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Identification
NameChlorzoxazone
Accession NumberDB00356  (APRD00308)
TypeSmall Molecule
GroupsApproved
DescriptionA centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
Structure
Thumb
Synonyms
2-hydroxy-5-chlorobenzoxazole
5-chloro-2-Benzoxazolinone
5-chloro-2-Benzoxazolol
5-chloro-2-Benzoxazolone
5-chloro-2-Hydroxybenzoxazole
5-chloro-2(3H)-benzoxazolone
5-chloro-3H-benzooxazol-2-one
5-Chlorobenzoxazolidone
5-chlorobenzoxazolin-2-one
Chlorzoxane
Chlorzoxazon
Chlorzoxazona
Chlorzoxazone
Chlorzoxazonum
Clorzoxazona
Clorzoxazone
External Identifiers
  • MI 315
  • USAF MA-10
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Parafon Forte DscTablet500 mg/1OralJanssen Pharmaceuticals, Inc.1987-06-15Not applicableUs
Parafon Forte DscTablet500 mg/1OralREMEDYREPACK INC.2012-11-282017-11-07Us
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ChlorzoxazoneTablet500 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-04-12Not applicableUs
ChlorzoxazoneTablet500 mg/1OralA S Medication Solutions2011-08-22Not applicableUs
ChlorzoxazoneTablet500 mg/1OralActavis Pharma, Inc.2011-08-22Not applicableUs
ChlorzoxazoneTablet500 mg/1OralPd Rx Pharmaceuticals, Inc.2008-12-23Not applicableUs
ChlorzoxazoneTablet500 mg/1OralRebel Distributors Corp2011-08-22Not applicableUs
ChlorzoxazoneTablet500 mg/1OralClinical Solutions Wholesale2011-08-22Not applicableUs
ChlorzoxazoneTablet500 mg/1OralA S Medication Solutions2011-08-22Not applicableUs
ChlorzoxazoneTablet500 mg/1OralUnit Dose Services2011-08-22Not applicableUs
ChlorzoxazoneTablet500 mg/1OralSTAT Rx USA LLC2008-12-23Not applicableUs
ChlorzoxazoneTablet500 mg/1OralProficient Rx LP2011-08-22Not applicableUs
ChlorzoxazoneTablet750 mg/1OralMikart Inc.2010-06-01Not applicableUs
ChlorzoxazoneTablet500 mg/1OralREMEDYREPACK INC.2015-11-13Not applicableUs
ChlorzoxazoneTablet500 mg/1OralPhysicians Total Care, Inc.1995-04-24Not applicableUs
ChlorzoxazoneTablet500 mg/1OralNu Care Pharmaceuticals, Inc.2011-08-22Not applicableUs
ChlorzoxazoneTablet500 mg/1OralRebel Distributors Corp1988-05-04Not applicableUs
ChlorzoxazoneTablet500 mg/1Oralbryant ranch prepack2008-12-23Not applicableUs
ChlorzoxazoneTablet375 mg/1OralMikart Inc.2010-06-01Not applicableUs
ChlorzoxazoneTablet250 mg/1OralMikart, Inc.2016-06-24Not applicableUs
ChlorzoxazoneTablet500 mg/1OralDispensing Solutions, Inc.2011-01-16Not applicableUs
ChlorzoxazoneTablet500 mg/1OralDIRECT RX2014-01-01Not applicableUs
ChlorzoxazoneTablet500 mg/1OralAidarex Pharmaceuticals LLC2011-08-22Not applicableUs
ChlorzoxazoneTablet500 mg/1OralA S Medication Solutions2011-08-22Not applicableUs
ChlorzoxazoneTablet500 mg/1Occlusive dressing techniqueDispensing Solutions, Inc.2008-12-23Not applicableUs
LorzoneTablet375 mg/1OralVertical Pharmaceuticals, LLC2011-10-01Not applicableUs
LorzoneTablet750 mg/1OralVertical Pharmaceuticals, LLC2011-10-01Not applicableUs
Parafon DscTablet500 mg/1OralKeltman Pharmaceuticals Inc.2004-06-20Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
MyoflexinZentiva
ParaflexBioPhausia
RelaxazoneNot Available
RemularNot Available
Remular-SNot Available
SolaxinEisai
Strifon Forte DSCNot Available
Brand mixtures
NameLabellerIngredients
Acetazone ForteTeva Canada Limited
Acetazone Forte C8Teva Canada Limited
Back-aid Forte - TabRougier Pharma Division Of Ratiopharm Inc
Extra Strength Tylenol Aches and StrainsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Gin Pain Pills - TabStella Pharmaceutical Canada Inc.
Parafon ForteMcneil Pharmaceutical, Division Of Ortho Mcneil Inc.
Parafon Forte C8 W Codeine TabMcneil Pharmaceutical, Division Of Ortho Mcneil Inc.
Parafon Forte TabletsJohnson & Johnson Merck Consumer Pharmaceuticals Of Canada
SaltsNot Available
Categories
UNIIH0DE420U8G
CAS number95-25-0
WeightAverage: 169.565
Monoisotopic: 168.993056084
Chemical FormulaC7H4ClNO2
InChI KeyTZFWDZFKRBELIQ-UHFFFAOYSA-N
InChI
InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
IUPAC Name
5-chloro-2,3-dihydro-1,3-benzoxazol-2-one
SMILES
ClC1=CC2=C(OC(=O)N2)C=C1
Pharmacology
IndicationFor the relief of discomfort associated with acute painful musculoskeletal conditions.
Structured Indications
PharmacodynamicsChlorzoxazone, a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Chlorzoxazone is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis. Chlorzoxazone is also a centrally-acting agent for painful musculoskeletal conditions. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex a.c. involved in producing and maintaining skeletal muscle spasm of varied etiology. The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles.
Mechanism of actionChlorzoxazone inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Chlorzoxazone also may reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium and potassium influx which would lead to neuronal inhibition and muscle relaxation. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex arcs involved in producing and maintaining skeletal muscle spasm
TargetKindPharmacological actionActionsOrganismUniProt ID
Calcium-activated potassium channel subunit alpha-1ProteinyesNot AvailableHumanQ12791 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein binding13-18%
Metabolism

Chlorzoxazone is rapidly metabolized in the liver and is excreted in the urine, primarily in a conjugated form as the glucuronide.

SubstrateEnzymesProduct
Chlorzoxazone
6-hydroxychlorzoxazoneDetails
Route of eliminationChlorzoxazone is rapidly metabolized and is excreted in the urine, primarily in a conjugated form as the glucuronide.
Half lifeNot Available
ClearanceNot Available
ToxicityOral, mouse: LD50 = 440 mg/kg; Oral, rat: LD50 = 763 mg/kg; Symptoms of overdose include diarrhea, dizziness, drowsiness, headache, light-headedness, nausea, and vomiting.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Chlorzoxazone.Experimental
AbirateroneThe serum concentration of Chlorzoxazone can be increased when it is combined with Abiraterone.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Chlorzoxazone.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Chlorzoxazone.Approved
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Chlorzoxazone.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Chlorzoxazone.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Chlorzoxazone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chlorzoxazone.Approved, Illicit
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Chlorzoxazone.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlorzoxazone.Approved, Illicit, Investigational
AmiodaroneThe metabolism of Chlorzoxazone can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Chlorzoxazone.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Chlorzoxazone.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Chlorzoxazone.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Chlorzoxazone.Experimental
AprepitantThe serum concentration of Chlorzoxazone can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Chlorzoxazone.Approved, Investigational
ArtemetherThe metabolism of Chlorzoxazone can be decreased when combined with Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Chlorzoxazone.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Chlorzoxazone.Approved
AtazanavirThe metabolism of Chlorzoxazone can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Chlorzoxazone can be decreased when combined with Atomoxetine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Chlorzoxazone.Vet Approved
AzelastineChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Azelastine.Approved
AzithromycinThe metabolism of Chlorzoxazone can be decreased when combined with Azithromycin.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Chlorzoxazone.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Chlorzoxazone.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chlorzoxazone.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Chlorzoxazone.Approved
BetaxololThe metabolism of Chlorzoxazone can be decreased when combined with Betaxolol.Approved
BexaroteneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Bexarotene.Approved, Investigational
BoceprevirThe metabolism of Chlorzoxazone can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Chlorzoxazone can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Chlorzoxazone can be decreased when it is combined with Bosentan.Approved, Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Chlorzoxazone.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Chlorzoxazone.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlorzoxazone.Approved, Investigational
BuprenorphineChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Chlorzoxazone can be decreased when combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Chlorzoxazone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Chlorzoxazone.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Chlorzoxazone.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Chlorzoxazone.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Chlorzoxazone.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Chlorzoxazone.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Chlorzoxazone.Approved, Illicit, Vet Approved
CaffeineThe metabolism of Chlorzoxazone can be decreased when combined with Caffeine.Approved
CarbamazepineThe metabolism of Chlorzoxazone can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorzoxazone.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Carisoprodol.Approved
CelecoxibThe metabolism of Chlorzoxazone can be decreased when combined with Celecoxib.Approved, Investigational
CeritinibThe serum concentration of Chlorzoxazone can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Chlorzoxazone.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Chlorzoxazone.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlorzoxazone.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Chlorzoxazone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Chlorzoxazone.Approved
ChloroquineThe metabolism of Chlorzoxazone can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Chlorphenamine.Approved
ChlorpromazineThe metabolism of Chlorzoxazone can be decreased when combined with Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Chlorzoxazone.Approved, Withdrawn
CholecalciferolThe metabolism of Chlorzoxazone can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CimetidineThe metabolism of Chlorzoxazone can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Chlorzoxazone can be decreased when combined with Cinacalcet.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Chlorzoxazone.Approved, Vet Approved
CitalopramThe metabolism of Chlorzoxazone can be decreased when combined with Citalopram.Approved
ClarithromycinThe metabolism of Chlorzoxazone can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Chlorzoxazone can be decreased when combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Clidinium.Approved
ClobazamThe metabolism of Chlorzoxazone can be decreased when combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Chlorzoxazone.Investigational
ClomipramineThe metabolism of Chlorzoxazone can be decreased when combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Chlorzoxazone.Approved, Illicit
ClotrimazoleThe metabolism of Chlorzoxazone can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Chlorzoxazone can be decreased when combined with Clozapine.Approved
CobicistatThe serum concentration of Chlorzoxazone can be increased when it is combined with Cobicistat.Approved
CocaineThe metabolism of Chlorzoxazone can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Chlorzoxazone.Approved, Illicit
ConivaptanThe serum concentration of Chlorzoxazone can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Chlorzoxazone can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Chlorzoxazone.Approved
CyclosporineThe metabolism of Chlorzoxazone can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Cyproheptadine.Approved
Cyproterone acetateThe serum concentration of Chlorzoxazone can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
DabrafenibThe serum concentration of Chlorzoxazone can be decreased when it is combined with Dabrafenib.Approved
DantroleneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Chlorzoxazone.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Dapoxetine.Investigational
DarifenacinThe metabolism of Chlorzoxazone can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Chlorzoxazone can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Chlorzoxazone can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Chlorzoxazone can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Chlorzoxazone can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Chlorzoxazone.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Chlorzoxazone.Approved
DesipramineThe metabolism of Chlorzoxazone can be decreased when combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Chlorzoxazone.Vet Approved
DexamethasoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Chlorzoxazone.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Chlorzoxazone.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chlorzoxazone.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorzoxazone.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Chlorzoxazone.Approved, Illicit, Vet Approved
DifenoxinThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Chlorzoxazone.Approved, Illicit
DihydroergotamineThe metabolism of Chlorzoxazone can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Chlorzoxazone.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Chlorzoxazone.Experimental, Illicit
DiltiazemThe metabolism of Chlorzoxazone can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Dimenhydrinate.Approved
DiphenhydramineThe metabolism of Chlorzoxazone can be decreased when combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Chlorzoxazone.Approved, Illicit
DisulfiramThe metabolism of Chlorzoxazone can be decreased when combined with Disulfiram.Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Chlorzoxazone.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Doxepin.Approved
DoxycyclineThe metabolism of Chlorzoxazone can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Chlorzoxazone.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved, Illicit
DronedaroneThe metabolism of Chlorzoxazone can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Chlorzoxazone.Experimental, Illicit
DuloxetineThe metabolism of Chlorzoxazone can be decreased when combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Chlorzoxazone.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Chlorzoxazone.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Chlorzoxazone.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Ecopipam.Investigational
EfavirenzThe serum concentration of Chlorzoxazone can be decreased when it is combined with Efavirenz.Approved, Investigational
EliglustatThe metabolism of Chlorzoxazone can be decreased when combined with Eliglustat.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Chlorzoxazone.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Chlorzoxazone can be decreased when it is combined with Enzalutamide.Approved
ErythromycinThe metabolism of Chlorzoxazone can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Chlorzoxazone can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Chlorzoxazone.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Chlorzoxazone.Approved
EthanolChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Chlorzoxazone.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Chlorzoxazone.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Chlorzoxazone.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Chlorzoxazone.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Chlorzoxazone.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Chlorzoxazone.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Chlorzoxazone.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Chlorzoxazone.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Chlorzoxazone.Illicit, Vet Approved
EtravirineThe serum concentration of Chlorzoxazone can be decreased when it is combined with Etravirine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Chlorzoxazone.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Chlorzoxazone.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Flibanserin.Approved
FluconazoleThe metabolism of Chlorzoxazone can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Chlorzoxazone.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Chlorzoxazone.Approved, Illicit
FluoxetineThe metabolism of Chlorzoxazone can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Chlorzoxazone.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Chlorzoxazone.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Chlorzoxazone.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Chlorzoxazone.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Fluticasone Propionate.Approved
FluvoxamineThe metabolism of Chlorzoxazone can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Chlorzoxazone can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Chlorzoxazone can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Chlorzoxazone can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Chlorzoxazone.Approved, Illicit
Fusidic AcidThe serum concentration of Chlorzoxazone can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Chlorzoxazone.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Chlorzoxazone.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chlorzoxazone.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Chlorzoxazone.Approved, Illicit, Withdrawn
HaloperidolThe metabolism of Chlorzoxazone can be decreased when combined with Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Chlorzoxazone.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorzoxazone.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Chlorzoxazone.Approved
HydrocodoneChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Chlorzoxazone.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved
IdelalisibThe serum concentration of Chlorzoxazone can be increased when it is combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Iloperidone.Approved
ImatinibThe metabolism of Chlorzoxazone can be decreased when combined with Imatinib.Approved
ImipramineThe metabolism of Chlorzoxazone can be decreased when combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Chlorzoxazone can be decreased when combined with Indinavir.Approved
IsavuconazoniumThe metabolism of Chlorzoxazone can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Chlorzoxazone.Approved, Vet Approved
IsoniazidThe metabolism of Chlorzoxazone can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Chlorzoxazone can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Chlorzoxazone can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Chlorzoxazone can be increased when it is combined with Ivacaftor.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Chlorzoxazone.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Chlorzoxazone.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Chlorzoxazone.Approved
KetoconazoleThe metabolism of Chlorzoxazone can be decreased when combined with Ketoconazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Chlorzoxazone.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Chlorzoxazone.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Chlorzoxazone.Approved
LidocaineThe metabolism of Chlorzoxazone can be decreased when combined with Lidocaine.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Chlorzoxazone.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Chlorzoxazone.Illicit
LopinavirThe metabolism of Chlorzoxazone can be decreased when combined with Lopinavir.Approved
LoratadineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorzoxazone.Approved
LorcaserinThe metabolism of Chlorzoxazone can be decreased when combined with Lorcaserin.Approved
LovastatinThe metabolism of Chlorzoxazone can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Chlorzoxazone.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Chlorzoxazone.Investigational
LuliconazoleThe serum concentration of Chlorzoxazone can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Chlorzoxazone can be increased when combined with Lumacaftor.Approved
LumefantrineThe metabolism of Chlorzoxazone can be decreased when combined with Lumefantrine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Chlorzoxazone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Chlorzoxazone.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Chlorzoxazone.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Chlorzoxazone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Chlorzoxazone.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Chlorzoxazone.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Chlorzoxazone.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Metaxalone.Approved
MethadoneThe metabolism of Chlorzoxazone can be decreased when combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorzoxazone.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Chlorzoxazone.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Chlorzoxazone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Chlorzoxazone.Approved
MethotrimeprazineChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Chlorzoxazone.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Chlorzoxazone.Approved
MetoprololThe metabolism of Chlorzoxazone can be decreased when combined with Metoprolol.Approved, Investigational
MetyrosineChlorzoxazone may increase the sedative activities of Metyrosine.Approved
MexiletineThe metabolism of Chlorzoxazone can be decreased when combined with Mexiletine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Chlorzoxazone.Approved, Illicit
MifepristoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved, Investigational
MirabegronThe metabolism of Chlorzoxazone can be decreased when combined with Mirabegron.Approved
MirtazapineChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Chlorzoxazone can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Chlorzoxazone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Chlorzoxazone.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved, Investigational
NafcillinThe serum concentration of Chlorzoxazone can be decreased when it is combined with Nafcillin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Chlorzoxazone.Approved
NefazodoneThe metabolism of Chlorzoxazone can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Chlorzoxazone can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Chlorzoxazone can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Chlorzoxazone can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Chlorzoxazone can be decreased when combined with Nicardipine.Approved
NicotineThe metabolism of Chlorzoxazone can be decreased when combined with Nicotine.Approved
NilotinibThe metabolism of Chlorzoxazone can be decreased when combined with Nilotinib.Approved, Investigational
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Chlorzoxazone.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chlorzoxazone.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Chlorzoxazone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Chlorzoxazone.Approved, Investigational
OlaparibThe metabolism of Chlorzoxazone can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Chlorzoxazone.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Chlorzoxazone.Approved, Illicit
OrphenadrineChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Chlorzoxazone.Investigational
OsimertinibThe serum concentration of Chlorzoxazone can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Chlorzoxazone.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Chlorzoxazone.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Chlorzoxazone.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorzoxazone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Chlorzoxazone.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of Chlorzoxazone can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Chlorzoxazone.Approved
PanobinostatThe serum concentration of Chlorzoxazone can be increased when it is combined with Panobinostat.Approved, Investigational
ParaldehydeChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe metabolism of Chlorzoxazone can be decreased when combined with Paroxetine.Approved, Investigational
Peginterferon alfa-2bThe serum concentration of Chlorzoxazone can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Chlorzoxazone.Approved, Vet Approved
PentobarbitalThe metabolism of Chlorzoxazone can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved
PerazineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Chlorzoxazone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Chlorzoxazone.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Chlorzoxazone.Approved
PhenobarbitalThe metabolism of Chlorzoxazone can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Chlorzoxazone.Approved
PhenytoinThe metabolism of Chlorzoxazone can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Chlorzoxazone.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Chlorzoxazone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Pomalidomide.Approved
PosaconazoleThe metabolism of Chlorzoxazone can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleChlorzoxazone may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Chlorzoxazone.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Chlorzoxazone.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorzoxazone.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chlorzoxazone.Approved
PrimidoneThe metabolism of Chlorzoxazone can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Chlorzoxazone.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Chlorzoxazone.Approved, Vet Approved
PromazineThe metabolism of Chlorzoxazone can be decreased when combined with Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chlorzoxazone.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Chlorzoxazone.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Chlorzoxazone.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Chlorzoxazone.Approved
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Chlorzoxazone.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Chlorzoxazone.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Chlorzoxazone.Approved
QuinidineThe metabolism of Chlorzoxazone can be decreased when combined with Quinidine.Approved
QuinineThe metabolism of Chlorzoxazone can be decreased when combined with Quinine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Ramelteon.Approved, Investigational
RanolazineThe metabolism of Chlorzoxazone can be decreased when combined with Ranolazine.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Chlorzoxazone.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Chlorzoxazone.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Chlorzoxazone.Approved
RifabutinThe metabolism of Chlorzoxazone can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Chlorzoxazone can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Chlorzoxazone can be increased when combined with Rifapentine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Chlorzoxazone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Ritanserin.Investigational
RitonavirThe metabolism of Chlorzoxazone can be decreased when combined with Ritonavir.Approved, Investigational
RolapitantThe metabolism of Chlorzoxazone can be decreased when combined with Rolapitant.Approved
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Chlorzoxazone.Vet Approved
RopiniroleChlorzoxazone may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Chlorzoxazone.Approved
RotigotineChlorzoxazone may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Chlorzoxazone.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Chlorzoxazone.Experimental
Sage 547The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Sage 547.Investigational
SaquinavirThe metabolism of Chlorzoxazone can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Chlorzoxazone.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Chlorzoxazone.Approved, Withdrawn
SertralineThe metabolism of Chlorzoxazone can be decreased when combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Chlorzoxazone.Approved, Vet Approved
SildenafilThe metabolism of Chlorzoxazone can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Chlorzoxazone can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Chlorzoxazone can be increased when it is combined with Simeprevir.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved
St. John's WortThe serum concentration of Chlorzoxazone can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Chlorzoxazone can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Chlorzoxazone.Approved, Investigational
SulfisoxazoleThe metabolism of Chlorzoxazone can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Chlorzoxazone.Approved
SuvorexantChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Tasimelteon.Approved
TelaprevirThe metabolism of Chlorzoxazone can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Chlorzoxazone can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Chlorzoxazone.Approved
TenofovirThe metabolism of Chlorzoxazone can be decreased when combined with Tenofovir.Approved, Investigational
TerbinafineThe metabolism of Chlorzoxazone can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TeriflunomideThe serum concentration of Chlorzoxazone can be decreased when it is combined with Teriflunomide.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Chlorzoxazone.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Chlorzoxazone.Investigational
ThalidomideChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Chlorzoxazone can be decreased when combined with Theophylline.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Chlorzoxazone.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Chlorzoxazone.Approved, Vet Approved
ThioridazineThe metabolism of Chlorzoxazone can be decreased when combined with Thioridazine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Chlorzoxazone.Approved
TiagabineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Tiapride.Investigational
TiclopidineThe metabolism of Chlorzoxazone can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Chlorzoxazone.Vet Approved
TipranavirThe metabolism of Chlorzoxazone can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Tizanidine.Approved
TocilizumabThe serum concentration of Chlorzoxazone can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Chlorzoxazone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Chlorzoxazone.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Chlorzoxazone.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Chlorzoxazone.Experimental
TranylcypromineThe metabolism of Chlorzoxazone can be decreased when combined with Tranylcypromine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Chlorzoxazone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Chlorzoxazone.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Chlorzoxazone.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Chlorzoxazone.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Uc1010.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Chlorzoxazone.Approved, Investigational
VemurafenibThe serum concentration of Chlorzoxazone can be increased when it is combined with Vemurafenib.Approved
VenlafaxineThe metabolism of Chlorzoxazone can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Chlorzoxazone can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Vigabatrin.Approved
VoriconazoleThe metabolism of Chlorzoxazone can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Chlorzoxazone.Approved
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Chlorzoxazone.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Chlorzoxazone.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Chlorzoxazone can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Chlorzoxazone.Vet Approved
ZolpidemChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Chlorzoxazone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Chlorzoxazone.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Chlorzoxazone.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.
References
Synthesis Reference

Marsh, D.F.; US. Patent 2,895,877; July 21, 1959; assigned to McNeil Laboratories, Inc.

General References
  1. Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF: Chlorzoxazone inhibits contraction of rat thoracic aorta. Eur J Pharmacol. 2006 Sep 18;545(2-3):161-6. Epub 2006 Jun 29. [PubMed:16859676 ]
  2. Park JY, Kim KA, Park PW, Ha JM: Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe. J Clin Pharmacol. 2006 Jan;46(1):109-14. [PubMed:16397290 ]
  3. Wan J, Ernstgard L, Song BJ, Shoaf SE: Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats. J Pharm Pharmacol. 2006 Jan;58(1):51-61. [PubMed:16393464 ]
External Links
ATC CodesM03BB73M03BB03M03BB53
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (61.8 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.991
Caco-2 permeable+0.5
P-glycoprotein substrateNon-substrate0.8733
P-glycoprotein inhibitor INon-inhibitor0.9784
P-glycoprotein inhibitor IINon-inhibitor0.9263
Renal organic cation transporterNon-inhibitor0.9001
CYP450 2C9 substrateNon-substrate0.8243
CYP450 2D6 substrateSubstrate0.6471
CYP450 3A4 substrateNon-substrate0.5372
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorNon-inhibitor0.9539
CYP450 2D6 inhibitorNon-inhibitor0.9338
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9522
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.7957
CarcinogenicityNon-carcinogens0.9467
BiodegradationNot ready biodegradable0.9655
Rat acute toxicity2.2388 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8675
hERG inhibition (predictor II)Non-inhibitor0.9659
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Actavis totowa llc
  • Barr laboratories inc
  • Mikart inc
  • Mutual pharmaceutical co inc
  • Ohm laboratories inc
  • Par pharmaceutical inc
  • Pioneer pharmaceuticals inc
  • Sandoz inc
  • Watson laboratories inc
  • Ortho mcneil pharmaceutical inc
  • Ortho mcneil janssen pharmaceuticals inc
  • Ferndale laboratories inc
Packagers
Dosage forms
FormRouteStrength
TabletOral
TabletOcclusive dressing technique500 mg/1
TabletOral250 mg/1
TabletOral375 mg/1
TabletOral500 mg/1
TabletOral750 mg/1
Prices
Unit descriptionCostUnit
Parafon forte dsc 500 mg caplet2.65USD caplet
Chlorzoxazone 500 mg tablet0.87USD tablet
Chlorzoxazone 250 mg tablet0.18USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point191-191.5Marsh, D.F.; US. Patent 2,895,877; July 21, 1959; assigned to McNeil Laboratories, Inc.
water solubility1000 mg/LNot Available
logP1.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.96 mg/mLALOGPS
logP2.09ALOGPS
logP1.94ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)9.39ChemAxon
pKa (Strongest Basic)-2.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area38.33 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity41.07 m3·mol-1ChemAxon
Polarizability14.94 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzoxazolones. These are organic compounds containing a benzene fused to an oxazole ring (a five-member aliphatic ring with three carbon atoms, one oxygen atom, and one nitrogen atom) bearing a ketone group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzoxazoles
Sub ClassBenzoxazolones
Direct ParentBenzoxazolones
Alternative Parents
Substituents
  • Benzoxazolone
  • Chlorobenzene
  • Benzenoid
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Oxazole
  • Azole
  • Oxacycle
  • Azacycle
  • Monocarboxylic acid or derivatives
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
General Function:
Voltage-gated potassium channel activity
Specific Function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key ...
Gene Name:
KCNMA1
Uniprot ID:
Q12791
Molecular Weight:
137558.115 Da
References
  1. Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF: Chlorzoxazone inhibits contraction of rat thoracic aorta. Eur J Pharmacol. 2006 Sep 18;545(2-3):161-6. Epub 2006 Jun 29. [PubMed:16859676 ]
  2. Alvina K, Khodakhah K: KCa channels as therapeutic targets in episodic ataxia type-2. J Neurosci. 2010 May 26;30(21):7249-57. doi: 10.1523/JNEUROSCI.6341-09.2010. [PubMed:20505091 ]
  3. Syme CA, Gerlach AC, Singh AK, Devor DC: Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels. Am J Physiol Cell Physiol. 2000 Mar;278(3):C570-81. [PubMed:10712246 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Pelkonen O, Maenpaa J, Taavitsainen P, Rautio A, Raunio H: Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica. 1998 Dec;28(12):1203-53. [PubMed:9890159 ]
  2. Kurata N, Nishimura Y, Iwase M, Fischer NE, Tang BK, Inaba T, Yasuhara H: Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica. 1998 Nov;28(11):1041-7. [PubMed:9879636 ]
  3. Ernstgard L, Warholm M, Johanson G: Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity. Br J Clin Pharmacol. 2004 Aug;58(2):190-200. [PubMed:15255802 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Wiercinska P, Squires EJ: Chlorzoxazone metabolism by porcine cytochrome P450 enzymes and the effect of cytochrome b5. Drug Metab Dispos. 2010 May;38(5):857-62. doi: 10.1124/dmd.109.030528. Epub 2010 Feb 17. [PubMed:20164110 ]
  2. Warrington JS, Court MH, Greenblatt DJ, von Moltke LL: Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats. J Pharm Pharmacol. 2004 Jun;56(6):819-25. [PubMed:15231049 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Yang TJ, Sai Y, Krausz KW, Gonzalez FJ, Gelboin HV: Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver. Pharmacogenetics. 1998 Oct;8(5):375-82. [PubMed:9825829 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Shimada T, Tsumura F, Yamazaki H: Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Drug Metab Dispos. 1999 Nov;27(11):1274-80. [PubMed:10534312 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Gorski JC, Jones DR, Wrighton SA, Hall SD: Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone. Xenobiotica. 1997 Mar;27(3):243-56. [PubMed:9141232 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Shimada T, Tsumura F, Yamazaki H: Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Drug Metab Dispos. 1999 Nov;27(11):1274-80. [PubMed:10534312 ]
  3. Gorski JC, Jones DR, Wrighton SA, Hall SD: Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone. Xenobiotica. 1997 Mar;27(3):243-56. [PubMed:9141232 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23