Major depressive disorder, recurrent episode

Also known as: Treatment-resistant Depression / Depression NOS / Major depressive illness / Major depression / Major depressive disorder NOS / Depressive Disorder, Major / Major depressive disorder, recurrent episode, unspecified degree

DrugDrug NameDrug Description
DB00334OlanzapineOlanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent.[A176996] The second-generation antipsychotics were introduced in the 90s and quickly widespread due to the presumed higher efficacy, less extrapyramidal side effects and fewer drug-drug interactions.[A177011] Olanzapine presents a very close resemblance to [clozapine] and it only differs by two additional methyl groups and the absence of a chloride moiety.[T554] It was obtained by the research of Eli Lilly and approved to be marketed in the US in 1996.[T548]
DrugDrug NameTargetType
DB00334OlanzapineD(1A) dopamine receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M1target
DB00334OlanzapineMuscarinic acetylcholine receptor M3target
DB00334Olanzapine5-hydroxytryptamine receptor 2Atarget
DB00334OlanzapineD(4) dopamine receptortarget
DB00334OlanzapineHistamine H1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M4target
DB00334OlanzapineMuscarinic acetylcholine receptor M2target
DB00334OlanzapineD(2) dopamine receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 2Ctarget
DB00334OlanzapineD(3) dopamine receptortarget
DB00334OlanzapineAlpha-1B adrenergic receptortarget
DB00334OlanzapineCytochrome P450 1A2enzyme
DB00334Olanzapine5-hydroxytryptamine receptor 3Atarget
DB00334Olanzapine5-hydroxytryptamine receptor 6target
DB00334OlanzapineAlpha-1A adrenergic receptortarget
DB00334OlanzapineD(1B) dopamine receptortarget
DB00334OlanzapineSerum albumincarrier
DB00334OlanzapineAlpha-1-acid glycoprotein 1carrier
DB00334OlanzapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00334OlanzapineCytochrome P450 2D6enzyme
DB00334OlanzapineMultidrug resistance protein 1transporter
DB00334OlanzapineCytochrome P450 2C19enzyme
DB00334OlanzapineCytochrome P450 3A4enzyme
DB00334OlanzapineD(1) dopamine receptortarget
DB00334OlanzapineBeta adrenergic receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 1target
DB00334OlanzapineGABA-A receptor (benzodiazepine site)target
DB00334OlanzapineCytochrome P450 2C9enzyme
DB00334OlanzapineUDP-glucuronosyltransferase 1-4enzyme
DrugDrug NamePhaseStatusCount
DB01221Ketamine2Active Not Recruiting1
DB01221Ketamine2Recruiting1
DB00683Midazolam2Active Not Recruiting1
DB01221Ketamine2 / 3Completed1
DB00683Midazolam2 / 3Completed1
DB00476Duloxetine3Completed5
DB01175Escitalopram3Completed5
DB11823Esketamine3Completed5
DB01104Sertraline3Completed5