Octisalate

Identification

Name
Octisalate
Accession Number
DB11062
Type
Small Molecule
Groups
Approved
Description

Also known as Ethylhexyl Salicylate. Octyl salicylate is an oil soluble chemical sunscreen agent that absorbs UVB radiation. It does not protect against UVA. Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other UV filters. Octyl salicylate appears to have a good safety profile. It covers wavelength in the range 295-315 nm, peak at 307-310 nm.

It is an ester of salicylic acid and 2-ethylhexanol. The salicylate portion of the molecule absorbs ultraviolet light, protecting skin from the harmful effects of exposure to sunlight. The ethylhexanol portion is a fatty alcohol, adding emollient and oil-like (water resistant) properties

Synonyms
Not Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Balancing Dynamics Kit JafraKitJafra Cosmetics2012-11-16Not applicableUs
Octisalate, Avobenzone, Homosalate, Octocrylene SPF30KitTopicalJulep Nail Parlor2013-09-10Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
01 Balancing Foundation SPF 15Octisalate (2.5 mg/.5mL) + Octinoxate (3.75 mg/.5mL) + Titanium dioxide (1.45 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-17Us
02 Balancing Foundation SPF 15Octisalate (2.5 mg/.5mL) + Octinoxate (3.75 mg/.5mL) + Titanium dioxide (1.45 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-17Us
03 Balancing Foundation SPF 15Octisalate (2.5 mg/.5mL) + Octinoxate (3.75 mg/.5mL) + Titanium dioxide (1.45 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-17Us
04 Balancing Foundation SPF 15Octisalate (2.5 mg/.5mL) + Octinoxate (3.75 mg/.5mL) + Titanium dioxide (1.45 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-17Us
05 Balancing Foundation SPF 15Octisalate (2.5 mg/.5mL) + Octinoxate (3.75 mg/.5mL) + Titanium dioxide (1.45 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-17Us
06 Balancing Foundation SPF 15Octisalate (2.5 mg/.5mL) + Octinoxate (3.75 mg/.5mL) + Titanium dioxide (1.45 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-17Us
07 Balancing Foundation SPF 15Octisalate (2.5 mg/.5mL) + Octinoxate (3.75 mg/.5mL) + Titanium dioxide (1.45 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-17Us
08 Balancing Foundation SPF 15Octisalate (2.5 mg/.5mL) + Octinoxate (3.75 mg/.5mL) + Titanium dioxide (1.45 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-17Us
09 Balancing Foundation SPF 15Octisalate (2.5 mg/.5mL) + Octinoxate (3.75 mg/.5mL) + Titanium dioxide (1.45 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-17Us
10 Balancing Foundation SPF 15Octisalate (2.5 mg/.5mL) + Octinoxate (3.75 mg/.5mL) + Titanium dioxide (1.45 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-17Us
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
BEYOND THE SHAVE For MenOctisalate + Allantoin + Avobenzone + Dimethicone + Homosalate + Octocrylene + SulfurKitTopicalRodan & Fields2017-06-01Not applicableUs
D-one By Tamdoan Bb LightOctisalate (5 g/100g) + Adenosine (.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (1 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2016-02-232017-11-30Us
D-one By Tamdoan Bb MediumOctisalate (5 g/100g) + Adenosine (.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (1 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2016-02-23Not applicableUs
D-one By Tamdoan Sunscreen 50Octisalate (5 g/100g) + Adenosine (.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (1 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2016-02-23Not applicableUs
Dr.althea Aurora Cover Cushion 21Octisalate (4.8 g/100g) + Adenosine (.04 g/100g) + Nicotinamide (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (2 g/100g) + Titanium dioxide (9.00552 g/100g) + Zinc oxide (2 g/100g)LiquidTopicalDr. Althea2017-04-03Not applicableUs
Propolis 20 BB CreamOctisalate (2 g/100g) + Adenosine (.04 g/100g) + Arbutin (2 g/100g) + Octinoxate (5 g/100g) + Titanium dioxide (9.34 g/100g)CreamTopicalAmi Cosmetic Co.,Ltd.2016-02-23Not applicableUs
Propolis 27 Cover CushionOctisalate (4.8 g/100g) + Adenosine (.00385 g/100g) + Nicotinamide (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (2 g/100g) + Titanium dioxide (13.9936 g/100g) + Zinc oxide (2 g/100g)LiquidTopicalAmi Cosmetic Co.,Ltd.2015-07-05Not applicableUs
REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel SizeOctisalate + Avobenzone + Homosalate + Hydroquinone + OctocryleneKitTopicalRodan & Fields2017-07-24Not applicableUs
REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age SpotsOctisalate + Avobenzone + Homosalate + Hydroquinone + OctocryleneKitTopicalRodan & Fields2017-06-01Not applicableUs
Secret Key Natural Cc Cushion Spf50 Plus / 01 Light CcOctisalate (3 g/100g) + Enzacamene (3 g/100g) + Octinoxate (7 g/100g) + Titanium dioxide (12 g/100g)LiquidTopicalZenpia2015-07-05Not applicableUs
Categories
UNII
4X49Y0596W
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.

Associated Conditions
Pharmacodynamics

Data not found.

Mechanism of action

Chemical sunscreen, it acts through absorption of UVB light and not UVA.

Absorption

Intended for local use only, no systemic absorption.

Volume of distribution

Intended for local use only, no systemic absorption.

Protein binding

Intended for local use only, no systemic absorption.

Metabolism

Intended for local use only, no systemic absorption.

Route of elimination

Intended for local use only, no systemic absorption.

Half life

Intended for local use only, no systemic absorption.

Clearance

Intended for local use only, no systemic absorption.

Toxicity

LD50, (oral, rat): > 5000 mg/Kg. LD50 (dermal, rabbit): > 5000 mg/Kg.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. product info [Link]
  2. wikipedia [Link]
  3. MSDS [Link]
External Links
PubChem Substance
347911101
Wikipedia
Octisalate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedOtherMelasma1
2CompletedSupportive CareAdvanced Malignant Neoplasm / Dermatologic Complication / Dermatologic Complications / Neoplasms, Malignant1
3CompletedSupportive CareDermatologic Complications / Unspecified Adult Solid Tumor, Protocol Specific1
4TerminatedNot AvailableSkin Aging1
Not AvailableCompletedPreventionPigmentation From Visible Light1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GelCutaneous
CreamTopical
LotionTopical
Kit
SalveTopical
Liquid; sprayTopical
Kit
Cream, augmentedTopical
Cloth; creamTopical
LiquidTopical
SprayTopical
Gel; kit; lotionTopical
OilTopical
Aerosol, foamTopical
Liquid; lotionTopical
Kit; stickTopical
KitTopical
Lotion / shampooTopical
PasteTopical
JellyTopical
GelTopical
SolutionTopical
LipstickTopical
CreamCutaneous
PowderTopical
TabletOral
Aerosol, sprayTopical
KitTopical
LotionCutaneous
Cream; kitTopical
ClothTopical
StickTopical
EmulsionTopical
AerosolTopical
OintmentTopical
Spray, suspensionTopical
SprayOral
SuspensionTopical
Lotion; sprayTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on June 02, 2018 08:22