Kaolin

Identification

Name
Kaolin
Accession Number
DB01575
Type
Small Molecule
Groups
Approved
Description

Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate.

Structure
Thumb
Synonyms
  • Kaolin, light
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dr Pore Tightening GLACIAL CLAY FACIAL MASKCream8 g/100mLTopicalLab & Company Inc.2017-11-01Not applicableUs
Dr Pore Tightening PINK CLAY FACIAL MASKCream4 g/100gTopicalLab & Company Inc.2017-11-01Not applicableUs
Look At Me Mud Face Mask Mini Pack PomegranatePaste4.5 g/30mLTopicalYoungwon Costech Co., Ltd.2018-03-30Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Body ScrubKaolin (6 g/375g) + Glycerin (7.5 g/375g)GelTopicalMilk & Co Pty Ltd2014-01-08Not applicableUs
Diaret LiqKaolin (3.078 g) + Pectin (150 mg)LiquidOralProduits Francais Labs Inc.1981-12-311997-05-30Canada
DiarexKaolin (6.156 g) + Pectin (300 mg)LiquidOralPharmavite Laboratories (1987) Inc.1977-12-311999-10-19Canada
Donnagel LiqKaolin (6 g) + Atropine Sulfate (0.0194 mg) + Hyoscyamine sulfate (0.1037 mg) + Pectin (142.8 mg) + Scopolamine (6.5 mcg)LiquidOralAyerst Laboratories1993-12-311996-09-10Canada
Donnagel LiqKaolin (6 g) + Atropine Sulfate (0.0194 mg) + Hyoscyamine sulfate (0.1037 mg) + Pectin (142.8 mg) + Scopolamine (6.5 mcg)LiquidOralWyeth Ayerst Canada Inc.1995-12-311997-08-14Canada
Donnagel-MB SusKaolin (6 g) + Pectin (142.8 mg)SuspensionOralAyerst Laboratories1991-12-311996-09-10Canada
Donnagel-PG LiqKaolin (6 g) + Opium (24 mg) + Pectin (142.8 mg)LiquidOralWyeth Ayerst Canada Inc.1994-12-312001-04-23Canada
Gold Bond Baby Cornstarch PlusKaolin (.04 g/g) + Starch, corn (.79 g/g) + Zinc oxide (.15 g/g)PowderTopicalChattem, Inc.1996-04-29Not applicableUs
Kaolin and Pectin SuspKaolin (200 mg) + Pectin (10 mg)SuspensionOralDrug Trading Company Ltd.1963-12-311997-08-12Canada
Kaolin Mixture W Pectin NfKaolin (200 mg) + Pectin (10 mg)LiquidOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1972-12-312000-07-27Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Mefactory Pig Collagen 1step Piggy Nose PackKaolin (.002 g/.2g)PatchTopicalMe Factory Co., Ltd.2016-12-01Not applicableUs
Sonatural Facial Design Deep Black Clay MaskKaolin (3.5 g/14g)PatchTopicalSonatural Global Co.,ltd2017-10-01Not applicableUs
Sonatural Facial Design Pink Mud MaskKaolin (2.8 g/14g)PatchTopicalSonatural Global Co.,ltd2017-03-02Not applicableUs
Sonatural The Pure Pore Tensing Carbonic Bubble Pop Clay MaskKaolin (45.5 g/130g)CreamTopicalSonatural Global Co.,ltd2017-10-01Not applicableUs
W Lab ALL CLEAR MINT PACKKaolin (15 g/100mL)CreamTopicalWow Ventures2016-10-102017-08-30Us
Categories
UNII
24H4NWX5CO
CAS number
1332-58-7
Weight
Average: 258.156
Monoisotopic: 257.9024618
Chemical Formula
Al2H4O9Si2
InChI Key
KGOIAFZMMLWXLM-UHFFFAOYSA-N
InChI
InChI=1S/2Al.O7Si2.2H2O/c;;1-8(2,3)7-9(4,5)6;;/h;;;2*1H2/q2*+3;-6;;
IUPAC Name
dialuminium(3+) ion [(trioxidosilyl)oxy]silanetris(olate) dihydrate
SMILES
O.O.[Al+3].[Al+3].[O-][Si]([O-])([O-])O[Si]([O-])([O-])[O-]

Pharmacology

Indication

Used for upset stomach and diarrhea, a traditional medicine used in China, South America and Africa. Kaolin is also used to treat AIDs-related diarrhea. Kaolin based bandages are also under investigation.

Associated Conditions
Pharmacodynamics

Kaolin is an adsorptive agent.

Mechanism of action

Kaolin adsorbs water, toxins and bacteria, contributing to firmer stools, reducing fluid loss from diarrhea.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AcetyldigitoxinThe serum concentration of Acetyldigitoxin can be decreased when it is combined with Kaolin.Approved
AcetyldigoxinThe serum concentration of Acetyldigoxin can be decreased when it is combined with Kaolin.Experimental
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Kaolin.Approved, Investigational, Vet Approved
ClindamycinKaolin can cause a decrease in the absorption of Clindamycin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Vet Approved
CymarinThe serum concentration of Cymarin can be decreased when it is combined with Kaolin.Experimental
DeslanosideThe serum concentration of Deslanoside can be decreased when it is combined with Kaolin.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Kaolin.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Kaolin.Approved
Digoxin Immune Fab (Ovine)The serum concentration of Digoxin Immune Fab (Ovine) can be decreased when it is combined with Kaolin.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Kaolin.Approved
GitoformateThe serum concentration of Gitoformate can be decreased when it is combined with Kaolin.Experimental
Lanatoside CThe serum concentration of Lanatoside C can be decreased when it is combined with Kaolin.Experimental
LincomycinKaolin can cause a decrease in the absorption of Lincomycin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Vet Approved
MetildigoxinThe serum concentration of Metildigoxin can be decreased when it is combined with Kaolin.Experimental
OleandrinThe serum concentration of Oleandrin can be decreased when it is combined with Kaolin.Experimental, Investigational
OuabainThe serum concentration of Ouabain can be decreased when it is combined with Kaolin.Approved
PeruvosideThe serum concentration of Peruvoside can be decreased when it is combined with Kaolin.Experimental
PirlimycinKaolin can cause a decrease in the absorption of Pirlimycin resulting in a reduced serum concentration and potentially a decrease in efficacy.Vet Approved
ProscillaridinThe serum concentration of Proscillaridin can be decreased when it is combined with Kaolin.Experimental
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Kaolin.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Joseph C. Muhler, Mark S. Putt, "Dentifrice preparation comprising purified, calcined kaolin abrasives." U.S. Patent US4122163, issued April, 1948.

US4122163
General References
  1. Trabattoni D, Gatto P, Bartorelli AL: A new kaolin-based hemostatic bandage use after coronary diagnostic and interventional procedures. Int J Cardiol. 2012 Apr 5;156(1):53-4. doi: 10.1016/j.ijcard.2010.10.030. Epub 2010 Nov 18. [PubMed:21087799]
External Links
PubChem Compound
92024769
PubChem Substance
46508763
ChemSpider
21241417
PharmGKB
PA10457
Drugs.com
Drugs.com Drug Page
Wikipedia
Kaolin
ATC Codes
A07BC02 — Kaolin
MSDS
Download (74.1 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Chattem Chemicals Inc.
  • Mallinckrodt Inc.
  • Pharmacia Inc.
Dosage forms
FormRouteStrength
GelTopical
SuspensionOral
CreamTopical8 g/100mL
CreamTopical4 g/100g
PowderTopical
LiquidOral
OintmentTopical
PasteTopical4.5 g/30mL
PatchTopical.002 g/.2g
CreamTopical
PatchTopical3.5 g/14g
PatchTopical2.8 g/14g
CreamTopical45.5 g/130g
CreamTopical15 g/100mL
Prices
Unit descriptionCostUnit
Kaopectate 262 mg caplet0.37USD each
Kaopectate 240 mg softgel0.25USD each
Kaolin powder0.03USD g
Kaopectate children's susp0.02USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-3.9ChemAxon
pKa (Strongest Acidic)8.24ChemAxon
pKa (Strongest Basic)-4.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area147.59 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity10.01 m3·mol-1ChemAxon
Polarizability9.46 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as post-transition metal silicates. These are inorganic compounds in which the largest oxoanion is silicate, and in which the heaviest atom not in an oxoanion is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal oxoanionic compounds
Sub Class
Post-transition metal silicates
Direct Parent
Post-transition metal silicates
Alternative Parents
Miscellaneous silicates / Post-transition metal salts / Metalloid salts / Inorganic salts / Inorganic oxides
Substituents
Post-transition metal silicate / Silicate / Inorganic post-transition metal salt / Inorganic oxide / Inorganic salt / Inorganic metalloid salt
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on August 29, 2007 08:49 / Updated on August 02, 2018 04:38