Titanium dioxide

Identification

Summary

Titanium dioxide is a sunscreen agent found in sunscreens that absorbs UV rays.

Brand Names
Eucerin
Generic Name
Titanium dioxide
DrugBank Accession Number
DB09536
Background

Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium. It is used as a pigment under the names titanium white, Pigment White 6 (PW6), or CI 77891. It is typically extracted from ilmenite, rutile and anatase.

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 79.865
Monoisotopic: 79.937771
Chemical Formula
O2Ti
Synonyms
  • dióxido de titanio
  • óxido de titanio(4)
  • Titanium dioxide
External IDs
  • C.I. 77891
  • CI 77891
  • CI-77891
  • E 171
  • E-171
  • INS NO.171
  • INS-171
  • NSC-15204
  • NSC-200C

Pharmacology

Indication

Titanium dioxide is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide.

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatDermatitis, eczematousCombination Product in combination with: Witch hazel (DB11111), Ichthammol (DB11341), Zinc oxide (DB09321)••• •••••••••••
Used in combination for prophylaxis ofSunburn••• •••
Used in combination to treatWoundsCombination Product in combination with: Witch hazel (DB11111), Zinc oxide (DB09321), Ichthammol (DB11341)••• •••••••••••
Used in combination to treatAbrasionsCombination Product in combination with: Ichthammol (DB11341), Zinc oxide (DB09321), Witch hazel (DB11111)••• •••••••••••
Used in combination to treatBlisteringCombination Product in combination with: Ichthammol (DB11341), Zinc oxide (DB09321), Witch hazel (DB11111)••• •••••••••••
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

Diminish the penetration of ultraviolet (UV) light through the epidermis by absorbing UV radiation within a specific wavelength range. The amount and wavelength of UV radiation absorbed are affected by the molecular structure of the sunscreen agent.

TargetActionsOrganism
UMacrophage receptor MARCONot AvailableHumans
Absorption

When male and female rats were fed a diet containing titanium dioxide (100 g/kg) for a period of about 32 days, a significant retention of titanium of 0.06 and 0.11 mg/kg wet weight was found only in the muscles; no retention was observed in the liver, spleen, kidney, bone, plasma, or erythrocytes

Volume of distribution

Six hours after titanium dioxide was administered to rats through IV injection at 250 mg/kg body weight, the highest concentration appeared in the liver; after 24 hours, the highest concentration was detected in the celiac lymph nodes, which filter the lymph from the liver.

Protein binding

The researchers/ determined blood levels of titanium dioxide (anatase) following oral ingestion of titanium-dioxide capsules and/or powder in six adult men (24-66 years of age). Titanium dioxide was absorbed by the gastrointestinal tract in a size dependent manner: smaller particles (0.16 um) were more readily absorbed than larger ones (0.38 um). Before the experiment, the background blood levels of titanium dioxide in these men ranged from approximately 6 to 18 ug/L. Blood levels reached up to approximately 50 ug/L or 100 ug/L between 4 and 12 hours after intake of 23 mg or 46 mg titanium dioxide, respectively

Metabolism

Rats were intraperitoneal injected with 1.60 g/100 g body wt of TiO(2) in saline solution. Organs (liver, spleen, lung) were processed for histological evaluation. Reactive oxygen species (ROS) in alveolar macrophages obtained by bronchoalveolar lavage (BAL) were evaluated using the nitroblue tetrazolium test and quantitative evaluation by digital image analysis. The histological analysis of organs revealed the presence of titanium in the parenchyma of these organs with no associated tissue damage. Although in lung alveolar macrophages TiO(2) induced a significant rise in ROS generation, it failed to cause tissue alteration. This finding may be attributed to an adaptive response.

Route of elimination

The kinetics of TiO2 elimination in the rat lung following its deposition after 7 hr exposure at 10 and 50 mg/cu m were determined for periods up to 140 days.The retention half-time was 14 days for the first clearance phase and 88 days thereafter.

Half-life

The kinetics of TiO2 elimination in the rat lung following its deposition after 7 hr exposure at 10 and 50 mg/cu m were determined for periods up to 140 days...The retention half-time was 14 days for the first clearance phase and 88 days thereafter.

Clearance

The clearance of titanium dioxide from the lungs was studied in rats after inhalation of 15 or 100 mg/cu m. The average median aerodynamic diameter of the titanium dioxide particles was 1.48 um. After a single exposure, about 40-45% of the deposited particles were cleared from the lung in 25 days. At 15 mg/cu m, 0.7% was found in the hilar lymph nodes indicating penetration of titanium dioxide particles from alveoli into the lymphatic system and partial clearance by the lymphatic route. The clearance rate was similar after intra-tracheal administration of titanium dioxide. At an exposure of 100 mg/cu m, the clearance rate decreased drastically. /Other researchers/ demonstrated the presence of titanium dioxide in the lymphatic systems of 3 workers employed in processing titanium dioxide pigments.

Adverse Effects
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Toxicity

Rat - LD50 Intratracheal (>100ug/kg ) Effects: Structural or functional changes in bronchi and trachea. There is inadequate evidence in humans for the carcinogenicity of titanium dioxide. Cancer in experimental animals: There is sufficient evidence in experimental animals for the carcinogenicity of titanium dioxide. Overall evaluation: Titanium dioxide is possibly carcinogenic to humans (Group 2B).

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
PadeliporfinTitanium dioxide may increase the photosensitizing activities of Padeliporfin.
Porfimer sodiumTitanium dioxide may increase the photosensitizing activities of Porfimer sodium.
TretinoinThe risk or severity of adverse effects can be increased when Tretinoin is combined with Titanium dioxide.
VerteporfinTitanium dioxide may increase the photosensitizing activities of Verteporfin.
Food Interactions
No interactions found.

Products

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Active Moieties
NameKindUNIICASInChI Key
TitaniumunknownD1JT611TNE7440-32-6RTAQQCXQSZGOHL-UHFFFAOYSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
AV3712501 Mineral Sunscreen SPF 18Cream7.0 g/100gTopicalThe Hain Celestial Group2006-03-01Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
3 Concept Eyes Glossing Waterful Foundation Milk IvoryCream1.44 g/40gTopicalNanda Co., Ltd.2013-08-01Not applicableUS flag
3 Concept Eyes Glossing Waterful Foundation Natural IvoryCream1.44 g/40gTopicalNanda Co., Ltd.2013-08-01Not applicableUS flag
3 Concept Eyes Glossing Waterful Foundation Nude BeigeCream1.44 g/40gTopicalNanda Co., Ltd.2013-08-01Not applicableUS flag
3 Concept Eyes Glossing Waterful Foundation Soft BeigeCream1.44 g/40gTopicalNanda Co., Ltd.2013-08-01Not applicableUS flag
3 Concept Eyes Honey Face Chiffon Fluid 001Cream3.71 mg/40mLTopicalNanda Co., Ltd.2013-08-01Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
01 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
02 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
02 Cushion Spf45 SunscreenTitanium dioxide (13.5 g/100mL) + Octinoxate (5 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Zinc oxide (8 g/100mL)LiquidTopicalCOIZ CO LTD2019-06-30Not applicableUS flag
03 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
04 Balancing Foundation SPF 15Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Abalone Crystaldouble EX BbTitanium dioxide (9.9 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Octinoxate (2 g/100mL) + Octocrylene (3 g/100mL)CreamTopicalC&bcosmetic Co.,ltd.2017-03-10Not applicableUS flag
Abalone Crystaldouble EX CcTitanium dioxide (4.694 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Octinoxate (7 g/100mL)CreamTopicalC&bcosmetic Co.,ltd.2017-03-10Not applicableUS flag
AHC Premium Intense Contour BalmTitanium dioxide (3.96 g/50mL) + Adenosine (0.02 g/50mL) + Aluminium tristearate (0.04 g/50mL) + Aluminum hydroxide (0.45 g/50mL) + Arbutin (1 g/50mL) + Methicone (20 CST) (1.3 g/50mL) + Octinoxate (1.5 g/50mL) + Talc (2.05 g/50mL) + Zinc oxide (0.96 g/50mL)CreamTopicalCarver Korea Co.,Ltd.2014-01-152017-11-22US flag
Antibacterial PE filmTitanium dioxide (0.3 g/100g)FilmTopicalDH Investment Co Ltd2020-06-27Not applicableUS flag
Beaute de Cell Perfect Sun-Shield SPF 50 PATitanium dioxide (3.85 g/100mL)CreamTopicalDracell Cosmetics Co., Ltd2016-02-04Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as transition metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Transition metal organides
Sub Class
Transition metal oxides
Direct Parent
Transition metal oxides
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Inorganic oxide / Inorganic salt / Transition metal oxide
Molecular Framework
Not Available
External Descriptors
titanium molecular entity (CHEBI:32234)
Affected organisms
Not Available

Chemical Identifiers

UNII
15FIX9V2JP
CAS number
13463-67-7
InChI Key
GWEVSGVZZGPLCZ-UHFFFAOYSA-N
InChI
InChI=1S/2O.Ti
IUPAC Name
dioxotitanium
SMILES
O=[Ti]=O

References

General References
  1. Olmedo DG, Tasat DR, Guglielmotti MB, Cabrini RL: Effect of titanium dioxide on the oxidative metabolism of alveolar macrophages: an experimental study in rats. J Biomed Mater Res A. 2005 May 1;73(2):142-9. [Article]
  2. Drugs.com [Link]
  3. ChemIDplus [Link]
  4. Pubchem [Link]
KEGG Compound
C13409
PubChem Compound
26042
PubChem Substance
347827875
ChemSpider
24256
RxNav
38323
ChEBI
32234
Wikipedia
Titanium_dioxide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedNot AvailableSunburn1
4CompletedTreatmentMelasma1
3CompletedTreatmentCaries / Caries Class I / Dental Decay / Dentin Caries / Pulpitis - Reversible / Pulpitis dental1
3Unknown StatusTreatmentBleeding / Infection / Postoperative Complications1
2CompletedSupportive CareAdvanced Malignant Neoplasm / Dermatologic Complications1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CreamTopical1.44 g/40g
CreamTopical3.71 mg/40mL
CreamTopical2.78 mg/30mL
PowderTopical0.57 g/8g
LipstickTopical0.02 g/4.5g
LipstickTopical0.11 g/4.5g
LipstickTopical0.15 g/4.5g
LipstickTopical0.16 g/4.5g
LipstickTopical0.17 g/4.5g
LipstickTopical0.22 g/4.5g
LipstickTopical0.13 g/4.5g
LipstickTopical0.03 g/4.5g
LipstickTopical0.18 g/4.5g
LipstickTopical0.09 g/4.5g
LipstickTopical0.01 g/1.1g
LipstickTopical0.23 g/1.1g
LipstickTopical0.26 g/1.1g
LipstickTopical0.04 g/1.1g
LipstickTopical0.22 g/1.1g
LipstickTopical0.08 g/1.1g
PowderTopical0.07 g/5g
PowderTopical0.31 g/5g
PowderTopical0.37 g/5g
PowderTopical0.12 g/5g
PowderTopical0.67 g/8g
PowderTopical0.68 g/8g
PowderTopical0.47 g/8g
PowderTopical0.52 g/8g
LiquidTopical0.16 g/6g
LiquidTopical0.19 g/6g
LiquidTopical0.06 g/6g
LiquidTopical0.65 g/5mL
LipstickTopical0.02 g/3.5g
LipstickTopical0.12 g/3.5g
LipstickTopical0.05 g/3.5g
LipstickTopical0.17 g/3.5g
LipstickTopical0.04 g/3.5g
LipstickTopical0.07 g/3.5g
LipstickTopical0.10 g/3.5g
LipstickTopical0.20 g/3.5g
LipstickTopical0.15 g/3.5g
LipstickTopical0.29 g/3.5g
LipstickTopical0.14 g/3.5g
LipstickTopical0.13 g/3.5g
LipstickTopical0.014 g/3.5g
LipstickTopical0.010 g/3.5g
LipstickTopical0.01 g/3.5g
PowderTopical1.03 g/11g
PowderTopical1.63 g/11g
LipstickTopical0.129 g/1g
LipstickTopical0.03 g/1g
LipstickTopical0.097 g/1g
LipstickTopical0.107 g/1g
LipstickTopical0.005 g/1g
LipstickTopical0.11 g/1g
LipstickTopical0.081 g/1g
PowderTopical0.12 g/25g
StickTopical0.47 g/10g
StickTopical0.4 g/10g
StickTopical0.85 mg/0.085g
StickTopical0.015 g/0.085g
StickTopical0.017 g/0.085g
StickTopical0.005 g/0.085g
PowderTopical0.42 g/3.5g
PowderTopical0.30 g/3.5g
PowderTopical0.36 g/3.5g
PowderTopical0.23 g/3.5g
CreamTopical78.6 mg/1mL
CreamTopical121.6 mg/1mL
CreamTopical77.2 mg/1mL
PowderTopical0.387 g/4.3g
CreamTopical5 %
LotionTopical2.4 %
LiquidTopical11.18 g/140mL
CreamTopical1.8 %
PowderTopical1.7 g/12g
Emulsion; kitTopical
CreamTopical9.072 g/40g
CreamTopical1.7 g/7.5g
LotionTopical42 mg/1mL
SprayTopical
CreamTopical2.46 g/30mL
StickTopical0.234 g/100g
StickTopical8.8 %
LiquidTopical8.9 %
PowderTopical9.8 g/100g
LiquidTopical45 mL/100mL
CreamTopical6.4 %
CreamTopical8 %
CreamTopical7.3 %
CreamTopical7.6 %
PowderTopical6.9 g/100g
CreamTopical1.72 g/50g
CreamTopical2.6 g/50g
CreamTopical115.2 mg/1mL
FilmTopical0.3 g/100g
CreamTopical0.0934 g/1g
CreamCutaneous4.64 mL/50mL
CreamTopical40.25 mg/1mL
LiquidTopical7.5 %
StickTopical1.41 g/16g
CreamTopical7.0 g/100g
CreamTopical4.4 %
CreamTopical18.8 mg/1mL
CreamTopical4.8 %
CreamTopical2.5 %
StickTopical2.5 %
LotionTopical2.2 %
LotionTopical6.48 %
LotionTopical8.1 %
LotionTopical9.72 %
LotionTopical6 g/100mL
CreamTopical8.46 g/100g
CreamTopical170 mg/1mL
LotionTopical60 mg/1mL
LiquidTopical33.2 mg/1mL
LiquidTopical110 mg/1mL
LiquidTopical0.065 g/10mL
LiquidTopical62 mg/1mL
StickTopical415 mg/10g
GelTopical62 mg/1mL
PowderTopical25 g/100g
PoulticeTopical
PowderTopical488 mg/2g
PowderTopical12 g/100g
PowderTopical2000 mg/8g
LiquidTopical0.747 mg/1mL
CreamTopical0.3 g/2g
CreamTopical0.1 g/2g
PowderTopical20 g/100g
CreamTopical3.42 g/30mL
CreamTopical3.85 g/100mL
LiquidTopical0.038 mg / g
ClothTopical0.56 g/301
PowderTopical8.56 g/100g
CreamTopical3.25 g/35mL
CreamTopical3.69 g/40g
OilTopical18 mg/1mL
CreamTopical159 mg/1mL
PowderTopical24 g/100g
CreamTopical4.33 %
LotionTopical10.145 %
CreamTopical69 mg/1mL
LotionTopical3.75 mg/50mL
CreamTopical6.45 g/100g
CreamTopical6.4 g/100g
CreamTopical12.1 mg/100mL
PowderTopical6 g/100g
PowderTopical8.4 g/100g
PowderTopical11.4072 g/100g
LotionTopical5 g/100mL
CreamTopical15.8 g / 100 g
CreamTopical19.8 g / 100 g
LiquidTopical6.2 g / 100 g
LiquidTopical5.7 g / 100 g
LiquidTopical7.7 g / 100 g
LiquidTopical8.2 g / 100 g
LiquidTopical8.4 g / 100 g
LiquidTopical7.5 g / 100 g
PowderTopical7.3 g / 100 g
PowderTopical7 g / 100 g
PowderTopical6.2 g / 100 g
PowderTopical11.1 g / 100 g
PowderTopical5.6 g / 100 g
CreamTopical2.3 g/100mL
LotionTopical501 mg/6g
LotionTopical930 mg/6g
CreamTopical9.8525 g/100mL
PowderTopical0.89 g/5g
PowderTopical0.98 g/5g
PowderTopical0.55 g/5g
PowderTopical0.67 g/5g
PowderTopical0.28 g/5g
SolutionTopical
CreamTopical120 mg/1mL
CreamTopical8.5 g/100mL
CreamTopical36.5 mg/1mL
PowderTopical2.10 g/14g
LotionTopical10.157 g/100g
LotionTopical10.622 g/100g
CreamTopical106.22 mg/1g
CreamTopical5.8 %
PasteTopical5.8 g/100g
CreamTopical11.2 %
CreamTopical8.8 %
CreamTopical8.2 %
CreamTopical14.85 %
CreamTopical9.9 %
PowderTopical15 g/100g
StickTopical10.0 %
StickTopical4 %
StickTopical4.0 g/100g
StickTopical7.5 %
LiquidTopical28 mg/1mL
CreamTopical47 mg/1mL
LiquidTopical47 mg/1mL
LiquidTopical20 mg/1mL
LiquidTopical25 mg/1mL
CreamTopical70 mg/1mL
CreamTopical68 mg/1mL
CreamTopical63 mg/1mL
CreamTopical23 mg/1mL
EmulsionTopical62 mg/1mL
EmulsionTopical28 mg/1mL
LiquidTopical19 mg/1mL
EmulsionTopical30 mg/1mL
SolutionTopical94.5 mg/1mL
CreamTopical84 mg/1mL
CreamTopical28 mg/1mL
SolutionTopical18.9 mg/1mL
LiquidTopical18.9 mg/1mL
CreamTopical81 mg/1mL
LiquidTopical81 mg/1mL
LiquidTopical70 mg/1mL
SolutionTopical70 mg/1mL
SolutionTopical81 mg/1mL
StickTopical80 mg/5g
PasteTopical684 mg/12g
PasteTopical1.896 g/12g
CreamTopical0.65625 g/31.25g
CreamTopical656 mg/31.25g
EmulsionTopical2.72118 g/35mL
CreamTopical3960 mg/40g
StickTopical1.31 g/8g
PowderTopical12.1 %
CreamTopical24 %
CreamTopical13.8 %
PowderTopical2.4 g/21g
PowderTopical0.87 g/6.25g
CreamTopical1.26 g/30g
PowderTopical4.2 %
CreamTopical75 mg/1mL
CreamTopical0.0273 g/1mL
CreamTopical2.0 mL/100mL
CreamTopical20 %
SuspensionTopical11.8 %
SuspensionTopical8.5 %
SuspensionTopical4.0 %
LiquidTopical1.80 g/15mL
CreamTopical1.00 g/4.2g
CreamTopical1.49 g/6.5g
CreamTopical1.52 g/6.5g
LipstickTopical1.8 g/100g
CreamTopical9 g/100g
CreamTopical4.9 mg/0.1g
CreamTopical49 mg/1g
CreamTopical4.95 g/100mL
CreamTopical17 mg/100mg
GelTopical7.8 mL/100mL
CreamTopical3.225 %
LotionTopical2 %
CreamTopical50 mg/1mL
CreamTopical30 mg/1g
LotionTopical10 mg/1mL
LotionTopical104 mg/1mL
LotionTopical9.7 mg/1mL
LotionTopical68 mg/1mL
LotionTopical61 mg/1mL
PowderTopical3 %
CreamTopical71 mg/1mL
LotionTopical210 mg/2mL
PowderTopical5.53 g/100g
CreamTopical21.9 mg/1mL
CreamTopical1 mg/1mL
AerosolTopical
CreamTopical1.38 g/50mL
CreamTopical2.905 g/100mL
PowderTopical7 g/100g
LiquidTopical99 mg/1mL
PowderTopical5.8 %
PowderTopical0.494 g/13g
LiquidTopical5.0 mL/100mL
CreamTopical14 mg/1mL
PowderTopical2.2 g/100g
LiquidTopical4.2 mL/100mL
LiquidTopical1.0 mL/100mL
PowderTopical4.0 g/100g
CreamTopical10.08 g/100g
CreamCutaneous4.2 mg/100mg
LiquidCutaneous
CreamTopical4.05 g/50g
LotionTopical2.14 g/60mL
LotionTopical5 g/100g
PowderTopical1.80 g/15g
CreamTopical9 %
PowderTopical4 g/100g
PowderTopical
CreamTopical80 mg/1g
LotionTopical2 mL/100mL
LotionTopical189.16 mg/1mL
LotionTopical192.39 mg/1mL
StickTopical0.04 g/1g
CreamCutaneous3.5 g/35g
PowderTopical3.7 %
LiquidTopical3.5 %
LotionTopical7.2 %
LotionTopical12 %
SuspensionTopical3 %
PowderTopical10 g/100g
CreamTopical3.8 g/100g
CreamTopical19 mg/1mL
CreamTopical2.075 g/100g
StickTopical5 g / 100 g
LotionTopical53.9 mg/1mL
LiquidTopical97 mg/1mL
LiquidTopical83 mg/1mL
LiquidTopical84 mg/1mL
LiquidTopical78 mg/1mL
LotionTopical4.03 g / g
CreamTopical5.6601 g/100mL
CreamTopical4.2 g/100mL
CreamTopical10 mL/100mL
OilTopical5 g/100mL
CreamTopical35 mg/1mL
CreamTopical40 mg/1mL
CreamTopical5 g/100mL
CreamTopical7.5 g/100mL
CreamTopical1.3500 g/45.0000g
CreamTopical3 g/100g
CreamTopical3.1500 g/45.0000g
CreamTopical7 g/100g
CreamTopical3.1680 g/45.0000g
CreamTopical6.8 %
CreamTopical3.4 %
PasteTopical4.2 g/100g
CreamCutaneous4.01 mL/35mL
CreamCutaneous2.35 g/10g
PowderCutaneous2.35 g/10g
StickTopical20 mg/1g
LiquidTopical4 %
StickTopical23 g/100g
EmulsionTopical10.4 %
EmulsionTopical5.68 %
LotionTopical15.9 g/100mL
EmulsionTopical6.37 %
PowderTopical1.96 g/100g
LotionTopical0.504 g/12g
LotionTopical30 mg/1mL
CreamTopical20.78 %
LiquidTopical29.2 mg/1mL
StickCutaneous
CreamTopical2.886 g/60g
CreamCutaneous1.77 mg/100mL
CreamTopical765 mg/9g
LotionTopical41.1 mg/1mL
CreamTopical124 mg/1mL
CreamTopical73 mg/1mL
CreamTopical2.478 g/59g
LiquidOral2 g/100mL
CreamCutaneous4.48 g/45g
PatchTopical
PowderTopical5 %
CreamTopical54 mg/1mL
LotionTopical25.8 mg/1mL
LotionTopical37.4 mg/1mL
LotionTopical1.78 g/50mL
LotionTopical1.785 g/50mL
LotionTopical1.784 g/40mL
PowderTopical10.5 g/100g
CreamTopical0.38 mg/45mL
Kit; stickTopical
LiquidTopical0.1 g/20L
CreamTopical1.5 g/50g
Cream, augmentedTopical
OilTopical
LotionTopical120 mg/1g
LotionTopical78.5 mg/1mL
LotionTopical150 mg/1mL
Spray, suspensionTopical7.8 g/100mL
SprayTopical0.078 mg/1mL
SprayTopical78 mg/1mL
LiquidTopical5 %
PowderTopical1.179423 g/9g
PowderTopical0.895536 g/9g
PowderTopical0.9558 g/12g
PowderTopical13.1 g/100g
CreamTopical86.4 mg/1mL
LotionTopical6.5 g/100g
LotionTopical250 mg/1mL
CreamTopical106.6 mg/1mL
CreamTopical155 mg/1mL
CreamTopical11 %
CreamTopical2.4 g/30g
LipstickTopical
PowderTopical0.05 g/1g
PowderTopical0.55 g/11g
Lotion / shampooTopical
EmulsionTopical17.6 mg/1mL
LotionTopical8 %
EmulsionTopical70 mg/1mL
CreamTopical2.522 g/25mL
LiquidTopical2.31 g/20mL
LiquidTopical3.09 g/30mL
CreamTopical115.2 g/1mL
CreamTopical153.2 mg/1mL
CreamTopical154.3 mg/1mL
CreamTopical151.4 mg/1mL
CreamTopical5.35 g/100mL
PowderTopical3.0 %
PowderTopical100 mg/1g
LiquidTopical32.6 mg/1mL
CreamTopical61 mg/1g
CreamTopical12.1 g/100g
PowderCutaneous0.92 g/13g
CreamTopical11.8 g / 100 g
CreamTopical5.269 g/100mL
SuspensionTopical
LotionTopical33.9 mg/1mL
LotionTopical46.3 mg/1mL
SprayTopical4.9 %
EmulsionTopical60 mg/1mL
CreamTopical31.6 mg/1mL
LotionTopical2.7 %
CreamTopical19.90 mL/100mL
PowderTopical5.77 g/100g
CreamTopical11.5 mg/1mL
LotionTopical15.3 mg/1mL
StickTopical
GelTopical
ShampooTopical3 g/100mL
CreamTopical80 mg/1mL
LotionTopical70 mg/1mL
CreamTopical2 %
LotionTopical11.3 g/100mL
LotionTopical4.2 g/100mL
LotionTopical0.04601 g/1mL
LotionTopical4.30 mL/100mL
CreamTopical16 g/100g
PowderTopical7.0 g/100g
CreamCutaneous7.5 mg/1g
CreamCutaneous3.77 mL/50mL
CreamCutaneous9.3 mg/1g
PowderCutaneous0.98 g/11g
CreamCutaneous3.5 mL/50mL
CreamCutaneous3.57 mL/50mL
CreamTopical2.28 g/10g
CreamTopical4 %
LotionTopical5.4 mL/100mL
CreamTopical1 g/100mL
CreamTopical5.9 g/100mL
CreamCutaneous1.19 mL/35mL
PowderCutaneous
LiquidTopical
CreamTopical12 %
LotionTopical750 mg/118mL
CreamCutaneous1.36 mL/50mL
LiquidTopical1.98 g/17g
CreamTopical0.1175 1/50mL
CreamTopical5.85 g/50mL
CreamCutaneous1.45 mL/50mL
CreamTopical95 mg/1g
CreamTopical92 mg/1g
CreamTopical25.2 mg/1g
CreamTopical18.8 mg/1g
CreamTopical36 mg/1mL
LiquidTopical24 mg/1mL
LiquidTopical66 mg/1mL
PowderTopical75 mg/1g
PowderTopical41.1 mg/1g
LotionTopical28 mg/1mL
LotionTopical29 mg/1mL
LiquidTopical32 mg/1mL
LotionTopical9.1 %
LotionTopical7.25 %
CreamTopical20 mg/1mL
LotionTopical480 mg/1mL
EmulsionTopical
LotionTopical80 mg/1mL
LotionTopical130 mg/1mL
LotionTopical120 mg/1mL
LotionTopical90 mg/1mL
CreamTopical77 mg/1mL
LotionTopical7.6 mL/100mL
PowderTopical2.1 g/100g
LiquidTopical2.4 mL/100mL
CreamCutaneous1.18 mL/60mL
CreamCutaneous2.10 mL/60mL
CreamTopical121.6 mg/1g
Kit; liquid; lotionTopical
CreamTopical88 mg/88mL
LotionTopical88 mg/1mL
EmulsionTopical0.65 g/1g
EmulsionTopical0.66 g/1g
EmulsionTopical85 mg/1g
EmulsionTopical100.8 mg/1g
LotionTopical22 %
CreamTopical0.8 g/35mL
CreamTopical0.87 mL/35mL
CreamTopical3.95 g/100g
LotionTopical102 mg/1mL
LotionTopical76.5 mg/1mL
LotionCutaneous
CreamTopical2.94 g/70mL
CreamTopical120 mg/1g
PowderTopical2.06 g/12g
CreamTopical39 mg/1mL
EmulsionTopical31 mg/1mL
LotionTopical0.2625 mg/2.5mL
CreamTopical7.2 g / 100 g
CreamTopical1.52 g/7g
CreamCutaneous3.25 mL/35mL
CreamCutaneous
CreamCutaneous1.68 g/12g
PowderCutaneous1.68 g/12g
CreamTopical3.26 g/35mL
LotionTopical8.8 g/100mL
LiquidTopical4.7 mL/100mL
PowderTopical8.0 %
CreamTopical16 %
CreamTopical0.02 g/20g
CreamTopical4 mg/100mL
LotionTopical4 g/100mL
LotionTopical4.7 mL/100mL
PowderTopical0.24 g/10g
PowderTopical0.21 g/1g
PowderTopical0.07 g/1g
PowderTopical2.38 g/10g
PowderTopical1.43 g/6g
PowderTopical0.358 g/8.33g
PowderTopical0.72 g/8g
PowderTopical0.38 g/4.25g
CreamTopical6 mg/100mL
CreamTopical2.6 mg/100mL
CreamTopical2.96 mg/100mL
CreamCutaneous2.59 g/50g
PowderTopical0.84 g/12g
CreamTopical1.4 mL/100mL
Kit; lotionTopical
CreamTopical956.25 mg/4.25g
LotionTopical4 g/100g
CreamCutaneous2.32 g/25g
LotionTopical0.024 mg/1mL
CreamTopical12.5 %
PowderTopical2 %
CreamTopical11.5 %
LiquidTopical7.4 %
LiquidTopical5.2 %
StickTopical4.8 %
LiquidTopical6 %
LiquidTopical8.60 %
PowderTopical11.00 %
PowderTopical14.3 %
PowderTopical3.5 %
PasteTopical4 mg/1mL
CreamTopical52.8 mg/1mL
CreamTopical61.6 mg/1mL
CreamTopical9.1 %
LotionTopical5.6 g/100mL
LiquidTopical5.6 g/100mL
CreamTopical0.5 g/100g
CreamTopical100 mg/1mL
LotionTopical40 uL/1mL
LotionTopical2.91 mg/30mL
CreamTopical6.96 %
LotionTopical2.866 g/44.4mL
PowderTopical12.9 g/100g
CreamTopical4 g/100mL
LiquidTopical13 g/100mL
CreamTopical2.25 g/13g
CreamTopical42 mg/1mL
LiquidTopical5 g/100mL
CreamTopical
PowderTopical0.54 g/12g
PowderTopical540 mg/12g
PowderTopical864 mg/12g
PowderTopical22.7 %
PowderTopical24.6 %
CreamTopical10.7 %
EmulsionTopical12.7 %
EmulsionTopical11.45 %
EmulsionTopical11.1 %
CreamTopical1488 mg/36.3g
LiquidTopical13.9 %
StickTopical250 mg/10g
StickTopical400 mg/10g
StickTopical410 mg/10g
Aerosol, foamTopical
StickTopical0.60 g/9g
StickTopical0.55 g/9g
StickTopical208 mg/1g
CreamTopical0.04 g/5.5g
CreamTopical13 g/13g
Cream; kitTopical
LotionTopical6.7 g/100g
Cream; kit; liquidTopical
LotionTopical54.9 mg/1mL
LotionTopical6.90 g/100mL
KitTopical
PowderTopical3 g/100g
PowderOral
CreamTopical9.7 %
CreamTopical8.86 %
CreamTopical3.1 g / 100 g
PowderTopical0.7 g/10g
Lotion / shampooTopical80 mg/1mL
LiquidTopical2.9445 g/44.4mL
LotionTopical8.46 %
StickTopical3.3 g/100mL
Spray, suspensionTopical
CreamCutaneous; Topical
StickTopical170 mg/1g
Lotion / shampooTopical120 mg/1g
Aerosol, sprayTopical
PowderTopical4.5 %
LotionTopical1 g/66mL
LotionTopical1 g/88mL
CreamTopical12 mg/1mL
PasteTopical
SpongeTopical
CreamTopical8.1 %
CreamTopical9.72 %
LotionTopical10 %
LotionTopical
LotionTopical5.67 %
CreamTopical6.1 %
CreamTopical3.9 %
CreamTopical8.9 %
CreamTopical6.5 %
LotionTopical5.6 %
LotionTopical10.4 %
Aerosol; lotionTopical4.86 %
LotionTopical4.1 %
Kit; lotion; stickTopical
Aerosol; lotionTopical3.9 %
CreamTopical1.26 g/50mL
LotionTopical4.82 %
CreamCutaneous1.6 mL/30mL
CreamTopical25 mg/1mL
CreamTopical74 mg/1mL
PowderTopical6.3 g/100g
CreamTopical17.5 %
PasteTopical17 %
LiquidTopical25.5 mg/1mL
EmulsionTopical29.2 mg/1mL
PowderTopical1.5 g/100g
CreamTopical7.99 mg/100mL
CreamTopical88 mg/1mL
CreamTopical3.5 g/100g
CreamTopical4.65 g/100g
CreamCutaneous0.81 g/45g
LotionTopical4 %
PowderTopical1510 mg/11000mg
PowderTopical3984 mg/30000mg
PatchTopical0.001 g/30g
LiquidNot applicable1 kg/1kg
CreamTopical99 mg/1mL
LotionTopical5.4 mg/100mg
PowderTopical2.381 g/10g
CreamTopical8.3 g/100g
LotionTopical45 mg/1mL
LotionTopical50 mg/1mL
CreamTopical10.4 g/100g
Cream; kit; lotionTopical
EmulsionTopical68 mg / mL
CreamTopical1.5 g / 100 g
LotionTopical4.8 %
LotionTopical6.83 %
LotionTopical4000 mg/50mL
LotionTopical110 mg/1mL
CreamTopical74.7 mg/1mL
EmulsionTopical81 mg/1mL
LotionTopical81 mg/1mL
PowderNot applicable0.73 kg/1kg
PowderNot applicable0.83 kg/1kg
PowderNot applicable0.8 kg/1kg
PowderNot applicable0.82 kg/1kg
PowderNot applicable0.81 kg/1kg
PowderNot applicable0.93 kg/1kg
PowderNot applicable0.92 kg/1kg
PowderNot applicable0.85 kg/1kg
PowderNot applicable0.88 kg/1kg
OintmentTopical
LotionTopical6.8 %
OintmentTopical6 % w/w
LotionTopical6 %
StickTopical24.15 g/100g
LotionTopical148 mg/1mL
LiquidTopical156.752 mg/1mL
EmulsionTopical64 mg/1mL
CreamTopical2.48 g/59g
StickTopical0.002 g/3.5g
CreamTopical4.3 %
CreamTopical25 g/100g
CreamTopical3.8 g/100mL
CreamTopical2.05 mg/100mL
CreamTopical1.02 mg/50mL
CreamTopical0.5 mL/100mL
PowderTopical87 mg/1g
SoapTopical
PowderTopical2 g/100g
LotionTopical60.3 mg/1mL
LotionTopical0.08 g/1g
KitTopical0.08 g/1g
KitTopical82 mg/1mL
Kit; lotionTopical82 mg/1mL
LotionTopical82 mg/1mL
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.7Chemaxon
pKa (Strongest Basic)-7.7Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area34.14 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity2.89 m3·mol-1Chemaxon
Polarizability4.19 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
Specific Function
Scavenger receptor activity
Gene Name
MARCO
Uniprot ID
Q9UEW3
Uniprot Name
Macrophage receptor MARCO
Molecular Weight
52657.905 Da
References
  1. Thakur SA, Hamilton R Jr, Pikkarainen T, Holian A: Differential binding of inorganic particles to MARCO. Toxicol Sci. 2009 Jan;107(1):238-46. doi: 10.1093/toxsci/kfn210. Epub 2008 Oct 4. [Article]

Drug created at November 30, 2015 19:10 / Updated at March 18, 2024 16:48