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Identification
NameIndinavir
Accession NumberDB00224  (APRD00069)
TypeSmall Molecule
GroupsApproved
DescriptionA potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Structure
Thumb
Synonyms
(1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide
Indinavir anhydrous
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
CrixivanCapsule200 mgOralMerck Sharp & Dohme Ltd1996-10-04Not applicableEu
CrixivanCapsule400 mg/1OralSTAT Rx USA LLC1996-03-13Not applicableUs
CrixivanCapsule400 mg/1OralMerck Sharp & Dohme Corp.1996-03-13Not applicableUs
CrixivanCapsule200 mgOralMerck Canada Inc1996-09-262014-09-19Canada
CrixivanCapsule400 mgOralMerck Sharp & Dohme Ltd1996-10-04Not applicableEu
CrixivanCapsule400 mg/1OralRebel Distributors Corp1996-03-13Not applicableUs
CrixivanCapsule300 mgOralMerck Canada IncNot applicableNot applicableCanada
CrixivanCapsule200 mgOralMerck Sharp & Dohme Ltd1996-10-04Not applicableEu
CrixivanCapsule400 mgOralMerck Sharp & Dohme Ltd1996-10-04Not applicableEu
CrixivanCapsule400 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
CrixivanCapsule400 mgOralMerck Canada Inc1996-09-302016-11-01Canada
CrixivanCapsule200 mgOralMerck Sharp & Dohme Ltd1996-10-04Not applicableEu
CrixivanCapsule200 mg/1OralMerck Sharp & Dohme Corp.1996-03-13Not applicableUs
CrixivanCapsule400 mg/1OralAvera Mc Kennan Hospital2015-03-01Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Indinavir monohydrate
180683-37-8
Thumb
  • InChI Key: XTYSXGHMTNTKFH-BDEHJDMKSA-N
  • Monoisotopic Mass: 631.373369698
  • Average Mass: 631.818
DBSALT001802
Indinavir sulfate
157810-81-6
Thumb
  • InChI Key: NUBQKPWHXMGDLP-BDEHJDMKSA-N
  • Monoisotopic Mass: 711.330184259
  • Average Mass: 711.868
DBSALT000338
Categories
UNII9MG78X43ZT
CAS number150378-17-9
WeightAverage: 613.7895
Monoisotopic: 613.362805017
Chemical FormulaC36H47N5O4
InChI KeyCBVCZFGXHXORBI-PXQQMZJSSA-N
InChI
InChI=1S/C36H47N5O4/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45)/t28-,29+,31+,32-,33+/m1/s1
IUPAC Name
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
SMILES
CC(C)(C)NC(=O)[C@@H]1CN(CC2=CN=CC=C2)CCN1C[C@@H](O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]1[[email protected]](O)CC2=CC=CC=C12
Pharmacology
IndicationIndinavir is an antiretroviral drug for the treatment of HIV infection.
Structured Indications
PharmacodynamicsIndinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Indinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Mechanism of actionIndinavir inhibits the HIV viral protease enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
TargetKindPharmacological actionActionsOrganismUniProt ID
Pol polyproteinProteinyes
inhibitor
Human immunodeficiency virus 1Q72874 details
Related Articles
AbsorptionRapidly absorbed
Volume of distributionNot Available
Protein binding60%
Metabolism

Hepatic. Seven metabolites have been identified, one glucuronide conjugate and six oxidative metabolites. In vitro studies indicate that cytochrome P-450 3A4 (CYP3A4) is the major enzyme responsible for formation of the oxidative metabolites.

SubstrateEnzymesProduct
Indinavir
Metabolite M6Details
Route of eliminationLess than 20% of indinavir is excreted unchanged in the urine.
Half life1.8 (± 0.4) hours
ClearanceNot Available
ToxicitySymptoms of overdose include myocardial infarction and angina pectoris.
Affected organisms
  • Human Immunodeficiency Virus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Indinavir.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Indinavir.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Indinavir.Experimental, Illicit
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Indinavir.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Indinavir.Experimental, Illicit
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Indinavir.Approved, Investigational
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Indinavir.Approved
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Indinavir.Approved, Investigational
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Indinavir.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Indinavir.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Indinavir.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Indinavir.Approved
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Indinavir.Withdrawn
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Indinavir.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with Indinavir.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Indinavir.Approved
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Indinavir.Approved
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Indinavir.Experimental
AjmalineThe metabolism of Ajmaline can be decreased when combined with Indinavir.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Indinavir.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Indinavir.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Indinavir.Experimental
AlectinibThe serum concentration of Indinavir can be increased when it is combined with Alectinib.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Indinavir.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Indinavir.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Indinavir.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Indinavir.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Indinavir.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Indinavir.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Indinavir.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Indinavir.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Indinavir.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Indinavir.Approved, Withdrawn
AmantadineThe serum concentration of Indinavir can be increased when it is combined with Amantadine.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Indinavir.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Indinavir.Approved
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Indinavir.Experimental
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Indinavir.Approved
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Indinavir.Illicit, Withdrawn
Aminohippuric acidThe serum concentration of Indinavir can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Indinavir.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Indinavir.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Indinavir.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Indinavir.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Indinavir.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Indinavir.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Indinavir.Approved, Vet Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Indinavir.Approved, Illicit
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Indinavir.Approved
AmsacrineThe serum concentration of Indinavir can be increased when it is combined with Amsacrine.Approved
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Indinavir.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Indinavir.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Indinavir.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Indinavir.Approved, Investigational
AprepitantThe serum concentration of Indinavir can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Indinavir.Approved
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Indinavir.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Indinavir.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Indinavir.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Indinavir.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Indinavir.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Indinavir.Approved
AsenapineThe serum concentration of Indinavir can be decreased when it is combined with Asenapine.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Indinavir.Approved, Withdrawn
AtazanavirThe risk or severity of adverse effects can be increased when Atazanavir is combined with Indinavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Indinavir.Approved
AtomoxetineThe metabolism of Indinavir can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Indinavir.Approved
AtovaquoneThe serum concentration of Indinavir can be decreased when it is combined with Atovaquone.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Indinavir.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Indinavir.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Indinavir.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Indinavir.Approved
BalaglitazoneThe therapeutic efficacy of Balaglitazone can be decreased when used in combination with Indinavir.Investigational
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Indinavir.Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Indinavir.Approved
BeclomethasoneThe serum concentration of Beclomethasone can be increased when it is combined with Indinavir.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Indinavir.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Indinavir.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Indinavir.Approved
BenzocaineThe serum concentration of Indinavir can be increased when it is combined with Benzocaine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Indinavir.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Indinavir.Approved
BepridilThe serum concentration of Indinavir can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Indinavir.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Indinavir.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Indinavir.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Indinavir.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Indinavir.Approved
BiperidenThe serum concentration of Indinavir can be increased when it is combined with Biperiden.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Indinavir.Approved
BoceprevirThe serum concentration of Indinavir can be decreased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Indinavir.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Indinavir.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Indinavir.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Indinavir.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Indinavir.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Indinavir.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Indinavir.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Indinavir.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Indinavir.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Indinavir.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Indinavir.Approved
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Indinavir.Withdrawn
BufuralolThe metabolism of Bufuralol can be decreased when combined with Indinavir.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Indinavir.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Indinavir.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Indinavir.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Indinavir.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Indinavir.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Indinavir.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Indinavir.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Indinavir.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Indinavir.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Indinavir.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Indinavir.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Indinavir.Approved
CandesartanThe serum concentration of Indinavir can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Indinavir can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Indinavir can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Indinavir.Approved
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Indinavir.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Indinavir.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Indinavir.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Indinavir.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Indinavir.Approved, Investigational
CaspofunginThe serum concentration of Indinavir can be increased when it is combined with Caspofungin.Approved
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Indinavir.Experimental
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Indinavir.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Indinavir.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Indinavir.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Indinavir.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Indinavir.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Indinavir.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Indinavir.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Indinavir.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Indinavir.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Indinavir.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Indinavir.Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Indinavir.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Indinavir.Approved, Vet Approved
ChlorpropamideThe serum concentration of Indinavir can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Indinavir can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Indinavir.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Indinavir.Approved, Nutraceutical
CholesterolThe serum concentration of Indinavir can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Indinavir can be decreased when it is combined with Cholic Acid.Approved
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Indinavir.Approved, Investigational
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Indinavir.Experimental
CilazaprilThe serum concentration of Indinavir can be increased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Indinavir.Approved
CimetidineThe serum concentration of Indinavir can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Indinavir.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Indinavir.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Indinavir.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Indinavir.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Indinavir.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Indinavir.Approved
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Indinavir.Approved
ClemastineThe metabolism of Indinavir can be decreased when combined with Clemastine.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Indinavir.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Indinavir.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Indinavir.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Indinavir.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Indinavir.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Indinavir.Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Indinavir.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Indinavir.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Indinavir.Investigational
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Indinavir.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Indinavir.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Indinavir.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Indinavir.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Indinavir resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Indinavir.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Indinavir.Approved, Illicit
ClotrimazoleThe metabolism of Indinavir can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Indinavir.Approved
CobicistatThe metabolism of Indinavir can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Indinavir.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Indinavir.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Indinavir.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Indinavir.Approved
ColforsinThe serum concentration of Indinavir can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Indinavir.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Indinavir.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Indinavir.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Indinavir.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Indinavir.Approved
CyclophosphamideThe risk or severity of adverse effects can be increased when Indinavir is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Indinavir.Approved, Investigational, Vet Approved
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Indinavir.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Indinavir.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Indinavir.Approved
DabrafenibThe serum concentration of Indinavir can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Indinavir.Approved
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Indinavir.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Indinavir.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Indinavir.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Indinavir.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Indinavir.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Indinavir.Approved, Investigational
DarunavirThe metabolism of Darunavir can be decreased when combined with Indinavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Indinavir.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Indinavir.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Indinavir.Approved
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Indinavir.Approved
DeferasiroxThe serum concentration of Indinavir can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Indinavir.Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Indinavir.Approved
DeoxyspergualinThe therapeutic efficacy of Deoxyspergualin can be decreased when used in combination with Indinavir.Investigational
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Indinavir.Approved
DesloratadineThe serum concentration of Indinavir can be increased when it is combined with Desloratadine.Approved, Investigational
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Indinavir.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Indinavir.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Indinavir.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Indinavir.Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Indinavir.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Indinavir.Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Indinavir.Approved, Illicit, Withdrawn
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Indinavir.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Indinavir.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Indinavir.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Indinavir.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Indinavir.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Indinavir.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Indinavir.Approved
DidanosineThe serum concentration of Indinavir can be decreased when it is combined with Didanosine.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Indinavir.Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Indinavir.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Indinavir.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Indinavir.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Indinavir.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Indinavir.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Indinavir.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Indinavir.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Indinavir.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Indinavir.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Indinavir.Illicit
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Indinavir.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Indinavir.Approved
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Indinavir.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Indinavir.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Indinavir.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Indinavir.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Indinavir.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Indinavir.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Indinavir.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Indinavir.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Indinavir.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Indinavir.Approved
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Indinavir.Approved
DoxazosinThe serum concentration of Indinavir can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Indinavir can be decreased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Indinavir.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Indinavir.Approved, Investigational
DoxycyclineThe metabolism of Indinavir can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Indinavir.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Indinavir.Approved
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Indinavir.Approved
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Indinavir.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Indinavir.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Indinavir.Approved, Investigational
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Indinavir.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Indinavir.Approved
EfavirenzThe serum concentration of Indinavir can be decreased when it is combined with Efavirenz.Approved, Investigational
ElbasvirThe serum concentration of Indinavir can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Indinavir.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Indinavir.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Indinavir.Approved
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Indinavir.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Indinavir.Approved, Vet Approved
EncainideThe metabolism of Encainide can be decreased when combined with Indinavir.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Indinavir.Investigational
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Indinavir.Approved, Investigational
EnzalutamideThe serum concentration of Indinavir can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Indinavir can be decreased when it is combined with Epinastine.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Indinavir.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Indinavir.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Indinavir.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Indinavir.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Indinavir.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Indinavir.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Indinavir.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Indinavir.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Indinavir.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Indinavir.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Indinavir.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Indinavir can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Indinavir.Investigational
EsomeprazoleThe serum concentration of Indinavir can be decreased when it is combined with Esomeprazole.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Indinavir.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Indinavir.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Indinavir.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Indinavir.Approved
EstriolThe serum concentration of Estriol can be decreased when it is combined with Indinavir.Approved, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Indinavir.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Indinavir.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Indinavir.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Indinavir.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Indinavir.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Indinavir.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Indinavir.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Indinavir.Approved, Illicit
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Indinavir.Approved
EtodolacThe metabolism of Etodolac can be decreased when combined with Indinavir.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Indinavir.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Indinavir.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Indinavir.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Indinavir.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Indinavir.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Indinavir.Approved, Investigational
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Indinavir.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Indinavir.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Indinavir.Approved
FamotidineThe serum concentration of Indinavir can be decreased when it is combined with Famotidine.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Indinavir.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Indinavir.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Indinavir.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Indinavir.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Indinavir.Approved
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Indinavir.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Indinavir.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Indinavir.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Indinavir.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Indinavir.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Indinavir.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Indinavir.Investigational
FluconazoleThe metabolism of Indinavir can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Indinavir.Approved
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Indinavir.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Indinavir.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Indinavir.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Indinavir.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Indinavir.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Indinavir.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Indinavir.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Indinavir.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Indinavir.Approved, Vet Approved
FlupentixolThe serum concentration of Indinavir can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Indinavir can be increased when it is combined with Fluphenazine.Approved
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Indinavir.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Indinavir.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Indinavir.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Indinavir.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Indinavir.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Indinavir.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Indinavir.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Indinavir.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Indinavir.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Indinavir.Approved
FluvoxamineThe metabolism of Indinavir can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Indinavir.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be decreased when combined with Indinavir.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Indinavir.Approved
FosaprepitantThe serum concentration of Indinavir can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Indinavir can be increased when combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Indinavir.Approved, Investigational
Fusidic AcidThe serum concentration of Indinavir can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Indinavir.Approved
GarlicThe serum concentration of Indinavir can be decreased when it is combined with Garlic.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Indinavir.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Indinavir.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Indinavir.Approved
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Indinavir.Approved
GenisteinThe serum concentration of Indinavir can be increased when it is combined with Genistein.Investigational
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Indinavir.Withdrawn
GliclazideThe metabolism of Gliclazide can be decreased when combined with Indinavir.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Indinavir.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Indinavir.Approved
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Indinavir.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Indinavir.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Indinavir.Approved
GlycerolThe serum concentration of Indinavir can be increased when it is combined with Glycerol.Experimental
Gramicidin DThe serum concentration of Indinavir can be increased when it is combined with Gramicidin D.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Indinavir.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Indinavir.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Indinavir.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Indinavir.Approved, Investigational
GusperimusThe therapeutic efficacy of Gusperimus can be decreased when used in combination with Indinavir.Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Indinavir.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Indinavir.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Indinavir.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Indinavir.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Indinavir.Withdrawn
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Indinavir.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Indinavir.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Indinavir.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Indinavir.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Indinavir.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Indinavir.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Indinavir.Approved
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Indinavir.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Indinavir.Approved
IdelalisibThe serum concentration of Indinavir can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Indinavir resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Indinavir.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Indinavir.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Indinavir.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Indinavir.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Indinavir.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Indinavir.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Indinavir.Investigational
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Indinavir.Approved, Investigational
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Indinavir.Approved
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Indinavir.Approved
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Indinavir.Approved
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Indinavir.Approved
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Indinavir.Approved
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Indinavir.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Indinavir.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Indinavir.Approved, Investigational
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Indinavir.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Indinavir.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Indinavir.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Indinavir.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Indinavir.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Indinavir.Investigational
ItraconazoleThe serum concentration of Indinavir can be increased when it is combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Indinavir.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Indinavir.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Indinavir.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Indinavir.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Indinavir.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Indinavir.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Indinavir.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Indinavir.Approved
KetoconazoleThe serum concentration of Indinavir can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Indinavir.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Indinavir.Approved, Vet Approved
LabetalolThe metabolism of Labetalol can be decreased when combined with Indinavir.Approved
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Indinavir.Approved
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Indinavir.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Indinavir.Approved, Investigational
LansoprazoleThe serum concentration of Indinavir can be decreased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Indinavir.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Indinavir.Investigational
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Indinavir.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Indinavir.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Indinavir.Approved
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Indinavir.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Indinavir.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Indinavir.Approved
LetrozoleThe metabolism of Letrozole can be decreased when combined with Indinavir.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Indinavir.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Indinavir.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Indinavir.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Indinavir.Approved
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Indinavir.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Indinavir.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Indinavir.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Indinavir.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Indinavir.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Indinavir.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Indinavir.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Indinavir.Approved
LiothyronineThe serum concentration of Indinavir can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Indinavir can be decreased when it is combined with Liotrix.Approved
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Indinavir.Approved
LisinoprilThe serum concentration of Indinavir can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Indinavir.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Indinavir.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Indinavir.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Indinavir.Approved
LopinavirThe metabolism of Lopinavir can be decreased when combined with Indinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Indinavir.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Indinavir.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Indinavir.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Indinavir.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Indinavir.Approved, Investigational
LuliconazoleThe serum concentration of Indinavir can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Indinavir can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Indinavir.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Indinavir.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Indinavir.Approved
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Indinavir.Approved
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Indinavir.Approved, Investigational
MaprotilineThe serum concentration of Indinavir can be increased when it is combined with Maprotiline.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Indinavir.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Indinavir.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Indinavir.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Indinavir.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Indinavir.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Indinavir.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Indinavir.Approved
Megestrol acetateThe serum concentration of Indinavir can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Indinavir.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Indinavir.Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Indinavir.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Indinavir.Investigational, Withdrawn
MeprobamateThe serum concentration of Indinavir can be increased when it is combined with Meprobamate.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Indinavir.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Indinavir.Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Indinavir.Approved
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Indinavir.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Indinavir.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Indinavir.Experimental
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Indinavir.Approved, Illicit
MethanthelineThe serum concentration of Indinavir can be decreased when it is combined with Methantheline.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Indinavir.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Indinavir.Approved
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Indinavir.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Indinavir.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Indinavir.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Indinavir.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Indinavir.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Indinavir.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Indinavir.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Indinavir.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Indinavir.Approved, Illicit, Withdrawn
MetiamideThe serum concentration of Indinavir can be decreased when it is combined with Metiamide.Experimental
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Indinavir.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Indinavir.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Indinavir.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Indinavir.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Indinavir.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Indinavir.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Indinavir.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Indinavir.Approved, Illicit
MifepristoneThe serum concentration of Indinavir can be increased when it is combined with Mifepristone.Approved, Investigational
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Indinavir.Approved
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Indinavir.Approved
MinaprineThe metabolism of Minaprine can be decreased when combined with Indinavir.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Indinavir.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Indinavir.Approved
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Indinavir.Approved, Investigational
MitomycinThe serum concentration of Indinavir can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Indinavir can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Indinavir.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Indinavir.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Indinavir.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Indinavir.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Indinavir.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Indinavir.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Indinavir.Approved, Investigational
NadololThe serum concentration of Nadolol can be decreased when it is combined with Indinavir.Approved
NafcillinThe serum concentration of Indinavir can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Indinavir.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Indinavir.Approved, Vet Approved
NaltrexoneThe serum concentration of Indinavir can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Indinavir.Approved, Vet Approved
NaringeninThe serum concentration of Indinavir can be increased when it is combined with Naringenin.Experimental
NateglinideThe metabolism of Nateglinide can be decreased when combined with Indinavir.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Indinavir.Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Indinavir.Approved, Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Indinavir.Approved, Withdrawn
NelfinavirThe metabolism of Indinavir can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Indinavir can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Indinavir can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Indinavir can be decreased when it is combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Indinavir.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Indinavir.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Indinavir.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Indinavir.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Indinavir.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Indinavir.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Indinavir.Approved
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Indinavir.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Indinavir.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Indinavir.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Indinavir.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Indinavir.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Indinavir.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Indinavir.Approved, Vet Approved
NizatidineThe serum concentration of Indinavir can be decreased when it is combined with Nizatidine.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Indinavir.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Indinavir.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Indinavir.Approved
OlanzapineThe serum concentration of Indinavir can be decreased when it is combined with Olanzapine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Indinavir.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Indinavir.Investigational
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Indinavir.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Indinavir.Approved
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Indinavir.Approved
OmeprazoleThe serum concentration of Indinavir can be decreased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Indinavir.Approved
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Indinavir.Investigational
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Indinavir.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Indinavir.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Indinavir.Approved
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Indinavir.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Indinavir.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Indinavir.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Indinavir.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Indinavir is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Indinavir.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Indinavir can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Indinavir.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Indinavir.Approved
Palmitic AcidThe serum concentration of Indinavir can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Indinavir.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Indinavir.Approved, Investigational
PantoprazoleThe serum concentration of Indinavir can be decreased when it is combined with Pantoprazole.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Indinavir.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Indinavir.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Indinavir.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Indinavir.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Indinavir.Approved
ParoxetineThe serum concentration of Indinavir can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Indinavir.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Indinavir.Approved
PentobarbitalThe metabolism of Indinavir can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Indinavir.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Indinavir.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Indinavir.Approved
PerindoprilThe serum concentration of Indinavir can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Indinavir.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Indinavir.Approved
PethidineThe risk or severity of adverse effects can be increased when Indinavir is combined with Pethidine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Indinavir.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Indinavir.Approved, Withdrawn
PhenobarbitalThe metabolism of Indinavir can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Indinavir.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Indinavir.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Indinavir.Approved, Vet Approved
PhenytoinThe metabolism of Indinavir can be increased when combined with Phenytoin.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Indinavir.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Indinavir.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Indinavir.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Indinavir.Withdrawn
PindololThe metabolism of Pindolol can be decreased when combined with Indinavir.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Indinavir.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Indinavir.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Indinavir.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Indinavir.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Indinavir.Approved
Platelet Activating FactorThe serum concentration of Indinavir can be decreased when it is combined with Platelet Activating Factor.Experimental
PodofiloxThe metabolism of Podofilox can be decreased when combined with Indinavir.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Indinavir.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Indinavir.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Indinavir.Approved, Investigational, Vet Approved
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Indinavir.Approved, Investigational
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Indinavir.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Indinavir.Approved, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Indinavir resulting in a loss in efficacy.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Indinavir.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Indinavir.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Indinavir.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Indinavir.Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Indinavir.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Indinavir.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Indinavir.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Indinavir.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Indinavir.Experimental
PrimaquineThe metabolism of Primaquine can be decreased when combined with Indinavir.Approved
PrimidoneThe metabolism of Indinavir can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Indinavir can be increased when it is combined with Probenecid.Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Indinavir.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Indinavir.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Indinavir.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Indinavir.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Indinavir.Approved, Vet Approved
PromethazineThe serum concentration of Indinavir can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Indinavir can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Indinavir.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Indinavir.Approved, Investigational
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Indinavir.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Indinavir.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Indinavir.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Indinavir.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Indinavir.Approved, Illicit
QuercetinThe serum concentration of Indinavir can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Indinavir.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Indinavir.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Indinavir.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Indinavir.Approved
RabeprazoleThe serum concentration of Indinavir can be decreased when it is combined with Rabeprazole.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Indinavir.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Indinavir.Approved, Investigational
RanitidineThe serum concentration of Indinavir can be decreased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Indinavir.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Indinavir.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Indinavir.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Indinavir.Approved, Withdrawn
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Indinavir.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Indinavir.Investigational
ReserpineThe serum concentration of Reserpine can be decreased when it is combined with Indinavir.Approved
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Indinavir.Approved
RifabutinThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Indinavir.Approved
RifampicinThe serum concentration of Indinavir can be decreased when it is combined with Rifampicin.Approved
RifapentineThe metabolism of Indinavir can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Indinavir.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Indinavir.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Indinavir.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Indinavir.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Indinavir.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Indinavir.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Indinavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Indinavir.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Indinavir.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Indinavir.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Indinavir.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Indinavir.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Indinavir.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Indinavir.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Indinavir.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Indinavir.Approved
Roxatidine acetateThe serum concentration of Indinavir can be decreased when it is combined with Roxatidine acetate.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Indinavir.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Indinavir.Approved
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Indinavir.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Indinavir.Approved
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Indinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Indinavir.Approved
ScopolamineThe serum concentration of Indinavir can be increased when it is combined with Scopolamine.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Indinavir.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Indinavir.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Indinavir.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Indinavir.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Indinavir.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Indinavir.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Indinavir.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Indinavir.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Indinavir.Approved
SiltuximabThe serum concentration of Indinavir can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Indinavir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Indinavir.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Indinavir.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Indinavir.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Indinavir.Approved, Investigational, Withdrawn
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Indinavir.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Indinavir.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Indinavir.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Indinavir.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Indinavir.Approved
SparteineThe metabolism of Sparteine can be decreased when combined with Indinavir.Experimental
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Indinavir.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Indinavir.Approved
SpironolactoneThe serum concentration of Indinavir can be increased when it is combined with Spironolactone.Approved
St. John's WortThe metabolism of Indinavir can be increased when combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Indinavir can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Indinavir can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Indinavir can be decreased when it is combined with Streptozocin.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Indinavir.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Indinavir.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Indinavir.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Indinavir.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Indinavir.Approved
SulfisoxazoleThe metabolism of Indinavir can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Indinavir.Approved, Investigational
SumatriptanThe serum concentration of Indinavir can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Indinavir.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Indinavir.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Indinavir.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Indinavir.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Indinavir.Approved
TacrineThe serum concentration of Indinavir can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Indinavir.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Indinavir.Approved, Investigational
TAK-390MRThe serum concentration of Indinavir can be decreased when it is combined with TAK-390MR.Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Indinavir resulting in a loss in efficacy.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Indinavir.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Indinavir.Approved
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Indinavir.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Indinavir.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Indinavir.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Indinavir.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Indinavir.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Indinavir.Investigational, Withdrawn
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Indinavir.Approved
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Indinavir.Approved
TelmisartanThe serum concentration of Indinavir can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Indinavir.Approved
TemsirolimusThe risk or severity of adverse effects can be increased when Indinavir is combined with Temsirolimus.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Indinavir.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Indinavir.Approved
TerazosinThe serum concentration of Indinavir can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Indinavir.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Indinavir.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Indinavir.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Indinavir.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Indinavir.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Indinavir.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Indinavir.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Indinavir.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Indinavir.Approved, Vet Approved
ThiazolidinedioneThe therapeutic efficacy of Thiazolidinedione can be decreased when used in combination with Indinavir.Investigational
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Indinavir.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Indinavir.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Indinavir.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Indinavir.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Indinavir resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Indinavir.Approved
TimololThe serum concentration of Timolol can be decreased when it is combined with Indinavir.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Indinavir.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Indinavir.Approved
TipranavirThe serum concentration of Indinavir can be decreased when it is combined with Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Indinavir.Approved
TocilizumabThe serum concentration of Indinavir can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Indinavir.Approved, Investigational
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Indinavir.Approved
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Indinavir.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Indinavir.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Indinavir.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Indinavir.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Indinavir.Approved
ToremifeneThe risk or severity of adverse effects can be increased when Indinavir is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Indinavir.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Indinavir.Approved, Investigational
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Indinavir.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Indinavir.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Indinavir.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Indinavir.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Indinavir.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Indinavir.Approved
TrifluoperazineThe serum concentration of Indinavir can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Indinavir can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Indinavir.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Indinavir.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Indinavir.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Indinavir.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Indinavir.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Indinavir.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Indinavir.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Indinavir.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Indinavir.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Indinavir.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Indinavir.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Indinavir.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Indinavir.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Indinavir.Approved
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Indinavir.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Indinavir.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Indinavir.Approved
VenlafaxineThe serum concentration of Indinavir can be decreased when it is combined with Venlafaxine.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Indinavir.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Indinavir.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Indinavir.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Indinavir.Approved
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Indinavir.Approved, Investigational
VinblastineThe metabolism of Vinblastine can be decreased when combined with Indinavir.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Indinavir.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Indinavir.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Indinavir.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Indinavir.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Indinavir.Approved
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Indinavir.Approved, Investigational
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Indinavir.Approved
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Indinavir.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Indinavir.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Indinavir.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Indinavir.Approved, Investigational, Withdrawn
YohimbineThe metabolism of Yohimbine can be decreased when combined with Indinavir.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Indinavir.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Indinavir.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Indinavir.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Indinavir.Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Indinavir.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Indinavir.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Indinavir can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Indinavir.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Indinavir.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Indinavir.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Indinavir.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Indinavir.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Indinavir.Approved, Investigational
Food Interactions
  • Avoid excessive or chronic alcohol use.
  • Avoid taking with grapefruit juice
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Take with a full glass of water.
References
Synthesis Reference

DrugSyn.org

US5413999
General ReferencesNot Available
External Links
ATC CodesJ05AE02
AHFS Codes
  • 08:18.08.08
PDB Entries
FDA labelDownload (671 KB)
MSDSDownload (57 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.821
Blood Brain Barrier-0.9923
Caco-2 permeable-0.8183
P-glycoprotein substrateSubstrate0.8899
P-glycoprotein inhibitor IInhibitor0.7987
P-glycoprotein inhibitor IINon-inhibitor0.5819
Renal organic cation transporterNon-inhibitor0.8501
CYP450 2C9 substrateNon-substrate0.7816
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7831
CYP450 1A2 substrateNon-inhibitor0.9057
CYP450 2C9 inhibitorNon-inhibitor0.6278
CYP450 2D6 inhibitorNon-inhibitor0.7476
CYP450 2C19 inhibitorNon-inhibitor0.6264
CYP450 3A4 inhibitorInhibitor0.6525
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7808
Ames testNon AMES toxic0.8629
CarcinogenicityNon-carcinogens0.887
BiodegradationNot ready biodegradable0.9951
Rat acute toxicity2.1844 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9557
hERG inhibition (predictor II)Inhibitor0.7265
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Merck sharp and dohme corp
Packagers
Dosage forms
FormRouteStrength
CapsuleOral200 mg/1
CapsuleOral200 mg
CapsuleOral300 mg
CapsuleOral400 mg/1
CapsuleOral400 mg
Prices
Unit descriptionCostUnit
Crixivan 360 200 mg capsule Bottle570.02USD bottle
Crixivan 400 mg capsule2.86USD each
Crixivan 333 mg capsule2.54USD each
Crixivan 200 mg capsule1.52USD each
Crixivan 100 mg capsule0.76USD each
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2081970 No1997-07-082012-11-02Canada
US5413999 No1995-05-092012-05-09Us
US6645961 No1998-03-042018-03-04Us
US6689761 No2001-02-102021-02-10Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point167.5-168 °CNot Available
water solubility0.015 mg/mlNot Available
logP2.9Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0482 mg/mLALOGPS
logP3.26ALOGPS
logP2.81ChemAxon
logS-4.1ALOGPS
pKa (Strongest Acidic)13.19ChemAxon
pKa (Strongest Basic)7.37ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area118.03 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity175.89 m3·mol-1ChemAxon
Polarizability68.63 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • Phenylpropylamine
  • Piperazine-2-carboxamide
  • Indane
  • Aralkylamine
  • N-alkylpiperazine
  • Fatty acyl
  • Benzenoid
  • Pyridine
  • Piperazine
  • N-acyl-amine
  • Fatty amide
  • 1,4-diazinane
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Carboxamide group
  • 1,2-aminoalcohol
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human immunodeficiency virus 1
Pharmacological action
yes
Actions
inhibitor
General Function:
Aspartic-type endopeptidase activity
Specific Function:
Not Available
Gene Name:
pol
Uniprot ID:
Q72874
Molecular Weight:
10778.7 Da
References
  1. Wittayanarakul K, Hannongbua S, Feig M: Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 2008 Apr 15;29(5):673-85. [PubMed:17849388 ]
  2. Dandache S, Sevigny G, Yelle J, Stranix BR, Parkin N, Schapiro JM, Wainberg MA, Wu JJ: In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2007 Nov;51(11):4036-43. Epub 2007 Jul 16. [PubMed:17638694 ]
  3. Hoetelmans RM, Meenhorst PL, Mulder JW, Burger DM, Koks CH, Beijnen JH: Clinical pharmacology of HIV protease inhibitors: focus on saquinavir, indinavir, and ritonavir. Pharm World Sci. 1997 Aug;19(4):159-75. [PubMed:9297727 ]
  4. Stein DS, Fish DG, Bilello JA, Preston SL, Martineau GL, Drusano GL: A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS. 1996 May;10(5):485-92. [PubMed:8724039 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Perloff MD, von Moltke LL, Fahey JM, Daily JP, Greenblatt DJ: Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture. AIDS. 2000 Jun 16;14(9):1287-9. [PubMed:10894301 ]
  2. Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. [PubMed:10820137 ]
  3. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674 ]
  4. Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH: In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. J Pharmacol Exp Ther. 2001 Mar;296(3):723-35. [PubMed:11181899 ]
  5. Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR: The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998 Jan 15;101(2):289-94. [PubMed:9435299 ]
  6. Hochman JH, Chiba M, Nishime J, Yamazaki M, Lin JH: Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4. J Pharmacol Exp Ther. 2000 Jan;292(1):310-8. [PubMed:10604964 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM: Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos. 2000 Mar;28(3):329-34. [PubMed:10681378 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Olson DP, Scadden DT, D'Aquila RT, De Pasquale MP: The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1). AIDS. 2002 Sep 6;16(13):1743-7. [PubMed:12218384 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. [PubMed:12490595 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Huisman MT, Smit JW, Crommentuyn KM, Zelcer N, Wiltshire HR, Beijnen JH, Schinkel AH: Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. AIDS. 2002 Nov 22;16(17):2295-301. [PubMed:12441801 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on December 07, 2016 02:37