Cytochrome P-450 CYP3A4 Inhibitors (strong)

DrugDrug NameDrug Indication
DB00220NelfinavirUsed in combination with other antiviral drugs in the treatment of HIV in both adults and children.
DB00224IndinavirIndinavir is an antiretroviral drug for the treatment of HIV infection.
DB00582VoriconazoleFor the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.
DB00976TelithromycinFor the treatment of Pneumococcal infection, acute sinusitis, acute bacterial tonsillitis, acute bronchitis and bronchiolitis, lower respiratory tract infection and lobar (pneumococcal) pneumonia.
DB01026KetoconazoleFor the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
DB01149NefazodoneFor the treatment of depression.
DB01167ItraconazoleFor the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
DB01211ClarithromycinAn alternative medication for the treatment of acute otitis media caused by H. influenzae, M. catarrhalis, or S. pneumoniae in patients with a history of type I penicillin hypersensitivity. Also for the treatment of pharyngitis and tonsillitis caused by susceptible Streptococcus pyogenes, as well as respiratory tract infections including acute maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis, mild to moderate community-acquired pneuomia, Legionnaires' disease, and pertussis. Other indications include treatment of uncomplicated skin or skin structure infections, helicobacter pylori infection, duodenal ulcer disease, bartonella infections, early Lyme disease, and encephalitis caused by Toxoplasma gondii (in HIV infected patients in conjunction with pyrimethamine). Clarithromycin may also decrease the incidence of cryptosporidiosis, prevent the occurence of α-hemolytic (viridans group) streptococcal endocarditis, as well as serve as a primary prevention for Mycobacterium avium complex (MAC) bacteremia or disseminated infections (in adults, adolescents, and children with advanced HIV infection).
DB01232SaquinavirFor the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.
DB01264DarunavirDarunavir, co-administered with ritonavir, and with other antiretroviral agents, is indicated for the treatment of human immunodeficiency virus (HIV) infection in antiretroviral treatment-experienced adult patients, such as those with HIV-1 strains resistant to more than one protease inhibitor.
DB01263PosaconazoleFor prophylaxis of invasive Aspergillus and Candida infections in patients, 13 years of age and older, who are at high risk of developing these infections due to being severely immunocompromised as a result of procedures such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD), or due to hematologic malignancies with prolonged neutropenia from chemotherapy. Also for the treatment of oropharyngeal candidiasis, including oropharyngeal candidiasis refractory to itraconazole and/or fluconazole. Posaconazole is used as an alternative treatment for invasive aspergillosis, Fusarium infections, and zygomycosis in patients who are intolerant of, or whose disease is refractory to, other antifungals.
DB01601LopinavirIndicated in combination with other antiretroviral agents for the treatment of HIV-infection.
DB05521TelaprevirTelaprevir, when used in combination with [DB00811], [DB00008], and [DB00022] is indicated for use in the treatment of chronic HCV genotype 1 infection in adults [FDA Label].
DB08873BoceprevirBoceprevir, when used in combination with [DB00811], [DB00008], and [DB00022] is indicated for use in the treatment of chronic HCV genotype 1 infection in adults [FDA Label].
DB09054IdelalisibIdelalisib is indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other co-morbidities, while in the treatment of FL and SLL it is intended to be used in patients who have received at least two prior systemic therapies.
DB09065CobicistatCobicistat is a CYP3A inhibitor indicated to increase systemic exposure of atazanavir or darunavir (once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 infection. It is not interchangeable with ritonavir to increase systemic exposure of darunavir 600 mg twice daily, fosamprenavir, saquinavir, or tipranavir due to lack of exposure data. The use of cobicistat is not recommended with darunavir 600 mg twice daily, fosamprenavir, saquinavir or tipranavir. Complex or unknown mechanisms of drug interactions preclude extrapolation of ritonavir drug interactions to certain cobicistat interactions. Cobicistat and ritonavir when administered with either atazanavir or darunavir may result in different drug interactions when used with concomitant medications.
DB09118StiripentolIndicated for use in conjunction with clobazam and valproate as adjunctive therapy of refractory generalized tonic-clonic seizures in patients with severe myoclonic epilepsy in infancy (SMEI, Dravet’s syndrome) whose seizures are not adequately controlled with clobazam and valproate.
DB11672CurcuminNo approved therapeutic indications.
DB00503RitonavirIndicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.
DB00872ConivaptanFor the treatment of euvolemic or hypervolemic hyponatremia (e.g. the syndrome of inappropriate secretion of antidiuretic hormone, or in the setting of hypothyroidism, adrenal insufficiency, pulmonary disorders, etc.) in hospitalized patients.
DB13179TroleandomycinFor the treatment of bacterial infection.
DB01388MibefradilFor the treatment of angina and high blood pressure.
DB00254DoxycyclineDoxycycline is indicated for use in respiratory tract infections caused by Mycoplasma pneumoniae, Haemophilus influenzae, Streptococcus pneumoniae, Legionella spp., or Klebsiella spp. It is also used for prophylaxis of malaria. Doxycycline is indicated for a variety of bacterial infections, from Mycobacterium fortuitum and M. marinum, to susceptible E. coli and Brucella spp. It can be used as an alternative to treating plague, tetanus, Campylobacter fetus
DB00625EfavirenzFor use in combination treatment of HIV infection (AIDS)
DB01072AtazanavirUsed in combination with other antiretroviral agents for the treatment of HIV-1 infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially infectious body fluids of a person known to be infected with HIV when that exposure represents a substantial risk for HIV transmission.
DB00932TipranavirFor combination antiretroviral treatment of HIV-1 infected adult patients with evidence of viral replication, who are highly treatment-experienced or have HIV-1 strains resistant to multiple protease inhibitors.
DB01183NaloxoneFor the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol. It is also indicated for the diagnosis of suspected acute opioid overdose. It may also be used as an adjunctive agent to increase blood pressure in the management of septic shock.
DB00257ClotrimazoleFor the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
DB04868NilotinibFor the potential treatment of various leukemias, including chronic myeloid leukemia (CML).
DB00705DelavirdineFor the treatment of HIV-1 infection in combination with appropriate antiretroviral agents when therapy is warranted
DB00836LoperamideFor the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
DB11730RibociclibKisqali (ribociclib) is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue to replicate uncontrollably.
DB11779DanoprevirNot Available
DB09101ElvitegravirElvitegravir in combination with an HIV protease inhibitor coadministered with ritonavir and with other antiretroviral drug(s) is indicated for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.
DB06595MidostaurinInvestigated for use/treatment in adult patients with high-risk acute myeloid leukemia (AML) who are FLT3 mutation-positive, agressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN), or mast cell leukemia (MCL).
DB00342TerfenadineFor the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
DB00696ErgotamineFor use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called "histaminic cephalalgia".
DB01127EconazoleFor topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
DrugDrug NameTargetType
DB00220NelfinavirSerum albumincarrier
DB00220NelfinavirCytochrome P450 2C19enzyme
DB00220NelfinavirCytochrome P450 3A4enzyme
DB00220NelfinavirCytochrome P450 2B6enzyme
DB00220NelfinavirCytochrome P450 3A5enzyme
DB00220NelfinavirCytochrome P450 3A7enzyme
DB00220NelfinavirCytochrome P450 2D6enzyme
DB00220NelfinavirUDP-glucuronosyltransferase 1-1enzyme
DB00220NelfinavirHIV-1 proteasetarget
DB00220NelfinavirMultidrug resistance protein 1transporter
DB00220NelfinavirSolute carrier family 22 member 1transporter
DB00220NelfinavirSolute carrier organic anion transporter family member 1A2transporter
DB00220NelfinavirATP-binding cassette sub-family G member 2transporter
DB00220NelfinavirSolute carrier organic anion transporter family member 1B1transporter
DB00220NelfinavirSolute carrier organic anion transporter family member 1B3transporter
DB00220NelfinavirSolute carrier organic anion transporter family member 2B1transporter
DB00220NelfinavirBile salt export pumptransporter
DB00224IndinavirCytochrome P450 3A4enzyme
DB00224IndinavirCytochrome P450 3A5enzyme
DB00224IndinavirCytochrome P450 3A7enzyme
DB00224IndinavirCytochrome P450 2D6enzyme
DB00224IndinavirUDP-glucuronosyltransferase 1-1enzyme
DB00224IndinavirHuman immunodeficiency virus type 1 proteasetarget
DB00224IndinavirMultidrug resistance protein 1transporter
DB00224IndinavirSolute carrier family 22 member 1transporter
DB00224IndinavirMultidrug resistance-associated protein 1transporter
DB00224IndinavirSolute carrier organic anion transporter family member 1A2transporter
DB00224IndinavirSolute carrier organic anion transporter family member 1B1transporter
DB00224IndinavirCanalicular multispecific organic anion transporter 1transporter
DB00224IndinavirSolute carrier organic anion transporter family member 2B1transporter
DB00224IndinavirBile salt export pumptransporter
DB00582VoriconazoleCytochrome P450 2C19enzyme
DB00582VoriconazoleCytochrome P450 3A4enzyme
DB00582VoriconazoleCytochrome P450 2C9enzyme
DB00582VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00582VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00582VoriconazoleCytochrome P450 3A5enzyme
DB00582VoriconazoleCytochrome P450 3A7enzyme
DB00582VoriconazoleProstaglandin G/H synthase 1enzyme
DB00582VoriconazoleCytochrome P450 2B6enzyme
DB00582VoriconazoleLanosterol 14-alpha demethylasetarget
DB00976TelithromycinCytochrome P450 3A4enzyme
DB00976TelithromycinCytochrome P450 3A5enzyme
DB00976TelithromycinCytochrome P450 3A7enzyme
DB00976Telithromycin23S rRNAtarget
DB00976TelithromycinSolute carrier organic anion transporter family member 1B1transporter
DB00976TelithromycinSolute carrier organic anion transporter family member 1B3transporter
DB01026KetoconazoleCytochrome P450 3A4enzyme
DB01026KetoconazoleCytochrome P450 2C9enzyme
DB01026KetoconazoleCytochrome P450 2C19enzyme
DB01026KetoconazoleCytochrome P450 3A5enzyme
DB01026KetoconazoleCytochrome P450 1A2enzyme
DB01026KetoconazoleCytochrome P450 2C8enzyme
DB01026KetoconazoleCytochrome P450 1A1enzyme
DB01026KetoconazoleCytochrome P450 2D6enzyme
DB01026KetoconazoleCytochrome P450 3A7enzyme
DB01026KetoconazoleCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01026KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
DB01026KetoconazoleCytochrome P450 1B1enzyme
DB01026KetoconazoleCytochrome P450 26A1enzyme
DB01026KetoconazoleCytochrome P450 2A6enzyme
DB01026KetoconazoleCytochrome P450 2B6enzyme
DB01026KetoconazoleLanosterol 14-alpha demethylaseenzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
DB01026KetoconazoleCytochrome P450 4F12enzyme
DB01026KetoconazoleLeukotriene-B(4) omega-hydroxylase 1enzyme
DB01026KetoconazoleLanosterol 14-alpha demethylasetarget
DB01026KetoconazoleAndrogen receptortarget
DB01026Ketoconazole17-hydroxylasetarget
DB01026KetoconazoleSteroid 21-hydroxylasetarget
DB01026Ketoconazole11-hydroxylasetarget
DB01026KetoconazoleCytochrome P450 19A1target
DB01026KetoconazolePotassium voltage-gated channel subfamily H member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 3target
DB01026KetoconazoleBile salt export pumptransporter
DB01026KetoconazoleMultidrug resistance protein 1transporter
DB01026KetoconazoleSolute carrier organic anion transporter family member 1A2transporter
DB01026KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
DB01149NefazodoneCytochrome P450 3A4enzyme
DB01149NefazodoneCytochrome P450 2D6enzyme
DB01149NefazodoneCYP2B proteinenzyme
DB01149NefazodoneCytochrome P450 3A5enzyme
DB01149NefazodoneCYP3Aenzyme
DB01149Nefazodone5-hydroxytryptamine receptor 2Atarget
DB01149NefazodoneSodium-dependent serotonin transportertarget
DB01149NefazodoneSodium-dependent noradrenaline transportertarget
DB01149NefazodoneAlpha-1A adrenergic receptortarget
DB01149NefazodoneAlpha-1B adrenergic receptortarget
DB01149NefazodoneSodium-dependent dopamine transportertarget
DB01149NefazodoneAlpha-2A adrenergic receptortarget
DB01149Nefazodone5-hydroxytryptamine receptor 1Atarget
DB01149Nefazodone5-hydroxytryptamine receptor 2Ctarget
DB01149NefazodonePotassium voltage-gated channel subfamily H member 2target
DB01149NefazodoneMultidrug resistance protein 1transporter
DB01149NefazodoneSolute carrier organic anion transporter family member 1B3transporter
DB01149NefazodoneSolute carrier organic anion transporter family member 2B1transporter
DB01149NefazodoneBile salt export pumptransporter
DB01167ItraconazoleCytochrome P450 3A4enzyme
DB01167ItraconazoleCytochrome P450 2D6enzyme
DB01167ItraconazoleCytochrome P450 3A5enzyme
DB01167ItraconazoleCytochrome P450 3A7enzyme
DB01167ItraconazoleCytochrome P450 2B6enzyme
DB01167ItraconazoleCytochrome P450 1A1enzyme
DB01167ItraconazoleCytochrome P450 2E1enzyme
DB01167ItraconazoleLanosterol 14-alpha demethylasetarget
DB01167ItraconazoleLanosterol 14-alpha demethylasetarget
DB01167ItraconazoleMultidrug resistance protein 1transporter
DB01167ItraconazoleSolute carrier organic anion transporter family member 2B1transporter
DB01211ClarithromycinCytochrome P450 3A4enzyme
DB01211ClarithromycinCytochrome P450 2C19enzyme
DB01211ClarithromycinCytochrome P450 3A5enzyme
DB01211ClarithromycinCytochrome P450 3A7enzyme
DB01211Clarithromycin50S ribosomal protein L10target
DB01211ClarithromycinPotassium voltage-gated channel subfamily H member 2target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B1target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B3target
DB01211ClarithromycinMultidrug resistance protein 1transporter
DB01211ClarithromycinSolute carrier family 22 member 7transporter
DB01211ClarithromycinBile salt export pumptransporter
DB01232SaquinavirAlpha-1-acid glycoprotein 1carrier
DB01232SaquinavirSerum albumincarrier
DB01232SaquinavirCytochrome P450 3A4enzyme
DB01232SaquinavirCytochrome P450 3A5enzyme
DB01232SaquinavirCytochrome P450 3A7enzyme
DB01232SaquinavirCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01232SaquinavirCytochrome P450 2C8enzyme
DB01232SaquinavirCytochrome P450 2D6enzyme
DB01232SaquinavirHuman immunodeficiency virus type 1 proteasetarget
DB01232SaquinavirMultidrug resistance protein 1transporter
DB01232SaquinavirSolute carrier family 22 member 1transporter
DB01232SaquinavirSolute carrier organic anion transporter family member 1A2transporter
DB01232SaquinavirATP-binding cassette sub-family G member 2transporter
DB01232SaquinavirSolute carrier organic anion transporter family member 1B1transporter
DB01232SaquinavirMultidrug resistance-associated protein 1transporter
DB01232SaquinavirCanalicular multispecific organic anion transporter 1transporter
DB01232SaquinavirSolute carrier organic anion transporter family member 2B1transporter
DB01232SaquinavirBile salt export pumptransporter
DB01264DarunavirCytochrome P450 3A4enzyme
DB01264DarunavirHuman immunodeficiency virus type 1 proteasetarget
DB01264DarunavirSolute carrier organic anion transporter family member 1B1transporter
DB01263PosaconazoleCytochrome P450 3A4enzyme
DB01263PosaconazoleLanosterol 14-alpha demethylasetarget
DB01263PosaconazoleMultidrug resistance protein 1transporter
DB01601LopinavirCytochrome P450 3A4enzyme
DB01601LopinavirCytochrome P450 2D6enzyme
DB01601LopinavirCytochrome P450 2C19enzyme
DB01601LopinavirCytochrome P450 2B6enzyme
DB01601LopinavirCytochrome P450 2C9enzyme
DB01601LopinavirCytochrome P450 2C8enzyme
DB01601LopinavirCYP3Aenzyme
DB01601LopinavirHuman immunodeficiency virus type 1 proteasetarget
DB01601LopinavirMultidrug resistance protein 1transporter
DB01601LopinavirSolute carrier organic anion transporter family member 1B1transporter
DB01601LopinavirSolute carrier organic anion transporter family member 1B3transporter
DB01601LopinavirBile salt export pumptransporter
DB05521TelaprevirSerum albumincarrier
DB05521TelaprevirAlpha-1-acid glycoprotein 1carrier
DB05521TelaprevirCytochrome P450 3A4enzyme
DB05521TelaprevirCytochrome P450 3A5enzyme
DB05521TelaprevirNS3/4A proteintarget
DB05521TelaprevirSolute carrier organic anion transporter family member 1B1target
DB05521TelaprevirSolute carrier organic anion transporter family member 2B1target
DB05521TelaprevirMultidrug resistance protein 1transporter
DB08873BoceprevirCytochrome P450 3A4enzyme
DB08873BoceprevirCytochrome P450 3A5enzyme
DB08873BoceprevirNS3/4A proteintarget
DB08873BoceprevirMultidrug resistance protein 1transporter
DB09054IdelalisibAldehyde oxidaseenzyme
DB09054IdelalisibUDP-glucuronosyltransferase 1A4enzyme
DB09054IdelalisibUDP-glucuronosyltransferase 1A1enzyme
DB09054IdelalisibCytochrome P450 2C8enzyme
DB09054IdelalisibCytochrome P450 2C19enzyme
DB09054IdelalisibCytochrome P450 2B6enzyme
DB09054IdelalisibCytochrome P450 3A4enzyme
DB09054IdelalisibCytochrome P450 3A5enzyme
DB09054IdelalisibCytochrome P450 3A43enzyme
DB09054IdelalisibCytochrome P450 3A7enzyme
DB09054IdelalisibPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (P110δ)target
DB09054IdelalisibATP-binding cassette sub-family G member 2transporter
DB09054IdelalisibMultidrug resistance protein 1transporter
DB09054IdelalisibSolute carrier organic anion transporter family member 1B1transporter
DB09054IdelalisibSolute carrier organic anion transporter family member 1B3transporter
DB09065CobicistatCytochrome P450 2D6enzyme
DB09065CobicistatCytochrome P450 3A4enzyme
DB09065CobicistatCytochrome P450 3A5enzyme
DB09065CobicistatCytochrome P450 3A7enzyme
DB09065CobicistatCytochrome P450 3A43enzyme
DB09065CobicistatMultidrug resistance protein 1transporter
DB09065CobicistatATP-binding cassette sub-family G member 2transporter
DB09065CobicistatSolute carrier organic anion transporter family member 1B1transporter
DB09065CobicistatSolute carrier organic anion transporter family member 1B3transporter
DB09118StiripentolCytochrome P450 2C19enzyme
DB09118StiripentolCytochrome P450 2D6enzyme
DB09118StiripentolCytochrome P450 3A4enzyme
DB09118StiripentolCytochrome P450 1A2enzyme
DB09118StiripentolCytochrome P450 2C9enzyme
DB09118StiripentolGABA-A receptor (anion channel)target
DB09118StiripentolL-lactate dehydrogenase A chaintarget
DB09118StiripentolL-lactate dehydrogenase B chaintarget
DB11672CurcuminCytochrome P450 2C9enzyme
DB11672CurcuminCytochrome P450 3A4enzyme
DB11672CurcuminCytochrome P450 2B6enzyme
DB11672CurcuminCytochrome P450 1A2enzyme
DB11672CurcuminCytochrome P450 2D6enzyme
DB11672CurcuminGlutathione S-transferase A1enzyme
DB11672CurcuminGlutathione S-transferase Mu 1enzyme
DB11672CurcuminGlutathione S-transferase Penzyme
DB11672CurcuminPeroxisome proliferator-activated receptor gammatarget
DB11672CurcuminVitamin D3 receptortarget
DB11672CurcuminMultidrug resistance-associated protein 5target
DB11672CurcuminCarbonyl reductase [NADPH] 1target
DB11672CurcuminGlutathione S-transferase Ptarget
DB11672CurcuminMultidrug resistance protein 1transporter
DB00503RitonavirSerum albumincarrier
DB00503RitonavirCytochrome P450 2D6enzyme
DB00503RitonavirCytochrome P450 2C9enzyme
DB00503RitonavirCytochrome P450 2C19enzyme
DB00503RitonavirCytochrome P450 2B6enzyme
DB00503RitonavirCytochrome P450 2C8enzyme
DB00503RitonavirCytochrome P450 1A2enzyme
DB00503RitonavirCytochrome P450 2E1enzyme
DB00503RitonavirCytochrome P450 3A4enzyme
DB00503RitonavirCytochrome P450 3A5enzyme
DB00503RitonavirCytochrome P450 3A7enzyme
DB00503RitonavirCytochrome P450 3A43enzyme
DB00503RitonavirUDP-glucuronosyltransferase 1-1enzyme
DB00503RitonavirHuman immunodeficiency virus type 1 proteasetarget
DB00503RitonavirNuclear receptor subfamily 1 group I member 2target
DB00503RitonavirMultidrug resistance protein 1transporter
DB00503RitonavirMultidrug resistance-associated protein 1transporter
DB00503RitonavirCanalicular multispecific organic anion transporter 1transporter
DB00503RitonavirSolute carrier organic anion transporter family member 1A2transporter
DB00503RitonavirATP-binding cassette sub-family G member 2transporter
DB00503RitonavirSolute carrier organic anion transporter family member 1B1transporter
DB00503RitonavirSolute carrier organic anion transporter family member 2B1transporter
DB00503RitonavirBile salt export pumptransporter
DB00872ConivaptanCytochrome P450 3A4enzyme
DB00872ConivaptanVasopressin V1a receptortarget
DB00872ConivaptanVasopressin V2 receptortarget
DB13179TroleandomycinCytochrome P450 2C9enzyme
DB13179TroleandomycinCytochrome P450 3A5enzyme
DB13179TroleandomycinCytochrome P450 3A43enzyme
DB13179TroleandomycinCytochrome P450 2C18enzyme
DB13179TroleandomycinCytochrome P450 2C8enzyme
DB13179TroleandomycinCytochrome P450 3A4enzyme
DB13179TroleandomycinCytochrome P450 3A7enzyme
DB13179Troleandomycin50S ribosomal protein L4target
DB13179Troleandomycin50S ribosomal protein L32target
DB13179TroleandomycinNuclear receptor subfamily 1 group I member 2target
DB13179TroleandomycinMultidrug resistance protein 1transporter
DB01388MibefradilCytochrome P450 3A4enzyme
DB01388MibefradilCytochrome P450 1A2enzyme
DB01388MibefradilCytochrome P450 2D6enzyme
DB01388MibefradilCytochrome P450 3A5enzyme
DB01388MibefradilCytochrome P450 3A7enzyme
DB01388MibefradilCytochrome P450 11B1, mitochondrialenzyme
DB01388MibefradilCytochrome P450 11B2, mitochondrialenzyme
DB01388MibefradilCytochrome P450 1A1enzyme
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-1target
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-2target
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-3target
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-4target
DB01388MibefradilMultidrug resistance protein 1transporter
DB00254DoxycyclineCytochrome P450 3A4enzyme
DB00254Doxycycline30S ribosomal protein S4target
DB00254Doxycycline30S ribosomal protein S9target
DB00254Doxycycline16S rRNAtarget
DB00254DoxycyclineProtein-arginine deiminase type-4target
DB00254DoxycyclineBeta-2-microglobulintarget
DB00254DoxycyclineSolute carrier family 22 member 6transporter
DB00254DoxycyclineSolute carrier family 22 member 8transporter
DB00254DoxycyclineSolute carrier family 22 member 11transporter
DB00625EfavirenzSerum albumincarrier
DB00625EfavirenzCytochrome P450 2B6enzyme
DB00625EfavirenzCytochrome P450 3A4enzyme
DB00625EfavirenzCytochrome P450 2C19enzyme
DB00625EfavirenzCytochrome P450 2C9enzyme
DB00625EfavirenzCytochrome P450 1A2enzyme
DB00625EfavirenzCytochrome P450 2D6enzyme
DB00625EfavirenzCytochrome P450 2C8enzyme
DB00625EfavirenzCytochrome P450 3A5enzyme
DB00625EfavirenzCytochrome P450 3A7enzyme
DB00625EfavirenzUDP-glucuronosyltransferase 1-1enzyme
DB00625EfavirenzReverse transcriptase/RNaseHtarget
DB00625EfavirenzBile salt export pumptransporter
DB01072AtazanavirSerum albumincarrier
DB01072AtazanavirCytochrome P450 3A4enzyme
DB01072AtazanavirCytochrome P450 2C9enzyme
DB01072AtazanavirUDP-glucuronosyltransferase 1-1enzyme
DB01072AtazanavirCytochrome P450 2C8enzyme
DB01072AtazanavirHuman immunodeficiency virus type 1 proteasetarget
DB01072AtazanavirMultidrug resistance protein 1transporter
DB01072AtazanavirMultidrug resistance-associated protein 1transporter
DB01072AtazanavirSolute carrier organic anion transporter family member 1B1transporter
DB01072AtazanavirSolute carrier organic anion transporter family member 1B3transporter
DB01072AtazanavirBile salt export pumptransporter
DB00932TipranavirCytochrome P450 3A4enzyme
DB00932TipranavirCytochrome P450 2D6enzyme
DB00932TipranavirCytochrome P450 2C19enzyme
DB00932TipranavirUDP-glucuronosyltransferase 1-1enzyme
DB00932TipranavirHuman immunodeficiency virus type 1 proteasetarget
DB00932TipranavirBile salt export pumptransporter
DB00932TipranavirSolute carrier organic anion transporter family member 2B1transporter
DB00932TipranavirSolute carrier organic anion transporter family member 1B1transporter
DB00932TipranavirSolute carrier organic anion transporter family member 1B3transporter
DB01183NaloxoneSerum albumincarrier
DB01183NaloxoneCytochrome P450 2C8enzyme
DB01183NaloxoneCytochrome P450 3A4enzyme
DB01183NaloxoneUDP-glucuronosyltransferase 1-1enzyme
DB01183NaloxoneMu-type opioid receptortarget
DB01183NaloxoneEstrogen receptor alphatarget
DB01183NaloxoneCyclic AMP-responsive element-binding protein 1target
DB01183NaloxoneDelta-type opioid receptortarget
DB01183NaloxoneKappa-type opioid receptortarget
DB01183NaloxoneToll-like receptor 4target
DB01183NaloxoneLiver carboxylesterase 1target
DB01183NaloxoneSolute carrier organic anion transporter family member 1A2transporter
DB01183NaloxoneMultidrug resistance protein 1transporter
DB00257ClotrimazoleCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB00257ClotrimazoleCytochrome P450 2D6enzyme
DB00257ClotrimazoleCytochrome P450 2C8enzyme
DB00257ClotrimazoleCytochrome P450 3A4enzyme
DB00257ClotrimazoleCytochrome P450 2B6enzyme
DB00257ClotrimazoleCytochrome P450 11B1, mitochondrialenzyme
DB00257ClotrimazoleCytochrome P450 19A1enzyme
DB00257ClotrimazoleCytochrome P450 2A6enzyme
DB00257ClotrimazoleCytochrome P450 2C9enzyme
DB00257ClotrimazoleCytochrome P450 2E1enzyme
DB00257ClotrimazoleCytochrome P450 3A7enzyme
DB00257ClotrimazoleIntermediate conductance calcium-activated potassium channel protein 4target
DB00257ClotrimazoleLanosterol 14-alpha demethylasetarget
DB00257ClotrimazoleNuclear receptor subfamily 1 group I member 2target
DB00257ClotrimazoleNuclear receptor subfamily 1 group I member 3target
DB00257ClotrimazoleCanalicular multispecific organic anion transporter 2transporter
DB00257ClotrimazoleMultidrug resistance protein 1transporter
DB00257ClotrimazoleCanalicular multispecific organic anion transporter 1transporter
DB00257ClotrimazoleBile salt export pumptransporter
DB04868NilotinibCytochrome P450 2D6enzyme
DB04868NilotinibCytochrome P450 2C8enzyme
DB04868NilotinibCytochrome P450 2C9enzyme
DB04868NilotinibCytochrome P450 3A4enzyme
DB04868NilotinibCytochrome P450 2B6enzyme
DB04868NilotinibTyrosine-protein kinase ABL1target
DB04868NilotinibMast/stem cell growth factor receptor Kittarget
DB04868NilotinibMultidrug resistance protein 1transporter
DB04868NilotinibATP-binding cassette sub-family G member 2transporter
DB04868NilotinibUDP-glucuronosyltransferase 1-1transporter
DB04868NilotinibSolute carrier organic anion transporter family member 1B1transporter
DB00705DelavirdineCytochrome P450 3A4enzyme
DB00705DelavirdineCytochrome P450 2C9enzyme
DB00705DelavirdineCytochrome P450 2D6enzyme
DB00705DelavirdineCytochrome P450 3A5enzyme
DB00705DelavirdineCytochrome P450 3A7enzyme
DB00705DelavirdineCytochrome P450 2C19enzyme
DB00705DelavirdineCytochrome P450 2C8enzyme
DB00705DelavirdineReverse transcriptase/RNaseHtarget
DB00836LoperamideCytochrome P450 3A4enzyme
DB00836LoperamideCytochrome P450 2C8enzyme
DB00836LoperamideCytochrome P450 2B6enzyme
DB00836LoperamideCytochrome P450 2D6enzyme
DB00836LoperamideVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00836LoperamideMu-type opioid receptortarget
DB00836LoperamideCalmodulintarget
DB00836LoperamidePro-opiomelanocortintarget
DB00836LoperamideDelta-type opioid receptortarget
DB00836LoperamideKappa-type opioid receptortarget
DB00836LoperamideNuclear receptor subfamily 1 group I member 3target
DB00836LoperamideMultidrug resistance protein 1transporter
DB11730RibociclibCytochrome P450 3A4enzyme
DB11730RibociclibCyclin-dependent kinase 4target
DB11730RibociclibCyclin-dependent kinase 6target
DB11779DanoprevirCytochrome P450 3A4enzyme
DB11779DanoprevirGenome polyproteintarget
DB09101ElvitegravirCytochrome P450 3A4enzyme
DB09101ElvitegravirUDP-glucuronosyltransferase 1A1enzyme
DB09101ElvitegravirIntegrasetarget
DB06595MidostaurinCYP3Aenzyme
DB06595MidostaurinCytochrome P450 1A2enzyme
DB06595MidostaurinCytochrome P450 2B6enzyme
DB06595MidostaurinCytochrome P450 2C8enzyme
DB06595MidostaurinCytochrome P450 2C9enzyme
DB06595MidostaurinCytochrome P450 2C19enzyme
DB06595MidostaurinCytochrome P450 2D6enzyme
DB06595MidostaurinCytochrome P450 2E1enzyme
DB06595MidostaurinCytochrome P450 3A4enzyme
DB06595MidostaurinCytochrome P450 3A5enzyme
DB06595MidostaurinCytochrome P450 3A7enzyme
DB06595MidostaurinCytochrome P450 3A43enzyme
DB06595MidostaurinProtein kinase C alpha typetarget
DB06595MidostaurinVascular endothelial growth factor receptor 2target
DB06595MidostaurinMast/stem cell growth factor receptor Kittarget
DB06595MidostaurinPlatelet-derived growth factor receptor alphatarget
DB06595MidostaurinPlatelet-derived growth factor receptor betatarget
DB06595MidostaurinReceptor-type tyrosine-protein kinase FLT3target
DB00342TerfenadineCytochrome P450 3A4enzyme
DB00342TerfenadineCytochrome P450 2D6enzyme
DB00342TerfenadineCytochrome P450 3A5enzyme
DB00342TerfenadineCytochrome P450 3A7enzyme
DB00342TerfenadineCytochrome P450 2C8enzyme
DB00342TerfenadineCytochrome P450 2J2enzyme
DB00342TerfenadineHistamine H1 receptortarget
DB00342TerfenadinePotassium voltage-gated channel subfamily H member 2target
DB00342TerfenadineMuscarinic acetylcholine receptor M3target
DB00342TerfenadineMuscarinic acetylcholine receptor M1target
DB00342TerfenadineMuscarinic acetylcholine receptor M5target
DB00342TerfenadineMuscarinic acetylcholine receptor M4target
DB00342TerfenadineMuscarinic acetylcholine receptor M2target
DB00342TerfenadineMultidrug resistance protein 1transporter
DB00342TerfenadineBile salt export pumptransporter
DB00696ErgotamineCytochrome P450 3A4enzyme
DB00696ErgotamineAlpha-1A adrenergic receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Dtarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Btarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Atarget
DB00696ErgotamineAlpha-2A adrenergic receptortarget
DB00696ErgotamineD(2) dopamine receptortarget
DB00696ErgotamineAlpha-2B adrenergic receptortarget
DB00696ErgotamineSodium-dependent noradrenaline transportertarget
DB00696ErgotamineAlpha-1B adrenergic receptortarget
DB00696ErgotamineAlpha-1D adrenergic receptortarget
DB00696ErgotamineD(1) dopamine receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Atarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Ftarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Ctarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Btarget
DB00696ErgotamineMultidrug resistance protein 1transporter
DB01127EconazoleCytochrome P450 19A1enzyme
DB01127EconazoleCytochrome P450 2E1enzyme
DB01127EconazoleCytochrome P450 3A4enzyme
DB01127EconazoleLanosterol 14-alpha demethylasetarget
DB01127EconazoleNuclear receptor subfamily 1 group I member 2target