Glucocorticoid receptor

Details

Name
Glucocorticoid receptor
Synonyms
  • GR
  • GRL
  • Nuclear receptor subfamily 3 group C member 1
Gene Name
NR3C1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001584|Glucocorticoid receptor
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
Number of residues
777
Molecular Weight
85658.57
Theoretical pI
6.31
GO Classification
Functions
glucocorticoid receptor activity / glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity / RNA polymerase II core promoter proximal region sequence-specific DNA binding / steroid binding / steroid hormone binding / transcription factor activity, sequence-specific DNA binding / transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding / zinc ion binding
Processes
cellular response to steroid hormone stimulus / chromatin modification / gene expression / positive regulation of transcription from RNA polymerase II promoter / regulation of transcription, DNA-templated / signal transduction / transcription from RNA polymerase II promoter / transcription initiation from RNA polymerase II promoter / transcription, DNA-templated
Components
cytoplasm / mitochondrial matrix / nucleoplasm / nucleus
General Function
Zinc ion binding
Specific Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0020486|Glucocorticoid receptor (NR3C1)
ATGGACTCCAAAGAATCATTAACTCCTGGTAGAGAAGAAAACCCCAGCAGTGTGCTTGCT
CAGGAGAGGGGAGATGTGATGGACTTCTATAAAACCCTAAGAGGAGGAGCTACTGTGAAG
GTTTCTGCGTCTTCACCCTCACTGGCTGTCGCTTCTCAATCAGACTCCAAGCAGCGAAGA
CTTTTGGTTGATTTTCCAAAAGGCTCAGTAAGCAATGCGCAGCAGCCAGATCTGTCCAAA
GCAGTTTCACTCTCAATGGGACTGTATATGGGAGAGACAGAAACAAAAGTGATGGGAAAT
GACCTGGGATTCCCACAGCAGGGCCAAATCAGCCTTTCCTCGGGGGAAACAGACTTAAAG
CTTTTGGAAGAAAGCATTGCAAACCTCAATAGGTCGACCAGTGTTCCAGAGAACCCCAAG
AGTTCAGCATCCACTGCTGTGTCTGCTGCCCCCACAGAGAAGGAGTTTCCAAAAACTCAC
TCTGATGTATCTTCAGAACAGCAACATTTGAAGGGCCAGACTGGCACCAACGGTGGCAAT
GTGAAATTGTATACCACAGACCAAAGCACCTTTGACATTTTGCAGGATTTGGAGTTTTCT
TCTGGGTCCCCAGGTAAAGAGACGAATGAGAGTCCTTGGAGATCAGACCTGTTGATAGAT
GAAAACTGTTTGCTTTCTCCTCTGGCGGGAGAAGACGATTCATTCCTTTTGGAAGGAAAC
TCGAATGAGGACTGCAAGCCTCTCATTTTACCGGACACTAAACCCAAAATTAAGGATAAT
GGAGATCTGGTTTTGTCAAGCCCCAGTAATGTAACACTGCCCCAAGTGAAAACAGAAAAA
GAAGATTTCATCGAACTCTGCACCCCTGGGGTAATTAAGCAAGAGAAACTGGGCACAGTT
TACTGTCAGGCAAGCTTTCCTGGAGCAAATATAATTGGTAATAAAATGTCTGCCATTTCT
GTTCATGGTGTGAGTACCTCTGGAGGACAGATGTACCACTATGACATGAATACAGCATCC
CTTTCTCAACAGCAGGATCAGAAGCCTATTTTTAATGTCATTCCACCAATTCCCGTTGGT
TCCGAAAATTGGAATAGGTGCCAAGGATCTGGAGATGACAACTTGACTTCTCTGGGGACT
CTGAACTTCCCTGGTCGAACAGTTTTTTCTAATGGCTATTCAAGCCCCAGCATGAGACCA
GATGTAAGCTCTCCTCCATCCAGCTCCTCAACAGCAACAACAGGACCACCTCCCAAACTC
TGCCTGGTGTGCTCTGATGAAGCTTCAGGATGTCATTATGGAGTCTTAACTTGTGGAAGC
TGTAAAGTTTTCTTCAAAAGAGCAGTGGAAGGACAGCACAATTACCTATGTGCTGGAAGG
AATGATTGCATCATCGATAAAATTCGAAGAAAAAACTGCCCAGCATGCCGCTATCGAAAA
TGTCTTCAGGCTGGAATGAACCTGGAAGCTCGAAAAACAAAGAAAAAAATAAAAGGAATT
CAGCAGGCCACTACAGGAGTCTCACAAGAAACCTCTGAAAATCCTGGTAACAAAACAATA
GTTCCTGCAACGTTACCACAACTCACCCCTACCCTGGTGTCACTGTTGGAGGTTATTGAA
CCTGAAGTGTTATATGCAGGATATGATAGCTCTGTTCCAGACTCAACTTGGAGGATCATG
ACTACGCTCAACATGTTAGGAGGGCGGCAAGTGATTGCAGCAGTGAAATGGGCAAAGGCA
ATACCAGGTTTCAGGAACTTACACCTGGATGACCAAATGACCCTACTGCAGTACTCCTGG
ATGTTTCTTATGGCATTTGCTCTGGGGTGGAGATCATATAGACAATCAAGTGCAAACCTG
CTGTGTTTTGCTCCTGATCTGATTATTAATGAGCAGAGAATGACTCTACCCTGCATGTAC
GACCAATGTAAACACATGCTGTATGTTTCCTCTGAGTTACACAGGCTTCAGGTATCTTAT
GAAGAGTATCTCTGTATGAAAACCTTACTGCTTCTCTCTTCAGTTCCTAAGGACGGTCTG
AAGAGCCAAGAGCTATTTGATGAAATTAGAATGACCTACATCAAAGAGCTAGGAAAAGCC
ATTGTCAAGAGGGAAGGAAACTCCAGCCAGAACTGGCAGCGGTTTTATCAACTGACAAAA
CTCTTGGATTCTATGCATGAAGTGGTTGAAAATCTCCTTAACTATTGCTTCCAAACATTT
TTGGATAAGACCATGAGTATTGAATTCCCCGAGATGTTAGCTGAAATCATCACCAATCAG
ATACCAAAATATTCAAATGGAAATATCAAAAAACTTCTGTTTCATCAAAAGTGA
Chromosome Location
5
Locus
5q31.3
External Identifiers
ResourceLink
UniProtKB IDP04150
UniProtKB Entry NameGCR_HUMAN
GenBank Protein ID31680
GenBank Gene IDX03225
GenAtlas IDNR3C1
HGNC IDHGNC:7978
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00288AmcinonideapprovedyesagonistDetails
DB00443Betamethasoneapproved, vet_approvedyesagonistDetails
DB00635Prednisoneapproved, vet_approvedyesagonistDetails
DB00764Mometasoneapproved, vet_approvedyesagonistDetails
DB00959Methylprednisoloneapproved, vet_approvedyesagonistDetails
DB01222BudesonideapprovedyesantagonistDetails
DB01234Dexamethasoneapproved, investigational, vet_approvedyesagonistDetails
DB00741Hydrocortisoneapproved, vet_approvedyesagonistDetails
DB00769HydrocortamateapprovedyesagonistDetails
DB14596Loteprednol etabonateapprovedyesagonistDetails
DB00588Fluticasone propionateapprovedyesagonistDetails
DB00834Mifepristoneapproved, investigationalyesantagonistDetails
DB02210Hexane-1,6-DiolexperimentalunknownDetails
DB00180Flunisolideapproved, investigationalyesagonistDetails
DB00663Flumethasoneapproved, vet_approvedyesagonistDetails
DB05423ORG-34517investigationalunknownDetails
DB01410Ciclesonideapproved, investigationalyesagonistDetails
DB00351Megestrol acetateapproved, investigational, vet_approvedunknownagonistDetails
DB01130Prednicarbateapproved, investigationalyesagonistDetails
DB00860Prednisoloneapproved, vet_approvedyesagonistDetails
DB01185Fluoxymesteroneapproved, illicitunknownantagonistDetails
DB00591Fluocinolone acetonideapproved, investigational, vet_approvedyesagonistDetails
DB00846FlurandrenolideapprovedyesagonistDetails
DB00394Beclomethasone dipropionateapproved, investigationalyesagonistDetails
DB00687Fludrocortisoneapproved, investigationalunknownagonistDetails
DB00620Triamcinoloneapproved, vet_approvedyesagonistDetails
DB01013Clobetasol propionateapprovedyesagonistDetails
DB00838ClocortoloneapprovedyesagonistDetails
DB00547DesoximetasoneapprovedyesagonistDetails
DB00896RimexoloneapprovedyesagonistDetails
DB00596UlobetasolapprovedyesagonistDetails
DB00253MedrysoneapprovedyesagonistDetails
DB00240AlclometasoneapprovedyesagonistDetails
DB01260Desonideapproved, investigationalyesagonistDetails
DB00223DiflorasoneapprovedyesagonistDetails
DB01047Fluocinonideapproved, investigationalyesagonistDetails
DB01384ParamethasoneexperimentalyesagonistDetails
DB06781DifluprednateapprovedyesagonistDetails
DB01380Cortisone acetateapproved, investigationalyesagonistDetails
DB00324Fluorometholoneapproved, investigationalyesagonistDetails
DB08867UlipristalapprovedyesantagonistDetails
DB08906Fluticasone furoateapprovedyesagonistDetails
DB00421SpironolactoneapprovedunknownantagonistDetails
DB13158ClobetasoneapprovedyesagonistDetails
DB04630Aldosteroneexperimental, investigationalunknownDetails
DB13003CortivazolinvestigationalunknownDetails
DB12637OnapristoneinvestigationalunknownDetails
DB00396Progesteroneapproved, vet_approvedunknownpartial agonistDetails
DB09091Tixocortolapproved, withdrawnyesbinderDetails
DB09095Difluocortoloneapproved, investigational, withdrawnyesbinderDetails
DB11619GestrinoneapprovedunknownantagonistDetails
DB14512Mometasone furoateapproved, investigational, vet_approvedyesDetails
DB14538Hydrocortisone aceponateexperimental, vet_approvedyesDetails
DB14539Hydrocortisone acetateapproved, vet_approvedyesDetails
DB14540Hydrocortisone butyrateapproved, vet_approvedyesDetails
DB14541Hydrocortisone cypionateapproved, investigational, vet_approvedyesDetails
DB14542Hydrocortisone phosphateapproved, vet_approvedyesDetails
DB14543Hydrocortisone probutateapproved, vet_approvedyesDetails
DB14544Hydrocortisone valerateapproved, vet_approvedyesDetails
DB14583Segesterone acetateapproved, experimental, investigationalnoagonistDetails
DB13867Fluticasoneapproved, experimentalyesagonistDetails
DB11921Deflazacortapproved, investigationalunknownagonistDetails
DB00367Levonorgestrelapproved, investigationalunknownbinderDetails
DB01395DrospirenoneapprovedunknownbinderDetails
DB15566Prednisolone acetateapproved, vet_approvedyesagonistDetails
DB00717NorethisteroneapprovedunknownagonistDetails