You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameColchicine
Accession NumberDB01394
TypeSmall Molecule
GroupsApproved
DescriptionA major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (periodic disease). [PubChem]
Structure
Thumb
Synonyms
Colchicin
Colchicina
Colchicinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ColchicineTablet0.6 mgOralSandoz Canada Incorporated1974-12-31Not applicableCanada
ColchicineTablet, film coated.6 mg/1OralPrasco Laboratories2015-01-12Not applicableUs
ColchicineCapsule.6 mg/1OralWest Ward Pharmaceuticals Corp2014-10-01Not applicableUs
ColchicineTablet1 mgOralEuro Pharm International Canada Inc1950-12-312012-06-14Canada
Colchicine Tab 0.6mgTablet0.6 mgOralD.C. Labs Limited1969-12-312003-07-11Canada
Colchicine Tab 0.6mgTablet0.6 mgOralAbbott Laboratories, Limited1951-12-312007-07-31Canada
Colchicine Tab 0.6mgTablet0.6 mgOralOdan Laboratories Ltd1982-12-31Not applicableCanada
Colchicine Tab 1mgTablet1 mgOralOdan Laboratories Ltd1985-12-312013-03-06Canada
ColcrysTablet, film coated.6 mg/1OralProficient Rx LP2009-09-01Not applicableUs
ColcrysTablet, film coated.6 mg/1OralAR Scientific Inc.2009-09-01Not applicableUs
ColcrysTablet, film coated.6 mg/1OralPhysicians Total Care, Inc.2011-10-19Not applicableUs
ColcrysTablet, film coated.6 mg/1OralTakeda Pharmaceuticals America, Inc.2009-09-01Not applicableUs
ColcrysTablet, film coated.6 mg/1OralAphena Pharma Solutions Tennessee, Llc2009-09-01Not applicableUs
ColcrysTablet, film coated.6 mg/1OralCardinal Health2009-09-01Not applicableUs
ColcrysTablet, film coated.6 mg/1OralREMEDYREPACK INC.2013-02-212016-04-05Us
ColcrysTablet, film coated.6 mg/1OralREMEDYREPACK INC.2013-05-032016-04-05Us
ColcrysTablet, film coated.6 mg/1OralAvera Mc Kennan Hospital2015-08-05Not applicableUs
Euro-colchicineTablet0.6 mgOralEuro Pharm International Canada IncNot applicableNot applicableCanada
Jamp-colchicineTablet0.6 mgOralJamp Pharma Corporation2011-10-07Not applicableCanada
Jamp-colchicineTablet1.0 mgOralJamp Pharma Corporation2011-10-072013-04-03Canada
MitigareCapsule.6 mg/1OralHikma Americas, Inc.2014-10-01Not applicableUs
PMS-colchicineTablet0.6 mgOralPharmascience Inc2013-02-27Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ColchicineTablet.6 mg/1OralAmneal Pharmaceuticals of New York, LLC2016-09-30Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Probenecid and ColchicineWatson Laboratories, Inc.
Verban OntWelcker Lyster Ltd., Division Of Technilab Inc.
SaltsNot Available
Categories
UNIISML2Y3J35T
CAS number64-86-8
WeightAverage: 399.437
Monoisotopic: 399.168187537
Chemical FormulaC22H25NO6
InChI KeyIAKHMKGGTNLKSZ-UHFFFAOYSA-N
InChI
InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)
IUPAC Name
N-{3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0²,⁷]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl}acetamide
SMILES
COC1=CC2=C(C(OC)=C1OC)C1=CC=C(OC)C(=O)C=C1C(CC2)NC(C)=O
Pharmacology
IndicationFor treatment and relief of pain in attacks of acute gouty arthritis.
Structured Indications
PharmacodynamicsColchicine is a highly poisonous alkaloid, originally extracted from plants of the genus Colchicum (Autumn crocus, also known as the "Meadow saffron"). Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition.
Mechanism of actionThe precise mechanism of action has not been completely established. In patients with gout, colchicine apparently interrupts the cycle of monosodium urate crystal deposition in joint tissues and the resultant inflammatory response that initiates and sustains an acute attack. Colchicine decreases leukocyte chemotaxis and phagocytosis and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals. Colchicine also inhibits urate crystal deposition, which is enhanced by a low pH in the tissues, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Colchicine has no analgesic or antihyperuricemic activity. Colchicine inhibits microtubule assembly in various cells, including leukocytes, probably by binding to and interfering with polymerization of the microtubule subunit tubulin. Although some studies have found that this action probably does not contribute significantly to colchicine's antigout action, a recent in vitro study has shown that it may be at least partially involved.
TargetKindPharmacological actionActionsOrganismUniProt ID
Tubulin beta-1 chainProteinyes
inhibitor
HumanQ9H4B7 details
Tubulin beta chainProteinyes
inhibitor
HumanP07437 details
Related Articles
AbsorptionColchicine is rapidly absorbed after oral administration, probably from the jejunum and ileum. However, the rate and extent of absorption are variable, depending on the tablet dissolution rate; variability in gastric emptying, intestinal motility, and pH at the absorption site; and the extent to which colchicine is bound to microtubules in gastrointestinal mucosal cells.
Volume of distribution
  • 5 to 8 L/kg [healthy young volunteers]
Protein bindingLow to moderate (30 to 50%).
Metabolism

Probably hepatic. Although colchicine metabolites have not been identified in humans, metabolism by mammalian hepatic microsomes has been demonstrated in vitro.

Route of eliminationIn healthy volunteers (n=12) 40 – 65% of 1 mg orally administered colchicine was recovered unchanged in urine. Enterohepatic recirculation and biliary excretion are also postulated to play a role in colchicine elimination.
Half lifeElimination half-life is approximately 1 hour in healthy subjects, although a study with an extended sampling time reported mean terminal elimination half-life values of approximately 9 to 10.5 hours. Other studies have reported half-life values of approximately 2 hours in patients with alcoholic cirrhosis and approximately 2.5 hours in patients with familial Mediterranean fever.
Clearance
  • 0.17 L/hr/kg [familial Mediterranean fever patients with end-stage renal disease]
  • 0.73 L/hr/kg [familial Mediterranean fever patients with normal renal function]
ToxicityThe onset of toxic effects is usually delayed for several hours or more after the ingestion of an acute overdose. Nausea, vomiting, abdominal pain, and diarrhea occur first. The diarrhea may be bloody due to hemorrhagic gastroenteritis. Burning sensations of the throat, stomach, and skin may be prominent symptoms. Extensive vascular damage may result in shock. Kidney damage, evidenced by hematuria and oliguria, may occur. Muscular weakness may be marked, and ascending paralysis of the central nervous system may develop; the patient usually remains conscious. Delirium and convulsions may occur. Death due to respiratory arrest may result. Although death from the ingestion of as little as 7 mg has been reported, much larger doses have been survived .
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Colchicine.Approved
AcetaminophenThe serum concentration of Colchicine can be increased when it is combined with Acetaminophen.Approved
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Colchicine.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Colchicine.Approved, Vet Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Colchicine.Approved
AlbendazoleThe serum concentration of Colchicine can be increased when it is combined with Albendazole.Approved, Vet Approved
AldosteroneThe serum concentration of Colchicine can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Colchicine can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Colchicine can be increased when it is combined with Alfentanil.Approved, Illicit
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Colchicine.Approved, Investigational
AmantadineThe serum concentration of Colchicine can be increased when it is combined with Amantadine.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Colchicine.Approved, Investigational
Aminohippuric acidThe serum concentration of Colchicine can be increased when it is combined with Aminohippuric acid.Approved
AmiodaroneThe serum concentration of Colchicine can be increased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Colchicine can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Colchicine can be increased when it is combined with Amlodipine.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Colchicine.Approved
AmprenavirThe serum concentration of Colchicine can be increased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Colchicine can be increased when it is combined with Amsacrine.Approved
AnvirzelAnvirzel may decrease the cardiotoxic activities of Colchicine.Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Colchicine.Approved
AprepitantThe serum concentration of Colchicine can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Colchicine.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Colchicine.Approved, Investigational
AstemizoleThe serum concentration of Colchicine can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe serum concentration of Colchicine can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Colchicine can be increased when it is combined with Atenolol.Approved
AtomoxetineThe serum concentration of Colchicine can be increased when it is combined with Atomoxetine.Approved
AtorvastatinColchicine may increase the myopathic rhabdomyolysis activities of Atorvastatin.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Colchicine.Approved, Investigational
AzelastineThe serum concentration of Colchicine can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Colchicine can be increased when it is combined with Azithromycin.Approved
BenzocaineThe serum concentration of Colchicine can be increased when it is combined with Benzocaine.Approved
BepridilThe serum concentration of Colchicine can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Colchicine.Approved, Vet Approved
BevacizumabBevacizumab may increase the cardiotoxic activities of Colchicine.Approved, Investigational
BexaroteneThe serum concentration of Colchicine can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateBezafibrate may increase the myopathic rhabdomyolysis activities of Colchicine.Approved
BiperidenThe serum concentration of Colchicine can be increased when it is combined with Biperiden.Approved
BoceprevirThe serum concentration of Colchicine can be increased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Colchicine can be increased when it is combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Colchicine can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Colchicine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Colchicine.Approved
BromocriptineThe serum concentration of Colchicine can be increased when it is combined with Bromocriptine.Approved, Investigational
BuprenorphineThe serum concentration of Colchicine can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Colchicine can be increased when it is combined with Buspirone.Approved, Investigational
CabazitaxelThe serum concentration of Colchicine can be increased when it is combined with Cabazitaxel.Approved
CaffeineThe serum concentration of Colchicine can be increased when it is combined with Caffeine.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Colchicine.Experimental
CanagliflozinThe serum concentration of Colchicine can be increased when it is combined with Canagliflozin.Approved
CandesartanThe serum concentration of Colchicine can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Colchicine can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Colchicine can be increased when it is combined with Carbamazepine.Approved, Investigational
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Colchicine.Approved
CarvedilolThe serum concentration of Colchicine can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Colchicine can be increased when it is combined with Caspofungin.Approved
CeritinibThe serum concentration of Colchicine can be increased when it is combined with Ceritinib.Approved
CerivastatinColchicine may increase the myopathic rhabdomyolysis activities of Cerivastatin.Withdrawn
ChloroquineThe serum concentration of Colchicine can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorpromazineThe serum concentration of Colchicine can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Colchicine can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Colchicine can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
CholesterolThe serum concentration of Colchicine can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Colchicine can be decreased when it is combined with Cholic Acid.Approved
Choline C 11The therapeutic efficacy of Choline C 11 can be decreased when used in combination with Colchicine.Approved
CilazaprilThe serum concentration of Colchicine can be increased when it is combined with Cilazapril.Approved
CimetidineThe serum concentration of Colchicine can be increased when it is combined with Cimetidine.Approved
CiprofibrateCiprofibrate may increase the myopathic rhabdomyolysis activities of Colchicine.Approved
CiprofloxacinThe serum concentration of Colchicine can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Colchicine.Approved
CitalopramThe serum concentration of Colchicine can be increased when it is combined with Citalopram.Approved
ClarithromycinThe serum concentration of Colchicine can be increased when it is combined with Clarithromycin.Approved
ClemastineThe serum concentration of Colchicine can be increased when it is combined with Clemastine.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Colchicine.Approved, Illicit
ClofazimineThe serum concentration of Colchicine can be increased when it is combined with Clofazimine.Approved, Investigational
ClofibrateClofibrate may increase the myopathic rhabdomyolysis activities of Colchicine.Approved
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Colchicine.Approved, Investigational
ClomipramineThe serum concentration of Colchicine can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Colchicine.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Colchicine.Approved, Nutraceutical
ClotrimazoleThe serum concentration of Colchicine can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Colchicine.Approved
CobicistatThe serum concentration of Colchicine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Colchicine.Approved
Coenzyme Q10Colchicine may increase the myopathic rhabdomyolysis activities of Coenzyme Q10.Experimental
ColforsinThe serum concentration of Colchicine can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Colchicine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Colchicine.Approved
CrizotinibThe serum concentration of Colchicine can be increased when it is combined with Crizotinib.Approved
CyanocobalaminThe serum concentration of Cyanocobalamin can be decreased when it is combined with Colchicine.Approved, Nutraceutical
CyclophosphamideThe serum concentration of Colchicine can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Colchicine can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Colchicine.Approved
DabrafenibThe serum concentration of Colchicine can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Colchicine can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Colchicine can be increased when it is combined with Dactinomycin.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Colchicine.Approved
DarunavirThe serum concentration of Colchicine can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Colchicine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Colchicine can be increased when it is combined with Daunorubicin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Colchicine.Approved
DeferasiroxThe serum concentration of Colchicine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe serum concentration of Colchicine can be increased when it is combined with Delavirdine.Approved
DesipramineThe serum concentration of Colchicine can be increased when it is combined with Desipramine.Approved
DeslanosideDeslanoside may decrease the cardiotoxic activities of Colchicine.Approved
DesloratadineThe serum concentration of Colchicine can be increased when it is combined with Desloratadine.Approved, Investigational
DexamethasoneThe serum concentration of Colchicine can be increased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Colchicine can be increased when it is combined with Dextromethorphan.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Colchicine.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Colchicine can be increased when it is combined with Diclofenac.Approved, Vet Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Colchicine.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Colchicine.Approved
DigoxinThe serum concentration of Colchicine can be increased when it is combined with Digoxin.Approved
DihydroergotamineThe serum concentration of Colchicine can be increased when it is combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Colchicine.Illicit
DiltiazemThe serum concentration of Colchicine can be increased when it is combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Colchicine can be increased when it is combined with Dipyridamole.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Colchicine.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Colchicine.Approved, Investigational, Vet Approved
DoxazosinThe serum concentration of Colchicine can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Colchicine can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Colchicine.Approved, Investigational
DoxycyclineThe serum concentration of Colchicine can be increased when it is combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Colchicine can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe serum concentration of Colchicine can be increased when it is combined with Dronedarone.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Colchicine.Approved
EfavirenzThe serum concentration of Colchicine can be decreased when it is combined with Efavirenz.Approved, Investigational
ElbasvirThe serum concentration of Colchicine can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Colchicine.Approved, Investigational
EnalaprilThe serum concentration of Colchicine can be increased when it is combined with Enalapril.Approved, Vet Approved
EnzalutamideThe serum concentration of Colchicine can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Colchicine.Approved, Investigational
ErgonovineThe serum concentration of Colchicine can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Colchicine can be increased when it is combined with Ergotamine.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Colchicine.Approved, Investigational
ErythromycinThe serum concentration of Colchicine can be increased when it is combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of Colchicine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Colchicine.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Colchicine can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Colchicine can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Colchicine can be decreased when it is combined with Estrone.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Colchicine.Approved
EtofibrateEtofibrate may increase the myopathic rhabdomyolysis activities of Colchicine.Approved
EtoposideThe serum concentration of Colchicine can be increased when it is combined with Etoposide.Approved
EtravirineThe serum concentration of Colchicine can be increased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Colchicine.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Colchicine.Approved
FelodipineThe serum concentration of Colchicine can be increased when it is combined with Felodipine.Approved, Investigational
FenofibrateFenofibrate may increase the myopathic rhabdomyolysis activities of Colchicine.Approved
FentanylThe serum concentration of Colchicine can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Colchicine.Approved
FexofenadineThe serum concentration of Colchicine can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Colchicine can be increased when it is combined with Fidaxomicin.Approved
FluconazoleThe serum concentration of Colchicine can be increased when it is combined with Fluconazole.Approved
FluoxetineThe serum concentration of Colchicine can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Colchicine can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Colchicine can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Colchicine can be increased when it is combined with Flurazepam.Approved, Illicit
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Colchicine.Approved
FluvastatinColchicine may increase the myopathic rhabdomyolysis activities of Fluvastatin.Approved
FluvoxamineThe serum concentration of Colchicine can be increased when it is combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe serum concentration of Colchicine can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Colchicine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Colchicine can be increased when combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Colchicine can be increased when it is combined with Fusidic Acid.Approved
GefitinibThe serum concentration of Colchicine can be increased when it is combined with Gefitinib.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Colchicine.Approved
GemfibrozilGemfibrozil may increase the myopathic rhabdomyolysis activities of Colchicine.Approved
GenisteinThe serum concentration of Colchicine can be increased when it is combined with Genistein.Investigational
GlyburideThe serum concentration of Colchicine can be increased when it is combined with Glyburide.Approved
GlycerolThe serum concentration of Colchicine can be increased when it is combined with Glycerol.Experimental
Gramicidin DThe serum concentration of Colchicine can be increased when it is combined with Gramicidin D.Approved
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Colchicine.Approved
GrepafloxacinThe serum concentration of Colchicine can be increased when it is combined with Grepafloxacin.Withdrawn
HaloperidolThe serum concentration of Colchicine can be increased when it is combined with Haloperidol.Approved
HydrocortisoneThe serum concentration of Colchicine can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Colchicine.Approved
IdelalisibThe serum concentration of Colchicine can be increased when it is combined with Idelalisib.Approved
ImatinibThe serum concentration of Colchicine can be increased when it is combined with Imatinib.Approved
ImipramineThe serum concentration of Colchicine can be increased when it is combined with Imipramine.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Colchicine.Approved
IndinavirThe serum concentration of Colchicine can be increased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Colchicine can be increased when it is combined with Indomethacin.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Colchicine.Approved, Investigational
IsavuconazoniumThe serum concentration of Colchicine can be increased when it is combined with Isavuconazonium.Approved, Investigational
IsradipineThe serum concentration of Colchicine can be increased when it is combined with Isradipine.Approved
ItraconazoleThe serum concentration of Colchicine can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Colchicine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Colchicine can be increased when it is combined with Ivermectin.Approved, Vet Approved
KetamineThe serum concentration of Colchicine can be increased when it is combined with Ketamine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Colchicine.Approved
KetoconazoleThe serum concentration of Colchicine can be increased when it is combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Colchicine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Colchicine.Approved, Investigational
LansoprazoleThe serum concentration of Colchicine can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Colchicine can be increased when it is combined with Lapatinib.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Colchicine.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Colchicine.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Colchicine.Approved
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Colchicine.Approved, Investigational
LevofloxacinThe serum concentration of Colchicine can be increased when it is combined with Levofloxacin.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Colchicine.Approved
LevothyroxineThe serum concentration of Colchicine can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Colchicine can be increased when it is combined with Lidocaine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Colchicine.Approved
LiothyronineThe serum concentration of Colchicine can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Colchicine can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Colchicine can be increased when it is combined with Lisinopril.Approved, Investigational
LomitapideThe serum concentration of Colchicine can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Colchicine can be increased when it is combined with Loperamide.Approved
LopinavirThe serum concentration of Colchicine can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Colchicine can be increased when it is combined with Loratadine.Approved
LosartanThe serum concentration of Colchicine can be increased when it is combined with Losartan.Approved
LovastatinThe serum concentration of Colchicine can be increased when it is combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Colchicine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Colchicine can be decreased when it is combined with Lumacaftor.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Colchicine.Approved, Investigational
MaprotilineThe serum concentration of Colchicine can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Colchicine can be increased when it is combined with Mebendazole.Approved, Vet Approved
MefloquineThe serum concentration of Colchicine can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Colchicine can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MeprobamateThe serum concentration of Colchicine can be increased when it is combined with Meprobamate.Approved, Illicit
MethadoneThe serum concentration of Colchicine can be increased when it is combined with Methadone.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Colchicine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Colchicine.Approved, Vet Approved
MetoprololThe serum concentration of Colchicine can be increased when it is combined with Metoprolol.Approved, Investigational
MevastatinColchicine may increase the myopathic rhabdomyolysis activities of Mevastatin.Experimental
MibefradilThe serum concentration of Colchicine can be increased when it is combined with Mibefradil.Withdrawn
MiconazoleThe serum concentration of Colchicine can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Colchicine can be increased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Colchicine can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Colchicine.Approved
MitomycinThe serum concentration of Colchicine can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Colchicine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Colchicine can be increased when it is combined with Mitoxantrone.Approved, Investigational
ModafinilThe serum concentration of Colchicine can be decreased when it is combined with Modafinil.Approved, Investigational
MorphineThe serum concentration of Colchicine can be increased when it is combined with Morphine.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Colchicine.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Colchicine.Approved
NafcillinThe serum concentration of Colchicine can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Colchicine.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Colchicine.Approved, Vet Approved
NaltrexoneThe serum concentration of Colchicine can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Colchicine can be increased when it is combined with Naringenin.Experimental
NefazodoneThe serum concentration of Colchicine can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Colchicine can be increased when it is combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Colchicine can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Colchicine can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Colchicine can be increased when it is combined with Nevirapine.Approved
NicardipineThe serum concentration of Colchicine can be increased when it is combined with Nicardipine.Approved
NifedipineThe serum concentration of Colchicine can be increased when it is combined with Nifedipine.Approved
NilotinibThe serum concentration of Colchicine can be increased when it is combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Colchicine.Approved
NisoldipineThe serum concentration of Colchicine can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Colchicine can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Colchicine can be increased when it is combined with Nitrendipine.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Colchicine.Approved
NorethisteroneThe serum concentration of Colchicine can be decreased when it is combined with Norethisterone.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Colchicine.Approved, Investigational
OlaparibThe serum concentration of Colchicine can be increased when it is combined with Olaparib.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Colchicine.Approved
OmeprazoleThe serum concentration of Colchicine can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OsimertinibThe serum concentration of Colchicine can be increased when it is combined with Osimertinib.Approved
OuabainOuabain may decrease the cardiotoxic activities of Colchicine.Approved
P-NitrophenolThe serum concentration of Colchicine can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Colchicine can be increased when it is combined with Paclitaxel.Approved, Vet Approved
PalbociclibThe serum concentration of Colchicine can be increased when it is combined with Palbociclib.Approved
Palmitic AcidThe serum concentration of Colchicine can be increased when it is combined with Palmitic Acid.Experimental
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Colchicine.Approved, Investigational
PantoprazoleThe serum concentration of Colchicine can be increased when it is combined with Pantoprazole.Approved
ParoxetineThe serum concentration of Colchicine can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Colchicine.Approved
PentobarbitalThe metabolism of Colchicine can be increased when combined with Pentobarbital.Approved, Vet Approved
PerindoprilThe serum concentration of Colchicine can be increased when it is combined with Perindopril.Approved
PhenobarbitalThe metabolism of Colchicine can be increased when combined with Phenobarbital.Approved
PhenytoinThe metabolism of Colchicine can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe serum concentration of Colchicine can be increased when it is combined with Pimozide.Approved
PitavastatinColchicine may increase the myopathic rhabdomyolysis activities of Pitavastatin.Approved
Platelet Activating FactorThe serum concentration of Colchicine can be decreased when it is combined with Platelet Activating Factor.Experimental
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Colchicine.Approved
PonatinibThe serum concentration of Colchicine can be increased when it is combined with Ponatinib.Approved
PosaconazoleThe serum concentration of Colchicine can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PravastatinColchicine may increase the myopathic rhabdomyolysis activities of Pravastatin.Approved
PrazosinThe serum concentration of Colchicine can be increased when it is combined with Prazosin.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Colchicine.Approved, Vet Approved
PrednisoneThe serum concentration of Colchicine can be increased when it is combined with Prednisone.Approved, Vet Approved
PrimidoneThe metabolism of Colchicine can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Colchicine can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Colchicine can be increased when it is combined with Progesterone.Approved, Vet Approved
PromethazineThe serum concentration of Colchicine can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Colchicine can be increased when it is combined with Propafenone.Approved
PropranololThe serum concentration of Colchicine can be increased when it is combined with Propranolol.Approved, Investigational
ProtriptylineThe serum concentration of Colchicine can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Colchicine.Approved
QuercetinThe serum concentration of Colchicine can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Colchicine.Approved
QuinacrineThe serum concentration of Colchicine can be increased when it is combined with Quinacrine.Approved
QuinidineThe serum concentration of Colchicine can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Colchicine can be increased when it is combined with Quinine.Approved
RanitidineThe serum concentration of Colchicine can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Colchicine can be increased when it is combined with Ranolazine.Approved, Investigational
ReboxetineThe serum concentration of Colchicine can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Colchicine can be increased when it is combined with Regorafenib.Approved
ReserpineThe serum concentration of Colchicine can be increased when it is combined with Reserpine.Approved
RifabutinThe metabolism of Colchicine can be increased when combined with Rifabutin.Approved
RifampicinThe serum concentration of Colchicine can be increased when it is combined with Rifampicin.Approved
RifapentineThe metabolism of Colchicine can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Colchicine.Approved, Investigational
RilpivirineThe serum concentration of Colchicine can be increased when it is combined with Rilpivirine.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Colchicine.Approved, Investigational
RitonavirThe serum concentration of Colchicine can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Colchicine.Approved
RolapitantThe serum concentration of Colchicine can be increased when it is combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Colchicine.Approved, Investigational
RosuvastatinColchicine may increase the myopathic rhabdomyolysis activities of Rosuvastatin.Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Colchicine.Approved, Vet Approved
SaquinavirThe serum concentration of Colchicine can be increased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Colchicine.Approved
ScopolamineThe serum concentration of Colchicine can be increased when it is combined with Scopolamine.Approved
SelegilineThe serum concentration of Colchicine can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Colchicine.Approved
SertralineThe serum concentration of Colchicine can be increased when it is combined with Sertraline.Approved
SildenafilThe serum concentration of Colchicine can be increased when it is combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Colchicine.Approved
SiltuximabThe serum concentration of Colchicine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Colchicine can be increased when it is combined with Simeprevir.Approved
SimvastatinColchicine may increase the myopathic rhabdomyolysis activities of Simvastatin.Approved
SirolimusThe serum concentration of Colchicine can be increased when it is combined with Sirolimus.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Colchicine.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Colchicine.Approved
SorafenibThe serum concentration of Colchicine can be increased when it is combined with Sorafenib.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Colchicine.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Colchicine.Experimental
SpironolactoneThe serum concentration of Colchicine can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Colchicine can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Colchicine can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Colchicine can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Colchicine can be decreased when it is combined with Streptozocin.Approved
SulfinpyrazoneThe serum concentration of Colchicine can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleThe serum concentration of Colchicine can be increased when it is combined with Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Colchicine can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Colchicine can be increased when it is combined with Sunitinib.Approved, Investigational
TacrineThe serum concentration of Colchicine can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Colchicine can be increased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of Colchicine can be increased when it is combined with Tamoxifen.Approved
Taurocholic AcidThe serum concentration of Colchicine can be increased when it is combined with Taurocholic Acid.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Colchicine.Approved
TelaprevirThe serum concentration of Colchicine can be increased when it is combined with Telaprevir.Approved
TelithromycinThe serum concentration of Colchicine can be increased when it is combined with Telithromycin.Approved
TelmisartanThe serum concentration of Colchicine can be increased when it is combined with Telmisartan.Approved, Investigational
TemsirolimusThe serum concentration of Colchicine can be increased when it is combined with Temsirolimus.Approved
TerazosinThe serum concentration of Colchicine can be increased when it is combined with Terazosin.Approved
TerfenadineThe serum concentration of Colchicine can be increased when it is combined with Terfenadine.Withdrawn
TesmilifeneThe serum concentration of Colchicine can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Colchicine can be increased when it is combined with Testosterone.Approved, Investigational
TicagrelorThe serum concentration of Colchicine can be increased when it is combined with Ticagrelor.Approved
TiclopidineThe serum concentration of Colchicine can be increased when it is combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Colchicine.Approved
TipranavirThe serum concentration of Colchicine can be increased when it is combined with Tipranavir.Approved, Investigational
TocilizumabThe serum concentration of Colchicine can be decreased when it is combined with Tocilizumab.Approved
TolvaptanThe serum concentration of Colchicine can be increased when it is combined with Tolvaptan.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Colchicine.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Colchicine.Approved, Investigational
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Colchicine.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Colchicine.Approved
TrazodoneThe serum concentration of Colchicine can be decreased when it is combined with Trazodone.Approved, Investigational
TrifluoperazineThe serum concentration of Colchicine can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Colchicine can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Colchicine can be increased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Colchicine can be increased when it is combined with Trimipramine.Approved
TroleandomycinThe serum concentration of Colchicine can be increased when it is combined with Troleandomycin.Approved
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Colchicine.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Colchicine.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Colchicine.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Colchicine.Approved
VenlafaxineThe serum concentration of Colchicine can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Colchicine can be increased when it is combined with Verapamil.Approved
VinblastineThe serum concentration of Colchicine can be increased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Colchicine.Approved, Investigational
VinorelbineThe serum concentration of Colchicine can be increased when it is combined with Vinorelbine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Colchicine.Approved
VoriconazoleThe serum concentration of Colchicine can be increased when it is combined with Voriconazole.Approved, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Colchicine.Approved
ZimelidineThe serum concentration of Colchicine can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe serum concentration of Colchicine can be increased when it is combined with Ziprasidone.Approved
Food Interactions
  • Avoid alcohol since it increases uric acid levels.
  • Drink liberally.
  • Take without regard to meals.
References
Synthesis Reference

Christian Wehrey, “Colchicine derivatives, process for preparing them, products obtained therefrom and use thereof.” U.S. Patent US20040138182, issued July 15, 2004.

US20040138182
General ReferencesNot Available
External Links
ATC CodesM04AC01
AHFS Codes
  • 92:00.00
  • 92:02.00*
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74.9 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9856
Blood Brain Barrier+0.7865
Caco-2 permeable+0.5119
P-glycoprotein substrateNon-substrate0.594
P-glycoprotein inhibitor INon-inhibitor0.8007
P-glycoprotein inhibitor IINon-inhibitor0.6956
Renal organic cation transporterNon-inhibitor0.8997
CYP450 2C9 substrateNon-substrate0.8042
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7359
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.831
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7959
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9208
BiodegradationReady biodegradable0.6489
Rat acute toxicity2.3748 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9877
hERG inhibition (predictor II)Non-inhibitor0.7394
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
TabletOral.6 mg/1
TabletOral1 mg
TabletOral0.6 mg
Tablet, film coatedOral.6 mg/1
TabletOral1.0 mg
CapsuleOral.6 mg/1
TabletOral
OintmentTopical
Prices
Unit descriptionCostUnit
Colchicine powder306.6USD g
Colcrys 0.6 mg tablet5.82USD tablet
Colchicine 0.6 mg tablet0.58USD tablet
Colchicine 1 mg Tablet0.55USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7601758 No2009-02-102029-02-10Us
US7619004 No2008-12-032028-12-03Us
US7820681 No2009-02-172029-02-17Us
US7906519 No2009-02-172029-02-17Us
US7915269 No2009-02-172029-02-17Us
US7935731 No2008-12-032028-12-03Us
US7964647 No2008-10-062028-10-06Us
US7964648 No2008-10-062028-10-06Us
US7981938 No2008-10-062028-10-06Us
US8093296 No2008-10-062028-10-06Us
US8093297 No2008-10-062028-10-06Us
US8093298 No2008-10-062028-10-06Us
US8097655 No2008-10-062028-10-06Us
US8415395 No2008-10-062028-10-06Us
US8415396 No2008-10-062028-10-06Us
US8440721 No2009-02-172029-02-17Us
US8440722 No2009-02-172029-02-17Us
US8927607 No2013-08-222033-08-22Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point156 °CPhysProp
water solubility4.5E+004 mg/L (at 25 °C)SEIDELL,A (1941)
logP1.30HANSCH,C ET AL. (1995)
pKa1.85SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0276 mg/mLALOGPS
logP1.59ALOGPS
logP1.46ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)15.06ChemAxon
pKa (Strongest Basic)-0.038ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area83.09 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity111.38 m3·mol-1ChemAxon
Polarizability42.41 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (2.96 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tropones. These are compounds containing a tropone ring, which is a cycloheptatrienone ring bearing a ketone group.
KingdomOrganic compounds
Super ClassHydrocarbon derivatives
ClassTropones
Sub ClassNot Available
Direct ParentTropones
Alternative Parents
Substituents
  • Tropone
  • Anisole
  • Alkyl aryl ether
  • Benzenoid
  • Acetamide
  • Cyclic ketone
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Ether
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Structural constituent of cytoskeleton
Specific Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Gene Name:
TUBB1
Uniprot ID:
Q9H4B7
Molecular Weight:
50326.56 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Acharya BR, Choudhury D, Das A, Chakrabarti G: Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry. 2009 Jul 28;48(29):6963-74. doi: 10.1021/bi900152k. [PubMed:19527023 ]
  4. Li CM, Lu Y, Ahn S, Narayanan R, Miller DD, Dalton JT: Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin. J Mass Spectrom. 2010 Oct;45(10):1160-6. doi: 10.1002/jms.1804. [PubMed:20814887 ]
  5. Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y: Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila). 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. [PubMed:20586571 ]
  6. Cerquaglia C, Diaco M, Nucera G, La Regina M, Montalto M, Manna R: Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update. Curr Drug Targets Inflamm Allergy. 2005 Feb;4(1):117-24. [PubMed:15720245 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Ubiquitin protein ligase binding
Specific Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Name:
TUBB
Uniprot ID:
P07437
Molecular Weight:
49670.515 Da
References
  1. Yee KW, Hagey A, Verstovsek S, Cortes J, Garcia-Manero G, O'Brien SM, Faderl S, Thomas D, Wierda W, Kornblau S, Ferrajoli A, Albitar M, McKeegan E, Grimm DR, Mueller T, Holley-Shanks RR, Sahelijo L, Gordon GB, Kantarjian HM, Giles FJ: Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies. Clin Cancer Res. 2005 Sep 15;11(18):6615-24. [PubMed:16166440 ]
  2. Acharya BR, Choudhury D, Das A, Chakrabarti G: Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry. 2009 Jul 28;48(29):6963-74. doi: 10.1021/bi900152k. [PubMed:19527023 ]
  3. Li CM, Lu Y, Ahn S, Narayanan R, Miller DD, Dalton JT: Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin. J Mass Spectrom. 2010 Oct;45(10):1160-6. doi: 10.1002/jms.1804. [PubMed:20814887 ]
  4. Cerquaglia C, Diaco M, Nucera G, La Regina M, Montalto M, Manna R: Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update. Curr Drug Targets Inflamm Allergy. 2005 Feb;4(1):117-24. [PubMed:15720245 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi ...
Gene Name:
ABCB4
Uniprot ID:
P21439
Molecular Weight:
141521.845 Da
References
  1. Vollrath V, Wielandt AM, Acuna C, Duarte I, Andrade L, Chianale J: Effect of colchicine and heat shock on multidrug resistance gene and P-glycoprotein expression in rat liver. J Hepatol. 1994 Nov;21(5):754-63. [PubMed:7890890 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Toxin transporter activity
Specific Function:
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
Gene Name:
SLC22A3
Uniprot ID:
O75751
Molecular Weight:
61279.485 Da
References
  1. Grundemann D, Schechinger B, Rappold GA, Schomig E: Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci. 1998 Sep;1(5):349-51. [PubMed:10196521 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674 ]
  2. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  3. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
  4. Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. [PubMed:12948019 ]
  5. Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I: Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8472-6. [PubMed:1356264 ]
  6. Bebawy M, Morris MB, Roufogalis BD: A continuous fluorescence assay for the study of P-glycoprotein-mediated drug efflux using inside-out membrane vesicles. Anal Biochem. 1999 Mar 15;268(2):270-7. [PubMed:10075817 ]
  7. Kuo CC, Hsieh HP, Pan WY, Chen CP, Liou JP, Lee SJ, Chang YL, Chen LT, Chen CT, Chang JY: BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer Res. 2004 Jul 1;64(13):4621-8. [PubMed:15231674 ]
  8. Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. doi: 10.1016/j.bcp.2009.04.002. Epub 2009 Apr 11. [PubMed:19427995 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Stride BD, Grant CE, Loe DW, Hipfner DR, Cole SP, Deeley RG: Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997 Sep;52(3):344-53. [PubMed:9281595 ]
Comments
comments powered by Disqus
Drug created on July 08, 2007 11:02 / Updated on December 09, 2016 02:40