Atherosclerosis

Also known as: Atheromatosis / Atherosclerotic cardiovascular disease / Arteriosclerosis

DrugDrug NameDrug Description
DB01432CholestyramineCholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
DB01095FluvastatinFluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It is also the first entirely synthetic HMG-CoA reductase inhibitor and is structurally distinct from the fungal derivatives of this therapeutic class. Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin.
DB00627NiacinA water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has pellagra-curative, vasodilating, and antilipemic properties.
DB01098RosuvastatinRosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
DrugDrug NameTargetType
DB01432CholestyramineBile acidstarget
DB01095Fluvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01095FluvastatinCytochrome P450 2C9enzyme
DB01095FluvastatinCytochrome P450 3A4enzyme
DB01095FluvastatinCytochrome P450 2C8enzyme
DB01095FluvastatinCytochrome P450 2D6enzyme
DB01095FluvastatinCytochrome P450 2C19enzyme
DB01095FluvastatinCytochrome P450 1A1enzyme
DB01095FluvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01095FluvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01095FluvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01095FluvastatinSolute carrier family 15 member 1transporter
DB01095FluvastatinCytochrome P450 3A5enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 2B7enzyme
DB01095FluvastatinCanalicular multispecific organic anion transporter 1transporter
DB01095FluvastatinCytochrome P450 2B6enzyme
DB00627NiacinHydroxycarboxylic acid receptor 2target
DB00627NiacinNicotinamide N-methyltransferasetarget
DB00627NiacinNicotinate-nucleotide pyrophosphorylase [carboxylating]target
DB00627NiacinHydroxycarboxylic acid receptor 3target
DB00627NiacinSolute carrier family 22 member 5transporter
DB00627NiacinSolute carrier organic anion transporter family member 2B1transporter
DB00627NiacinMonocarboxylate transporter 1transporter
DB00627NiacinCytochrome P450 2D6enzyme
DB00627NiacinSodium-coupled monocarboxylate transporter 1transporter
DB00627NiacinMonocarboxylate transporter 4transporter
DB01098Rosuvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01098RosuvastatinCytochrome P450 2C9enzyme
DB01098RosuvastatinMultidrug resistance-associated protein 4transporter
DB01098RosuvastatinMultidrug resistance-associated protein 1transporter
DB01098RosuvastatinCytochrome P450 2C19enzyme
DB01098RosuvastatinCytochrome P450 3A4enzyme
DB01098RosuvastatinCytochrome P450 3A5enzyme
DB01098RosuvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01098RosuvastatinCystine/glutamate transportertransporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01098RosuvastatinBile salt export pumptransporter
DB01098RosuvastatinATP-binding cassette sub-family G member 2transporter
DB01098RosuvastatinSerum albumincarrier
DB01098RosuvastatinCanalicular multispecific organic anion transporter 1transporter
DB01098RosuvastatinSolute carrier family 22 member 8transporter
DrugDrug NamePhaseStatusCount
DB00973Ezetimibe0Enrolling by Invitation1
DB00635Prednisone0Not Yet Recruiting1
DB01098Rosuvastatin0Completed2
DB00641Simvastatin0Enrolling by Invitation1
DB00945Acetylsalicylic acid1Completed1
DB09302Alirocumab1Active Not Recruiting1
DB00758Clopidogrel1Completed1
DB06311Darapladib1Completed12
DB00343Diltiazem1Completed1
DB00973Ezetimibe1Completed1
DB06705Gadofosveset trisodium1Completed1
DB09374Indocyanine green acid form1Completed1
DB12270Losmapimod1Completed2
DB00683Midazolam1Completed1
DB05119Rilapladib1Completed3
DB01098Rosuvastatin1Completed2
DB09153Sodium Chloride1Terminated1
DB12000Apabetalone1 / 2Completed1
DB01164Calcium Chloride1 / 2Recruiting1
DB04398Lactic Acid1 / 2Recruiting1
DB00959Methylprednisolone1 / 2Unknown Status1
DB00761Potassium chloride1 / 2Recruiting1
DB09153Sodium Chloride1 / 2Recruiting1
DB09153Sodium Chloride1 / 2Unknown Status1
DB00945Acetylsalicylic acid2Completed1
DB12000Apabetalone2Completed1
DB00126Ascorbic acid2Terminated1
DB12758Atreleuton2Completed1
DB06168Canakinumab2Completed1
DB00608Chloroquine2Recruiting1
DB00169Cholecalciferol2Completed1
DB00758Clopidogrel2Completed2
DB06311Darapladib2Completed4
DB12362Diaminopropanol tetraacetic acid2Not Yet Recruiting1
DB00783Estradiol2Completed2
DB12469Fasudil2Completed1
DB01611Hydroxychloroquine2Recruiting1
DB12270Losmapimod2Completed1
DB00227Lovastatin2Completed1
DB02701Nicotinamide2Recruiting1
DB12971Pactimibe2Completed1
DB00806Pentoxifylline2Completed2
DB12520Plozalizumab2Completed1
DB00396Progesterone2Completed1
DB00178Ramipril2Completed1
DB05119Rilapladib2Completed1
DB06372Rilonacept2Completed1
DB01098Rosuvastatin2Completed1
DB00203Sildenafil2Recruiting1
DB01261Sitagliptin2Recruiting1
DB00177Valsartan2Completed1
DB00163Vitamin E2Terminated1
DB09030Vorapaxar2Completed1
DB00945Acetylsalicylic acid2 / 3Unknown Status1
DB09026Aliskiren2 / 3Terminated1
DB00115Cyanocobalamin2 / 3Completed1
DB14476DL-alpha-Tocopherol2 / 3Completed1
DB00783Estradiol2 / 3Completed1
DB00158Folic Acid2 / 3Completed1
DB00227Lovastatin2 / 3Completed1
DB00635Prednisone2 / 3Completed1
DB00165Pyridoxine2 / 3Completed1
DB01399Salsalate2 / 3Completed2
DB00197Troglitazone2 / 3Completed1
DB00284Acarbose3Completed1
DB00945Acetylsalicylic acid3Terminated1
DB00945Acetylsalicylic acid3Unknown Status1
DB00381Amlodipine3Completed1
DB01076Atorvastatin3Completed6
DB01076Atorvastatin3Recruiting1
DB11936Bempedoic acid3Completed1
DB00542Benazepril3Completed1
DB06168Canakinumab3Active Not Recruiting1
DB00796Candesartan cilexetil3Completed1
DB06441Cangrelor3Terminated1
DB01136Carvedilol3Completed1
DB00310Chlorthalidone3Completed1
DB01166Cilostazol3Unknown Status1
DB00758Clopidogrel3Terminated1
DB00758Clopidogrel3Unknown Status1
DB00375Colestipol3Completed1
DB06311Darapladib3Completed1
DB00343Diltiazem3Completed1
DB00973Ezetimibe3Completed7
DB00973Ezetimibe3Terminated1
DB01023Felodipine3Completed1
DB01039Fenofibrate3Completed1
DB01095Fluvastatin3Completed1
DB00695Furosemide3Completed1
DB00222Glimepiride3Completed1
DB01067Glipizide3Completed1
DB01275Hydralazine3Completed1
DB00999Hydrochlorothiazide3Completed1
DB01306Insulin Aspart3Completed1
DB01307Insulin Detemir3Completed1
DB00030Insulin Human3Completed1
DB00047Insulin glargine3Completed1
DB01249Iodixanol3Completed1
DB00722Lisinopril3Completed1
DB00331Metformin3Completed1
DB00264Metoprolol3Completed1
DB05528Mipomersen3Completed1
DB00688Mycophenolate mofetil3Terminated1
DB00627Niacin3Completed2
DB00627Niacin3Terminated1
DB00275Olmesartan3Completed1
DB01229Paclitaxel3Active Not Recruiting1
DB01132Pioglitazone3Completed1
DB00175Pravastatin3Completed1
DB00635Prednisone3Terminated1
DB00178Ramipril3Completed2
DB00912Repaglinide3Completed1
DB00206Reserpine3Completed1
DB00412Rosiglitazone3Completed3
DB01098Rosuvastatin3Active Not Recruiting1
DB01098Rosuvastatin3Completed5
DB00641Simvastatin3Completed4
DB00641Simvastatin3Terminated2
DB00877Sirolimus3Terminated1
DB05399Succinobucol3Unknown Status1
DB11104Sulfur hexafluoride3Completed1
DB00864Tacrolimus3Terminated1
DB01162Terazosin3Completed1
DB00384Triamterene3Completed1
DB00177Valsartan3Completed1
DB09030Vorapaxar3Completed2
DB05692Vorapaxar3Terminated1
DB09030Vorapaxar3Terminated1
DB00682Warfarin3Terminated1
DB06151Acetylcysteine4Unknown Status1
DB00945Acetylsalicylic acid4Completed6
DB00945Acetylsalicylic acid4Recruiting1
DB00945Acetylsalicylic acid4Terminated1
DB09302Alirocumab4Recruiting1
DB00594Amiloride4Terminated1
DB00381Amlodipine4Terminated1
DB00335Atenolol4Completed1
DB01076Atorvastatin4Active Not Recruiting1
DB01076Atorvastatin4Completed5
DB01076Atorvastatin4Terminated2
DB01076Atorvastatin4Unknown Status2
DB01076Atorvastatin4Withdrawn1
DB13100Biguanide4Recruiting1
DB00201Caffeine4Completed1
DB01166Cilostazol4Completed1
DB00758Clopidogrel4Completed3
DB00758Clopidogrel4Recruiting2
DB00930Colesevelam4Active Not Recruiting1
DB06695Dabigatran etexilate4Terminated1
DB00514Dextromethorphan4Completed1
DB00975Dipyridamole4Completed2
DB00584Enalapril4Unknown Status1
DB00016Erythropoietin4Recruiting1
DB01276Exenatide4Recruiting1
DB00973Ezetimibe4Completed7
DB00973Ezetimibe4Terminated3
DB01095Fluvastatin4Unknown Status1
DB01241Gemfibrozil4Withdrawn1
DB00999Hydrochlorothiazide4Terminated1
DB01306Insulin Aspart4Completed1
DB01306Insulin Aspart4Recruiting1
DB01307Insulin Detemir4Completed1
DB11629Laropiprant4Terminated1
DB00451Levothyroxine4Completed2
DB00678Losartan4Terminated1
DB04835Maraviroc4Completed1
DB00331Metformin4Completed1
DB00331Metformin4Not Yet Recruiting1
DB00331Metformin4Recruiting2
DB09282Molsidomine4Completed1
DB00688Mycophenolate mofetil4Completed1
DB04861Nebivolol4Completed1
DB00627Niacin4Active Not Recruiting1
DB00627Niacin4Completed1
DB00627Niacin4Terminated2
DB00627Niacin4Unknown Status1
DB09539Omega-3-acid ethyl esters4Completed1
DB00946Phenprocoumon4Terminated1
DB08860Pitavastatin4Active Not Recruiting1
DB00178Ramipril4Completed1
DB06155Rimonabant4Unknown Status1
DB06228Rivaroxaban4Completed1
DB01098Rosuvastatin4Completed5
DB01098Rosuvastatin4Not Yet Recruiting1
DB01098Rosuvastatin4Recruiting1
DB01098Rosuvastatin4Terminated3
DB01098Rosuvastatin4Unknown Status1
DB00641Simvastatin4Completed5
DB00641Simvastatin4Unknown Status1
DB01261Sitagliptin4Completed2
DB00421Spironolactone4Recruiting1
DB00624Testosterone4Unknown Status1
DB08816Ticagrelor4Completed1
DB08816Ticagrelor4Recruiting2
DB00162Vitamin A4Unknown Status2
DB00682Warfarin4Completed1
DB00054AbciximabNot AvailableCompleted1
DB03128AcetylcholineNot AvailableUnknown Status1
DB00945Acetylsalicylic acidNot AvailableCompleted3
DB00945Acetylsalicylic acidNot AvailableRecruiting1
DB00051AdalimumabNot AvailableCompleted1
DB00640AdenosineNot AvailableUnknown Status1
DB09302AlirocumabNot AvailableRecruiting1
DB09026AliskirenNot AvailableUnknown Status1
DB00335AtenololNot AvailableCompleted1
DB01076AtorvastatinNot AvailableCompleted3
DB01076AtorvastatinNot AvailableRecruiting1
DB01076AtorvastatinNot AvailableUnknown Status1
DB01076AtorvastatinNot AvailableWithdrawn1
DB11121ChloroxylenolNot AvailableCompleted1
DB00169CholecalciferolNot AvailableCompleted1
DB00758ClopidogrelNot AvailableCompleted1
DB00975DipyridamoleNot AvailableCompleted1
DB00584EnalaprilNot AvailableRecruiting1
DB00005EtanerceptNot AvailableCompleted1
DB00973EzetimibeNot AvailableRecruiting1
DB00973EzetimibeNot AvailableWithdrawn1
DB01039FenofibrateNot AvailableCompleted1
DB00813FentanylNot AvailableNot Yet Recruiting1
DB13961Fish oilNot AvailableEnrolling by Invitation1
DB01095FluvastatinNot AvailableCompleted1
DB00158Folic AcidNot AvailableActive Not Recruiting1
DB00222GlimepirideNot AvailableCompleted1
DB00065InfliximabNot AvailableCompleted1
DB00161L-ValineNot AvailableCompleted1
DB00722LisinoprilNot AvailableCompleted1
DB00678LosartanNot AvailableRecruiting1
DB00678LosartanNot AvailableUnknown Status1
DB00563MethotrexateNot AvailableActive Not Recruiting1
DB00264MetoprololNot AvailableCompleted1
DB00683MidazolamNot AvailableNot Yet Recruiting1
DB00627NiacinNot AvailableCompleted3
DB00627NiacinNot AvailableTerminated1
DB00627NiacinNot AvailableUnknown Status1
DB01229PaclitaxelNot AvailableCompleted1
DB01132PioglitazoneNot AvailableCompleted2
DB00571PropranololNot AvailableCompleted1
DB06228RivaroxabanNot AvailableRecruiting1
DB00412RosiglitazoneNot AvailableCompleted1
DB01098RosuvastatinNot AvailableRecruiting1
DB12163SarpogrelateNot AvailableUnknown Status1
DB00658SevelamerNot AvailableRecruiting1
DB00641SimvastatinNot AvailableCompleted3
DB00641SimvastatinNot AvailableRecruiting2
DB00641SimvastatinNot AvailableWithdrawn1
DB05679UstekinumabNot AvailableCompleted1
DB00177ValsartanNot AvailableCompleted1