Delta-type opioid receptor

Details

Name
Delta-type opioid receptor
Synonyms
  • D-OR-1
  • OPRD
Gene Name
OPRD1
Organism
Human
Amino acid sequence
>lcl|BSEQ0010290|Delta-type opioid receptor
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
Number of residues
372
Molecular Weight
40368.235
Theoretical pI
9.17
GO Classification
Functions
opioid receptor activity / enkephalin receptor activity / neuropeptide binding
Processes
negative regulation of gene expression / positive regulation of CREB transcription factor activity / G-protein coupled receptor signaling pathway / regulation of sensory perception of pain / protein import into nucleus, translocation / phospholipase C-activating G-protein coupled receptor signaling pathway / cellular response to growth factor stimulus / immune response / adult locomotory behavior / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / neuropeptide signaling pathway / adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway / synaptic transmission / regulation of calcium ion transport / cellular response to toxic substance / eating behavior / cellular response to hypoxia / negative regulation of protein oligomerization / positive regulation of peptidyl-serine phosphorylation / regulation of mitochondrial membrane potential / opioid receptor signaling pathway
Components
cytoplasm / postsynaptic membrane / membrane raft / plasma membrane / neuron projection / dendrite membrane / vesicle / intrinsic component of plasma membrane / integral component of plasma membrane / axon terminus
General Function
Opioid receptor activity
Specific Function
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
Pfam Domain Function
Transmembrane Regions
48-75 86-110 123-144 164-186 207-238 262-284 300-321
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010291|Delta-type opioid receptor (OPRD1)
ATGGAACCGGCCCCCTCCGCCGGCGCCGAGCTGCAGCCCCCGCTCTTCGCCAACGCCTCG
GACGCCTACCCTAGCGCCTGCCCCAGCGCTGGCGCCAATGCGTCGGGGCCGCCAGGCGCG
CGGAGCGCCTCGTCCCTCGCCCTGGCAATCGCCATCACCGCGCTCTACTCGGCCGTGTGC
GCCGTGGGGCTGCTGGGCAACGTGCTTGTCATGTTCGGCATCGTCCGGTACACTAAGATG
AAGACGGCCACCAACATCTACATCTTCAACCTGGCCTTAGCCGATGCGCTGGCCACCAGC
ACGCTGCCTTTCCAGAGTGCCAAGTACCTGATGGAGACGTGGCCCTTCGGCGAGCTGCTC
TGCAAGGCTGTGCTCTCCATCGACTACTACAATATGTTCACCAGCATCTTCACGCTCACC
ATGATGAGTGTTGACCGCTACATCGCTGTCTGCCACCCTGTCAAGGCCCTGGACTTCCGC
ACGCCTGCCAAGGCCAAGCTGATCAACATCTGTATCTGGGTCCTGGCCTCAGGCGTTGGC
GTGCCCATCATGGTCATGGCTGTGACCCGTCCCCGGGACGGGGCAGTGGTGTGCATGCTC
CAGTTCCCCAGCCCCAGCTGGTACTGGGACACGGTGACCAAGATCTGCGTGTTCCTCTTC
GCCTTCGTGGTGCCCATCCTCATCATCACCGTGTGCTATGGCCTCATGCTGCTGCGCCTG
CGCAGTGTGCGCCTGCTGTCGGGCTCCAAGGAGAAGGACCGCAGCCTGCGGCGCATCACG
CGCATGGTGCTGGTGGTTGTGGGCGCCTTCGTGGTGTGTTGGGCGCCCATCCACATCTTC
GTCATCGTCTGGACGCTGGTGGACATCGACCGGCGCGACCCGCTGGTGGTGGCTGCGCTG
CACCTGTGCATCGCGCTGGGCTACGCCAATAGCAGCCTCAACCCCGTGCTCTACGCTTTC
CTCGACGAGAACTTCAAGCGCTGCTTCCGCCAGCTCTGCCGCAAGCCCTGCGGCCGCCCA
GACCCCAGCAGCTTCAGCCGCGCCCGCGAAGCCACGGCCCGCGAGCGTGTCACCGCCTGC
ACCCCGTCCGATGGTCCCGGCGGTGGCGCTGCCGCCTGA
Chromosome Location
1
Locus
1p36.1-p34.3
External Identifiers
ResourceLink
UniProtKB IDP41143
UniProtKB Entry NameOPRD_HUMAN
GenBank Protein ID27545517
GenBank Gene IDU07882
GenAtlas IDOPRD1
HGNC IDHGNC:8153
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00318Codeineapproved, illicityesagonistDetails
DB00327Hydromorphoneapproved, illicityespartial agonistDetails
DB00647Dextropropoxypheneapproved, illicit, investigational, withdrawnyesagonistDetails
DB00844NalbuphineapprovedyesantagonistDetails
DB00956Hydrocodoneapproved, illicit, investigationalyesagonistDetails
DB00295Morphineapproved, investigationalyesagonistDetails
DB00611Butorphanolapproved, illicit, vet_approvedyesagonistDetails
DB00813Fentanylapproved, illicit, investigational, vet_approvedyesagonistDetails
DB01183Naloxoneapproved, vet_approvedyesantagonistDetails
DB01497Etorphineillicit, vet_approvedyesagonistDetails
DB01548Diprenorphineillicit, vet_approvedyesantagonistDetails
DB014393-Methylthiofentanylexperimental, illicityesagonistDetails
DB01444Dimethylthiambuteneexperimental, illicitunknownagonistDetails
DB00836LoperamideapprovedyesagonistDetails
DB00704Naltrexoneapproved, investigational, vet_approvedyesantagonistDetails
DB015713-MethylfentanylillicityesagonistDetails
DB05050ADL5859investigationalunknownDetails
DB00497Oxycodoneapproved, illicit, investigationalyesagonistDetails
DB06204TapentadolapprovedunknownDetails
DB01452Heroinapproved, illicit, investigationalunknownagonistDetails
DB00193Tramadolapproved, investigationalnoagonistDetails
DB00333MethadoneapprovedyesagonistDetails
DB00708Sufentanilapproved, investigationalunknownagonistDetails
DB01535Carfentanilillicit, investigational, vet_approvedyesagonistDetails
DB01192Oxymorphoneapproved, investigational, vet_approvedunknownantagonistDetails
DB00321AmitriptylineapprovedunknownagonistDetails
DB01081Diphenoxylateapproved, illicitunknownagonistDetails
DB00854LevorphanolapprovedunknownagonistDetails
DB01565Dihydromorphineexperimental, illicitunknownagonistDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvedunknownantagonistDetails
DB06274Alvimopanapproved, investigationalunknownantagonistDetails
DB00899RemifentanilapprovedunknownagonistDetails
DB06738Ketobemidoneapproved, investigationalyesagonistDetails
DB00514DextromethorphanapprovedunknownagonistDetails
DB01221Ketamineapproved, vet_approvedunknownbinderDetails
DB09272Eluxadolineapproved, investigationalyesantagonistDetails
DB11691Naldemedineapproved, investigationalyesantagonistDetails
DB06230Nalmefeneapproved, investigational, withdrawnyesantagonistDetails
DB09061Cannabidiolapproved, investigationalunknownDetails
DB09209Pholcodineapproved, illicitunknownantagonistDetails
DB11130Opiumapproved, illicityesagonistDetails
DB14011Nabiximolsapproved, investigationalunknownDetails
DB14009Medical Cannabisexperimental, investigationalunknownDetails
DB14146LoxicodegolinvestigationalunknownagonistDetails