Also known as: Dysmenorrhea / Dysmenorrheas / Menorrhalgia / Menstrual cramps / Cramps menstrual / Menstrual cramp / Dysmenorrhoea / Dysmenorrhea, unspecified / Period pains / Menses painful / Pain menstrual / Painful periods
DrugDrug NameDrug Description
DB01395DrospirenoneDrospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats.
DB00977Ethinyl EstradiolA semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally and is often used as the estrogenic component in oral contraceptives. Ethinyl estradiol is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Tri-Cyclen, Triphasil, and Yasmin. The FDA label includes a black box warning that states that combination oral contraceptives should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.
DB00823Ethynodiol diacetateA synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive. Although etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug that has never been marketed, see [DB13866]).
DB00712FlurbiprofenFlurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
DB01357MestranolThe 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
DB00788NaproxenAn anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
DB00957NorgestimateNorgestimate is a form of progesterone, which is a female hormone important for the regulation of ovulation and menstruation. Norgestimate is used with estradiol to treat the symptoms of menopause.
DB09389NorgestrelNorgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer (levonorgestrel) is biologically active.
DrugDrug NameTargetType
DB01395DrospirenoneProgesterone receptortarget
DB01395DrospirenoneMineralocorticoid receptortarget
DB01395DrospirenoneAndrogen receptortarget
DB01395DrospirenoneProstaglandin G/H synthase 2enzyme
DB01395DrospirenoneCholinesteraseenzyme
DB01395DrospirenoneCytochrome P450 3A4enzyme
DB00977Ethinyl EstradiolEstrogen receptor alphatarget
DB00977Ethinyl EstradiolNuclear receptor subfamily 1 group I member 2target
DB00977Ethinyl EstradiolCytochrome P450 3A4enzyme
DB00977Ethinyl EstradiolCytochrome P450 2C8enzyme
DB00977Ethinyl EstradiolBile salt export pumptransporter
DB00977Ethinyl EstradiolSodium/bile acid cotransportertransporter
DB00977Ethinyl EstradiolCanalicular multispecific organic anion transporter 1transporter
DB00977Ethinyl EstradiolMultidrug resistance protein 1transporter
DB00977Ethinyl EstradiolSex hormone-binding globulintarget
DB00823Ethynodiol diacetateEstrogen receptor alphatarget
DB00823Ethynodiol diacetateProgesterone receptortarget
DB00712FlurbiprofenProstaglandin G/H synthase 2target
DB00712FlurbiprofenProstaglandin G/H synthase 1target
DB00712FlurbiprofenCytochrome P450 2C9enzyme
DB00712FlurbiprofenSerum albumincarrier
DB00712FlurbiprofenMultidrug resistance-associated protein 4transporter
DB00712FlurbiprofenSolute carrier family 22 member 6transporter
DB00712FlurbiprofenUDP-glucuronosyltransferase 2B7enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 1-1enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 1-3enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 1-9enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 2B4enzyme
DB01357MestranolEstrogen receptor alphatarget
DB01357MestranolCytochrome P450 2C9enzyme
DB01357MestranolCytochrome P450 1A2enzyme
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenSerum albumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-1enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00957NorgestimateProgesterone receptortarget
DB00957NorgestimateEstrogen receptor alphatarget
DB00957NorgestimateCanalicular multispecific organic anion transporter 1transporter
DB00957NorgestimateCytochrome P450 3A4enzyme
DB00957NorgestimateAndrogen receptortarget
DB09389NorgestrelProgesterone receptortarget
DB09389Norgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1target
DB09389NorgestrelAndrogen receptortarget
DB09389NorgestrelCytochrome P450 3A4enzyme
DB09389NorgestrelCytochrome P450 19A1enzyme
DrugDrug NamePhaseStatusCount
DB00203Sildenafil1 / 2Completed1
DB01164Calcium Chloride2Completed1
DB00668Epinephrine2Completed2
DB00977Ethinyl Estradiol2Completed1
DB01050Ibuprofen2Completed1
DB00367Levonorgestrel2Completed1
DB00281Lidocaine2Completed2
DB00784Mefenamic acid2Completed1
DB00814Meloxicam2Completed1
DB00761Potassium Chloride2Completed1
DB09153Sodium Chloride2Completed1
DB00586Diclofenac2 / 3Recruiting1
DB00814Meloxicam2 / 3Recruiting1
DB00201Caffeine3Completed1
DB01395Drospirenone3Completed1
DB01395Drospirenone3Withdrawn1
DB00977Ethinyl Estradiol3Completed1
DB01628Etoricoxib3Completed2
DB01050Ibuprofen3Completed1
DB01050Ibuprofen3Terminated1
DB00007Leuprolide3Unknown Status1
DB00367Levonorgestrel3Completed1
DB00788Naproxen3Completed1
DB00717Norethisterone3Unknown Status1
DB00316Acetaminophen4Unknown Status1
DB09214Dexketoprofen4Unknown Status1
DB01395Drospirenone4Unknown Status1
DB06751Drotaverine4Terminated1
DB00977Ethinyl Estradiol4Recruiting1
DB00977Ethinyl Estradiol4Unknown Status1
DB00717Norethisterone4Recruiting1
DB00554Piroxicam4Completed1
DB00580Valdecoxib4Completed1
DB00316AcetaminophenNot AvailableCompleted1
DB01395DrospirenoneNot AvailableActive Not Recruiting1
DB00977Ethinyl EstradiolNot AvailableActive Not Recruiting1
DB00977Ethinyl EstradiolNot AvailableWithdrawn1
DB01050IbuprofenNot AvailableCompleted1
DB06713NorelgestrominNot AvailableWithdrawn1