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Identification
NameDarunavir
Accession NumberDB01264  (EXPT00002)
TypeSmall Molecule
GroupsApproved
DescriptionDarunavir is a protease inhibitor used to treat HIV. It acts on the HIV aspartyl protease which the virus needs to cleave the HIV polyprotein into its functional fragments.
Structure
Thumb
Synonyms
(3R,3AS,6ar)-hexahydrofuro[2,3-b]furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N(1)-isobutylsulfanilamido)propyl)carbamate
(3R,3AS,6ar)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate
(3R,3AS,6ar)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
(3R,3AS,6ar)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-neopentylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
[(S)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-1-((R)-phenylmethyl)-propyl]-carbamic acid (3R,3as,6ar)-(hexahydro-furo[2,3-b]furan-3-yl) ester
{(1S,2R)-3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid (3R,3as,6ar)-(hexahydro-furo[2,3-b]furan-3-yl) ester
Darunavir
Darunavirum
N-((1S,2R)-3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-benzylpropyl)((1S,2R,5R)-4,6-dioxabicyclo(3.3.0)oct-2-yloxy)carboxamide
TMC-114
TMC114
External Identifiers
  • AIDS073035
  • TMC114
  • UIC-94017
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Pat-darunavirTablet75 mgOralPatriot A Division Of Janssen IncNot applicableNot applicableCanada
Pat-darunavirTablet400 mgOralPatriot A Division Of Janssen IncNot applicableNot applicableCanada
Pat-darunavirTablet600 mgOralPatriot A Division Of Janssen IncNot applicableNot applicableCanada
Pat-darunavirTablet150 mgOralPatriot A Division Of Janssen IncNot applicableNot applicableCanada
Pat-darunavirTablet800 mgOralPatriot A Division Of Janssen IncNot applicableNot applicableCanada
PrezistaTablet150 mgOralJanssen Inc2012-04-16Not applicableCanada
PrezistaTablet, film coated800 mgOralJanssen Cilag International Nv2007-02-12Not applicableEu
PrezistaTablet, film coated400 mg/1OralREMEDYREPACK INC.2013-05-092016-10-13Us
PrezistaTablet, film coated800 mg/1OralA S Medication Solutions2012-11-09Not applicableUs
PrezistaSuspension100 mgOralJanssen Inc2014-08-06Not applicableCanada
PrezistaTablet, film coated75 mg/1OralJanssen Products LP2009-01-14Not applicableUs
PrezistaTablet, film coated150 mgOralJanssen Cilag International Nv2007-02-12Not applicableEu
PrezistaTablet, film coated600 mg/1OralPhysicians Total Care, Inc.2012-10-16Not applicableUs
PrezistaTablet800 mgOralJanssen Inc2012-11-09Not applicableCanada
PrezistaTablet, film coated800 mgOralJanssen Cilag International Nv2007-02-12Not applicableEu
PrezistaTablet, film coated400 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
PrezistaTablet, film coated600 mg/1OralA S Medication Solutions2008-03-08Not applicableUs
PrezistaTablet, film coated300 mgOralJanssen Cilag International Nv2007-02-12Not applicableEu
PrezistaTablet, film coated150 mg/1OralJanssen Products LP2009-04-27Not applicableUs
PrezistaTablet, film coated75 mgOralJanssen Cilag International Nv2007-02-12Not applicableEu
PrezistaTablet600 mgOralJanssen Inc2009-03-17Not applicableCanada
PrezistaTablet300 mgOralJanssen Inc2006-08-092011-07-27Canada
PrezistaTablet, film coated800 mg/1OralREMEDYREPACK INC.2013-04-09Not applicableUs
PrezistaTablet, film coated600 mgOralJanssen Cilag International Nv2007-02-12Not applicableEu
PrezistaTablet, film coated600 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
PrezistaTablet, film coated600 mg/1OralA S Medication Solutions2008-03-08Not applicableUs
PrezistaSuspension100 mg/mLOralJanssen Products LP2011-12-16Not applicableUs
PrezistaTablet75 mgOralJanssen Inc2009-12-16Not applicableCanada
PrezistaSuspension100 mg/mlOralJanssen Cilag International Nv2007-02-12Not applicableEu
PrezistaTablet, film coated600 mg/1OralJanssen Products LP2008-03-08Not applicableUs
PrezistaTablet, film coated400 mgOralJanssen Cilag International Nv2007-02-12Not applicableEu
PrezistaTablet, film coated400 mg/1OralPhysicians Total Care, Inc.2008-12-09Not applicableUs
PrezistaTablet400 mgOralJanssen Inc2009-04-012016-09-01Canada
PrezistaTablet, film coated800 mg/1OralJanssen Products LP2012-11-09Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
PrezcobixJanssen Inc
RezolstaJanssen Cilag International N.V.
Salts
Name/CASStructureProperties
Darunavir ethanolate
ThumbNot applicableDBSALT001338
Categories
UNIIYO603Y8113
CAS number206361-99-1
WeightAverage: 547.664
Monoisotopic: 547.235221243
Chemical FormulaC27H37N3O7S
InChI KeyCJBJHOAVZSMMDJ-HEXNFIEUSA-N
InChI
InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1
IUPAC Name
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)4-aminobenzenesulfonamido]-1-phenylbutan-2-yl]carbamate
SMILES
[H][C@@]12CCO[C@]1([H])OC[C@@H]2OC(=O)N[C@@H](CC1=CC=CC=C1)[[email protected]](O)CN(CC(C)C)S(=O)(=O)C1=CC=C(N)C=C1
Pharmacology
IndicationDarunavir, co-administered with ritonavir, and with other antiretroviral agents, is indicated for the treatment of human immunodeficiency virus (HIV) infection in antiretroviral treatment-experienced adult patients, such as those with HIV-1 strains resistant to more than one protease inhibitor.
Structured Indications
PharmacodynamicsDarunavir is an inhibitor of the human immunodeficiency virus (HIV) protease. In studies, the drug, co-administered with ritonavir in combination therapy, significantly reduced viral load and increased CD4 cell counts in this treatment-experienced patient population (Tibotec, 2006, Product Monograph, Prezista 2006). Darunavir is used as an adjunct therapy with low dose ritonavir, which inhibits cytochrome P450 3A (CYP3A) which increases the bioavailability and half life of darunavir.
Mechanism of actionDarunavir is a HIV protease inhibitor which prevents HIV replication by binding to the enzyme's active site, thereby preventing the dimerization and the catalytic activity of the HIV-1 protease. Darunavir selectively inhibits the cleavage of HIV encoded Gag-Pol polyproteins in virus-infected cells, which prevents the formation of mature infectious virus particles. Structual analyses suggests that the close contact that darunavir has with the main chains of the protease active site amino acids (Asp-29 and Asp-30) is an important contributing factor to its potency and wide spectrum of activity against multi-protease inhibitor resistant HIV-1 variants. Darunavir can also adapt to the changing shape of a protease enzyme because of its molecular flexibility. Darunavir is known to bind to two distinct sites on the enzyme: the active site cavity and the surface of one of the flexible flaps in the protease dimer.
TargetKindPharmacological actionActionsOrganismUniProt ID
Pol polyproteinProteinyes
inhibitor
Human immunodeficiency virus 1Q72874 details
Related Articles
AbsorptionThe absolute oral bioavailability of a single 600 mg dose of darunavir alone and after co-administration with 100 mg ritonavir twice daily was 37% and 82%, respectively.
Volume of distributionNot Available
Protein bindingDarunavir is approximately 95% bound to plasma proteins. Darunavir binds primarily to plasma alpha 1-acid glycoprotein (AAG).
Metabolism

Hepatic. Darunavir is extensively metabolized by CYP enzymes, primarily by CYP3A.

Route of eliminationDarunavir is primarily metabolized by CYP3A. Darunavir is extensively metabolized by CYP enzymes, primarily by CYP3A. A mass balance study in healthy volunteers showed that after single dose administration of 400 mg 14C-darunavir, co-administered with 100 mg ritonavir, approximately 79.5% and 13.9% of the administered dose of 14C-darunavir was recovered in the feces and urine, respectively.
Half lifeThe terminal elimination half-life of darunavir was approximately 15 hours when combined with ritonavir.
Clearance
  • 32.8 L/hr [Healthy volunteers receiving intravenous administration of 400 mg of darunavir]
  • 5.9 L/hr [Healthy volunteers receiving intravenous administrations of 400 mg of darunavir and 100 mg of ritonavir twice daily]
ToxicityNot Available
Affected organisms
  • Human Immunodeficiency Virus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Darunavir.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Darunavir.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Darunavir.Experimental, Illicit
4-MethoxyamphetamineThe serum concentration of 4-Methoxyamphetamine can be increased when it is combined with Darunavir.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Darunavir.Experimental, Illicit
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Darunavir.Approved, Investigational
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Darunavir.Approved
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Darunavir.Approved, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Darunavir.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Darunavir.Approved
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Darunavir.Withdrawn
AcetylcholineThe serum concentration of Acetylcholine can be increased when it is combined with Darunavir.Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Darunavir.Approved
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Darunavir.Experimental
AjmalineThe serum concentration of Ajmaline can be increased when it is combined with Darunavir.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Darunavir.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Darunavir.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Darunavir.Experimental
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Darunavir.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Darunavir.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Darunavir.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Darunavir.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Darunavir.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Darunavir.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Darunavir.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Darunavir.Approved, Illicit, Investigational
AlprenololThe serum concentration of Alprenolol can be increased when it is combined with Darunavir.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Darunavir.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Darunavir.Approved
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Darunavir.Experimental
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Darunavir.Approved
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Darunavir.Illicit, Withdrawn
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Darunavir.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Darunavir.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Darunavir.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Darunavir.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Darunavir.Approved
AmoxapineThe serum concentration of Amoxapine can be increased when it is combined with Darunavir.Approved
AmphetamineThe serum concentration of Amphetamine can be increased when it is combined with Darunavir.Approved, Illicit
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Darunavir.Approved
AmsacrineThe serum concentration of Amsacrine can be increased when it is combined with Darunavir.Approved
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Darunavir.Investigational
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Darunavir.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Darunavir.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Darunavir.Approved, Investigational
AprepitantThe serum concentration of Darunavir can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe serum concentration of Aprindine can be increased when it is combined with Darunavir.Approved
ArformoterolThe serum concentration of Arformoterol can be increased when it is combined with Darunavir.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Darunavir.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Darunavir.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Darunavir.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Darunavir.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Darunavir.Approved, Withdrawn
AtazanavirThe metabolism of Darunavir can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe serum concentration of Atomoxetine can be increased when it is combined with Darunavir.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Darunavir.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Darunavir.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Darunavir.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Darunavir.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Darunavir.Approved
BalaglitazoneThe therapeutic efficacy of Balaglitazone can be decreased when used in combination with Darunavir.Investigational
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Darunavir.Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Darunavir.Approved
BeclomethasoneThe serum concentration of Beclomethasone can be increased when it is combined with Darunavir.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Darunavir.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Darunavir.Approved
BenzatropineThe serum concentration of Benzatropine can be increased when it is combined with Darunavir.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Darunavir.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Darunavir.Approved
BepridilThe serum concentration of Bepridil can be increased when it is combined with Darunavir.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Darunavir.Approved, Vet Approved
BetaxololThe serum concentration of Betaxolol can be increased when it is combined with Darunavir.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Darunavir.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Darunavir.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Darunavir.Approved
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Darunavir.Approved
BoceprevirThe serum concentration of Darunavir can be decreased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Darunavir.Approved, Investigational
BosentanThe serum concentration of Darunavir can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Darunavir.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Darunavir.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Darunavir.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Darunavir.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Darunavir.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Darunavir.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Darunavir.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Darunavir.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Darunavir.Approved
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Darunavir.Withdrawn
BufuralolThe serum concentration of Bufuralol can be increased when it is combined with Darunavir.Experimental, Investigational
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Darunavir.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Darunavir.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Darunavir.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Darunavir.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Darunavir.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Darunavir.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Darunavir.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Darunavir.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Darunavir.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Darunavir.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Darunavir.Approved
CaptoprilThe serum concentration of Captopril can be increased when it is combined with Darunavir.Approved
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Darunavir.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Darunavir.Approved
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Darunavir.Approved
CarteololThe serum concentration of Carteolol can be increased when it is combined with Darunavir.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Darunavir.Approved, Investigational
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Darunavir.Experimental
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Darunavir.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Darunavir.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Darunavir.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Darunavir.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Darunavir.Withdrawn
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Darunavir.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Darunavir.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Darunavir.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Darunavir.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Darunavir.Withdrawn
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Darunavir.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Darunavir.Approved, Vet Approved
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Darunavir.Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Darunavir.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Darunavir.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Darunavir.Approved, Investigational
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Darunavir.Experimental
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Darunavir.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Darunavir.Approved
CinnarizineThe serum concentration of Cinnarizine can be increased when it is combined with Darunavir.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Darunavir.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Darunavir.Approved
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Darunavir.Approved
ClemastineThe metabolism of Darunavir can be decreased when combined with Clemastine.Approved
ClevidipineThe serum concentration of Clevidipine can be increased when it is combined with Darunavir.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Darunavir.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Darunavir.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Darunavir.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Darunavir.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Darunavir.Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Darunavir.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Darunavir.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Darunavir.Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Darunavir.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Darunavir.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Darunavir.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Darunavir.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Darunavir.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Darunavir.Approved, Illicit
ClotrimazoleThe metabolism of Darunavir can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Darunavir.Approved
CobicistatThe metabolism of Darunavir can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Darunavir.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Darunavir.Approved, Illicit
CodeineThe serum concentration of Codeine can be increased when it is combined with Darunavir.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Darunavir.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Darunavir.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Darunavir.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Darunavir.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Darunavir.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Darunavir.Approved
CyclophosphamideThe risk or severity of adverse effects can be increased when Darunavir is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Darunavir.Approved, Investigational, Vet Approved
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Darunavir.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Darunavir.Approved, Investigational
DabrafenibThe serum concentration of Darunavir can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Darunavir.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Darunavir.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Darunavir.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Darunavir.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Darunavir.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Darunavir.Approved, Investigational
DasabuvirThe serum concentration of Darunavir can be decreased when it is combined with Dasabuvir.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Darunavir.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Darunavir.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Darunavir.Approved
DeferasiroxThe serum concentration of Darunavir can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Darunavir.Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Darunavir.Approved
DeoxyspergualinThe therapeutic efficacy of Deoxyspergualin can be decreased when used in combination with Darunavir.Investigational
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Darunavir.Approved
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Darunavir.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Darunavir.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Darunavir.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Darunavir.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Darunavir.Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Darunavir.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Darunavir.Vet Approved
DexfenfluramineThe serum concentration of Dexfenfluramine can be increased when it is combined with Darunavir.Approved, Illicit, Withdrawn
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Darunavir.Approved
DexmethylphenidateThe serum concentration of Dexmethylphenidate can be increased when it is combined with Darunavir.Approved
DextroamphetamineThe serum concentration of Dextroamphetamine can be increased when it is combined with Darunavir.Approved, Illicit
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Darunavir.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Darunavir.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Darunavir.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Darunavir.Approved, Vet Approved
DidanosineThe serum concentration of Didanosine can be decreased when it is combined with Darunavir.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Darunavir.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Darunavir.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Darunavir.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Darunavir.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Darunavir.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Darunavir.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Darunavir.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Darunavir.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Darunavir.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Darunavir.Approved
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Darunavir.Approved
DiphenhydramineThe serum concentration of Diphenhydramine can be increased when it is combined with Darunavir.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Darunavir.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Darunavir.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Darunavir.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Darunavir.Approved
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Darunavir.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Darunavir.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Darunavir.Approved
DopamineThe serum concentration of Dopamine can be increased when it is combined with Darunavir.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Darunavir.Approved
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Darunavir.Approved
DoxazosinThe serum concentration of Doxazosin can be increased when it is combined with Darunavir.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Darunavir.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Darunavir.Approved, Investigational
DoxycyclineThe metabolism of Darunavir can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Darunavir.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Darunavir.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Darunavir.Approved
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Darunavir.Approved
DuloxetineThe serum concentration of Duloxetine can be increased when it is combined with Darunavir.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Darunavir.Approved, Investigational
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Darunavir.Approved
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Darunavir.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Darunavir.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Darunavir.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Darunavir.Approved
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Darunavir.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Darunavir.Approved, Vet Approved
EncainideThe serum concentration of Encainide can be increased when it is combined with Darunavir.Approved, Withdrawn
EnclomipheneThe serum concentration of Enclomiphene can be increased when it is combined with Darunavir.Investigational
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Darunavir.Approved, Investigational
EnzalutamideThe serum concentration of Darunavir can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Darunavir.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Darunavir.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Darunavir.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Darunavir.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Darunavir.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Darunavir.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Darunavir.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Darunavir.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Darunavir.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Darunavir.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Darunavir.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Darunavir can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Darunavir.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Darunavir.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Darunavir.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Darunavir.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Darunavir.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Darunavir.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Darunavir.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Darunavir.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Darunavir.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Darunavir.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Darunavir.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Darunavir.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Darunavir.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Darunavir.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Darunavir.Approved
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Darunavir.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Darunavir.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Darunavir.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Darunavir.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Darunavir.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Darunavir.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Darunavir.Approved, Investigational
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Darunavir.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Darunavir.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Darunavir.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Darunavir.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Darunavir.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Darunavir.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Darunavir.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Darunavir.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Darunavir.Approved, Investigational
FlecainideThe serum concentration of Flecainide can be increased when it is combined with Darunavir.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Darunavir.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Darunavir.Investigational
FluconazoleThe metabolism of Darunavir can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Darunavir.Approved
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Darunavir.Approved, Vet Approved
FlunarizineThe serum concentration of Flunarizine can be increased when it is combined with Darunavir.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Darunavir.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Darunavir.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Darunavir.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Darunavir.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Darunavir.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Darunavir.Approved
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Darunavir.Approved, Vet Approved
FluphenazineThe serum concentration of Fluphenazine can be increased when it is combined with Darunavir.Approved
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Darunavir.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Darunavir.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Darunavir.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Darunavir.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Darunavir.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Darunavir.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Darunavir.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Darunavir.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Darunavir.Approved
FluvoxamineThe serum concentration of Fluvoxamine can be increased when it is combined with Darunavir.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Darunavir.Approved, Investigational, Withdrawn
FormoterolThe serum concentration of Formoterol can be increased when it is combined with Darunavir.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Darunavir.Approved
FosaprepitantThe serum concentration of Darunavir can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Darunavir can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Darunavir.Approved, Investigational
Fusidic AcidThe serum concentration of Darunavir can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Darunavir.Approved
GarlicThe serum concentration of Darunavir can be decreased when it is combined with Garlic.Approved
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Darunavir.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Darunavir.Approved
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Darunavir.Approved
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Darunavir.Withdrawn
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Darunavir.Approved
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Darunavir.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Darunavir.Approved
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Darunavir.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Darunavir.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Darunavir.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Darunavir.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Darunavir.Approved, Investigational
GusperimusThe therapeutic efficacy of Gusperimus can be decreased when used in combination with Darunavir.Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Darunavir.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Darunavir.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Darunavir.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Darunavir.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Darunavir.Withdrawn
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Darunavir.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Darunavir.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Darunavir.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Darunavir.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Darunavir.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Darunavir.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Darunavir.Approved
IdarubicinThe serum concentration of Idarubicin can be increased when it is combined with Darunavir.Approved
IdelalisibThe serum concentration of Darunavir can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Darunavir resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Darunavir.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Darunavir.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Darunavir.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Darunavir.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Darunavir.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Darunavir.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Darunavir.Approved
IndinavirThe metabolism of Darunavir can be decreased when combined with Indinavir.Approved
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Darunavir.Approved
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Darunavir.Approved
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Darunavir.Approved
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Darunavir.Approved
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Darunavir.Approved
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Darunavir.Approved
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Darunavir.Approved
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Darunavir.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Darunavir.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Darunavir.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Darunavir.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Darunavir.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Darunavir.Investigational
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Darunavir.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Darunavir.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Darunavir.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Darunavir.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Darunavir.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Darunavir.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Darunavir.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Darunavir.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Darunavir.Approved
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Darunavir.Approved, Investigational
KetoconazoleThe metabolism of Darunavir can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolThe serum concentration of Labetalol can be increased when it is combined with Darunavir.Approved
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Darunavir.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Darunavir.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Darunavir.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Darunavir.Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Darunavir.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Darunavir.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Darunavir.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Darunavir.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Darunavir.Approved
LevodopaThe serum concentration of Levodopa can be increased when it is combined with Darunavir.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Darunavir.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Darunavir.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Darunavir.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Darunavir.Approved
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Darunavir.Approved, Vet Approved
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Darunavir.Approved
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Darunavir.Approved
LisurideThe serum concentration of Lisuride can be increased when it is combined with Darunavir.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Darunavir.Approved
LomustineThe serum concentration of Lomustine can be increased when it is combined with Darunavir.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Darunavir.Approved
LopinavirThe serum concentration of Darunavir can be decreased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Darunavir.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Darunavir.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Darunavir.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Darunavir.Approved, Investigational
LuliconazoleThe serum concentration of Darunavir can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Darunavir can be increased when combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Darunavir.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Darunavir.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Darunavir.Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Darunavir.Approved
MaprotilineThe serum concentration of Maprotiline can be increased when it is combined with Darunavir.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Darunavir.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Darunavir.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Darunavir.Approved, Vet Approved
MecamylamineThe risk or severity of adverse effects can be increased when Darunavir is combined with Mecamylamine.Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Darunavir.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Darunavir.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Darunavir.Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Darunavir.Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Darunavir.Approved, Vet Approved
MephenytoinThe serum concentration of Mephenytoin can be increased when it is combined with Darunavir.Investigational, Withdrawn
MequitazineThe serum concentration of Mequitazine can be increased when it is combined with Darunavir.Approved
MesoridazineThe serum concentration of Mesoridazine can be increased when it is combined with Darunavir.Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Darunavir.Approved
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Darunavir.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Darunavir.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Darunavir.Experimental
MethamphetamineThe serum concentration of Methamphetamine can be increased when it is combined with Darunavir.Approved, Illicit
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Darunavir.Illicit, Withdrawn
MethotrimeprazineThe serum concentration of Methotrimeprazine can be increased when it is combined with Darunavir.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Darunavir.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Darunavir.Approved, Vet Approved
MethylphenidateThe serum concentration of Methylphenidate can be increased when it is combined with Darunavir.Approved, Investigational
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Darunavir.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Darunavir.Approved
MethyprylonThe serum concentration of Methyprylon can be increased when it is combined with Darunavir.Approved, Illicit, Withdrawn
MetoclopramideThe serum concentration of Metoclopramide can be increased when it is combined with Darunavir.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Darunavir.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Darunavir.Approved
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Darunavir.Approved
MianserinThe serum concentration of Mianserin can be increased when it is combined with Darunavir.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Darunavir.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Darunavir.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Darunavir.Approved, Illicit
MifepristoneThe serum concentration of Darunavir can be increased when it is combined with Mifepristone.Approved, Investigational
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Darunavir.Approved
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Darunavir.Approved
MinaprineThe serum concentration of Minaprine can be increased when it is combined with Darunavir.Approved
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Darunavir.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Darunavir.Approved
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Darunavir.Approved, Investigational
MitotaneThe serum concentration of Darunavir can be decreased when it is combined with Mitotane.Approved
MoclobemideThe serum concentration of Moclobemide can be increased when it is combined with Darunavir.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Darunavir.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Darunavir.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Darunavir.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Darunavir.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Darunavir.Approved, Investigational
NafcillinThe serum concentration of Darunavir can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Darunavir.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Darunavir.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Darunavir.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Darunavir.Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Darunavir.Approved, Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Darunavir.Approved, Withdrawn
NelfinavirThe metabolism of Darunavir can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Darunavir can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Darunavir.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Darunavir.Approved
NicergolineThe serum concentration of Nicergoline can be increased when it is combined with Darunavir.Approved
NicotineThe serum concentration of Nicotine can be increased when it is combined with Darunavir.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Darunavir.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Darunavir.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Darunavir.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Darunavir.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Darunavir.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Darunavir.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Darunavir.Approved
NitrofuralThe serum concentration of Nitrofural can be increased when it is combined with Darunavir.Approved, Vet Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Darunavir.Approved
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Darunavir.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Darunavir.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Darunavir.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Darunavir.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Darunavir.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Darunavir.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Darunavir.Investigational
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Darunavir.Approved
OmbitasvirThe serum concentration of Darunavir can be decreased when it is combined with Ombitasvir.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Darunavir.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Darunavir.Approved
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Darunavir.Investigational
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Darunavir.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Darunavir.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Darunavir.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Darunavir.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Darunavir.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Darunavir is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Darunavir.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Darunavir.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Darunavir.Approved
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Darunavir.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Darunavir.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Darunavir.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Darunavir.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Darunavir.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Darunavir.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Darunavir.Approved, Investigational
ParitaprevirThe serum concentration of Darunavir can be decreased when it is combined with Paritaprevir.Approved
ParoxetineThe serum concentration of Paroxetine can be decreased when it is combined with Darunavir.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Darunavir.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Darunavir.Approved
PentobarbitalThe metabolism of Darunavir can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Darunavir.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Darunavir.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Darunavir.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Darunavir.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Darunavir.Approved
PethidineThe risk or severity of adverse effects can be increased when Darunavir is combined with Pethidine.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Darunavir.Withdrawn
PhenforminThe serum concentration of Phenformin can be increased when it is combined with Darunavir.Approved, Withdrawn
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Darunavir.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Darunavir.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Darunavir.Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Darunavir.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Darunavir.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Darunavir.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Darunavir.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Darunavir.Withdrawn
PindololThe serum concentration of Pindolol can be increased when it is combined with Darunavir.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Darunavir.Approved, Investigational
PiperazineThe serum concentration of Piperazine can be increased when it is combined with Darunavir.Approved, Vet Approved
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Darunavir.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Darunavir.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Darunavir.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Darunavir.Approved
PosaconazoleThe metabolism of Darunavir can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Darunavir.Approved, Investigational
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Darunavir.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Darunavir.Approved, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Darunavir resulting in a loss in efficacy.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Darunavir.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Darunavir.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Darunavir.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Darunavir.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Darunavir.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Darunavir.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Darunavir.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Darunavir.Experimental
PrimaquineThe metabolism of Primaquine can be decreased when combined with Darunavir.Approved
PrimidoneThe metabolism of Darunavir can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideThe serum concentration of Procainamide can be increased when it is combined with Darunavir.Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Darunavir.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Darunavir.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Darunavir.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Darunavir.Approved, Vet Approved
PromethazineThe serum concentration of Promethazine can be increased when it is combined with Darunavir.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Darunavir.Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Darunavir.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Darunavir.Approved, Investigational
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Darunavir.Approved
PseudoephedrineThe serum concentration of Pseudoephedrine can be increased when it is combined with Darunavir.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Darunavir.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Darunavir.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Darunavir.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Darunavir.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Darunavir.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Darunavir.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Darunavir.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Darunavir.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Darunavir.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Darunavir.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Darunavir.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Darunavir.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Darunavir.Approved
RemoxiprideThe serum concentration of Remoxipride can be increased when it is combined with Darunavir.Approved, Withdrawn
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Darunavir.Approved, Investigational
repinotanThe serum concentration of repinotan can be increased when it is combined with Darunavir.Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Darunavir.Approved
RifabutinThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Darunavir.Approved
RifampicinThe serum concentration of Darunavir can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Darunavir can be decreased when it is combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Darunavir.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Darunavir.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Darunavir.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Darunavir.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Darunavir.Approved, Investigational
RitonavirThe serum concentration of Darunavir can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Darunavir.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Darunavir.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Darunavir.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Darunavir.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Darunavir.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Darunavir.Approved
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Darunavir.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Darunavir.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Darunavir.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Darunavir.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Darunavir.Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Darunavir.Approved
SaquinavirThe serum concentration of Darunavir can be decreased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Darunavir.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Darunavir.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Darunavir.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Darunavir.Approved, Investigational
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Darunavir.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Darunavir.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Darunavir.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Darunavir.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Darunavir.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Darunavir.Approved
SiltuximabThe serum concentration of Darunavir can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Darunavir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Darunavir.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Darunavir.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Darunavir.Approved, Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Darunavir.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Darunavir.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Darunavir.Approved, Investigational
SparteineThe serum concentration of Sparteine can be increased when it is combined with Darunavir.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Darunavir.Approved
St. John's WortThe metabolism of Darunavir can be increased when combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Darunavir can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Darunavir.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Darunavir.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Darunavir.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Darunavir.Approved
SulfisoxazoleThe metabolism of Darunavir can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Darunavir.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Darunavir.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Darunavir.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Darunavir.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Darunavir.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Darunavir.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Darunavir.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Darunavir.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Darunavir.Approved, Investigational
TapentadolThe serum concentration of Tapentadol can be increased when it is combined with Darunavir.Approved
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Darunavir.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Darunavir.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Darunavir.Experimental
TegaserodThe serum concentration of Tegaserod can be increased when it is combined with Darunavir.Investigational, Withdrawn
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Darunavir.Approved
TelithromycinThe metabolism of Darunavir can be decreased when combined with Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Darunavir.Approved
TemsirolimusThe risk or severity of adverse effects can be increased when Darunavir is combined with Temsirolimus.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Darunavir.Approved
TenofovirThe serum concentration of Darunavir can be increased when it is combined with Tenofovir.Approved, Investigational
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Darunavir.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Darunavir.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Darunavir.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Darunavir.Approved, Investigational
TetrabenazineThe serum concentration of Tetrabenazine can be increased when it is combined with Darunavir.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Darunavir.Approved, Vet Approved
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Darunavir.Approved
ThiazolidinedioneThe therapeutic efficacy of Thiazolidinedione can be decreased when used in combination with Darunavir.Investigational
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Darunavir.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Darunavir.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Darunavir.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Darunavir.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Darunavir resulting in a loss in efficacy.Approved
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Darunavir.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Darunavir.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Darunavir.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Darunavir.Approved
TipranavirThe serum concentration of Darunavir can be decreased when it is combined with Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Darunavir.Approved
TocilizumabThe serum concentration of Darunavir can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Darunavir.Approved, Investigational
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Darunavir.Approved
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Darunavir.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Darunavir.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Darunavir.Approved
ToremifeneThe risk or severity of adverse effects can be increased when Darunavir is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Darunavir.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Darunavir.Approved, Investigational
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Darunavir.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Darunavir.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Darunavir.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Darunavir.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Darunavir.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Darunavir.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Darunavir.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Darunavir.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Darunavir.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Darunavir.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Darunavir.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Darunavir.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Darunavir.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Darunavir.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Darunavir.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Darunavir.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Darunavir.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Darunavir.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Darunavir.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Darunavir.Approved
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Darunavir.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Darunavir.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Darunavir.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Darunavir.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Darunavir.Approved
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Darunavir.Approved, Investigational
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Darunavir.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Darunavir.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Darunavir.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Darunavir.Approved
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Darunavir.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Darunavir.Approved
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Darunavir.Approved, Investigational
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Darunavir.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Darunavir.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Darunavir.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Darunavir.Approved
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Darunavir.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Darunavir.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Darunavir.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Darunavir.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Darunavir.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Darunavir.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Darunavir.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Darunavir.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Darunavir.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Darunavir.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Darunavir.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Darunavir.Approved, Investigational
Food Interactions
  • Take with food - better absorption (+30%).
References
Synthesis Reference

DrugSyn.org

US05158713
General References
  1. Back D, Sekar V, Hoetelmans RM: Darunavir: pharmacokinetics and drug interactions. Antivir Ther. 2008;13(1):1-13. [PubMed:18389894 ]
  2. Tremblay CL: Combating HIV resistance - focus on darunavir. Ther Clin Risk Manag. 2008 Aug;4(4):759-66. [PubMed:19209258 ]
  3. Koh Y, Matsumi S, Das D, Amano M, Davis DA, Li J, Leschenko S, Baldridge A, Shioda T, Yarchoan R, Ghosh AK, Mitsuya H: Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. J Biol Chem. 2007 Sep 28;282(39):28709-20. Epub 2007 Jul 17. [PubMed:17635930 ]
  4. Kovalevsky AY, Tie Y, Liu F, Boross PI, Wang YF, Leshchenko S, Ghosh AK, Harrison RW, Weber IT: Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. J Med Chem. 2006 Feb 23;49(4):1379-87. [PubMed:16480273 ]
  5. De Meyer S, Azijn H, Surleraux D, Jochmans D, Tahri A, Pauwels R, Wigerinck P, de Bethune MP: TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother. 2005 Jun;49(6):2314-21. [PubMed:15917527 ]
  6. Link [Link]
External Links
ATC CodesJ05AE10J05AR14
AHFS Codes
  • 08:18.08.08
PDB EntriesNot Available
FDA labelDownload (281 KB)
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9636
Blood Brain Barrier-0.5518
Caco-2 permeable+0.7274
P-glycoprotein substrateSubstrate0.7464
P-glycoprotein inhibitor IInhibitor0.7588
P-glycoprotein inhibitor IINon-inhibitor0.8683
Renal organic cation transporterNon-inhibitor0.8847
CYP450 2C9 substrateNon-substrate0.5747
CYP450 2D6 substrateSubstrate0.6809
CYP450 3A4 substrateSubstrate0.6496
CYP450 1A2 substrateNon-inhibitor0.7328
CYP450 2C9 inhibitorNon-inhibitor0.6999
CYP450 2D6 inhibitorNon-inhibitor0.8784
CYP450 2C19 inhibitorNon-inhibitor0.6587
CYP450 3A4 inhibitorNon-inhibitor0.5076
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7132
Ames testNon AMES toxic0.5933
CarcinogenicityNon-carcinogens0.7991
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.5482 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9824
hERG inhibition (predictor II)Non-inhibitor0.857
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
TabletOral400 mg
TabletOral
Tablet, film coatedOral
SuspensionOral100 mg
SuspensionOral100 mg/ml
TabletOral150 mg
TabletOral300 mg
TabletOral600 mg
TabletOral75 mg
TabletOral800 mg
Tablet, film coatedOral150 mg
Tablet, film coatedOral150 mg/1
Tablet, film coatedOral300 mg
Tablet, film coatedOral400 mg/1
Tablet, film coatedOral400 mg
Tablet, film coatedOral600 mg
Tablet, film coatedOral600 mg/1
Tablet, film coatedOral75 mg/1
Tablet, film coatedOral75 mg
Tablet, film coatedOral800 mg
Tablet, film coatedOral800 mg/1
Prices
Unit descriptionCostUnit
Prezista 600 mg tablet25.75USD tablet
Prezista 400 mg tablet18.74USD tablet
Prezista 300 mg tablet16.2USD tablet
Prezista 150 mg tablet4.59USD tablet
Prezista 75 mg tablet2.3USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2224738 No2002-08-272016-06-28Canada
CA2469343 No2008-05-132022-12-12Canada
US5843946 Yes1996-06-012016-06-01Us
US6037157 Yes1996-12-262016-12-26Us
US6335460 No1992-08-252012-08-25Us
US6703403 Yes1996-12-262016-12-26Us
US7470506 Yes1999-12-232019-12-23Us
US7700645 Yes2007-06-262027-06-26Us
US8148374 No2009-09-032029-09-03Us
US8518987 Yes2004-08-162024-08-16Us
US8597876 Yes1999-12-232019-12-23Us
USRE42889 Yes1997-04-192017-04-19Us
USRE43596 Yes1997-11-092017-11-09Us
USRE43802 Yes1997-04-192017-04-19Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityApproximately 0.15 mg/mL at 20 °C as ethanolate saltNot Available
logP1.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0668 mg/mLALOGPS
logP1.76ALOGPS
logP2.82ChemAxon
logS-3.9ALOGPS
pKa (Strongest Acidic)13.59ChemAxon
pKa (Strongest Basic)2.39ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area140.42 Å2ChemAxon
Rotatable Bond Count11ChemAxon
Refractivity142.34 m3·mol-1ChemAxon
Polarizability57.24 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentAminobenzenesulfonamides
Alternative Parents
Substituents
  • Phenylbutylamine
  • Aminobenzenesulfonamide
  • Sulfonylaniline
  • Amphetamine or derivatives
  • Substituted aniline
  • Furofuran
  • Aniline
  • Primary aromatic amine
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Oxolane
  • Secondary alcohol
  • Oxacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Acetal
  • Hydrocarbon derivative
  • Primary amine
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human immunodeficiency virus 1
Pharmacological action
yes
Actions
inhibitor
General Function:
Aspartic-type endopeptidase activity
Specific Function:
Not Available
Gene Name:
pol
Uniprot ID:
Q72874
Molecular Weight:
10778.7 Da
References
  1. Dierynck I, De Wit M, Gustin E, Keuleers I, Vandersmissen J, Hallenberger S, Hertogs K: Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier. J Virol. 2007 Dec;81(24):13845-51. Epub 2007 Oct 10. [PubMed:17928344 ]
  2. Ghosh AK, Dawson ZL, Mitsuya H: Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV. Bioorg Med Chem. 2007 Dec 15;15(24):7576-80. Epub 2007 Sep 14. [PubMed:17900913 ]
  3. Wang YF, Tie Y, Boross PI, Tozser J, Ghosh AK, Harrison RW, Weber IT: Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. J Med Chem. 2007 Sep 6;50(18):4509-15. Epub 2007 Aug 16. [PubMed:17696515 ]
  4. McKeage K, Perry CM, Keam SJ: Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503. doi: 10.2165/00003495-200969040-00007. [PubMed:19323590 ]
  5. Tremblay CL: Combating HIV resistance - focus on darunavir. Ther Clin Risk Manag. 2008 Aug;4(4):759-66. [PubMed:19209258 ]
  6. Kovalevsky AY, Tie Y, Liu F, Boross PI, Wang YF, Leshchenko S, Ghosh AK, Harrison RW, Weber IT: Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. J Med Chem. 2006 Feb 23;49(4):1379-87. [PubMed:16480273 ]
  7. De Meyer S, Azijn H, Surleraux D, Jochmans D, Tahri A, Pauwels R, Wigerinck P, de Bethune MP: TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother. 2005 Jun;49(6):2314-21. [PubMed:15917527 ]
  8. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. McKeage K, Perry CM, Keam SJ: Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503. doi: 10.2165/00003495-200969040-00007. [PubMed:19323590 ]
  2. Tremblay CL: Combating HIV resistance - focus on darunavir. Ther Clin Risk Manag. 2008 Aug;4(4):759-66. [PubMed:19209258 ]
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Drug created on May 16, 2007 11:43 / Updated on December 07, 2016 03:54