Titanium dioxide


Titanium dioxide
Accession Number
Small Molecule

Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium, chemical formula TiO2. When used as a pigment, it is called titanium white, Pigment White 6 (PW6), or CI 77891. Generally it is sourced from ilmenite, rutile and anatase.

  • dióxido de titanio
  • óxido de titanio(4)
External IDs
C.I. 77891 / CI 77891 / CI-77891 / E 171 / E-171 / INS NO.171 / INS-171 / NSC-15204 / NSC-200C
Active Moieties
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sunblock Lotion SPF 15Lotion5.6 %TopicalNorwood Packaging Ltd.Not applicableNot applicableCanada
Sunblock Lotion SPF 30Lotion10.4 %TopicalNorwood Packaging Ltd.Not applicableNot applicableCanada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
3 Concept Eyes Glossing Waterful Foundation Milk IvoryCream1.44 g/40gTopicalNanda Co., Ltd.2013-08-01Not applicableUs
3 Concept Eyes Glossing Waterful Foundation Natural IvoryCream1.44 g/40gTopicalNanda Co., Ltd.2013-08-01Not applicableUs
3 Concept Eyes Glossing Waterful Foundation Nude BeigeCream1.44 g/40gTopicalNanda Co., Ltd.2013-08-01Not applicableUs
3 Concept Eyes Glossing Waterful Foundation Soft BeigeCream1.44 g/40gTopicalNanda Co., Ltd.2013-08-01Not applicableUs
3 Concept Eyes Honey Face Chiffon Fluid 001Cream3.71 mg/40mLTopicalNanda Co., Ltd.2013-08-01Not applicableUs
3 Concept Eyes Honey Face Chiffon Fluid 002Cream3.71 mg/40mLTopicalNanda Co., Ltd.2013-08-01Not applicableUs
3 Concept Eyes Liquid Foundation Ivory BeigeCream2.78 mg/30mLTopicalNanda Co., Ltd.2013-08-01Not applicableUs
3 Concept Eyes Liquid Foundation Lace BeigeCream2.78 mg/30mLTopicalNanda Co., Ltd.2013-08-01Not applicableUs
3 Concept Eyes Slim Fit Pact Natural IvoryPowder0.57 g/8gTopicalNanda Co., Ltd.2013-08-01Not applicableUs
3 Concept Eyes Slim Fit Pact Soft BeigePowder0.57 g/8gTopicalNanda Co., Ltd.2013-08-01Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
01 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
02 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
03 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
04 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
05 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
06 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
07 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
08 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
09 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
10 Armani Prima Control Glow Moisturizer SBS SPF 35Titanium dioxide (19 mg/1mL) + Octinoxate (50 mg/1mL)CreamTopicalLaboratoires Biocosm Sarl2018-01-01Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Merle Norman Preventage Hand Treatment SPF 15Titanium dioxide (10.622 g/113g) + Octinoxate (2.147 g/113g)CreamTopicalMerle Norman Cosmetics2012-09-012013-05-06Us
Sodium Sulfacetamide SulfurTitanium dioxide (50 mg/1g) + Meradimate (50 mg/1g) + Octasulfur (40 mg/1mL) + Sulfacetamide sodium (100 mg/1mL)KitTopicalRiver's Edge Pharmaceuticals, LLC2008-06-012011-08-31Us
Zo Medical Zo Multi-therapy Hydroquinone SystemTitanium dioxide (0.08 g/1g) + Hydroquinone (0.04 g/1g) + Hydroquinone (0.04 g/1g)KitZo Skin Health Inc2014-03-01Not applicableUs
CAS number
Average: 79.865
Monoisotopic: 79.937771
Chemical Formula
InChI Key



In the pharmaceutical industry, titanium dioxide is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups.

Associated Conditions

As Sunscreen agent : protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation. Biocompatible Materials : Synthetic or natural materials, other than drugs, that are used to replace or repair any body tissues or bodily function.

Mechanism of action

Diminish the penetration of ultraviolet (UV) light through the epidermis by absorbing UV radiation within a specific wavelength range. The amount and wavelength of UV radiation absorbed are affected by the molecular structure of the sunscreen agent.

UMacrophage receptor MARCONot AvailableHumans

When male and female rats were fed a diet containing titanium dioxide (100 g/kg) for a period of about 32 days, a significant retention of titanium of 0.06 and 0.11 mg/kg wet weight was found only in the muscles; no retention was observed in the liver, spleen, kidney, bone, plasma, or erythrocytes

Volume of distribution

Six hours after titanium dioxide was administered to rats through IV injection at 250 mg/kg body weight, the highest concentration appeared in the liver; after 24 hours, the highest concentration was detected in the celiac lymph nodes, which filter the lymph from the liver.

Protein binding

The researchers/ determined blood levels of titanium dioxide (anatase) following oral ingestion of titanium-dioxide capsules and/or powder in six adult men (24-66 years of age). Titanium dioxide was absorbed by the gastrointestinal tract in a size dependent manner: smaller particles (0.16 um) were more readily absorbed than larger ones (0.38 um). Before the experiment, the background blood levels of titanium dioxide in these men ranged from approximately 6 to 18 ug/L. Blood levels reached up to approximately 50 ug/L or 100 ug/L between 4 and 12 hours after intake of 23 mg or 46 mg titanium dioxide, respectively


Rats were intraperitoneal injected with 1.60 g/100 g body wt of TiO(2) in saline solution. Organs (liver, spleen, lung) were processed for histological evaluation. Reactive oxygen species (ROS) in alveolar macrophages obtained by bronchoalveolar lavage (BAL) were evaluated using the nitroblue tetrazolium test and quantitative evaluation by digital image analysis. The histological analysis of organs revealed the presence of titanium in the parenchyma of these organs with no associated tissue damage. Although in lung alveolar macrophages TiO(2) induced a significant rise in ROS generation, it failed to cause tissue alteration. This finding may be attributed to an adaptive response.

Route of elimination

The kinetics of TiO2 elimination in the rat lung following its deposition after 7 hr exposure at 10 and 50 mg/cu m were determined for periods up to 140 days.The retention half-time was 14 days for the first clearance phase and 88 days thereafter.

Half life

The kinetics of TiO2 elimination in the rat lung following its deposition after 7 hr exposure at 10 and 50 mg/cu m were determined for periods up to 140 days...The retention half-time was 14 days for the first clearance phase and 88 days thereafter.


The clearance of titanium dioxide from the lungs was studied in rats after inhalation of 15 or 100 mg/cu m. The average median aerodynamic diameter of the titanium dioxide particles was 1.48 um. After a single exposure, about 40-45% of the deposited particles were cleared from the lung in 25 days. At 15 mg/cu m, 0.7% was found in the hilar lymph nodes indicating penetration of titanium dioxide particles from alveoli into the lymphatic system and partial clearance by the lymphatic route. The clearance rate was similar after intra-tracheal administration of titanium dioxide. At an exposure of 100 mg/cu m, the clearance rate decreased drastically. /Other researchers/ demonstrated the presence of titanium dioxide in the lymphatic systems of 3 workers employed in processing titanium dioxide pigments.


Rat - LD50 Intratracheal (>100ug/kg ) Effects: Structural or functional changes in bronchi and trachea. There is inadequate evidence in humans for the carcinogenicity of titanium dioxide. Cancer in experimental animals: There is sufficient evidence in experimental animals for the carcinogenicity of titanium dioxide. Overall evaluation: Titanium dioxide is possibly carcinogenic to humans (Group 2B).

Affected organisms
Not Available
Not Available
Pharmacogenomic Effects/ADRs
Not Available


Drug Interactions
Not Available
Food Interactions
Not Available


General References
  1. Olmedo DG, Tasat DR, Guglielmotti MB, Cabrini RL: Effect of titanium dioxide on the oxidative metabolism of alveolar macrophages: an experimental study in rats. J Biomed Mater Res A. 2005 May 1;73(2):142-9. [PubMed:15742364]
  2. Wikipedia [Link]
  3. Drugs.com [Link]
  4. ChemIDplus [Link]
  5. Pubchem [Link]
External Links
KEGG Compound
PubChem Compound
PubChem Substance
AHFS Codes
  • 84:12.00 — Astringents and Deodorants
  • 84:80.00 — Sunscreen Agents

Clinical Trials

Clinical Trials
1CompletedNot AvailableHealthy Volunteers2
1CompletedOtherHealthy Participants1
1CompletedSupportive CareHealthy Volunteers1
1Not Yet RecruitingTreatmentBladder Small Cell Neuroendocrine Carcinoma / Castration-Resistant Prostate Carcinoma / Metastatic Bladder Urothelial Carcinoma / Metastatic Urethral Urothelial Carcinoma / Prostate Carcinoma Metastatic in the Bone / Prostate Neuroendocrine Neoplasm / Prostate Small Cell Carcinoma / Stage III Bladder Cancer AJCC v8 / Stage III Prostate Cancer AJCC v8 / Stage III Urethral Cancer AJCC v8 / Stage IV Bladder Cancer AJCC v8 / Stage IV Prostate Cancer AJCC v8 / Stage IV Urethral Cancer AJCC v8 / Stage IVA Bladder Cancer AJCC v8 / Stage IVB Bladder Cancer AJCC v8 / Transitional Cell Carcinoma / Ureter Small Cell Carcinoma1
1RecruitingTreatmentVisceral Leishmaniasis1
1, 2CompletedTreatmentObstructive Sleep Apnea (OSA)1
1, 2RecruitingTreatmentCancer of the Ovary1
2Active Not RecruitingTreatmentLung Cancers1
2CompletedSupportive CareAdvanced Malignant Neoplasm / Dermatologic Complication / Dermatologic Complications / Neoplasms, Malignant1
2Not Yet RecruitingTreatmentFunctional Popliteal Artery Entrapment Syndrome / Popliteal artery entrapment syndrome1
2RecruitingTreatmentAcute Gouty Arthritis1
2RecruitingTreatmentMalignant Neoplasm of Stomach1
2RecruitingTreatmentTriple-Negative Breast Cancer (TNBC)1
2TerminatedTreatmentMediastinal Neoplasms1
2, 3RecruitingTreatmentHeart Arrest1
3CompletedSupportive CareDermatologic Complications / Unspecified Adult Solid Tumor, Protocol Specific1
3CompletedTreatmentDiabetes Mellitus (DM)1
3Not Yet RecruitingTreatmentMajor Depressive Episode / Suicidal Thoughts1
3RecruitingTreatmentAcute Lymphoblastic Leukemia, Pediatric1
3RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cancer1
3RecruitingTreatmentCervical Cancers1
3RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
3TerminatedTreatmentHead and Neck Carcinoma / Lung Cancers / Metastatic Cancers1
4Active Not RecruitingTreatmentHealthy Volunteers1
4CompletedNot AvailableSunburn1
4CompletedTreatmentTrigger Finger Disorder1
4Enrolling by InvitationSupportive CareColectomy / Opioids Use / Postoperative pain / Surgery, Colorectal1
4Not Yet RecruitingTreatmentCaesarean Sections1
4Not Yet RecruitingTreatmentEmbryo Transfer1
4Not Yet RecruitingTreatmentHigh Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
4RecruitingDiagnosticCancer, Breast / Sentinel Lymph Node Biopsy1
4RecruitingTreatmentCardiothoracic Surgery1
4TerminatedTreatmentAnalgesia / Aspiration / Pain NOS / Tibial Fractures1
Not AvailableCompletedPreventionPigmentation From Visible Light1
Not AvailableNot Yet RecruitingNot AvailableHepatocellular,Carcinoma1


Not Available
Not Available
Dosage forms
CreamTopical1.44 g/40g
CreamTopical3.71 mg/40mL
CreamTopical2.78 mg/30mL
PowderTopical0.57 g/8g
LipstickTopical0.02 g/4.5g
LipstickTopical0.11 g/4.5g
LipstickTopical0.15 g/4.5g
LipstickTopical0.16 g/4.5g
LipstickTopical0.17 g/4.5g
LipstickTopical0.22 g/4.5g
LipstickTopical0.13 g/4.5g
LipstickTopical0.03 g/4.5g
LipstickTopical0.18 g/4.5g
LipstickTopical0.09 g/4.5g
LipstickTopical0.01 g/1.1g
LipstickTopical0.23 g/1.1g
LipstickTopical0.26 g/1.1g
LipstickTopical0.04 g/1.1g
LipstickTopical0.22 g/1.1g
LipstickTopical0.08 g/1.1g
PowderTopical0.07 g/5g
PowderTopical0.31 g/5g
PowderTopical0.37 g/5g
PowderTopical0.12 g/5g
PowderTopical0.67 g/8g
PowderTopical0.68 g/8g
PowderTopical0.47 g/8g
PowderTopical0.52 g/8g
LiquidTopical0.16 g/6g
LiquidTopical0.19 g/6g
LiquidTopical0.06 g/6g
LiquidTopical0.65 g/5mL
LipstickTopical0.02 g/3.5g
LipstickTopical0.12 g/3.5g
LipstickTopical0.05 g/3.5g
LipstickTopical0.17 g/3.5g
LipstickTopical0.04 g/3.5g
LipstickTopical0.07 g/3.5g
LipstickTopical0.10 g/3.5g
LipstickTopical0.20 g/3.5g
LipstickTopical0.15 g/3.5g
LipstickTopical0.29 g/3.5g
LipstickTopical0.14 g/3.5g
LipstickTopical0.13 g/3.5g
LipstickTopical0.014 g/3.5g
LipstickTopical0.010 g/3.5g
LipstickTopical0.01 g/3.5g
PowderTopical1.03 g/11g
PowderTopical1.63 g/11g
LipstickTopical0.129 g/1g
LipstickTopical0.03 g/1g
LipstickTopical0.097 g/1g
LipstickTopical0.107 g/1g
LipstickTopical0.005 g/1g
LipstickTopical0.11 g/1g
LipstickTopical0.081 g/1g
PowderTopical0.12 g/25g
StickTopical0.47 g/10g
StickTopical0.4 g/10g
StickTopical0.85 mg/0.085g
StickTopical0.015 g/0.085g
StickTopical0.017 g/0.085g
StickTopical0.005 g/0.085g
PowderTopical0.42 g/3.5g
PowderTopical0.30 g/3.5g
PowderTopical0.36 g/3.5g
PowderTopical0.23 g/3.5g
CreamTopical78.6 mg/1mL
CreamTopical121.6 mg/1mL
CreamTopical77.2 mg/1mL
PowderTopical0.387 g/4.3g
CreamTopical5 %
LotionTopical2.4 %
CreamTopical1.8 %
PowderTopical1.7 g/12g
CreamTopical2.46 g/30mL
StickTopical8.8 %
LiquidTopical8.9 %
PowderTopical9.8 g/100g
LiquidTopical45 mL/100mL
CreamTopical6.4 %
CreamTopical8 %
CreamTopical7.3 %
CreamTopical7.6 %
PowderTopical6.9 g/100g
CreamTopical1.72 g/50g
CreamTopical2.6 g/50g
CreamTopical115.2 mg/1mL
CreamTopical0.0934 g/1g
CreamCutaneous4.64 mL/50mL
CreamTopical40.25 mg/1mL
LiquidTopical7.5 %
CreamTopical7.0 g/100g
CreamTopical4.4 %
CreamTopical18.8 mg/1mL
CreamTopical4.8 %
CreamTopical2.5 %
StickTopical2.5 %
LotionTopical2.2 %
LotionTopical6.48 %
LotionTopical8.1 %
LotionTopical9.72 %
LotionTopical6 g/100mL
CreamTopical8.46 g/100g
CreamTopical170 mg/1mL
LotionTopical60 mg/1mL
LiquidTopical33.2 mg/1mL
LiquidTopical110 mg/1mL
LiquidTopical62 mg/1mL
PowderTopical25 g/100g
PowderTopical12 g/100g
CreamTopical0.3 g/2g
PowderTopical20 g/100g
CreamTopical3.42 g/30mL
CreamTopical47 mg/1mL
CreamTopical3.85 g/100mL
LiquidTopical0.038 mg
CreamTopical3.25 g/35mL
CreamTopical3.69 g/40g
PowderTopical24 g/100g
CreamTopical4.33 %
LotionTopical10.145 %
CreamTopical69 mg/1mL
CreamTopical6.45 g/100g
CreamTopical6.4 g/100g
CreamTopical12.1 mg/100mL
PowderTopical6 g/100g
PowderTopical8.4 g/100g
LotionTopical5 g/100mL
CreamTopical15.8 g
CreamTopical19.8 g
LiquidTopical6.2 g
LiquidTopical5.7 g
LiquidTopical7.7 g
LiquidTopical8.2 g
LiquidTopical8.4 g
LiquidTopical7.5 g
PowderTopical7.3 g
PowderTopical7 g
PowderTopical6.2 g
PowderTopical11.1 g
PowderTopical5.6 g
CreamTopical9.8525 g/100mL
PowderTopical0.89 g/5g
PowderTopical0.98 g/5g
PowderTopical0.55 g/5g
PowderTopical0.67 g/5g
PowderTopical0.28 g/5g
CreamTopical120 mg/1mL
CreamTopical8.5 g/100mL
CreamTopical36.5 mg/1mL
LotionTopical10.157 g/100g
CreamTopical5.8 %
PasteTopical5.8 g/100g
CreamTopical11.2 %
CreamTopical8.8 %
CreamTopical8.2 %
CreamTopical14.85 %
CreamTopical9.9 %
PowderTopical15 g/100g
StickTopical10.0 %
StickTopical4 %
StickTopical4.0 g/100g
StickTopical7.5 %
LiquidTopical28 mg/1mL
LiquidTopical47 mg/1mL
LiquidTopical20 mg/1mL
CreamTopical25 mg/1mL
LiquidTopical25 mg/1mL
CreamTopical70 mg/1mL
CreamTopical68 mg/1mL
CreamTopical63 mg/1mL
CreamTopical23 mg/1mL
EmulsionTopical62 mg/1mL
LiquidTopical19 mg/1mL
EmulsionTopical30 mg/1mL
SolutionTopical94.5 mg/1mL
CreamTopical84 mg/1mL
CreamTopical28 mg/1mL
SolutionTopical18.9 mg/1mL
LiquidTopical18.9 mg/1mL
CreamTopical81 mg/1mL
LiquidTopical81 mg/1mL
LiquidTopical70 mg/1mL
SolutionTopical70 mg/1mL
SolutionTopical81 mg/1mL
StickTopical80 mg/5g
PasteTopical684 mg/12g
PasteTopical1.896 g/12g
CreamTopical0.65625 g/31.25g
CreamTopical656 mg/31.25g
CreamTopical3960 mg/40g
StickTopical1.31 g/8g
PowderTopical12.1 %
CreamTopical24 %
CreamTopical13.8 %
PowderTopical4.2 %
CreamTopical75 mg/1mL
CreamTopical0.0273 g/1mL
CreamTopical2.0 mL/100mL
CreamTopical20 %
SuspensionTopical11.8 %
SuspensionTopical8.5 %
SuspensionTopical4.0 %
LiquidTopical1.80 g/15mL
CreamTopical1.00 g/4.2g
CreamTopical1.49 g/6.5g
CreamTopical1.52 g/6.5g
LipstickTopical1.8 g/100g
CreamTopical9 g/100g
CreamTopical4.9 mg/0.1g
CreamTopical49 mg/1g
GelTopical7.8 mL/100mL
CreamTopical3.225 %
LotionTopical2 %
CreamTopical50 mg/1mL
CreamTopical30 mg/1g
LotionTopical10 mg/1mL
LotionTopical104 mg/1mL
LotionTopical9.7 mg/1mL
LotionTopical68 mg/1mL
LotionTopical61 mg/1mL
PowderTopical3 %
CreamTopical71 uL/1mL
LotionTopical210 mg/2mL
PowderTopical5.53 g/100g
CreamTopical21.9 mg/1mL
CreamTopical1 mg/1mL
CreamTopical1.38 g/50mL
CreamTopical2.905 g/100mL
PowderTopical7 g/100g
PowderTopical5.8 %
PowderTopical0.494 g/13g
LiquidTopical5.0 mL/100mL
CreamTopical0.0171 g/1mL
PowderTopical2.2 g/100g
LiquidTopical4.2 mL/100mL
LiquidTopical1.0 mL/100mL
PowderTopical4.0 g/100g
CreamTopical10.08 g/100g
CreamCutaneous4.2 mg/100mg
CreamTopical4.05 g/50g
LotionTopical2.14 g/60mL
LotionTopical5 g/100g
PowderTopical1.80 g/15g
CreamTopical9 %
PowderTopical4 g/100g
CreamTopical80 mg/1g
LotionTopical2 mL/100mL
StickTopical0.04 g/1g
CreamCutaneous3.5 g/35g
PowderTopical3.7 %
LiquidTopical3.5 %
LotionTopical7.2 %
LotionTopical12 %
SuspensionTopical3 %
PowderTopical10 g/100g
StickTopical5 g
LotionTopical53.9 mg/1mL
LiquidTopical97 mg/1mL
LiquidTopical83 mg/1mL
LiquidTopical84 mg/1mL
LiquidTopical78 mg/1mL
LotionTopical4.03 g
CreamTopical5.6601 g/100mL
CreamTopical4.2 g/100mL
CreamTopical10 mL/100mL
OilTopical5 g/100mL
CreamTopical5 g/100mL
CreamTopical7.5 g/100mL
CreamTopical1.3500 g/45.0000g
CreamTopical3 g/100g
CreamTopical3.1500 g/45.0000g
CreamTopical7 g/100g
CreamTopical3.1680 g/45.0000g
CreamTopical6.8 %
CreamTopical3.4 %
PasteTopical4.2 g/100g
CreamCutaneous4.01 mL/35mL
CreamCutaneous2.35 g/10g
PowderCutaneous2.35 g/10g
StickTopical20 mg/1g
LiquidTopical4 %
StickTopical24.15 g/100g
StickTopical23 g/100g
EmulsionTopical10.4 %
EmulsionTopical5.68 %
EmulsionTopical6.37 %
PowderTopical1.96 g/100g
LotionTopical0.504 g/12g
CreamTopical20.78 %
CreamTopical31.6 mg/1mL
CreamTopical2.886 g/60g
CreamCutaneous1.77 mg/100mL
CreamTopical765 mg/9g
LotionTopical41.1 mg/1mL
CreamCutaneous4.48 g/45g
PowderTopical5 %
CreamTopical54 mg/1mL
LotionTopical25.8 mg/1mL
LotionTopical37.4 mg/1mL
CreamTopical74 mg/1mL
PowderTopical10.5 g/100g
CreamTopical0.38 mg/45mL
CreamTopical121.6 mg/1g
CreamTopical1.5 g/50g
Cream, augmentedTopical
LotionTopical78.5 mg/1mL
LotionTopical150 mg/1mL
Spray, suspensionTopical7.8 g/100mL
LiquidTopical5 %
PowderTopical1.179423 g/9g
PowderTopical0.895536 g/9g
PowderTopical0.9558 g/12g
PowderTopical13.1 g/100g
CreamTopical86.4 mg/1mL
LotionTopical6.5 g/100g
LotionTopical250 mg/1mL
CreamTopical106.6 mg/1mL
LotionTopical5.5 mL/50mL
CreamTopical155 mg/1mL
CreamTopical11 %
CreamTopical2.4 g/30g
PowderTopical0.05 g/1g
PowderTopical0.55 g/11g
Lotion / shampooTopical
LotionTopical8 %
EmulsionTopical70 mg/1mL
CreamTopical2.522 g/25mL
LiquidTopical2.31 g/20mL
LiquidTopical3.09 g/30mL
CreamTopical115.2 g/1mL
CreamTopical153.2 mg/1mL
CreamTopical154.3 mg/1mL
CreamTopical151.4 mg/1mL
CreamTopical5.35 g/100mL
PowderTopical3.0 %
PowderTopical100 mg/1g
LiquidTopical32.6 mg/1mL
CreamTopical61 mg/1g
CreamTopical12.1 g/100g
PowderCutaneous0.92 g/13g
CreamTopical11.8 g
CreamTopical5.269 g/100mL
LotionTopical33.9 mg/1mL
SprayTopical4.9 %
EmulsionTopical60 mg/1mL
LotionTopical2.7 %
CreamTopical19.90 mL/100mL
PowderTopical5.77 g/100g
CreamTopical11.5 mg/1mL
LotionTopical15.3 mg/1mL
CreamTopical80 mg/1mL
LotionTopical70 mg/1mL
CreamTopical2 %
LotionTopical4.2 g/100mL
LotionTopical0.04601 g/1mL
LotionTopical4.30 mL/100mL
CreamTopical3.8 g/100g
CreamTopical16 g/100g
PowderTopical7.0 g/100g
CreamCutaneous7.5 mg/1g
CreamCutaneous3.77 mL/50mL
CreamCutaneous9.3 mg/1g
PowderCutaneous0.98 g/11g
CreamCutaneous3.5 mL/50mL
CreamCutaneous3.57 mL/50mL
CreamTopical2.28 g/10g
CreamTopical4 %
LotionTopical5.4 mL/100mL
CreamCutaneous1.19 mL/35mL
CreamTopical12 %
CreamCutaneous1.36 mL/50mL
LiquidTopical1.98 g/17g
CreamTopical0.1175 1/50mL
CreamTopical5.85 g/50mL
CreamCutaneous1.45 mL/50mL
CreamTopical95 mg/1g
CreamTopical92 mg/1g
CreamTopical18.8 mg/1g
LiquidTopical24 mg/1mL
LiquidTopical66 mg/1mL
PowderTopical75 mg/1g
PowderTopical41.1 mg/1g
LotionTopical28 mg/1mL
LotionTopical29 mg/1mL
LiquidTopical32 mg/1mL
LotionTopical9.1 %
LotionTopical7.25 %
LotionTopical480 mg/1mL
CreamTopical77 mg/1mL
LotionTopical7.6 mL/100mL
PowderTopical2.1 g/100g
LiquidTopical2.4 mL/100mL
CreamCutaneous1.18 mL/60mL
CreamCutaneous2.10 mL/60mL
EmulsionTopical0.65 g/1g
EmulsionTopical0.66 g/1g
EmulsionTopical85 mg/1g
EmulsionTopical100.8 mg/1g
LotionTopical22 %
CreamTopical0.8 g/35mL
CreamTopical0.87 mL/35mL
CreamTopical3.95 g/100g
LotionTopical102 mg/1mL
LotionTopical76.5 mg/1mL
CreamTopical2.94 g/70mL
PowderTopical2.06 g/12g
CreamTopical39 mg/1mL
EmulsionTopical31 mg/1mL
LotionTopical0.2625 mg/2.5mL
CreamTopical7.2 g
CreamTopical1.52 g/7g
CreamCutaneous3.25 mL/35mL
CreamCutaneous1.68 g/12g
PowderCutaneous1.68 g/12g
CreamTopical3.26 g/35mL
LiquidTopical4.7 mL/100mL
PowderTopical8.0 %
CreamTopical16 %
CreamTopical0.02 g/20g
CreamTopical4 mg/100mL
LotionTopical4 mL/100mL
LotionTopical4.7 mL/100mL
PowderTopical0.24 g/10g
PowderTopical0.21 g/1g
PowderTopical0.07 g/1g
PowderTopical2.38 g/10g
PowderTopical1.43 g/6g
PowderTopical0.358 g/8.33g
PowderTopical0.72 g/8g
PowderTopical0.38 g/4.25g
CreamTopical6 mg/100mL
CreamTopical2.6 mg/100mL
CreamTopical2.96 mg/100mL
CreamCutaneous2.59 g/50g
PowderTopical0.84 g/12g
CreamTopical1.4 mL/100mL
CreamTopical956.25 mg/4.25g
LotionTopical4 g/100g
CreamCutaneous2.32 g/25g
CreamTopical12.5 %
PowderTopical2 %
CreamTopical11.5 %
LiquidTopical7.4 %
LiquidTopical5.2 %
StickTopical4.8 %
LiquidTopical6 %
LiquidTopical8.60 %
PowderTopical11.00 %
PowderTopical14.3 %
PowderTopical3.5 %
PasteTopical4 mg/1mL
CreamTopical52.8 mg/1mL
CreamTopical61.6 mg/1mL
CreamTopical9.1 %
LotionTopical5.6 g/100mL
LiquidTopical5.6 g/100mL
CreamTopical0.5 g/100g
CreamTopical100 mg/1mL
LotionTopical40 uL/1mL
CreamTopical6.96 %
LotionTopical2.866 g/44.4mL
PowderTopical12.9 g/100g
CreamTopical4 g/100mL
LiquidTopical13 g/100mL
CreamTopical2.25 g/13g
LiquidTopical5 g/100mL
PowderTopical540 mg/12g
PowderTopical864 mg/12g
PowderTopical0.54 g/12g
PowderTopical22.7 %
PowderTopical24.6 %
CreamTopical10.7 %
EmulsionTopical12.7 %
EmulsionTopical11.45 %
EmulsionTopical11.1 %
CreamTopical1488 mg/36.3g
LiquidTopical13.9 %
StickTopical250 mg/10g
StickTopical410 mg/10g
Aerosol, foamTopical
StickTopical0.60 g/9g
StickTopical0.55 g/9g
CreamTopical0.04 g/5.5g
CreamTopical13 g/13g
LotionTopical6.7 g/100g
LotionTopical54.9 mg/1mL
LotionTopical6.90 g/100mL
PowderTopical3 g/100g
CreamTopical9.7 %
CreamTopical8.86 %
CreamTopical3.1 g
PowderTopical0.7 g/10g
Lotion / shampooTopical80 mg/1mL
LiquidTopical2.9445 g/44.4mL
LotionTopical8.46 %
Spray, suspensionTopical
StickTopical170 mg/1g
Lotion / shampooTopical120 mg/1g
Aerosol, sprayTopical
PowderTopical4.5 %
LotionTopical1 g/66mL
LotionTopical1 g/88mL
CreamTopical12 mg/1mL
CreamTopical8.1 %
CreamTopical9.72 %
LotionTopical10 %
LotionTopical5.67 %
CreamTopical6.1 %
CreamTopical3.9 %
CreamTopical8.9 %
CreamTopical6.5 %
LotionTopical5.6 %
LotionTopical10.4 %
Aerosol; lotionTopical4.86 %
LotionTopical4.1 %
Aerosol; lotionTopical3.9 %
CreamTopical1.26 g/50mL
LotionTopical4.82 %
CreamCutaneous1.6 mL/30mL
PowderTopical6.3 g/100g
CreamTopical17.5 %
PasteTopical17 %
LiquidTopical25.5 mg/1mL
EmulsionTopical29.2 mg/1mL
LiquidTopical29.2 mg/1mL
PowderTopical1.5 g/100g
CreamTopical3.5 g/100g
CreamTopical4.65 g/100g
CreamCutaneous0.81 g/45g
LotionTopical4 %
PowderTopical3984 mg/30000mg
PatchTopical0.001 g/30g
LotionTopical5.4 mg/100mg
PowderTopical2.381 g/10g
PowderTopical9.6 g/150mL
CreamTopical8.3 g/100g
LotionTopical45 mg/1mL
LotionTopical50 mg/1mL
EmulsionTopical68 mg
CreamTopical1.5 g
CreamTopical19 mg/1mL
LotionTopical4.8 %
LotionTopical6.83 %
LotionTopical4000 mg/50mL
LotionTopical110 mg/1mL
EmulsionTopical81 mg/1mL
LotionTopical81 mg/1mL
LotionTopical6.8 %
LotionTopical6 %
LiquidTopical156.752 mg/1mL
StickTopical0.002 g/3.5g
CreamTopical4.3 %
CreamTopical25 g/100g
CreamTopical3.8 g/100mL
CreamTopical2.05 mg/100mL
CreamTopical1.02 mg/50mL
CreamTopical0.5 mL/100mL
PowderTopical87 mg/1g
PowderTopical2 g/100g
LotionTopical1.809 mL/30mL
LotionTopical0.08 g/1g
Kit0.08 g/1g
LotionTopical82 mg/1mL
Kit82 mg/1mL
Not Available
Not Available


Experimental Properties
Not Available
Predicted Properties
pKa (Strongest Basic)-7.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area34.14 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity2.89 m3·mol-1ChemAxon
Polarizability4.19 Å3ChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available


Mass Spec (NIST)
Not Available
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available


This compound belongs to the class of inorganic compounds known as transition metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a transition metal.
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Transition metal organides
Sub Class
Transition metal oxides
Direct Parent
Transition metal oxides
Alternative Parents
Inorganic salts / Inorganic oxides
Transition metal oxide / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
titanium molecular entity (CHEBI:32234)


Pharmacological action
General Function
Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
Specific Function
Scavenger receptor activity
Gene Name
Uniprot ID
Uniprot Name
Macrophage receptor MARCO
Molecular Weight
52657.905 Da
  1. Thakur SA, Hamilton R Jr, Pikkarainen T, Holian A: Differential binding of inorganic particles to MARCO. Toxicol Sci. 2009 Jan;107(1):238-46. doi: 10.1093/toxsci/kfn210. Epub 2008 Oct 4. [PubMed:18836211]

Drug created on November 30, 2015 12:10 / Updated on January 22, 2019 17:57