Identification

Name
Dexketoprofen
Accession Number
DB09214
Type
Small Molecule
Groups
Approved, Investigational
Description

Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties [2].

Structure
Thumb
Synonyms
Not Available
International/Other Brands
ACTIDEX / DESKETO / DEXADOL / DEXAK / DEXALGIN / DEXAROM / DEXOFEN / DEXOKET / DEXOMEN / DEXPRO / DEXTANOL / DEXTRAFAST / DKTROM / ELEKTRA / ENANGEL / ENANTYUM / FEN LI / INFEN / KERAL / KETRON D / KITESSE / KITEX / QUIRALAM / QUIRGEL / ROTALFEN / ROTALGIN / STADIUM / SYMPAL / TOFEDEX / VIAXAL / YOUBAIFEN
Categories
UNII
6KD9E78X68
CAS number
22161-81-5
Weight
Average: 254.2806
Monoisotopic: 254.094294314
Chemical Formula
C16H14O3
InChI Key
DKYWVDODHFEZIM-NSHDSACASA-N
InChI
InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m0/s1
IUPAC Name
(2S)-2-(3-benzoylphenyl)propanoic acid
SMILES
[H][C@@](C)(C(O)=O)C1=CC(=CC=C1)C(=O)C1=CC=CC=C1

Pharmacology

Indication

For short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache [6].

Pharmacodynamics

This drug is an isomer of ketoprofen. Dexketoprofen a propionic acid derivative with analgesic, anti-inflammatory, and antipyretic properties [3].

Mechanism of action

It is a non-steroidal anti-inflammatory drug (NSAID) that reduces prostaglandin synthesis via inhibition of cyclooxygenase pathway (both COX-1 and COX-2) activity [3].

TargetActionsOrganism
UProstaglandin G/H synthase 1
antagonist
Human
UProstaglandin G/H synthase 2
antagonist
Human
Absorption

After oral ingestion, the Dexketoprofen onset of action is within 30 minutes. The plasma half-life of Dexketoprofen is about 4-6 hours. The Cmax is about 30 minutes [L1204]

Volume of distribution

<0.25 L/kg [3]

Protein binding

Highly protein bound [3].

Metabolism

Dexketoprofen is highly lipophilic, and is metabolized in the liver by glucuronidation [7]. In one study, after oral administration of 25 mg of dexketoprofen to young healthy adults, Tmax was approximately 30 min for a Cmax of 3.7 ± 0.72 mg/l [8]. Dexketoprofen trometamol is metabolized by the hepatic cytochrome P450 enzymes (CYP2C8 and CYP2C9) [8].

Dexketoprofen trometamol has a number of metabolites, with hydroxyl derivatives making up the greatest volume [8]. In humans, hydroxylation plays a minor role.

Dexketoprofen is primarily conjugated to an acyl-glucuronide [8]

Route of elimination

Approximately 70 to 80% of the ingested dose is recovered in the urine during the first 12 hours post-ingestion, mainly as the acyl-conjugated form of the drug [5].

Half life

1.65 h [3]

Clearance

Mainly cleared via glucuronide conjugation and followed by renal excretion, mainly unchanged [3].

Toxicity

Nausea and/or vomiting, stomach pain, diarrhea, digestive problems (dyspepsia) are the most common symptoms of toxicity. More toxicity symptoms include dizziness, sleepiness, disturbed sleep, nervousness, headache, palpitations, flushing, stomach problems, constipation, dry mouth, flatulence, skin rash, tiredness, pain, feeling feverish and shivering, and malaise.

Severe toxicity can lead to thrombocytopenia and anemia with bleeding episodes. Dexketoprofen is associated with a small increased risk of myocardial infarction [6].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limoneneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with (4R)-limonene.Investigational
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when 16-Bromoepiandrosterone is combined with Dexketoprofen.Investigational
19-norandrostenedioneThe risk or severity of adverse effects can be increased when 19-norandrostenedione is combined with Dexketoprofen.Experimental, Illicit
5-(2-methylpiperazine-1-sulfonyl)isoquinolineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with 5-(2-methylpiperazine-1-sulfonyl)isoquinoline.Experimental
5-androstenedioneThe risk or severity of adverse effects can be increased when 5-androstenedione is combined with Dexketoprofen.Experimental, Illicit
AceclofenacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Aceclofenac.Approved, Investigational
AcemetacinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolDexketoprofen may increase the anticoagulant activities of Acenocoumarol.Approved, Investigational
Acetyl sulfisoxazoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Acetyl sulfisoxazole.Approved, Vet Approved
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Dexketoprofen.Approved, Vet Approved
AdapaleneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Adapalene.Approved
AlaproclateAlaproclate may increase the antiplatelet activities of Dexketoprofen.Experimental
AlclofenacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Alclofenac.Approved, Withdrawn
AlclometasoneThe risk or severity of adverse effects can be increased when Alclometasone is combined with Dexketoprofen.Approved
AldosteroneThe risk or severity of adverse effects can be increased when Aldosterone is combined with Dexketoprofen.Experimental, Investigational
AlminoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Alminoprofen.Experimental
AloxiprinThe risk or severity of adverse effects can be increased when Aloxiprin is combined with Dexketoprofen.Experimental
AmcinonideThe risk or severity of adverse effects can be increased when Amcinonide is combined with Dexketoprofen.Approved
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Aminosalicylic Acid is combined with Dexketoprofen.Approved
AndrographolideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Andrographolide.Investigational
AndrostenedioneThe risk or severity of adverse effects can be increased when Androstenedione is combined with Dexketoprofen.Experimental, Illicit
AnecortaveThe risk or severity of adverse effects can be increased when Anecortave is combined with Dexketoprofen.Investigational
anecortave acetateThe risk or severity of adverse effects can be increased when anecortave acetate is combined with Dexketoprofen.Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Anisodamine.Investigational
AntipyrineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Antipyrine.Approved, Investigational
ApocyninThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Apocynin.Investigational
ApremilastThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Apremilast.Approved, Investigational
AtamestaneThe risk or severity of adverse effects can be increased when Atamestane is combined with Dexketoprofen.Investigational
AzapropazoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Azapropazone.Withdrawn
AzelastineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Azelastine.Approved
AzosemideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Azosemide.Investigational
BalsalazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Balsalazide.Approved, Investigational
BazedoxifeneDexketoprofen may increase the thrombogenic activities of Bazedoxifene.Approved, Investigational
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Beclomethasone dipropionate is combined with Dexketoprofen.Approved, Investigational
BendazacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Bendazac.Experimental
BendroflumethiazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Bendroflumethiazide.Approved
BenorilateThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Benorilate.Experimental
BenoxaprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Benoxaprofen.Withdrawn
BenzthiazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Benzthiazide.Approved
BenzydamineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Benzydamine.Approved
BetamethasoneThe risk or severity of adverse effects can be increased when Betamethasone is combined with Dexketoprofen.Approved, Vet Approved
BevoniumThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Bevonium.Experimental
BromfenacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Bromfenac.Approved
BucillamineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Bucillamine.Investigational
BudesonideThe risk or severity of adverse effects can be increased when Budesonide is combined with Dexketoprofen.Approved
BufexamacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Bufexamac.Approved, Experimental
BumadizoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Bumadizone.Experimental
BumetanideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Bumetanide.Approved
Carbaspirin calciumThe risk or severity of adverse effects can be increased when Carbaspirin calcium is combined with Dexketoprofen.Experimental, Investigational
CarprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Carprofen.Approved, Vet Approved, Withdrawn
CastanospermineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Castanospermine.Experimental
CelecoxibThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Celecoxib.Approved, Investigational
Chloramine-TThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Chloramine-T.Vet Approved
ChloroquineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Chloroquine.Approved, Investigational, Vet Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Chlorothiazide.Approved, Vet Approved
ChlorotrianiseneDexketoprofen may increase the thrombogenic activities of Chlorotrianisene.Investigational, Withdrawn
ChlorsulfaquinoxalineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Chlorsulfaquinoxaline.Investigational
ChlorthalidoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Chlorthalidone.Approved
Choline magnesium trisalicylateThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Choline magnesium trisalicylate.Approved
CiclesonideThe risk or severity of adverse effects can be increased when Ciclesonide is combined with Dexketoprofen.Approved, Investigational
CitalopramCitalopram may increase the antiplatelet activities of Dexketoprofen.Approved
ClobetasolThe risk or severity of adverse effects can be increased when Clobetasol is combined with Dexketoprofen.Approved, Investigational
Clobetasol propionateThe risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Dexketoprofen.Approved
ClobetasoneThe risk or severity of adverse effects can be increased when Clobetasone is combined with Dexketoprofen.Approved
ClocortoloneThe risk or severity of adverse effects can be increased when Clocortolone is combined with Dexketoprofen.Approved
ClonixinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Clonixin.Approved
ClopamideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Clopamide.Experimental
ClorindioneDexketoprofen may increase the anticoagulant activities of Clorindione.Experimental
ClorsulonThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Clorsulon.Vet Approved
Conjugated estrogensDexketoprofen may increase the thrombogenic activities of Conjugated estrogens.Approved
Cortexolone 17α-propionateThe risk or severity of adverse effects can be increased when Cortexolone 17α-propionate is combined with Dexketoprofen.Investigational
CorticosteroneThe risk or severity of adverse effects can be increased when Corticosterone is combined with Dexketoprofen.Experimental
Cortisone acetateThe risk or severity of adverse effects can be increased when Cortisone acetate is combined with Dexketoprofen.Approved, Investigational
CurcuminThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Curcumin.Approved, Investigational
CyclopenthiazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Cyclopenthiazide.Experimental
CyclothiazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Cyclothiazide.Approved
DaidzeinDexketoprofen may increase the thrombogenic activities of Daidzein.Experimental
DantroleneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Dantrolene.Approved, Investigational
DapoxetineDapoxetine may increase the antiplatelet activities of Dexketoprofen.Investigational
DarunavirThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Darunavir.Approved
DeflazacortThe risk or severity of adverse effects can be increased when Deflazacort is combined with Dexketoprofen.Approved, Investigational
DersalazineThe risk or severity of adverse effects can be increased when Dersalazine is combined with Dexketoprofen.Investigational
DesonideThe risk or severity of adverse effects can be increased when Desonide is combined with Dexketoprofen.Approved, Investigational
DesoximetasoneThe risk or severity of adverse effects can be increased when Desoximetasone is combined with Dexketoprofen.Approved
Desoxycorticosterone acetateThe risk or severity of adverse effects can be increased when Desoxycorticosterone acetate is combined with Dexketoprofen.Approved
Desoxycorticosterone PivalateThe risk or severity of adverse effects can be increased when Desoxycorticosterone Pivalate is combined with Dexketoprofen.Experimental, Vet Approved
DesvenlafaxineDesvenlafaxine may increase the antiplatelet activities of Dexketoprofen.Approved, Investigational
DexamethasoneThe risk or severity of adverse effects can be increased when Dexamethasone is combined with Dexketoprofen.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe risk or severity of adverse effects can be increased when Dexamethasone isonicotinate is combined with Dexketoprofen.Vet Approved
DiazoxideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Diazoxide.Approved
DiclofenacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Diclofenac.Approved, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Diclofenamide.Approved, Investigational
DicoumarolDexketoprofen may increase the anticoagulant activities of Dicoumarol.Approved
DienestrolDexketoprofen may increase the thrombogenic activities of Dienestrol.Approved, Investigational
DiethylstilbestrolDexketoprofen may increase the thrombogenic activities of Diethylstilbestrol.Approved, Investigational
DifenpiramideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Difenpiramide.Experimental
DiflorasoneThe risk or severity of adverse effects can be increased when Diflorasone is combined with Dexketoprofen.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Diflunisal is combined with Dexketoprofen.Approved, Investigational
DifluocortoloneThe risk or severity of adverse effects can be increased when Difluocortolone is combined with Dexketoprofen.Approved, Investigational, Withdrawn
DifluprednateThe risk or severity of adverse effects can be increased when Difluprednate is combined with Dexketoprofen.Approved
DiphenadioneDexketoprofen may increase the anticoagulant activities of Diphenadione.Experimental
DroxicamThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Droxicam.Withdrawn
DuloxetineDuloxetine may increase the antiplatelet activities of Dexketoprofen.Approved
DuvelisibThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Duvelisib.Investigational
E-6201The risk or severity of adverse effects can be increased when Dexketoprofen is combined with E-6201.Investigational
EpimestrolDexketoprofen may increase the thrombogenic activities of Epimestrol.Experimental
EpirizoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Epirizole.Approved
EquileninThe risk or severity of adverse effects can be increased when Equilenin is combined with Dexketoprofen.Experimental
EquilinThe risk or severity of adverse effects can be increased when Equilin is combined with Dexketoprofen.Approved
EquolDexketoprofen may increase the thrombogenic activities of Equol.Investigational
EscitalopramEscitalopram may increase the antiplatelet activities of Dexketoprofen.Approved, Investigational
EstradiolDexketoprofen may increase the thrombogenic activities of Estradiol.Approved, Investigational, Vet Approved
Estradiol acetateDexketoprofen may increase the thrombogenic activities of Estradiol acetate.Approved, Investigational, Vet Approved
Estradiol cypionateDexketoprofen may increase the thrombogenic activities of Estradiol cypionate.Approved, Investigational, Vet Approved
Estradiol valerateDexketoprofen may increase the thrombogenic activities of Estradiol valerate.Approved, Investigational, Vet Approved
EstriolDexketoprofen may increase the thrombogenic activities of Estriol.Approved, Investigational, Vet Approved
Estrogens, esterifiedDexketoprofen may increase the thrombogenic activities of Estrogens, esterified.Approved
EstroneDexketoprofen may increase the thrombogenic activities of Estrone.Approved
Estrone sulfateThe risk or severity of adverse effects can be increased when Estrone sulfate is combined with Dexketoprofen.Approved
EtanerceptThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Etanercept.Approved, Investigational
EthenzamideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Ethenzamide.Experimental
Ethinyl EstradiolDexketoprofen may increase the thrombogenic activities of Ethinyl Estradiol.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Ethoxzolamide.Withdrawn
Ethyl biscoumacetateDexketoprofen may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtodolacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Etofenamate.Approved, Investigational
EtoperidoneEtoperidone may increase the antiplatelet activities of Dexketoprofen.Withdrawn
EtoricoxibThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Etoricoxib.Approved, Investigational
Evening primrose oilThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Evening primrose oil.Investigational, Nutraceutical
ExisulindThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Exisulind.Investigational
FelbinacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Felbinac.Experimental
FenbufenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Fenbufen.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Fenoprofen.Approved
FentiazacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Fentiazac.Experimental
FeprazoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Feprazone.Experimental
Ferulic acidThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Ferulic acid.Experimental
FloctafenineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Floctafenine.Approved, Withdrawn
FluasteroneThe risk or severity of adverse effects can be increased when Fluasterone is combined with Dexketoprofen.Investigational
FludrocortisoneThe risk or severity of adverse effects can be increased when Fludrocortisone is combined with Dexketoprofen.Approved, Investigational
FluindioneDexketoprofen may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlumethasoneThe risk or severity of adverse effects can be increased when Flumethasone is combined with Dexketoprofen.Approved, Vet Approved
FlunisolideThe risk or severity of adverse effects can be increased when Flunisolide is combined with Dexketoprofen.Approved, Investigational
FlunixinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Flunixin.Vet Approved
FlunoxaprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Flunoxaprofen.Experimental
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Fluocinolone Acetonide is combined with Dexketoprofen.Approved, Investigational, Vet Approved
FluocinonideThe risk or severity of adverse effects can be increased when Fluocinonide is combined with Dexketoprofen.Approved, Investigational
FluocortoloneThe risk or severity of adverse effects can be increased when Fluocortolone is combined with Dexketoprofen.Approved, Withdrawn
FluorometholoneThe risk or severity of adverse effects can be increased when Fluorometholone is combined with Dexketoprofen.Approved, Investigational
FluoxetineFluoxetine may increase the antiplatelet activities of Dexketoprofen.Approved, Vet Approved
FluprednideneThe risk or severity of adverse effects can be increased when Fluprednidene is combined with Dexketoprofen.Approved, Withdrawn
FluprednisoloneThe risk or severity of adverse effects can be increased when Fluprednisolone is combined with Dexketoprofen.Approved
FlurandrenolideThe risk or severity of adverse effects can be increased when Flurandrenolide is combined with Dexketoprofen.Approved
FlurbiprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Flurbiprofen.Approved, Investigational
FluticasoneThe risk or severity of adverse effects can be increased when Fluticasone is combined with Dexketoprofen.Approved, Experimental, Investigational
Fluticasone furoateThe risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Dexketoprofen.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Dexketoprofen.Approved
FluvoxamineFluvoxamine may increase the antiplatelet activities of Dexketoprofen.Approved, Investigational
FormestaneThe risk or severity of adverse effects can be increased when Formestane is combined with Dexketoprofen.Approved, Investigational, Withdrawn
FosphenytoinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Fosphenytoin.Approved, Investigational
FurosemideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Furosemide.Approved, Vet Approved
GenisteinDexketoprofen may increase the thrombogenic activities of Genistein.Investigational
GuacetisalThe risk or severity of adverse effects can be increased when Guacetisal is combined with Dexketoprofen.Experimental
HalcinonideThe risk or severity of adverse effects can be increased when Halcinonide is combined with Dexketoprofen.Approved, Investigational, Withdrawn
HE3286The risk or severity of adverse effects can be increased when HE3286 is combined with Dexketoprofen.Investigational
Hemoglobin crosfumarilThe risk or severity of adverse effects can be increased when Hemoglobin crosfumaril is combined with Dexketoprofen.Experimental
HexestrolDexketoprofen may increase the thrombogenic activities of Hexestrol.Withdrawn
HigenamineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Higenamine.Investigational
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocortisoneThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Dexketoprofen.Approved, Vet Approved
HydroflumethiazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Hydroflumethiazide.Approved, Investigational
HydroxyfasudilThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Hydroxyfasudil.Experimental
IbuprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Ibuprofen.Approved
IbuproxamThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Ibuproxam.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Icatibant.Approved, Investigational
Imidazole salicylateThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Imidazole salicylate.Experimental
IndalpineIndalpine may increase the antiplatelet activities of Dexketoprofen.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Indapamide.Approved
IndobufenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Indobufen.Investigational
IndomethacinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Indomethacin.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Indoprofen.Withdrawn
IsoxicamThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Isoxicam.Withdrawn
IstaroximeThe risk or severity of adverse effects can be increased when Istaroxime is combined with Dexketoprofen.Investigational
KebuzoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Kebuzone.Experimental
KetoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Ketoprofen.Approved, Vet Approved
KetorolacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Ketorolac.Approved
LeflunomideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Leflunomide.Approved, Investigational
LevomilnacipranLevomilnacipran may increase the antiplatelet activities of Dexketoprofen.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Lisofylline.Investigational
LonazolacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Lonazolac.Experimental
LornoxicamThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Lornoxicam.Approved, Investigational
LoteprednolThe risk or severity of adverse effects can be increased when Loteprednol is combined with Dexketoprofen.Approved
LoxoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Loxoprofen.Approved, Investigational
LumiracoxibThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Lumiracoxib.Approved, Investigational
MafenideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Mafenide.Approved, Vet Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Magnesium salicylate.Approved
MasoprocolThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Masoprocol.Approved, Investigational
ME-609The risk or severity of adverse effects can be increased when ME-609 is combined with Dexketoprofen.Investigational
MebutizideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Mebutizide.Experimental
Meclofenamic acidThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Meclofenamic acid.Approved, Vet Approved
MedrysoneThe risk or severity of adverse effects can be increased when Medrysone is combined with Dexketoprofen.Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Mefenamic acid.Approved
MefrusideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Mefruside.Experimental
MelengestrolThe risk or severity of adverse effects can be increased when Melengestrol is combined with Dexketoprofen.Vet Approved
MeloxicamThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Meloxicam.Approved, Vet Approved
MesalazineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Dexketoprofen.Approved
MestranolDexketoprofen may increase the thrombogenic activities of Mestranol.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Metamizole.Approved, Investigational, Withdrawn
MethallenestrilDexketoprofen may increase the thrombogenic activities of Methallenestril.Experimental
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Dexketoprofen.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Methyclothiazide.Approved
Methyl salicylateThe risk or severity of adverse effects can be increased when Methyl salicylate is combined with Dexketoprofen.Approved, Vet Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Methylprednisolone is combined with Dexketoprofen.Approved, Vet Approved
MetolazoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Metolazone.Approved
MifepristoneThe therapeutic efficacy of Mifepristone can be decreased when used in combination with Dexketoprofen.Approved, Investigational
MilnacipranMilnacipran may increase the antiplatelet activities of Dexketoprofen.Approved, Investigational
MizoribineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Mizoribine.Investigational
MofebutazoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Mofebutazone.Experimental
MometasoneThe risk or severity of adverse effects can be increased when Mometasone is combined with Dexketoprofen.Approved, Vet Approved
MoxestrolDexketoprofen may increase the thrombogenic activities of Moxestrol.Experimental
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Mycophenolate mofetil.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Mycophenolic acid.Approved
NabumetoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Nabumetone.Approved
NafamostatThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Nafamostat.Approved, Investigational
NaftifineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Naftifine.Approved
NaproxenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Naproxen.Approved, Vet Approved
NCX 1022The risk or severity of adverse effects can be increased when NCX 1022 is combined with Dexketoprofen.Investigational
NefazodoneNefazodone may increase the antiplatelet activities of Dexketoprofen.Approved, Withdrawn
NepafenacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Nepafenac.Approved, Investigational
NifenazoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Nifenazone.Experimental
Niflumic AcidThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Niflumic Acid.Approved
NimesulideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Nimesulide.Approved, Investigational, Withdrawn
NitroaspirinThe risk or severity of adverse effects can be increased when Nitroaspirin is combined with Dexketoprofen.Investigational
Oleoyl-estroneThe risk or severity of adverse effects can be increased when Oleoyl-estrone is combined with Dexketoprofen.Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Olopatadine.Approved
OlsalazineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Olsalazine.Approved
OrgoteinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Orgotein.Vet Approved
OxaprozinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Oxaprozin.Approved
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Oxyphenbutazone.Approved, Withdrawn
ParamethasoneThe risk or severity of adverse effects can be increased when Paramethasone is combined with Dexketoprofen.Approved
ParecoxibThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Parecoxib.Approved
ParoxetineParoxetine may increase the antiplatelet activities of Dexketoprofen.Approved, Investigational
ParthenolideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Parthenolide.Approved, Investigational
PhenindioneDexketoprofen may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenprocoumonDexketoprofen may increase the anticoagulant activities of Phenprocoumon.Approved, Investigational
Phenyl aminosalicylateThe risk or severity of adverse effects can be increased when Phenyl aminosalicylate is combined with Dexketoprofen.Approved
PhenylbutazoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Phenylbutazone.Approved, Vet Approved
PhenytoinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Phenytoin.Approved, Vet Approved
PhthalylsulfathiazoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Phthalylsulfathiazole.Experimental
PimecrolimusThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Pimecrolimus.Approved, Investigational
PipazethateThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Pipazethate.Approved
PirfenidoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Pirfenidone.Approved, Investigational
PiroxicamThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Piroxicam.Approved, Investigational
PirprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Pirprofen.Experimental
Polyestradiol phosphateDexketoprofen may increase the thrombogenic activities of Polyestradiol phosphate.Approved
PolythiazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Polythiazide.Approved
PranoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Pranoprofen.Experimental, Investigational
PrasteroneThe risk or severity of adverse effects can be increased when Prasterone is combined with Dexketoprofen.Approved, Investigational, Nutraceutical
Prasterone sulfateThe risk or severity of adverse effects can be increased when Prasterone sulfate is combined with Dexketoprofen.Investigational
PrednicarbateThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Dexketoprofen.Approved, Investigational
PrednisoloneThe risk or severity of adverse effects can be increased when Prednisolone is combined with Dexketoprofen.Approved, Vet Approved
PrednisoneThe risk or severity of adverse effects can be increased when Prednisone is combined with Dexketoprofen.Approved, Vet Approved
PregnenoloneThe risk or severity of adverse effects can be increased when Pregnenolone is combined with Dexketoprofen.Approved, Experimental, Investigational
ProbenecidThe serum concentration of Dexketoprofen can be increased when it is combined with Probenecid.Approved, Investigational
ProglumetacinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Proglumetacin.Experimental
PromestrieneDexketoprofen may increase the thrombogenic activities of Promestriene.Investigational
PropacetamolThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Propacetamol.Approved, Investigational
PropyphenazoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Propyphenazone.Experimental
ProquazoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Proquazone.Experimental
PTC299The risk or severity of adverse effects can be increased when Dexketoprofen is combined with PTC299.Investigational
QuinestrolDexketoprofen may increase the thrombogenic activities of Quinestrol.Approved
ResveratrolThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Resveratrol.Approved, Experimental, Investigational
RimexoloneThe risk or severity of adverse effects can be increased when Rimexolone is combined with Dexketoprofen.Approved
RofecoxibThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Rofecoxib.Approved, Investigational, Withdrawn
RosuvastatinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Rosuvastatin.Approved
SalicylamideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Salicylamide.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Dexketoprofen.Approved, Investigational, Vet Approved
SalsalateThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Salsalate.Approved
SecoisolariciresinolDexketoprofen may increase the thrombogenic activities of Secoisolariciresinol.Investigational
SemapimodThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Semapimod.Investigational
SeratrodastThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Seratrodast.Approved
SerrapeptaseThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Serrapeptase.Investigational
SertralineSertraline may increase the antiplatelet activities of Dexketoprofen.Approved
SetrobuvirThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Setrobuvir.Investigational
SildenafilThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sildenafil.Approved, Investigational
Silver sulfadiazineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Silver sulfadiazine.Approved, Vet Approved
SimeprevirThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Simeprevir.Approved
SRT501The risk or severity of adverse effects can be increased when Dexketoprofen is combined with SRT501.Investigational
SuccinylsulfathiazoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Succinylsulfathiazole.Experimental
SulfacetamideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfacetamide.Approved
SulfachlorpyridazineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfachlorpyridazine.Vet Approved
SulfacytineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfacytine.Approved
SulfadiazineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfadiazine.Approved, Investigational, Vet Approved
SulfadicramideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfadicramide.Experimental
SulfadimethoxineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfadimethoxine.Approved, Vet Approved
SulfadoxineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfadoxine.Approved, Investigational
SulfaethoxypyridazineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfaethoxypyridazine.Vet Approved
SulfaguanidineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfaguanidine.Experimental
SulfaisodimidineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfaisodimidine.Experimental
SulfamerazineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfamerazine.Approved, Vet Approved
SulfameterThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfameter.Approved
SulfamethazineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfamethazine.Approved, Investigational, Vet Approved
SulfamethizoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfamethizole.Approved, Investigational, Vet Approved
SulfamethoxazoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfamethoxazole.Approved
SulfamethoxypyridazineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfamethoxypyridazine.Experimental
SulfametopyrazineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfametopyrazine.Approved, Withdrawn
SulfamoxoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfamoxole.Approved
SulfanilamideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfanilamide.Approved
SulfanitranThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfanitran.Vet Approved
SulfaphenazoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfaphenazole.Approved
SulfapyridineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfapyridine.Approved
SulfaquinoxalineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfaquinoxaline.Vet Approved
SulfasalazineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfasalazine.Approved
SulfathiazoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfathiazole.Approved, Vet Approved
SulfathioureaThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfathiourea.Experimental
SulfatolamideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfatolamide.Experimental
SulfisoxazoleThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfisoxazole.Approved, Vet Approved
SulindacThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulindac.Approved, Investigational
SumatriptanThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sumatriptan.Approved, Investigational
SuprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Suprofen.Approved, Withdrawn
SuxibuzoneThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Suxibuzone.Experimental
Synthetic Conjugated Estrogens, ADexketoprofen may increase the thrombogenic activities of Synthetic Conjugated Estrogens, A.Approved
Synthetic Conjugated Estrogens, BDexketoprofen may increase the thrombogenic activities of Synthetic Conjugated Estrogens, B.Approved
TarenflurbilThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Tarenflurbil.Investigational
TenidapThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Tenidap.Experimental
TenoxicamThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Tenoxicam.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Tepoxalin.Vet Approved
TeriflunomideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Teriflunomide.Approved
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Tiaprofenic acid.Approved
TiboloneDexketoprofen may increase the thrombogenic activities of Tibolone.Approved, Investigational
TinoridineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Tinoridine.Investigational
TioclomarolDexketoprofen may increase the anticoagulant activities of Tioclomarol.Experimental
TixocortolThe risk or severity of adverse effects can be increased when Tixocortol is combined with Dexketoprofen.Approved, Withdrawn
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Tolfenamic Acid.Approved, Investigational
TolmetinThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Tolmetin.Approved
TranilastThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Tranilast.Approved, Investigational
TriamcinoloneThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Dexketoprofen.Approved, Vet Approved
TribenosideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Tribenoside.Experimental
TrichlormethiazideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Trichlormethiazide.Approved, Vet Approved
TriptolideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Triptolide.Investigational
Trolamine salicylateThe risk or severity of adverse effects can be increased when Trolamine salicylate is combined with Dexketoprofen.Approved
UlobetasolThe risk or severity of adverse effects can be increased when Ulobetasol is combined with Dexketoprofen.Approved
ValdecoxibThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Valdecoxib.Approved, Investigational, Withdrawn
VenlafaxineVenlafaxine may increase the antiplatelet activities of Dexketoprofen.Approved
WarfarinDexketoprofen may increase the anticoagulant activities of Warfarin.Approved
XipamideThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Xipamide.Experimental
ZaltoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Zaltoprofen.Approved, Investigational
ZeranolDexketoprofen may increase the thrombogenic activities of Zeranol.Vet Approved
ZidovudineThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Zidovudine.Approved
ZileutonThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Zileuton.Approved, Investigational, Withdrawn
ZimelidineZimelidine may increase the antiplatelet activities of Dexketoprofen.Withdrawn
ZomepiracThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Zomepirac.Withdrawn
Food Interactions
Not Available

References

General References
  1. Valles J, Artigas R, Crea A, Muller F, Paredes I, Zapata A, Capriati A: Clinical pharmacokinetics of parenteral dexketoprofen trometamol in healthy subjects. Methods Find Exp Clin Pharmacol. 2006 Jun;28 Suppl A:7-12. [PubMed:16801987]
  2. Dexketoprofen [Link]
  3. Concise info Dexketoprofen [Link]
  4. DEXKETOPROFEN [Link]
  5. PRECLINICAL AND CLINCIAL DEVELOPMENT OF DEXOKETOPROFEN [Link]
  6. Dexktoprofen drug insert [Link]
  7. Dexketoprofen information [Link]
  8. Analgesic properties of dexketoprofen trometamol [Link]
External Links
Human Metabolome Database
HMDB0041873
KEGG Drug
D07269
PubChem Compound
667550
PubChem Substance
310265121
ChemSpider
580922
BindingDB
50088570
ChEBI
76128
ChEMBL
CHEMBL75435
PharmGKB
PA166049175
Wikipedia
Dexketoprofen
ATC Codes
M02AA27 — DexketoprofenM01AE17 — Dexketoprofen

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailablePain, Acute1
3Active Not RecruitingTreatmentPostoperative pain1
3CompletedTreatmentPain, Acute2
4CompletedPreventionInjection Pain1
4CompletedTreatmentLow Back Pain (LBP)1
4CompletedTreatmentMigraine, Acute1
4CompletedTreatmentMigraines1
4CompletedTreatmentPostoperative pain2
4CompletedTreatmentPainful musculoskeletal conditions2
4Not Yet RecruitingTreatmentSupratentorial Neoplasms1
4RecruitingTreatmentNo Reconstructive Breast Surgery1
4Unknown StatusTreatmentDysmenorrhea1
Not AvailableCompletedTreatmentKnee Osteoarthritis (Knee OA)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)75[L1300]
boiling point (°C)431.32[L1300]
Predicted Properties
PropertyValueSource
Water Solubility0.0213 mg/mLALOGPS
logP3.29ALOGPS
logP3.61ChemAxon
logS-4.1ALOGPS
pKa (Strongest Acidic)3.88ChemAxon
pKa (Strongest Basic)-7.5ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area54.37 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity72.52 m3·mol-1ChemAxon
Polarizability26.88 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-3910000000-1bfe148d4ab6af381e80

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzophenones
Direct Parent
Benzophenones
Alternative Parents
Diphenylmethanes / Aryl-phenylketones / Phenylpropanoic acids / Benzoyl derivatives / Monocarboxylic acids and derivatives / Carboxylic acids / Organic oxides / Hydrocarbon derivatives
Substituents
Benzophenone / Aryl-phenylketone / Diphenylmethane / 2-phenylpropanoic-acid / Benzoyl / Aryl ketone / Ketone / Carboxylic acid derivative / Carboxylic acid / Monocarboxylic acid or derivatives
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
benzophenones, monocarboxylic acid (CHEBI:76128)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gas...
Gene Name
PTGS1
Uniprot ID
P23219
Uniprot Name
Prostaglandin G/H synthase 1
Molecular Weight
68685.82 Da
References
  1. Analgesic properties of dexketoprofen trometamol [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name
PTGS2
Uniprot ID
P35354
Uniprot Name
Prostaglandin G/H synthase 2
Molecular Weight
68995.625 Da
References
  1. Analgesic properties of dexketoprofen trometamol [Link]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gas...
Gene Name
PTGS1
Uniprot ID
P23219
Uniprot Name
Prostaglandin G/H synthase 1
Molecular Weight
68685.82 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name
PTGS2
Uniprot ID
P35354
Uniprot Name
Prostaglandin G/H synthase 2
Molecular Weight
68995.625 Da

Drug created on October 21, 2015 09:57 / Updated on July 02, 2018 19:13