Secondary Myelofibrosis

Drug	Drug Name	Drug Description
DB12500	Fedratinib	Fedratinib is indicated to treat adults with primary or secondary myelofibrosis that is either intermediate-2 or high risk.

Drug	Drug Name	Target	Type
DB12500	Fedratinib	P-glycoprotein 1	transporter
DB12500	Fedratinib	ATP-binding cassette sub-family G member 2	transporter
DB12500	Fedratinib	Solute carrier organic anion transporter family member 1B1	transporter
DB12500	Fedratinib	Solute carrier organic anion transporter family member 1B3	transporter
DB12500	Fedratinib	POU domain, class 2, transcription factor 2	transporter
DB12500	Fedratinib	Multidrug and toxin extrusion protein 1	transporter
DB12500	Fedratinib	Multidrug and toxin extrusion protein 2	transporter
DB12500	Fedratinib	Cytochrome P450 3A4	enzyme
DB12500	Fedratinib	Cytochrome P450 2C19	enzyme
DB12500	Fedratinib	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
DB12500	Fedratinib	Tyrosine-protein kinase JAK2	target
DB12500	Fedratinib	Receptor-type tyrosine-protein kinase FLT3	target
DB12500	Fedratinib	Tyrosine-protein kinase JAK1	target
DB12500	Fedratinib	Cytochrome P450 2D6	enzyme

Drug	Drug Name	Phase	Status	Count
DB00531	Cyclophosphamide	0	Recruiting	1
DB00099	Filgrastim	0	Recruiting	1
DB01073	Fludarabine	0	Recruiting	1
DB00888	Mechlorethamine	0	Recruiting	1
DB00688	Mycophenolate mofetil	0	Recruiting	1
DB00642	Pemetrexed	0	Active Not Recruiting	1
DB00864	Tacrolimus	0	Recruiting	1
DB00531	Cyclophosphamide	1	Recruiting	1
DB00531	Cyclophosphamide	1	Terminated	1
DB00091	Cyclosporine	1	Terminated	1
DB00099	Filgrastim	1	Recruiting	1
DB01073	Fludarabine	1	Active Not Recruiting	1
DB01073	Fludarabine	1	Recruiting	1
DB01073	Fludarabine	1	Terminated	1
DB01073	Fludarabine	1	Withdrawn	1
DB00888	Mechlorethamine	1	Active Not Recruiting	1
DB00888	Mechlorethamine	1	Recruiting	1
DB00888	Mechlorethamine	1	Withdrawn	1
DB00688	Mycophenolate mofetil	1	Recruiting	1
DB00688	Mycophenolate mofetil	1	Terminated	1
DB08877	Ruxolitinib	1	Active Not Recruiting	1
DB08877	Ruxolitinib	1	Withdrawn	1
DB00877	Sirolimus	1	Active Not Recruiting	1
DB00877	Sirolimus	1	Withdrawn	1
DB00864	Tacrolimus	1	Active Not Recruiting	1
DB00864	Tacrolimus	1	Recruiting	1
DB00864	Tacrolimus	1	Withdrawn	1
DB08910	Pomalidomide	1 / 2	Completed	1
DB08910	Pomalidomide	1 / 2	Recruiting	1
DB08877	Ruxolitinib	1 / 2	Recruiting	1
DB09312	Antilymphocyte immunoglobulin (horse)	2	Completed	1
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Completed	1
DB00928	Azacitidine	2	Terminated	1
DB01008	Busulfan	2	Completed	2
DB01008	Busulfan	2	Not Yet Recruiting	1
DB01008	Busulfan	2	Recruiting	1
DB01008	Busulfan	2	Terminated	1
DB00531	Cyclophosphamide	2	Completed	4
DB00531	Cyclophosphamide	2	Not Yet Recruiting	2
DB00531	Cyclophosphamide	2	Recruiting	1
DB00531	Cyclophosphamide	2	Terminated	1
DB00531	Cyclophosphamide	2	Unknown Status	1
DB00091	Cyclosporine	2	Completed	1
DB01406	Danazol	2	Completed	1
DB01262	Decitabine	2	Active Not Recruiting	1
DB01262	Decitabine	2	Recruiting	1
DB01262	Decitabine	2	Terminated	1
DB01609	Deferasirox	2	Completed	1
DB00773	Etoposide	2	Completed	1
DB12500	Fedratinib	2	Not Yet Recruiting	1
DB12500	Fedratinib	2	Recruiting	1
DB00099	Filgrastim	2	Not Yet Recruiting	1
DB01073	Fludarabine	2	Completed	2
DB01073	Fludarabine	2	Not Yet Recruiting	3
DB01073	Fludarabine	2	Recruiting	1
DB01073	Fludarabine	2	Terminated	1
DB05036	Grn163l	2	Completed	1
DB14909	Imetelstat	2	Completed	1
DB05258	Interferon alfa	2	Recruiting	1
DB12085	LCL-161	2	Active Not Recruiting	1
DB00888	Mechlorethamine	2	Not Yet Recruiting	3
DB00888	Mechlorethamine	2	Recruiting	1
DB01042	Melphalan	2	Completed	2
DB00563	Methotrexate	2	Completed	2
DB00563	Methotrexate	2	Not Yet Recruiting	1
DB00563	Methotrexate	2	Recruiting	1
DB00959	Methylprednisolone	2	Completed	1
DB14644	Methylprednisolone hemisuccinate	2	Completed	1
DB00688	Mycophenolate mofetil	2	Completed	3
DB00688	Mycophenolate mofetil	2	Not Yet Recruiting	2
DB00688	Mycophenolate mofetil	2	Recruiting	1
DB00635	Prednisone	2	Completed	1
DB00172	Proline	2	Recruiting	1
DB15119	Ropeginterferon alfa-2b	2	Recruiting	1
DB06164	Ruxolitinib	2	Completed	1
DB08877	Ruxolitinib	2	Completed	1
DB08877	Ruxolitinib	2	Not Yet Recruiting	2
DB08877	Ruxolitinib	2	Recruiting	2
DB00877	Sirolimus	2	Completed	1
DB00877	Sirolimus	2	Not Yet Recruiting	1
DB00864	Tacrolimus	2	Completed	3
DB00864	Tacrolimus	2	Not Yet Recruiting	3
DB00864	Tacrolimus	2	Recruiting	1
DB00864	Tacrolimus	2	Unknown Status	1
DB01041	Thalidomide	2	Completed	1
DB00099	Filgrastim	3	Completed	1
DB01008	Busulfan	Not Available	Completed	1
DB01008	Busulfan	Not Available	No Longer Available	1
DB00531	Cyclophosphamide	Not Available	Completed	1
DB00987	Cytarabine	Not Available	No Longer Available	1
DB01073	Fludarabine	Not Available	No Longer Available	1
DB00529	Foscarnet	Not Available	Completed	1
DB01004	Ganciclovir	Not Available	Completed	1
DB00563	Methotrexate	Not Available	Completed	1
DB00688	Mycophenolate mofetil	Not Available	No Longer Available	1
DB00864	Tacrolimus	Not Available	Completed	1
DB00864	Tacrolimus	Not Available	No Longer Available	1
DB01610	Valganciclovir	Not Available	Completed	1