Chronic Bronchitis

Also known as: Bronchitis chronic / Bronchitis, Chronic / Chronic bronchitis NOS / Chronic bronchitis, unspecified / Bronchitis chronic NOS / Unspecified chronic bronchitis

DrugDrug NameDrug Description
DB01223AminophyllineAminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply.
DB00588Fluticasone propionateFluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990[L5962].
DB00332IpratropiumIpratropium is a quaternary ammonium derivative of [atropine][A176957] that acts as an anticholinergic agent.[A176939] It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption.[A176957] Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its first monotherapy product was FDA approved in 1986.[L5891] On the other hand, the combination product of ipratropium and [albuterol] was approved in 1996.[L5894]
DB00816OrciprenalineA beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem]
DB01303OxtriphyllineOxtriphylline is the choline salt form of [theophylline]. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all the same indications as the other theophyllines). It is marketed under the name Choledyl SA, and several forms of oxytriphylline have been discontinued. In the US, oxtriphylline is no longer available.
DB00277TheophyllineA methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
DrugDrug NameTargetType
DB01223AminophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB01223AminophyllineAdenosine receptor A3target
DB01223AminophyllineAdenosine receptor A1target
DB01223AminophyllineCytochrome P450 1A2enzyme
DB01223AminophyllineCytochrome P450 2E1enzyme
DB01223AminophyllineCytochrome P450 3A4enzyme
DB01223AminophyllineHistone deacetylase 2target
DB01223AminophyllineCytochrome P450 2C19enzyme
DB00588Fluticasone propionateCorticosteroid-binding globulincarrier
DB00588Fluticasone propionateCytosolic phospholipase A2target
DB00588Fluticasone propionateGlucocorticoid receptortarget
DB00588Fluticasone propionateCytochrome P450 3A4enzyme
DB00588Fluticasone propionateProgesterone receptortarget
DB00588Fluticasone propionateMineralocorticoid receptortarget
DB00588Fluticasone propionateCytochrome P450 3A5enzyme
DB00588Fluticasone propionateCytochrome P450 3A7enzyme
DB00588Fluticasone propionateCytochrome P450 2C8enzyme
DB00588Fluticasone propionateMultidrug resistance protein 1carrier
DB00588Fluticasone propionateSolute carrier organic anion transporter family member 1B1carrier
DB00332IpratropiumMuscarinic acetylcholine receptor M1target
DB00332IpratropiumMuscarinic acetylcholine receptor M2target
DB00332IpratropiumMuscarinic acetylcholine receptor M3target
DB00332IpratropiumSolute carrier family 22 member 5transporter
DB00332IpratropiumSolute carrier family 22 member 4transporter
DB00332IpratropiumSerum albumincarrier
DB00332Ipratropiumalpha1-acid glycoproteincarrier
DB00816OrciprenalineBeta-2 adrenergic receptortarget
DB01303OxtriphyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB01303OxtriphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB01303OxtriphyllineAdenosine receptor A2atarget
DB01303OxtriphyllineAdenosine receptor A1target
DB01303OxtriphyllineCytochrome P450 1A2enzyme
DB01303OxtriphyllineSolute carrier family 22 member 7transporter
DB01303OxtriphyllineHistone deacetylase 2target
DB00277TheophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00277TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00277TheophyllineAdenosine receptor A2btarget
DB00277TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB00277TheophyllinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB00277TheophyllineAdenosine receptor A1target
DB00277TheophyllineAdenosine receptor A2atarget
DB00277TheophyllineCytochrome P450 1A2enzyme
DB00277TheophyllineAdenosine deaminaseenzyme
DB00277TheophyllineCytochrome P450 2E1enzyme
DB00277TheophyllineCytochrome P450 3A4enzyme
DB00277TheophyllineSolute carrier family 22 member 7transporter
DB00277TheophyllineCytochrome P450 1A1enzyme
DB00277TheophyllineCytochrome P450 1B1enzyme
DB00277TheophyllineCytochrome P450 2C8enzyme
DB00277TheophyllineCytochrome P450 2D6enzyme
DB00277TheophyllineHistone deacetylase 2target
DB00277TheophyllineCopine-1target
DB00277TheophyllineMinor histocompatibility antigen H13target
DB00277TheophyllineNodal modulator 1target
DB00277TheophyllinePoly [ADP-ribose] polymerase 1target
DB00277TheophyllineProtein RIC-3target
DB00277TheophyllineTubulin monoglycylase TTLL3target
DrugDrug NamePhaseStatusCount
DB01409Tiotropium0Completed1
DB06151Acetylcysteine2Completed1
DB00207Azithromycin2Terminated1
DB05057Erdosteine2Completed1
DB00588Fluticasone propionate2Terminated1
DB08820Ivacaftor2Recruiting1
DB13973Remestemcel-L2Completed1
DB00296Ropivacaine2Completed1
DB01137Levofloxacin2 / 3Completed1
DB01274Arformoterol3Completed2
DB00207Azithromycin3Completed2
DB05659Faropenem medoxomil3Terminated1
DB01137Levofloxacin3Completed2
DB00218Moxifloxacin3Completed2
DB00938Salmeterol3Completed2
DB06151Acetylcysteine4Completed1
DB01274Arformoterol4Unknown Status1
DB00207Azithromycin4Terminated1
DB00207Azithromycin4Withdrawn1
DB00588Fluticasone propionate4Completed1
DB00983Formoterol4Withdrawn1
DB08820Ivacaftor4Not Yet Recruiting1
DB00678Losartan4Unknown Status1
DB00218Moxifloxacin4Completed1
DB01656Roflumilast4Completed1
DB00938Salmeterol4Unknown Status1
DB00976Telithromycin4Completed2
DB00976Telithromycin4Terminated2
DB00976Telithromycin4Withdrawn1
DB01409Tiotropium4Completed1
DB06151AcetylcysteineNot AvailableTerminated1
DB06151AcetylcysteineNot AvailableUnknown Status1
DB00479AmikacinNot AvailableCompleted1
DB00438CeftazidimeNot AvailableCompleted1
DB00678LosartanNot AvailableRecruiting1
DB00760MeropenemNot AvailableCompleted1
DB00218MoxifloxacinNot AvailableCompleted4
DB01001SalbutamolNot AvailableCompleted1
DB00684TobramycinNot AvailableCompleted1