Dermatitis, Eczematous

Also known as: Eczema / Eczema NOS / Eczematous rash / Dermatitis eczematoid / Eczematous dermatitis

DrugDrug NameDrug Description
DB13906Aloe Vera LeafAloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern peninsula and various islands. Aloe vera, or _Aloe barbadensis miller_, is the most common species of Aloe that is cultivated for agricultural and medical purposes. It is a perennial succulent xerophyte with elongated leaves that contain a clear gel. While aloe vera has a long history of commercial uses, it is still widely used in cosmetic, food and pharmaceutical products. The use of aloe vera in constipation, inflammatory disorders, cancer, ulcer, and diabetes has also been investigated [A32476]. The active constituents of aloe vera include polysaccharides with protective effects on skin, as they exhibit antioxidant and anti-inflammatory properties [A32481]. Common active polysaccharides include glucomannans, polymannose, and acemannan, or b-(1–4)-acetylated polymannose [A32475]. Acemannan and other modified polysaccharides are responsible in preventing suppression of contact hypersensitivity or immune suppression induced by external factors such as irradiation [A32473].
DB13158ClobetasoneClobetasone is a corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions. Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis.
DB14539Hydrocortisone acetateNot Available
DB14543Hydrocortisone probutateNot Available
DB13964Peanut oilPeanut oil is derived from _Arachis hypogaea_ which can be found in South America, Mexico, and Centro America. The kernels are consumed roasted but a large percentage is used for the production of vegetable oil. The peanut oil represents about 45-52% of the kernel content and it is mainly formed from monounsaturated fat from which the major component is [DB04224].[A33169] Under the FDA, peanut oil is categorized as an approved inactive ingredient for its use in drug products.[L2242] Under Health Canada, it is approved as an active ingredient in over-the-counter combination products.[L1113]
DrugDrug NameTargetType
DB13906Aloe Vera LeafFree radicalstarget
DB13158ClobetasoneGlucocorticoid receptortarget
DB13158ClobetasoneCytochrome P450 3A4enzyme
DB14539Hydrocortisone acetateAnnexin A1target
DB14539Hydrocortisone acetateGlucocorticoid receptortarget
DB14539Hydrocortisone acetateSex hormone-binding globulincarrier
DB14539Hydrocortisone acetateCytochrome P450 3A4enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A5enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A7enzyme
DB14539Hydrocortisone acetateMultidrug resistance protein 1transporter
DB14539Hydrocortisone acetateSolute carrier organic anion transporter family member 1A2transporter
DB14539Hydrocortisone acetateATP-binding cassette sub-family G member 2transporter
DB14539Hydrocortisone acetateCytochrome P450 11B1, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 11B2, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 2C8enzyme
DB14539Hydrocortisone acetateCorticosteroid-binding globulincarrier
DB14539Hydrocortisone acetateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14539Hydrocortisone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14539Hydrocortisone acetateSolute carrier family 22 member 8transporter
DB14543Hydrocortisone probutateAnnexin A1target
DB14543Hydrocortisone probutateGlucocorticoid receptortarget
DB14543Hydrocortisone probutateSex hormone-binding globulincarrier
DB14543Hydrocortisone probutateCytochrome P450 3A4enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A5enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A7enzyme
DB14543Hydrocortisone probutateMultidrug resistance protein 1transporter
DB14543Hydrocortisone probutateSolute carrier organic anion transporter family member 1A2transporter
DB14543Hydrocortisone probutateATP-binding cassette sub-family G member 2transporter
DB14543Hydrocortisone probutateCytochrome P450 11B1, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 11B2, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 2C8enzyme
DB14543Hydrocortisone probutateCorticosteroid-binding globulincarrier
DB14543Hydrocortisone probutateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14543Hydrocortisone probutate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14543Hydrocortisone probutateSolute carrier family 22 member 8transporter
DrugDrug NamePhaseStatusCount
DB00026Anakinra1Terminated1
DB00588Fluticasone propionate1 / 2Not Yet Recruiting1
DB00240Alclometasone2Completed1
DB05676Apremilast2Recruiting1
DB12023Benralizumab2Recruiting1
DB11326Boric acid2Not Yet Recruiting1
DB12041Mapracorat2Completed3
DB01130Prednicarbate2Completed1
DB12580Tradipitant2Completed1
DB14973Abrocitinib3Recruiting2
DB00523Alitretinoin3Completed2
DB12768BCG vaccine3Active Not Recruiting1
DB00443Betamethasone3Completed1
DB00341Cetirizine3Completed1
DB13158Clobetasone3Completed1
DB11286Colloidal oatmeal3Completed1
DB00967Desloratadine3Completed1
DB01260Desonide3Unknown Status1
DB12159Dupilumab3Recruiting1
DB00798Gentamicin3Completed1
DB06282Levocetirizine3Completed1
DB00525Tolnaftate3Completed1
DB05219Crisaborole4Recruiting1
DB01260Desonide4Completed1
DB12159Dupilumab4Recruiting1
DB11058Petrolatum4Recruiting1
DB09495AvobenzoneNot AvailableUnknown Status1
DB00091CiclosporinNot AvailableCompleted1
DB09535OctocryleneNot AvailableUnknown Status1
DB14329Sunflower oilNot AvailableUnknown Status1
DB00620TriamcinoloneNot AvailableTerminated1
DB08604TriclosanNot AvailableUnknown Status1