, Narasimha Naidu Mopidevi, Suresh Kumar Ramdoss, "BORTEZOMIB AND PROCESS FOR PRODUCING SAME." U.S. Patent US20100226597, issued September 09, 2010.

US20100226597

General References

1. Voorhees PM, Dees EC, O'Neil B, Orlowski RZ: The proteasome as a target for cancer therapy. Clin Cancer Res. 2003 Dec 15;9(17):6316-25. [PubMed:14695130]
2. Oakervee HE, Popat R, Curry N, Smith P, Morris C, Drake M, Agrawal S, Stec J, Schenkein D, Esseltine DL, Cavenagh JD: PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma. Br J Haematol. 2005 Jun;129(6):755-62. [PubMed:15953001]
3. Adams J, Palombella VJ, Sausville EA, Johnson J, Destree A, Lazarus DD, Maas J, Pien CS, Prakash S, Elliott PJ: Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22. [PubMed:10363983]
4. Berkers CR, Verdoes M, Lichtman E, Fiebiger E, Kessler BM, Anderson KC, Ploegh HL, Ovaa H, Galardy PJ: Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat Methods. 2005 May;2(5):357-62. Epub 2005 Apr 21. [PubMed:15846363]
5. Chen D, Frezza M, Schmitt S, Kanwar J, Dou QP: Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives. Curr Cancer Drug Targets. 2011 Mar;11(3):239-53. doi: 10.2174/156800911794519752. [PubMed:21247388]
6. Schwartz R, Davidson T: Pharmacology, pharmacokinetics, and practical applications of bortezomib. Oncology (Williston Park). 2004 Dec;18(14 Suppl 11):14-21. [PubMed:15688598]
7. Guedes RA, Aniceto N, Andrade MAP, Salvador JAR, Guedes RC: Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design. Int J Mol Sci. 2019 Oct 25;20(21). pii: ijms20215326. doi: 10.3390/ijms20215326. [PubMed:31731563]
8. FDA Approved Drug Products: Bortezomib for Injection, for subcutaneous or intravenous use [Link]
9. Thermo Fisher Scientific: Bortezomib Safety Data Sheet [Link]
10. Cayman Chemical: Bortezomib Safety Data Sheet [Link]
11. BC Cancer: Bortezomib Monograph [Link]

External Links

Human Metabolome Database

HMDB0014334

KEGG Drug

D03150

PubChem Compound

387447

PubChem Substance

46508736

ChemSpider

343402

BindingDB

50069989

RxNav

358258

ChEBI

52717

ChEMBL

CHEMBL325041

ZINC

ZINC000169746649

Therapeutic Targets Database

DAP001318

PharmGKB

PA10252

PDBe Ligand

BO2

RxList

RxList Drug Page

Drugs.com

Drugs.com Drug Page

Wikipedia

Bortezomib

ATC Codes

L01XX32 — Bortezomib

• L01XX — Other antineoplastic agents
• L01X — OTHER ANTINEOPLASTIC AGENTS
• L01 — ANTINEOPLASTIC AGENTS
• L — ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

AHFS Codes

• 10:00.00 — Antineoplastic Agents

PDB Entries

2f16 / 3mg0 / 4fwd / 4qvl / 4qvm / 4qvn / 4qvp / 4qvq / 4qvv / 4qvw …

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FDA label

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Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Active Not Recruiting	Basic Science	Multiple Myeloma (MM)	1
0	Completed	Treatment	Autologous Transplant / Malignant Lymphoma, Stem Cell Type	1
0	Completed	Treatment	Chronic Myeloproliferative Disorders / Leukemias	1
0	Completed	Treatment	Multiple Myeloma (MM)	1
0	Not Yet Recruiting	Health Services Research	Breast Cancer	1
0	Terminated	Treatment	Lymphoma, B-Cell	1
0	Terminated	Treatment	Multiple Myeloma (MM)	1
1	Active Not Recruiting	Treatment	Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome	1
1	Active Not Recruiting	Treatment	Acute Myeloid Leukemia (AML) / Recurrent Adult Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Therapy-Related Acute Myeloid Leukemia	1
1	Active Not Recruiting	Treatment	Autologous Hematopoietic Stem Cell Transplant Recipient / Leukemia, Plasma Cell / Loss of Chromosome 17p / Recurrent Plasma Cell Myeloma / Refractory Multiple Myeloma / Refractory Plasma Cell Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma	1
1	Active Not Recruiting	Treatment	Graft Versus Host Disease (GVHD)	1
1	Active Not Recruiting	Treatment	Leukemias	1
1	Active Not Recruiting	Treatment	Light Chain Deposition Disease / Primary Systemic Amyloidosis	1
1	Active Not Recruiting	Treatment	Multiple Myeloma (MM)	2
1	Active Not Recruiting	Treatment	Multiple Myeloma in Relapse	1
1	Active Not Recruiting	Treatment	Plasma Cell Myeloma	1
1	Active Not Recruiting	Treatment	Recurrent B-Cell Non-Hodgkin Lymphoma / Recurrent Mantle Cell Lymphoma / Refractory B-Cell Non-Hodgkin Lymphoma / Refractory Mantle Cell Lymphoma	1
1	Active Not Recruiting	Treatment	Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma	1
1	Active Not Recruiting	Treatment	Tumors, Solid / Urethral Cancer	1
1	Completed	Basic Science	Adult Grade III Lymphomatoid Granulomatosis / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Nodal marginal zone B-cell lymphomas / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Refractory Multiple Myeloma / Splenic Marginal Zone Lymphoma / Stage III Multiple Myeloma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Small Lymphocytic Lymphoma / Unspecified Adult Solid Tumor, Protocol Specific / Waldenström's Macroglobulinemia (WM)	1
1	Completed	Other	Multiple Myeloma (MM)	1
1	Completed	Other	Non-Small Cell Lung Carcinoma (NSCLC)	1
1	Completed	Prevention	Hematopoetic Stem Cell Transplant	1
1	Completed	Treatment	Acute Lymphocytic Leukemia (ALL) / Acute Myeloid Leukemia (AML) / Chronic Chronic myelogenous leukemia / Myelodysplastic Syndrome	1
1	Completed	Treatment	Acute Myeloid Leukemia (AML)	1
1	Completed	Treatment	Acute Myeloid Leukemia (AML) / Acute Myeloid Leukemia With Multilineage Dysplasia Following / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Myelodysplastic Syndrome / Recurrent Adult Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML)	1
1	Completed	Treatment	Adult Acute Basophilic Leukemia / Adult Acute Eosinophilic Leukemia / Adult Acute Megakaryoblastic Leukemia / Adult Acute Monoblastic Leukemia / Adult Acute Monocytic Leukemia / Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 / Adult Acute Myeloid Leukemia With Maturation / Adult Acute Myeloid Leukemia With Minimal Differentiation / Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11 / Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1 / Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL / Adult Acute Myeloid Leukemia Without Maturation / Adult Acute Myelomonocytic Leukemia / Adult Erythroleukemia / Adult Pure Erythroid Leukemia / Blastic Phase / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Disease / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Myeloid Leukemia	1
1	Completed	Treatment	Adult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Acute Myelomonocytic Leukemia (M4) / Adult Erythroleukemia (M6a) / Adult Pure Erythroid Leukemia (M6b) / Recurrent Adult Acute Myeloid Leukemia	1
1	Completed	Treatment	Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Recurrent Adult Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Untreated Adult Acute Myeloid Leukemia	1
1	Completed	Treatment	Adult Acute Promyelocytic Leukemia (M3) / Blastic Phase Chronic Myelogenous Leukemia / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Excess Blasts in Transformation / Relapsing Chronic Myelogenous Leukemia	1
1	Completed	Treatment	Adult Grade III Lymphomatoid Granulomatosis / Anaplastic Large Cell Lymphoma / Anaplastic Large-Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Post Transplant Lymphoproliferative Disorder / Primary Central Nervous System Hodgkin Lymphoma / Primary Central Nervous System Non-Hodgkin Lymphoma / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Splenic Marginal Zone Lymphoma / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Mycosis Fungoides/Sezary Syndrome / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Mycosis Fungoides/Sezary Syndrome / Stage IV Small Lymphocytic Lymphoma / Unspecified Adult Solid Tumor, Protocol Specific / Waldenström's Macroglobulinemia (WM)	1
1	Completed	Treatment	Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Anaplastic Large-Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Hepatosplenic T-Cell Lymphoma / Leukemia, Prolymphocytic / Peripheral T-Cell Lymphoma (PTCL) / Post Transplant Lymphoproliferative Disorder / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Small Intestine Lymphoma / T-Cell Large Granular Lymphocyte Leukemia	1
1	Completed	Treatment	Advanced Cancer, Various, NOS	1
1	Completed	Treatment	Advanced Malignancy / Malignant Lymphomas / Plasma Cell Myeloma / Tumors, Solid	1
1	Completed	Treatment	Advanced or Metastatic Solid Tumors	1
1	Completed	Treatment	Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Promyelocytic Leukemia (M3) / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia	1
1	Completed	Treatment	Brain Cancer / Central Nervous System Neoplasms / Cervix Cancer / Head and Neck Carcinoma	1
1	Completed	Treatment	Brain and Central Nervous System Tumors / Malignant Lymphomas / Metastatic Cancers / Unspecified Adult Solid Tumor, Protocol Specific	1
1	Completed	Treatment	Breast Cancer / Colorectal Cancers / Head and Neck Carcinoma / Lung Cancers / Malignant Melanoma of Skin / Malignant Neoplasm of Pancreas / Melanoma (Skin) / Ovarian Cancer / Prostate Cancer / Unspecified Adult Solid Tumor, Protocol Specific	1
1	Completed	Treatment	Breast Cancer / Colorectal Cancers / Head and Neck Carcinoma / Lung Cancers / Malignant Neoplasm of Pancreas / Ovarian Cancer / Prostate Cancer / Renal Cancers / Sarcomas	1
1	Completed	Treatment	Breast Cancer / Colorectal Cancers / Head and Neck Carcinoma / Lung Cancers / Malignant Neoplasm of Pancreas / Renal Cancers / Sarcomas / Unspecified Adult Solid Tumor, Protocol Specific	1
1	Completed	Treatment	Cancer, Advanced	2
1	Completed	Treatment	Carcinoid Tumors / Melanoma / Parathyroid Carcinoma / Small Cell Lung Cancer (SCLC) / Soft Tissue Sarcoma (STS)	1
1	Completed	Treatment	Carcinoma Breast Stage IV	1
1	Completed	Treatment	Childhood Burkitt Lymphoma / Childhood Central Nervous System Choriocarcinoma / Childhood Central Nervous System Germ Cell Tumor / Childhood Central Nervous System Germinoma / Childhood Central Nervous System Mixed Germ Cell Tumor / Childhood Central Nervous System Teratoma / Childhood Central Nervous System Yolk Sac Tumor / Childhood Choroid Plexus Tumor / Childhood Craniopharyngioma / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Childhood Medulloepithelioma / Childhood Meningioma / Childhood Mixed Glioma / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Childhood Oligodendroglioma / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Brain Stem Glioma / Recurrent Childhood Central Nervous System Embryonal Tumor / Recurrent Childhood Cerebellar Astrocytoma / Recurrent Childhood Cerebral Astrocytoma / Recurrent Childhood Ependymoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Malignant Germ Cell Tumor / Recurrent Childhood Medulloblastoma / Recurrent Childhood Pineoblastoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Childhood Subependymal Giant Cell Astrocytoma / Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor / Recurrent Childhood Visual Pathway and Hypothalamic Glioma / Recurrent Childhood Visual Pathway Glioma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Unspecified Childhood Solid Tumor, Protocol Specific	1
1	Completed	Treatment	Chronic Lymphocytic Leukaemia (CLL) / Indolent Non-Hodgkin's Lymphomas / Mantle Cell Lymphoma (MCL)	1
1	Completed	Treatment	Chronic Lymphocytic Leukemia (CLL) - Refractory / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hematopoietic/Lymphoid Cancer / Nodal marginal zone B-cell lymphomas / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Splenic Marginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)	1
1	Completed	Treatment	Chronic Lymphocytic Leukemia (CLL) - Refractory / Refractory Multiple Myeloma / Stage III Multiple Myeloma / Stage IV Chronic Lymphocytic Leukemia / Unspecified Adult Solid Tumor, Protocol Specific	1
1	Completed	Treatment	Colorectal Cancers	2
1	Completed	Treatment	DS Stage I Plasma Cell Myeloma / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma / Refractory Plasma Cell Myeloma	1
1	Completed	Treatment	Diffuse Large B-Cell Lymphoma (DLBCL)	1
1	Completed	Treatment	Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue / Nodal Marginal Zone Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Refractory Plasma Cell Myeloma / Splenic Marginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)	1
1	Completed	Treatment	Fallopian Tube Cancer / Ovarian Cancer / Primary Peritoneal Cancer	1
1	Completed	Treatment	Fallopian Tube Cancer / Ovarian Cancer / Primary Peritoneal Cavity Cancer	1
1	Completed	Treatment	Fallopian Tube Clear Cell Adenocarcinoma / Fallopian Tube Endometrioid Adenocarcinoma / Fallopian Tube Mucinous Adenocarcinoma / Fallopian Tube Serous Adenocarcinoma / Fallopian Tube Transitional Cell Carcinoma / Malignant Ovarian Mixed Epithelial Tumor / Ovarian Brenner Tumor / Ovarian Clear Cell Adenocarcinoma / Ovarian Clear Cell Cystadenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mucinous Adenocarcinoma / Ovarian Mucinous Cystadenocarcinoma / Ovarian Seromucinous Carcinoma / Ovarian Serous Adenocarcinoma / Ovarian Serous Cystadenocarcinoma / Ovarian Transitional Cell Carcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Undifferentiated Fallopian Tube Carcinoma / Undifferentiated Ovarian Carcinoma	1
1	Completed	Treatment	Glioblastoma Multiforme (GBM)	1
1	Completed	Treatment	Graft Versus Host Disease (GVHD) / Peripheral Blood Stem Cell Transplantation / Transplantation, Homologous	1
1	Completed	Treatment	Head and Neck Carcinoma	1
1	Completed	Treatment	Carcinoma squamous / Head and Neck Carcinoma / Laryngeal Cancer / Oral Cancers / Pharyngeal Cancer / Squamous Carcinoma	1
1	Completed	Treatment	Hepatic Complications / Neoplasms, Malignant	1
1	Completed	Treatment	Human Immunodeficiency Virus (HIV) Infections / Kaposi's Sarcoma AIDS Related / Recurrent Kaposi's Sarcoma	1
1	Completed	Treatment	Leukemias	1
1	Completed	Treatment	Leukemias / Malignant Lymphomas	1
1	Completed	Treatment	Leukemias / Malignant Lymphomas / Mature T-cell and Nk-cell Neoplasms / Multiple Myeloma and Plasma Cell Neoplasm	1
1	Completed	Treatment	Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes (MDS)	1
1	Completed	Treatment	Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Precancerous Conditions / Unspecified Adult Solid Tumor, Protocol Specific	1
1	Completed	Treatment	Leukemias / Myelodysplastic Syndromes (MDS) / Myelodysplastic/Myeloproliferative Neoplasms	1
1	Completed	Treatment	Lung Cancers / Unspecified Adult Solid Tumor, Protocol Specific	1
1	Completed	Treatment	Lymphoma, Hodgkins / Malignant Lymphomas	1
1	Completed	Treatment	Malignancies, Hematologic	1
1	Completed	Treatment	Malignant Lymphomas	2
1	Completed	Treatment	Malignant Lymphomas / Neuroblastomas / Sarcomas / WilmsTumor	1
1	Completed	Treatment	Malignant Lymphomas / Small Intestine Cancer / Unspecified Adult Solid Tumor, Protocol Specific	1
1	Completed	Treatment	Malignant Pleural Effusions / Non-Small Cell Lung Cancer Recurrent / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer	1
1	Completed	Treatment	Mantle Cell Lymphoma (MCL)	1
1	Completed	Treatment	Melanoma	2
1	Completed	Treatment	Multiple Myeloma (MM)	19
1	Completed	Treatment	Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL)	1
1	Completed	Treatment	Multiple Myeloma (MM) / Refractory Multiple Myeloma / Relapsed Multiple Myeloma	1
1	Completed	Treatment	Multiple Myeloma and Plasma Cell Neoplasm	4
1	Completed	Treatment	Multiple Myeloma, Plasma Cell Leukemia	1
1	Completed	Treatment	Myelodysplasia	1
1	Completed	Treatment	Neuroblastomas	1
1	Completed	Treatment	Non-Hodgkin's Lymphoma (NHL)	1
1	Completed	Treatment	Non-Hodgkin's Lymphoma (NHL) / Tumors	1
1	Completed	Treatment	Plasma Cell Myeloma	1
1	Completed	Treatment	Prostate Cancer	1
1	Completed	Treatment	Recurrent Plasma Cell Myeloma	1
1	Completed	Treatment	Refractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	1
1	Completed	Treatment	Relapsed/Refractory Multiple Myeloma	1
1	Completed	Treatment	Squamous Cell Carcinoma (SCC)	1
1	Completed	Treatment	Tumors	1
1	Completed	Treatment	Tumors, Solid	2
1	Completed	Treatment	Unspecified Adult Solid Tumor, Protocol Specific	9
1	Completed	Treatment	Unspecified Childhood Solid Tumor, Protocol Specific	1
1	Not Yet Recruiting	Other	Relapsed and/or Refractory Multiple Myeloma	1
1	Recruiting	Basic Science	Soft Tissue Sarcoma Adult	1
1	Recruiting	Treatment	Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Acute Lymphoblastic Leukaemia Recurrent / Acute, recurrent Myeloid Leukemia / Anatomic Stage IV Breast Cancer AJCC v8 / Anemia / Ann Arbor Stage III Hodgkin Lymphoma / Ann Arbor Stage III Non-Hodgkin Lymphoma / Ann Arbor Stage IIIA Hodgkin Lymphoma / Ann Arbor Stage IIIB Hodgkin Lymphoma / Ann Arbor Stage IV Hodgkin Lymphoma / Ann Arbor Stage IV Non-Hodgkin Lymphoma / Ann Arbor Stage IVA Hodgkin Lymphoma / Ann Arbor Stage IVB Hodgkin Lymphoma / Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Castration-Resistant Prostate Carcinoma / Chronic Lymphocytic Leukemia (CLL) - Refractory / Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Chronic, recurrent Lymphocytic Leukemia / Hematopoietic and Lymphoid Cell Neoplasm / Locally Advanced Pancreatic Adenocarcinoma / Metastatic Breast Carcinoma / Metastatic Malignant Solid Neoplasm / Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Pancreatic Adenocarcinoma Metastatic / Primary Myelofibrosis / Prognostic Stage IV Breast Cancer AJCC v8 / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Recurrent Hematologic Malignancy / Recurrent Hodgkin Lymphoma / Recurrent Myelodysplastic Syndrome / Recurrent Myelodysplastic/Myeloproliferative Neoplasm / Recurrent Myeloproliferative Neoplasm / Recurrent Non-Hodgkin Lymphoma / Recurrent Plasma Cell Myeloma / Recurrent Small Lymphocytic Lymphoma / Refractory Acute Lymphoblastic Leukemia / Refractory Acute Myelogenous Leukemia (AML) / Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Refractory Chronic Myelomonocytic Leukemia / Refractory Hematologic Malignancy / Refractory Hodgkin Lymphoma / Refractory Malignant Solid Neoplasm / Refractory Myelodysplastic Syndrome / Refractory Myelodysplastic/Myeloproliferative Neoplasm / Refractory Non-Hodgkin's lymphoma / Refractory Plasma Cell Myeloma / Refractory Primary Myelofibrosis / Refractory Small Lymphocytic Lymphoma / Stage II Pancreatic Cancer AJCC v8 / Stage IIA Pancreatic Cancer AJCC v8 / Stage IIB Pancreatic Cancer AJCC v8 / Stage III Pancreatic Cancer AJCC v8 / Stage IV Pancreatic Cancer AJCC v8 / Stage IV Prostate Cancer AJCC v8 / Stage IVA Prostate Cancer AJCC v8 / Stage IVB Prostate Cancer AJCC v8 / Unresectable Pancreatic Adenocarcinoma	1
1	Recruiting	Treatment	Acute Lymphoblastic Leukemia With Failed Remission / Acute Lymphoblastic Leukemia, in Relapse	1
1	Recruiting	Treatment	Carcinoma, Non-Small -Cell Lung / Chronic Myeloid Leukemia (CML) / Colon/ Rectal Ca / Multiple Myeloma (MM) / Non-Small Cell Lung Carcinoma (NSCLC) / Pancreatic Ca	1
1	Recruiting	Treatment	Dysferlinopathy	1
1	Recruiting	Treatment	Malignant Lymphomas / Myelodysplastic Syndromes (MDS) / Neoplasms	1
1	Recruiting	Treatment	Malignant Lymphomas / Relapsed/Refractory T-cell Lymphomas	1
1	Recruiting	Treatment	Multiple Myeloma (MM)	2
1	Recruiting	Treatment	Multiple Myeloma (MM) / Novel Coronavirus Infectious Disease (COVID-19)	1
1	Recruiting	Treatment	Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma	1
1	Suspended	Treatment	Lymphoma, Hodgkins / Non-Hodgkin's Lymphoma (NHL)	1
1	Terminated	Treatment	714leukemia / Malignant Lymphomas	1
1	Terminated	Treatment	Adult Grade III Lymphomatoid Granulomatosis / AIDS-related Peripheral/Systemic Lymphoma / Anaplastic Large Cell Lymphoma / Anaplastic Large-Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Nodal marginal zone B-cell lymphomas / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Mycosis Fungoides/Sezary Syndrome / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Mycosis Fungoides/Sezary Syndrome / Stage IV Small Lymphocytic Lymphoma / Unspecified Adult Solid Tumor, Protocol Specific / Waldenström's Macroglobulinemia (WM)	1
1	Terminated	Treatment	Adult Acute Basophilic Leukemia / Adult Acute Eosinophilic Leukemia / Adult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Acute Myelomonocytic Leukemia (M4) / Adult Erythroleukemia (M6a) / Adult Pure Erythroid Leukemia (M6b) / Anaplastic Large Cell Lymphoma / Anaplastic Large-Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Chronic Lymphocytic Leukemia (CLL) - Refractory / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Nodal marginal zone B-cell lymphomas / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)	1
1	Terminated	Treatment	Adult Anaplastic Astrocytoma / Adult Anaplastic Oligodendroglioma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Recurrent Adult Brain Tumor	1
1	Terminated	Treatment	Adult Non-Hodgkin's Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma	1
1	Terminated	Treatment	Advanced Non Small Cell Lung Cancer / Other Solid Tumors	1
1	Terminated	Treatment	Advanced Solid Tumors	1
1	Terminated	Treatment	Disorders, Lymphoproliferative / Malignant Lymphomas	1
1	Terminated	Treatment	Lung Cancers	1
1	Terminated	Treatment	Lymphoma, B-Cell / Non-Hodgkin's Lymphoma (NHL)	1
1	Terminated	Treatment	Mantle Cell Lymphoma (MCL)	1
1	Terminated	Treatment	Multiple Myeloma (MM)	4
1	Terminated	Treatment	Multiple Myeloma and Plasma Cell Neoplasm	1
1	Terminated	Treatment	Myelodysplastic Syndrome	1
1	Terminated	Treatment	Non-Small Cell Lung Carcinoma (NSCLC)	1
1	Terminated	Treatment	Refractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	1
1	Terminated	Treatment	Unspecified Adult Solid Tumor, Protocol Specific	1
1	Unknown Status	Treatment	Multiple Myeloma (MM)	1
1	Unknown Status	Treatment	Refractory Autoimmune Cytopenia(s)	1
1	Withdrawn	Treatment	Leukemia, Plasma Cell	1
1	Withdrawn	Treatment	Multiple Myeloma (MM)	1
1	Withdrawn	Treatment	Multiple Myeloma (MM) / Multiple Myeloma in Relapse / Refractory Multiple Myeloma	1
1	Withdrawn	Treatment	Multiple Myeloma and Plasma Cell Neoplasm	1
1, 2	Active Not Recruiting	Prevention	Haematological Malignancies	1
1, 2	Active Not Recruiting	Treatment	DS Stage I Plasma Cell Myeloma / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma	1
1, 2	Active Not Recruiting	Treatment	Malignant Lymphomas	1
1, 2	Active Not Recruiting	Treatment	Mantle Cell Lymphoma (MCL)	3
1, 2	Active Not Recruiting	Treatment	Multiple Myeloma (MM)	4
1, 2	Active Not Recruiting	Treatment	Neurotoxicity Syndrome / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Waldenström's Macroglobulinemia (WM)	1
1, 2	Active Not Recruiting	Treatment	Recurrent Neuroblastoma	1
1, 2	Active Not Recruiting	Treatment	Renal Cell Adenocarcinoma	1
1, 2	Active Not Recruiting	Treatment	Waldenström's Macroglobulinemia (WM)	1
1, 2	Completed	Prevention	Malignancies, Hematologic	1
1, 2	Completed	Treatment	Acute Lymphoblastic Leukaemias (ALL)	1
1, 2	Completed	Treatment	Acute Myeloid Leukemia (AML)	2
1, 2	Completed	Treatment	Acute Myeloid Leukemia (AML) / Adult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Acute Myelomonocytic Leukemia (M4) / Adult Erythroleukemia (M6a) / Adult Pure Erythroid Leukemia (M6b) / Untreated Adult Acute Myeloid Leukemia	1
1, 2	Completed	Treatment	Adult T-cell lymphomas/leukaemias	1
1, 2	Completed	Treatment	Amyloidosis	1
1, 2	Completed	Treatment	Breast Cancer / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Ovarian Cancer / Unspecified Adult Solid Tumor, Protocol Specific	1
1, 2	Completed	Treatment	Follicular Lymphoma (FL) / Lymphoma, B-Cell	1
1, 2	Completed	Treatment	Kidney Transplant Rejection	1
1, 2	Completed	Treatment	Leukemias / Malignant Lymphomas	1
1, 2	Completed	Treatment	Lung Cancers / Unspecified Adult Solid Tumor, Protocol Specific	1
1, 2	Completed	Treatment	Lymphoma, B-Cell / Lymphoma, Large-Cell, Diffuse	1
1, 2	Completed	Treatment	Malignancies, Hematologic / Multiple Myeloma (MM)	1
1, 2	Completed	Treatment	Mantle Cell Lymphoma (MCL)	2
1, 2	Completed	Treatment	Mantle Cell Lymphoma (MCL) / Non-Hodgkin's Lymphoma (NHL)	1
1, 2	Completed	Treatment	Multiple Myeloma (MM)	11
1, 2	Completed	Treatment	Multiple Myeloma (MM) / Multiple Myeloma in Relapse	1
1, 2	Completed	Treatment	Multiple Myeloma (MM) / Refractory / Relapses	1
1, 2	Completed	Treatment	Multiple Myeloma and Plasma Cell Neoplasm	2
1, 2	Completed	Treatment	Multiple Myeloma in Relapse	1
1, 2	Completed	Treatment	Non-Hodgkin's Lymphoma (NHL)	2
1, 2	Completed	Treatment	Non-Hodgkin's Lymphoma (NHL) / Peripheral T-Cell Lymphoma (PTCL)	1
1, 2	Completed	Treatment	Non-Small Cell Lung Cancer Recurrent / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIb Non-small Cell Lung Cancer	1
1, 2	Completed	Treatment	Plasma Cell Myeloma	2
1, 2	Completed	Treatment	Prostatic Neoplasms	1
1, 2	Completed	Treatment	Acute, relapsed Leukemia / Refractory Acute Leukemia	1
1, 2	Completed	Treatment	Refractory Multiple Myeloma	2
1, 2	Completed	Treatment	Relapsed Or Refractory Multiple Myeloma	1
1, 2	Not Yet Recruiting	Treatment	Cancer of Colon / Cancer of Liver / Cancer of Pancreas / Cancer of Rectum / Cancer of the Gallbladder / Glioblastoma Multiforme (GBM) / Multiple Myeloma (MM)	1
1, 2	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL)	1
1, 2	Recruiting	Treatment	Diffuse Large B-Cell Lymphoma (DLBCL)	1
1, 2	Recruiting	Treatment	Glioblastomas	1
1, 2	Recruiting	Treatment	Multiple Myeloma (MM)	4
1, 2	Recruiting	Treatment	Transplants and Implants	1
1, 2	Recruiting	Treatment	Treatments	1
1, 2	Terminated	Treatment	Advanced Malignancies / Metastatic Cancers / Tumors, Solid	1
1, 2	Terminated	Treatment	Brain and Central Nervous System Tumors / Melanoma / Tumors, Solid	1
1, 2	Terminated	Treatment	Colorectal Cancers	1
1, 2	Terminated	Treatment	Follicular Lymphoma (FL) / Mantle Cell Lymphoma (MCL) / Marginal Zone Lymphoma (MZL)	1
1, 2	Terminated	Treatment	Malignancies / Multiple Myeloma (MM)	1
1, 2	Terminated	Treatment	Malignant Lymphomas	2
1, 2	Terminated	Treatment	Medullary Thyroid Cancer (MTC)	1
1, 2	Terminated	Treatment	Multiple Myeloma (MM)	5
1, 2	Terminated	Treatment	Multiple Myeloma (MM) / Patient Participation	1
1, 2	Terminated	Treatment	Plasma Cell Myeloma / Plasmacytosis / Recurrent Plasma Cell Myeloma / Smoldering Plasma Cell Myeloma	1
1, 2	Terminated	Treatment	Refractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	2
1, 2	Terminated	Treatment	Refractory Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	1
1, 2	Unknown Status	Treatment	Multiple Myeloma (MM)	2
1, 2	Unknown Status	Treatment	Multiple Myeloma Patients Who Candidate for Autologous Peripheral Blood Stem Cell Transplantation	1
1, 2	Unknown Status	Treatment	Multiple Myeloma and Plasma Cell Neoplasm	1
1, 2	Unknown Status	Treatment	Myelodysplastic Syndromes (MDS)	1
1, 2	Unknown Status	Treatment	Non-Small Cell Lung Carcinoma (NSCLC)	1
1, 2	Unknown Status	Treatment	Recurrent Mantle Cell Lymphoma	1
1, 2	Unknown Status	Treatment	Transplantation, Renal / Uremia	1
1, 2	Withdrawn	Treatment	Lung Cancers	2
1, 2	Withdrawn	Treatment	Multiple Myeloma (MM)	2
1, 2	Withdrawn	Treatment	Multiple Myeloma (MM) / Refractory Multiple Myeloma	1
1, 2	Withdrawn	Treatment	Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma	1
2	Active Not Recruiting	Supportive Care	Multiple Myeloma (MM)	1
2	Active Not Recruiting	Treatment	Acute Myeloid Leukemia (AML)	1
2	Active Not Recruiting	Treatment	Acute Myeloid Leukemia (AML) / Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Therapy-Related Acute Myeloid Leukemia	1
2	Active Not Recruiting	Treatment	Amyloidosis	1
2	Active Not Recruiting	Treatment	Ann Arbor Stage III Grade 1 Follicular Lymphoma / Ann Arbor Stage III Grade 2 Follicular Lymphoma / Ann Arbor Stage III Grade 3 Follicular Lymphoma / Ann Arbor Stage IV Grade 1 Follicular Lymphoma / Ann Arbor Stage IV Grade 2 Follicular Lymphoma / Ann Arbor Stage IV Grade 3 Follicular Lymphoma / Grade 3a Follicular Lymphoma	1
2	Active Not Recruiting	Treatment	Chronic Antibody-mediated Transplant Rejection	1
2	Active Not Recruiting	Treatment	Chronic Graft Versus Host Disease	1
2	Active Not Recruiting	Treatment	Chronic Kidney Disease (CKD) / Multiple Myeloma (MM)	1
2	Active Not Recruiting	Treatment	Contiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Recurrent Mantle Cell Lymphoma / Stage I Mantle Cell Lymphoma / Stage III Mantle Cell Lymphoma / Stage IV Mantle Cell Lymphoma	1
2	Active Not Recruiting	Treatment	DS Stage I Plasma Cell Myeloma / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma	1
2	Active Not Recruiting	Treatment	DS Stage I Plasma Cell Myeloma / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma / Refractory Plasma Cell Myeloma	1
2	Active Not Recruiting	Treatment	Estrogen Receptor Positive / Recurrent Breast Carcinoma / Stage III Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer / Stage IV Breast Cancer	1
2	Active Not Recruiting	Treatment	Extramedullary Plasmacytoma / Isolated Plasmacytoma of Bone / Light Chain Deposition Disease / Primary Systemic Amyloidosis / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	1
2	Active Not Recruiting	Treatment	Graft Versus Host Disease (GVHD)	1
2	Active Not Recruiting	Treatment	High-Risk Cancer / Multiple Myeloma (MM)	1
2	Active Not Recruiting	Treatment	Light Chain Deposition Disease / Primary Systemic Amyloidosis	1
2	Active Not Recruiting	Treatment	Malignant Lymphomas	1
2	Active Not Recruiting	Treatment	Malignant Lymphomas / Neurologic toxicity / Therapy-Related Toxicity	1
2	Active Not Recruiting	Treatment	Mantle Cell Lymphoma (MCL)	2
2	Active Not Recruiting	Treatment	Multiple Myeloma (MM)	19
2	Active Not Recruiting	Treatment	Plasma Cell Myeloma	1
2	Active Not Recruiting	Treatment	Waldenström's Macroglobulinemia (WM)	3
2	Completed	Prevention	Chronic Chronic myelogenous leukemia / Chronic Lymphocytic Leukaemia (CLL) / Diffuse Large B-Cell Lymphoma (DLBCL) / Follicular Lymphoma (FL) / Leukemia, Acute / Lymphoma, B-Cell / Lymphoma, Hodgkins / Myelodysplasia / Small Lymphocytic Lymphoma	1
2	Completed	Prevention	Multiple Myeloma (MM)	1
2	Completed	Treatment	Adenocarcinoma of the Extrahepatic Bile Duct / Adenocarcinoma of the Gallbladder / Advanced Adult Primary Liver Cancer / Gastrointestinal Cancers / Localized Unresectable Adult Primary Liver Cancer / Recurrent Adult Primary Liver Cancer / Recurrent Extrahepatic Bile Duct Cancer / Recurrent Gallbladder Cancer / Unresectable Extrahepatic Bile Duct Cancer / Unresectable Gallbladder Cancer	1
2	Completed	Treatment	Adenocarcinoma of the Lung / Adenosquamous Cell Lung Cancer / Large Cell Lung Cancer / Malignant Pleural Effusions / Non-Small Cell Lung Cancer Recurrent / Squamous Cell Carcinoma of Lung / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer	1
2	Completed	Treatment	Adenocarcinoma of the Lung / Bronchoalveolar Cell Lung Cancer / Non-Small Cell Lung Cancer Recurrent / Non-Small Cell Lung Carcinoma (NSCLC) / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer	1
2	Completed	Treatment	Adenocarcinomas of the Gastroesophageal Junction / Advanced Gastric Cancer / Diffuse Adenocarcinoma of the Stomach / Intestinal Adenocarcinoma of the Stomach / Mixed Adenocarcinoma of the Stomach / Recurrent Gastric Cancer / Stage IIIB Gastric Cancer / Stage IIIC Gastric Cancer	1
2	Completed	Treatment	Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myelomonocytic Leukemia (M4) / Childhood Acute Basophilic Leukemia / Childhood Acute Eosinophilic Leukemia / Childhood Acute Erythroleukemia (M6) / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Minimally Differentiated Myeloid Leukemia (M0) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloblastic Leukemia With Maturation (M2) / Childhood Acute Myeloblastic Leukemia Without Maturation (M1) / Childhood Acute Myelomonocytic Leukemia (M4) / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML)	1
2	Completed	Treatment	Adult Diffuse Large B-Cell Lymphoma / B-Cell Non-Hodgkin Lymphomas(NHL) / Follicular Lymphoma (FL) / Mantle Cell Lymphoma (MCL) / Non-Hodgkin's Lymphoma (NHL) / T-Cell Non-Hodgkin Lymphoma	1
2	Completed	Treatment	Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Recurrent Adult Brain Tumor	1
2	Completed	Treatment	Adult Lymphocyte Depletion Hodgkin Lymphoma / Adult Lymphocyte Predominant Hodgkin Lymphoma / Adult Mixed Cellularity Hodgkin Lymphoma / Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma / Adult Nodular Sclerosis Hodgkin Lymphoma / Childhood Lymphocyte Depletion Hodgkin Lymphoma / Childhood Lymphocyte Predominant Hodgkin Lymphoma / Childhood Mixed Cellularity Hodgkin Lymphoma / Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma / Childhood Nodular Sclerosis Hodgkin Lymphoma / Recurrent Adult Hodgkin's Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Stage I Adult Hodgkin Lymphoma / Stage I Childhood Hodgkin Lymphoma / Stage II Adult Hodgkin Lymphoma / Stage II Childhood Hodgkin Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Childhood Hodgkin Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Childhood Hodgkin Lymphoma	1
2	Completed	Treatment	Adult Lymphocyte Depletion Hodgkin Lymphoma / Adult Mixed Cellularity Hodgkin Lymphoma / Adult Nodular Sclerosis Hodgkin Lymphoma / Recurrent Adult Hodgkin's Lymphoma	1
2	Completed	Treatment	Adult Primary Hepatocellular Carcinoma / Advanced Adult Primary Liver Cancer / Localized Unresectable Adult Primary Liver Cancer / Recurrent Adult Primary Liver Cancer	2
2	Completed	Treatment	Advanced Solid Tumors	1
2	Completed	Treatment	Allogeneic Stem Cell Transplantation / Refractory Autoimmune Cytopenia(s)	1
2	Completed	Treatment	Anaplastic Large Cell Lymphoma (ALCL) (ALK-1 Negative) / Angioimmunoblastic T-Cell Lymphoma / Enteropathy- Type T-cell Lymphoma / Extranodal NK/T-cell Lymphoma Nasal Type / Extranodal NK/T-cell Lymphoma, Nasal Type / Hepatosplenic T-Cell Lymphoma / Peripheral T-cell Lymphoma (Not Otherwise Specified) / Relapsed ALCL (ALK-1 Positive) Post Autologous Transplant	1
2	Completed	Treatment	Antibody-mediated Rejection / Late Rejection of Renal Transplant	1
2	Completed	Treatment	B-cell Adult Acute Lymphoblastic Leukemia / B-cell Adult Acute Lymphoblastic Leukemia (ALL) / Ph Positive Adult Acute Lymphoblastic Leukemia / Ph-positive Adult Acute Lymphoblastic Leukemia (ALL) / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia (ALL) / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Adult Acute Lymphoblastic Leukemia (ALL)	1
2	Completed	Treatment	B-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Lymphoblastic Lymphoma / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia	1
2	Completed	Treatment	Brain and Central Nervous System Tumors	2
2	Completed	Treatment	Breast Cancer	1
2	Completed	Treatment	CD20 Positive / Hematopoietic and Lymphoid Cell Neoplasm / Lymphocytic Neoplasm / Malignant Lymphomas	1
2	Completed	Treatment	Cancer, Bladder / Transitional Cell Cancer of the Renal Pelvis and Ureter	1
2	Completed	Treatment	Carcinoid tumour of the gastrointestinal tract / Islet Cell Tumor	1
2	Completed	Treatment	Carcinoma, Adenoid Cystic	1
2	Completed	Treatment	Carcinoma, Colorectal	1
2	Completed	Treatment	Chronic Graft Versus Host Disease	1
2	Completed	Treatment	Chronic Lymphocytic Leukemia (CLL) - Refractory / Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue / Nodal Marginal Zone Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Small Lymphocytic Lymphoma / Splenic Marginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)	1
2	Completed	Treatment	Ciliary Body and Choroid Melanoma, Medium/Large Size / Extraocular Extension Melanoma / Iris Melanoma / Recurrent Intraocular Melanoma / Recurrent Melanoma / Stage IV Melanoma	1
2	Completed	Treatment	Colorectal Cancers	1
2	Completed	Treatment	Contiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Stage I Mantle Cell Lymphoma / Stage III Mantle Cell Lymphoma / Stage IV Mantle Cell Lymphoma	1
2	Completed	Treatment	DS Stage I Plasma Cell Myeloma / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma	1
2	Completed	Treatment	Diffuse Large B-Cell Lymphoma (DLBCL)	2
2	Completed	Treatment	Duct Cell Adenocarcinoma of the Pancreas / Stage IV Pancreatic Cancer	1
2	Completed	Treatment	Epstein Barr Virus Infections / Epstein-Barr Virus Infections / Post-transplant Lymphoproliferative Disease (PTLD) / Solid Organ Transplant / Stem Cell Transplant (Bone Marrow Transplant)	1
2	Completed	Treatment	Esophageal Cancers	1
2	Completed	Treatment	Follicular Lymphoma (FL)	2
2	Completed	Treatment	Follicular Lymphoma (FL) / Lymphoma, B-Cell / Marginal Lymphoma	1
2	Completed	Treatment	Glioblastomas / Gliosarcoma	1
2	Completed	Treatment	Gliomas	1
2	Completed	Treatment	Graft Versus Host Disease (GVHD)	1
2	Completed	Treatment	Head and Neck Carcinoma	1
2	Completed	Treatment	Hodgkins Disease (HD)	1
2	Completed	Treatment	Indolent Lymphoma / Malignant Lymphomas / Mantle Cell Lymphoma (MCL) / Small Lymphocytic Lymphoma	1
2	Completed	Treatment	Insular Thyroid Cancer / Recurrent Thyroid Cancer / Stage II Follicular Thyroid Cancer / Stage II Papillary Thyroid Cancer / Stage IV Follicular Thyroid Cancer / Stage IV Papillary Thyroid Cancer	1
2	Completed	Treatment	Leukemia, Plasma Cell / Multiple Myeloma (MM)	1
2	Completed	Treatment	Leukemias	2
2	Completed	Treatment	Leukemias / Malignant Lymphomas / Myelodysplastic Syndrome	1
2	Completed	Treatment	Lung Cancers	2
2	Completed	Treatment	Lymphoma, B Cell / Lymphoma, B-Cell	1
2	Completed	Treatment	Lymphoma, B-Cell	2
2	Completed	Treatment	Lymphoma, Mucosa-Associated Lymphoid Tissue	1
2	Completed	Treatment	Lymphoplasmacytic Lymphoma / Waldenström's Macroglobulinemia (WM)	1
2	Completed	Treatment	MALT Lymphoma	1
2	Completed	Treatment	Malignant Lymphomas	13
2	Completed	Treatment	Malignant Lymphomas / Mantle Cell Lymphoma (MCL)	1
2	Completed	Treatment	Malignant Lymphomas / Non-Hodgkin's Lymphoma (NHL)	1
2	Completed	Treatment	Malignant Neoplasm of Stomach	1
2	Completed	Treatment	Mantle Cell Lymphoma (MCL)	2
2	Completed	Treatment	Mantle Cell Lymphoma (MCL) / Non-Hodgkin's Lymphoma (NHL)	1
2	Completed	Treatment	Mesothelioma, Malignant	2
2	Completed	Treatment	Metastatic Bladder Cancer / Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter / Recurrent Bladder Cancer / Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter / Recurrent Urethral Cancer / Stage III Bladder Cancer / Stage III Urethral Cancer / Stage IV Urethral Cancer / Transitional Cell Carcinoma of the Bladder / Ureteral Cancer	1
2	Completed	Treatment	Metastatic / Non-Small Cell Lung Carcinoma (NSCLC)	1
2	Completed	Treatment	Multiple Myeloma (MM)	55
2	Completed	Treatment	Multiple Myeloma (MM) / Renal Insuficiency	1
2	Completed	Treatment	Multiple Myeloma and Plasma Cell Neoplasm	6
2	Completed	Treatment	Multiple Myeloma and Plasma Cell Neoplasm / Neurologic toxicity	1
2	Completed	Treatment	Multiple Myeloma in Relapse / Refractory Multiple Myeloma / Relapsed and Bortezomib Refractory Multiple Myeloma	1
2	Completed	Treatment	Myelodysplastic Syndromes (MDS)	1
2	Completed	Treatment	Neuromyelitis Optica Spectrum Disorder	1
2	Completed	Treatment	Non Hodgkin's Follicular Lymphoma	1
2	Completed	Treatment	Non Small Cell Lung Carcinoma (NSCLC) / Non-Small Cell Lung Carcinoma (NSCLC)	1
2	Completed	Treatment	Non-Germinal B-Cell-like (GCB) Diffuse Large B-cell Lymphoma (DLBCL)	1
2	Completed	Treatment	Non-Hodgkin's Lymphoma (NHL)	4
2	Completed	Treatment	Non-Small Cell Lung Cancer Recurrent / Non-Small Cell Lung Carcinoma (NSCLC) / Stage IV Non-Small Cell Lung Cancer	1
2	Completed	Treatment	Non-Small Cell Lung Cancer Recurrent / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer	1
2	Completed	Treatment	Non-Small Cell Lung Carcinoma (NSCLC)	3
2	Completed	Treatment	Peripheral T-Cell Lymphoma (PTCL)	1
2	Completed	Treatment	Plasma Cell Myeloma	1
2	Completed	Treatment	Primary Peritoneal Cavity Cancer / Recurrent Ovarian Epithelial Cancer	1
2	Completed	Treatment	Primary Systemic Amyloidosis	1
2	Completed	Treatment	Prostate Cancer	3
2	Completed	Treatment	Prostate Neoplasms	1
2	Completed	Treatment	Recurrent Adenoid Cystic Carcinoma of the Oral Cavity / Recurrent Salivary Gland Cancer / Salivary Gland Adenoid Cystic Carcinoma / Stage III Adenoid Cystic Carcinoma of the Oral Cavity / Stage III Salivary Gland Cancer / Stage IV Adenoid Cystic Carcinoma of the Oral Cavity / Stage IV Salivary Gland Cancer	1
2	Completed	Treatment	Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Non-Hodgkin Lymphoma	1
2	Completed	Treatment	Recurrent Adult Soft Tissue Sarcoma / Stage III Adult Soft Tissue Sarcoma / Stage IV Adult Soft Tissue Sarcoma	1
2	Completed	Treatment	Recurrent Breast Cancer / Stage IV Breast Cancer	1
2	Completed	Treatment	Recurrent Classic Hodgkin Lymphoma / Refractory Classic Hodgkin Lymphoma	1
2	Completed	Treatment	Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma	1
2	Completed	Treatment	Recurrent Mantle Cell Lymphoma	1
2	Completed	Treatment	Recurrent Melanoma / Stage IV Melanoma	1
2	Completed	Treatment	Recurrent Nasopharyngeal Cancer / Stage IV Nasopharyngeal Cancer	1
2	Completed	Treatment	Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Recurrent Verrucous Carcinoma of the Larynx / Recurrent Verrucous Carcinoma of the Oral Cavity / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IV Verrucous Carcinoma of the Larynx / Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVA Squamous Cell Carcinoma of the Oropharynx / Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IVA Verrucous Carcinoma of the Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Oropharynx / Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IVB Verrucous Carcinoma of the Oral Cavity / Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVC Squamous Cell Carcinoma of the Oropharynx / Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IVC Verrucous Carcinoma of the Oral Cavity / Tongue Cancer	1
2	Completed	Treatment	Refractory Cold Agglutinin Disease	1
2	Completed	Treatment	Refractory Plasma Cell Myeloma	1
2	Completed	Treatment	Rejection, Transplant	1
2	Completed	Treatment	Relapse/Refractory Multiple Myeloma	1
2	Completed	Treatment	Relapsed Follicular Lymphoma	1
2	Completed	Treatment	Relapsed Or Refractory Multiple Myeloma	1
2	Completed	Treatment	Renal Cancers	3
2	Completed	Treatment	Sarcomas	1
2	Completed	Treatment	Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	3
2	Completed	Treatment	Transplant, Kidney / Transplantation, Kidney	1
2	Completed	Treatment	Waldenström's Macroglobulinemia (WM)	4
2	No Longer Available	Not Available	Multiple Myeloma (MM)	1
2	Not Yet Recruiting	Treatment	Acquired Pure Red Cell Aplasia	1
2	Not Yet Recruiting	Treatment	High Risk / Newly Diagnosed / Plasma Cell Myeloma	1
2	Not Yet Recruiting	Treatment	Immune Thrombocytopenia	1
2	Not Yet Recruiting	Treatment	Mantle Cell Lymphoma (MCL)	1
2	Not Yet Recruiting	Treatment	Multiple Myeloma (MM)	3
2	Not Yet Recruiting	Treatment	Refractory Multiple Myeloma	1
2	Recruiting	Basic Science	Diffuse Large B-Cell Lymphoma (DLBCL)	1
2	Recruiting	Supportive Care	Multiple Myeloma (MM)	1
2	Recruiting	Treatment	Acquired Hemophilia A	1
2	Recruiting	Treatment	Acute Lymphoblastic Leukaemia Recurrent / Burkitt's Lymphoma / High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements / Lymphoblastic lymphoma (Precursor T-lymphoblastic lymphoma/leukemia) refractory / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Burkitt Leukemia / Recurrent Burkitt Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements / Refractory Acute Lymphoblastic Leukemia / Refractory Burkitt Leukemia / Refractory Burkitt Lymphoma / Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements	1
2	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL)	1
2	Recruiting	Treatment	Acute Lymphoblastic Leukemia, in Relapse	1
2	Recruiting	Treatment	Acute Myeloid Leukemia (AML)	1
2	Recruiting	Treatment	Adult-onset Immunodeficiency	1
2	Recruiting	Treatment	Autoimmune Encephalitis	1
2	Recruiting	Treatment	Autoimmune Hemolytic Anemia / Autoimmune Hemolytic Anemia and Autoimmune Thrombocytopenia	1
2	Recruiting	Treatment	Diffuse Large B-Cell Lymphoma (DLBCL)	1
2	Recruiting	Treatment	Disorders, Lymphoproliferative / HHV-8 / Human Immunodeficiency Virus (HIV) Infections / Malignancies	1
2	Recruiting	Treatment	Extramedullary Plasmacytoma / Multiple Myeloma (MM)	1
2	Recruiting	Treatment	Graft Versus Host Disease (GVHD)	1
2	Recruiting	Treatment	Haematological Malignancies	1
2	Recruiting	Treatment	High Grade Serous Carcinoma / Ovarian Neoplasm Epithelial	1
2	Recruiting	Treatment	Idiopathic Multicentric Castleman's Disease	1
2	Recruiting	Treatment	Interstitial Lung Diseases (ILD) / Scleroderma / Sclerosis, Progressive Systemic	1
2	Recruiting	Treatment	Light Chain (AL) Amyloidosis, Stage 3B	1
2	Recruiting	Treatment	Lymphoplasmacytic Lymphoma / Waldenström's Macroglobulinemia (WM)	1
2	Recruiting	Treatment	Mantle Cell Lymphoma (MCL)	1
2	Recruiting	Treatment	Marginal Zone Lymphoma (MZL)	1
2	Recruiting	Treatment	Multiple Myeloma (MM)	10
2	Recruiting	Treatment	Multiple Myeloma (MM) / Plasma Cell Myeloma	2
2	Recruiting	Treatment	Newly Diagnosed Multiple Myeloma	1
2	Recruiting	Treatment	Peripheral T Cell Lymphoma (PTCL) / Peripheral T-Cell Lymphoma (PTCL)	1
2	Recruiting	Treatment	Plasma Cell Myeloma	1
2	Recruiting	Treatment	Plasma Cell Myeloma / Renal Failure	1
2	Recruiting	Treatment	Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma	1
2	Recruiting	Treatment	Refractory Multiple Myeloma	1
2	Recruiting	Treatment	Relapsed Acute Promyelocytic Leukemia	1
2	Recruiting	Treatment	Relapsed and/or Refractory Cutaneous T-cell Lymphoma	1
2	Recruiting	Treatment	Waldenström's Macroglobulinemia (WM)	2
2	Terminated	Prevention	Agnogenic Myeloid Metaplasia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Diffuse Large B-Cell Lymphoma (DLBCL) / Follicular Lymphoma (FL) / Graft Versus Host Disease (GVHD) / Leukemia, Acute / Mantle Cell Lymphoma (MCL) / Marginal Zone Lymphoma (MZL) / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Small Lymphocytic Lymphoma	1
2	Terminated	Prevention	Disorder of Transplanted Kidney	1
2	Terminated	Prevention	Graft Versus Host Disease (GVHD)	1
2	Terminated	Prevention	Malignancies / Multiple Myeloma (MM) / Plasma Cell Myeloma	1
2	Terminated	Prevention	Multiple Myeloma (MM)	1
2	Terminated	Treatment	Acinar Cell Adenocarcinoma of the Pancreas / Duct Cell Adenocarcinoma of the Pancreas / Stage IV Pancreatic Cancer	1
2	Terminated	Treatment	Acute Lymphoblastic Leukaemias (ALL)	1
2	Terminated	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Leukemia, B-Cell / Leukemia, T-Cell / Non-Hodgkin's Lymphoma (NHL)	1
2	Terminated	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Lymphoma, Lymphoblastic	1
2	Terminated	Treatment	Acute Lymphocytic Leukemia (ALL) / Acute Myeloid Leukemia (AML) / Mixed Lineage Acute Leukemia	1
2	Terminated	Treatment	Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Promyelocytic Leukemia (M3) / Adult Erythroleukemia (M6a) / Adult Pure Erythroid Leukemia (M6b) / Secondary Acute Myeloid Leukemia (Secondary AML, sAML)	1
2	Terminated	Treatment	Adenocarcinoma, Bronchiolo-Alveolar / Non-Small Cell Lung Carcinoma (NSCLC)	1
2	Terminated	Treatment	Bronchiolitis Obliterans (BO)	1
2	Terminated	Treatment	Cardiac Transplant / Heart Transplantation / Primary Heart Transplant	1
2	Terminated	Treatment	Cervical Cancers	1
2	Terminated	Treatment	Disorders, Lymphoproliferative	1
2	Terminated	Treatment	Extranodal NK-T-CELL LYMPHOMA	1
2	Terminated	Treatment	Follicular Lymphoma (FL)	4
2	Terminated	Treatment	Heart Transplantation	1
2	Terminated	Treatment	Hodgkins Disease (HD)	1
2	Terminated	Treatment	Leukemia, Lymphocytic, Chronic, B-Cell / Mantle Cell Lymphoma (MCL)	1
2	Terminated	Treatment	Leukemias	1
2	Terminated	Treatment	Leukemias / Myelodysplastic Syndrome	1
2	Terminated	Treatment	Lymphoma, B-Cell / Non-Hodgkin's Lymphoma (NHL)	1
2	Terminated	Treatment	Lymphoma, Mucosa-Associated Lymphoid Tissue	1
2	Terminated	Treatment	MDS	1
2	Terminated	Treatment	Malignant Lymphomas	3
2	Terminated	Treatment	Malignant Neoplasm of Pancreas	1
2	Terminated	Treatment	Malignant Neoplasm of Stomach	1
2	Terminated	Treatment	Mantle Cell Lymphoma (MCL)	1
2	Terminated	Treatment	Metastatic Breast Cancer	1
2	Terminated	Treatment	Metastatic Renal Cell Carcinoma	1
2	Terminated	Treatment	Multiple Myeloma (MM)	17
2	Terminated	Treatment	Myasthenia Gravis / Rheumatoid Arthritis / Systemic Lupus Erythematosus (SLE)	1
2	Terminated	Treatment	Non-Hodgkin's Lymphoma (NHL)	3
2	Terminated	Treatment	Non-Small Cell Lung Cancer Recurrent / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer	1
2	Terminated	Treatment	Non-Small Cell Lung Carcinoma (NSCLC)	2
2	Terminated	Treatment	Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma	1
2	Terminated	Treatment	Refractory Multiple Myeloma	1
2	Terminated	Treatment	Refractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	1
2	Terminated	Treatment	Refractory Plasma Cell Myeloma	1
2	Terminated	Treatment	Stage IIIB or IV Non-Small Cell Lung Cancer	1
2	Terminated	Treatment	Waldenström's Macroglobulinemia (WM)	1
2	Unknown Status	Treatment	Acute Myeloid Leukemia (AML)	1
2	Unknown Status	Treatment	Bortezomib / Cyclophosphamide / Dexamethasone / Granulocyte Colony-Stimulating Factor / Plasma Cell Myeloma	1
2	Unknown Status	Treatment	End Stage Renal Disease (ESRD)	1
2	Unknown Status	Treatment	Leukemia, Plasma Cell / Multiple Myeloma (MM)	1
2	Unknown Status	Treatment	Mantle Cell Lymphoma (MCL)	1
2	Unknown Status	Treatment	Mesothelioma	1
2	Unknown Status	Treatment	Multiple Myeloma (MM)	6
2	Unknown Status	Treatment	Multiple Myeloma and Plasma Cell Neoplasm	3
2	Unknown Status	Treatment	Waldenström's Macroglobulinemia (WM)	1
2	Withdrawn	Prevention	Multiple Myeloma (MM)	1
2	Withdrawn	Treatment	Acute Lymphocytic Leukemia (ALL) / Leukemias	1
2	Withdrawn	Treatment	Amyloidosis / Immunoglobulin Light Chain Deposition	1
2	Withdrawn	Treatment	High Grade B-Cell Lymphoma, Not Otherwise Specified / Recurrent Burkitt Lymphoma / Recurrent Diffuse Large B-Cell Lymphoma / Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements / Refractory Burkitt Lymphoma / Refractory Diffuse Large B Cell Lymphoma / Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements	1
2	Withdrawn	Treatment	Malignancies	1
2	Withdrawn	Treatment	Malignant Lymphomas	1
2	Withdrawn	Treatment	Mantle Cell Lymphoma (MCL)	1
2	Withdrawn	Treatment	Multiple Myeloma (MM)	5
2	Withdrawn	Treatment	Multiple Myeloma (MM) / Multiple Myeloma in Relapse	1
2	Withdrawn	Treatment	Multiple Myeloma (MM) / Plasma Cell Myeloma	1
2	Withdrawn	Treatment	Nasopharyngeal Carcinoma	1
2	Withdrawn	Treatment	Non-Hodgkin's Lymphoma (NHL)	1
2	Withdrawn	Treatment	Ovarian Cancer	1
2	Withdrawn	Treatment	Plasma Cell Myeloma	1
2	Withdrawn	Treatment	Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	1
2, 3	Completed	Treatment	Multiple Myeloma (MM)	2
2, 3	Not Yet Recruiting	Treatment	Multiple Myeloma (MM)	1
2, 3	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Acute Lymphoblastic Lymphoma	1
2, 3	Terminated	Treatment	Multiple Myeloma (MM)	1
3	Active Not Recruiting	Treatment	Acute Myeloid Leukemia (AML) / Granulocytic Sarcoma / Leukaemia cutis / Myeloid Neoplasm	1
3	Active Not Recruiting	Treatment	Adult T Acute Lymphoblastic Leukemia / Ann Arbor Stage II Adult Lymphoblastic Lymphoma / Ann Arbor Stage II Childhood Lymphoblastic Lymphoma / Ann Arbor Stage III Adult Lymphoblastic Lymphoma / Ann Arbor Stage III Childhood Lymphoblastic Lymphoma / Ann Arbor Stage IV Adult Lymphoblastic Lymphoma / Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma / Childhood T Acute Lymphoblastic Leukemia	1
3	Active Not Recruiting	Treatment	Amyloidosis	1
3	Active Not Recruiting	Treatment	DS Stage I Plasma Cell Myeloma / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma	1
3	Active Not Recruiting	Treatment	Mantle Cell Lymphoma (MCL)	2
3	Active Not Recruiting	Treatment	Multiple Myeloma (MM)	15
3	Active Not Recruiting	Treatment	Plasma Cell Myeloma	1
3	Active Not Recruiting	Treatment	Previously Untreated Symptomatic Multiple Myeloma	1
3	Active Not Recruiting	Treatment	Waldenström's Macroglobulinemia (WM)	1
3	Completed	Not Available	Multiple Myeloma (MM)	1
3	Completed	Diagnostic	Multiple Myeloma (MM)	1
3	Completed	Treatment	Amyloidosis	1
3	Completed	Treatment	Chronic Renal Failure With Uremic Nephropathy	1
3	Completed	Treatment	Diffuse Large B-Cell Lymphoma (DLBCL)	1
3	Completed	Treatment	Effects of Chemotherapy / Multiple Myeloma (MM)	1
3	Completed	Treatment	Light Chain Deposition Disease / Primary Systemic Amyloidosis	1
3	Completed	Treatment	Multiple Myeloma (MM)	29
3	Completed	Treatment	Non-Hodgkin's Lymphoma (NHL)	1
3	Completed	Treatment	Plasma Cell Myeloma	1
3	No Longer Available	Not Available	Multiple Myeloma (MM)	1
3	Not Yet Recruiting	Treatment	Idiopathic Thrombocytopenic Purpura / Immune Thrombocytopenia	1
3	Recruiting	Treatment	Acute Lymphoblastic Leukemia, Pediatric	1
3	Recruiting	Treatment	Auto Stem Cell Transplant / Multiple Myeloma (MM)	1
3	Recruiting	Treatment	Intrahepatic Cholangiocarcinoma	1
3	Recruiting	Treatment	Multiple Myeloma (MM)	8
3	Recruiting	Treatment	Newly Diagnosed Multiple Myeloma	1
3	Recruiting	Treatment	Plasma Cell Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	1
3	Suspended	Treatment	Relapsed/Refractory Multiple Myeloma	1
3	Terminated	Treatment	AL Amyloidosis	1
3	Terminated	Treatment	Multiple Myeloma (MM)	5
3	Terminated	Treatment	Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	1
3	Unknown Status	Treatment	Extramedullary Plasmacytoma	1
3	Unknown Status	Treatment	Multiple Myeloma (MM)	3
3	Unknown Status	Treatment	Transplantation, Kidney	1
3	Withdrawn	Treatment	Malignant Lymphomas	1
3	Withdrawn	Treatment	Multiple Myeloma (MM)	1
4	Active Not Recruiting	Treatment	Multiple Myeloma (MM)	1
4	Active Not Recruiting	Treatment	Relapsed and/or Refractory Multiple Myeloma	1
4	Completed	Not Available	Hematological Neoplasms / Multiple Myeloma (MM)	2
4	Completed	Not Available	Multiple Myeloma (MM)	7
4	Completed	Prevention	Transplantation, Kidney	1
4	Completed	Treatment	Chronic Kidney Disease (CKD) / IgA Nephropathy	1
4	Completed	Treatment	HLA Sensitization	1
4	Completed	Treatment	Multiple Myeloma (MM)	3
4	Recruiting	Treatment	Hematological Neoplasms	1
4	Recruiting	Treatment	Multiple Myeloma (MM)	1
4	Recruiting	Treatment	Newly Diagnosed Multiple Myeloma	1
4	Recruiting	Treatment	Patients Awaiting a Living Kidney Donation	1
4	Recruiting	Treatment	Pompe's Disease	1
4	Recruiting	Treatment	Waldenström's Macroglobulinemia (WM)	1
4	Terminated	Treatment	Multiple Myeloma (MM)	1
4	Unknown Status	Treatment	Multiple Myeloma (MM)	1
4	Withdrawn	Treatment	Hematuria / Nephritis, Lupus / Proteinuria	1
Not Available	Active Not Recruiting	Not Available	Multiple Myeloma (MM)	1
Not Available	Active Not Recruiting	Treatment	Adult Grade III Lymphomatoid Granulomatosis / B-Cell Chronic Lymphocytic Leukemia / Contiguous Stage II Adult Burkitt Lymphoma / Contiguous Stage II Adult Diffuse Large Cell Lymphoma / Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Contiguous Stage II Adult Lymphoblastic Lymphoma / Contiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Grade 3 Follicular Lymphoma / Contiguous Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Burkitt Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Progressive Hairy Cell Leukemia, Initial Treatment / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Diffuse Small Cleaved Cell Lymphoma / Stage I Adult Immunoblastic Large Cell Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Multiple Myeloma / Stage I Small Lymphocytic Lymphoma / Stage II Multiple Myeloma / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Multiple Myeloma / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Small Lymphocytic Lymphoma / Untreated Hairy Cell Leukemia / Waldenström's Macroglobulinemia (WM)	1
Not Available	Active Not Recruiting	Treatment	Amyloidosis; Systemic	1
Not Available	Available	Not Available	Multiple Myeloma (MM)	1
Not Available	Available	Not Available	Multiple Myeloma (MM) / Multiple Myeloma in Relapse / Refractory Multiple Myeloma / Relapsed Multiple Myeloma	1
Not Available	Completed	Not Available	Amyloidosis	1
Not Available	Completed	Not Available	Cardiotoxins / Heart Failure, Systolic / Multiple Myeloma (MM)	1
Not Available	Completed	Not Available	Multiple Myeloma (MM)	2
Not Available	Completed	Treatment	Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes (MDS)	1
Not Available	Completed	Treatment	Amyloidosis	1
Not Available	Completed	Treatment	Amyloidosis / Light Chain and Heavy Chain Deposition Disease (LHCDD or MIDD) / Light Chain Deposition Disease (LCDD or MIDD) / Monoclonal Immunoglobulin Deposition Disease (MIDD)	1
Not Available	Completed	Treatment	Multiple Myeloma (MM)	1
Not Available	Recruiting	Not Available	Chemotherapy Induced Peripheral Neuropathy (CIPN) / Multiple Myeloma (MM)	1
Not Available	Recruiting	Treatment	Antibody-mediated Rejection	1
Not Available	Recruiting	Treatment	Childhood Acute Lymphoblastic Leukemia	1
Not Available	Terminated	Treatment	Follicular Lymphoma (FL) / Malignant Lymphomas / Marginal Zone Lymphoma (MZL)	1
Not Available	Terminated	Treatment	Sickle Cell Anemia / Sickle Cell-hemoglobin C Disease / Sickle Cell-β0-thalassemia	1

Pharmacoeconomics

Manufacturers

• Millennium pharmaceuticals inc

Packagers

• Ben Venue Laboratories Inc.
• Janssen-Ortho Inc.
• Millennium Pharmaceuticals

Dosage forms

Form	Route	Strength
Injection, powder, lyophilized, for solution	Intravenous	1 mg/1mL
Injection, powder, lyophilized, for solution	Intravenous	3.5 mg/1
Injection, powder, for solution	Intravenous; Subcutaneous	3.5 mg
Powder, for solution	Intravenous
Powder, for solution	Intravenous; Subcutaneous
Injection, powder, for solution	Intravenous	1.0 mg
Injection, powder, lyophilized, for solution	Intravenous; Subcutaneous	3.5 mg/1
Powder, for solution	Intravenous; Subcutaneous	3.5 mg

Prices

Unit description	Cost	Unit
Velcade 3.5 mg vial	1590.0USD	vial

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
Unlock Additional Data
US6083903	No	2000-07-04	2014-10-28
CA2203936	No	2005-04-12	2015-10-27
US5780454	Yes	1998-07-14	2017-11-03
US6958319	Yes	2005-10-25	2022-07-25
US6713446	Yes	2004-03-30	2022-07-25
US8962572	No	2015-02-24	2032-11-03

Additional Data Available

Filed On
Filed On
The date on which a patent was filed with the relevant government.
Learn more

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	139-143	Thermo Fisher Scientific Bortezomib Safety Data Sheet
water solubility	The solubility of bortezomib, as the monomeric boronic acid, is 3.3 to 3.8 mg/mL in a pH range of 2 to 6.5.	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.0532 mg/mL	ALOGPS
logP	0.89	ALOGPS
logP	1.53	ChemAxon
logS	-3.9	ALOGPS
pKa (Strongest Acidic)	13.04	ChemAxon
pKa (Strongest Basic)	-0.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	124.44 Å2	ChemAxon
Rotatable Bond Count	9	ChemAxon
Refractivity	99.37 m3·mol-1	ChemAxon
Polarizability	40.48 Å3	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	-	0.6935
Blood Brain Barrier	-	0.6533
Caco-2 permeable	-	0.6576
P-glycoprotein substrate	Substrate	0.5909
P-glycoprotein inhibitor I	Non-inhibitor	0.785
P-glycoprotein inhibitor II	Non-inhibitor	1.0
Renal organic cation transporter	Non-inhibitor	0.9445
CYP450 2C9 substrate	Non-substrate	0.7145
CYP450 2D6 substrate	Substrate	0.8918
CYP450 3A4 substrate	Non-substrate	0.5209
CYP450 1A2 substrate	Non-inhibitor	0.855
CYP450 2C9 inhibitor	Non-inhibitor	0.8267
CYP450 2D6 inhibitor	Non-inhibitor	0.9304
CYP450 2C19 inhibitor	Non-inhibitor	0.8108
CYP450 3A4 inhibitor	Non-inhibitor	0.7308
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9604
Ames test	Non AMES toxic	0.7439
Carcinogenicity	Non-carcinogens	0.8064
Biodegradation	Not ready biodegradable	0.9943
Rat acute toxicity	2.4537 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9936
hERG inhibition (predictor II)	Non-inhibitor	0.8593

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted GC-MS Spectrum - GC-MS	Predicted GC-MS	Not Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
LC-MS/MS Spectrum - LC-ESI-qTof , Positive	LC-MS/MS	Not Available
LC-MS/MS Spectrum - LC-ESI-qTof , Positive	LC-MS/MS	Not Available
MS/MS Spectrum - , positive	LC-MS/MS	splash10-0a4i-0035900000-122163b342b985220f63
MS/MS Spectrum - , positive	LC-MS/MS	splash10-016r-1397000000-e168634cfe7e1453d742

Taxonomy

Description

This compound belongs to the class of organic compounds known as phenylalanine and derivatives. These are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Phenylalanine and derivatives

Alternative Parents

N-acyl-alpha amino acids and derivatives / Alpha amino acid amides / Amphetamines and derivatives / Pyrazinecarboxamides / 2-heteroaryl carboxamides / Fatty amides / Heteroaromatic compounds / Secondary carboxylic acid amides / Boronic acids / Organic metalloid saltsAzacyclic compounds / Carbonyl compounds / Hydrocarbon derivatives / Monoalkylboranes / Organic oxides / Organonitrogen compounds / Organopnictogen compounds

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Substituents

Phenylalanine or derivatives / N-acyl-alpha amino acid or derivatives / Alpha-amino acid amide / Amphetamine or derivatives / Pyrazine carboxylic acid or derivatives / Pyrazinecarboxamide / 2-heteroaryl carboxamide / Monocyclic benzene moiety / Fatty amide / PyrazineBenzenoid / Fatty acyl / Heteroaromatic compound / Boronic acid derivative / Boronic acid / Carboxamide group / Secondary carboxylic acid amide / Azacycle / Organic metalloid salt / Organoheterocyclic compound / Hydrocarbon derivative / Organic oxide / Organooxygen compound / Organonitrogen compound / Organoboron compound / Organopnictogen compound / Alkylborane / Carbonyl group / Organic oxygen compound / Organic nitrogen compound / Monoalkylborane / Organic salt / Aromatic heteromonocyclic compound

show 23 more

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

pyrazines, amino acid amide, L-phenylalanine derivative (CHEBI:52717)