Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Did you mean mk 4307 of suvorexant of mk 4307 of スボレキサント?
Displaying drugs 201 - 225 of 8049 in total

Abacavir

Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Approved
Investigational
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Daclatasvir

Daclatasvir is a direct-acting antiviral agent against Hepatitis C Virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection. It is marketed under the name DAKLINZA and is contained in daily oral tablets as the hydrochloride salt form . Hepatitis C is an infectious liver disease...
Approved
Investigational
Matched Description: … Binding to the N-terminus of the D1 domain of NS5A prevents its interaction with host cell proteins and ... According to 2017 American Association for the Study of Liver Diseases (AASLD), 60mg of daclatasvir is ... reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma …
Matched Categories: … Antivirals for treatment of HCV infections …

Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and...
Approved
Matched Description: … non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of ... [A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development ... the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of …
Matched Products: … IBUPROFENO MK RETARD 400 MG ... IBUPROFENO MK 400 MG GRAGEAS …

Ritonavir

Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a...
Approved
Investigational
Matched Description: … American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America ... Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. ... It is now more commonly used as a booster of other protease inhibitors and is available in both liquid …
Matched Categories: … Antivirals for treatment of HCV infections ... Metabolic Side Effects of Drugs and Substances ... Antivirals used in combination for the treatment of HIV infections …

Fenfluramine

Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients typically display delayed development and neurocognitive impairment.[A214694, A214709, A214712,...
Approved
Illicit
Investigational
Withdrawn
Matched Description: … Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life ... in 1973 prior to its withdrawal; it was granted a new FDA approval on June 25, 2020, for treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Lisuride

An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists).
Approved
Investigational
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Tinidazole

A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.
Approved
Investigational
Matched Categories: … combinations of imidazole derivatives …

Fluocinolone acetonide

Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity. It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices. This type of device containing fluocinolone acetonide was developed by Taro...
Approved
Investigational
Vet approved
Matched Description: … [T358] This type of device containing fluocinolone acetonide was developed by Taro Pharmaceuticals and …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Rizatriptan

Rizatriptan is a second-generation triptan and a selective 5-HT1B and 5-HT1D receptor agonist. Used in the treatment of migraines, rizatriptan was first approved in the US in 1998. Rizatriptan is available in oral tablets, orally disintegrating tablets (wafers), and oral film formulations.
Approved
Matched Description: … [L46018] Used in the treatment of migraines, rizatriptan was first approved in the US in 1998. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Norfloxacin

A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Elvitegravir

Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome and thereby blocks the formation of the...
Approved
Matched Description: … of the viral infection. ... On September 24, 2014, the FDA approved the single pill form of elvitegravir. ... immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Dienogest

Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not...
Approved
Matched Description: … It is a derivative of 19-nortestosterone and has antiandrogenic properties. ... , dienogest single therapy is an approved treatment for endometriosis to alleviate painful symptoms of ... Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Brexpiprazole

Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to aripiprazole, brexpiprazole has different binding affinities for dopamine and serotonin receptors. Compared...
Approved
Investigational
Matched Description: … [A182186] Currently approved for the treatment of depression, schizophrenia, and agitation associated …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Trimethoprim

Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with sulfamethoxazole due to their...
Approved
Vet approved
Matched Description: … that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of ... tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately ... complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of …
Matched Mixtures name: … TRIMETROPINA SULFA F MK …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Tegaserod

Novartis' brand name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of irritable bowel syndrome with constipation (IBS-C).[L5918,F4229] It was, however, voluntarily withdrawn from widespread use in the US market in 2007 after concerns arose over the possibility that tegaserod could potentially cause...
Approved
Investigational
Withdrawn
Matched Description: … have resulted in the limited reintroduction or 're-approval' of tegaserod for treatment of IBS-C specifically ... in female patients less than 65 years of age and whom are considered to be at a lower risk of a cardiovascular ... name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Lofexidine

Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment...
Approved
Investigational
Matched Description: … non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of ... [T210] Lofexidine was then repurposed for the treatment of opioid withdrawal, as it was seen to be more ... antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Fluocortolone

Fluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.
Approved
Withdrawn
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Sildenafil

In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to...
Approved
Investigational
Matched Description: … In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic ... The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth ... Nevertheless, it is because of this mechanism that sildenafil is also indicated for treating pulmonary …
Matched Categories: … combinations of sulfonamides …

Bupropion

Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake...
Approved
Matched Description: … [A178825,A1966,A16508] A Cochrane Review of meta-analyses of available treatment modalities for smoking ... rate of hypothalamic pro-opiomelanocortin (POMC) neurons and blockade of opioid receptor-mediated POMC ... the brain involved in the regulation of food intake. …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Vortioxetine

Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake...
Approved
Investigational
Matched Description: … of these receptors appear to be involved in the antidepressant effects of SRIs. ... the serotonin transporter, as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an ... antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sodium fluoride

Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as Fluoride ion F-18. Sodium fluoride's benefits on dental health were first observed in the 1930s, when individuals in communities with fluoridated...
Approved
Matched Description: … The use of fluoride in dental practice began in the 1940s. ... Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications ... control dental caries is safe when used correctly and is highly effective in reducing the prevalence of …
Matched Products: … POP Hint Of Mint …

Phenobarbital

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Approved
Investigational
Matched Categories: … combinations of barbiturates ... Metabolic Side Effects of Drugs and Substances …

Tenofovir alafenamide

Tenofovir alafenamide is a novel tenofovir prodrug developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal...
Approved
Matched Description: … [A178060] Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Eletriptan

Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches.
Approved
Investigational
Matched Description: … Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sirolimus

Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor...
Approved
Investigational
Matched Description: … [A13448] Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR ... the Vai Atari region of Rapa Nui (Easter Island). ... lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of …
Matched Categories: … Mammalian target of rapamycin (mTOR) kinase inhibitors …
Displaying drugs 201 - 225 of 8049 in total