Octisalate

Identification

Name
Octisalate
Accession Number
DB11062
Type
Small Molecule
Groups
Approved, Investigational
Description

Also known as Ethylhexyl Salicylate. Octyl salicylate is an oil soluble chemical sunscreen agent that absorbs UVB radiation. It does not protect against UVA. Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other UV filters. Octyl salicylate appears to have a good safety profile. It covers wavelength in the range 295-315 nm, peak at 307-310 nm.

It is an ester of salicylic acid and 2-ethylhexanol. The salicylate portion of the molecule absorbs ultraviolet light, protecting skin from the harmful effects of exposure to sunlight. The ethylhexanol portion is a fatty alcohol, adding emollient and oil-like (water resistant) properties

Synonyms
Not Available
Active Moieties
NameKindUNIICASInChI Key
Salicylic acidunknownO414PZ4LPZ69-72-7YGSDEFSMJLZEOE-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
01 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
02 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
03 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
04 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
05 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
06 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
07 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
08 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
09 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
10 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05Us
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
BEYOND THE SHAVE For MenOctisalate (5 g/100mL) + Allantoin (0.5 g/100mL) + Avobenzone (3.0 g/100mL) + Dimethicone (2.9 g/100mL) + Homosalate (2.5 g/100mL) + Octasulfur (3.0 g/100mL) + Octocrylene (2.7 g/100mL)KitTopicalRodan & Fields2017-06-01Not applicableUs
D-one By Tamdoan Bb LightOctisalate (5 g/100g) + Adenosine (0.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (1 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2016-02-232016-09-05Us
D-one By Tamdoan Bb MediumOctisalate (5 g/100g) + Adenosine (0.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (1 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2016-02-23Not applicableUs
D-one By Tamdoan Sunscreen 50Octisalate (5 g/100g) + Adenosine (0.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (1 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2016-02-23Not applicableUs
Dr.althea Aurora Cover Cushion 21Octisalate (4.8 g/100g) + Adenosine (0.04 g/100g) + Nicotinamide (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (2 g/100g) + Titanium dioxide (9.00552 g/100g) + Zinc oxide (2 g/100g)LiquidTopicalDr. Althea2017-04-03Not applicableUs
Propolis 20 BB CreamOctisalate (2 g/100g) + Adenosine (0.04 g/100g) + Arbutin (2 g/100g) + Octinoxate (5 g/100g) + Titanium dioxide (9.34 g/100g)CreamTopicalAmi Cosmetic Co.,Ltd.2016-02-23Not applicableUs
Propolis 27 Cover CushionOctisalate (4.8 g/100g) + Adenosine (0.00385 g/100g) + Nicotinamide (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (2 g/100g) + Titanium dioxide (13.9936 g/100g) + Zinc oxide (2 g/100g)LiquidTopicalAmi Cosmetic Co.,Ltd.2015-07-05Not applicableUs
REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel SizeOctisalate (5 g/100mL) + Avobenzone (3.0 g/100mL) + Homosalate (10 g/100mL) + Hydroquinone (2 g/100mL) + Hydroquinone (2 g/100mL) + Octocrylene (2.6 g/100mL)KitTopicalRodan & Fields2017-07-24Not applicableUs
REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age SpotsOctisalate (5 g/100mL) + Avobenzone (3.0 g/100mL) + Homosalate (10 g/100mL) + Hydroquinone (2 g/100mL) + Hydroquinone (2 g/100mL) + Octocrylene (2.6 g/100mL)KitTopicalRodan & Fields2017-06-01Not applicableUs
Secret Key Natural Cc Cushion Spf50 Pa / 02 Natural CcOctisalate (3 g/100g) + Enzacamene (3 g/100g) + Octinoxate (7 g/100g) + Titanium dioxide (12 g/100g)LiquidTopicalZenpia2015-07-052016-08-01Us
Categories
UNII
4X49Y0596W
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.

Associated Conditions
Pharmacodynamics

Data not found.

Mechanism of action

Chemical sunscreen, it acts through absorption of UVB light and not UVA.

Absorption

Intended for local use only, no systemic absorption.

Volume of distribution

Intended for local use only, no systemic absorption.

Protein binding

Intended for local use only, no systemic absorption.

Metabolism

Intended for local use only, no systemic absorption.

Route of elimination

Intended for local use only, no systemic absorption.

Half life

Intended for local use only, no systemic absorption.

Clearance

Intended for local use only, no systemic absorption.

Toxicity

LD50, (oral, rat): > 5000 mg/Kg. LD50 (dermal, rabbit): > 5000 mg/Kg.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. product info [Link]
  2. wikipedia [Link]
  3. MSDS [Link]
External Links
PubChem Substance
347911101
Wikipedia
Octisalate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedOtherMelasma1
1Active Not RecruitingBasic ScienceHealthy Volunteers1
1Not Yet RecruitingOtherHealthy Volunteers1
1Not Yet RecruitingPreventionActinic Keratosis (AK) / Therapy, Photodynamic1
1RecruitingOtherSystemic Exposure to Sunscreen Ingredients1
1RecruitingPreventionBreast Cancer Prevention / Mammographic Density1
2CompletedSupportive CareAdvanced Malignant Neoplasm / Dermatologic Complication / Dermatologic Complications / Neoplasms, Malignant1
2CompletedTreatmentDiabetes, Diabetes Mellitus Type 11
2, 3RecruitingTreatmentProstate Cancer1
3CompletedSupportive CareDermatologic Complications / Unspecified Adult Solid Tumor, Protocol Specific1
3CompletedTreatmentMenstrual Irregularities1
3Not Yet RecruitingTreatmentAnaesthesia therapy / Shock, Septic1
4CompletedTreatmentHypermenorrhea1
4RecruitingDiagnosticCancer, Breast / Sentinel Lymph Node Biopsy1
4RecruitingTreatmentColon Cancer Stage1
4TerminatedNot AvailableSkin Aging1
Not AvailableCompletedNot AvailableDexmedetomidine / Endoscopy, Gastrointestinal / Sedation therapy1
Not AvailableCompletedNot AvailableMidazolam1
Not AvailableCompletedPreventionPigmentation From Visible Light1
Not AvailableNot Yet RecruitingTreatmentIntra-nasal Delevery Device / Procedural Sedation1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GelCutaneous
EmulsionTopical
SalveTopical
LotionTopical20 mg/1mL
Liquid; sprayTopical
OintmentTopical
Cloth; creamTopical
CreamCutaneous
StickTopical
LipstickTopical
Aerosol, foamTopical
Gel; kit; lotionTopical
Liquid; lotionTopical
JellyTopical
Kit; stickTopical
KitTopical
Cream, augmentedTopical
Lotion / shampooTopical
PasteTopical
GelTopical
AerosolTopical
Aerosol, sprayTopical
PowderTopical
LotionCutaneous
CreamTopical
Cream; kitTopical
LiquidTopical
SolutionTopical
Spray, suspensionTopical
SprayOral
Kit
LotionTopical
SprayTopical
SuspensionTopical
OilTopical
LotionOral
Lotion; sprayTopical
ClothTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on September 13, 2018 16:00