Identification

Name
Dextropropoxyphene
Accession Number
DB00647  (APRD00548)
Type
Small Molecule
Groups
Approved, Illicit, Investigational, Withdrawn
Description

Dextropropoxyphene is an analgesic in the opioid category, patented (1955) and manufactured by Eli Lilly and Company. It is intended to treat mild pain and also has antitussive and local anaesthetic effects. The drug has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias. An estimated 10 million patients have used these products.

The drug is often referred to as the general form, "propoxyphene", however only the dextro-isomer (dextropropoxyphene) has any analgesic effect. The levo-isomer appears to exhibit a very limited antitussive effect.

Structure
Thumb
Synonyms
  • d-Propoxyphene
  • Destropropossifene
  • Dextropropoxifeno
  • Dextropropoxyphen
  • Dextropropoxyphène
  • Dextropropoxyphenum
  • Propoxyphene
External IDs
IDS-ND-004(SECT.2) / J5.928E / L 16298 / SK 65 / SK-65
Product Ingredients
IngredientUNIICASInChI Key
Dextropropoxyphene hydrochlorideCB2TL9PS0T1639-60-7QMQBBUPJKANITL-MYXGOWFTSA-N
Dextropropoxyphene napsylate38M219L1OJ26570-10-5GBKONKCASNNUQD-VGHSCWAPSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
642 TabTablet65 mgOralPendopharm Division Of De Pharmascience Inc1968-12-312010-11-25Canada
Darvon-NCapsule100 mgOralPaladin Labs Inc1973-12-312010-12-23Canada
Darvon-NTablet, film coated100 mg/1OralStat Rx USA2009-09-252018-02-08Us
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Novo-propoxyn Cap 65mgCapsule65 mgOralNovopharm Limited1970-12-312005-08-10Canada
PropoxypheneCapsule65 mg/1OralStat Rx USA2009-10-272017-11-04Us
Propoxyphene HydrochlorideCapsule65 mg/1OralHeritage2009-05-012017-11-04Us
Propoxyphene HydrochlorideCapsule65 mg/1Oralbryant ranch prepack2009-12-232016-12-23Us
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
692 TabDextropropoxyphene hydrochloride (65 mg) + Acetylsalicylic acid (375 mg) + Caffeine (30 mg)TabletOralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1986-02-131998-04-21Canada
692 TabletDextropropoxyphene hydrochloride (65 mg) + Acetylsalicylic acid (375 mg) + Caffeine (30 mg)TabletOralLioh Inc.1998-09-012006-08-25Canada
Darvon N Compound Pulvule 405Dextropropoxyphene napsylate (100 mg) + Acetylsalicylic acid (375 mg) + Caffeine (30 mg)CapsuleOralEli Lilly & Co. Ltd.1973-12-311999-08-11Canada
Novo-propoxyn Compound CapDextropropoxyphene hydrochloride (65 mg) + Acetylsalicylic acid (375 mg) + Caffeine (30 mg)CapsuleOralNovopharm Limited1973-12-312005-08-10Canada
Propoxyphene and AcetaminophenDextropropoxyphene napsylate (100 mg/1) + Acetaminophen (650 mg/1)Tablet, film coatedOralAltura Pharmaceuticals, Inc.2010-01-012017-05-09Us
Propoxyphene and AcetaminophenDextropropoxyphene napsylate (100 mg/1) + Acetaminophen (650 mg/1)Tablet, film coatedOralKeltman Pharmaceuticals Inc.2009-03-012017-11-02Us
Propoxyphene Hydrochloride and AcetaminophenDextropropoxyphene hydrochloride (65 mg/1) + Acetaminophen (650 mg/1)Tablet, film coatedOralMylan Pharmaceuticals2009-11-302016-11-29Us
Propoxyphene Napsylate and AcetaminophenDextropropoxyphene napsylate (100 mg/1) + Acetaminophen (650 mg/1)Tablet, film coatedOralLake Erie Medical Dba Quality Care Produts Llc2011-01-252016-12-16Us
Propoxyphene Napsylate and AcetaminophenDextropropoxyphene napsylate (100 mg/1) + Acetaminophen (650 mg/1)Tablet, film coatedOralRed Pharm Drug, Inc.2009-11-252017-02-14Us
Propoxyphene Napsylate and AcetaminophenDextropropoxyphene napsylate (100 mg/1) + Acetaminophen (650 mg/1)Tablet, film coatedOralApotheca, Inc.2009-01-012017-11-04Us
International/Other Brands
Abalgin (DLF) / Dacoton (Standard) / Darvon (Eli Lilly) / Deprancol (Parke Davis) / Depronal (Pfizer) / Dolene / Doloxene (Aspen Pharmacare)
Categories
UNII
S2F83W92TK
CAS number
469-62-5
Weight
Average: 339.4712
Monoisotopic: 339.219829177
Chemical Formula
C22H29NO2
InChI Key
XLMALTXPSGQGBX-GCJKJVERSA-N
InChI
InChI=1S/C22H29NO2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19/h6-15,18H,5,16-17H2,1-4H3/t18-,22+/m1/s1
IUPAC Name
(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl propanoate
SMILES
CCC(=O)O[C@@](CC1=CC=CC=C1)([C@H](C)CN(C)C)C1=CC=CC=C1

Pharmacology

Indication

For the relief of mild to moderate pain

Associated Conditions
Pharmacodynamics

Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. Its general pharmacologic properties are those of the opiates as a group. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli. Propoxyphene possesses little to no antitussive activity and no antipyretic action.

Mechanism of action

Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

TargetActionsOrganism
AMu-type opioid receptor
agonist
Human
ADelta-type opioid receptor
agonist
Human
AKappa-type opioid receptor
antagonist
Human
ULiver carboxylesterase 1Not AvailableHuman
Absorption
Not Available
Volume of distribution
  • 16 L/kg
Protein binding
Not Available
Metabolism

Hepatic

Route of elimination

The major route of metabolism is cytochrome CYP3A4 mediated N-demethylation to norpropoxyphene, which is excreted by the kidneys. In 48 hours, approximately 20% to 25% of the administered dose of propoxyphene is excreted via the urine, most of which is free or conjugated norpropoxyphene.

Half life

6-12 hours

Clearance
  • 2.6 L/min
Toxicity

Coma, respiratory depression, circulatory collapse, and pulmonary edema. Seizures occur more frequently in patients with propoxyphene intoxication than in those with opiate intoxication. LD50=230mg/kg (orally in rat, Emerson)

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Propoxyphene Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Dextropropoxyphene.Experimental, Illicit
2,5-Dimethoxy-4-ethylthioamphetamine2,5-Dimethoxy-4-ethylthioamphetamine may increase the analgesic activities of Dextropropoxyphene.Experimental
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Dextropropoxyphene.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Dextropropoxyphene.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with 7-Nitroindazole.Experimental
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Aceprometazine.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Acetazolamide.Approved, Vet Approved
Acetyl sulfisoxazoleThe metabolism of Dextropropoxyphene can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Dextropropoxyphene.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Agomelatine.Approved, Investigational
AlaproclateDextropropoxyphene may increase the serotonergic activities of Alaproclate.Experimental
AlcuroniumThe risk or severity of adverse effects can be increased when Alcuronium is combined with Dextropropoxyphene.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dextropropoxyphene.Approved, Illicit
AlimemazineAlimemazine may increase the hypotensive activities of Dextropropoxyphene.Approved, Vet Approved
AllopregnanoloneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Alphacetylmethadol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dextropropoxyphene.Approved, Illicit, Investigational
AlvimopanThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Alvimopan.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Amiloride.Approved
AmiodaroneThe metabolism of Dextropropoxyphene can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Dextropropoxyphene.Approved
Ammonium chlorideAmmonium chloride may increase the excretion rate of Dextropropoxyphene which could result in a lower serum level and potentially a reduction in efficacy.Approved, Investigational, Vet Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Dextropropoxyphene.Approved, Illicit
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Dextropropoxyphene.Approved, Investigational
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Dextropropoxyphene.Approved
AmperozideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Amperozide.Experimental
AmphetamineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Amphetamine.Approved, Illicit, Investigational
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Dextropropoxyphene.Approved
ApalutamideThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Apalutamide.Approved, Investigational
AprepitantThe serum concentration of Dextropropoxyphene can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Dextropropoxyphene.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Dextropropoxyphene.Approved
AsunaprevirThe serum concentration of Asunaprevir can be decreased when it is combined with Dextropropoxyphene.Approved, Investigational, Withdrawn
AtazanavirThe metabolism of Dextropropoxyphene can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Dextropropoxyphene can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Atorvastatin.Approved
AtracuriumThe risk or severity of adverse effects can be increased when Atracurium is combined with Dextropropoxyphene.Approved, Experimental, Investigational
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Dextropropoxyphene.Approved
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Dextropropoxyphene.Approved, Vet Approved
AzaperoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Azaperone.Investigational, Vet Approved
AzelastineDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzosemideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Azosemide.Investigational
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Dextropropoxyphene.Approved
BarbitalThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Barbital.Illicit
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Dextropropoxyphene.Withdrawn
BendroflumethiazideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Bendroflumethiazide.Approved
BenmoxinThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Benmoxin.Withdrawn
BenperidolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Benperidol.Approved, Investigational
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Dextropropoxyphene.Approved
BenzocaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Benzocaine.Approved, Investigational
BenzphetamineBenzphetamine may increase the analgesic activities of Dextropropoxyphene.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Benzyl alcohol.Approved
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Dextropropoxyphene.Approved, Investigational
BL-1020BL-1020 may increase the hypotensive activities of Dextropropoxyphene.Investigational
BoceprevirThe metabolism of Dextropropoxyphene can be decreased when combined with Boceprevir.Approved, Withdrawn
BornaprineThe risk or severity of adverse effects can be increased when Bornaprine is combined with Dextropropoxyphene.Experimental
BortezomibThe metabolism of Dextropropoxyphene can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Dextropropoxyphene.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Brexpiprazole is combined with Dextropropoxyphene.Approved, Investigational
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved
BrofaromineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Brofaromine.Experimental
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Dextropropoxyphene.Approved, Illicit, Investigational
BromisovalThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Bromisoval.Experimental
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Dextropropoxyphene.Approved, Investigational
BromotheophyllineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Bromotheophylline.Approved
BromperidolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Bromperidol.Approved, Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Dextropropoxyphene.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Brotizolam.Approved, Investigational, Withdrawn
BumetanideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Bumetanide.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dextropropoxyphene.Approved, Investigational
BuprenorphineDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Dextropropoxyphene.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Dextropropoxyphene.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Dextropropoxyphene.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Butamben.Approved, Withdrawn
ButethalThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Butethal.Approved, Illicit
ButorphanolButorphanol may decrease the analgesic activities of Dextropropoxyphene.Approved, Illicit, Vet Approved
ButylscopolamineThe risk or severity of adverse effects can be increased when Butylscopolamine is combined with Dextropropoxyphene.Approved, Investigational, Vet Approved
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Dextropropoxyphene.Approved
CanertinibThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Canertinib.Investigational
Canrenoic acidThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Canrenoic acid.Approved, Withdrawn
CanrenoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Canrenone.Investigational
CarbamazepineThe metabolism of Dextropropoxyphene can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Dextropropoxyphene.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Carfentanil.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Dextropropoxyphene.Approved
CaroxazoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Caroxazone.Withdrawn
CeritinibThe serum concentration of Dextropropoxyphene can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Dextropropoxyphene.Approved, Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Dextropropoxyphene.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chloral hydrate.Approved, Illicit, Investigational, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dextropropoxyphene.Approved, Illicit, Investigational
ChlormezanoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chlormezanone.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chloroprocaine.Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Dextropropoxyphene.Approved
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Dextropropoxyphene.Withdrawn
ChlorphentermineChlorphentermine may increase the analgesic activities of Dextropropoxyphene.Illicit, Withdrawn
ChlorproethazineChlorproethazine may increase the hypotensive activities of Dextropropoxyphene.Experimental
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Dextropropoxyphene.Approved, Investigational, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chlorprothixene.Approved, Investigational, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chlorthalidone.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Dextropropoxyphene.Approved
CicletanineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Cicletanine.Investigational
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Dextropropoxyphene.Approved, Vet Approved
CitalopramDextropropoxyphene may increase the serotonergic activities of Citalopram.Approved
ClarithromycinThe metabolism of Dextropropoxyphene can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Dextropropoxyphene can be decreased when combined with Clemastine.Approved, Investigational
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Dextropropoxyphene.Approved
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Dextropropoxyphene.Approved, Illicit
ClofenamideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Clofenamide.Experimental
clomethiazoleThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Dextropropoxyphene.Approved, Investigational, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Clonazepam is combined with Dextropropoxyphene.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Dextropropoxyphene.Approved
ClopamideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Clopamide.Experimental
ClopenthixolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Dextropropoxyphene.Approved, Illicit
ClorexoloneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Clorexolone.Experimental
ClothiapineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Clothiapine.Experimental
ClotrimazoleThe metabolism of Dextropropoxyphene can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Dextropropoxyphene.Approved
CobicistatThe metabolism of Dextropropoxyphene can be decreased when combined with Cobicistat.Approved
CocaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Dextropropoxyphene.Approved, Illicit
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Dextropropoxyphene.Approved, Investigational
CrizotinibThe metabolism of Dextropropoxyphene can be decreased when combined with Crizotinib.Approved
CurcuminThe metabolism of Dextropropoxyphene can be decreased when combined with Curcumin.Approved, Investigational
CyclizineThe risk or severity of adverse effects can be increased when Cyclizine is combined with Dextropropoxyphene.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dextropropoxyphene.Approved
CyclopenthiazideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Cyclopenthiazide.Experimental
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Dextropropoxyphene.Approved
CyclopropaneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Cyclopropane.Experimental
CyclosporineThe metabolism of Dextropropoxyphene can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyclothiazideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Cyclothiazide.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Dextropropoxyphene.Approved
DabrafenibThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Dabrafenib.Approved, Investigational
DantroleneThe risk or severity of adverse effects can be increased when Dantrolene is combined with Dextropropoxyphene.Approved, Investigational
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Dextropropoxyphene.Approved
DapoxetineDextropropoxyphene may increase the serotonergic activities of Dapoxetine.Investigational
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Dextropropoxyphene.Approved, Investigational
DarunavirThe metabolism of Dextropropoxyphene can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Dextropropoxyphene can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Dextropropoxyphene can be decreased when combined with Delavirdine.Approved
DeramciclaneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Dextropropoxyphene.Approved
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Dextropropoxyphene.Approved, Investigational
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Dextropropoxyphene.Approved, Investigational
DesmopressinThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Desmopressin.Approved
DesvenlafaxineDextropropoxyphene may increase the serotonergic activities of Desvenlafaxine.Approved, Investigational
DetomidineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Dextropropoxyphene.Approved
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Dextropropoxyphene.Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Dextropropoxyphene.Approved, Vet Approved
DextroamphetamineDextroamphetamine may increase the analgesic activities of Dextropropoxyphene.Approved, Illicit
DextromoramideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Dextromoramide.Experimental, Illicit
DezocineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Dezocine.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Dextropropoxyphene.Approved, Illicit, Investigational, Vet Approved
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Dextropropoxyphene.Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Diethyl ether.Experimental
DiethylpropionDiethylpropion may increase the analgesic activities of Dextropropoxyphene.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Difenoxin is combined with Dextropropoxyphene.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Dextropropoxyphene.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Dextropropoxyphene.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Dextropropoxyphene.Approved, Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Dextropropoxyphene.Experimental
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Dextropropoxyphene.Approved, Investigational
DihydroetorphineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Dihydromorphine.Experimental, Illicit
DiltiazemThe metabolism of Dextropropoxyphene can be decreased when combined with Diltiazem.Approved, Investigational
DimenhydrinateThe risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Dextropropoxyphene.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dextropropoxyphene.Approved, Investigational
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Dextropropoxyphene.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Dextropropoxyphene.Approved, Investigational
DoxycyclineThe metabolism of Dextropropoxyphene can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with DPDPE.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved, Illicit
DronedaroneThe metabolism of Dextropropoxyphene can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved, Vet Approved
DrospirenoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Drospirenone.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Drotebanol.Experimental, Illicit
DuloxetineDextropropoxyphene may increase the serotonergic activities of Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Dextropropoxyphene.Approved
EcgonineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ecgonine.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Dextropropoxyphene.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Efonidipine.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Eltanolone.Investigational
EluxadolineDextropropoxyphene may increase the constipating activities of Eluxadoline.Approved, Investigational
EmeproniumThe risk or severity of adverse effects can be increased when Emepronium is combined with Dextropropoxyphene.Experimental
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Dextropropoxyphene.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Dextropropoxyphene.Approved, Investigational
EnzalutamideThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Enzalutamide.Approved
EpitizideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Epitizide.Experimental
EplerenoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Eplerenone.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Dextropropoxyphene.Approved
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Dextropropoxyphene.Approved
ErythromycinThe metabolism of Dextropropoxyphene can be decreased when combined with Erythromycin.Approved, Investigational, Vet Approved
EscitalopramDextropropoxyphene may increase the serotonergic activities of Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Dextropropoxyphene.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Dextropropoxyphene.Approved, Investigational
Etacrynic acidThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Etacrynic acid.Approved, Investigational
EtanautineThe risk or severity of adverse effects can be increased when Etanautine is combined with Dextropropoxyphene.Experimental
EthanolDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Dextropropoxyphene.Approved, Illicit, Withdrawn
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Dextropropoxyphene.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Dextropropoxyphene.Approved
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Dextropropoxyphene.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ethoxzolamide.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ethyl carbamate.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ethyl chloride.Approved, Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Etifoxine.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Dextropropoxyphene.Approved
EtoperidoneDextropropoxyphene may increase the serotonergic activities of Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Etorphine.Illicit, Vet Approved
EtybenzatropineThe risk or severity of adverse effects can be increased when Etybenzatropine is combined with Dextropropoxyphene.Experimental
EzogabineThe risk or severity of adverse effects can be increased when Ezogabine is combined with Dextropropoxyphene.Approved, Investigational
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Dextropropoxyphene.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Fencamfamine.Approved, Illicit, Withdrawn
FenquizoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Fenquizone.Experimental
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Dextropropoxyphene.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Dextropropoxyphene.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Dextropropoxyphene.Approved, Investigational
FlavoxateThe risk or severity of adverse effects can be increased when Flavoxate is combined with Dextropropoxyphene.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Flibanserin is combined with Dextropropoxyphene.Approved, Investigational
FluanisoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Fluanisone.Experimental
FluconazoleThe metabolism of Dextropropoxyphene can be decreased when combined with Fluconazole.Approved, Investigational
FludiazepamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Flunarizine is combined with Dextropropoxyphene.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Flunitrazepam.Approved, Illicit
FluoxetineDextropropoxyphene may increase the serotonergic activities of Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Dextropropoxyphene.Approved, Investigational, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Dextropropoxyphene.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Dextropropoxyphene.Approved, Illicit, Investigational
FluspirileneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Fluspirilene.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Dextropropoxyphene.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Dextropropoxyphene.Approved
FluvoxamineThe metabolism of Dextropropoxyphene can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Dextropropoxyphene can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Dextropropoxyphene can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Dextropropoxyphene can be increased when combined with Fosphenytoin.Approved, Investigational
FospropofolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Fospropofol.Approved, Illicit, Investigational
FurazolidoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Furazolidone.Approved, Investigational, Vet Approved
FurosemideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Furosemide.Approved, Vet Approved
Fusidic AcidThe serum concentration of Dextropropoxyphene can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Dextropropoxyphene.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Gabapentin Enacarbil is combined with Dextropropoxyphene.Approved, Investigational
GallamineThe risk or severity of adverse effects can be increased when Gallamine is combined with Dextropropoxyphene.Experimental
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Dextropropoxyphene.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Dextropropoxyphene.Approved, Illicit, Investigational
GepefrineGepefrine may increase the analgesic activities of Dextropropoxyphene.Experimental
GepironeThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Glutethimide.Approved, Illicit
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Dextropropoxyphene.Approved, Investigational, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Guanfacine is combined with Dextropropoxyphene.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Halazepam.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Dextropropoxyphene.Approved
HalothaneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Halothane.Approved, Vet Approved
HarmalineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Harmaline.Experimental
HeroinThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Heroin.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Hexobarbital.Approved
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Dextropropoxyphene.Approved
HydracarbazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Hydracarbazine.Experimental
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Hydroflumethiazide.Approved, Investigational
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Dextropropoxyphene.Approved, Illicit
HydroxyamphetamineHydroxyamphetamine may increase the analgesic activities of Dextropropoxyphene.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Dextropropoxyphene.Approved
IbopamineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ibopamine.Experimental
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Dextropropoxyphene.Approved
IdelalisibThe metabolism of Dextropropoxyphene can be decreased when combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Iloperidone is combined with Dextropropoxyphene.Approved
ImatinibThe metabolism of Dextropropoxyphene can be decreased when combined with Imatinib.Approved
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Dextropropoxyphene.Approved
IndalpineDextropropoxyphene may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Indapamide.Approved
IndinavirThe metabolism of Dextropropoxyphene can be decreased when combined with Indinavir.Approved
IndiplonThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Indiplon.Investigational
Iofetamine I-123Iofetamine I-123 may increase the analgesic activities of Dextropropoxyphene.Approved
IpratropiumThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dextropropoxyphene.Approved
IproclozideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Iproclozide.Withdrawn
IproniazidThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Iproniazid.Withdrawn
IsavuconazoleThe serum concentration of Dextropropoxyphene can be increased when it is combined with Isavuconazole.Approved, Investigational
IsavuconazoniumThe metabolism of Dextropropoxyphene can be decreased when combined with Isavuconazonium.Approved, Investigational
IsocarboxazidThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Isocarboxazid.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Dextropropoxyphene.Approved, Vet Approved
IsosorbideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Isosorbide.Approved, Investigational
IsradipineThe metabolism of Dextropropoxyphene can be decreased when combined with Isradipine.Approved, Investigational
ItraconazoleThe metabolism of Dextropropoxyphene can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Dextropropoxyphene can be increased when it is combined with Ivacaftor.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Dextropropoxyphene.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ketobemidone.Approved, Investigational
KetoconazoleThe metabolism of Dextropropoxyphene can be decreased when combined with Ketoconazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Dextropropoxyphene.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Dextropropoxyphene.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Levobupivacaine.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Levocabastine.Approved, Investigational
LevocetirizineThe risk or severity of adverse effects can be increased when Levocetirizine is combined with Dextropropoxyphene.Approved
LevodopaThe risk or severity of adverse effects can be increased when Levodopa is combined with Dextropropoxyphene.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Levomethadyl Acetate.Approved, Investigational
LevomilnacipranDextropropoxyphene may increase the serotonergic activities of Levomilnacipran.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Dextropropoxyphene.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dextropropoxyphene.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Dextropropoxyphene.Approved, Investigational
LisurideThe risk or severity of adverse effects can be increased when Lisuride is combined with Dextropropoxyphene.Approved, Investigational
Lithium cationThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Lithium.Experimental
LofentanilThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Lofentanil.Illicit
LofexidineThe therapeutic efficacy of Dextropropoxyphene can be increased when used in combination with Lofexidine.Approved, Investigational
LopinavirThe metabolism of Dextropropoxyphene can be decreased when combined with Lopinavir.Approved
LoprazolamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Dextropropoxyphene.Approved, Investigational
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dextropropoxyphene.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Lormetazepam.Approved
LorpiprazoleThe serum concentration of Dextropropoxyphene can be increased when it is combined with Lorpiprazole.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Dextropropoxyphene.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Dextropropoxyphene.Approved
LuliconazoleThe serum concentration of Dextropropoxyphene can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Dextropropoxyphene can be increased when combined with Lumacaftor.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Dextropropoxyphene.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Dextropropoxyphene.Illicit, Investigational, Withdrawn
Magnesium sulfateThe therapeutic efficacy of Dextropropoxyphene can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
MannitolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Mannitol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Dextropropoxyphene.Approved, Investigational
MazaticolThe risk or severity of adverse effects can be increased when Mazaticol is combined with Dextropropoxyphene.Experimental
MebanazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Mebanazine.Withdrawn
MebicarThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Mebicar.Experimental
MebutizideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Mebutizide.Experimental
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Dextropropoxyphene.Approved, Investigational
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dextropropoxyphene.Approved
MedazepamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Medetomidine.Vet Approved
MefrusideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Mefruside.Experimental
MelatoninThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Melperone.Approved, Investigational
MephedroneMephedrone may increase the analgesic activities of Dextropropoxyphene.Investigational
MephentermineMephentermine may increase the analgesic activities of Dextropropoxyphene.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Dextropropoxyphene.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Meptazinol.Experimental
MersalylThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Mersalyl.Approved
MesoridazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Mesoridazine.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Dextropropoxyphene.Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Dextropropoxyphene.Experimental
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Dextropropoxyphene.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methadyl Acetate.Approved, Illicit
MethamphetamineMethamphetamine may increase the analgesic activities of Dextropropoxyphene.Approved, Illicit
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Dextropropoxyphene.Approved, Investigational
MethapyrileneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methaqualone.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methazolamide.Approved
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Dextropropoxyphene.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Dextropropoxyphene.Approved
MethotrimeprazineDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved, Investigational
MethoxyfluraneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methoxyflurane.Approved, Investigational, Vet Approved
MethoxyphenamineMethoxyphenamine may increase the analgesic activities of Dextropropoxyphene.Experimental
MethscopolamineThe risk or severity of adverse effects can be increased when Methscopolamine is combined with Dextropropoxyphene.Approved
MethsuximideThe risk or severity of adverse effects can be increased when Methsuximide is combined with Dextropropoxyphene.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methyclothiazide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methylecgonine.Experimental
Methylene blueThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methylene blue.Approved, Investigational
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Dextropropoxyphene.Approved
MethylnaltrexoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methylnaltrexone.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methylphenobarbital.Approved
Methylscopolamine bromideThe risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with Dextropropoxyphene.Approved
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Dextropropoxyphene.Approved
MeticraneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Meticrane.Experimental
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Dextropropoxyphene.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Metolazone.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Dextropropoxyphene.Approved, Investigational
MetyrosineDextropropoxyphene may increase the sedative activities of Metyrosine.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Dextropropoxyphene.Experimental
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Dextropropoxyphene.Approved, Illicit
MidomafetamineMidomafetamine may increase the analgesic activities of Dextropropoxyphene.Experimental, Illicit, Investigational
MifepristoneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranDextropropoxyphene may increase the serotonergic activities of Milnacipran.Approved, Investigational
MinaprineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Minaprine.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved, Investigational
MirtazapineDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Mitotane.Approved
MMDAMMDA may increase the analgesic activities of Dextropropoxyphene.Experimental, Illicit
MoclobemideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Moclobemide.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Molindone.Approved
MoricizineMoricizine may increase the hypotensive activities of Dextropropoxyphene.Approved, Investigational, Withdrawn
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Dextropropoxyphene.Approved, Investigational
MuzolimineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Muzolimine.Experimental
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved, Investigational
NalbuphineNalbuphine may decrease the analgesic activities of Dextropropoxyphene.Approved
NaloxegolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Naloxegol.Approved
NaltrexoneThe therapeutic efficacy of Dextropropoxyphene can be decreased when used in combination with Naltrexone.Approved, Investigational, Vet Approved
NefazodoneThe metabolism of Dextropropoxyphene can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Dextropropoxyphene can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Dextropropoxyphene can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Dextropropoxyphene can be increased when combined with Nevirapine.Approved
NialamideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Nialamide.Withdrawn
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Dextropropoxyphene.Approved, Investigational
NilotinibThe metabolism of Dextropropoxyphene can be decreased when combined with Nilotinib.Approved, Investigational
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Dextropropoxyphene.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dextropropoxyphene.Approved, Vet Approved
NordazepamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Nordazepam.Approved
NorfluraneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Norflurane.Approved, Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Dextropropoxyphene.Approved
OctamoxinThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Octamoxin.Withdrawn
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Dextropropoxyphene.Approved, Investigational
OlaparibThe metabolism of Dextropropoxyphene can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Dextropropoxyphene.Approved
OndansetronThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Opium.Approved, Illicit
OrphenadrineDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Osanetant.Investigational
OsimertinibThe serum concentration of Dextropropoxyphene can be increased when it is combined with Osimertinib.Approved
OtiloniumThe risk or severity of adverse effects can be increased when Otilonium is combined with Dextropropoxyphene.Experimental, Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Dextropropoxyphene.Approved
OxitropiumThe risk or severity of adverse effects can be increased when Oxitropium is combined with Dextropropoxyphene.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Oxybuprocaine.Approved, Investigational
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Dextropropoxyphene.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dextropropoxyphene.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Dextropropoxyphene.Approved, Investigational, Vet Approved
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Dextropropoxyphene.Approved
PalbociclibThe serum concentration of Dextropropoxyphene can be increased when it is combined with Palbociclib.Approved, Investigational
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Dextropropoxyphene.Approved
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Dextropropoxyphene.Approved
ParaldehydeDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
PargylineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Pargyline.Approved
ParoxetineDextropropoxyphene may increase the serotonergic activities of Paroxetine.Approved, Investigational
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Dextropropoxyphene.Approved
PenfluridolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Penfluridol.Experimental
PentazocinePentazocine may decrease the analgesic activities of Dextropropoxyphene.Approved, Vet Approved
PentobarbitalThe metabolism of Dextropropoxyphene can be increased when combined with Pentobarbital.Approved, Investigational, Vet Approved
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Dextropropoxyphene.Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved
PerazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Perazine.Approved, Investigational
PergolideThe risk or severity of adverse effects can be increased when Pergolide is combined with Dextropropoxyphene.Approved, Investigational, Vet Approved, Withdrawn
PerospironeThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Dextropropoxyphene.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Dextropropoxyphene.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Phenazocine.Experimental
PhenelzineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Phenelzine.Approved
PhenglutarimideThe risk or severity of adverse effects can be increased when Phenglutarimide is combined with Dextropropoxyphene.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Phenibut.Experimental
PheniprazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Pheniprazine.Withdrawn
PhenobarbitalThe metabolism of Dextropropoxyphene can be increased when combined with Phenobarbital.Approved, Investigational
PhenoperidineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Phenoxyethanol.Approved
PhenoxypropazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Phenoxypropazine.Withdrawn
PhenterminePhentermine may increase the analgesic activities of Dextropropoxyphene.Approved, Illicit
PhenytoinThe metabolism of Dextropropoxyphene can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Dextropropoxyphene.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Pipamperone.Approved, Investigational
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Dextropropoxyphene.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Pipotiazine is combined with Dextropropoxyphene.Approved, Investigational
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Dextropropoxyphene.Approved
PiretanideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Piretanide.Approved
PiritramideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Piritramide.Approved, Investigational
PirlindoleThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Pirlindole.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Dextropropoxyphene.Approved
PitolisantThe serum concentration of Pitolisant can be increased when it is combined with Dextropropoxyphene.Approved, Investigational
PivhydrazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Pivhydrazine.Withdrawn
PizotifenThe risk or severity of adverse effects can be increased when Pizotifen is combined with Dextropropoxyphene.Approved
PolythiazideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Polythiazide.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Dextropropoxyphene.Approved
PosaconazoleThe metabolism of Dextropropoxyphene can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
Potassium cationThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Potassium.Approved, Investigational
Potassium CitrateThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Potassium Citrate.Approved, Investigational, Vet Approved
PramipexoleDextropropoxyphene may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Pramocaine.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Dextropropoxyphene.Approved
PrazepamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Prazepam.Approved, Illicit
PregabalinThe therapeutic efficacy of Dextropropoxyphene can be increased when used in combination with Pregabalin.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Prilocaine.Approved
PrimidoneThe metabolism of Dextropropoxyphene can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Procaine.Approved, Investigational, Vet Approved
ProcarbazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Procarbazine.Approved, Investigational
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Dextropropoxyphene.Approved, Vet Approved
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Dextropropoxyphene.Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Dextropropoxyphene.Approved, Vet Approved
PromethazinePromethazine may increase the hypotensive activities of Dextropropoxyphene.Approved, Investigational
PropanididThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Propanidid.Experimental
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Dextropropoxyphene.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Proparacaine.Approved, Vet Approved
PropericiazinePropericiazine may increase the hypotensive activities of Dextropropoxyphene.Approved, Investigational
PropiopromazinePropiopromazine may increase the hypotensive activities of Dextropropoxyphene.Vet Approved
PropiverineThe risk or severity of adverse effects can be increased when Propiverine is combined with Dextropropoxyphene.Approved, Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Dextropropoxyphene.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Dextropropoxyphene.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with PSD502.Investigational
PseudoephedrinePseudoephedrine may increase the analgesic activities of Dextropropoxyphene.Approved
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Dextropropoxyphene.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Dextropropoxyphene.Approved
QuinethazoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Quinethazone.Approved
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Dextropropoxyphene.Approved, Investigational
QuinisocaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Ramelteon is combined with Dextropropoxyphene.Approved, Investigational
RamosetronDextropropoxyphene may increase the constipating activities of Ramosetron.Approved, Investigational
RanolazineThe metabolism of Dextropropoxyphene can be decreased when combined with Ranolazine.Approved, Investigational
RasagilineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Rasagiline.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Dextropropoxyphene.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Dextropropoxyphene.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Dextropropoxyphene.Approved, Investigational
RifabutinThe metabolism of Dextropropoxyphene can be increased when combined with Rifabutin.Approved, Investigational
RifampicinThe metabolism of Dextropropoxyphene can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Dextropropoxyphene can be increased when combined with Rifapentine.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Dextropropoxyphene.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Dextropropoxyphene.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ritanserin.Investigational
RitobegronRitobegron may increase the analgesic activities of Dextropropoxyphene.Investigational
RolofyllineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Rolofylline.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Romifidine.Vet Approved
RopiniroleDextropropoxyphene may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Dextropropoxyphene.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Dextropropoxyphene.Approved
RotigotineDextropropoxyphene may increase the sedative activities of Rotigotine.Approved
RucaparibThe metabolism of Dextropropoxyphene can be decreased when combined with Rucaparib.Approved, Investigational
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Dextropropoxyphene.Approved
SafrazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Safrazine.Withdrawn
SaquinavirThe metabolism of Dextropropoxyphene can be decreased when combined with Saquinavir.Approved, Investigational
SarilumabThe therapeutic efficacy of Dextropropoxyphene can be decreased when used in combination with Sarilumab.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Dextropropoxyphene.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Dextropropoxyphene.Approved, Investigational
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Dextropropoxyphene.Approved, Vet Approved
SelegilineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Selegiline.Approved, Investigational, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Sertindole.Approved, Investigational, Withdrawn
SertralineDextropropoxyphene may increase the serotonergic activities of Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Dextropropoxyphene.Approved, Vet Approved
SildenafilThe metabolism of Dextropropoxyphene can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Dextropropoxyphene can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Dextropropoxyphene.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Dextropropoxyphene.Approved
SpiradolineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Spiradoline.Investigational
SpironolactoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Dextropropoxyphene can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StiripentolThe serum concentration of Dextropropoxyphene can be increased when it is combined with Stiripentol.Approved
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Dextropropoxyphene.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Dextropropoxyphene.Approved, Investigational
SulfisoxazoleThe metabolism of Dextropropoxyphene can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Dextropropoxyphene.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Sultopride.Experimental
SuvorexantDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Tasimelteon is combined with Dextropropoxyphene.Approved, Investigational
TelaprevirThe metabolism of Dextropropoxyphene can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Dextropropoxyphene can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Dextropropoxyphene.Approved, Investigational
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Dextropropoxyphene.Experimental
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Dextropropoxyphene.Approved, Investigational
TetracaineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Tetrodotoxin.Investigational
ThalidomideDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheobromineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Theobromine.Approved, Investigational
ThiamylalThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Thiamylal.Approved, Vet Approved
ThiazinamThiazinam may increase the hypotensive activities of Dextropropoxyphene.Experimental
ThiethylperazineThiethylperazine may increase the hypotensive activities of Dextropropoxyphene.Withdrawn
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Dextropropoxyphene.Approved, Vet Approved
ThioproperazineThioproperazine may increase the hypotensive activities of Dextropropoxyphene.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Dextropropoxyphene.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Dextropropoxyphene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Dextropropoxyphene.Approved, Investigational
TiaprideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Tiapride.Approved, Investigational
TiclopidineThe metabolism of Dextropropoxyphene can be decreased when combined with Ticlopidine.Approved
TicrynafenThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ticrynafen.Withdrawn
TiletamineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Tilidine.Experimental
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Dextropropoxyphene.Approved
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Dextropropoxyphene.Approved, Investigational
TocilizumabThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Dextropropoxyphene.Approved, Withdrawn
ToloxatoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Toloxatone.Approved
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Dextropropoxyphene.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Dextropropoxyphene.Approved
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Dextropropoxyphene.Approved
TorasemideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Torasemide.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Dextropropoxyphene.Approved, Investigational
TranylcypromineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Tranylcypromine.Approved, Investigational
TrazodoneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Trazodone.Approved, Investigational
TriamtereneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Triamterene.Approved
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Dextropropoxyphene.Approved, Investigational
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Tricaine methanesulfonate.Vet Approved
TrichlormethiazideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Trichlormethiazide.Approved, Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Trichloroethylene.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Dextropropoxyphene.Approved, Investigational
TrifluperidolThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Dextropropoxyphene.Approved, Vet Approved
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Dextropropoxyphene.Approved
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Dextropropoxyphene.Approved, Investigational
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Dextropropoxyphene.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Dextropropoxyphene.Approved
TropatepineThe risk or severity of adverse effects can be increased when Tropatepine is combined with Dextropropoxyphene.Experimental
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Dextropropoxyphene.Approved, Investigational
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Dextropropoxyphene.Approved
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Dextropropoxyphene.Approved
UlaritideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Ularitide.Investigational
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Dextropropoxyphene.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Dextropropoxyphene.Approved, Investigational
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Dextropropoxyphene.Approved
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Dextropropoxyphene.Approved
VenlafaxineThe metabolism of Dextropropoxyphene can be decreased when combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Veralipride.Experimental
VerapamilThe metabolism of Dextropropoxyphene can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Vigabatrin is combined with Dextropropoxyphene.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Vinyl ether.Experimental
VoriconazoleThe metabolism of Dextropropoxyphene can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Vortioxetine.Approved, Investigational
XenonThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Xenon.Experimental
XipamideThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Xipamide.Experimental
XylazineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Dextropropoxyphene.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Ziconotide is combined with Dextropropoxyphene.Approved
ZimelidineDextropropoxyphene may increase the serotonergic activities of Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Dextropropoxyphene can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Zolazepam.Vet Approved
ZolpidemDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Zonisamide is combined with Dextropropoxyphene.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Dextropropoxyphene.Approved
ZotepineThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Zotepine.Approved, Investigational, Withdrawn
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Dextropropoxyphene.Approved, Investigational
Food Interactions
  • Take without regard to meals. Avoid alcohol.

References

Synthesis Reference

Carl R. White, "Synthesis and purification of d-propoxyphene hydrochloride." U.S. Patent US4661625, issued April, 1973.

US4661625
General References
  1. Coda BA, Rudy AC, Archer SM, Wermeling DP: Pharmacokinetics and bioavailability of single-dose intranasal hydromorphone hydrochloride in healthy volunteers. Anesth Analg. 2003 Jul;97(1):117-23, table of contents. [PubMed:12818953]
  2. Ulens C, Daenens P, Tytgat J: Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents. Cardiovasc Res. 1999 Dec;44(3):568-78. [PubMed:10690289]
  3. Tyers MB: A classification of opiate receptors that mediate antinociception in animals. Br J Pharmacol. 1980 Jul;69(3):503-12. [PubMed:6249436]
  4. FDA data [Link]
  5. Drug Information [Link]
  6. Drugs.com [Link]
External Links
KEGG Drug
D07809
KEGG Compound
C07406
PubChem Compound
10100
PubChem Substance
46506690
ChemSpider
9696
BindingDB
82269
ChEBI
51173
ChEMBL
CHEMBL1213351
Therapeutic Targets Database
DAP000017
PharmGKB
PA451142
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Propoxyphene
ATC Codes
N02AC54 — Dextropropoxyphene, combinations excl. psycholepticsN02AC04 — DextropropoxypheneN02AC74 — Dextropropoxyphene, combinations with psycholeptics
MSDS
Download (46.1 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedSupportive CarePain / Unspecified Adult Solid Tumor, Protocol Specific1
4TerminatedTreatmentHealthy Volunteers1

Pharmacoeconomics

Manufacturers
  • Xanodyne pharmaceutics inc
  • Heritage pharmaceuticals inc
  • Mk laboratories inc
  • Halsey drug co inc
  • Alra laboratories inc
  • Impax laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Nexgen pharma inc
  • Par pharmaceutical inc
  • Purepac pharmaceutical co
  • Private formulations inc
  • Roxane laboratories inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Valeant pharmaceuticals international
  • Vintage pharmaceuticals inc
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Whiteworth towne paulsen inc
  • Warner chilcott div warner lambert co
  • Aaipharma llc
Packagers
  • AAIPharma Inc.
  • Aidarex Pharmacuticals LLC
  • Altura Pharmaceuticals Inc.
  • Amerisource Health Services Corp.
  • Apotheca Inc.
  • Aristos Pharmaceuticals
  • A-S Medication Solutions LLC
  • Blenheim Pharmacal
  • Bryant Ranch Prepack
  • Cardinal Health
  • Caremark LLC
  • Comprehensive Consultant Services Inc.
  • Corepharma LLC
  • Cornerstone Pharmacy
  • D.M. Graham Laboratories Inc.
  • Direct Dispensing Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • DSM Corp.
  • Golden State Medical Supply Inc.
  • H and H Laboratories
  • H.J. Harkins Co. Inc.
  • Heartland Repack Services LLC
  • Innoviant Pharmacy Inc.
  • Ivax Pharmaceuticals
  • Kaiser Foundation Hospital
  • Keltman Pharmaceuticals Inc.
  • Lake Erie Medical and Surgical Supply
  • Liberty Pharmaceuticals
  • Lilly Del Caribe Inc.
  • Major Pharmaceuticals
  • Mallinckrodt Inc.
  • Mckesson Corp.
  • Medvantx Inc.
  • Mikart Inc.
  • Murfreesboro Pharmaceutical Nursing Supply
  • Mylan
  • Nexgen Pharma Inc.
  • Nucare Pharmaceuticals Inc.
  • Palmetto Pharmaceuticals Inc.
  • Par Pharmaceuticals
  • PCA LLC
  • PD-Rx Pharmaceuticals Inc.
  • Pharmedix
  • Physicians Total Care Inc.
  • Pliva Inc.
  • Preferred Pharmaceuticals Inc.
  • Prepackage Specialists
  • Prepak Systems Inc.
  • Qualitest
  • Ranbaxy Laboratories
  • Rebel Distributors Corp.
  • Redpharm Drug
  • Remedy Repack
  • Resource Optimization and Innovation LLC
  • Sandhills Packaging Inc.
  • Smartscience Laboratories Inc.
  • Southwood Pharmaceuticals
  • St Mary's Medical Park Pharmacy
  • Stat Rx Usa
  • Talbert Medical Management Corp.
  • Teva Pharmaceutical Industries Ltd.
  • UDL Laboratories
  • Va Cmop Dallas
  • Veratex Corp.
  • Vintage Pharmaceuticals Inc.
  • Watson Pharmaceuticals
  • West-Ward Pharmaceuticals
  • Wockhardt Ltd.
  • Xanodyne Pharmaceuticals Inc.
Dosage forms
FormRouteStrength
TabletOral65 mg
TabletOral
CapsuleOral
CapsuleOral100 mg
Tablet, film coatedOral100 mg/1
CapsuleOral65 mg
CapsuleOral65 mg/1
Tablet, film coatedOral
Prices
Unit descriptionCostUnit
Propoxyphene napsylate powder5.33USD g
Darvon-n 100 mg tablet2.16USD tablet
Darvon 65 mg capsule1.71USD capsule
Propoxyphene N-APAP 100-500 mg tablet1.6USD tablet
Darvon 65 mg pulvule1.49USD each
Propoxyphene N-APAP 50-325 mg tablet1.32USD tablet
Propoxyphene-APAP 65-650 mg tablet0.57USD tablet
Propoxyphene N-APAP 100-650 mg tablet0.47USD tablet
Propoxyphene hcl 65 mg capsule0.43USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)75.5 °CPhysProp
water solubility3.32 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP4.18HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.00419 mg/mLALOGPS
logP4.06ALOGPS
logP4.9ChemAxon
logS-4.9ALOGPS
pKa (Strongest Basic)9.52ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area29.54 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity102.88 m3·mol-1ChemAxon
Polarizability38.86 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.997
Blood Brain Barrier+0.9503
Caco-2 permeable+0.7277
P-glycoprotein substrateSubstrate0.5798
P-glycoprotein inhibitor IInhibitor0.7851
P-glycoprotein inhibitor IINon-inhibitor0.6469
Renal organic cation transporterNon-inhibitor0.6086
CYP450 2C9 substrateNon-substrate0.833
CYP450 2D6 substrateNon-substrate0.9117
CYP450 3A4 substrateSubstrate0.6032
CYP450 1A2 substrateInhibitor0.6357
CYP450 2C9 inhibitorNon-inhibitor0.7637
CYP450 2D6 inhibitorInhibitor0.6887
CYP450 2C19 inhibitorNon-inhibitor0.7628
CYP450 3A4 inhibitorNon-inhibitor0.7992
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.646
Ames testNon AMES toxic0.8896
CarcinogenicityCarcinogens 0.7164
BiodegradationNot ready biodegradable0.9714
Rat acute toxicity2.9360 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9033
hERG inhibition (predictor II)Inhibitor0.6837
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - CI-BGC-MSsplash10-067l-0393000000-d81188159d7476252fd4
GC-MS Spectrum - EI-BGC-MSsplash10-0a4i-9000000000-9c987f1baf068ed1fd6e
Mass Spectrum (Electron Ionization)MSsplash10-0a4i-9200000000-39d80ee06dde3e5036f4
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Stilbenes
Sub Class
Not Available
Direct Parent
Stilbenes
Alternative Parents
Phenylbutylamines / Benzyloxycarbonyls / Phenylpropanes / Aralkylamines / Trialkylamines / Carboxylic acid esters / Amino acids and derivatives / Monocarboxylic acids and derivatives / Organopnictogen compounds / Organic oxides
show 2 more
Substituents
Stilbene / Phenylbutylamine / Benzyloxycarbonyl / Phenylpropane / Aralkylamine / Monocyclic benzene moiety / Benzenoid / Tertiary aliphatic amine / Tertiary amine / Carboxylic acid ester
show 13 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate (CHEBI:51173)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Voltage-gated calcium channel activity
Specific Function
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone...
Gene Name
OPRM1
Uniprot ID
P35372
Uniprot Name
Mu-type opioid receptor
Molecular Weight
44778.855 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  2. Ulens C, Daenens P, Tytgat J: Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents. Cardiovasc Res. 1999 Dec;44(3):568-78. [PubMed:10690289]
  3. Tyers MB: A classification of opiate receptors that mediate antinociception in animals. Br J Pharmacol. 1980 Jul;69(3):503-12. [PubMed:6249436]
  4. Picker MJ: Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists. J Pharmacol Exp Ther. 1997 Dec;283(3):1009-17. [PubMed:9399970]
  5. Codd EE, Shank RP, Schupsky JJ, Raffa RB: Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70. [PubMed:7562497]
  6. Bannwarth B, Richez C: The dextropropoxyphene controversy. Joint Bone Spine. 2009 Oct;76(5):449-51. doi: 10.1016/j.jbspin.2009.04.004. Epub 2009 Jul 14. [PubMed:19604717]
  7. Walker EA, Tiano MJ, Benyas SI, Dykstra LA, Picker MJ: Naltrexone and beta-funaltrexamine antagonism of the antinociceptive and response rate-decreasing effects of morphine, dezocine, and d-propoxyphene. Psychopharmacology (Berl). 1999 May;144(1):45-53. [PubMed:10379623]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Opioid receptor activity
Specific Function
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine n...
Gene Name
OPRD1
Uniprot ID
P41143
Uniprot Name
Delta-type opioid receptor
Molecular Weight
40368.235 Da
References
  1. Neil A: Affinities of some common opioid analgesics towards four binding sites in mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):24-9. [PubMed:6151117]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Opioid receptor activity
Specific Function
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synt...
Gene Name
OPRK1
Uniprot ID
P41145
Uniprot Name
Kappa-type opioid receptor
Molecular Weight
42644.665 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  2. Neil A: Affinities of some common opioid analgesics towards four binding sites in mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):24-9. [PubMed:6151117]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Triglyceride lipase activity
Specific Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acy...
Gene Name
CES1
Uniprot ID
P23141
Uniprot Name
Liver carboxylesterase 1
Molecular Weight
62520.62 Da
References
  1. Zhang J, Burnell JC, Dumaual N, Bosron WF: Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1. J Pharmacol Exp Ther. 1999 Jul;290(1):314-8. [PubMed:10381793]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on June 13, 2005 07:24 / Updated on July 02, 2018 20:40