Nausea and vomiting

Also known as: Nausea and/or vomiting / Nausea with vomiting / [D]Retching / Nausea and vomiting symptoms / Vomiting / Vomiting NOS / Vomited / Emesis

DrugDrug NameDrug Description
DB00673AprepitantA substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
DB00477ChlorpromazineA phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.
DB00985DimenhydrinateA medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.
DB00470DronabinolA synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy.
DB00450DroperidolA butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.
DB00889GranisetronA 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.
DB00557HydroxyzineAn antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.
DB01403MethotrimeprazineA phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.
DB00370MirtazapineA tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
DB00662TrimethobenzamideAn antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis.
DrugDrug NameTargetType
DB00673AprepitantNeurokinin 1 receptortarget
DB00673AprepitantCytochrome P450 3A4enzyme
DB00673AprepitantCytochrome P450 2C9enzyme
DB00673AprepitantCytochrome P450 2C19enzyme
DB00477ChlorpromazineDopamine D2 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Atarget
DB00477ChlorpromazineCytochrome P450 2D6enzyme
DB00477ChlorpromazineCholinesteraseenzyme
DB00477ChlorpromazineCytochrome P450 1A2enzyme
DB00477ChlorpromazineSerum albumincarrier
DB00477ChlorpromazineP-glycoprotein 1transporter
DB00477ChlorpromazineDopamine D1 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 1Atarget
DB00477ChlorpromazineAlpha-1A adrenergic receptortarget
DB00477ChlorpromazineAlpha-1B adrenergic receptortarget
DB00477ChlorpromazineCytochrome P450 2E1enzyme
DB00477ChlorpromazineCytochrome P450 3A4enzyme
DB00477ChlorpromazineHistamine H1 receptortarget
DB00477ChlorpromazinePotassium voltage-gated channel subfamily H member 2target
DB00477ChlorpromazineD(1) dopamine receptortarget
DB00477ChlorpromazineDopamine D3 receptortarget
DB00477ChlorpromazineDopamine D4 receptortarget
DB00477ChlorpromazineDopamine D5 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Ctarget
DB00477Chlorpromazine5-hydroxytryptamine 2 receptortarget
DB00477ChlorpromazineAlpha-1 adrenergic receptorstarget
DB00477ChlorpromazineAlpha-2 adrenergic receptorstarget
DB00477ChlorpromazineMuscarinic acetylcholine receptor M1target
DB00477ChlorpromazineMuscarinic acetylcholine receptor M3target
DB00477ChlorpromazineSphingomyelin phosphodiesterasetarget
DB00477ChlorpromazineCalmodulintarget
DB00477Chlorpromazinealpha1-acid glycoproteintarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 6target
DB00477Chlorpromazine5-hydroxytryptamine receptor 7target
DB00477ChlorpromazineHistamine H4 receptortarget
DB00477ChlorpromazineBile salt export pumptransporter
DB00985DimenhydrinateHistamine H1 receptortarget
DB00470DronabinolCannabinoid receptor 1target
DB00470DronabinolCytochrome P450 3A4enzyme
DB00470DronabinolCytochrome P450 2C9enzyme
DB00470DronabinolCannabinoid receptor 2target
DB00470DronabinolP-glycoprotein 1transporter
DB00470DronabinolATP-binding cassette sub-family G member 2transporter
DB00470DronabinolProstaglandin G/H synthase 1enzyme
DB00450DroperidolDopamine D2 receptortarget
DB00450DroperidolAlpha-1A adrenergic receptortarget
DB00889Granisetron5-hydroxytryptamine receptor 3Atarget
DB00889GranisetronCytochrome P450 3A4enzyme
DB00889GranisetronCytochrome P450 1A1enzyme
DB00557HydroxyzineHistamine H1 receptortarget
DB00557HydroxyzineCytochrome P450 2D6enzyme
DB00557HydroxyzineCytochrome P450 3A4enzyme
DB00557HydroxyzineCytochrome P450 3A5enzyme
DB01403MethotrimeprazineDopamine D3 receptortarget
DB01403MethotrimeprazineHistamine H1 receptortarget
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M1target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M2target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M3target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M4target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M5target
DB01403MethotrimeprazineAlpha-1A adrenergic receptortarget
DB01403MethotrimeprazineAlpha-1B adrenergic receptortarget
DB01403MethotrimeprazineAlpha-1D adrenergic receptortarget
DB01403MethotrimeprazineCytochrome P450 2D6enzyme
DB01403MethotrimeprazineDopamine D2 receptortarget
DB01403MethotrimeprazineDopamine D1 receptortarget
DB01403MethotrimeprazineDopamine D5 receptortarget
DB01403MethotrimeprazineDopamine D4 receptortarget
DB01403MethotrimeprazineAlpha-2A adrenergic receptortarget
DB01403MethotrimeprazineAlpha-2B adrenergic receptortarget
DB01403MethotrimeprazineAlpha-2C adrenergic receptortarget
DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Atarget
DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Ctarget
DB01403MethotrimeprazineCytochrome P450 2E1enzyme
DB00370Mirtazapine5-hydroxytryptamine receptor 2Atarget
DB00370Mirtazapine5HT3 serotonin receptortarget
DB00370MirtazapineAlpha-2A adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Ctarget
DB00370MirtazapineKappa-type opioid receptortarget
DB00370MirtazapineHistamine H1 receptortarget
DB00370MirtazapineCytochrome P450 1A2enzyme
DB00370MirtazapineCytochrome P450 3A4enzyme
DB00370MirtazapineCytochrome P450 2D6enzyme
DB00370MirtazapineAlpha-1 adrenergic receptorstarget
DB00370MirtazapineSodium-dependent serotonin transportertransporter
DrugDrug NamePhaseStatusCount
DB00673Aprepitant1Completed1
DB00531Cyclophosphamide1Completed1
DB00333Methadone1Terminated1
DB00673Aprepitant2Completed2
DB04690Camptothecin2Completed1
DB06634Casopitant2Completed1
DB00515Cisplatin2Terminated1
DB01234Dexamethasone2Completed2
DB01234Dexamethasone2Terminated1
DB00757Dolasetron2Completed1
DB00544Fluorouracil2Completed1
DB06717Fosaprepitant2Completed1
DB06717Fosaprepitant2Terminated1
DB00889Granisetron2Completed1
DB00762Irinotecan2Completed1
DB00650Leucovorin2Completed1
DB11596Levoleucovorin2Completed1
DB00104Octreotide2Completed1
DB00904Ondansetron2Completed3
DB00526Oxaliplatin2Completed1
DB00377Palonosetron2Completed1
DB00377Palonosetron2Terminated2
DB00433Prochlorperazine2Completed1
DB11699Tropisetron2Completed1
DB00673Aprepitant3Active Not Recruiting1
DB06634Casopitant3Completed1
DB06634Casopitant3Withdrawn1
DB00515Cisplatin3Active Not Recruiting1
DB00531Cyclophosphamide3Active Not Recruiting1
DB01234Dexamethasone3Active Not Recruiting1
DB01234Dexamethasone3Completed4
DB01234Dexamethasone3Withdrawn1
DB14649Dexamethasone acetate3Completed1
DB01248Docetaxel3Completed1
DB00757Dolasetron3Completed1
DB01184Domperidone3Recruiting1
DB00997Doxorubicin3Active Not Recruiting1
DB06717Fosaprepitant3Active Not Recruiting1
DB00996Gabapentin3Completed1
DB00889Granisetron3Active Not Recruiting1
DB00889Granisetron3Completed3
DB00889Granisetron3Unknown Status1
DB12964Lerisetron3Unknown Status1
DB01233Metoclopramide3Completed1
DB00334Olanzapine3Active Not Recruiting1
DB00904Ondansetron3Active Not Recruiting1
DB00904Ondansetron3Completed3
DB00904Ondansetron3Withdrawn1
DB00377Palonosetron3Active Not Recruiting1
DB00377Palonosetron3Completed1
DB00433Prochlorperazine3Completed1
DB01234Dexamethasone4Completed1
DB00486Nabilone4Terminated1
DB00818Propofol4Completed1
DB00673AprepitantNot AvailableCompleted1
DB00673AprepitantNot AvailableTerminated2
DB00673AprepitantNot AvailableWithdrawn1
DB06698BetahistineNot AvailableCompleted1
DB00958CarboplatinNot AvailableTerminated1
DB14547Chloride ionNot AvailableTerminated1
DB00515CisplatinNot AvailableTerminated1
DB00531CyclophosphamideNot AvailableCompleted2
DB01234DexamethasoneNot AvailableCompleted3
DB01234DexamethasoneNot AvailableTerminated2
DB14649Dexamethasone acetateNot AvailableCompleted1
DB00757DolasetronNot AvailableTerminated1
DB00997DoxorubicinNot AvailableCompleted1
DB00889GranisetronNot AvailableCompleted2
DB00889GranisetronNot AvailableTerminated1
DB00904OndansetronNot AvailableCompleted3
DB00904OndansetronNot AvailableUnknown Status1
DB00904OndansetronNot AvailableWithdrawn1
DB00377PalonosetronNot AvailableCompleted1
DB12257PlatinumNot AvailableTerminated1
DB09290RamosetronNot AvailableUnknown Status1