Identification
NameCobicistat
Accession NumberDB09065
TypeSmall Molecule
GroupsApproved
Description

Cobicistat, trade name Tybost (formerly GS-9350), is a licensed drug for use in the treatment of infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of coadministered agents that are metabolized by CYP3A enzymes. More specifically, cobicistat is indicated to increase systemic exposure of atazanavir or darunavir (once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 infection. Increasing systemic exposure of anti-retrovirals (ARVs) without increasing dosage allows for better treatment outcomes and a decreased side effect profile.

Structure
Thumb
Synonyms
1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate
External IDs GS 9350 / GS-9350 / GS9350
Product Ingredients Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
TybostTablet, film coated150 mgOralGilead Sciences2013-09-19Not applicableEu
TybostTablet150 mgOralGilead Sciences2015-04-10Not applicableCanada
TybostTablet, film coated150 mgOralGilead Sciences2013-09-19Not applicableEu
TybostTablet, film coated150 mg/1OralGilead Sciences2014-09-24Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
EvotazA S Medication Solutions
GenvoyaGilead Sciences
PrezcobixJanssen Pharmaceuticals
RezolstaJanssen Cilag International Nv
StribildState of Florida DOH Central Pharmacy
Categories
UNIILW2E03M5PG
CAS number1004316-88-4
WeightAverage: 776.03
Monoisotopic: 775.354960183
Chemical FormulaC40H53N7O5S2
InChI KeyZCIGNRJZKPOIKD-CQXVEOKZSA-N
InChI
InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1
IUPAC Name
(1,3-thiazol-5-yl)methyl N-[(2R,5R)-5-[(2S)-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}-4-(morpholin-4-yl)butanamido]-1,6-diphenylhexan-2-yl]carbamate
SMILES
CC(C)C1=NC(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[[email protected]](CC[[email protected]](CC2=CC=CC=C2)NC(=O)OCC2=CN=CS2)CC2=CC=CC=C2)=CS1
Pharmacology
Indication

Cobicistat is a CYP3A inhibitor indicated to increase systemic exposure of atazanavir or darunavir (once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 infection. It is not interchangeable with ritonavir to increase systemic exposure of darunavir 600 mg twice daily, fosamprenavir, saquinavir, or tipranavir due to lack of exposure data. The use of cobicistat is not recommended with darunavir 600 mg twice daily, fosamprenavir, saquinavir or tipranavir. Complex or unknown mechanisms of drug interactions preclude extrapolation of ritonavir drug interactions to certain cobicistat interactions. Cobicistat and ritonavir when administered with either atazanavir or darunavir may result in different drug interactions when used with concomitant medications.

Structured Indications
PharmacodynamicsNot Available
Mechanism of action

Cobicistat is a mechanism-based inhibitor of cytochrome P450 3A (CYP3A) isoforms. Inhibition of CYP3A-mediated metabolism by cobicistat increases the systemic exposure of CYP3A substrates atazanavir and darunavir and therefore enables increased anti-viral activity at a lower dosage. Cobicistat does not have any anti-HIV activity on its own.

TargetKindPharmacological actionActionsOrganismUniProt ID
Cytochrome p450 3A subfamilyProtein groupyes
Inhibitor
Humannot applicabledetails
Related Articles
Absorption

Median peak plasma concentrations were observed at 3.5 hours post-dose.

Volume of distributionNot Available
Protein binding

97-98% bound to human plasma proteins.

Metabolism

Cobicistat is metabolized by CYP3A and to a minor extent by CYP2D6 enzymes and does not undergo glucuronidation.

Route of elimination

With single dose administration of [14C] cobicistat after multiple dosing of cobicistat for six days, the mean percent of the administered dose excreted in feces and urine was 86.2% and 8.2%, respectively.

Half life

The terminal plasma half-life of cobicistat is approximately 3 to 4 hours.

ClearanceNot Available
Toxicity

The most common adverse reactions reported during clinical trials were jaundice (13%), ocular icterus (15%), and nausea (12%).

Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Cobicistat.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Cobicistat.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Cobicistat.Experimental, Illicit
4-MethoxyamphetamineThe serum concentration of 4-Methoxyamphetamine can be increased when it is combined with Cobicistat.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Cobicistat.Experimental, Illicit
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Cobicistat.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Cobicistat.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Cobicistat.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Cobicistat.Approved
AcetylcholineThe serum concentration of Acetylcholine can be increased when it is combined with Cobicistat.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Cobicistat.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Cobicistat.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Cobicistat.Approved
AjmalineThe serum concentration of Ajmaline can be increased when it is combined with Cobicistat.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Cobicistat.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Cobicistat.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Cobicistat.Experimental
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Cobicistat.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Cobicistat.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Cobicistat.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Cobicistat.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Cobicistat.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Cobicistat.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Cobicistat.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Cobicistat.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Cobicistat.Approved, Illicit, Investigational
AlprenololThe serum concentration of Alprenolol can be increased when it is combined with Cobicistat.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Cobicistat.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Cobicistat.Approved
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Cobicistat.Approved
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Cobicistat.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Cobicistat.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Cobicistat.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Cobicistat.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Cobicistat.Approved
AmoxapineThe serum concentration of Amoxapine can be increased when it is combined with Cobicistat.Approved
AmphetamineThe serum concentration of Amphetamine can be increased when it is combined with Cobicistat.Approved, Illicit
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Cobicistat.Approved
AmsacrineThe serum concentration of Amsacrine can be increased when it is combined with Cobicistat.Approved
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Cobicistat.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Cobicistat.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Cobicistat.Approved, Investigational
AprepitantThe metabolism of Aprepitant can be decreased when combined with Cobicistat.Approved, Investigational
AprindineThe serum concentration of Aprindine can be increased when it is combined with Cobicistat.Approved
ArformoterolThe serum concentration of Arformoterol can be increased when it is combined with Cobicistat.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Cobicistat.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Cobicistat.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Cobicistat.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Cobicistat.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Cobicistat.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Cobicistat.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Cobicistat.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Cobicistat.Approved
AtomoxetineThe serum concentration of Atomoxetine can be increased when it is combined with Cobicistat.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Cobicistat.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Cobicistat.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Cobicistat.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Cobicistat.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Cobicistat.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Cobicistat.Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Cobicistat.Approved
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Cobicistat.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Cobicistat.Approved
BenzatropineThe serum concentration of Benzatropine can be increased when it is combined with Cobicistat.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Cobicistat.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Cobicistat.Approved
BepridilThe serum concentration of Bepridil can be increased when it is combined with Cobicistat.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Cobicistat.Approved, Vet Approved
BetaxololThe serum concentration of Betaxolol can be increased when it is combined with Cobicistat.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Cobicistat.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Cobicistat.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Cobicistat.Approved
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Cobicistat.Approved
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Cobicistat.Approved, Investigational
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Cobicistat.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Cobicistat.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Cobicistat.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Cobicistat.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Cobicistat.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Cobicistat.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Cobicistat.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Cobicistat.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Cobicistat.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Cobicistat.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Cobicistat.Approved
BufuralolThe serum concentration of Bufuralol can be increased when it is combined with Cobicistat.Experimental, Investigational
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Cobicistat.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Cobicistat.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Cobicistat.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Cobicistat.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Cobicistat.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Cobicistat.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Cobicistat.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Cobicistat.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Cobicistat.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Cobicistat.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Cobicistat.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Cobicistat.Approved
CaptoprilThe serum concentration of Captopril can be increased when it is combined with Cobicistat.Approved
CarbamazepineThe serum concentration of Cobicistat can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Cobicistat.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Cobicistat.Approved
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Cobicistat.Approved
CarteololThe serum concentration of Carteolol can be increased when it is combined with Cobicistat.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Cobicistat.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Cobicistat.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Cobicistat.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Cobicistat.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Cobicistat.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Cobicistat.Withdrawn
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Cobicistat.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Cobicistat.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Cobicistat.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Cobicistat.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Cobicistat.Withdrawn
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Cobicistat.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Cobicistat.Approved, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Cobicistat.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Cobicistat.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Cobicistat.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Cobicistat.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Cobicistat.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Cobicistat.Approved
CinnarizineThe serum concentration of Cinnarizine can be increased when it is combined with Cobicistat.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Cobicistat.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Cobicistat.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Cobicistat.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Cobicistat.Approved
ClarithromycinThe serum concentration of Cobicistat can be increased when it is combined with Clarithromycin.Approved
ClevidipineThe serum concentration of Clevidipine can be increased when it is combined with Cobicistat.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Cobicistat.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Cobicistat.Approved, Illicit
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Cobicistat.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Cobicistat.Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Cobicistat.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Cobicistat.Approved
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Cobicistat.Approved, Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Cobicistat.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Cobicistat.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Cobicistat.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Cobicistat.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Cobicistat.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Cobicistat.Approved, Illicit
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Cobicistat.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Cobicistat.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Cobicistat.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Cobicistat.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Cobicistat.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Cobicistat.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Cobicistat.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Cobicistat.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Cobicistat.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Cobicistat.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Cobicistat.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Cobicistat.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Cobicistat.Approved
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Cobicistat.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Cobicistat.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Cobicistat.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Cobicistat.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Cobicistat.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Cobicistat.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Cobicistat.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Cobicistat.Approved, Investigational
DarunavirThe metabolism of Darunavir can be decreased when combined with Cobicistat.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Cobicistat.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Cobicistat.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Cobicistat.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Cobicistat.Approved
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Cobicistat.Investigational
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Cobicistat.Approved
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Cobicistat.Approved
DesogestrelThe serum concentration of Desogestrel can be increased when it is combined with Cobicistat.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Cobicistat.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Cobicistat.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Cobicistat.Approved
DexamethasoneThe serum concentration of Cobicistat can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Cobicistat.Approved, Investigational, Vet Approved
DexfenfluramineThe serum concentration of Dexfenfluramine can be increased when it is combined with Cobicistat.Approved, Illicit, Withdrawn
DexmethylphenidateThe serum concentration of Dexmethylphenidate can be increased when it is combined with Cobicistat.Approved
DextroamphetamineThe serum concentration of Dextroamphetamine can be increased when it is combined with Cobicistat.Approved, Illicit
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Cobicistat.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Cobicistat.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Cobicistat.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Cobicistat.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Cobicistat.Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Cobicistat.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Cobicistat.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Cobicistat.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Cobicistat.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Cobicistat.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Cobicistat.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Cobicistat.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Cobicistat.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Cobicistat.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Cobicistat.Illicit
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Cobicistat.Approved
DiphenhydramineThe serum concentration of Diphenhydramine can be increased when it is combined with Cobicistat.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Cobicistat.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Cobicistat.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Cobicistat.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Cobicistat.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Cobicistat.Approved
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Cobicistat.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Cobicistat.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Cobicistat.Approved
DopamineThe serum concentration of Dopamine can be increased when it is combined with Cobicistat.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Cobicistat.Approved
DoxazosinThe serum concentration of Doxazosin can be increased when it is combined with Cobicistat.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Cobicistat.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Cobicistat.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Cobicistat.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Cobicistat.Approved
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Cobicistat.Approved
DuloxetineThe serum concentration of Duloxetine can be increased when it is combined with Cobicistat.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Cobicistat.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Cobicistat.Approved
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Cobicistat.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Cobicistat.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Cobicistat.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Cobicistat.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Cobicistat.Approved, Vet Approved
EncainideThe serum concentration of Encainide can be increased when it is combined with Cobicistat.Approved, Withdrawn
EnclomipheneThe serum concentration of Enclomiphene can be increased when it is combined with Cobicistat.Investigational
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Cobicistat.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Cobicistat.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Cobicistat.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Cobicistat.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Cobicistat.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Cobicistat.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Cobicistat.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Cobicistat.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Cobicistat.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Cobicistat.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Cobicistat.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Cobicistat.Approved, Investigational
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Cobicistat.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Cobicistat.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Cobicistat.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Cobicistat.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Cobicistat.Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Cobicistat.Approved, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cobicistat.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Cobicistat.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Cobicistat.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Cobicistat.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Cobicistat.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Cobicistat.Approved
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Cobicistat.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Cobicistat.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be increased when it is combined with Cobicistat.Approved
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Cobicistat.Approved
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Cobicistat.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Cobicistat.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Cobicistat.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Cobicistat.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Cobicistat.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Cobicistat.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Cobicistat.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Cobicistat.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Cobicistat.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Cobicistat.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Cobicistat.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Cobicistat.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Cobicistat.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Cobicistat.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Cobicistat.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Cobicistat.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Cobicistat.Approved, Investigational
FlecainideThe serum concentration of Flecainide can be increased when it is combined with Cobicistat.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Cobicistat.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Cobicistat.Approved
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Cobicistat.Approved, Vet Approved
FlunarizineThe serum concentration of Flunarizine can be increased when it is combined with Cobicistat.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Cobicistat.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Cobicistat.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Cobicistat.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Cobicistat.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Cobicistat.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Cobicistat.Approved
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Cobicistat.Approved, Vet Approved
FluphenazineThe serum concentration of Fluphenazine can be increased when it is combined with Cobicistat.Approved
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Cobicistat.Approved, Withdrawn
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Cobicistat.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Cobicistat.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Cobicistat.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Cobicistat.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Cobicistat.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Cobicistat.Approved
FluvoxamineThe serum concentration of Fluvoxamine can be increased when it is combined with Cobicistat.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Cobicistat.Approved, Investigational, Withdrawn
FormoterolThe serum concentration of Formoterol can be increased when it is combined with Cobicistat.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Cobicistat.Approved
FosphenytoinThe serum concentration of Cobicistat can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Cobicistat.Approved, Investigational
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Cobicistat.Approved
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Cobicistat.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Cobicistat.Approved
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Cobicistat.Approved
GestodeneThe serum concentration of Gestodene can be increased when it is combined with Cobicistat.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Cobicistat.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Cobicistat.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Cobicistat.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Cobicistat.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Cobicistat.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Cobicistat.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Cobicistat.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Cobicistat.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Cobicistat.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Cobicistat.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Cobicistat.Withdrawn
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Cobicistat.Approved
HistamineThe metabolism of Histamine Phosphate can be decreased when combined with Cobicistat.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Cobicistat.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Cobicistat.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Cobicistat.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Cobicistat.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Cobicistat.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Cobicistat.Approved
IdarubicinThe serum concentration of Idarubicin can be increased when it is combined with Cobicistat.Approved
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Cobicistat.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Cobicistat resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Cobicistat.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Cobicistat.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Cobicistat.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Cobicistat.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Cobicistat.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Cobicistat.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Cobicistat.Approved
IndinavirThe metabolism of Indinavir can be decreased when combined with Cobicistat.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Cobicistat.Approved, Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Cobicistat.Approved
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Cobicistat.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Cobicistat.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Cobicistat.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Cobicistat.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Cobicistat.Approved
ItraconazoleThe serum concentration of Cobicistat can be increased when it is combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Cobicistat.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Cobicistat.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Cobicistat.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Cobicistat.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Cobicistat.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Cobicistat.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Cobicistat.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Cobicistat.Approved
KetoconazoleThe serum concentration of Cobicistat can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Cobicistat.Approved, Investigational
LabetalolThe serum concentration of Labetalol can be increased when it is combined with Cobicistat.Approved
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Cobicistat.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Cobicistat.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Cobicistat.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Cobicistat.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Cobicistat.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Cobicistat.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Cobicistat.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Cobicistat.Approved
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Cobicistat.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Cobicistat.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Cobicistat.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Cobicistat.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Cobicistat.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Cobicistat.Approved
LevodopaThe serum concentration of Levodopa can be increased when it is combined with Cobicistat.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Cobicistat.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Cobicistat.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Cobicistat.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Cobicistat.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Cobicistat.Approved
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Cobicistat.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Cobicistat.Approved
LisurideThe serum concentration of Lisuride can be increased when it is combined with Cobicistat.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Cobicistat.Approved
LomustineThe serum concentration of Lomustine can be increased when it is combined with Cobicistat.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Cobicistat.Approved
LopinavirThe metabolism of Lopinavir can be decreased when combined with Cobicistat.Approved
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Cobicistat.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Cobicistat.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Cobicistat.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Cobicistat.Approved, Investigational
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Cobicistat.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Cobicistat.Approved
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Cobicistat.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Cobicistat.Approved, Investigational
MaprotilineThe serum concentration of Maprotiline can be increased when it is combined with Cobicistat.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Cobicistat.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Cobicistat.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Cobicistat.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Cobicistat.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Cobicistat.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Cobicistat.Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Cobicistat.Approved, Vet Approved
MephenytoinThe serum concentration of Mephenytoin can be increased when it is combined with Cobicistat.Investigational, Withdrawn
MequitazineThe serum concentration of Mequitazine can be increased when it is combined with Cobicistat.Approved
MesoridazineThe serum concentration of Mesoridazine can be increased when it is combined with Cobicistat.Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Cobicistat.Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Cobicistat.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Cobicistat.Experimental
MethamphetamineThe serum concentration of Methamphetamine can be increased when it is combined with Cobicistat.Approved, Illicit
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Cobicistat.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Cobicistat.Approved
MethotrimeprazineThe serum concentration of Methotrimeprazine can be increased when it is combined with Cobicistat.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Cobicistat.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Cobicistat.Approved, Vet Approved
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Cobicistat.Approved
MethylphenidateThe serum concentration of Methylphenidate can be increased when it is combined with Cobicistat.Approved, Investigational
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Cobicistat.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Cobicistat.Approved
MethyprylonThe serum concentration of Methyprylon can be increased when it is combined with Cobicistat.Approved, Illicit, Withdrawn
MetoclopramideThe serum concentration of Metoclopramide can be increased when it is combined with Cobicistat.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Cobicistat.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Cobicistat.Approved
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Cobicistat.Approved
MianserinThe serum concentration of Mianserin can be increased when it is combined with Cobicistat.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Cobicistat.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Cobicistat.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Cobicistat.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Cobicistat.Approved, Investigational
MinaprineThe serum concentration of Minaprine can be increased when it is combined with Cobicistat.Approved
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Cobicistat.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Cobicistat.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Cobicistat.Approved, Investigational
MoclobemideThe serum concentration of Moclobemide can be increased when it is combined with Cobicistat.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Cobicistat.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Cobicistat.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Cobicistat.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Cobicistat.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Cobicistat.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Cobicistat.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Cobicistat.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Cobicistat.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Cobicistat.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Cobicistat.Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Cobicistat.Approved, Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Cobicistat.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Cobicistat.Approved
NetupitantThe serum concentration of Netupitant can be increased when it is combined with Cobicistat.Approved
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Cobicistat.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Cobicistat.Approved
NicergolineThe serum concentration of Nicergoline can be increased when it is combined with Cobicistat.Approved
NicotineThe serum concentration of Nicotine can be increased when it is combined with Cobicistat.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Cobicistat.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Cobicistat.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Cobicistat.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Cobicistat.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Cobicistat.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Cobicistat.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Cobicistat.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Cobicistat.Approved
NitrofuralThe serum concentration of Nitrofural can be increased when it is combined with Cobicistat.Approved, Vet Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Cobicistat.Approved
NorelgestrominThe serum concentration of Norelgestromin can be increased when it is combined with Cobicistat.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Cobicistat.Approved
NorgestimateThe serum concentration of Norgestimate can be increased when it is combined with Cobicistat.Approved
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Cobicistat.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Cobicistat.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Cobicistat.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Cobicistat.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Cobicistat.Investigational
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Cobicistat.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Cobicistat.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Cobicistat.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Cobicistat.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Cobicistat.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Cobicistat.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Cobicistat.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Cobicistat.Approved
OxcarbazepineThe serum concentration of Cobicistat can be decreased when it is combined with Oxcarbazepine.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Cobicistat.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Cobicistat is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Cobicistat.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Cobicistat.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Cobicistat.Approved
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Cobicistat.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Cobicistat.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Cobicistat.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Cobicistat.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Cobicistat.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Cobicistat.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Cobicistat.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Cobicistat.Approved
ParoxetineThe serum concentration of Paroxetine can be increased when it is combined with Cobicistat.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Cobicistat.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Cobicistat.Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Cobicistat.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Cobicistat.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Cobicistat.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Cobicistat.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Cobicistat.Approved
PethidineThe serum concentration of Pethidine can be increased when it is combined with Cobicistat.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Cobicistat.Withdrawn
PhenforminThe serum concentration of Phenformin can be increased when it is combined with Cobicistat.Approved, Withdrawn
PhenobarbitalThe serum concentration of Cobicistat can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Cobicistat.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Cobicistat.Approved
PhenytoinThe serum concentration of Cobicistat can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Cobicistat.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Cobicistat.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Cobicistat.Approved
PindololThe serum concentration of Pindolol can be increased when it is combined with Cobicistat.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Cobicistat.Approved, Investigational
PiperazineThe serum concentration of Piperazine can be increased when it is combined with Cobicistat.Approved, Vet Approved
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Cobicistat.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Cobicistat.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Cobicistat.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Cobicistat.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Cobicistat.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Cobicistat.Approved, Investigational, Vet Approved
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Cobicistat.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Cobicistat.Approved, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Cobicistat resulting in a loss in efficacy.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Cobicistat.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Cobicistat.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Cobicistat.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Cobicistat.Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Cobicistat.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Cobicistat.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Cobicistat.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Cobicistat.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Cobicistat.Experimental
PrimaquineThe metabolism of Primaquine can be decreased when combined with Cobicistat.Approved
PrimidoneThe serum concentration of Cobicistat can be decreased when it is combined with Primidone.Approved, Vet Approved
ProcainamideThe serum concentration of Procainamide can be increased when it is combined with Cobicistat.Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Cobicistat.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Cobicistat.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Cobicistat.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Cobicistat.Approved, Vet Approved
PromethazineThe serum concentration of Promethazine can be increased when it is combined with Cobicistat.Approved
PropafenoneThe serum concentration of Cobicistat can be increased when it is combined with Propafenone.Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Cobicistat.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Cobicistat.Approved, Investigational
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Cobicistat.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Cobicistat.Approved
PseudoephedrineThe serum concentration of Pseudoephedrine can be increased when it is combined with Cobicistat.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Cobicistat.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Cobicistat.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Cobicistat.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Cobicistat.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Cobicistat.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Cobicistat.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Cobicistat.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Cobicistat.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Cobicistat.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Cobicistat.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Cobicistat.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Cobicistat.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Cobicistat.Approved
RemoxiprideThe serum concentration of Remoxipride can be increased when it is combined with Cobicistat.Approved, Withdrawn
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Cobicistat.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Cobicistat.Approved
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Cobicistat.Approved
RifabutinThe metabolism of Rifabutin can be decreased when combined with Cobicistat.Approved
RifampicinThe serum concentration of Cobicistat can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Cobicistat can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Cobicistat.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Cobicistat.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Cobicistat.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Cobicistat.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Cobicistat.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Cobicistat.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Cobicistat.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Cobicistat.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Cobicistat.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Cobicistat.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Cobicistat.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Cobicistat.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Cobicistat.Approved
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Cobicistat.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Cobicistat.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Cobicistat.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Cobicistat.Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Cobicistat.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Cobicistat.Approved
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Cobicistat.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Cobicistat.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Cobicistat.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Cobicistat.Approved
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Cobicistat.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be increased when it is combined with Cobicistat.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Cobicistat.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Cobicistat.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Cobicistat.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Cobicistat.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Cobicistat.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Cobicistat.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Cobicistat.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Cobicistat.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Cobicistat.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Cobicistat.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Cobicistat.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Cobicistat.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Cobicistat.Approved
SparteineThe serum concentration of Sparteine can be increased when it is combined with Cobicistat.Experimental
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Cobicistat.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Cobicistat.Approved
St. John's WortThe serum concentration of Cobicistat can be decreased when it is combined with St. John's Wort.Nutraceutical
SufentanilThe metabolism of Sufentanil can be decreased when combined with Cobicistat.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Cobicistat.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Cobicistat.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Cobicistat.Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Cobicistat.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Cobicistat.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Cobicistat.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Cobicistat.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Cobicistat.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Cobicistat.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Cobicistat resulting in a loss in efficacy.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Cobicistat.Approved, Investigational
TapentadolThe serum concentration of Tapentadol can be increased when it is combined with Cobicistat.Approved
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Cobicistat.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Cobicistat.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Cobicistat.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Cobicistat.Approved
TegaserodThe serum concentration of Tegaserod can be increased when it is combined with Cobicistat.Investigational, Withdrawn
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Cobicistat.Withdrawn
TelithromycinThe serum concentration of Cobicistat can be increased when it is combined with Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Cobicistat.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Cobicistat.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Cobicistat.Approved
TenofovirThe risk or severity of adverse effects can be increased when Cobicistat is combined with Tenofovir.Approved, Investigational
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Cobicistat.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Cobicistat.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Cobicistat.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Cobicistat.Approved, Investigational
TetrabenazineThe serum concentration of Tetrabenazine can be increased when it is combined with Cobicistat.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Cobicistat.Approved, Vet Approved
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Cobicistat.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Cobicistat.Withdrawn
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Cobicistat.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Cobicistat.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Cobicistat resulting in a loss in efficacy.Approved
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Cobicistat.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Cobicistat.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Cobicistat.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Cobicistat.Approved
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Cobicistat.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Cobicistat.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Cobicistat.Approved, Investigational
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Cobicistat.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Cobicistat.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Cobicistat.Approved, Investigational
ToremifeneThe risk or severity of adverse effects can be increased when Cobicistat is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Cobicistat.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Cobicistat.Approved, Investigational
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Cobicistat.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Cobicistat.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Cobicistat.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Cobicistat.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Cobicistat.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Cobicistat.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Cobicistat.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Cobicistat.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Cobicistat.Withdrawn
UdenafilThe metabolism of Udenafil can be decreased when combined with Cobicistat.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Cobicistat.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Cobicistat.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Cobicistat.Investigational, Withdrawn
VandetanibThe metabolism of Vandetanib can be decreased when combined with Cobicistat.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Cobicistat.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Cobicistat.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Cobicistat.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Cobicistat.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Cobicistat.Approved
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Cobicistat.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Cobicistat.Approved
VilanterolThe metabolism of Vilanterol can be decreased when combined with Cobicistat.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Cobicistat.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Cobicistat.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Cobicistat.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Cobicistat.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Cobicistat.Approved
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Cobicistat.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Cobicistat.Approved
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Cobicistat.Approved
VoriconazoleThe serum concentration of Cobicistat can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Cobicistat.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Cobicistat.Approved
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Cobicistat.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Cobicistat.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Cobicistat.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Cobicistat.Approved, Illicit, Investigational
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Cobicistat.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Cobicistat.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Cobicistat.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Cobicistat.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Cobicistat.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Cobicistat.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Cobicistat.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Cobicistat.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General References
  1. German P, Warren D, West S, Hui J, Kearney BP: Pharmacokinetics and bioavailability of an integrase and novel pharmacoenhancer-containing single-tablet fixed-dose combination regimen for the treatment of HIV. J Acquir Immune Defic Syndr. 2010 Nov;55(3):323-9. doi: 10.1097/QAI.0b013e3181eb376b. [PubMed:20683270 ]
  2. Mathias AA, German P, Murray BP, Wei L, Jain A, West S, Warren D, Hui J, Kearney BP: Pharmacokinetics and pharmacodynamics of GS-9350: a novel pharmacokinetic enhancer without anti-HIV activity. Clin Pharmacol Ther. 2010 Mar;87(3):322-9. doi: 10.1038/clpt.2009.228. Epub 2009 Dec 30. [PubMed:20043009 ]
  3. Larson KB, Wang K, Delille C, Otofokun I, Acosta EP: Pharmacokinetic enhancers in HIV therapeutics. Clin Pharmacokinet. 2014 Oct;53(10):865-72. doi: 10.1007/s40262-014-0167-9. [PubMed:25164142 ]
  4. Lepist EI, Phan TK, Roy A, Tong L, Maclennan K, Murray B, Ray AS: Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro. Antimicrob Agents Chemother. 2012 Oct;56(10):5409-13. doi: 10.1128/AAC.01089-12. Epub 2012 Jul 30. [PubMed:22850510 ]
External Links
ATC CodesJ05AR18V03AX03J05AR14J05AR15J05AR09
AHFS Codes
  • 92:92
PDB EntriesNot Available
FDA labelDownload (467 KB)
MSDSNot Available
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingOtherHIV (Adult)1
1CompletedNot AvailableChronic Hepatitis C Infection / HIV Disease1
1CompletedNot AvailableHIV Disease2
1CompletedNot AvailableHIV-DDI1
1CompletedNot AvailableHuman Immunodeficiency Virus Type 1 (HIV-1)1
1CompletedBasic ScienceHIV-1 Infections1
1CompletedTreatmentDrug-drug Interaction Study1
1CompletedTreatmentHIV Disease2
1CompletedTreatmentHealthy Participants1
1CompletedTreatmentHealthy Volunteers4
1CompletedTreatmentInsulin Resistance1
1Not Yet RecruitingTreatmentHIV Disease1
1RecruitingHealth Services ResearchHIV Disease1
1RecruitingPreventionHuman Immunodeficiency Virus (HIV) Infections1
1RecruitingTreatmentInsulin Resistance1
1SuspendedOtherHealthy Volunteers1
2CompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections2
2CompletedTreatmentHIV Disease / Human Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentHIV-1 Infections1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2, 3Active Not RecruitingTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections1
2, 3Active Not RecruitingTreatmentHIV Disease1
2, 3RecruitingTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections1
2, 3WithdrawnTreatmentHIV/AIDS1
3Active Not RecruitingTreatmentAcquired Immune Deficiency Syndrome (AIDS) / HIV Disease / Human Immunodeficiency Virus (HIV) Infections1
3Active Not RecruitingTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections1
3Active Not RecruitingTreatmentHCV Infections / HIV-1 Infections1
3Active Not RecruitingTreatmentHIV Disease1
3Active Not RecruitingTreatmentHIV Disease / Human Immunodeficiency Virus (HIV) Infections4
3Active Not RecruitingTreatmentHIV-1 Infections5
3Active Not RecruitingTreatmentHepatitis C, Chronic / Human Immunodeficiency Virus (HIV)1
3CompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections5
3CompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections / Human Immunodeficiency Virus Type 1 (HIV-1)1
3CompletedTreatmentHBV / HIV Disease1
3CompletedTreatmentHIV Disease / Human Immunodeficiency Virus (HIV) Infections3
3CompletedTreatmentHIV Disease / Human Immunodeficiency Virus (HIV) Infections / Pregnancy1
3Not Yet RecruitingTreatmentHIV Risk1
3Not Yet RecruitingTreatmentHIV-1 Infections1
3RecruitingTreatmentHIV-1 Infections1
4Active Not RecruitingHealth Services ResearchHIV Disease1
4CompletedPreventionHIV Disease1
4CompletedPreventionHuman Immunodeficiency Virus (HIV)1
4CompletedTreatmentAids / HIV Disease / Sleep disorders and disturbances1
4CompletedTreatmentHIV-1 Infections1
4CompletedTreatmentHepatitis C Infection / Human Immunodeficiency Virus (HIV) Infections1
4Not Yet RecruitingOtherHealthy Volunteers1
4Not Yet RecruitingTreatmentHiv-positive1
4RecruitingOtherInfection, Human Immunodeficiency Virus I1
4RecruitingSupportive CareHIV Disease1
4RecruitingTreatmentAntiretroviral Therapy Intolerance / Patients Compliance1
4RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4TerminatedTreatmentAIDS-Related Dementia Complex1
Not AvailableCompletedBasic ScienceHIV Disease1
Not AvailableCompletedTreatmentHIV Disease1
Not AvailableRecruitingNot AvailableHIV Disease / Illicit Drug User1
Not AvailableRecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
TabletOral
Tablet, film coatedOral
TabletOral150 mg
Tablet, film coatedOral150 mg/1
Tablet, film coatedOral150 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5814639 Yes1996-03-292016-03-29Us
US5843946 Yes1996-06-012016-06-01Us
US5849911 Yes1997-12-202017-12-20Us
US5914331 Yes1998-01-022018-01-02Us
US5922695 Yes1998-01-252018-01-25Us
US5935946 Yes1998-01-252018-01-25Us
US5977089 Yes1998-01-252018-01-25Us
US6043230 Yes1998-01-252018-01-25Us
US6087383 Yes1999-06-212019-06-21Us
US6642245 Yes2001-05-042021-05-04Us
US6703396 Yes2001-09-092021-09-09Us
US7176220 No2003-11-202023-11-20Us
US7390791 No2002-05-072022-05-07Us
US7470506 Yes1999-12-232019-12-23Us
US7635704 No2006-10-262026-10-26Us
US7700645 Yes2007-06-262027-06-26Us
US7800788 No2002-02-022022-02-02Us
US7803788 No2002-02-022022-02-02Us
US8148374 No2009-09-032029-09-03Us
US8518987 Yes2004-08-162024-08-16Us
US8592397 No2004-01-132024-01-13Us
US8597876 Yes1999-12-232019-12-23Us
US8633219 No2010-04-242030-04-24Us
US8716264 No2004-01-132024-01-13Us
US8754065 No2012-08-152032-08-15Us
US8981103 No2006-10-262026-10-26Us
US9296769 No2012-08-152032-08-15Us
USRE42889 Yes1997-04-192017-04-19Us
USRE43596 Yes1997-11-092017-11-09Us
USRE43802 Yes1997-04-192017-04-19Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubility0.1 mg/mLFDA Label
Predicted Properties
PropertyValueSource
Water Solubility0.00125 mg/mLALOGPS
logP4.36ALOGPS
logP4.99ChemAxon
logS-5.8ALOGPS
pKa (Strongest Acidic)14.18ChemAxon
pKa (Strongest Basic)6.69ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area138.02 Å2ChemAxon
Rotatable Bond Count20ChemAxon
Refractivity211.49 m3·mol-1ChemAxon
Polarizability83.42 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET featuresNot Available
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as n-carbamoyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an carbamoyl group at its terminal nitrogen atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentN-carbamoyl-alpha amino acids and derivatives
Alternative ParentsAlpha amino acid amides / Amphetamines and derivatives / 2,4-disubstituted thiazoles / N-acyl amines / Morpholines / Heteroaromatic compounds / Carbamate esters / Ureas / Trialkylamines / Secondary carboxylic acid amides
SubstituentsN-carbamoyl-alpha-amino acid or derivatives / Alpha-amino acid amide / Amphetamine or derivatives / 2,4-disubstituted 1,3-thiazole / Monocyclic benzene moiety / Fatty amide / Morpholine / N-acyl-amine / Oxazinane / Benzenoid
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptorscarbamate ester, ureas, monocarboxylic acid amide, 1,3-thiazole, morpholines (CHEBI:72291 )

Targets

1. Cytochrome p450 3A subfamily
Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
Inhibitor
References
  1. Mathias AA, German P, Murray BP, Wei L, Jain A, West S, Warren D, Hui J, Kearney BP: Pharmacokinetics and pharmacodynamics of GS-9350: a novel pharmacokinetic enhancer without anti-HIV activity. Clin Pharmacol Ther. 2010 Mar;87(3):322-9. doi: 10.1038/clpt.2009.228. Epub 2009 Dec 30. [PubMed:20043009 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Mathias AA, German P, Murray BP, Wei L, Jain A, West S, Warren D, Hui J, Kearney BP: Pharmacokinetics and pharmacodynamics of GS-9350: a novel pharmacokinetic enhancer without anti-HIV activity. Clin Pharmacol Ther. 2010 Mar;87(3):322-9. doi: 10.1038/clpt.2009.228. Epub 2009 Dec 30. [PubMed:20043009 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Lepist EI, Phan TK, Roy A, Tong L, Maclennan K, Murray B, Ray AS: Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro. Antimicrob Agents Chemother. 2012 Oct;56(10):5409-13. doi: 10.1128/AAC.01089-12. Epub 2012 Jul 30. [PubMed:22850510 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Lepist EI, Phan TK, Roy A, Tong L, Maclennan K, Murray B, Ray AS: Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro. Antimicrob Agents Chemother. 2012 Oct;56(10):5409-13. doi: 10.1128/AAC.01089-12. Epub 2012 Jul 30. [PubMed:22850510 ]
Drug created on May 11, 2015 16:33 / Updated on June 22, 2017 10:03