| DB00162 | Vitamin A | For the treatment of vitamin A deficiency. |
| DB00170 | Menadione | The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. |
| DB00459 | Acitretin | For the treatment of severe psoriasis in adults. |
| DB00470 | Dronabinol | For the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments |
| DB00486 | Nabilone | Nabilone is indicated for the treatment of the nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments. This restriction is required because a substantial proportion of any group of patients treated with Nabilone can be expected to experience disturbing psychotomimetic reactions not observed with other antiemetic agents. |
| DB00523 | Alitretinoin | For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. |
| DB00640 | Adenosine | Used as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT. |
| DB00657 | Mecamylamine | For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension |
| DB00755 | Tretinoin | For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage. |
| DB00926 | Etretinate | For the treatment of severe psoriasis in adults. |
| DB00982 | Isotretinoin | Isotretinoin is indicated to treat severe recalcitrant nodular acne and patients ≥12 years enrolled in the iPLEDGE program.[Label,L6579] |
| DB01022 | Phylloquinone | For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia. |
| DB01229 | Paclitaxel | Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer. |
| DB01248 | Docetaxel | For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. It is also used in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer. Furthermore, docetaxel has uses in the treatment of gastric adenocarinoma and head and neck cancer. |
| DB01463 | Fencamfamin | For the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy. |
| DB01744 | Camphor | Not Available |
| DB01785 | Dimethylallyl Diphosphate | Not Available |
| DB02329 | Carbenoxolone | Not Available |
| DB02426 | Carboxyatractyloside | Not Available |
| DB02509 | Farnesol | Not Available |
| DB02513 | Thymol | Not Available |
| DB02552 | Geranyl Diphosphate | Not Available |
| DB02587 | Colforsin | Not Available |
| DB02640 | Fumagillin | Not Available |
| DB02699 | 4-Oxoretinol | Not Available |
| DB02851 | Thiocamphor | Not Available |
| DB02877 | Arotinoid acid | Not Available |
| DB03001 | Peridinin | Not Available |
| DB03460 | Violaxanthin | Not Available |
| DB03540 | Norcamphor | Not Available |
| DB03696 | Lanosterol | Not Available |
| DB03852 | Eucalyptol | Not Available |
| DB04324 | Ovalicin | Not Available |
| DB04501 | Camphane | Not Available |
| DB04695 | Farnesyl thiopyrophosphate | Not Available |
| DB04714 | ISOPENTENYL PYROPHOSPHATE | Not Available |
| DB04864 | Huperzine A | Investigated for use/treatment in alzheimer's disease. |
| DB04930 | Permethrin | For the treatment of infestation with Sarcoptes scabiei (scabies). |
| DB05013 | Ingenol mebutate | For the topical treatment of actinic keratosis. |
| DB05048 | Cannabinor | Investigated for use/treatment in pain (acute or chronic). |
| DB05076 | Fenretinide | Investigated for use/treatment in macular degeneration. |
| DB05265 | Ecabet | For the treatment of reflux oesophagitis and peptic ulcer disease. |
| DB05297 | Paclitaxel docosahexaenoic acid | Investigated for use/treatment in breast cancer, colorectal cancer, gastric cancer, kidney cancer, lung cancer, pancreatic cancer, prostate cancer, and skin cancer. |
| DB05653 | IRX-5183 | Investigated for use/treatment in adverse effects (chemotherapy) and blood (blood forming organ disorders, unspecified). |
| DB05767 | Andrographolide | Investigated for use/treatment in ulcerative colitis. |
| DB05786 | Irofulven | Investigated for use/treatment in brain cancer, breast cancer, endometrial cancer, liver cancer, lung cancer, ovarian cancer, pancreatic cancer, pediatric indications, prostate cancer, and sarcoma. |
| DB05842 | AI-850 | Investigated for use/treatment in breast cancer and solid tumors. |
| DB05974 | Transcrocetinate | Investigated for use/treatment in cancer/tumors (unspecified), hemorrhage, hypoxia, respiratory failure, and strokes. |
| DB05983 | Bardoxolone methyl | Investigated for use/treatment in lymphoma (unspecified), multiple myeloma, and solid tumors. |
| DB06171 | Paclitaxel trevatide | Investigated for use/treatment in brain cancer. |
| DB06347 | Cenisertib | Investigated for use/treatment in solid tumors, leukemia (myeloid), myelodysplastic syndrome, and cancer/tumors (unspecified). |
| DB06444 | Dexanabinol | Investigated for use/treatment in traumatic brain injuries and neurologic disorders. |
| DB06512 | Deramciclane | Investigated for use/treatment in anxiety disorders. |
| DB06515 | Resiniferatoxin | Investigated for use/treatment in interstitial cystitis and urinary incontinence. |
| DB06543 | Astaxanthin | Investigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma. |
| DB06581 | Bevirimat | Investigated for use/treatment in HIV infection. |
| DB06697 | Artemether | Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg. |
| DB06743 | Ginkgolide A | Not Available |
| DB06745 | ginkgolide-C | Not Available |
| DB06746 | ginkgolide-J | Not Available |
| DB06748 | Ginsenoside C | Not Available |
| DB06749 | Ginsenoside Rb1 | Not Available |
| DB06750 | Ginsenoside Rg1 | Not Available |
| DB06755 | Beta carotene | Beta-carotene is FDA approved to be used as a nutrient supplement and to be even added in infant formula as a source of vitamin A.[L2191] It is also approved to be used as a color additive for food products,[L2192] drugs (with the label of "only as a color additive")[L2193] and cosmetics.[L2194]
It is used commonly for the reduction of photosensitivity in patients with erythropoietic protoporphyria and other photosensitivity diseases.[A32485] |
| DB06772 | Cabazitaxel | For treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen. |
| DB07031 | 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid | Not Available |
| DB07780 | Farnesyl diphosphate | Not Available |
| DB07814 | Gibberellic acid | Not Available |
| DB07815 | GIBBERELLIN A4 | Not Available |
| DB07841 | Geranylgeranyl diphosphate | Not Available |
| DB07895 | ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID | Not Available |
| DB08455 | Ro 12-7310 | Not Available |
| DB09052 | Blinatumomab | Indicated for the treatment of Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). |
| DB09061 | Cannabidiol | When used in combination with delta-9-tetrahydrocannabinol as the product Sativex, cannabidiol was given a standard marketing authorization (ie. a Notice of Compliance (NOC)) by Health Canada for the following indications:
1) as adjunctive treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis (MS) who have not responded adequately to other therapy and who demonstrate meaningful improvement during an initial trial of therapy [L886];
Due to the need for confirmatory studies to verify the clinical benefit coupled with the promising nature of the clinical evidence, Sativex was also given a Notice of Compliance with Conditions (NOC/c) by Health Canada for the following indications:
1) as adjunctive treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis;
2) as adjunctive analgesic treatment in adult patients with advanced cancer who experience moderate to severe pain during the highest tolerated dose of strong opioid therapy for persistent background pain [L886]. |
| DB09274 | Artesunate | For the treatment of severe malaria caused by *Plasmodium falciparum* in adults and children [L891] |
| DB09401 | Isosorbide | Indicated for the prevention and treatment of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.[label] |
| DB09534 | Ecamsule | Applied topically to filter out UVA rays. |
| DB11087 | Pyrethrum extract | Not Available |
| DB11176 | Zeaxanthin | Not Available |
| DB11219 | Enzacamene | Indicated for use as an active sunscreen agent. |
| DB11231 | Lycopene | Not Available |
| DB11288 | Borneol | Not Available |
| DB11420 | Squalane | Not Available |
| DB11460 | Squalene | Not Available |
| DB11468 | Tiamulin | Not Available |
| DB11638 | Artenimol | For the treatment of uncomplicated *Plasmodium falciparum* infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with [DB13941]. |
| DB11669 | Ortataxel | Not Available |
| DB11874 | Crocin | Not Available |
| DB12019 | Tesetaxel | Not Available |
| DB12025 | Triptolide | Not Available |
| DB12079 | Gefarnate | Not Available |
| DB12112 | Zuretinol acetate | Not Available |
| DB12148 | Menatetrenone | Not Available |
| DB12193 | Ajulemic acid | Not Available |
| DB12327 | Salvinorin A | Not Available |
| DB12334 | Milataxel | Not Available |
| DB12420 | Diazepinomicin | Not Available |
| DB12430 | BC-3781 | Not Available |
| DB12434 | Steviolbioside | Not Available |
| DB12471 | MK-3118 | Not Available |
| DB12513 | Omaveloxolone | Not Available |
| DB12619 | BMS-188797 | Not Available |
| DB12622 | Lupeol | Not Available |
| DB12633 | BMS-184476 | Not Available |
| DB12671 | Beloranib | Not Available |
| DB12681 | Salirasib | Not Available |
| DB12984 | Larotaxel | Not Available |
| DB13044 | Gossypol | Not Available |
| DB13063 | Parthenolide | Not Available |
| DB13075 | Menaquinone 7 | Not Available |
| DB13089 | Enoxolone | Not Available |
| DB13132 | Artemisinin | Not Available |
| DB13153 | Levomenol | Levomenol has been known to elicit a number of potentially beneficial pharmacological effects, including anti-irritant, anti-inflammatory, and anti-microbial actions. Bisabolol is also demonstrated to enhance the percutaneous absorption of certain molecules |
| DB13163 | Terpin hydrate | Terpin hydrate is used in the treatment of acute and chronic bronchitis, pneumonia, bronchiectasis, chronic obstructive pulmonary disease, infectious and inflammatory diseases of the upper respiratory tract. |
| DB13329 | Guaiazulen | Not Available |
| DB13368 | Motretinide | Not Available |
| DB13600 | Deltamethrin | Not Available |
| DB13640 | Acetoxolone | Not Available |
| DB13714 | Xibornol | Not Available |
| DB13717 | Phenothrin | Not Available |
| DB13721 | Cypermethrin | Not Available |
| DB13746 | Bioallethrin | Bioallethrin was used for lice and scabies infestation. Other pyrethroids are now used in place of bioallethrin. |
| DB13751 | Glycyrrhizic acid | Glycyrrhizic acid is widely applied in foods as a natural sweetener. As a therapeutic agent, is has been used in a vast variety of formulations as it is reported to be anti-inflammatory, anti-ulcer, anti-allergic, antioxidant, anti-tumor, anti-diabetic and hepatoprotective. Due to this properties, its indications have been: treatment of premenstrual syndrome, treatment of viral infections, anti-lipidemic and antihyperglycemic.[A33063] It is also known to be used as a remedy for peptic ulcer and other stomach diseases.[T205] |
| DB13752 | Tetramethrin | Not Available |
| DB13809 | Paclitaxel poliglumex | Not Available |
| DB13828 | Cyfluthrin | Not Available |
| DB13851 | Artemotil | Not Available |
| DB14011 | Nabiximols | In Canada, Sativex has received a Notice of Compliance (NOC) for use as an as adjunctive treatment for symptomatic relief of spasticity in patients with multiple sclerosis (MS) who have not responded adequately to other therapy and who demonstrate meaningful improvement during an initial trial of therapy.
Sativex has also received a Notice of Compliance with Conditions (NOC/c) for use as an adjunctive treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis (MS) and as adjunctive analgesic treatment in adult patients with advanced cancer who experience moderate to severe pain during the highest tolerated dose of strong opioid therapy for persistent background pain.
Marketing authorisations with conditions reflect the promising nature of the clinical evidence and the need for confirmatory studies to verify the clinical benefit. Patients should be advised of the conditional nature of the authorizations with conditions. |
| DB14037 | Madecassic acid | Not Available |
| DB14050 | Cannabidivarin | Cannabidivarin does not currently have any FDA or Health Canada approved indications, however in October 2017 CBDV was given orphan designation by the European Medicines Agency for use in Rett Syndrome [L2952] and again in February 2018 for treatment of Fragile X Syndrome [L2951]. |
| DB14054 | Asiatic acid | Not Available |
| DB14081 | Asiaticoside | Not Available |
| DB14097 | 13-cis-12-(3'-Carboxyphenyl)retinoic acid | Not Available |
| DB14152 | Ginsenosides | Not Available |
| DB14256 | Centella asiatica | Not Available |
| DB14650 | Menadiol diphosphate | Not Available |
| DB14665 | Bornyl acetate | Not Available |
| DB00137 | Lutein | Xanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance. |
| DB08633 | TNP-470 | Not Available |
| DB12480 | Betulinic Acid | Not Available |
| DB14734 | Cannabigerol | Not Available |
| DB14735 | Cannabichromene | Not Available |
| DB14736 | Cannabivarin | Not Available |
| DB14737 | Cannabinol | Not Available |
| DB14815 | Ginsenoside B2 | Not Available |
| DB14936 | Menaquinone 6 | Not Available |
| DB15056 | Bifenthrin | Not Available |
| DB15136 | Rebaudioside A | Not Available |
| DB15201 | Norbixin | Not Available |
| DB15289 | Perilla alcohol | Not Available |
| DB15381 | Menaquinone | Not Available |
| DB15384 | Simotaxel | Not Available |
| DB15462 | Fucoxanthin | Not Available |